TY  - JOUR
AU  - Cavallieri, Francesco
AU  - Sellner, Johann
AU  - Akhvlediani, Tamar
AU  - Bassetti, Claudio L.
AU  - Bereczki, Daniel
AU  - Fanciulli, Alessandra
AU  - Filipović, Saša
AU  - Guekht, Alla
AU  - Helbok, Raimund
AU  - Hochmeister, Sonja
AU  - Martinelli Boneschi, Filippo
AU  - von Oertzen, Tim J.
AU  - Özturk, Serefnur
AU  - Priori, Alberto
AU  - Ramankulov, Dauren
AU  - Willekens, Barbara
AU  - Rakusa, Martin
AU  - Moro, Elena
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1480
AB  - Background:The COVID-19 pandemic has made its mark on world history forever causing millions of deaths, and straining health systems, economies, and societies worldwide. The European Academy of Neurology (EAN) reacted promptly. A special NeuroCOVID-19 Task Force was set up at the beginning of the pandemic to promote knowledge, research, international collaborations, and raise awareness about the prevention and treatment of COVID-19-related neurological issues. Methods Activities carried out during and after the pandemic by the EAN NeuroCOVID-19 Task Force are described. The main aim was to review all these initiatives in detail as an overarching lesson from the past to improve the present and be better prepared in case of future pandemics. Results During the pandemic, the Task Force was engaged in several initiatives: the creation of the EAN NEuro-covid ReGistrY (ENERGY); the launch of several surveys (neurological manifestations of COVID-19 infection; the pandemic's impact on patients with chronic neurological diseases; the pandemic's impact of restrictions for clinical practice, curricular training, and health economics); the publication of position papers regarding the management of patients with neurological diseases during the pandemic, and vaccination hesitancy among people with chronic neurological disorders; and the creation of a dedicated “COVID-19 Breaking News” section in EANpages. Conclusions The EAN NeuroCOVID-19 Task Force was immediately engaged in various activities to participate in the fight against COVID-19. The Task Force's concerted strategy may serve as a foundation for upcoming global neurological emergencies.
PB  - Wiley-Blackwell
T2  - European Journal of Neurology
T1  - The European Academy of Neurology NeuroCOVID-19 Task Force: A lesson for the future
IS  - n/a
SP  - e16321
VL  - n/a
DO  - 10.1111/ene.16321
ER  - 

@article{
author = "Cavallieri, Francesco and Sellner, Johann and Akhvlediani, Tamar and Bassetti, Claudio L. and Bereczki, Daniel and Fanciulli, Alessandra and Filipović, Saša and Guekht, Alla and Helbok, Raimund and Hochmeister, Sonja and Martinelli Boneschi, Filippo and von Oertzen, Tim J. and Özturk, Serefnur and Priori, Alberto and Ramankulov, Dauren and Willekens, Barbara and Rakusa, Martin and Moro, Elena",
abstract = "Background:The COVID-19 pandemic has made its mark on world history forever causing millions of deaths, and straining health systems, economies, and societies worldwide. The European Academy of Neurology (EAN) reacted promptly. A special NeuroCOVID-19 Task Force was set up at the beginning of the pandemic to promote knowledge, research, international collaborations, and raise awareness about the prevention and treatment of COVID-19-related neurological issues. Methods Activities carried out during and after the pandemic by the EAN NeuroCOVID-19 Task Force are described. The main aim was to review all these initiatives in detail as an overarching lesson from the past to improve the present and be better prepared in case of future pandemics. Results During the pandemic, the Task Force was engaged in several initiatives: the creation of the EAN NEuro-covid ReGistrY (ENERGY); the launch of several surveys (neurological manifestations of COVID-19 infection; the pandemic's impact on patients with chronic neurological diseases; the pandemic's impact of restrictions for clinical practice, curricular training, and health economics); the publication of position papers regarding the management of patients with neurological diseases during the pandemic, and vaccination hesitancy among people with chronic neurological disorders; and the creation of a dedicated “COVID-19 Breaking News” section in EANpages. Conclusions The EAN NeuroCOVID-19 Task Force was immediately engaged in various activities to participate in the fight against COVID-19. The Task Force's concerted strategy may serve as a foundation for upcoming global neurological emergencies.",
publisher = "Wiley-Blackwell",
journal = "European Journal of Neurology",
title = "The European Academy of Neurology NeuroCOVID-19 Task Force: A lesson for the future",
number = "n/a",
pages = "e16321",
volume = "n/a",
doi = "10.1111/ene.16321"
}

Cavallieri, F., Sellner, J., Akhvlediani, T., Bassetti, C. L., Bereczki, D., Fanciulli, A., Filipović, S., Guekht, A., Helbok, R., Hochmeister, S., Martinelli Boneschi, F., von Oertzen, T. J., Özturk, S., Priori, A., Ramankulov, D., Willekens, B., Rakusa, M.,& Moro, E..The European Academy of Neurology NeuroCOVID-19 Task Force: A lesson for the future. in European Journal of Neurology
Wiley-Blackwell., n/a(n/a), e16321.
https://doi.org/10.1111/ene.16321

Cavallieri F, Sellner J, Akhvlediani T, Bassetti CL, Bereczki D, Fanciulli A, Filipović S, Guekht A, Helbok R, Hochmeister S, Martinelli Boneschi F, von Oertzen TJ, Özturk S, Priori A, Ramankulov D, Willekens B, Rakusa M, Moro E. The European Academy of Neurology NeuroCOVID-19 Task Force: A lesson for the future. in European Journal of Neurology.n/a(n/a):e16321.
doi:10.1111/ene.16321 .

Cavallieri, Francesco, Sellner, Johann, Akhvlediani, Tamar, Bassetti, Claudio L., Bereczki, Daniel, Fanciulli, Alessandra, Filipović, Saša, Guekht, Alla, Helbok, Raimund, Hochmeister, Sonja, Martinelli Boneschi, Filippo, von Oertzen, Tim J., Özturk, Serefnur, Priori, Alberto, Ramankulov, Dauren, Willekens, Barbara, Rakusa, Martin, Moro, Elena, "The European Academy of Neurology NeuroCOVID-19 Task Force: A lesson for the future" in European Journal of Neurology, n/a, no. n/a:e16321,
https://doi.org/10.1111/ene.16321 . .

TY  - JOUR
AU  - Međaković, Jelena
AU  - Čivljak, Antonia
AU  - Zorčec, Tatjana
AU  - Vučić, Vesna
AU  - Ristić-Medić, Danijela
AU  - Veselinović, Aleksandra
AU  - Čivljak, Marta
AU  - Puljak, Livia
PY  - 2024
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1487
AB  - Background: Parents/caregivers of children with developmental disabilities (CDD) have a wide range of support needs and there are various interventions available. Support, challenges, and needs among parents/caregivers of CDD likely vary in different geographical settings. This study aimed to analyze the perceptions of support, challenges, and needs among parents/caregivers of CDD in Croatia, North Macedonia, and Serbia. Methods: We conducted a cross-sectional study in March-April 2023 within the Erasmus + SynergyEd project. The eligible participants were parents and caregivers of CDD in Croatia, North Macedonia, and Serbia, who filled out a modified Caregiver Needs Survey online. Results: Among 953 participants, 542 (57%) were from Croatia, 205 (21%) were from North Macedonia and 206 (22%) were from Serbia. The most common diagnosis of participants’ children was autism spectrum disorder (26%). The child most often received the first diagnosis at the median of 2 years, diagnosed by a team of professionals. More than half (58%) of children attended preschool and public school, while 22% did not attend any schooling. Additional support from the state/city/county was received by 66% of CDD. Most participants declared not participating in association/organization for family support. Participants mostly (68%) used experts who work with the child as a source of information about their child’s condition, followed by the Internet (53%). In the last 12 months, 60% of participants had difficulties with the availability of services in their area or problems getting appointments. The biggest problem in getting support was ensuring the child’s basic rights were protected. Participants stated that ensuring greater rights for CDD was the greatest need for their families. Conclusion: Parents/caregivers of CDD in Croatia, North Macedonia, and Serbia faced multiple challenges, but most of them were satisfied with the services provided to their children. Future efforts to develop policies and services related to CDD should consider the opinions of their parents/caregivers and disparities in access to services.
PB  - Springer Nature
T2  - BMC Pediatrics
T1  - Perceptions on support, challenges and needs among parents and caregivers of children with developmental disabilities in Croatia, North Macedonia and Serbia: a cross-sectional study
IS  - 1
SP  - 297
VL  - 24
DO  - 10.1186/s12887-024-04770-7
ER  - 

@article{
author = "Međaković, Jelena and Čivljak, Antonia and Zorčec, Tatjana and Vučić, Vesna and Ristić-Medić, Danijela and Veselinović, Aleksandra and Čivljak, Marta and Puljak, Livia",
year = "2024",
abstract = "Background: Parents/caregivers of children with developmental disabilities (CDD) have a wide range of support needs and there are various interventions available. Support, challenges, and needs among parents/caregivers of CDD likely vary in different geographical settings. This study aimed to analyze the perceptions of support, challenges, and needs among parents/caregivers of CDD in Croatia, North Macedonia, and Serbia. Methods: We conducted a cross-sectional study in March-April 2023 within the Erasmus + SynergyEd project. The eligible participants were parents and caregivers of CDD in Croatia, North Macedonia, and Serbia, who filled out a modified Caregiver Needs Survey online. Results: Among 953 participants, 542 (57%) were from Croatia, 205 (21%) were from North Macedonia and 206 (22%) were from Serbia. The most common diagnosis of participants’ children was autism spectrum disorder (26%). The child most often received the first diagnosis at the median of 2 years, diagnosed by a team of professionals. More than half (58%) of children attended preschool and public school, while 22% did not attend any schooling. Additional support from the state/city/county was received by 66% of CDD. Most participants declared not participating in association/organization for family support. Participants mostly (68%) used experts who work with the child as a source of information about their child’s condition, followed by the Internet (53%). In the last 12 months, 60% of participants had difficulties with the availability of services in their area or problems getting appointments. The biggest problem in getting support was ensuring the child’s basic rights were protected. Participants stated that ensuring greater rights for CDD was the greatest need for their families. Conclusion: Parents/caregivers of CDD in Croatia, North Macedonia, and Serbia faced multiple challenges, but most of them were satisfied with the services provided to their children. Future efforts to develop policies and services related to CDD should consider the opinions of their parents/caregivers and disparities in access to services.",
publisher = "Springer Nature",
journal = "BMC Pediatrics",
title = "Perceptions on support, challenges and needs among parents and caregivers of children with developmental disabilities in Croatia, North Macedonia and Serbia: a cross-sectional study",
number = "1",
pages = "297",
volume = "24",
doi = "10.1186/s12887-024-04770-7"
}

Međaković, J., Čivljak, A., Zorčec, T., Vučić, V., Ristić-Medić, D., Veselinović, A., Čivljak, M.,& Puljak, L.. (2024). Perceptions on support, challenges and needs among parents and caregivers of children with developmental disabilities in Croatia, North Macedonia and Serbia: a cross-sectional study. in BMC Pediatrics
Springer Nature., 24(1), 297.
https://doi.org/10.1186/s12887-024-04770-7

Međaković J, Čivljak A, Zorčec T, Vučić V, Ristić-Medić D, Veselinović A, Čivljak M, Puljak L. Perceptions on support, challenges and needs among parents and caregivers of children with developmental disabilities in Croatia, North Macedonia and Serbia: a cross-sectional study. in BMC Pediatrics. 2024;24(1):297.
doi:10.1186/s12887-024-04770-7 .

Međaković, Jelena, Čivljak, Antonia, Zorčec, Tatjana, Vučić, Vesna, Ristić-Medić, Danijela, Veselinović, Aleksandra, Čivljak, Marta, Puljak, Livia, "Perceptions on support, challenges and needs among parents and caregivers of children with developmental disabilities in Croatia, North Macedonia and Serbia: a cross-sectional study" in BMC Pediatrics, 24, no. 1 (2024):297,
https://doi.org/10.1186/s12887-024-04770-7 . .

TY  - JOUR
AU  - Li, Yong
AU  - Cheng, Rong
AU  - Liu, Xiao-Yu
AU  - Mihaljica, Darko
AU  - Cheng, Tian-Yin
PY  - 2024
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1486
AB  - The majority of ixodid ticks display host-specificity to varying extents. Feeding on different hosts affects their development and reproduction. Consequences can be analyzed at the level of the egg, as it is the initial stage of tick development. Tick egg proteins are abundant and diverse, providing nutrients for embryonic development. However, studies on tick egg profiles are scarce. In this study, we aimed to analyze whether feeding Haemaphysalis qinghaiensis ticks on the yaks (Bos grunniens) and domestic sheep (Ovis aries) has an impact on the variety and variability of the egg proteome. Detached engorged females were used to lay eggs, which were then collected, dewaxed, and subjected to protein extraction. The extracted egg proteins were enzymatically digested using Filter-Aided Sample Preparation (FASP), and the unique peptides were separated and detected by Liquid Chromatography-tandem Mass Spectrometry (LC–MS/MS). The MS data were searched against the previously constructed whole tick transcriptome library of H. qinghaiensis, and the UniProt database for the identification of tick-derived egg proteins. The analysis revealed 49 and 53 high-confidence proteins identified in eggs collected from B. grunniens (EggBg) and O. aries (EggOa), respectively. Of these, 46 high-confidence proteins were common to both egg types, while three were unique to EggBg and seven to EggOa. All the identified proteins mainly belonged to enzymes, enzyme inhibitors, transporters, and proteins with unknown functions. The differential abundance analysis showed that nine proteins were significantly more present in EggBg, while six were significantly more present in EggOa. Overall, enzymes were the most diverse group, while vitellogenin (Vg) was the most abundant. Blood meal uptake on different hosts has a certain effect on the egg proteome composition and the abundance of some proteins, but it may also lead to compensation of protein roles.
PB  - Springer  Nature
T2  - Parasitology Research
T2  - Parasitology Research
T1  - The effect of feeding on different hosts on the egg proteins in Haemaphysalis qinghaiensis tick
IS  - 4
SP  - 197
VL  - 123
DO  - 10.1007/s00436-024-08211-3
ER  - 

@article{
author = "Li, Yong and Cheng, Rong and Liu, Xiao-Yu and Mihaljica, Darko and Cheng, Tian-Yin",
year = "2024",
abstract = "The majority of ixodid ticks display host-specificity to varying extents. Feeding on different hosts affects their development and reproduction. Consequences can be analyzed at the level of the egg, as it is the initial stage of tick development. Tick egg proteins are abundant and diverse, providing nutrients for embryonic development. However, studies on tick egg profiles are scarce. In this study, we aimed to analyze whether feeding Haemaphysalis qinghaiensis ticks on the yaks (Bos grunniens) and domestic sheep (Ovis aries) has an impact on the variety and variability of the egg proteome. Detached engorged females were used to lay eggs, which were then collected, dewaxed, and subjected to protein extraction. The extracted egg proteins were enzymatically digested using Filter-Aided Sample Preparation (FASP), and the unique peptides were separated and detected by Liquid Chromatography-tandem Mass Spectrometry (LC–MS/MS). The MS data were searched against the previously constructed whole tick transcriptome library of H. qinghaiensis, and the UniProt database for the identification of tick-derived egg proteins. The analysis revealed 49 and 53 high-confidence proteins identified in eggs collected from B. grunniens (EggBg) and O. aries (EggOa), respectively. Of these, 46 high-confidence proteins were common to both egg types, while three were unique to EggBg and seven to EggOa. All the identified proteins mainly belonged to enzymes, enzyme inhibitors, transporters, and proteins with unknown functions. The differential abundance analysis showed that nine proteins were significantly more present in EggBg, while six were significantly more present in EggOa. Overall, enzymes were the most diverse group, while vitellogenin (Vg) was the most abundant. Blood meal uptake on different hosts has a certain effect on the egg proteome composition and the abundance of some proteins, but it may also lead to compensation of protein roles.",
publisher = "Springer  Nature",
journal = "Parasitology Research, Parasitology Research",
title = "The effect of feeding on different hosts on the egg proteins in Haemaphysalis qinghaiensis tick",
number = "4",
pages = "197",
volume = "123",
doi = "10.1007/s00436-024-08211-3"
}

Li, Y., Cheng, R., Liu, X., Mihaljica, D.,& Cheng, T.. (2024). The effect of feeding on different hosts on the egg proteins in Haemaphysalis qinghaiensis tick. in Parasitology Research
Springer  Nature., 123(4), 197.
https://doi.org/10.1007/s00436-024-08211-3

Li Y, Cheng R, Liu X, Mihaljica D, Cheng T. The effect of feeding on different hosts on the egg proteins in Haemaphysalis qinghaiensis tick. in Parasitology Research. 2024;123(4):197.
doi:10.1007/s00436-024-08211-3 .

Li, Yong, Cheng, Rong, Liu, Xiao-Yu, Mihaljica, Darko, Cheng, Tian-Yin, "The effect of feeding on different hosts on the egg proteins in Haemaphysalis qinghaiensis tick" in Parasitology Research, 123, no. 4 (2024):197,
https://doi.org/10.1007/s00436-024-08211-3 . .

