TY  - JOUR
AU  - Cabreira, Verónica
AU  - Alty, Jane
AU  - Antić, Sonja
AU  - Araújo, Rui
AU  - Aybek, Selma
AU  - Ball, Harriet A.
AU  - Baslet, Gaston
AU  - Bhome, Rohan
AU  - Coebergh, Jan
AU  - Dubois, Bruno
AU  - Edwards, Mark
AU  - Filipović, Saša
AU  - Frederiksen, Kristian Steen
AU  - Harbo, Thomas
AU  - Hayhow, Bradleigh
AU  - Howard, Robert
AU  - Huntley, Jonathan
AU  - Isaacs, Jeremy
AU  - LaFrance Jr., William Curt
AU  - Larner, Andrew J.
AU  - Di Lorenzo, Francesco
AU  - Main, James
AU  - Mallam, Elizabeth
AU  - Marra, Camillo
AU  - Massano, João
AU  - McGrath, Emer R.
AU  - McWhirter, Laura
AU  - Moreira, Isabel Portela
AU  - Nobili, Flavio
AU  - Pennington, Catherine
AU  - Tábuas-Pereira, Miguel
AU  - Perez, David L.
AU  - Popkirov, Stoyan
AU  - Rayment, Dane
AU  - Rossor, Martin
AU  - Russo, Mirella
AU  - Santana, Isabel
AU  - Schott, Jonathan
AU  - Scott, Emmi P.
AU  - Taipa, Ricardo
AU  - Tinazzi, Michele
AU  - Tomić, Svetlana
AU  - Toniolo, Sofia
AU  - Tørring, Caroline Winther
AU  - Wilkinson, Tim
AU  - Frostholm, Lisbeth
AU  - Stone, Jon
AU  - Carson, Alan
PY  - 2024
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1481
AB  - Background: Current proposed criteria for functional cognitive disorder (FCD) have not been externally validated. We sought to analyse the current perspectives of cognitive specialists in the diagnosis and management of FCD in comparison with neurodegenerative conditions. Methods: International experts in cognitive disorders were invited to assess seven illustrative clinical vignettes containing history and bedside characteristics alone. Participants assigned a probable diagnosis and selected the appropriate investigation and treatment. Qualitative, quantitative and inter-rater agreement analyses were undertaken. Results: Eighteen diagnostic terminologies were assigned by 45 cognitive experts from 12 countries with a median of 13 years of experience, across the seven scenarios. Accurate discrimination between FCD and neurodegeneration was observed, independently of background and years of experience: 100% of the neurodegenerative vignettes were correctly classified and 75%–88% of the FCD diagnoses were attributed to non-neurodegenerative causes. There was <50% agreement in the terminology used for FCD, in comparison with 87%–92% agreement for neurodegenerative syndromes. Blood tests and neuropsychological evaluation were the leading diagnostic modalities for FCD. Diagnostic communication, psychotherapy and psychiatry referral were the main suggested management strategies in FCD. Conclusions: Our study demonstrates the feasibility of distinguishing between FCD and neurodegeneration based on relevant patient characteristics and history details. These characteristics need further validation and operationalisation. Heterogeneous labelling and framing pose clinical and research challenges reflecting a lack of agreement in the field. Careful consideration of FCD diagnosis is advised, particularly in the presence of comorbidities. This study informs future research on diagnostic tools and evidence-based interventions.
PB  - Wiley-Blackwell
T2  - European Journal of Neurology
T2  - European Journal of Neurology
T1  - Perspectives on the diagnosis and management of functional cognitive disorder: An international Delphi study
IS  - n/a
SP  - e16318
VL  - n/a
DO  - 10.1111/ene.16318
ER  - 

