TY  - JOUR
AU  - Rasin, Puthiyavalappil
AU  - Basheer, Sabeel M.
AU  - Haribabu, Jebiti
AU  - Aneesrahman, K. N.
AU  - Manakkadan, Vipin
AU  - Vadakkedathu Palakkeezhillam, Vishnunarayanan Namboothiri
AU  - Bhuvanesh, Nattamai
AU  - Echeverria, Cesar
AU  - Santibanez, Juan F.
AU  - Sreekanth, Anandaram
PY  - 2024
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1463
AB  - A novel Coumarin-based 1,2-pyrazole, HCPyTSC is synthesised and characterized. The chemosensor has been shown to have efficient colourimetric and fluorescence sensing capabilities for the quick and selective detection of fluoride and copper ions. At 376 and 430 nm, the HCPyTSC exhibits selective sensing for Cu2+ and F− ions. By examining the natural bond orbital (NBO) analysis and the potential energy curve (PES) of the ground state for the function of the C–H bond, it has been determined from the theoretical study at hand that the deprotonation was taken from the ‘CH’ proton of the pyrazole ring. For F− and Cu2+, the HCPyTSC detection limits were 4.62 nM and 15.36 nM, respectively. Similarly, the binding constants (Kb) for F− and Cu2+ ions in acetonitrile medium were found to be 2.06 × 105 M−1 and 1.88 × 105 M−1. Chemosensor HCPyTSC with and without F− and Cu2+ ions have an emission and absorption response that can imitate a variety of logic gates, including the AND, XOR, and OR gates. Additionally, a paper-based sensor strip with the HCPyTSC was created for use in practical, flexible F− sensing applications. The paper-based sensor was more effective in detecting F− than other anions. The effectiveness of HCPyTSC for the selective detection of F− in living cells as well as its cell permeability were examined using live-cell imaging in T24 cells.
PB  - Elsevier
T2  - Heliyon
T1  - Host-guest interactions of coumarin-based 1,2-pyrazole using analytical and computational methods: Paper strip-based detection, live cell imaging, logic gates and keypad lock applications
IS  - 1
SP  - e24077
VL  - 10
DO  - 10.1016/j.heliyon.2024.e24077
ER  - 

@article{
author = "Rasin, Puthiyavalappil and Basheer, Sabeel M. and Haribabu, Jebiti and Aneesrahman, K. N. and Manakkadan, Vipin and Vadakkedathu Palakkeezhillam, Vishnunarayanan Namboothiri and Bhuvanesh, Nattamai and Echeverria, Cesar and Santibanez, Juan F. and Sreekanth, Anandaram",
year = "2024",
abstract = "A novel Coumarin-based 1,2-pyrazole, HCPyTSC is synthesised and characterized. The chemosensor has been shown to have efficient colourimetric and fluorescence sensing capabilities for the quick and selective detection of fluoride and copper ions. At 376 and 430 nm, the HCPyTSC exhibits selective sensing for Cu2+ and F− ions. By examining the natural bond orbital (NBO) analysis and the potential energy curve (PES) of the ground state for the function of the C–H bond, it has been determined from the theoretical study at hand that the deprotonation was taken from the ‘CH’ proton of the pyrazole ring. For F− and Cu2+, the HCPyTSC detection limits were 4.62 nM and 15.36 nM, respectively. Similarly, the binding constants (Kb) for F− and Cu2+ ions in acetonitrile medium were found to be 2.06 × 105 M−1 and 1.88 × 105 M−1. Chemosensor HCPyTSC with and without F− and Cu2+ ions have an emission and absorption response that can imitate a variety of logic gates, including the AND, XOR, and OR gates. Additionally, a paper-based sensor strip with the HCPyTSC was created for use in practical, flexible F− sensing applications. The paper-based sensor was more effective in detecting F− than other anions. The effectiveness of HCPyTSC for the selective detection of F− in living cells as well as its cell permeability were examined using live-cell imaging in T24 cells.",
publisher = "Elsevier",
journal = "Heliyon",
title = "Host-guest interactions of coumarin-based 1,2-pyrazole using analytical and computational methods: Paper strip-based detection, live cell imaging, logic gates and keypad lock applications",
number = "1",
pages = "e24077",
volume = "10",
doi = "10.1016/j.heliyon.2024.e24077"
}

Rasin, P., Basheer, S. M., Haribabu, J., Aneesrahman, K. N., Manakkadan, V., Vadakkedathu Palakkeezhillam, V. N., Bhuvanesh, N., Echeverria, C., Santibanez, J. F.,& Sreekanth, A.. (2024). Host-guest interactions of coumarin-based 1,2-pyrazole using analytical and computational methods: Paper strip-based detection, live cell imaging, logic gates and keypad lock applications. in Heliyon
Elsevier., 10(1), e24077.
https://doi.org/10.1016/j.heliyon.2024.e24077

Rasin P, Basheer SM, Haribabu J, Aneesrahman KN, Manakkadan V, Vadakkedathu Palakkeezhillam VN, Bhuvanesh N, Echeverria C, Santibanez JF, Sreekanth A. Host-guest interactions of coumarin-based 1,2-pyrazole using analytical and computational methods: Paper strip-based detection, live cell imaging, logic gates and keypad lock applications. in Heliyon. 2024;10(1):e24077.
doi:10.1016/j.heliyon.2024.e24077 .