TY  - JOUR
AU  - Trivanović, Drenka
AU  - Mojsilović, Slavko
AU  - Bogosavljević, Nikola
AU  - Jurišić, Vladimir
AU  - Jauković, Aleksandra
PY  - 2024
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1460
AB  - Among multiple hemostasis components, platelets hyperactivity plays major roles in cancer progression by providing surface and internal components for intercellular crosstalk as well as by behaving like immune cells. Since platelets participate and regulate immunity in homeostatic and disease states, we assumed that revealing platelets profile might help in conceiving novel anti-cancer immune-based strategies. The goal of this review is to compile and discuss the most recent reports on the nature of cancer-associated platelets and their interference with immunotherapy. An increasing number of studies have emphasized active communication between cancer cells and platelets, with platelets promoting cancer cell survival, growth, and metastasis. The anti-cancer potential of platelet-directed therapy has been intensively investigated, and anti-platelet agents may prevent cancer progression and improve the survival of cancer patients. Platelets can (i) reduce antitumor activity; (ii) support immunoregulatory cells and factors generation; (iii) underpin metastasis and, (iv) interfere with immunotherapy by expressing ligands of immune checkpoint receptors. Mediators produced by tumor cell-induced platelet activation support vein thrombosis, constrain anti-tumor T- and natural killer cell response, while contributing to extravasation of tumor cells, metastatic potential, and neovascularization within the tumor. Recent studies showed that attenuation of immunothrombosis, modulation of platelets and their factors have a good perspective in immunotherapy optimization. Particularly, blockade of intra-tumoral platelet-associated programmed death-ligand 1 might promote anti-tumor T cell-induced cytotoxicity. Collectively, these findings suggest that platelets might represent the source of relevant cancer staging biomarkers, as well as promising targets and carriers in immunotherapeutic approaches for combating cancer.
PB  - Neoplasia Press, Inc.
T2  - Translational Oncology
T2  - Translational OncologyTranslational Oncology
T1  - Revealing profile of cancer-educated platelets and their factors to foster immunotherapy development
SP  - 101871
VL  - 40
DO  - 10.1016/j.tranon.2023.101871
ER  - 

@article{
author = "Trivanović, Drenka and Mojsilović, Slavko and Bogosavljević, Nikola and Jurišić, Vladimir and Jauković, Aleksandra",
year = "2024",
abstract = "Among multiple hemostasis components, platelets hyperactivity plays major roles in cancer progression by providing surface and internal components for intercellular crosstalk as well as by behaving like immune cells. Since platelets participate and regulate immunity in homeostatic and disease states, we assumed that revealing platelets profile might help in conceiving novel anti-cancer immune-based strategies. The goal of this review is to compile and discuss the most recent reports on the nature of cancer-associated platelets and their interference with immunotherapy. An increasing number of studies have emphasized active communication between cancer cells and platelets, with platelets promoting cancer cell survival, growth, and metastasis. The anti-cancer potential of platelet-directed therapy has been intensively investigated, and anti-platelet agents may prevent cancer progression and improve the survival of cancer patients. Platelets can (i) reduce antitumor activity; (ii) support immunoregulatory cells and factors generation; (iii) underpin metastasis and, (iv) interfere with immunotherapy by expressing ligands of immune checkpoint receptors. Mediators produced by tumor cell-induced platelet activation support vein thrombosis, constrain anti-tumor T- and natural killer cell response, while contributing to extravasation of tumor cells, metastatic potential, and neovascularization within the tumor. Recent studies showed that attenuation of immunothrombosis, modulation of platelets and their factors have a good perspective in immunotherapy optimization. Particularly, blockade of intra-tumoral platelet-associated programmed death-ligand 1 might promote anti-tumor T cell-induced cytotoxicity. Collectively, these findings suggest that platelets might represent the source of relevant cancer staging biomarkers, as well as promising targets and carriers in immunotherapeutic approaches for combating cancer.",
publisher = "Neoplasia Press, Inc.",
journal = "Translational Oncology, Translational OncologyTranslational Oncology",
title = "Revealing profile of cancer-educated platelets and their factors to foster immunotherapy development",
pages = "101871",
volume = "40",
doi = "10.1016/j.tranon.2023.101871"
}

Trivanović, D., Mojsilović, S., Bogosavljević, N., Jurišić, V.,& Jauković, A.. (2024). Revealing profile of cancer-educated platelets and their factors to foster immunotherapy development. in Translational Oncology
Neoplasia Press, Inc.., 40, 101871.
https://doi.org/10.1016/j.tranon.2023.101871

Trivanović D, Mojsilović S, Bogosavljević N, Jurišić V, Jauković A. Revealing profile of cancer-educated platelets and their factors to foster immunotherapy development. in Translational Oncology. 2024;40:101871.
doi:10.1016/j.tranon.2023.101871 .

Trivanović, Drenka, Mojsilović, Slavko, Bogosavljević, Nikola, Jurišić, Vladimir, Jauković, Aleksandra, "Revealing profile of cancer-educated platelets and their factors to foster immunotherapy development" in Translational Oncology, 40 (2024):101871,
https://doi.org/10.1016/j.tranon.2023.101871 . .

TY  - JOUR
AU  - Miletić, Maja
AU  - Puač, Nevena
AU  - Škoro, Nikola
AU  - Brković, Božidar
AU  - Andrić, Miroslav
AU  - Prokić, Bogomir Bolka
AU  - Danilović, Vesna
AU  - Milutinović-Smiljanić, Sanja
AU  - Mitrović-Ajtić, Olivera
AU  - Mojsilović, Slavko
PY  - 2024
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1464
AB  - In regenerative bone tissue medicine, combining artificial bone substitutes with progenitor cells is a prospective approach. Surface modification via cold atmospheric plasma (CAP) enhances biomaterial–cell interactions, which are crucial for successful bone regeneration. Using a rabbit calvarial critical-size defect model, we assessed the use of CAP-pretreated beta-tricalcium phosphate (β-TCP), alone or with periodontal ligament stem cells (PDLSCs), for bone regeneration. Histological and histomorphometric analyses at two and four weeks revealed significantly improved bone regeneration and reduced inflammation in the CAP-treated β-TCP with PDLSCs compared to β-TCP alone. Immunohistochemical analysis also showed an increase in the bone healing markers, including bone morphogenic proteins 2 and 4, runt-related transcription factor 2, collagen-1, and osteonectin, after two and four weeks in the CAP-treated β-TCP implants with PDLSC. This in vivo study demonstrates for the first time the superior bone regenerative capacity of CAP-pretreated β-TCP seeded with PDLSCs, highlighting the therapeutic potential of this combined approach in osteoregeneration.
T2  - Applied Sciences
T2  - Applied Sciences
T1  - Bone Regeneration Potential of Periodontal Ligament Stem Cells in Combination with Cold Atmospheric Plasma-Pretreated Beta-Tricalcium Phosphate: An In Vivo Assessment
IS  - 1
SP  - 16
VL  - 14
DO  - 10.3390/app14010016
ER  - 

@article{
author = "Miletić, Maja and Puač, Nevena and Škoro, Nikola and Brković, Božidar and Andrić, Miroslav and Prokić, Bogomir Bolka and Danilović, Vesna and Milutinović-Smiljanić, Sanja and Mitrović-Ajtić, Olivera and Mojsilović, Slavko",
year = "2024",
abstract = "In regenerative bone tissue medicine, combining artificial bone substitutes with progenitor cells is a prospective approach. Surface modification via cold atmospheric plasma (CAP) enhances biomaterial–cell interactions, which are crucial for successful bone regeneration. Using a rabbit calvarial critical-size defect model, we assessed the use of CAP-pretreated beta-tricalcium phosphate (β-TCP), alone or with periodontal ligament stem cells (PDLSCs), for bone regeneration. Histological and histomorphometric analyses at two and four weeks revealed significantly improved bone regeneration and reduced inflammation in the CAP-treated β-TCP with PDLSCs compared to β-TCP alone. Immunohistochemical analysis also showed an increase in the bone healing markers, including bone morphogenic proteins 2 and 4, runt-related transcription factor 2, collagen-1, and osteonectin, after two and four weeks in the CAP-treated β-TCP implants with PDLSC. This in vivo study demonstrates for the first time the superior bone regenerative capacity of CAP-pretreated β-TCP seeded with PDLSCs, highlighting the therapeutic potential of this combined approach in osteoregeneration.",
journal = "Applied Sciences, Applied Sciences",
title = "Bone Regeneration Potential of Periodontal Ligament Stem Cells in Combination with Cold Atmospheric Plasma-Pretreated Beta-Tricalcium Phosphate: An In Vivo Assessment",
number = "1",
pages = "16",
volume = "14",
doi = "10.3390/app14010016"
}

Miletić, M., Puač, N., Škoro, N., Brković, B., Andrić, M., Prokić, B. B., Danilović, V., Milutinović-Smiljanić, S., Mitrović-Ajtić, O.,& Mojsilović, S.. (2024). Bone Regeneration Potential of Periodontal Ligament Stem Cells in Combination with Cold Atmospheric Plasma-Pretreated Beta-Tricalcium Phosphate: An In Vivo Assessment. in Applied Sciences, 14(1), 16.
https://doi.org/10.3390/app14010016

Miletić M, Puač N, Škoro N, Brković B, Andrić M, Prokić BB, Danilović V, Milutinović-Smiljanić S, Mitrović-Ajtić O, Mojsilović S. Bone Regeneration Potential of Periodontal Ligament Stem Cells in Combination with Cold Atmospheric Plasma-Pretreated Beta-Tricalcium Phosphate: An In Vivo Assessment. in Applied Sciences. 2024;14(1):16.
doi:10.3390/app14010016 .

Miletić, Maja, Puač, Nevena, Škoro, Nikola, Brković, Božidar, Andrić, Miroslav, Prokić, Bogomir Bolka, Danilović, Vesna, Milutinović-Smiljanić, Sanja, Mitrović-Ajtić, Olivera, Mojsilović, Slavko, "Bone Regeneration Potential of Periodontal Ligament Stem Cells in Combination with Cold Atmospheric Plasma-Pretreated Beta-Tricalcium Phosphate: An In Vivo Assessment" in Applied Sciences, 14, no. 1 (2024):16,
https://doi.org/10.3390/app14010016 . .

TY  - JOUR
AU  - Paunović, Marija
AU  - Milošević, Maja
AU  - Mitrović-Ajtić, Olivera
AU  - Veličković, Nataša
AU  - Mićić, Bojana
AU  - Nedić, Olgica
AU  - Todorović, Vanja
AU  - Vučić, Vesna
AU  - Petrović, Snježana
PY  - 2024
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1476
AB  - Diets high in fat and sugar lead to metabolic syndrome (MetS) and related chronic diseases. We investigated the effects of commercially available, cold-pressed polyphenol-rich black currant (BC) and cornelian cherry (CC) juices on the prevention of MetS in Wistar rats induced by a 10-weeks high-fat high-fructose (HFF) diet. Juice consumption, either BC or CC, with a HFF diet resulted in lower serum triglycerides compared to only the HFF consumption. Both juices also mitigated the effects of HFF on the liver, pancreas, and adipose tissue, by preserving liver and pancreas histomorphology and reducing visceral fat and adipocyte size. Furthermore, supplementation with both juices reduced glucagon and up-regulated insulin expression in the pancreas of the rats on the HFF diet, whereas the BC also showed improved glucose regulation. BC juice also reduced the expression of IL-6 and hepatic inflammation compared to the group only on HFF diet. Both juices, especially BC, could be a convenient solution for the prevention of MetS in humans.
PB  - Elsevier
T2  - Heliyon
T1  - Polyphenol-rich black currant and cornelian cherry juices ameliorate metabolic syndrome induced by a high-fat high-fructose diet in Wistar rats
IS  - 7
SP  - e27709
VL  - 10
DO  - 10.1016/j.heliyon.2024.e27709
ER  - 

@article{
author = "Paunović, Marija and Milošević, Maja and Mitrović-Ajtić, Olivera and Veličković, Nataša and Mićić, Bojana and Nedić, Olgica and Todorović, Vanja and Vučić, Vesna and Petrović, Snježana",
year = "2024",
abstract = "Diets high in fat and sugar lead to metabolic syndrome (MetS) and related chronic diseases. We investigated the effects of commercially available, cold-pressed polyphenol-rich black currant (BC) and cornelian cherry (CC) juices on the prevention of MetS in Wistar rats induced by a 10-weeks high-fat high-fructose (HFF) diet. Juice consumption, either BC or CC, with a HFF diet resulted in lower serum triglycerides compared to only the HFF consumption. Both juices also mitigated the effects of HFF on the liver, pancreas, and adipose tissue, by preserving liver and pancreas histomorphology and reducing visceral fat and adipocyte size. Furthermore, supplementation with both juices reduced glucagon and up-regulated insulin expression in the pancreas of the rats on the HFF diet, whereas the BC also showed improved glucose regulation. BC juice also reduced the expression of IL-6 and hepatic inflammation compared to the group only on HFF diet. Both juices, especially BC, could be a convenient solution for the prevention of MetS in humans.",
publisher = "Elsevier",
journal = "Heliyon",
title = "Polyphenol-rich black currant and cornelian cherry juices ameliorate metabolic syndrome induced by a high-fat high-fructose diet in Wistar rats",
number = "7",
pages = "e27709",
volume = "10",
doi = "10.1016/j.heliyon.2024.e27709"
}

Paunović, M., Milošević, M., Mitrović-Ajtić, O., Veličković, N., Mićić, B., Nedić, O., Todorović, V., Vučić, V.,& Petrović, S.. (2024). Polyphenol-rich black currant and cornelian cherry juices ameliorate metabolic syndrome induced by a high-fat high-fructose diet in Wistar rats. in Heliyon
Elsevier., 10(7), e27709.
https://doi.org/10.1016/j.heliyon.2024.e27709

Paunović M, Milošević M, Mitrović-Ajtić O, Veličković N, Mićić B, Nedić O, Todorović V, Vučić V, Petrović S. Polyphenol-rich black currant and cornelian cherry juices ameliorate metabolic syndrome induced by a high-fat high-fructose diet in Wistar rats. in Heliyon. 2024;10(7):e27709.
doi:10.1016/j.heliyon.2024.e27709 .

Paunović, Marija, Milošević, Maja, Mitrović-Ajtić, Olivera, Veličković, Nataša, Mićić, Bojana, Nedić, Olgica, Todorović, Vanja, Vučić, Vesna, Petrović, Snježana, "Polyphenol-rich black currant and cornelian cherry juices ameliorate metabolic syndrome induced by a high-fat high-fructose diet in Wistar rats" in Heliyon, 10, no. 7 (2024):e27709,
https://doi.org/10.1016/j.heliyon.2024.e27709 . .

TY  - JOUR
AU  - Jain, Abhinav
AU  - De, Soumik
AU  - Saraswat, Pranjal
AU  - Haribabu, Jebiti
AU  - Santibanez, Juan F.
AU  - Barman, Pranjit
PY  - 2024
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1485
AB  - Designing economical and sensitive chemosensors for detecting important metal ions, like Cu2+ ions, is essential and remains a hot topic worldwide. In this investigation, we extended our investigation to design a specific diphenyl-azine-based skeletal system for the selective and sensitive detection of Cu2+ions. We reported a coumarin-diphenyl-azine-based AIEgen (C-1) using an improvised methodology with a large Stoke's shift (∼245 nm) for precisely sensing copper ions in solid, solution, and biological cells. The AIE-ESIPT properties of C-1 were validated using various sophisticated techniques. C-1 was found to be a promising selective and sensitive sensor of Cu2+ ions (nanomolar LOD value ∼10.38 nM) via colorimetric and TURNOFF fluorometric ways. The practical applicability of C-1 was analyzed via real-time estimation of copper ions in water samples (obtained from three varied locations) and in biological samples (urine and serum). The satisfactory recovery with a low RSD value indicates the potential of C-1 in detecting copper ions in actual samples. Estimating copper ions in urine and blood samples demonstrates the usefulness of C-1 in diagnosing disorders like Wilson's disease, which is caused by high concentrations of copper ions in the body. Additionally, we have detected Cu2+ions in live cells (HeLa cells) and carried out Latent Fingerprinting (Level 1 and Level 2) to validate its versatility in physiological and forensic applications. Overall, the proposed C-1 AIEgen is an ultrasensitive Cu2+ions sensor with innumerable applications in the physical world.
PB  - Elsevier
T2  - Journal of Molecular Structure
T1  - An ESIPT active coumarin-diphenyl azine-based AIEgen: Nanomolar Cu2+ ion sensing, Latent Fingerprinting, live-cell imaging, and real sample analysis
SP  - 138383
SP  - 138383
VL  - 1310
DO  - 10.1016/j.molstruc.2024.138383
ER  - 

@article{
author = "Jain, Abhinav and De, Soumik and Saraswat, Pranjal and Haribabu, Jebiti and Santibanez, Juan F. and Barman, Pranjit",
year = "2024",
abstract = "Designing economical and sensitive chemosensors for detecting important metal ions, like Cu2+ ions, is essential and remains a hot topic worldwide. In this investigation, we extended our investigation to design a specific diphenyl-azine-based skeletal system for the selective and sensitive detection of Cu2+ions. We reported a coumarin-diphenyl-azine-based AIEgen (C-1) using an improvised methodology with a large Stoke's shift (∼245 nm) for precisely sensing copper ions in solid, solution, and biological cells. The AIE-ESIPT properties of C-1 were validated using various sophisticated techniques. C-1 was found to be a promising selective and sensitive sensor of Cu2+ ions (nanomolar LOD value ∼10.38 nM) via colorimetric and TURNOFF fluorometric ways. The practical applicability of C-1 was analyzed via real-time estimation of copper ions in water samples (obtained from three varied locations) and in biological samples (urine and serum). The satisfactory recovery with a low RSD value indicates the potential of C-1 in detecting copper ions in actual samples. Estimating copper ions in urine and blood samples demonstrates the usefulness of C-1 in diagnosing disorders like Wilson's disease, which is caused by high concentrations of copper ions in the body. Additionally, we have detected Cu2+ions in live cells (HeLa cells) and carried out Latent Fingerprinting (Level 1 and Level 2) to validate its versatility in physiological and forensic applications. Overall, the proposed C-1 AIEgen is an ultrasensitive Cu2+ions sensor with innumerable applications in the physical world.",
publisher = "Elsevier",
journal = "Journal of Molecular Structure",
title = "An ESIPT active coumarin-diphenyl azine-based AIEgen: Nanomolar Cu2+ ion sensing, Latent Fingerprinting, live-cell imaging, and real sample analysis",
pages = "138383-138383",
volume = "1310",
doi = "10.1016/j.molstruc.2024.138383"
}

Jain, A., De, S., Saraswat, P., Haribabu, J., Santibanez, J. F.,& Barman, P.. (2024). An ESIPT active coumarin-diphenyl azine-based AIEgen: Nanomolar Cu2+ ion sensing, Latent Fingerprinting, live-cell imaging, and real sample analysis. in Journal of Molecular Structure
Elsevier., 1310, 138383.
https://doi.org/10.1016/j.molstruc.2024.138383

Jain A, De S, Saraswat P, Haribabu J, Santibanez JF, Barman P. An ESIPT active coumarin-diphenyl azine-based AIEgen: Nanomolar Cu2+ ion sensing, Latent Fingerprinting, live-cell imaging, and real sample analysis. in Journal of Molecular Structure. 2024;1310:138383.
doi:10.1016/j.molstruc.2024.138383 .