@article{
author = "Cabreira, Verónica and Alty, Jane and Antić, Sonja and Araújo, Rui and Aybek, Selma and Ball, Harriet A. and Baslet, Gaston and Bhome, Rohan and Coebergh, Jan and Dubois, Bruno and Edwards, Mark and Filipović, Saša and Frederiksen, Kristian Steen and Harbo, Thomas and Hayhow, Bradleigh and Howard, Robert and Huntley, Jonathan and Isaacs, Jeremy and LaFrance Jr., William Curt and Larner, Andrew J. and Di Lorenzo, Francesco and Main, James and Mallam, Elizabeth and Marra, Camillo and Massano, João and McGrath, Emer R. and McWhirter, Laura and Moreira, Isabel Portela and Nobili, Flavio and Pennington, Catherine and Tábuas-Pereira, Miguel and Perez, David L. and Popkirov, Stoyan and Rayment, Dane and Rossor, Martin and Russo, Mirella and Santana, Isabel and Schott, Jonathan and Scott, Emmi P. and Taipa, Ricardo and Tinazzi, Michele and Tomić, Svetlana and Toniolo, Sofia and Tørring, Caroline Winther and Wilkinson, Tim and Frostholm, Lisbeth and Stone, Jon and Carson, Alan",
year = "2024",
abstract = "Background: Current proposed criteria for functional cognitive disorder (FCD) have not been externally validated. We sought to analyse the current perspectives of cognitive specialists in the diagnosis and management of FCD in comparison with neurodegenerative conditions. Methods: International experts in cognitive disorders were invited to assess seven illustrative clinical vignettes containing history and bedside characteristics alone. Participants assigned a probable diagnosis and selected the appropriate investigation and treatment. Qualitative, quantitative and inter-rater agreement analyses were undertaken. Results: Eighteen diagnostic terminologies were assigned by 45 cognitive experts from 12 countries with a median of 13 years of experience, across the seven scenarios. Accurate discrimination between FCD and neurodegeneration was observed, independently of background and years of experience: 100% of the neurodegenerative vignettes were correctly classified and 75%–88% of the FCD diagnoses were attributed to non-neurodegenerative causes. There was <50% agreement in the terminology used for FCD, in comparison with 87%–92% agreement for neurodegenerative syndromes. Blood tests and neuropsychological evaluation were the leading diagnostic modalities for FCD. Diagnostic communication, psychotherapy and psychiatry referral were the main suggested management strategies in FCD. Conclusions: Our study demonstrates the feasibility of distinguishing between FCD and neurodegeneration based on relevant patient characteristics and history details. These characteristics need further validation and operationalisation. Heterogeneous labelling and framing pose clinical and research challenges reflecting a lack of agreement in the field. Careful consideration of FCD diagnosis is advised, particularly in the presence of comorbidities. This study informs future research on diagnostic tools and evidence-based interventions.",
publisher = "Wiley-Blackwell",
journal = "European Journal of Neurology, European Journal of Neurology",
title = "Perspectives on the diagnosis and management of functional cognitive disorder: An international Delphi study",
number = "n/a",
pages = "e16318",
volume = "n/a",
doi = "10.1111/ene.16318"
}

Cabreira, V., Alty, J., Antić, S., Araújo, R., Aybek, S., Ball, H. A., Baslet, G., Bhome, R., Coebergh, J., Dubois, B., Edwards, M., Filipović, S., Frederiksen, K. S., Harbo, T., Hayhow, B., Howard, R., Huntley, J., Isaacs, J., LaFrance Jr., W. C., Larner, A. J., Di Lorenzo, F., Main, J., Mallam, E., Marra, C., Massano, J., McGrath, E. R., McWhirter, L., Moreira, I. P., Nobili, F., Pennington, C., Tábuas-Pereira, M., Perez, D. L., Popkirov, S., Rayment, D., Rossor, M., Russo, M., Santana, I., Schott, J., Scott, E. P., Taipa, R., Tinazzi, M., Tomić, S., Toniolo, S., Tørring, C. W., Wilkinson, T., Frostholm, L., Stone, J.,& Carson, A.. (2024). Perspectives on the diagnosis and management of functional cognitive disorder: An international Delphi study. in European Journal of Neurology
Wiley-Blackwell., n/a(n/a), e16318.
https://doi.org/10.1111/ene.16318

Cabreira V, Alty J, Antić S, Araújo R, Aybek S, Ball HA, Baslet G, Bhome R, Coebergh J, Dubois B, Edwards M, Filipović S, Frederiksen KS, Harbo T, Hayhow B, Howard R, Huntley J, Isaacs J, LaFrance Jr. WC, Larner AJ, Di Lorenzo F, Main J, Mallam E, Marra C, Massano J, McGrath ER, McWhirter L, Moreira IP, Nobili F, Pennington C, Tábuas-Pereira M, Perez DL, Popkirov S, Rayment D, Rossor M, Russo M, Santana I, Schott J, Scott EP, Taipa R, Tinazzi M, Tomić S, Toniolo S, Tørring CW, Wilkinson T, Frostholm L, Stone J, Carson A. Perspectives on the diagnosis and management of functional cognitive disorder: An international Delphi study. in European Journal of Neurology. 2024;n/a(n/a):e16318.
doi:10.1111/ene.16318 .

Cabreira, Verónica, Alty, Jane, Antić, Sonja, Araújo, Rui, Aybek, Selma, Ball, Harriet A., Baslet, Gaston, Bhome, Rohan, Coebergh, Jan, Dubois, Bruno, Edwards, Mark, Filipović, Saša, Frederiksen, Kristian Steen, Harbo, Thomas, Hayhow, Bradleigh, Howard, Robert, Huntley, Jonathan, Isaacs, Jeremy, LaFrance Jr., William Curt, Larner, Andrew J., Di Lorenzo, Francesco, Main, James, Mallam, Elizabeth, Marra, Camillo, Massano, João, McGrath, Emer R., McWhirter, Laura, Moreira, Isabel Portela, Nobili, Flavio, Pennington, Catherine, Tábuas-Pereira, Miguel, Perez, David L., Popkirov, Stoyan, Rayment, Dane, Rossor, Martin, Russo, Mirella, Santana, Isabel, Schott, Jonathan, Scott, Emmi P., Taipa, Ricardo, Tinazzi, Michele, Tomić, Svetlana, Toniolo, Sofia, Tørring, Caroline Winther, Wilkinson, Tim, Frostholm, Lisbeth, Stone, Jon, Carson, Alan, "Perspectives on the diagnosis and management of functional cognitive disorder: An international Delphi study" in European Journal of Neurology, n/a, no. n/a (2024):e16318,
https://doi.org/10.1111/ene.16318 . .