Rasin, Puthiyavalappil, Basheer, Sabeel M., Haribabu, Jebiti, Aneesrahman, K. N., Manakkadan, Vipin, Vadakkedathu Palakkeezhillam, Vishnunarayanan Namboothiri, Bhuvanesh, Nattamai, Echeverria, Cesar, Santibanez, Juan F., Sreekanth, Anandaram, "Host-guest interactions of coumarin-based 1,2-pyrazole using analytical and computational methods: Paper strip-based detection, live cell imaging, logic gates and keypad lock applications" in Heliyon, 10, no. 1 (2024):e24077,
https://doi.org/10.1016/j.heliyon.2024.e24077 . .

TY  - JOUR
AU  - Vadakkedathu Palakkeezhillam, Vishnunarayanan Namboothiri
AU  - Haribabu, Jebiti
AU  - Suresh Kumar, Vaishnu
AU  - Manakkadan, Vipin
AU  - Rasin, Puthiyavalappil
AU  - Bhuvanesh, Nattamai
AU  - Echeverria, Cesar
AU  - Santibanez, Juan F.
AU  - Sreekanth, Anandaram
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1325
AB  - A couple of N-(4)-morpholine/pyrrolidine-substituted thiosemicarbazones (TSCs) of fluorene-2-carboxaldehyde (FM and FP), and their corresponding thiadiazoles (TDZs) (CFM and CFP), were synthesized and characterized (elemental analysis, ultraviolet–visible [UV–Visible], Fourier transform infrared [FT-IR], nuclear magnetic resonance [NMR; 1H & 13C], high-resolution mass spectrometry [HRMS], and single-crystal X-ray diffraction [SCXRD]) for the evaluation of their anticancer potential. The TDZs were obtained unexpectedly and are possibly formed via single-step metal (copper)-mediated oxidative cyclizations of the TSCs. The synthesized compounds are fairly stable in phosphate buffer at the biological pH of 7.4. The density functional theory [DFT] studies were performed to predict the optimized structures and physicochemical properties of these compounds. The compounds were further subjected to computational and experimental biomolecular investigations in order to evaluate their anticancer activity in detail. CFM had the most potent activity against human breast adenocarcinoma (MCF-7) and human urinary bladder (T24) cancer cells, with IC50 values of 12.00 and 24.80 μM, respectively. In contrast, CFM had negligible cytotoxicity (IC50 = 98.70 μM) against kidney epithelial cells extracted from an African green monkey (Vero) normal cells. This outcome was preferable to that of the widely used medicine Cisplatin. Molecular docking studies were performed with the breast cancer protein “cytochrome P450 1A1” (CYP1A1) and bovine serum albumin (BSA) to predict how effectively the compounds bind to the receptor. The ADMET findings suggest that these compounds have considerable drug-likeness and oral bioavailability. These insights may open the door for additional medical research into the bioactivities of TSCs and TDZs produced from bioactive carbonyl compounds.
PB  - Wiley-Blackwell
T2  - Applied Organometallic Chemistry
T1  - Exploring the anticancer potential of thiadiazole derivatives of substituted thiosemicarbazones formed via copper-mediated cyclization
IS  - 8
SP  - e7174
VL  - 37
DO  - 10.1002/aoc.7174
ER  - 

@article{
author = "Vadakkedathu Palakkeezhillam, Vishnunarayanan Namboothiri and Haribabu, Jebiti and Suresh Kumar, Vaishnu and Manakkadan, Vipin and Rasin, Puthiyavalappil and Bhuvanesh, Nattamai and Echeverria, Cesar and Santibanez, Juan F. and Sreekanth, Anandaram",
year = "2023",
abstract = "A couple of N-(4)-morpholine/pyrrolidine-substituted thiosemicarbazones (TSCs) of fluorene-2-carboxaldehyde (FM and FP), and their corresponding thiadiazoles (TDZs) (CFM and CFP), were synthesized and characterized (elemental analysis, ultraviolet–visible [UV–Visible], Fourier transform infrared [FT-IR], nuclear magnetic resonance [NMR; 1H & 13C], high-resolution mass spectrometry [HRMS], and single-crystal X-ray diffraction [SCXRD]) for the evaluation of their anticancer potential. The TDZs were obtained unexpectedly and are possibly formed via single-step metal (copper)-mediated oxidative cyclizations of the TSCs. The synthesized compounds are fairly stable in phosphate buffer at the biological pH of 7.4. The density functional theory [DFT] studies were performed to predict the optimized structures and physicochemical properties of these compounds. The compounds were further subjected to computational and experimental biomolecular investigations in order to evaluate their anticancer activity in detail. CFM had the most potent activity against human breast adenocarcinoma (MCF-7) and human urinary bladder (T24) cancer cells, with IC50 values of 12.00 and 24.80 μM, respectively. In contrast, CFM had negligible cytotoxicity (IC50 = 98.70 μM) against kidney epithelial cells extracted from an African green monkey (Vero) normal cells. This outcome was preferable to that of the widely used medicine Cisplatin. Molecular docking studies were performed with the breast cancer protein “cytochrome P450 1A1” (CYP1A1) and bovine serum albumin (BSA) to predict how effectively the compounds bind to the receptor. The ADMET findings suggest that these compounds have considerable drug-likeness and oral bioavailability. These insights may open the door for additional medical research into the bioactivities of TSCs and TDZs produced from bioactive carbonyl compounds.",
publisher = "Wiley-Blackwell",
journal = "Applied Organometallic Chemistry",
title = "Exploring the anticancer potential of thiadiazole derivatives of substituted thiosemicarbazones formed via copper-mediated cyclization",
number = "8",
pages = "e7174",
volume = "37",
doi = "10.1002/aoc.7174"
}