Jain, Abhinav, De, Soumik, Saraswat, Pranjal, Haribabu, Jebiti, Santibanez, Juan F., Barman, Pranjit, "An ESIPT active coumarin-diphenyl azine-based AIEgen: Nanomolar Cu2+ ion sensing, Latent Fingerprinting, live-cell imaging, and real sample analysis" in Journal of Molecular Structure, 1310 (2024):138383,
https://doi.org/10.1016/j.molstruc.2024.138383 . .

TY  - JOUR
AU  - Takić, Marija
AU  - Ranković, Slavica
AU  - Girek, Zdenka
AU  - Pavlović, Suzana
AU  - Jovanović, Petar
AU  - Jovanović, Vesna
AU  - Šarac, Ivana
PY  - 2024
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1483
AB  - The plant-derived α-linolenic acid (ALA) is an essential n-3 acid highly susceptible to oxidation, present in oils of flaxseeds, walnuts, canola, perilla, soy, and chia. After ingestion, it can be incorporated in to body lipid pools (particularly triglycerides and phospholipid membranes), and then endogenously metabolized through desaturation, elongation, and peroxisome oxidation to eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), with a very limited efficiency (particularly for DHA), beta-oxidized as an energy source, or directly metabolized to C18-oxilipins. At this moment, data in the literature about the effects of ALA supplementation on metabolic syndrome (MetS) in humans are inconsistent, indicating no effects or some positive effects on all MetS components (abdominal obesity, dyslipidemia, impaired insulin sensitivity and glucoregulation, blood pressure, and liver steatosis). The major effects of ALA on MetS seem to be through its conversion to more potent EPA and DHA, the impact on the n-3/n-6 ratio, and the consecutive effects on the formation of oxylipins and endocannabinoids, inflammation, insulin sensitivity, and insulin secretion, as well as adipocyte and hepatocytes function. It is important to distinguish the direct effects of ALA from the effects of EPA and DHA metabolites. This review summarizes the most recent findings on this topic and discusses the possible mechanisms.
PB  - Basel : MDPI (Multidisciplinary Digital Publishing Institute)
T2  - International Journal of Molecular Sciences
T2  - International Journal of Molecular Sciences
T1  - Current Insights into the Effects of Dietary α-Linolenic Acid Focusing on Alterations of Polyunsaturated Fatty Acid Profiles in Metabolic Syndrome
IS  - 9
SP  - 4909
VL  - 25
DO  - 10.3390/ijms25094909
ER  - 

@article{
author = "Takić, Marija and Ranković, Slavica and Girek, Zdenka and Pavlović, Suzana and Jovanović, Petar and Jovanović, Vesna and Šarac, Ivana",
year = "2024",
abstract = "The plant-derived α-linolenic acid (ALA) is an essential n-3 acid highly susceptible to oxidation, present in oils of flaxseeds, walnuts, canola, perilla, soy, and chia. After ingestion, it can be incorporated in to body lipid pools (particularly triglycerides and phospholipid membranes), and then endogenously metabolized through desaturation, elongation, and peroxisome oxidation to eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), with a very limited efficiency (particularly for DHA), beta-oxidized as an energy source, or directly metabolized to C18-oxilipins. At this moment, data in the literature about the effects of ALA supplementation on metabolic syndrome (MetS) in humans are inconsistent, indicating no effects or some positive effects on all MetS components (abdominal obesity, dyslipidemia, impaired insulin sensitivity and glucoregulation, blood pressure, and liver steatosis). The major effects of ALA on MetS seem to be through its conversion to more potent EPA and DHA, the impact on the n-3/n-6 ratio, and the consecutive effects on the formation of oxylipins and endocannabinoids, inflammation, insulin sensitivity, and insulin secretion, as well as adipocyte and hepatocytes function. It is important to distinguish the direct effects of ALA from the effects of EPA and DHA metabolites. This review summarizes the most recent findings on this topic and discusses the possible mechanisms.",
publisher = "Basel : MDPI (Multidisciplinary Digital Publishing Institute)",
journal = "International Journal of Molecular Sciences, International Journal of Molecular Sciences",
title = "Current Insights into the Effects of Dietary α-Linolenic Acid Focusing on Alterations of Polyunsaturated Fatty Acid Profiles in Metabolic Syndrome",
number = "9",
pages = "4909",
volume = "25",
doi = "10.3390/ijms25094909"
}

Takić, M., Ranković, S., Girek, Z., Pavlović, S., Jovanović, P., Jovanović, V.,& Šarac, I.. (2024). Current Insights into the Effects of Dietary α-Linolenic Acid Focusing on Alterations of Polyunsaturated Fatty Acid Profiles in Metabolic Syndrome. in International Journal of Molecular Sciences
Basel : MDPI (Multidisciplinary Digital Publishing Institute)., 25(9), 4909.
https://doi.org/10.3390/ijms25094909

Takić M, Ranković S, Girek Z, Pavlović S, Jovanović P, Jovanović V, Šarac I. Current Insights into the Effects of Dietary α-Linolenic Acid Focusing on Alterations of Polyunsaturated Fatty Acid Profiles in Metabolic Syndrome. in International Journal of Molecular Sciences. 2024;25(9):4909.
doi:10.3390/ijms25094909 .

Takić, Marija, Ranković, Slavica, Girek, Zdenka, Pavlović, Suzana, Jovanović, Petar, Jovanović, Vesna, Šarac, Ivana, "Current Insights into the Effects of Dietary α-Linolenic Acid Focusing on Alterations of Polyunsaturated Fatty Acid Profiles in Metabolic Syndrome" in International Journal of Molecular Sciences, 25, no. 9 (2024):4909,
https://doi.org/10.3390/ijms25094909 . .

TY  - JOUR
AU  - Paunović, Marija
AU  - Ristić-Medić, Danijela
AU  - Arsić, Aleksandra
AU  - Petrović, Snježana
AU  - Krstić, Predrag
AU  - Kojadinović, Milica
AU  - Vučić, Vesna
PY  - 2024
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1482
AB  - Background/Aim. Since the coronavirus disease 2019 (COVID-19) pandemic led to a strict lockdown in Serbia, the population has experienced drastic lifestyle changes. Physical distancing, self-isolation, limited availability of essential food products, and the stress related to the availability of therapy during the pandemic particularly affected the lives of vulnerable groups, such as breast cancer (BrC) patients. The aim of this study was to examine the changes in eating behaviors and physical activity of postmenopausal BrC patients on adjuvant hormonal therapy under the COVID-19 lockdown conditions. Methods. This observational retrospective pre-post cohort study included 32 women treated with aromatase inhibitors (AIs) who responded to telephone interviews using a structured questionnaire. The questionnaire aims to collect data on eating habits (intake of certain foods on a daily/weekly basis, as well as changes in the usual choice of food), intake of supplements, changes in weight, and physical activity before and during the lockdown. Results. The results showed that, due to problems in obtaining groceries, the patients cooked and consumed homemade sweets and fruit more often (47% of the respondents), while fewer (31%) consumed fresh fish. Nearly 41% of patients reported increased food intake, and 88% reported decreased physical activity, which led to an increase in body weight in as many as 47% of subjects. The intake of supplements was doubled. Conclusion. The COVID-19 lockdown with home confinement exacerbated health risks and affected dietary patterns and physical activity, which may have had a negative impact on the long-term health of BrC patients treated with AIs.
PB  - Military Medical Academy, INI
T2  - Vojnosanitetski pregled
T2  - Vojnosanitetski pregled
T1  - Eating behaviors and physical activity during the COVID-19 pandemic lockdown: Experiences of breast cancer patients on adjuvant hormonal therapy
EP  - xx
IS  - 00
SP  - xx
DO  - 10.2298/VSP231122020P
ER  - 

@article{
author = "Paunović, Marija and Ristić-Medić, Danijela and Arsić, Aleksandra and Petrović, Snježana and Krstić, Predrag and Kojadinović, Milica and Vučić, Vesna",
year = "2024",
abstract = "Background/Aim. Since the coronavirus disease 2019 (COVID-19) pandemic led to a strict lockdown in Serbia, the population has experienced drastic lifestyle changes. Physical distancing, self-isolation, limited availability of essential food products, and the stress related to the availability of therapy during the pandemic particularly affected the lives of vulnerable groups, such as breast cancer (BrC) patients. The aim of this study was to examine the changes in eating behaviors and physical activity of postmenopausal BrC patients on adjuvant hormonal therapy under the COVID-19 lockdown conditions. Methods. This observational retrospective pre-post cohort study included 32 women treated with aromatase inhibitors (AIs) who responded to telephone interviews using a structured questionnaire. The questionnaire aims to collect data on eating habits (intake of certain foods on a daily/weekly basis, as well as changes in the usual choice of food), intake of supplements, changes in weight, and physical activity before and during the lockdown. Results. The results showed that, due to problems in obtaining groceries, the patients cooked and consumed homemade sweets and fruit more often (47% of the respondents), while fewer (31%) consumed fresh fish. Nearly 41% of patients reported increased food intake, and 88% reported decreased physical activity, which led to an increase in body weight in as many as 47% of subjects. The intake of supplements was doubled. Conclusion. The COVID-19 lockdown with home confinement exacerbated health risks and affected dietary patterns and physical activity, which may have had a negative impact on the long-term health of BrC patients treated with AIs.",
publisher = "Military Medical Academy, INI",
journal = "Vojnosanitetski pregled, Vojnosanitetski pregled",
title = "Eating behaviors and physical activity during the COVID-19 pandemic lockdown: Experiences of breast cancer patients on adjuvant hormonal therapy",
pages = "xx-xx",
number = "00",
doi = "10.2298/VSP231122020P"
}

Paunović, M., Ristić-Medić, D., Arsić, A., Petrović, S., Krstić, P., Kojadinović, M.,& Vučić, V.. (2024). Eating behaviors and physical activity during the COVID-19 pandemic lockdown: Experiences of breast cancer patients on adjuvant hormonal therapy. in Vojnosanitetski pregled
Military Medical Academy, INI.(00), xx-xx.
https://doi.org/10.2298/VSP231122020P

Paunović M, Ristić-Medić D, Arsić A, Petrović S, Krstić P, Kojadinović M, Vučić V. Eating behaviors and physical activity during the COVID-19 pandemic lockdown: Experiences of breast cancer patients on adjuvant hormonal therapy. in Vojnosanitetski pregled. 2024;(00):xx-xx.
doi:10.2298/VSP231122020P .

Paunović, Marija, Ristić-Medić, Danijela, Arsić, Aleksandra, Petrović, Snježana, Krstić, Predrag, Kojadinović, Milica, Vučić, Vesna, "Eating behaviors and physical activity during the COVID-19 pandemic lockdown: Experiences of breast cancer patients on adjuvant hormonal therapy" in Vojnosanitetski pregled, no. 00 (2024):xx-xx,
https://doi.org/10.2298/VSP231122020P . .

TY  - JOUR
AU  - Cabreira, Verónica
AU  - Alty, Jane
AU  - Antić, Sonja
AU  - Araújo, Rui
AU  - Aybek, Selma
AU  - Ball, Harriet A.
AU  - Baslet, Gaston
AU  - Bhome, Rohan
AU  - Coebergh, Jan
AU  - Dubois, Bruno
AU  - Edwards, Mark
AU  - Filipović, Saša
AU  - Frederiksen, Kristian Steen
AU  - Harbo, Thomas
AU  - Hayhow, Bradleigh
AU  - Howard, Robert
AU  - Huntley, Jonathan
AU  - Isaacs, Jeremy
AU  - LaFrance Jr., William Curt
AU  - Larner, Andrew J.
AU  - Di Lorenzo, Francesco
AU  - Main, James
AU  - Mallam, Elizabeth
AU  - Marra, Camillo
AU  - Massano, João
AU  - McGrath, Emer R.
AU  - McWhirter, Laura
AU  - Moreira, Isabel Portela
AU  - Nobili, Flavio
AU  - Pennington, Catherine
AU  - Tábuas-Pereira, Miguel
AU  - Perez, David L.
AU  - Popkirov, Stoyan
AU  - Rayment, Dane
AU  - Rossor, Martin
AU  - Russo, Mirella
AU  - Santana, Isabel
AU  - Schott, Jonathan
AU  - Scott, Emmi P.
AU  - Taipa, Ricardo
AU  - Tinazzi, Michele
AU  - Tomić, Svetlana
AU  - Toniolo, Sofia
AU  - Tørring, Caroline Winther
AU  - Wilkinson, Tim
AU  - Frostholm, Lisbeth
AU  - Stone, Jon
AU  - Carson, Alan
PY  - 2024
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1481
AB  - Background: Current proposed criteria for functional cognitive disorder (FCD) have not been externally validated. We sought to analyse the current perspectives of cognitive specialists in the diagnosis and management of FCD in comparison with neurodegenerative conditions. Methods: International experts in cognitive disorders were invited to assess seven illustrative clinical vignettes containing history and bedside characteristics alone. Participants assigned a probable diagnosis and selected the appropriate investigation and treatment. Qualitative, quantitative and inter-rater agreement analyses were undertaken. Results: Eighteen diagnostic terminologies were assigned by 45 cognitive experts from 12 countries with a median of 13 years of experience, across the seven scenarios. Accurate discrimination between FCD and neurodegeneration was observed, independently of background and years of experience: 100% of the neurodegenerative vignettes were correctly classified and 75%–88% of the FCD diagnoses were attributed to non-neurodegenerative causes. There was <50% agreement in the terminology used for FCD, in comparison with 87%–92% agreement for neurodegenerative syndromes. Blood tests and neuropsychological evaluation were the leading diagnostic modalities for FCD. Diagnostic communication, psychotherapy and psychiatry referral were the main suggested management strategies in FCD. Conclusions: Our study demonstrates the feasibility of distinguishing between FCD and neurodegeneration based on relevant patient characteristics and history details. These characteristics need further validation and operationalisation. Heterogeneous labelling and framing pose clinical and research challenges reflecting a lack of agreement in the field. Careful consideration of FCD diagnosis is advised, particularly in the presence of comorbidities. This study informs future research on diagnostic tools and evidence-based interventions.
PB  - Wiley-Blackwell
T2  - European Journal of Neurology
T2  - European Journal of Neurology
T1  - Perspectives on the diagnosis and management of functional cognitive disorder: An international Delphi study
IS  - n/a
SP  - e16318
VL  - n/a
DO  - 10.1111/ene.16318
ER  - 

@article{
author = "Cabreira, Verónica and Alty, Jane and Antić, Sonja and Araújo, Rui and Aybek, Selma and Ball, Harriet A. and Baslet, Gaston and Bhome, Rohan and Coebergh, Jan and Dubois, Bruno and Edwards, Mark and Filipović, Saša and Frederiksen, Kristian Steen and Harbo, Thomas and Hayhow, Bradleigh and Howard, Robert and Huntley, Jonathan and Isaacs, Jeremy and LaFrance Jr., William Curt and Larner, Andrew J. and Di Lorenzo, Francesco and Main, James and Mallam, Elizabeth and Marra, Camillo and Massano, João and McGrath, Emer R. and McWhirter, Laura and Moreira, Isabel Portela and Nobili, Flavio and Pennington, Catherine and Tábuas-Pereira, Miguel and Perez, David L. and Popkirov, Stoyan and Rayment, Dane and Rossor, Martin and Russo, Mirella and Santana, Isabel and Schott, Jonathan and Scott, Emmi P. and Taipa, Ricardo and Tinazzi, Michele and Tomić, Svetlana and Toniolo, Sofia and Tørring, Caroline Winther and Wilkinson, Tim and Frostholm, Lisbeth and Stone, Jon and Carson, Alan",
year = "2024",
abstract = "Background: Current proposed criteria for functional cognitive disorder (FCD) have not been externally validated. We sought to analyse the current perspectives of cognitive specialists in the diagnosis and management of FCD in comparison with neurodegenerative conditions. Methods: International experts in cognitive disorders were invited to assess seven illustrative clinical vignettes containing history and bedside characteristics alone. Participants assigned a probable diagnosis and selected the appropriate investigation and treatment. Qualitative, quantitative and inter-rater agreement analyses were undertaken. Results: Eighteen diagnostic terminologies were assigned by 45 cognitive experts from 12 countries with a median of 13 years of experience, across the seven scenarios. Accurate discrimination between FCD and neurodegeneration was observed, independently of background and years of experience: 100% of the neurodegenerative vignettes were correctly classified and 75%–88% of the FCD diagnoses were attributed to non-neurodegenerative causes. There was <50% agreement in the terminology used for FCD, in comparison with 87%–92% agreement for neurodegenerative syndromes. Blood tests and neuropsychological evaluation were the leading diagnostic modalities for FCD. Diagnostic communication, psychotherapy and psychiatry referral were the main suggested management strategies in FCD. Conclusions: Our study demonstrates the feasibility of distinguishing between FCD and neurodegeneration based on relevant patient characteristics and history details. These characteristics need further validation and operationalisation. Heterogeneous labelling and framing pose clinical and research challenges reflecting a lack of agreement in the field. Careful consideration of FCD diagnosis is advised, particularly in the presence of comorbidities. This study informs future research on diagnostic tools and evidence-based interventions.",
publisher = "Wiley-Blackwell",
journal = "European Journal of Neurology, European Journal of Neurology",
title = "Perspectives on the diagnosis and management of functional cognitive disorder: An international Delphi study",
number = "n/a",
pages = "e16318",
volume = "n/a",
doi = "10.1111/ene.16318"
}

Cabreira, V., Alty, J., Antić, S., Araújo, R., Aybek, S., Ball, H. A., Baslet, G., Bhome, R., Coebergh, J., Dubois, B., Edwards, M., Filipović, S., Frederiksen, K. S., Harbo, T., Hayhow, B., Howard, R., Huntley, J., Isaacs, J., LaFrance Jr., W. C., Larner, A. J., Di Lorenzo, F., Main, J., Mallam, E., Marra, C., Massano, J., McGrath, E. R., McWhirter, L., Moreira, I. P., Nobili, F., Pennington, C., Tábuas-Pereira, M., Perez, D. L., Popkirov, S., Rayment, D., Rossor, M., Russo, M., Santana, I., Schott, J., Scott, E. P., Taipa, R., Tinazzi, M., Tomić, S., Toniolo, S., Tørring, C. W., Wilkinson, T., Frostholm, L., Stone, J.,& Carson, A.. (2024). Perspectives on the diagnosis and management of functional cognitive disorder: An international Delphi study. in European Journal of Neurology
Wiley-Blackwell., n/a(n/a), e16318.
https://doi.org/10.1111/ene.16318

Cabreira V, Alty J, Antić S, Araújo R, Aybek S, Ball HA, Baslet G, Bhome R, Coebergh J, Dubois B, Edwards M, Filipović S, Frederiksen KS, Harbo T, Hayhow B, Howard R, Huntley J, Isaacs J, LaFrance Jr. WC, Larner AJ, Di Lorenzo F, Main J, Mallam E, Marra C, Massano J, McGrath ER, McWhirter L, Moreira IP, Nobili F, Pennington C, Tábuas-Pereira M, Perez DL, Popkirov S, Rayment D, Rossor M, Russo M, Santana I, Schott J, Scott EP, Taipa R, Tinazzi M, Tomić S, Toniolo S, Tørring CW, Wilkinson T, Frostholm L, Stone J, Carson A. Perspectives on the diagnosis and management of functional cognitive disorder: An international Delphi study. in European Journal of Neurology. 2024;n/a(n/a):e16318.
doi:10.1111/ene.16318 .

Cabreira, Verónica, Alty, Jane, Antić, Sonja, Araújo, Rui, Aybek, Selma, Ball, Harriet A., Baslet, Gaston, Bhome, Rohan, Coebergh, Jan, Dubois, Bruno, Edwards, Mark, Filipović, Saša, Frederiksen, Kristian Steen, Harbo, Thomas, Hayhow, Bradleigh, Howard, Robert, Huntley, Jonathan, Isaacs, Jeremy, LaFrance Jr., William Curt, Larner, Andrew J., Di Lorenzo, Francesco, Main, James, Mallam, Elizabeth, Marra, Camillo, Massano, João, McGrath, Emer R., McWhirter, Laura, Moreira, Isabel Portela, Nobili, Flavio, Pennington, Catherine, Tábuas-Pereira, Miguel, Perez, David L., Popkirov, Stoyan, Rayment, Dane, Rossor, Martin, Russo, Mirella, Santana, Isabel, Schott, Jonathan, Scott, Emmi P., Taipa, Ricardo, Tinazzi, Michele, Tomić, Svetlana, Toniolo, Sofia, Tørring, Caroline Winther, Wilkinson, Tim, Frostholm, Lisbeth, Stone, Jon, Carson, Alan, "Perspectives on the diagnosis and management of functional cognitive disorder: An international Delphi study" in European Journal of Neurology, n/a, no. n/a (2024):e16318,
https://doi.org/10.1111/ene.16318 . .

TY  - JOUR
AU  - Antal, Andrea
AU  - Ganho-Ávila, Ana
AU  - Assecondi, Sara
AU  - Barbour, Tracy
AU  - Bjekić, Jovana
AU  - Blumberger, Daniel M.
AU  - Bolognini, Nadia
AU  - Brunelin, Jerome
AU  - Chanes, Lorena
AU  - Dale, Matthew
AU  - Dubbioso, Raffaele
AU  - D'Urso, Giordano
AU  - Filipčić, Igor
AU  - Filipović, Saša
AU  - Hirnstein, Marco
AU  - Konings, Femke
AU  - Langguth, Berthold
AU  - Leocani, Letizia
AU  - Sorkhabi, Majid Memarian
AU  - Mulder, Marc
AU  - Nikander, Mika
AU  - Nowak, Rafal
AU  - Oliviero, Antonio
AU  - Onarheim, Balder
AU  - O'Shea, Jacinta
AU  - Pallanti, Stefano
AU  - Rachid, Fady
AU  - Rajão-Saraiva, Joana
AU  - Rossi, Simone
AU  - Sack, Alexander T.
AU  - Sauvaget, Anne
AU  - van der Scheer, Rik
AU  - Schellhorn, Klaus
AU  - Soria-Frisch, Aureli
AU  - Szekely, David
AU  - Tankisi, Hatice
AU  - CJ. Taylor, Paul
AU  - Tendolkar, Indira
AU  - Uusitalo, Susanne
AU  - Baeken, Chris
PY  - 2024
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1479
AB  - A significant amount of European basic and clinical neuroscience research includes the use of transcranial magnetic stimulation (TMS) and low intensity transcranial electrical stimulation (tES), mainly transcranial direct current stimulation (tDCS). Two recent changes in the EU regulations, the introduction of the Medical Device Regulation (MDR) (2017/745) and the Annex XVI have caused significant problems and confusions in the brain stimulation field. The negative consequences of the MDR for non-invasive brain stimulation (NIBS) have been largely overlooked and until today, have not been consequently addressed by National Competent Authorities, local ethical committees, politicians and by the scientific communities. In addition, a rushed bureaucratic decision led to seemingly wrong classification of NIBS products without an intended medical purpose into the same risk group III as invasive stimulators. Overregulation is detrimental for any research and for future developments, therefore researchers, clinicians, industry, patient representatives and an ethicist were invited to contribute to this document with the aim of starting a constructive dialogue and enacting positive changes in the regulatory environment.
PB  - Elsevier
T2  - Clinical Neurophysiology
T1  - The consequences of the new European reclassification of non-invasive brain stimulation devices and the medical device regulations pose an existential threat to research and treatment: An invited opinion paper
DO  - 10.1016/j.clinph.2024.03.039
ER  - 

@article{
author = "Antal, Andrea and Ganho-Ávila, Ana and Assecondi, Sara and Barbour, Tracy and Bjekić, Jovana and Blumberger, Daniel M. and Bolognini, Nadia and Brunelin, Jerome and Chanes, Lorena and Dale, Matthew and Dubbioso, Raffaele and D'Urso, Giordano and Filipčić, Igor and Filipović, Saša and Hirnstein, Marco and Konings, Femke and Langguth, Berthold and Leocani, Letizia and Sorkhabi, Majid Memarian and Mulder, Marc and Nikander, Mika and Nowak, Rafal and Oliviero, Antonio and Onarheim, Balder and O'Shea, Jacinta and Pallanti, Stefano and Rachid, Fady and Rajão-Saraiva, Joana and Rossi, Simone and Sack, Alexander T. and Sauvaget, Anne and van der Scheer, Rik and Schellhorn, Klaus and Soria-Frisch, Aureli and Szekely, David and Tankisi, Hatice and CJ. Taylor, Paul and Tendolkar, Indira and Uusitalo, Susanne and Baeken, Chris",
year = "2024",
abstract = "A significant amount of European basic and clinical neuroscience research includes the use of transcranial magnetic stimulation (TMS) and low intensity transcranial electrical stimulation (tES), mainly transcranial direct current stimulation (tDCS). Two recent changes in the EU regulations, the introduction of the Medical Device Regulation (MDR) (2017/745) and the Annex XVI have caused significant problems and confusions in the brain stimulation field. The negative consequences of the MDR for non-invasive brain stimulation (NIBS) have been largely overlooked and until today, have not been consequently addressed by National Competent Authorities, local ethical committees, politicians and by the scientific communities. In addition, a rushed bureaucratic decision led to seemingly wrong classification of NIBS products without an intended medical purpose into the same risk group III as invasive stimulators. Overregulation is detrimental for any research and for future developments, therefore researchers, clinicians, industry, patient representatives and an ethicist were invited to contribute to this document with the aim of starting a constructive dialogue and enacting positive changes in the regulatory environment.",
publisher = "Elsevier",
journal = "Clinical Neurophysiology",
title = "The consequences of the new European reclassification of non-invasive brain stimulation devices and the medical device regulations pose an existential threat to research and treatment: An invited opinion paper",
doi = "10.1016/j.clinph.2024.03.039"
}

Antal, A., Ganho-Ávila, A., Assecondi, S., Barbour, T., Bjekić, J., Blumberger, D. M., Bolognini, N., Brunelin, J., Chanes, L., Dale, M., Dubbioso, R., D'Urso, G., Filipčić, I., Filipović, S., Hirnstein, M., Konings, F., Langguth, B., Leocani, L., Sorkhabi, M. M., Mulder, M., Nikander, M., Nowak, R., Oliviero, A., Onarheim, B., O'Shea, J., Pallanti, S., Rachid, F., Rajão-Saraiva, J., Rossi, S., Sack, A. T., Sauvaget, A., van der Scheer, R., Schellhorn, K., Soria-Frisch, A., Szekely, D., Tankisi, H., CJ. Taylor, P., Tendolkar, I., Uusitalo, S.,& Baeken, C.. (2024). The consequences of the new European reclassification of non-invasive brain stimulation devices and the medical device regulations pose an existential threat to research and treatment: An invited opinion paper. in Clinical Neurophysiology
Elsevier..
https://doi.org/10.1016/j.clinph.2024.03.039

Antal A, Ganho-Ávila A, Assecondi S, Barbour T, Bjekić J, Blumberger DM, Bolognini N, Brunelin J, Chanes L, Dale M, Dubbioso R, D'Urso G, Filipčić I, Filipović S, Hirnstein M, Konings F, Langguth B, Leocani L, Sorkhabi MM, Mulder M, Nikander M, Nowak R, Oliviero A, Onarheim B, O'Shea J, Pallanti S, Rachid F, Rajão-Saraiva J, Rossi S, Sack AT, Sauvaget A, van der Scheer R, Schellhorn K, Soria-Frisch A, Szekely D, Tankisi H, CJ. Taylor P, Tendolkar I, Uusitalo S, Baeken C. The consequences of the new European reclassification of non-invasive brain stimulation devices and the medical device regulations pose an existential threat to research and treatment: An invited opinion paper. in Clinical Neurophysiology. 2024;.
doi:10.1016/j.clinph.2024.03.039 .

Antal, Andrea, Ganho-Ávila, Ana, Assecondi, Sara, Barbour, Tracy, Bjekić, Jovana, Blumberger, Daniel M., Bolognini, Nadia, Brunelin, Jerome, Chanes, Lorena, Dale, Matthew, Dubbioso, Raffaele, D'Urso, Giordano, Filipčić, Igor, Filipović, Saša, Hirnstein, Marco, Konings, Femke, Langguth, Berthold, Leocani, Letizia, Sorkhabi, Majid Memarian, Mulder, Marc, Nikander, Mika, Nowak, Rafal, Oliviero, Antonio, Onarheim, Balder, O'Shea, Jacinta, Pallanti, Stefano, Rachid, Fady, Rajão-Saraiva, Joana, Rossi, Simone, Sack, Alexander T., Sauvaget, Anne, van der Scheer, Rik, Schellhorn, Klaus, Soria-Frisch, Aureli, Szekely, David, Tankisi, Hatice, CJ. Taylor, Paul, Tendolkar, Indira, Uusitalo, Susanne, Baeken, Chris, "The consequences of the new European reclassification of non-invasive brain stimulation devices and the medical device regulations pose an existential threat to research and treatment: An invited opinion paper" in Clinical Neurophysiology (2024),
https://doi.org/10.1016/j.clinph.2024.03.039 . .

TY  - JOUR
AU  - Rakuša, Martin
AU  - Moro, Elena
AU  - Akhvlediani, Tamar
AU  - Bereczki, Daniel
AU  - Bodini, Benedetta
AU  - Cavallieri, Francesco
AU  - Fanciulli, Alessandra
AU  - Filipović, Saša
AU  - Guekht, Alla
AU  - Helbok, Raimund
AU  - Hochmeister, Sonja
AU  - Martinelli Boneschi, Filippo
AU  - Özturk, Serefnur
AU  - Priori, Alberto
AU  - Romoli, Michele
AU  - Willekens, Barbara
AU  - Zedde, Marialuisa
AU  - Sellner, Johann
PY  - 2024
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1398
AB  - Background and Purpose The COVID-19 pandemic has significantly impacted health systems worldwide. Here, we assessed the pandemic's impact on clinical service, curricular training, and financial burden from a neurological viewpoint during the enforced lockdown periods and the assumed recovery by 2023. Methods An online 18-item survey was conducted by the European Academy of Neurology (EAN) NeuroCOVID-19 Task Force among the EAN community. The survey was online between February and March 2023. Questions related to general, demographic, clinical, work, education, and economic aspects. Results We collected 430 responses from 79 countries. Most health care professionals were aged 35–44 years, with >15 years of work experience. The key findings of their observations were as follows. (i) Clinical services were cut back in all neurological subspecialties during the most restrictive COVID-19 lockdown period. The most affected neurological subspecialties were services for patients with dementia, and neuromuscular and movement disorders. The levels of reduction and the pace of recovery were distinct for acute emergencies and in- and outpatient care. Recovery was slow for sleep medicine, autonomic nervous system disorders, neurorehabilitation, and dementia care. (ii) Student and residency rotations and grand rounds were reorganized, and congresses were converted into a virtual format. Conferences are partly maintained in a hybrid format. (iii) Affordability of neurological care and medication shortage are emerging issues. Conclusions Recovery of neurological services up to spring 2023 has been incomplete following substantial disruption of neurological care, medical education, and health economics in the wake of the COVID-19 pandemic. The continued limitations for the delivery of neurological care threaten brain health and call for action on a global scale.
PB  - Wiley-Blackwell
T2  - European Journal of Neurology
T1  - The COVID-19 pandemic and neurology: A survey on previous and continued restrictions for clinical practice, curricular training, and health economics
IS  - 3
SP  - e16168
VL  - 31
DO  - 10.1111/ene.16168
ER  - 

@article{
author = "Rakuša, Martin and Moro, Elena and Akhvlediani, Tamar and Bereczki, Daniel and Bodini, Benedetta and Cavallieri, Francesco and Fanciulli, Alessandra and Filipović, Saša and Guekht, Alla and Helbok, Raimund and Hochmeister, Sonja and Martinelli Boneschi, Filippo and Özturk, Serefnur and Priori, Alberto and Romoli, Michele and Willekens, Barbara and Zedde, Marialuisa and Sellner, Johann",
year = "2024",
abstract = "Background and Purpose The COVID-19 pandemic has significantly impacted health systems worldwide. Here, we assessed the pandemic's impact on clinical service, curricular training, and financial burden from a neurological viewpoint during the enforced lockdown periods and the assumed recovery by 2023. Methods An online 18-item survey was conducted by the European Academy of Neurology (EAN) NeuroCOVID-19 Task Force among the EAN community. The survey was online between February and March 2023. Questions related to general, demographic, clinical, work, education, and economic aspects. Results We collected 430 responses from 79 countries. Most health care professionals were aged 35–44 years, with >15 years of work experience. The key findings of their observations were as follows. (i) Clinical services were cut back in all neurological subspecialties during the most restrictive COVID-19 lockdown period. The most affected neurological subspecialties were services for patients with dementia, and neuromuscular and movement disorders. The levels of reduction and the pace of recovery were distinct for acute emergencies and in- and outpatient care. Recovery was slow for sleep medicine, autonomic nervous system disorders, neurorehabilitation, and dementia care. (ii) Student and residency rotations and grand rounds were reorganized, and congresses were converted into a virtual format. Conferences are partly maintained in a hybrid format. (iii) Affordability of neurological care and medication shortage are emerging issues. Conclusions Recovery of neurological services up to spring 2023 has been incomplete following substantial disruption of neurological care, medical education, and health economics in the wake of the COVID-19 pandemic. The continued limitations for the delivery of neurological care threaten brain health and call for action on a global scale.",
publisher = "Wiley-Blackwell",
journal = "European Journal of Neurology",
title = "The COVID-19 pandemic and neurology: A survey on previous and continued restrictions for clinical practice, curricular training, and health economics",
number = "3",
pages = "e16168",
volume = "31",
doi = "10.1111/ene.16168"
}

Rakuša, M., Moro, E., Akhvlediani, T., Bereczki, D., Bodini, B., Cavallieri, F., Fanciulli, A., Filipović, S., Guekht, A., Helbok, R., Hochmeister, S., Martinelli Boneschi, F., Özturk, S., Priori, A., Romoli, M., Willekens, B., Zedde, M.,& Sellner, J.. (2024). The COVID-19 pandemic and neurology: A survey on previous and continued restrictions for clinical practice, curricular training, and health economics. in European Journal of Neurology
Wiley-Blackwell., 31(3), e16168.
https://doi.org/10.1111/ene.16168

Rakuša M, Moro E, Akhvlediani T, Bereczki D, Bodini B, Cavallieri F, Fanciulli A, Filipović S, Guekht A, Helbok R, Hochmeister S, Martinelli Boneschi F, Özturk S, Priori A, Romoli M, Willekens B, Zedde M, Sellner J. The COVID-19 pandemic and neurology: A survey on previous and continued restrictions for clinical practice, curricular training, and health economics. in European Journal of Neurology. 2024;31(3):e16168.
doi:10.1111/ene.16168 .

Rakuša, Martin, Moro, Elena, Akhvlediani, Tamar, Bereczki, Daniel, Bodini, Benedetta, Cavallieri, Francesco, Fanciulli, Alessandra, Filipović, Saša, Guekht, Alla, Helbok, Raimund, Hochmeister, Sonja, Martinelli Boneschi, Filippo, Özturk, Serefnur, Priori, Alberto, Romoli, Michele, Willekens, Barbara, Zedde, Marialuisa, Sellner, Johann, "The COVID-19 pandemic and neurology: A survey on previous and continued restrictions for clinical practice, curricular training, and health economics" in European Journal of Neurology, 31, no. 3 (2024):e16168,
https://doi.org/10.1111/ene.16168 . .