Vadakkedathu Palakkeezhillam, V. N., Haribabu, J., Suresh Kumar, V., Manakkadan, V., Rasin, P., Bhuvanesh, N., Echeverria, C., Santibanez, J. F.,& Sreekanth, A.. (2023). Exploring the anticancer potential of thiadiazole derivatives of substituted thiosemicarbazones formed via copper-mediated cyclization. in Applied Organometallic Chemistry
Wiley-Blackwell., 37(8), e7174.
https://doi.org/10.1002/aoc.7174

Vadakkedathu Palakkeezhillam VN, Haribabu J, Suresh Kumar V, Manakkadan V, Rasin P, Bhuvanesh N, Echeverria C, Santibanez JF, Sreekanth A. Exploring the anticancer potential of thiadiazole derivatives of substituted thiosemicarbazones formed via copper-mediated cyclization. in Applied Organometallic Chemistry. 2023;37(8):e7174.
doi:10.1002/aoc.7174 .

Vadakkedathu Palakkeezhillam, Vishnunarayanan Namboothiri, Haribabu, Jebiti, Suresh Kumar, Vaishnu, Manakkadan, Vipin, Rasin, Puthiyavalappil, Bhuvanesh, Nattamai, Echeverria, Cesar, Santibanez, Juan F., Sreekanth, Anandaram, "Exploring the anticancer potential of thiadiazole derivatives of substituted thiosemicarbazones formed via copper-mediated cyclization" in Applied Organometallic Chemistry, 37, no. 8 (2023):e7174,
https://doi.org/10.1002/aoc.7174 . .

TY  - JOUR
AU  - Santibanez, Juan F.
AU  - Villar, Victor H.
AU  - Echeverria, Cesar
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1291
T2  - Pharmaceutics
T1  - Current and Future Cancer Chemoprevention Strategies
IS  - 5
SP  - 1543
VL  - 15
DO  - 10.3390/pharmaceutics15051543
ER  - 

@article{
author = "Santibanez, Juan F. and Villar, Victor H. and Echeverria, Cesar",
year = "2023",
journal = "Pharmaceutics",
title = "Current and Future Cancer Chemoprevention Strategies",
number = "5",
pages = "1543",
volume = "15",
doi = "10.3390/pharmaceutics15051543"
}

Santibanez, J. F., Villar, V. H.,& Echeverria, C.. (2023). Current and Future Cancer Chemoprevention Strategies. in Pharmaceutics, 15(5), 1543.
https://doi.org/10.3390/pharmaceutics15051543

Santibanez JF, Villar VH, Echeverria C. Current and Future Cancer Chemoprevention Strategies. in Pharmaceutics. 2023;15(5):1543.
doi:10.3390/pharmaceutics15051543 .

Santibanez, Juan F., Villar, Victor H., Echeverria, Cesar, "Current and Future Cancer Chemoprevention Strategies" in Pharmaceutics, 15, no. 5 (2023):1543,
https://doi.org/10.3390/pharmaceutics15051543 . .

TY  - JOUR
AU  - Ramirez-Tagle, Rodrigo
AU  - Alvarado-Soto, Leonor
AU  - Santibanez, Juan F.
AU  - Echeverria, Cesar
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1361
AB  - Relationships between the structural characteristic of curcumin and dimethoxycurcumin and their antitumoral activity were studied. Treatment of HepG2 cells for 24 h with the curcumin and dimethoxycurcumin resulted in apoptosis induction and dose-dependent inhibition of cell proliferation. The calculated docking and the DFT method, suggest a structure-activity relationship between the activities of dimethoxycurcumin and curcumin structure and the apoptosis in HepG2 cells
PB  - Asociacion de Quimicos del Instituto Quimico de Sarria
T2  - Afinidad. Journal of Chemical Engineering Theoretical and Applied Chemistry
T2  - Afinidad. Journal of Chemical Engineering Theoretical and Applied Chemistry
T1  - Relationships between the structural characteristic of curcumins that affect cell proliferation of hepatocarcinoma cells
EP  - 179
IS  - 599
SP  - 175
VL  - 80
DO  - 10.55815/417980
ER  - 