TY  - JOUR
AU  - Rodriguez-Porcel, Federico
AU  - Sarva, Harini
AU  - Joutsa, Juho
AU  - Falup-Pecurariu, Cristian
AU  - Wagle Shukla, Aparna
AU  - Mehanna, Raja
AU  - Śmiłowska, Katarzyna
AU  - Lanza, Giuseppe
AU  - Filipović, Saša
AU  - Shalash, Ali
AU  - Ferris, Margaret
AU  - Jankovic, Joseph
AU  - Espay, Alberto J.
AU  - Pandey, Sanjay
PY  - 2024
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1459
AB  - Background: Post-stroke movement disorders (PSMD) encompass a wide array of presentations, which vary in mode of onset, phenomenology, response to treatment, and natural history. There are no evidence-based guidelines on the diagnosis and treatment of PSMD. Objectives: To survey current opinions and practices on the diagnosis and treatment of PSMD. Methods: A survey was developed by the PSMD Study Group, commissioned by the International Parkinson's and Movement Disorders Society (MDS). The survey, distributed to all members, yielded a total of 529 responses, 395 (74.7%) of which came from clinicians with experience with PSMD. Results: Parkinsonism (68%), hemiballismus/hemichorea (61%), tremor (58%), and dystonia (54%) were by far the most commonly endorsed presentation of PSMD, although this varied by region. Basal ganglia stroke (76% of responders), symptoms contralateral to stroke (75%), and a temporal relationship (59%) were considered important factors for the diagnosis of PSMD. Oral medication use depended on the phenomenology of the PSMD. Almost 50% of respondents considered deep brain stimulation and ablative surgeries as options for treatment. The lack of guidelines for the diagnosis and treatment was considered the most important gap to address. Conclusions: Regionally varying opinions and practices on PSMD highlight gaps in (and mistranslation of) epidemiologic and therapeutic knowledge. Multicenter registries and prospective community-based studies are needed for the creation of evidence-based guidelines to inform the diagnosis and treatment of patients with PSMD.
PB  - Elsevier
T2  - Journal of the Neurological Sciences
T2  - Journal of the Neurological Sciences
T1  - Current opinions and practices in post-stroke movement disorders: Survey of movement disorders society members
SP  - 122925
VL  - 458
DO  - 10.1016/j.jns.2024.122925
ER  - 

@article{
author = "Rodriguez-Porcel, Federico and Sarva, Harini and Joutsa, Juho and Falup-Pecurariu, Cristian and Wagle Shukla, Aparna and Mehanna, Raja and Śmiłowska, Katarzyna and Lanza, Giuseppe and Filipović, Saša and Shalash, Ali and Ferris, Margaret and Jankovic, Joseph and Espay, Alberto J. and Pandey, Sanjay",
year = "2024",
abstract = "Background: Post-stroke movement disorders (PSMD) encompass a wide array of presentations, which vary in mode of onset, phenomenology, response to treatment, and natural history. There are no evidence-based guidelines on the diagnosis and treatment of PSMD. Objectives: To survey current opinions and practices on the diagnosis and treatment of PSMD. Methods: A survey was developed by the PSMD Study Group, commissioned by the International Parkinson's and Movement Disorders Society (MDS). The survey, distributed to all members, yielded a total of 529 responses, 395 (74.7%) of which came from clinicians with experience with PSMD. Results: Parkinsonism (68%), hemiballismus/hemichorea (61%), tremor (58%), and dystonia (54%) were by far the most commonly endorsed presentation of PSMD, although this varied by region. Basal ganglia stroke (76% of responders), symptoms contralateral to stroke (75%), and a temporal relationship (59%) were considered important factors for the diagnosis of PSMD. Oral medication use depended on the phenomenology of the PSMD. Almost 50% of respondents considered deep brain stimulation and ablative surgeries as options for treatment. The lack of guidelines for the diagnosis and treatment was considered the most important gap to address. Conclusions: Regionally varying opinions and practices on PSMD highlight gaps in (and mistranslation of) epidemiologic and therapeutic knowledge. Multicenter registries and prospective community-based studies are needed for the creation of evidence-based guidelines to inform the diagnosis and treatment of patients with PSMD.",
publisher = "Elsevier",
journal = "Journal of the Neurological Sciences, Journal of the Neurological Sciences",
title = "Current opinions and practices in post-stroke movement disorders: Survey of movement disorders society members",
pages = "122925",
volume = "458",
doi = "10.1016/j.jns.2024.122925"
}

Rodriguez-Porcel, F., Sarva, H., Joutsa, J., Falup-Pecurariu, C., Wagle Shukla, A., Mehanna, R., Śmiłowska, K., Lanza, G., Filipović, S., Shalash, A., Ferris, M., Jankovic, J., Espay, A. J.,& Pandey, S.. (2024). Current opinions and practices in post-stroke movement disorders: Survey of movement disorders society members. in Journal of the Neurological Sciences
Elsevier., 458, 122925.
https://doi.org/10.1016/j.jns.2024.122925

Rodriguez-Porcel F, Sarva H, Joutsa J, Falup-Pecurariu C, Wagle Shukla A, Mehanna R, Śmiłowska K, Lanza G, Filipović S, Shalash A, Ferris M, Jankovic J, Espay AJ, Pandey S. Current opinions and practices in post-stroke movement disorders: Survey of movement disorders society members. in Journal of the Neurological Sciences. 2024;458:122925.
doi:10.1016/j.jns.2024.122925 .

Rodriguez-Porcel, Federico, Sarva, Harini, Joutsa, Juho, Falup-Pecurariu, Cristian, Wagle Shukla, Aparna, Mehanna, Raja, Śmiłowska, Katarzyna, Lanza, Giuseppe, Filipović, Saša, Shalash, Ali, Ferris, Margaret, Jankovic, Joseph, Espay, Alberto J., Pandey, Sanjay, "Current opinions and practices in post-stroke movement disorders: Survey of movement disorders society members" in Journal of the Neurological Sciences, 458 (2024):122925,
https://doi.org/10.1016/j.jns.2024.122925 . .

TY  - JOUR
AU  - Rasin, Puthiyavalappil
AU  - Basheer, Sabeel M.
AU  - Haribabu, Jebiti
AU  - Aneesrahman, K. N.
AU  - Manakkadan, Vipin
AU  - Vadakkedathu Palakkeezhillam, Vishnunarayanan Namboothiri
AU  - Bhuvanesh, Nattamai
AU  - Echeverria, Cesar
AU  - Santibanez, Juan F.
AU  - Sreekanth, Anandaram
PY  - 2024
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1463
AB  - A novel Coumarin-based 1,2-pyrazole, HCPyTSC is synthesised and characterized. The chemosensor has been shown to have efficient colourimetric and fluorescence sensing capabilities for the quick and selective detection of fluoride and copper ions. At 376 and 430 nm, the HCPyTSC exhibits selective sensing for Cu2+ and F− ions. By examining the natural bond orbital (NBO) analysis and the potential energy curve (PES) of the ground state for the function of the C–H bond, it has been determined from the theoretical study at hand that the deprotonation was taken from the ‘CH’ proton of the pyrazole ring. For F− and Cu2+, the HCPyTSC detection limits were 4.62 nM and 15.36 nM, respectively. Similarly, the binding constants (Kb) for F− and Cu2+ ions in acetonitrile medium were found to be 2.06 × 105 M−1 and 1.88 × 105 M−1. Chemosensor HCPyTSC with and without F− and Cu2+ ions have an emission and absorption response that can imitate a variety of logic gates, including the AND, XOR, and OR gates. Additionally, a paper-based sensor strip with the HCPyTSC was created for use in practical, flexible F− sensing applications. The paper-based sensor was more effective in detecting F− than other anions. The effectiveness of HCPyTSC for the selective detection of F− in living cells as well as its cell permeability were examined using live-cell imaging in T24 cells.
PB  - Elsevier
T2  - Heliyon
T1  - Host-guest interactions of coumarin-based 1,2-pyrazole using analytical and computational methods: Paper strip-based detection, live cell imaging, logic gates and keypad lock applications
IS  - 1
SP  - e24077
VL  - 10
DO  - 10.1016/j.heliyon.2024.e24077
ER  - 

@article{
author = "Rasin, Puthiyavalappil and Basheer, Sabeel M. and Haribabu, Jebiti and Aneesrahman, K. N. and Manakkadan, Vipin and Vadakkedathu Palakkeezhillam, Vishnunarayanan Namboothiri and Bhuvanesh, Nattamai and Echeverria, Cesar and Santibanez, Juan F. and Sreekanth, Anandaram",
year = "2024",
abstract = "A novel Coumarin-based 1,2-pyrazole, HCPyTSC is synthesised and characterized. The chemosensor has been shown to have efficient colourimetric and fluorescence sensing capabilities for the quick and selective detection of fluoride and copper ions. At 376 and 430 nm, the HCPyTSC exhibits selective sensing for Cu2+ and F− ions. By examining the natural bond orbital (NBO) analysis and the potential energy curve (PES) of the ground state for the function of the C–H bond, it has been determined from the theoretical study at hand that the deprotonation was taken from the ‘CH’ proton of the pyrazole ring. For F− and Cu2+, the HCPyTSC detection limits were 4.62 nM and 15.36 nM, respectively. Similarly, the binding constants (Kb) for F− and Cu2+ ions in acetonitrile medium were found to be 2.06 × 105 M−1 and 1.88 × 105 M−1. Chemosensor HCPyTSC with and without F− and Cu2+ ions have an emission and absorption response that can imitate a variety of logic gates, including the AND, XOR, and OR gates. Additionally, a paper-based sensor strip with the HCPyTSC was created for use in practical, flexible F− sensing applications. The paper-based sensor was more effective in detecting F− than other anions. The effectiveness of HCPyTSC for the selective detection of F− in living cells as well as its cell permeability were examined using live-cell imaging in T24 cells.",
publisher = "Elsevier",
journal = "Heliyon",
title = "Host-guest interactions of coumarin-based 1,2-pyrazole using analytical and computational methods: Paper strip-based detection, live cell imaging, logic gates and keypad lock applications",
number = "1",
pages = "e24077",
volume = "10",
doi = "10.1016/j.heliyon.2024.e24077"
}

Rasin, P., Basheer, S. M., Haribabu, J., Aneesrahman, K. N., Manakkadan, V., Vadakkedathu Palakkeezhillam, V. N., Bhuvanesh, N., Echeverria, C., Santibanez, J. F.,& Sreekanth, A.. (2024). Host-guest interactions of coumarin-based 1,2-pyrazole using analytical and computational methods: Paper strip-based detection, live cell imaging, logic gates and keypad lock applications. in Heliyon
Elsevier., 10(1), e24077.
https://doi.org/10.1016/j.heliyon.2024.e24077

Rasin P, Basheer SM, Haribabu J, Aneesrahman KN, Manakkadan V, Vadakkedathu Palakkeezhillam VN, Bhuvanesh N, Echeverria C, Santibanez JF, Sreekanth A. Host-guest interactions of coumarin-based 1,2-pyrazole using analytical and computational methods: Paper strip-based detection, live cell imaging, logic gates and keypad lock applications. in Heliyon. 2024;10(1):e24077.
doi:10.1016/j.heliyon.2024.e24077 .

Rasin, Puthiyavalappil, Basheer, Sabeel M., Haribabu, Jebiti, Aneesrahman, K. N., Manakkadan, Vipin, Vadakkedathu Palakkeezhillam, Vishnunarayanan Namboothiri, Bhuvanesh, Nattamai, Echeverria, Cesar, Santibanez, Juan F., Sreekanth, Anandaram, "Host-guest interactions of coumarin-based 1,2-pyrazole using analytical and computational methods: Paper strip-based detection, live cell imaging, logic gates and keypad lock applications" in Heliyon, 10, no. 1 (2024):e24077,
https://doi.org/10.1016/j.heliyon.2024.e24077 . .

TY  - JOUR
AU  - Gajdov, Vladimir
AU  - Jokić, Goran
AU  - Savić, Sara
AU  - Zekić, Marina
AU  - Blažić, Tanja
AU  - Rajković, Milica
AU  - Petrović, Tamaš
PY  - 2024
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1478
AB  - Introduction: This study aimed to investigate the prevalence and molecular characterization of Leptospira species in Belgrade, Serbia, an area where this disease is underexplored. Specifically, the study sought to employ molecular and multilocus sequence typing analyses to fill the gap in understanding the diversity and distribution of Leptospira species within the region.  Methods: A comprehensive molecular analysis was conducted on kidney samples obtained from Norway rats (Rattus norvegicus) in the urban environment. The study utilized molecular diagnostic techniques including real-time PCR targeting the lipL32 gene and performing sequence-based typing schemes utilizing adk, icdA, lipL32, lipL41, rrs2, and secY genes. These methodologies were applied to ascertain the presence and characterize different Leptospira species and serovars, respectively.  Results: The findings revealed the presence of two Leptospira species and three separate serovars in the Belgrade area. This study identified the presence of L. kirschneri serovar Mozdok in Serbia for the first time, a significant discovery previously undocumented in the region. This pioneering investigation sheds light on the molecular diversity and prevalence of Leptospira species in Serbia.  Discussion: The study underscores the importance of employing molecular typing methods to gain insights into the epidemiology and characterization of Leptospira species. These findings significantly contribute to both local and global perspectives on leptospirosis epidemiology, providing vital insights for the development of effective control strategies and interventions.  Summary: In our recent study, we explored the presence and performed molecular typing of the Leptospira species, the bacteria responsible for leptospirosis, in wild rats in Serbia. This was the first time such a study was conducted in the region. Leptospirosis is a serious disease that affects both animals and humans, often transmitted through contact with water contaminated by infected animals. Our focus was on understanding which types of Leptospira were present in these animals. Excitingly, we discovered a particular strain of Leptospira, known as L. kirshneri serovar Mozdok, for the first time in Serbia. This finding is significant because it sheds light on the presence and spread of different Leptospira serovars in Serbia. It also raises awareness about the potential health risks associated with this serovar, which was previously unknown in the area. Our work fits into a broader context of disease surveillance and public health. By identifying the types of Leptospira present in a specific region, we can better understand the risks to public health and take steps to prevent and control the spread of leptospirosis. This discovery is not just important for scientists studying infectious diseases; it has real implications for public health officials, veterinarians, and anyone concerned with preventing and treating leptospirosis. Our findings highlight the need for ongoing monitoring of Leptospira in wildlife and synanthropic fauna, to protect both animal and human health.
PB  - Frontiers Media SA
T2  - Frontiers in Microbiology
T1  - Genotyping of Leptospira spp. in wild rats leads to first time detection of L. kirshneri serovar Mozdok in Serbia
SP  - 1379021
VL  - 15
DO  - 10.3389/fmicb.2024.1379021
ER  - 

@article{
author = "Gajdov, Vladimir and Jokić, Goran and Savić, Sara and Zekić, Marina and Blažić, Tanja and Rajković, Milica and Petrović, Tamaš",
year = "2024",
abstract = "Introduction: This study aimed to investigate the prevalence and molecular characterization of Leptospira species in Belgrade, Serbia, an area where this disease is underexplored. Specifically, the study sought to employ molecular and multilocus sequence typing analyses to fill the gap in understanding the diversity and distribution of Leptospira species within the region.  Methods: A comprehensive molecular analysis was conducted on kidney samples obtained from Norway rats (Rattus norvegicus) in the urban environment. The study utilized molecular diagnostic techniques including real-time PCR targeting the lipL32 gene and performing sequence-based typing schemes utilizing adk, icdA, lipL32, lipL41, rrs2, and secY genes. These methodologies were applied to ascertain the presence and characterize different Leptospira species and serovars, respectively.  Results: The findings revealed the presence of two Leptospira species and three separate serovars in the Belgrade area. This study identified the presence of L. kirschneri serovar Mozdok in Serbia for the first time, a significant discovery previously undocumented in the region. This pioneering investigation sheds light on the molecular diversity and prevalence of Leptospira species in Serbia.  Discussion: The study underscores the importance of employing molecular typing methods to gain insights into the epidemiology and characterization of Leptospira species. These findings significantly contribute to both local and global perspectives on leptospirosis epidemiology, providing vital insights for the development of effective control strategies and interventions.  Summary: In our recent study, we explored the presence and performed molecular typing of the Leptospira species, the bacteria responsible for leptospirosis, in wild rats in Serbia. This was the first time such a study was conducted in the region. Leptospirosis is a serious disease that affects both animals and humans, often transmitted through contact with water contaminated by infected animals. Our focus was on understanding which types of Leptospira were present in these animals. Excitingly, we discovered a particular strain of Leptospira, known as L. kirshneri serovar Mozdok, for the first time in Serbia. This finding is significant because it sheds light on the presence and spread of different Leptospira serovars in Serbia. It also raises awareness about the potential health risks associated with this serovar, which was previously unknown in the area. Our work fits into a broader context of disease surveillance and public health. By identifying the types of Leptospira present in a specific region, we can better understand the risks to public health and take steps to prevent and control the spread of leptospirosis. This discovery is not just important for scientists studying infectious diseases; it has real implications for public health officials, veterinarians, and anyone concerned with preventing and treating leptospirosis. Our findings highlight the need for ongoing monitoring of Leptospira in wildlife and synanthropic fauna, to protect both animal and human health.",
publisher = "Frontiers Media SA",
journal = "Frontiers in Microbiology",
title = "Genotyping of Leptospira spp. in wild rats leads to first time detection of L. kirshneri serovar Mozdok in Serbia",
pages = "1379021",
volume = "15",
doi = "10.3389/fmicb.2024.1379021"
}

Gajdov, V., Jokić, G., Savić, S., Zekić, M., Blažić, T., Rajković, M.,& Petrović, T.. (2024). Genotyping of Leptospira spp. in wild rats leads to first time detection of L. kirshneri serovar Mozdok in Serbia. in Frontiers in Microbiology
Frontiers Media SA., 15, 1379021.
https://doi.org/10.3389/fmicb.2024.1379021

Gajdov V, Jokić G, Savić S, Zekić M, Blažić T, Rajković M, Petrović T. Genotyping of Leptospira spp. in wild rats leads to first time detection of L. kirshneri serovar Mozdok in Serbia. in Frontiers in Microbiology. 2024;15:1379021.
doi:10.3389/fmicb.2024.1379021 .

Gajdov, Vladimir, Jokić, Goran, Savić, Sara, Zekić, Marina, Blažić, Tanja, Rajković, Milica, Petrović, Tamaš, "Genotyping of Leptospira spp. in wild rats leads to first time detection of L. kirshneri serovar Mozdok in Serbia" in Frontiers in Microbiology, 15 (2024):1379021,
https://doi.org/10.3389/fmicb.2024.1379021 . .

TY  - JOUR
AU  - Simin, Stanislav
AU  - Tomanović, Snežana
AU  - Sukara, Ratko
AU  - Stefanov, Marijana
AU  - Savović, Milan
AU  - Gajić, Bojan
AU  - Lalošević, Vesna
PY  - 2024
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1477
AB  - The “beautiful viviparous fly”, Wohlfahrtia magnifica, may have a magnificent appearance due to its striking morphology; however, it is a potentially deadly agent of obligate traumatic myiasis in humans and animals, with a serious impact on welfare and economics. The fly is found across the Palearctic realm, including the Western Balkan region, with reports from former Yugoslavian countries from the first half of the 20th century. In this paper, a recent case of wohlfahrtiosis recorded in Northern Serbia is evidenced using morphological and molecular techniques. Larvae were collected from two adult sheep with severe hoof myiasis and two young sheep with genital and interdigital myiasis. Morphological identification was performed for adults bred from the infested vulva and third-stage larvae (L3) collected from the hoof wounds, supported with barcoding sequences of the COI gene obtained from larval pairs from the hoof wounds of older and the genitalia of younger sheep. W. magnifica was identified according to the appearance of male fly terminalia and the morphology of L3, which was confirmed after the comparison of representative sequences of the COI gene (deposited in GenBank™ under accession numbers MT027108–MT027114) to those available in GenBank™. This finding represents the first reported case of wohlfahrtiosis in the Western Balkans in 80 years, highlighting the need to re-inform relevant stakeholders to achieve adequate disease control.
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Microorganisms
T1  - Long Time No Hear, Magnificent Wohlfahrtia! Morphological and Molecular Evidence of Almost Forgotten Flesh Fly in Serbia and Western Balkans
IS  - 2
SP  - 233
VL  - 12
DO  - 10.3390/microorganisms12020233
ER  - 

@article{
author = "Simin, Stanislav and Tomanović, Snežana and Sukara, Ratko and Stefanov, Marijana and Savović, Milan and Gajić, Bojan and Lalošević, Vesna",
year = "2024",
abstract = "The “beautiful viviparous fly”, Wohlfahrtia magnifica, may have a magnificent appearance due to its striking morphology; however, it is a potentially deadly agent of obligate traumatic myiasis in humans and animals, with a serious impact on welfare and economics. The fly is found across the Palearctic realm, including the Western Balkan region, with reports from former Yugoslavian countries from the first half of the 20th century. In this paper, a recent case of wohlfahrtiosis recorded in Northern Serbia is evidenced using morphological and molecular techniques. Larvae were collected from two adult sheep with severe hoof myiasis and two young sheep with genital and interdigital myiasis. Morphological identification was performed for adults bred from the infested vulva and third-stage larvae (L3) collected from the hoof wounds, supported with barcoding sequences of the COI gene obtained from larval pairs from the hoof wounds of older and the genitalia of younger sheep. W. magnifica was identified according to the appearance of male fly terminalia and the morphology of L3, which was confirmed after the comparison of representative sequences of the COI gene (deposited in GenBank™ under accession numbers MT027108–MT027114) to those available in GenBank™. This finding represents the first reported case of wohlfahrtiosis in the Western Balkans in 80 years, highlighting the need to re-inform relevant stakeholders to achieve adequate disease control.",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Microorganisms",
title = "Long Time No Hear, Magnificent Wohlfahrtia! Morphological and Molecular Evidence of Almost Forgotten Flesh Fly in Serbia and Western Balkans",
number = "2",
pages = "233",
volume = "12",
doi = "10.3390/microorganisms12020233"
}

Simin, S., Tomanović, S., Sukara, R., Stefanov, M., Savović, M., Gajić, B.,& Lalošević, V.. (2024). Long Time No Hear, Magnificent Wohlfahrtia! Morphological and Molecular Evidence of Almost Forgotten Flesh Fly in Serbia and Western Balkans. in Microorganisms
Multidisciplinary Digital Publishing Institute (MDPI)., 12(2), 233.
https://doi.org/10.3390/microorganisms12020233

Simin S, Tomanović S, Sukara R, Stefanov M, Savović M, Gajić B, Lalošević V. Long Time No Hear, Magnificent Wohlfahrtia! Morphological and Molecular Evidence of Almost Forgotten Flesh Fly in Serbia and Western Balkans. in Microorganisms. 2024;12(2):233.
doi:10.3390/microorganisms12020233 .

Simin, Stanislav, Tomanović, Snežana, Sukara, Ratko, Stefanov, Marijana, Savović, Milan, Gajić, Bojan, Lalošević, Vesna, "Long Time No Hear, Magnificent Wohlfahrtia! Morphological and Molecular Evidence of Almost Forgotten Flesh Fly in Serbia and Western Balkans" in Microorganisms, 12, no. 2 (2024):233,
https://doi.org/10.3390/microorganisms12020233 . .

TY  - JOUR
AU  - Kapo, Naida
AU  - Zuber Bogdanović, Ivana
AU  - Gagović, Ema
AU  - Žekić, Marina
AU  - Veinović, Gorana
AU  - Sukara, Ratko
AU  - Mihaljica, Darko
AU  - Adžić, Bojan
AU  - Kadriaj, Përparim
AU  - Cvetkovikj, Aleksandar
AU  - Đađovski, Igor
AU  - Potkonjak, Aleksandar
AU  - Velo, Enkelejda
AU  - Savić, Sara
AU  - Tomanović, Snežana
AU  - Omeragić, Jasmin
AU  - Beck, Relja
AU  - Hodžić, Adnan
PY  - 2024
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1461
AB  - Ixodid ticks are distributed across all countries of the Western Balkans, with a high diversity of species. Many of these species serve as vectors of pathogens of veterinary and medical importance. Given the scattered data from Western Balkan countries, we have conducted a comprehensive review of available literature, including some historical data, with the aim to compile information about all recorded tick species and associated zoonotic pathogens in this region. Based on the collected data, the tick fauna of the Western Balkans encompasses 32 tick species belonging to five genera: Ixodes, Haemaphysalis, Dermacentor, Rhipicephalus and Hyalomma. A range of pathogens responsible for human diseases has also been documented, including viruses, bacteria and parasites. In this review, we emphasize the necessity for integrated surveillance and reporting, urging authorities to foster research by providing financial support. Additionally, international and interdisciplinary collaborations should be encouraged that include the exchange of expertise, experiences and resources. The present collaborative effort can effectively address gaps in our knowledge of ticks and tick-borne diseases.
PB  - Springer Nature
T2  - Parasites & Vectors
T2  - Parasites & VectorsParasites & Vectors
T1  - Ixodid ticks and zoonotic tick-borne pathogens of the Western Balkans
IS  - 1
SP  - 45
VL  - 17
DO  - 10.1186/s13071-023-06116-1
ER  - 

@article{
author = "Kapo, Naida and Zuber Bogdanović, Ivana and Gagović, Ema and Žekić, Marina and Veinović, Gorana and Sukara, Ratko and Mihaljica, Darko and Adžić, Bojan and Kadriaj, Përparim and Cvetkovikj, Aleksandar and Đađovski, Igor and Potkonjak, Aleksandar and Velo, Enkelejda and Savić, Sara and Tomanović, Snežana and Omeragić, Jasmin and Beck, Relja and Hodžić, Adnan",
year = "2024",
abstract = "Ixodid ticks are distributed across all countries of the Western Balkans, with a high diversity of species. Many of these species serve as vectors of pathogens of veterinary and medical importance. Given the scattered data from Western Balkan countries, we have conducted a comprehensive review of available literature, including some historical data, with the aim to compile information about all recorded tick species and associated zoonotic pathogens in this region. Based on the collected data, the tick fauna of the Western Balkans encompasses 32 tick species belonging to five genera: Ixodes, Haemaphysalis, Dermacentor, Rhipicephalus and Hyalomma. A range of pathogens responsible for human diseases has also been documented, including viruses, bacteria and parasites. In this review, we emphasize the necessity for integrated surveillance and reporting, urging authorities to foster research by providing financial support. Additionally, international and interdisciplinary collaborations should be encouraged that include the exchange of expertise, experiences and resources. The present collaborative effort can effectively address gaps in our knowledge of ticks and tick-borne diseases.",
publisher = "Springer Nature",
journal = "Parasites & Vectors, Parasites & VectorsParasites & Vectors",
title = "Ixodid ticks and zoonotic tick-borne pathogens of the Western Balkans",
number = "1",
pages = "45",
volume = "17",
doi = "10.1186/s13071-023-06116-1"
}

Kapo, N., Zuber Bogdanović, I., Gagović, E., Žekić, M., Veinović, G., Sukara, R., Mihaljica, D., Adžić, B., Kadriaj, P., Cvetkovikj, A., Đađovski, I., Potkonjak, A., Velo, E., Savić, S., Tomanović, S., Omeragić, J., Beck, R.,& Hodžić, A.. (2024). Ixodid ticks and zoonotic tick-borne pathogens of the Western Balkans. in Parasites & Vectors
Springer Nature., 17(1), 45.
https://doi.org/10.1186/s13071-023-06116-1

Kapo N, Zuber Bogdanović I, Gagović E, Žekić M, Veinović G, Sukara R, Mihaljica D, Adžić B, Kadriaj P, Cvetkovikj A, Đađovski I, Potkonjak A, Velo E, Savić S, Tomanović S, Omeragić J, Beck R, Hodžić A. Ixodid ticks and zoonotic tick-borne pathogens of the Western Balkans. in Parasites & Vectors. 2024;17(1):45.
doi:10.1186/s13071-023-06116-1 .

Kapo, Naida, Zuber Bogdanović, Ivana, Gagović, Ema, Žekić, Marina, Veinović, Gorana, Sukara, Ratko, Mihaljica, Darko, Adžić, Bojan, Kadriaj, Përparim, Cvetkovikj, Aleksandar, Đađovski, Igor, Potkonjak, Aleksandar, Velo, Enkelejda, Savić, Sara, Tomanović, Snežana, Omeragić, Jasmin, Beck, Relja, Hodžić, Adnan, "Ixodid ticks and zoonotic tick-borne pathogens of the Western Balkans" in Parasites & Vectors, 17, no. 1 (2024):45,
https://doi.org/10.1186/s13071-023-06116-1 . .

TY  - JOUR
AU  - Ćirković, Valentina
AU  - Veinović, Gorana
AU  - Stanković, Daliborka
AU  - Mihaljica, Darko
AU  - Sukara, Ratko
AU  - Tomanović, Snežana
PY  - 2024
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1465
AB  - Background: Borrelia lusitaniae is a species within the complex Borrelia burgdorferi sensu lato, associated with lizards as reservoirs and Ixodes ricinus as its main vector. Borrelia lusitaniae is predominantly distributed in Central and Southeast Europe, and in countries of the Mediterranean basin, such as Portugal, Morocco, Tunisia, and Italy where this spirochete appears to infect vector ticks more frequently than other genospecies. Evolution of this zoonotic tick-borne microparasite is shaped by different environmental factors. Comprehensive phylogenetic analysis may give insight into how B. lusitaniae spreads to new geographic locations.  Aim: We applied Bayesian statistical methods to B. lusitaniae multilocus sequence typing (MLST) data to study the migration routes of B. lusitaniae and its potential for further spread.  Results: The discrete phylogeographic analysis placed origins of B. lusitaniae in Southeast Europe and identified at least two introductions of B. lusitaniae from Europe to North Africa. Estimated effective reproductive potential (Re), as a key indicator for a pathogen spread, suggested potential for further spread.  Conclusion: The results of this study can provide beneficial information about the potential for further spread of B. lusitaniae in Europe and North Africa and estimation of necessity for the development of strategies to monitor and control Lyme borreliosis.
PB  - Frontiers Media SA
T2  - Frontiers in Microbiology
T2  - Frontiers in Microbiology
T1  - Evolutionary dynamics and geographical dispersal of Borrelia lusitaniae
SP  - 1330914
VL  - 15
DO  - 10.3389/fmicb.2024.1330914
ER  - 

@article{
author = "Ćirković, Valentina and Veinović, Gorana and Stanković, Daliborka and Mihaljica, Darko and Sukara, Ratko and Tomanović, Snežana",
year = "2024",
abstract = "Background: Borrelia lusitaniae is a species within the complex Borrelia burgdorferi sensu lato, associated with lizards as reservoirs and Ixodes ricinus as its main vector. Borrelia lusitaniae is predominantly distributed in Central and Southeast Europe, and in countries of the Mediterranean basin, such as Portugal, Morocco, Tunisia, and Italy where this spirochete appears to infect vector ticks more frequently than other genospecies. Evolution of this zoonotic tick-borne microparasite is shaped by different environmental factors. Comprehensive phylogenetic analysis may give insight into how B. lusitaniae spreads to new geographic locations.  Aim: We applied Bayesian statistical methods to B. lusitaniae multilocus sequence typing (MLST) data to study the migration routes of B. lusitaniae and its potential for further spread.  Results: The discrete phylogeographic analysis placed origins of B. lusitaniae in Southeast Europe and identified at least two introductions of B. lusitaniae from Europe to North Africa. Estimated effective reproductive potential (Re), as a key indicator for a pathogen spread, suggested potential for further spread.  Conclusion: The results of this study can provide beneficial information about the potential for further spread of B. lusitaniae in Europe and North Africa and estimation of necessity for the development of strategies to monitor and control Lyme borreliosis.",
publisher = "Frontiers Media SA",
journal = "Frontiers in Microbiology, Frontiers in Microbiology",
title = "Evolutionary dynamics and geographical dispersal of Borrelia lusitaniae",
pages = "1330914",
volume = "15",
doi = "10.3389/fmicb.2024.1330914"
}

Ćirković, V., Veinović, G., Stanković, D., Mihaljica, D., Sukara, R.,& Tomanović, S.. (2024). Evolutionary dynamics and geographical dispersal of Borrelia lusitaniae. in Frontiers in Microbiology
Frontiers Media SA., 15, 1330914.
https://doi.org/10.3389/fmicb.2024.1330914

Ćirković V, Veinović G, Stanković D, Mihaljica D, Sukara R, Tomanović S. Evolutionary dynamics and geographical dispersal of Borrelia lusitaniae. in Frontiers in Microbiology. 2024;15:1330914.
doi:10.3389/fmicb.2024.1330914 .

Ćirković, Valentina, Veinović, Gorana, Stanković, Daliborka, Mihaljica, Darko, Sukara, Ratko, Tomanović, Snežana, "Evolutionary dynamics and geographical dispersal of Borrelia lusitaniae" in Frontiers in Microbiology, 15 (2024):1330914,
https://doi.org/10.3389/fmicb.2024.1330914 . .

TY  - JOUR
AU  - Latas, Milan
AU  - Stefanovski, Branko
AU  - Mihaljević-Peleš, Alma
AU  - Serdarević, Amra Memić
AU  - Pajević, Izet
AU  - Radulović, Nera Zivlak
AU  - Radulović, Sabina
AU  - Đukić, Bojana
AU  - Korugić, Vasilije
AU  - Jovandić, Željko
PY  - 2024
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1466
AB  - Introduction: This paper aims to examine the frequency and significance of diagnostic comorbidity of psychiatric disorders and somatic diseases in a sample of patients with depression as well as present current psychopharmacological treatment of the patients in the sample. Methods The subjects in this study sample were 489 patients from the four Western Balkan countries with current primary diagnosis of major depression according to ICD 10. Comorbid psychiatric disorders and non-psychiatric illnesses were noted according to ICD 10 criteria during the diagnostic interview and analysed later. Additionally, the pharmacological treatment (existing and newly introduced) for each patient was noted and analysed later. Results At least one comorbid psychiatric disorder was present in 72.5% of patients. The most frequent were anxiety disorders (53.6%), specifically generalized anxiety disorder (20.2%); non-organic sleep disorders (50.7%), specifically insomnia (48.4%); and sexual dysfunctions (21.4%), specifically lack of sexual desire (20.2%). Comorbidity with any non-psychiatric illness was present in 80.3% of patients. The most frequent were circulatory system diseases (55.9%), specifically hypertension (45.9%); endocrine, nutritional and metabolic disorders (51.3%), specifically hyperlipidaemia (24.0%); and other non-psychiatric disorders (60.7%), specifically low back pain (22.7%). All patients received pharmacological treatment with different medications. Most patients received monotherapy or combination therapy of antidepressants, anxiolytics, antipsychotics and antiepileptics. The most frequently used antidepressants were escitalopram, sertraline, and duloxetine. The most frequently used anxiolytics were alprazolam and diazepam, the most used antiepileptic was pregabalin, and the most used antipsychotics were olanzapine, quetiapine, and aripiprazole. Conclusion The results of the study confirm the results of previous research studies about the high prevalence of psychiatric and non-psychiatric comorbidities in patients with depression that were conducted in the past. It would be important if future studies could prove the importance of those comorbidities on clinical severity, choice of treatment, and its outcome in patients with depression.
PB  - PLOS
T2  - PLOS ONE
T1  - Diagnostic psychiatric and somatic comorbidity in patients with depression in the Western Balkan countries
IS  - 1
SP  - e0295754
VL  - 19
DO  - 10.1371/journal.pone.0295754
ER  - 

@article{
author = "Latas, Milan and Stefanovski, Branko and Mihaljević-Peleš, Alma and Serdarević, Amra Memić and Pajević, Izet and Radulović, Nera Zivlak and Radulović, Sabina and Đukić, Bojana and Korugić, Vasilije and Jovandić, Željko",
year = "2024",
abstract = "Introduction: This paper aims to examine the frequency and significance of diagnostic comorbidity of psychiatric disorders and somatic diseases in a sample of patients with depression as well as present current psychopharmacological treatment of the patients in the sample. Methods The subjects in this study sample were 489 patients from the four Western Balkan countries with current primary diagnosis of major depression according to ICD 10. Comorbid psychiatric disorders and non-psychiatric illnesses were noted according to ICD 10 criteria during the diagnostic interview and analysed later. Additionally, the pharmacological treatment (existing and newly introduced) for each patient was noted and analysed later. Results At least one comorbid psychiatric disorder was present in 72.5% of patients. The most frequent were anxiety disorders (53.6%), specifically generalized anxiety disorder (20.2%); non-organic sleep disorders (50.7%), specifically insomnia (48.4%); and sexual dysfunctions (21.4%), specifically lack of sexual desire (20.2%). Comorbidity with any non-psychiatric illness was present in 80.3% of patients. The most frequent were circulatory system diseases (55.9%), specifically hypertension (45.9%); endocrine, nutritional and metabolic disorders (51.3%), specifically hyperlipidaemia (24.0%); and other non-psychiatric disorders (60.7%), specifically low back pain (22.7%). All patients received pharmacological treatment with different medications. Most patients received monotherapy or combination therapy of antidepressants, anxiolytics, antipsychotics and antiepileptics. The most frequently used antidepressants were escitalopram, sertraline, and duloxetine. The most frequently used anxiolytics were alprazolam and diazepam, the most used antiepileptic was pregabalin, and the most used antipsychotics were olanzapine, quetiapine, and aripiprazole. Conclusion The results of the study confirm the results of previous research studies about the high prevalence of psychiatric and non-psychiatric comorbidities in patients with depression that were conducted in the past. It would be important if future studies could prove the importance of those comorbidities on clinical severity, choice of treatment, and its outcome in patients with depression.",
publisher = "PLOS",
journal = "PLOS ONE",
title = "Diagnostic psychiatric and somatic comorbidity in patients with depression in the Western Balkan countries",
number = "1",
pages = "e0295754",
volume = "19",
doi = "10.1371/journal.pone.0295754"
}

Latas, M., Stefanovski, B., Mihaljević-Peleš, A., Serdarević, A. M., Pajević, I., Radulović, N. Z., Radulović, S., Đukić, B., Korugić, V.,& Jovandić, Ž.. (2024). Diagnostic psychiatric and somatic comorbidity in patients with depression in the Western Balkan countries. in PLOS ONE
PLOS., 19(1), e0295754.
https://doi.org/10.1371/journal.pone.0295754

Latas M, Stefanovski B, Mihaljević-Peleš A, Serdarević AM, Pajević I, Radulović NZ, Radulović S, Đukić B, Korugić V, Jovandić Ž. Diagnostic psychiatric and somatic comorbidity in patients with depression in the Western Balkan countries. in PLOS ONE. 2024;19(1):e0295754.
doi:10.1371/journal.pone.0295754 .