@article{
author = "Ramirez-Tagle, Rodrigo and Alvarado-Soto, Leonor and Santibanez, Juan F. and Echeverria, Cesar",
year = "2023",
abstract = "Relationships between the structural characteristic of curcumin and dimethoxycurcumin and their antitumoral activity were studied. Treatment of HepG2 cells for 24 h with the curcumin and dimethoxycurcumin resulted in apoptosis induction and dose-dependent inhibition of cell proliferation. The calculated docking and the DFT method, suggest a structure-activity relationship between the activities of dimethoxycurcumin and curcumin structure and the apoptosis in HepG2 cells",
publisher = "Asociacion de Quimicos del Instituto Quimico de Sarria",
journal = "Afinidad. Journal of Chemical Engineering Theoretical and Applied Chemistry, Afinidad. Journal of Chemical Engineering Theoretical and Applied Chemistry",
title = "Relationships between the structural characteristic of curcumins that affect cell proliferation of hepatocarcinoma cells",
pages = "179-175",
number = "599",
volume = "80",
doi = "10.55815/417980"
}

Ramirez-Tagle, R., Alvarado-Soto, L., Santibanez, J. F.,& Echeverria, C.. (2023). Relationships between the structural characteristic of curcumins that affect cell proliferation of hepatocarcinoma cells. in Afinidad. Journal of Chemical Engineering Theoretical and Applied Chemistry
Asociacion de Quimicos del Instituto Quimico de Sarria., 80(599), 175-179.
https://doi.org/10.55815/417980

Ramirez-Tagle R, Alvarado-Soto L, Santibanez JF, Echeverria C. Relationships between the structural characteristic of curcumins that affect cell proliferation of hepatocarcinoma cells. in Afinidad. Journal of Chemical Engineering Theoretical and Applied Chemistry. 2023;80(599):175-179.
doi:10.55815/417980 .

Ramirez-Tagle, Rodrigo, Alvarado-Soto, Leonor, Santibanez, Juan F., Echeverria, Cesar, "Relationships between the structural characteristic of curcumins that affect cell proliferation of hepatocarcinoma cells" in Afinidad. Journal of Chemical Engineering Theoretical and Applied Chemistry, 80, no. 599 (2023):175-179,
https://doi.org/10.55815/417980 . .

TY  - JOUR
AU  - Prado, Yolanda
AU  - Echeverría, Cesar
AU  - Feijóo, Carmen G.
AU  - Riedel, Claudia A.
AU  - Cabello-Verrugio, Claudio
AU  - Santibanez, Juan F.
AU  - Simon, Felipe
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1296
AB  - Sepsis syndrome develops through enhanced secretion of pro-inflammatory cytokines and the generation of reactive oxygen species (ROS). Sepsis syndrome is characterized by vascular hyperpermeability, hypotension, multiple organ dysfunction syndrome (MODS), and increased mortality, among others. Endotoxemia-derived sepsis is an important cause of sepsis syndrome. During endotoxemia, circulating endotoxin interacts with endothelial cells (ECs), inducing detrimental effects on endothelium function. The endotoxin induces the conversion of ECs into fibroblasts, which are characterized by a massive change in the endothelial gene-expression pattern. This downregulates the endothelial markers and upregulates fibrotic proteins, mesenchymal transcription factors, and extracellular matrix proteins, producing endothelial fibrosis. Sepsis progression is modulated by the consumption of specific nutrients, including ω-3 fatty acids, ascorbic acid, and polyphenolic antioxidant flavonoids. However, the underlying mechanism is poorly described. The notion that gene expression is modulated during inflammatory conditions by nutrient consumption has been reported. However, it is not known whether nutrient consumption modulates the fibrotic endothelial gene-expression pattern during sepsis as a mechanism to decrease vascular hyperpermeability, hypotension, MODS, and mortality. Therefore, the aim of this study was to investigate the impact of the consumption of dietary ω-3 fatty acids, ascorbic acid, and polyphenolic antioxidant flavonoid supplements on the modulation of fibrotic endothelial gene-expression patterns during sepsis and to determine the effects on sepsis outcomes. Our results indicate that the consumption of supplements based on ω-3 fatty acids and polyphenolic antioxidant flavonoids was effective for improving endotoxemia outcomes through prophylactic ingestion and therapeutic usage. Thus, our findings indicated that specific nutrient consumption improves sepsis outcomes and should be considered in treatment.
PB  - MDPI
T2  - Antioxidants
T1  - Effect of Dietary Supplements with ω-3 Fatty Acids, Ascorbic Acid, and Polyphenolic Antioxidant Flavonoid on Gene Expression, Organ Failure, and Mortality in Endotoxemia-Induced Septic Rats
IS  - 3
SP  - 659
VL  - 12
DO  - 10.3390/antiox12030659
ER  - 