Latas, Milan, Stefanovski, Branko, Mihaljević-Peleš, Alma, Serdarević, Amra Memić, Pajević, Izet, Radulović, Nera Zivlak, Radulović, Sabina, Đukić, Bojana, Korugić, Vasilije, Jovandić, Željko, "Diagnostic psychiatric and somatic comorbidity in patients with depression in the Western Balkan countries" in PLOS ONE, 19, no. 1 (2024):e0295754,
https://doi.org/10.1371/journal.pone.0295754 . .

TY  - JOUR
AU  - Haribabu, Jebiti
AU  - Arulkumar, Rasu
AU  - Mahendiran, Dharmasivam
AU  - Jeyalakshmi, Kumaramangalam
AU  - Swaminathan, Srividya
AU  - Venuvanalingam, Ponnambalam
AU  - Bhuvanesh, Nattamai
AU  - Santibanez, Juan F.
AU  - Karvembu, Ramasamy
PY  - 2024
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1475
AB  - Ru(II)-benzene complexes (P1 and P2) were synthesized using a thiosemicarbazone ligand (L1) in two different coordination modes, monodentate S and bidentate N,S, through carefully adjusted reaction conditions. Comprehensive characterization of the complexes was achieved through single crystal X-ray diffraction, revealing a piano-stool geometry around the Ru(II) ion. To evaluate the binding capabilities of the complexes towards CT DNA and BSA, UV–Vis and/or hydrodynamic methods were utilized. Docking studies further validated the intercalative binding mode with DNA, in agreement with the experimental findings, and identified specific BSA amino acids involved in the binding interactions. Based on the results of binding studies, cytotoxicity of the ligand and complexes was appraised in various cancer and normal cell lines alongside the commercial pharmaceutics. Complexes P1 and P2 displayed a promising activity against MDA-MB-231 [IC50 = 5.11 (P1) and 3.48 μM (P2)] and PANC-1 [IC50 = 7.20 (P1) and 4.85 μM (P2)] cancer cells; with the bidentate system (P2) exhibiting a higher activity than its monodentate congener P1, although both of them showed superior activity than the reference drugs. Various bioassays including Western blot analysis revealed the mode of cell death to be apoptosis, which was further concluded to be via the ROS-mediated mitochondrial signaling pathway.
PB  - Elsevier
T2  - Inorganica Chimica Acta
T1  - Effect of coordination mode of thiosemicarbazone on the biological activities of its Ru(II)-benzene complexes: Biomolecular interactions and anticancer activity via ROS-mediated mitochondrial apoptosis
SP  - 121973
VL  - 565
DO  - 10.1016/j.ica.2024.121973
ER  - 

@article{
author = "Haribabu, Jebiti and Arulkumar, Rasu and Mahendiran, Dharmasivam and Jeyalakshmi, Kumaramangalam and Swaminathan, Srividya and Venuvanalingam, Ponnambalam and Bhuvanesh, Nattamai and Santibanez, Juan F. and Karvembu, Ramasamy",
year = "2024",
abstract = "Ru(II)-benzene complexes (P1 and P2) were synthesized using a thiosemicarbazone ligand (L1) in two different coordination modes, monodentate S and bidentate N,S, through carefully adjusted reaction conditions. Comprehensive characterization of the complexes was achieved through single crystal X-ray diffraction, revealing a piano-stool geometry around the Ru(II) ion. To evaluate the binding capabilities of the complexes towards CT DNA and BSA, UV–Vis and/or hydrodynamic methods were utilized. Docking studies further validated the intercalative binding mode with DNA, in agreement with the experimental findings, and identified specific BSA amino acids involved in the binding interactions. Based on the results of binding studies, cytotoxicity of the ligand and complexes was appraised in various cancer and normal cell lines alongside the commercial pharmaceutics. Complexes P1 and P2 displayed a promising activity against MDA-MB-231 [IC50 = 5.11 (P1) and 3.48 μM (P2)] and PANC-1 [IC50 = 7.20 (P1) and 4.85 μM (P2)] cancer cells; with the bidentate system (P2) exhibiting a higher activity than its monodentate congener P1, although both of them showed superior activity than the reference drugs. Various bioassays including Western blot analysis revealed the mode of cell death to be apoptosis, which was further concluded to be via the ROS-mediated mitochondrial signaling pathway.",
publisher = "Elsevier",
journal = "Inorganica Chimica Acta",
title = "Effect of coordination mode of thiosemicarbazone on the biological activities of its Ru(II)-benzene complexes: Biomolecular interactions and anticancer activity via ROS-mediated mitochondrial apoptosis",
pages = "121973",
volume = "565",
doi = "10.1016/j.ica.2024.121973"
}

Haribabu, J., Arulkumar, R., Mahendiran, D., Jeyalakshmi, K., Swaminathan, S., Venuvanalingam, P., Bhuvanesh, N., Santibanez, J. F.,& Karvembu, R.. (2024). Effect of coordination mode of thiosemicarbazone on the biological activities of its Ru(II)-benzene complexes: Biomolecular interactions and anticancer activity via ROS-mediated mitochondrial apoptosis. in Inorganica Chimica Acta
Elsevier., 565, 121973.
https://doi.org/10.1016/j.ica.2024.121973

Haribabu J, Arulkumar R, Mahendiran D, Jeyalakshmi K, Swaminathan S, Venuvanalingam P, Bhuvanesh N, Santibanez JF, Karvembu R. Effect of coordination mode of thiosemicarbazone on the biological activities of its Ru(II)-benzene complexes: Biomolecular interactions and anticancer activity via ROS-mediated mitochondrial apoptosis. in Inorganica Chimica Acta. 2024;565:121973.
doi:10.1016/j.ica.2024.121973 .

Haribabu, Jebiti, Arulkumar, Rasu, Mahendiran, Dharmasivam, Jeyalakshmi, Kumaramangalam, Swaminathan, Srividya, Venuvanalingam, Ponnambalam, Bhuvanesh, Nattamai, Santibanez, Juan F., Karvembu, Ramasamy, "Effect of coordination mode of thiosemicarbazone on the biological activities of its Ru(II)-benzene complexes: Biomolecular interactions and anticancer activity via ROS-mediated mitochondrial apoptosis" in Inorganica Chimica Acta, 565 (2024):121973,
https://doi.org/10.1016/j.ica.2024.121973 . .

TY  - JOUR
AU  - Đukić, Tamara
AU  - Drvenica, Ivana
AU  - Kovačić, Marijana
AU  - Milanović, Slađan
AU  - Majerič, Dragana
AU  - Šefik-Bukilica, Mirjana
AU  - Miletić, Maja
AU  - Bugarski, Branko
AU  - Ilić, Vesna
PY  - 2024
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1474
AB  - The function of immune complexes in rheumatoid arthritis (RA) is related to their composition and size. Using dynamic light scattering (DLS), we investigated the link between the RA circulating immune complex (CIC) particles’ size and the CIC immunoglobulin level. In this study, 30 RA patients and 30 healthy individuals were included. IgA, IgG, and IgM were found in all analyzed CICs, but more IgA and IgG were found in RA than in control CICs. In both control and RA CICs, DLS detected 50 particles that differed in size and clustered around two size groups: with a 7.5–164 nm radius and with a 342–1718 nm radius. An increased level of IgA in RA CICs, compared to control ones, was associated with more than 50% of CIC particles. In RA, compared to the control, a higher number of CICs with 28.2 nm, 531 nm, 712 nm, and 1718 nm particles and a lower number of CICs with 78.8 nm particles were detected. This particle distribution pattern did not reflect the changes in the CIC immunoglobulin level. Thus, RA elevated CIC IgA was linked with all these particles (except the 1718 nm particle), the IgM increase was linked with 43.8 nm and 712 nm particles, and the IgG increase was linked with the 712 nm particle only. This study provides the very first data on the association between CIC particles’ size, CIC immunoglobulin level, and RA. It opens the possibility that the size of CICs determined by DLS can be used as a criterion in RA diagnosis or monitoring after a large-scale study confirmation.
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
T2  - International Journal of Molecular Sciences
T1  - Exploring the Link between Hydrodynamic Size and Immunoglobulins of Circulating Immune Complexes in Rheumatoid Arthritis Patients
IS  - 6
SP  - 3138
VL  - 25
DO  - 10.3390/ijms25063138
ER  - 

@article{
author = "Đukić, Tamara and Drvenica, Ivana and Kovačić, Marijana and Milanović, Slađan and Majerič, Dragana and Šefik-Bukilica, Mirjana and Miletić, Maja and Bugarski, Branko and Ilić, Vesna",
year = "2024",
abstract = "The function of immune complexes in rheumatoid arthritis (RA) is related to their composition and size. Using dynamic light scattering (DLS), we investigated the link between the RA circulating immune complex (CIC) particles’ size and the CIC immunoglobulin level. In this study, 30 RA patients and 30 healthy individuals were included. IgA, IgG, and IgM were found in all analyzed CICs, but more IgA and IgG were found in RA than in control CICs. In both control and RA CICs, DLS detected 50 particles that differed in size and clustered around two size groups: with a 7.5–164 nm radius and with a 342–1718 nm radius. An increased level of IgA in RA CICs, compared to control ones, was associated with more than 50% of CIC particles. In RA, compared to the control, a higher number of CICs with 28.2 nm, 531 nm, 712 nm, and 1718 nm particles and a lower number of CICs with 78.8 nm particles were detected. This particle distribution pattern did not reflect the changes in the CIC immunoglobulin level. Thus, RA elevated CIC IgA was linked with all these particles (except the 1718 nm particle), the IgM increase was linked with 43.8 nm and 712 nm particles, and the IgG increase was linked with the 712 nm particle only. This study provides the very first data on the association between CIC particles’ size, CIC immunoglobulin level, and RA. It opens the possibility that the size of CICs determined by DLS can be used as a criterion in RA diagnosis or monitoring after a large-scale study confirmation.",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "International Journal of Molecular Sciences",
title = "Exploring the Link between Hydrodynamic Size and Immunoglobulins of Circulating Immune Complexes in Rheumatoid Arthritis Patients",
number = "6",
pages = "3138",
volume = "25",
doi = "10.3390/ijms25063138"
}

Đukić, T., Drvenica, I., Kovačić, M., Milanović, S., Majerič, D., Šefik-Bukilica, M., Miletić, M., Bugarski, B.,& Ilić, V.. (2024). Exploring the Link between Hydrodynamic Size and Immunoglobulins of Circulating Immune Complexes in Rheumatoid Arthritis Patients. in International Journal of Molecular Sciences
Multidisciplinary Digital Publishing Institute (MDPI)., 25(6), 3138.
https://doi.org/10.3390/ijms25063138

Đukić T, Drvenica I, Kovačić M, Milanović S, Majerič D, Šefik-Bukilica M, Miletić M, Bugarski B, Ilić V. Exploring the Link between Hydrodynamic Size and Immunoglobulins of Circulating Immune Complexes in Rheumatoid Arthritis Patients. in International Journal of Molecular Sciences. 2024;25(6):3138.
doi:10.3390/ijms25063138 .

Đukić, Tamara, Drvenica, Ivana, Kovačić, Marijana, Milanović, Slađan, Majerič, Dragana, Šefik-Bukilica, Mirjana, Miletić, Maja, Bugarski, Branko, Ilić, Vesna, "Exploring the Link between Hydrodynamic Size and Immunoglobulins of Circulating Immune Complexes in Rheumatoid Arthritis Patients" in International Journal of Molecular Sciences, 25, no. 6 (2024):3138,
https://doi.org/10.3390/ijms25063138 . .

TY  - JOUR
AU  - Lijeskić, Olivera
AU  - Bauman, Neda
AU  - Marković, Miloš
AU  - Srbljanović, Jelena
AU  - Bobić, Branko
AU  - Zlatković, Đorđe
AU  - Štajner, Tijana
PY  - 2024
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1462
AB  - The aim of this study was to evaluate immunogenicity and longevity of the humoral immune response within six months after the homologous (BNT162b2/BNT162b2) or heterologous (BBIBP-CorV/BNT162b2) third dose, and to assess breakthrough infections among vaccinees during the Omicron wave in Serbia. Serum samples were analyzed at four timepoints: five months after the primary series; three weeks, three months, and six months after the boost. IgG antibodies against the receptor-binding domain of the spike protein were detected using enzyme-linked fluorescence assay. Both homologous (n = 55) and heterologous group (n = 36) showed a highly significant increase in antibody concentrations (p < 0.001) three weeks after the boost. A moderate inverse correlation between the age of recipients and the antibody levels at three weeks post-boost was observed in the homologous group (p = 0.02, r = −0.37), while the same correlation was not significant for heterologous group (p = 0.55, r = −0.15). Heterologous group had significantly higher antibody concentrations than homologous group at three weeks (Median 851.4(IQR 766.6–894.1); 784.3(676.9–847.4); p = 0.03) and three months post-boost (766.6(534.8–798.9); 496.8(361.6–664.0); p < 0.001). However, a significant decline in antibody response over time was noted for both strategies. The overall incidence of breakthrough cases was estimated at 36.36% (20/55) for homologous, and 16.67% (6/36) for heterologous group, but none of them required hospitalization. Although observed incidence in the homologous group was more than double when compared to the heterologous group, this difference was not statistically significant, most likely due to the small sample size. In conclusion, waning immunity after inactivated vaccine can be recovered by BNT162b2 heterologous boost regardless of the age of recipients, and both boost strategies induced potent humoral immune response and protection against severe COVID-19 during the Omicron wave. However, as the observed incidence of breakthrough infections was higher in the homologous group, although non-significant, this finding could indicate an advantage of heterologous approach.
PB  - Elsevier
T2  - Vaccine
T2  - Vaccine
T1  - SARS-CoV-2 specific antibody response after an mRNA vaccine as the third dose: Homologous versus heterologous boost
EP  - 1672
IS  - 7
SP  - 1665
VL  - 42
DO  - 10.1016/j.vaccine.2024.01.085
ER  - 

@article{
author = "Lijeskić, Olivera and Bauman, Neda and Marković, Miloš and Srbljanović, Jelena and Bobić, Branko and Zlatković, Đorđe and Štajner, Tijana",
year = "2024",
abstract = "The aim of this study was to evaluate immunogenicity and longevity of the humoral immune response within six months after the homologous (BNT162b2/BNT162b2) or heterologous (BBIBP-CorV/BNT162b2) third dose, and to assess breakthrough infections among vaccinees during the Omicron wave in Serbia. Serum samples were analyzed at four timepoints: five months after the primary series; three weeks, three months, and six months after the boost. IgG antibodies against the receptor-binding domain of the spike protein were detected using enzyme-linked fluorescence assay. Both homologous (n = 55) and heterologous group (n = 36) showed a highly significant increase in antibody concentrations (p < 0.001) three weeks after the boost. A moderate inverse correlation between the age of recipients and the antibody levels at three weeks post-boost was observed in the homologous group (p = 0.02, r = −0.37), while the same correlation was not significant for heterologous group (p = 0.55, r = −0.15). Heterologous group had significantly higher antibody concentrations than homologous group at three weeks (Median 851.4(IQR 766.6–894.1); 784.3(676.9–847.4); p = 0.03) and three months post-boost (766.6(534.8–798.9); 496.8(361.6–664.0); p < 0.001). However, a significant decline in antibody response over time was noted for both strategies. The overall incidence of breakthrough cases was estimated at 36.36% (20/55) for homologous, and 16.67% (6/36) for heterologous group, but none of them required hospitalization. Although observed incidence in the homologous group was more than double when compared to the heterologous group, this difference was not statistically significant, most likely due to the small sample size. In conclusion, waning immunity after inactivated vaccine can be recovered by BNT162b2 heterologous boost regardless of the age of recipients, and both boost strategies induced potent humoral immune response and protection against severe COVID-19 during the Omicron wave. However, as the observed incidence of breakthrough infections was higher in the homologous group, although non-significant, this finding could indicate an advantage of heterologous approach.",
publisher = "Elsevier",
journal = "Vaccine, Vaccine",
title = "SARS-CoV-2 specific antibody response after an mRNA vaccine as the third dose: Homologous versus heterologous boost",
pages = "1672-1665",
number = "7",
volume = "42",
doi = "10.1016/j.vaccine.2024.01.085"
}

Lijeskić, O., Bauman, N., Marković, M., Srbljanović, J., Bobić, B., Zlatković, Đ.,& Štajner, T.. (2024). SARS-CoV-2 specific antibody response after an mRNA vaccine as the third dose: Homologous versus heterologous boost. in Vaccine
Elsevier., 42(7), 1665-1672.
https://doi.org/10.1016/j.vaccine.2024.01.085

Lijeskić O, Bauman N, Marković M, Srbljanović J, Bobić B, Zlatković Đ, Štajner T. SARS-CoV-2 specific antibody response after an mRNA vaccine as the third dose: Homologous versus heterologous boost. in Vaccine. 2024;42(7):1665-1672.
doi:10.1016/j.vaccine.2024.01.085 .