@article{
author = "Prado, Yolanda and Echeverría, Cesar and Feijóo, Carmen G. and Riedel, Claudia A. and Cabello-Verrugio, Claudio and Santibanez, Juan F. and Simon, Felipe",
year = "2023",
abstract = "Sepsis syndrome develops through enhanced secretion of pro-inflammatory cytokines and the generation of reactive oxygen species (ROS). Sepsis syndrome is characterized by vascular hyperpermeability, hypotension, multiple organ dysfunction syndrome (MODS), and increased mortality, among others. Endotoxemia-derived sepsis is an important cause of sepsis syndrome. During endotoxemia, circulating endotoxin interacts with endothelial cells (ECs), inducing detrimental effects on endothelium function. The endotoxin induces the conversion of ECs into fibroblasts, which are characterized by a massive change in the endothelial gene-expression pattern. This downregulates the endothelial markers and upregulates fibrotic proteins, mesenchymal transcription factors, and extracellular matrix proteins, producing endothelial fibrosis. Sepsis progression is modulated by the consumption of specific nutrients, including ω-3 fatty acids, ascorbic acid, and polyphenolic antioxidant flavonoids. However, the underlying mechanism is poorly described. The notion that gene expression is modulated during inflammatory conditions by nutrient consumption has been reported. However, it is not known whether nutrient consumption modulates the fibrotic endothelial gene-expression pattern during sepsis as a mechanism to decrease vascular hyperpermeability, hypotension, MODS, and mortality. Therefore, the aim of this study was to investigate the impact of the consumption of dietary ω-3 fatty acids, ascorbic acid, and polyphenolic antioxidant flavonoid supplements on the modulation of fibrotic endothelial gene-expression patterns during sepsis and to determine the effects on sepsis outcomes. Our results indicate that the consumption of supplements based on ω-3 fatty acids and polyphenolic antioxidant flavonoids was effective for improving endotoxemia outcomes through prophylactic ingestion and therapeutic usage. Thus, our findings indicated that specific nutrient consumption improves sepsis outcomes and should be considered in treatment.",
publisher = "MDPI",
journal = "Antioxidants",
title = "Effect of Dietary Supplements with ω-3 Fatty Acids, Ascorbic Acid, and Polyphenolic Antioxidant Flavonoid on Gene Expression, Organ Failure, and Mortality in Endotoxemia-Induced Septic Rats",
number = "3",
pages = "659",
volume = "12",
doi = "10.3390/antiox12030659"
}

Prado, Y., Echeverría, C., Feijóo, C. G., Riedel, C. A., Cabello-Verrugio, C., Santibanez, J. F.,& Simon, F.. (2023). Effect of Dietary Supplements with ω-3 Fatty Acids, Ascorbic Acid, and Polyphenolic Antioxidant Flavonoid on Gene Expression, Organ Failure, and Mortality in Endotoxemia-Induced Septic Rats. in Antioxidants
MDPI., 12(3), 659.
https://doi.org/10.3390/antiox12030659

Prado Y, Echeverría C, Feijóo CG, Riedel CA, Cabello-Verrugio C, Santibanez JF, Simon F. Effect of Dietary Supplements with ω-3 Fatty Acids, Ascorbic Acid, and Polyphenolic Antioxidant Flavonoid on Gene Expression, Organ Failure, and Mortality in Endotoxemia-Induced Septic Rats. in Antioxidants. 2023;12(3):659.
doi:10.3390/antiox12030659 .

Prado, Yolanda, Echeverría, Cesar, Feijóo, Carmen G., Riedel, Claudia A., Cabello-Verrugio, Claudio, Santibanez, Juan F., Simon, Felipe, "Effect of Dietary Supplements with ω-3 Fatty Acids, Ascorbic Acid, and Polyphenolic Antioxidant Flavonoid on Gene Expression, Organ Failure, and Mortality in Endotoxemia-Induced Septic Rats" in Antioxidants, 12, no. 3 (2023):659,
https://doi.org/10.3390/antiox12030659 . .

TY  - CHAP
AU  - Gatica, Sebastian
AU  - Aravena, Cristobal
AU  - Prado, Yolanda
AU  - Aravena, Diego
AU  - Echeverría, Cesar
AU  - Santibanez, Juan F.
AU  - Riedel, Claudia A.
AU  - Stehberg, Jimmy
AU  - Simon, Felipe
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1380
AB  - Dexmedetomidine is an adrenergic receptor agonist that has been regarded as neuroprotective in several studies without an objective measure to it. Thus, the aim of this meta-analysis was to analyze and quantify the current evidence for the neuroprotective effects of dexmedetomidine in animals. The search was performed by querying the National Library of Medicine. Studies were included based on their language, significancy of their results, and complete availability of data on animal characteristics and interventions. Risk of bias was assessed using SYRCLE’s risk of bias tool and certainty was assessed using the ARRIVE Guidelines 2.0. Synthesis was performed by calculating pooled standardized mean difference and presented in forest plots and tables. The number of eligible records included per outcome is the following: 22 for IL-1β, 13 for IL-6, 19 for apoptosis, 7 for oxidative stress, 7 for Escape Latency, and 4 for Platform Crossings. At the cellular level, dexmedetomidine was found protective against production of IL-1β (standardized mean difference (SMD) =  − 4.3 [− 4.8; − 3.7]) and IL-6 (SMD =  − 5.6 [− 6.7; − 4.6]), apoptosis (measured through TUNEL, SMD =  − 6.0 [− 6.8; − 4.6]), and oxidative stress (measured as MDA production, SMD =  − 2.0 [− 2.4; − 1.4]) exclusively in the central nervous system. At the organism level, dexmedetomidine improved behavioral outcomes measuring escape latency (SMD = − 2.4 [− 3.3; − 1.6]) and number of platform crossings (SMD = 9.1 [− 6.8; − 11.5]). No eligible study had high risk of bias and certainty was satisfactory for reproducibility in all cases. This meta-analysis highlights the complexity of adrenergic stimulation and sheds light into the mechanisms potentiated by dexmedetomidine, which could be exploited for improving current neuroprotective formulations.
PB  - Springer Nature
T2  - Advances in Molecular Pathology
T1  - Appraisal of the Neuroprotective Effect of Dexmedetomidine: A Meta-Analysis
EP  - 181
SP  - 163
DO  - 10.1007/978-3-031-26163-3_9
UR  - https://hdl.handle.net/21.15107/rcub_rimi_1380
ER  - 

@inbook{
author = "Gatica, Sebastian and Aravena, Cristobal and Prado, Yolanda and Aravena, Diego and Echeverría, Cesar and Santibanez, Juan F. and Riedel, Claudia A. and Stehberg, Jimmy and Simon, Felipe",
year = "2023",
abstract = "Dexmedetomidine is an adrenergic receptor agonist that has been regarded as neuroprotective in several studies without an objective measure to it. Thus, the aim of this meta-analysis was to analyze and quantify the current evidence for the neuroprotective effects of dexmedetomidine in animals. The search was performed by querying the National Library of Medicine. Studies were included based on their language, significancy of their results, and complete availability of data on animal characteristics and interventions. Risk of bias was assessed using SYRCLE’s risk of bias tool and certainty was assessed using the ARRIVE Guidelines 2.0. Synthesis was performed by calculating pooled standardized mean difference and presented in forest plots and tables. The number of eligible records included per outcome is the following: 22 for IL-1β, 13 for IL-6, 19 for apoptosis, 7 for oxidative stress, 7 for Escape Latency, and 4 for Platform Crossings. At the cellular level, dexmedetomidine was found protective against production of IL-1β (standardized mean difference (SMD) =  − 4.3 [− 4.8; − 3.7]) and IL-6 (SMD =  − 5.6 [− 6.7; − 4.6]), apoptosis (measured through TUNEL, SMD =  − 6.0 [− 6.8; − 4.6]), and oxidative stress (measured as MDA production, SMD =  − 2.0 [− 2.4; − 1.4]) exclusively in the central nervous system. At the organism level, dexmedetomidine improved behavioral outcomes measuring escape latency (SMD = − 2.4 [− 3.3; − 1.6]) and number of platform crossings (SMD = 9.1 [− 6.8; − 11.5]). No eligible study had high risk of bias and certainty was satisfactory for reproducibility in all cases. This meta-analysis highlights the complexity of adrenergic stimulation and sheds light into the mechanisms potentiated by dexmedetomidine, which could be exploited for improving current neuroprotective formulations.",
publisher = "Springer Nature",
journal = "Advances in Molecular Pathology",
booktitle = "Appraisal of the Neuroprotective Effect of Dexmedetomidine: A Meta-Analysis",
pages = "181-163",
doi = "10.1007/978-3-031-26163-3_9",
url = "https://hdl.handle.net/21.15107/rcub_rimi_1380"
}

Gatica, S., Aravena, C., Prado, Y., Aravena, D., Echeverría, C., Santibanez, J. F., Riedel, C. A., Stehberg, J.,& Simon, F.. (2023). Appraisal of the Neuroprotective Effect of Dexmedetomidine: A Meta-Analysis. in Advances in Molecular Pathology
Springer Nature., 163-181.
https://doi.org/10.1007/978-3-031-26163-3_9
https://hdl.handle.net/21.15107/rcub_rimi_1380

Gatica S, Aravena C, Prado Y, Aravena D, Echeverría C, Santibanez JF, Riedel CA, Stehberg J, Simon F. Appraisal of the Neuroprotective Effect of Dexmedetomidine: A Meta-Analysis. in Advances in Molecular Pathology. 2023;:163-181.
doi:10.1007/978-3-031-26163-3_9
https://hdl.handle.net/21.15107/rcub_rimi_1380 .

Gatica, Sebastian, Aravena, Cristobal, Prado, Yolanda, Aravena, Diego, Echeverría, Cesar, Santibanez, Juan F., Riedel, Claudia A., Stehberg, Jimmy, Simon, Felipe, "Appraisal of the Neuroprotective Effect of Dexmedetomidine: A Meta-Analysis" in Advances in Molecular Pathology (2023):163-181,
https://doi.org/10.1007/978-3-031-26163-3_9 .,
https://hdl.handle.net/21.15107/rcub_rimi_1380 .