Lijeskić, Olivera, Bauman, Neda, Marković, Miloš, Srbljanović, Jelena, Bobić, Branko, Zlatković, Đorđe, Štajner, Tijana, "SARS-CoV-2 specific antibody response after an mRNA vaccine as the third dose: Homologous versus heterologous boost" in Vaccine, 42, no. 7 (2024):1665-1672,
https://doi.org/10.1016/j.vaccine.2024.01.085 . .

TY  - CONF
AU  - Ristić, Biljana
AU  - Trpkov, Đorđe
AU  - Drvenica, Ivana
AU  - Dojčilović, Radovan
AU  - Đukić, Tamara
AU  - Tošić, Dragana
AU  - Pajović, Jelena
AU  - Božanić, Dušan K.
AU  - Trivanović, Drenka
AU  - Matić, Tamara
AU  - Sredojević, Dušan
AU  - Ilić, Vesna
AU  - Đoković, Vladimir
PY  - 2024
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1471
AB  - Nitrogen-doped carbon quantum dots (N-CQDs) are promising next
generation nanomaterials for potential biomedical applications such as bioimaging, biosensing,
and drug/gene delivery. However, N-CQDs biocompatibility has not been extensively
investigated. Here, we report physico-chemical characteristics of newly synthetized N-CQDs
and their effects on red blood cells (RBC), by analyzing their hemolytic activity, impact on
RBC rheology/morphology, and oxidative stress induction. N-CQDs were prepared by
hydrothermal method using citric acid and urea as precursors. Structural analyses of as prepared
N-GQDs, observed by HRTEM/EDS, showed that the lateral dimensions of the particles are in
the 10 to 20 nm range, as well as that the carbon, oxygen, and nitrogen are present in the
nanosystem. Based on AFM measurements, the average height of N-CQDs was 3.9±0.08 Å.
Photoluminescence emission (PLE) spectrum demonstrated that N-CQDs exhibit stable and
strong fluorescence in green (520 nm) region, upon 410 nm excitation. FTIR spectroscopy
indicated vibrational bands, characteristic for carbon structures and primary amines (Ndoping).
N-CQDs were negatively charged with an average Zeta potential of -15.3
mV as confirmed by DLS. To investigate hemocompatibility of N-CQDs, the RBC, the most
abundant cells in blood, were treated with different concentration of N-CQDs (10-400 ug/ml)
for 2h. Obtained results showed that there was no hemolytic activity. Moreover, ektacytometry
analysis demonstrated that N-CQDs did not affect deformability of RBC. Fluorescent
microscopy analyses revealed that treatment with N-CQDs did not induce significant
morphological aberrant forms of RBC which was also confirmed by SEM analyses. Flow
cytometry confirmed only slight RBC morphological changes based on FSC/SSC analysis.
Furthermore, using ROS sensitive dye flow cytometry analyses suggested that N-CQDs did not
induce oxidative stress in RBC. Taken together, our findings highlighted that exposure of RBC
to N-CQDs only led to the attachment of N-CQDs on RBC membranes, but there is no other
evidence of their nanotoxicity. These findings suggested that N-CQDs synthetized from ecofriendly
precursors are potentially biocompatible and safe for biomedical application.
PB  - Belgrade : Institute of Physics
C3  - Book of Abstracts: 17th Photonics Workshop, (Conference), Kopaonik, March 10-14, 2024
T1  - Hemocompatibility evaluation of N-doped carbon quantum dots
EP  - 47
SP  - 47
UR  - https://hdl.handle.net/21.15107/rcub_rimi_1471
ER  - 

@conference{
author = "Ristić, Biljana and Trpkov, Đorđe and Drvenica, Ivana and Dojčilović, Radovan and Đukić, Tamara and Tošić, Dragana and Pajović, Jelena and Božanić, Dušan K. and Trivanović, Drenka and Matić, Tamara and Sredojević, Dušan and Ilić, Vesna and Đoković, Vladimir",
year = "2024",
abstract = "Nitrogen-doped carbon quantum dots (N-CQDs) are promising next
generation nanomaterials for potential biomedical applications such as bioimaging, biosensing,
and drug/gene delivery. However, N-CQDs biocompatibility has not been extensively
investigated. Here, we report physico-chemical characteristics of newly synthetized N-CQDs
and their effects on red blood cells (RBC), by analyzing their hemolytic activity, impact on
RBC rheology/morphology, and oxidative stress induction. N-CQDs were prepared by
hydrothermal method using citric acid and urea as precursors. Structural analyses of as prepared
N-GQDs, observed by HRTEM/EDS, showed that the lateral dimensions of the particles are in
the 10 to 20 nm range, as well as that the carbon, oxygen, and nitrogen are present in the
nanosystem. Based on AFM measurements, the average height of N-CQDs was 3.9±0.08 Å.
Photoluminescence emission (PLE) spectrum demonstrated that N-CQDs exhibit stable and
strong fluorescence in green (520 nm) region, upon 410 nm excitation. FTIR spectroscopy
indicated vibrational bands, characteristic for carbon structures and primary amines (Ndoping).
N-CQDs were negatively charged with an average Zeta potential of -15.3
mV as confirmed by DLS. To investigate hemocompatibility of N-CQDs, the RBC, the most
abundant cells in blood, were treated with different concentration of N-CQDs (10-400 ug/ml)
for 2h. Obtained results showed that there was no hemolytic activity. Moreover, ektacytometry
analysis demonstrated that N-CQDs did not affect deformability of RBC. Fluorescent
microscopy analyses revealed that treatment with N-CQDs did not induce significant
morphological aberrant forms of RBC which was also confirmed by SEM analyses. Flow
cytometry confirmed only slight RBC morphological changes based on FSC/SSC analysis.
Furthermore, using ROS sensitive dye flow cytometry analyses suggested that N-CQDs did not
induce oxidative stress in RBC. Taken together, our findings highlighted that exposure of RBC
to N-CQDs only led to the attachment of N-CQDs on RBC membranes, but there is no other
evidence of their nanotoxicity. These findings suggested that N-CQDs synthetized from ecofriendly
precursors are potentially biocompatible and safe for biomedical application.",
publisher = "Belgrade : Institute of Physics",
journal = "Book of Abstracts: 17th Photonics Workshop, (Conference), Kopaonik, March 10-14, 2024",
title = "Hemocompatibility evaluation of N-doped carbon quantum dots",
pages = "47-47",
url = "https://hdl.handle.net/21.15107/rcub_rimi_1471"
}

Ristić, B., Trpkov, Đ., Drvenica, I., Dojčilović, R., Đukić, T., Tošić, D., Pajović, J., Božanić, D. K., Trivanović, D., Matić, T., Sredojević, D., Ilić, V.,& Đoković, V.. (2024). Hemocompatibility evaluation of N-doped carbon quantum dots. in Book of Abstracts: 17th Photonics Workshop, (Conference), Kopaonik, March 10-14, 2024
Belgrade : Institute of Physics., 47-47.
https://hdl.handle.net/21.15107/rcub_rimi_1471

Ristić B, Trpkov Đ, Drvenica I, Dojčilović R, Đukić T, Tošić D, Pajović J, Božanić DK, Trivanović D, Matić T, Sredojević D, Ilić V, Đoković V. Hemocompatibility evaluation of N-doped carbon quantum dots. in Book of Abstracts: 17th Photonics Workshop, (Conference), Kopaonik, March 10-14, 2024. 2024;:47-47.
https://hdl.handle.net/21.15107/rcub_rimi_1471 .

Ristić, Biljana, Trpkov, Đorđe, Drvenica, Ivana, Dojčilović, Radovan, Đukić, Tamara, Tošić, Dragana, Pajović, Jelena, Božanić, Dušan K., Trivanović, Drenka, Matić, Tamara, Sredojević, Dušan, Ilić, Vesna, Đoković, Vladimir, "Hemocompatibility evaluation of N-doped carbon quantum dots" in Book of Abstracts: 17th Photonics Workshop, (Conference), Kopaonik, March 10-14, 2024 (2024):47-47,
https://hdl.handle.net/21.15107/rcub_rimi_1471 .

TY  - JOUR
AU  - Bauman, Neda
AU  - Srbljanović, Jelena
AU  - Čolović Čalovski, Ivana
AU  - Lijeskić, Olivera
AU  - Ćirković, Vladimir
AU  - Trajković, Jelena
AU  - Bobić, Branko
AU  - Ilić, Andjelija Ž
AU  - Štajner, Tijana
PY  - 2024
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1473
AB  - Toxoplasma gondii is an obligate intracellular parasite existing in three infectious life stages—tachyzoites, bradyzoites, and sporozoites. Rupture of tissue cysts and re-conversion of bradyzoites to tachyzoites leads to reactivated toxoplasmosis (RT) in an immunocompromised host. The aim of this study was to apply ImageJ software for analysis of T. gondii brain cysts obtained from a newly established in vivo model of RT. Mice chronically infected with T. gondii (BGD1 and BGD26 strains) were treated with cyclophosphamide and hydrocortisone (experimental group—EG) or left untreated as infection controls (ICs). RT in mice was confirmed by qPCR (PCR+); mice remaining chronically infected were PCR−. A total of 90 images of cysts were analyzed for fractal dimension (FD), lacunarity (L), diameter (D), circularity (C), and packing density (PD). Circularity was significantly higher in PCR+ compared to IC mice (p < 0.05 for BGD1, p < 0.001 for the BGD26 strain). A significant negative correlation between D and PD was observed only in IC for the BGD1 strain (ρ = −0.384, p = 0.048), while fractal parameters were stable. Significantly higher D, C, and PD and lower lacunarity, L, were noticed in the BGD1 compared to the more aggressive BGD26 strain. In conclusion, these results demonstrate the complexity of structural alterations of T. gondii cysts in an immunocompromised host and emphasize the application potential of ImageJ in the experimental models of toxoplasmosis.
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Fractal and Fractional
T2  - Fractal and Fractional
T1  - Structural Characterization of Toxoplasma gondii Brain Cysts in a Model of Reactivated Toxoplasmosis Using Computational Image Analysis
IS  - 3
SP  - 175
VL  - 8
DO  - 10.3390/fractalfract8030175
ER  - 

@article{
author = "Bauman, Neda and Srbljanović, Jelena and Čolović Čalovski, Ivana and Lijeskić, Olivera and Ćirković, Vladimir and Trajković, Jelena and Bobić, Branko and Ilić, Andjelija Ž and Štajner, Tijana",
year = "2024",
abstract = "Toxoplasma gondii is an obligate intracellular parasite existing in three infectious life stages—tachyzoites, bradyzoites, and sporozoites. Rupture of tissue cysts and re-conversion of bradyzoites to tachyzoites leads to reactivated toxoplasmosis (RT) in an immunocompromised host. The aim of this study was to apply ImageJ software for analysis of T. gondii brain cysts obtained from a newly established in vivo model of RT. Mice chronically infected with T. gondii (BGD1 and BGD26 strains) were treated with cyclophosphamide and hydrocortisone (experimental group—EG) or left untreated as infection controls (ICs). RT in mice was confirmed by qPCR (PCR+); mice remaining chronically infected were PCR−. A total of 90 images of cysts were analyzed for fractal dimension (FD), lacunarity (L), diameter (D), circularity (C), and packing density (PD). Circularity was significantly higher in PCR+ compared to IC mice (p < 0.05 for BGD1, p < 0.001 for the BGD26 strain). A significant negative correlation between D and PD was observed only in IC for the BGD1 strain (ρ = −0.384, p = 0.048), while fractal parameters were stable. Significantly higher D, C, and PD and lower lacunarity, L, were noticed in the BGD1 compared to the more aggressive BGD26 strain. In conclusion, these results demonstrate the complexity of structural alterations of T. gondii cysts in an immunocompromised host and emphasize the application potential of ImageJ in the experimental models of toxoplasmosis.",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Fractal and Fractional, Fractal and Fractional",
title = "Structural Characterization of Toxoplasma gondii Brain Cysts in a Model of Reactivated Toxoplasmosis Using Computational Image Analysis",
number = "3",
pages = "175",
volume = "8",
doi = "10.3390/fractalfract8030175"
}

Bauman, N., Srbljanović, J., Čolović Čalovski, I., Lijeskić, O., Ćirković, V., Trajković, J., Bobić, B., Ilić, A. Ž.,& Štajner, T.. (2024). Structural Characterization of Toxoplasma gondii Brain Cysts in a Model of Reactivated Toxoplasmosis Using Computational Image Analysis. in Fractal and Fractional
Multidisciplinary Digital Publishing Institute (MDPI)., 8(3), 175.
https://doi.org/10.3390/fractalfract8030175

Bauman N, Srbljanović J, Čolović Čalovski I, Lijeskić O, Ćirković V, Trajković J, Bobić B, Ilić AŽ, Štajner T. Structural Characterization of Toxoplasma gondii Brain Cysts in a Model of Reactivated Toxoplasmosis Using Computational Image Analysis. in Fractal and Fractional. 2024;8(3):175.
doi:10.3390/fractalfract8030175 .

Bauman, Neda, Srbljanović, Jelena, Čolović Čalovski, Ivana, Lijeskić, Olivera, Ćirković, Vladimir, Trajković, Jelena, Bobić, Branko, Ilić, Andjelija Ž, Štajner, Tijana, "Structural Characterization of Toxoplasma gondii Brain Cysts in a Model of Reactivated Toxoplasmosis Using Computational Image Analysis" in Fractal and Fractional, 8, no. 3 (2024):175,
https://doi.org/10.3390/fractalfract8030175 . .

TY  - JOUR
AU  - Amorim, Tânia
AU  - Trivanović, Drenka
AU  - Benova, Andrea
AU  - Li, Hongshuai
AU  - Tencerova, Michaela
AU  - Palmisano, Biagio
PY  - 2024
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1472
AB  - Bone marrow adiposity (BMA) is a rapidly growing yet very young research field that is receiving worldwide attention based on its intimate relationship with skeletal and metabolic diseases, as well as hematology and cancer. Moreover, increasing numbers of young scientists and students are currently and actively working on BMA within their research projects. These developments led to the foundation of the International Bone Marrow Adiposity Society (BMAS), with the goal to promote BMA knowledge worldwide, and to train new generations of researchers interested in studying this field. Among the many initiatives supported by BMAS, there is the BMAS Summer School, inaugurated in 2021 and now at its second edition. The aim of the BMAS Summer School 2023 was to educate and train students by disseminating the latest advancement on BMA. Moreover, Summer School 2023 provided suggestions on how to write grants, deal with negative results in science, and start a laboratory, along with illustrations of alternative paths to academia. The event was animated by constructive and interactive discussions between early-career researchers and more senior scientists. In this report, we highlight key moments and lessons learned from the event.
PB  - Company of Biologists Ltd.
T2  - Biology Open
T1  - Young minds, deeper insights: a recap of the BMAS Summer School 2023, ranging from basic research to clinical implications of bone marrow adipose tissue
IS  - 2
SP  - bio060263
VL  - 13
DO  - 10.1242/bio.060263
ER  - 

@article{
author = "Amorim, Tânia and Trivanović, Drenka and Benova, Andrea and Li, Hongshuai and Tencerova, Michaela and Palmisano, Biagio",
year = "2024",
abstract = "Bone marrow adiposity (BMA) is a rapidly growing yet very young research field that is receiving worldwide attention based on its intimate relationship with skeletal and metabolic diseases, as well as hematology and cancer. Moreover, increasing numbers of young scientists and students are currently and actively working on BMA within their research projects. These developments led to the foundation of the International Bone Marrow Adiposity Society (BMAS), with the goal to promote BMA knowledge worldwide, and to train new generations of researchers interested in studying this field. Among the many initiatives supported by BMAS, there is the BMAS Summer School, inaugurated in 2021 and now at its second edition. The aim of the BMAS Summer School 2023 was to educate and train students by disseminating the latest advancement on BMA. Moreover, Summer School 2023 provided suggestions on how to write grants, deal with negative results in science, and start a laboratory, along with illustrations of alternative paths to academia. The event was animated by constructive and interactive discussions between early-career researchers and more senior scientists. In this report, we highlight key moments and lessons learned from the event.",
publisher = "Company of Biologists Ltd.",
journal = "Biology Open",
title = "Young minds, deeper insights: a recap of the BMAS Summer School 2023, ranging from basic research to clinical implications of bone marrow adipose tissue",
number = "2",
pages = "bio060263",
volume = "13",
doi = "10.1242/bio.060263"
}

Amorim, T., Trivanović, D., Benova, A., Li, H., Tencerova, M.,& Palmisano, B.. (2024). Young minds, deeper insights: a recap of the BMAS Summer School 2023, ranging from basic research to clinical implications of bone marrow adipose tissue. in Biology Open
Company of Biologists Ltd.., 13(2), bio060263.
https://doi.org/10.1242/bio.060263

Amorim T, Trivanović D, Benova A, Li H, Tencerova M, Palmisano B. Young minds, deeper insights: a recap of the BMAS Summer School 2023, ranging from basic research to clinical implications of bone marrow adipose tissue. in Biology Open. 2024;13(2):bio060263.
doi:10.1242/bio.060263 .

Amorim, Tânia, Trivanović, Drenka, Benova, Andrea, Li, Hongshuai, Tencerova, Michaela, Palmisano, Biagio, "Young minds, deeper insights: a recap of the BMAS Summer School 2023, ranging from basic research to clinical implications of bone marrow adipose tissue" in Biology Open, 13, no. 2 (2024):bio060263,
https://doi.org/10.1242/bio.060263 . .