TY  - CHAP
AU  - Gatica, Sebastian
AU  - Aravena, Diego
AU  - Echeverría, Cesar
AU  - Santibanez, Juan F.
AU  - Riedel, Claudia A.
AU  - Simon, Felipe
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1390
AB  - Catecholamine stimulation over adrenergic receptors results in a state of hypercoagulability. Chronic stress involves the release and increase in circulation of catecholamines and other stress related hormones. Numerous observational studies in human have related stressful scenarios to several coagulation variables, but controlled stimulation with agonists or antagonists to adrenergic receptors are scarce. This systematic review is aimed at presenting an updated appraisal of the effect of adrenergic receptor modulation on variables related to human hemostasis by systematically reviewing the effect of adrenergic receptor-targeting drugs on scale variables related to hemostasis. By searching 3 databases for articles published between January 1st 2011 and February 16th, 2022 reporting effects on coagulation parameters from stimulation with α- or β-adrenergic receptor targeting drugs in humans regardless of baseline condition, excluding records different from original research and those not addressing the main aim of this systematic review. Risk of bias assessed using the Revised Cochrane risk-of-bias tool for randomized trials (RoB 2). Tables describing a pro-thrombotic anti-fibrinolytic state induced after β-adrenergic receptor agonist stimulation and the opposite after α1-, β-adrenergic receptor antagonist stimulation were synthesized from 4 eligible records by comparing hemostasis-related variables to their baseline. Notwithstanding this low number of records, experimental interventions included were sound and mostly unbiased, results were coherent, and outcomes were biologically plausible. In summary, this systematic review provides a critical systematic assessment and an updated elaboration, and its shortcomings highlight the need for further investigation in the field of hematology.
PB  - Springer Nature
T2  - Advances in Molecular Pathology
T2  - Advances in Molecular Pathology
T1  - Effects of Adrenergic Receptor Stimulation on Human Hemostasis: A Systematic Review
EP  - 63
SP  - 49
DO  - 10.1007/978-3-031-26163-3_3
ER  - 

@inbook{
author = "Gatica, Sebastian and Aravena, Diego and Echeverría, Cesar and Santibanez, Juan F. and Riedel, Claudia A. and Simon, Felipe",
year = "2023",
abstract = "Catecholamine stimulation over adrenergic receptors results in a state of hypercoagulability. Chronic stress involves the release and increase in circulation of catecholamines and other stress related hormones. Numerous observational studies in human have related stressful scenarios to several coagulation variables, but controlled stimulation with agonists or antagonists to adrenergic receptors are scarce. This systematic review is aimed at presenting an updated appraisal of the effect of adrenergic receptor modulation on variables related to human hemostasis by systematically reviewing the effect of adrenergic receptor-targeting drugs on scale variables related to hemostasis. By searching 3 databases for articles published between January 1st 2011 and February 16th, 2022 reporting effects on coagulation parameters from stimulation with α- or β-adrenergic receptor targeting drugs in humans regardless of baseline condition, excluding records different from original research and those not addressing the main aim of this systematic review. Risk of bias assessed using the Revised Cochrane risk-of-bias tool for randomized trials (RoB 2). Tables describing a pro-thrombotic anti-fibrinolytic state induced after β-adrenergic receptor agonist stimulation and the opposite after α1-, β-adrenergic receptor antagonist stimulation were synthesized from 4 eligible records by comparing hemostasis-related variables to their baseline. Notwithstanding this low number of records, experimental interventions included were sound and mostly unbiased, results were coherent, and outcomes were biologically plausible. In summary, this systematic review provides a critical systematic assessment and an updated elaboration, and its shortcomings highlight the need for further investigation in the field of hematology.",
publisher = "Springer Nature",
journal = "Advances in Molecular Pathology, Advances in Molecular Pathology",
booktitle = "Effects of Adrenergic Receptor Stimulation on Human Hemostasis: A Systematic Review",
pages = "63-49",
doi = "10.1007/978-3-031-26163-3_3"
}

Gatica, S., Aravena, D., Echeverría, C., Santibanez, J. F., Riedel, C. A.,& Simon, F.. (2023). Effects of Adrenergic Receptor Stimulation on Human Hemostasis: A Systematic Review. in Advances in Molecular Pathology
Springer Nature., 49-63.
https://doi.org/10.1007/978-3-031-26163-3_3

Gatica S, Aravena D, Echeverría C, Santibanez JF, Riedel CA, Simon F. Effects of Adrenergic Receptor Stimulation on Human Hemostasis: A Systematic Review. in Advances in Molecular Pathology. 2023;:49-63.
doi:10.1007/978-3-031-26163-3_3 .

Gatica, Sebastian, Aravena, Diego, Echeverría, Cesar, Santibanez, Juan F., Riedel, Claudia A., Simon, Felipe, "Effects of Adrenergic Receptor Stimulation on Human Hemostasis: A Systematic Review" in Advances in Molecular Pathology (2023):49-63,
https://doi.org/10.1007/978-3-031-26163-3_3 . .

TY  - JOUR
AU  - Ružić, Dušan
AU  - Đoković, Nemanja
AU  - Srdić-Rajić, Tatjana
AU  - Echeverria, Cesar
AU  - Nikolić, Katarina
AU  - Santibanez, Juan F.
PY  - 2022
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1212
AB  - The dysregulation of gene expression is a critical event involved in all steps of tumorigenesis. Aberrant histone and non-histone acetylation modifications of gene expression due to the abnormal activation of histone deacetylases (HDAC) have been reported in hematologic and solid types of cancer. In this sense, the cancer-associated epigenetic alterations are promising targets for anticancer therapy and chemoprevention. HDAC inhibitors (HDACi) induce histone hyperacetylation within target proteins, altering cell cycle and proliferation, cell differentiation, and the regulation of cell death programs. Over the last three decades, an increasing number of synthetic and naturally derived compounds, such as dietary-derived products, have been demonstrated to act as HDACi and have provided biological and molecular insights with regard to the role of HDAC in cancer. The first part of this review is focused on the biological roles of the Zinc-dependent HDAC family in malignant diseases. Accordingly, the small-molecules and natural products such as HDACi are described in terms of cancer therapy and chemoprevention. Furthermore, structural considerations are included to improve the HDACi selectivity and combinatory potential with other specific targeting agents in bifunctional inhibitors and proteolysis targeting chimeras. Additionally, clinical trials that combine HDACi with current therapies are discussed, which may open new avenues in terms of the feasibility of HDACi’s future clinical applications in precision cancer therapies.
T2  - Pharmaceutics
T1  - Targeting Histone Deacetylases: Opportunities for Cancer Treatment and Chemoprevention
IS  - 1
SP  - 209
VL  - 14
DO  - 10.3390/pharmaceutics14010209
ER  - 

@article{
author = "Ružić, Dušan and Đoković, Nemanja and Srdić-Rajić, Tatjana and Echeverria, Cesar and Nikolić, Katarina and Santibanez, Juan F.",
year = "2022",
abstract = "The dysregulation of gene expression is a critical event involved in all steps of tumorigenesis. Aberrant histone and non-histone acetylation modifications of gene expression due to the abnormal activation of histone deacetylases (HDAC) have been reported in hematologic and solid types of cancer. In this sense, the cancer-associated epigenetic alterations are promising targets for anticancer therapy and chemoprevention. HDAC inhibitors (HDACi) induce histone hyperacetylation within target proteins, altering cell cycle and proliferation, cell differentiation, and the regulation of cell death programs. Over the last three decades, an increasing number of synthetic and naturally derived compounds, such as dietary-derived products, have been demonstrated to act as HDACi and have provided biological and molecular insights with regard to the role of HDAC in cancer. The first part of this review is focused on the biological roles of the Zinc-dependent HDAC family in malignant diseases. Accordingly, the small-molecules and natural products such as HDACi are described in terms of cancer therapy and chemoprevention. Furthermore, structural considerations are included to improve the HDACi selectivity and combinatory potential with other specific targeting agents in bifunctional inhibitors and proteolysis targeting chimeras. Additionally, clinical trials that combine HDACi with current therapies are discussed, which may open new avenues in terms of the feasibility of HDACi’s future clinical applications in precision cancer therapies.",
journal = "Pharmaceutics",
title = "Targeting Histone Deacetylases: Opportunities for Cancer Treatment and Chemoprevention",
number = "1",
pages = "209",
volume = "14",
doi = "10.3390/pharmaceutics14010209"
}

Ružić, D., Đoković, N., Srdić-Rajić, T., Echeverria, C., Nikolić, K.,& Santibanez, J. F.. (2022). Targeting Histone Deacetylases: Opportunities for Cancer Treatment and Chemoprevention. in Pharmaceutics, 14(1), 209.
https://doi.org/10.3390/pharmaceutics14010209

Ružić D, Đoković N, Srdić-Rajić T, Echeverria C, Nikolić K, Santibanez JF. Targeting Histone Deacetylases: Opportunities for Cancer Treatment and Chemoprevention. in Pharmaceutics. 2022;14(1):209.
doi:10.3390/pharmaceutics14010209 .

Ružić, Dušan, Đoković, Nemanja, Srdić-Rajić, Tatjana, Echeverria, Cesar, Nikolić, Katarina, Santibanez, Juan F., "Targeting Histone Deacetylases: Opportunities for Cancer Treatment and Chemoprevention" in Pharmaceutics, 14, no. 1 (2022):209,
https://doi.org/10.3390/pharmaceutics14010209 . .

TY  - JOUR
AU  - Echeverria, Cesar
AU  - Eltit, Felipe
AU  - Santibanez, Juan F.
AU  - Gatica, Sebastian
AU  - Cabello-Verrugio, Claudio
AU  - Simon, Felipe
PY  - 2020
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1034
AB  - In recent years, the vascular endothelium has gained attention as a key player in the initiation and development of pregnancy disorders. Endothelium acts as an endocrine organ that preserves the homeostatic balance by responding to changes in metabolic status. However, in metabolic disorders, endothelial cells adopt a dysfunctional function, losing their normal responsiveness. During pregnancy, several metabolic changes occur, in which endothelial function decisively participates. Similarly, when pregnancy metabolic disorders occur, endothelial dysfunction plays a key role in pathogenesis. This review outlines the main findings regarding endothelial dysfunction in three main metabolic pathological conditions observed during pregnancy: gestational diabetes, hypertensive disorders, and obesity and hyperlipidemia. Organ, histological and cellular characteristics were thoroughly described. Also, we focused in discussing the underlying molecular mechanisms involved in the cellular signaling pathways that mediate responses in these pathological conditions.
PB  - Elsevier, Amsterdam
T2  - Biochimica et Biophysica Acta-Molecular Basis of Disease
T1  - Endothelial dysfunction in pregnancy metabolic disorders
IS  - 2
SP  - 165414
VL  - 1866
DO  - 10.1016/j.bbadis.2019.02.009
ER  - 

@article{
author = "Echeverria, Cesar and Eltit, Felipe and Santibanez, Juan F. and Gatica, Sebastian and Cabello-Verrugio, Claudio and Simon, Felipe",
year = "2020",
abstract = "In recent years, the vascular endothelium has gained attention as a key player in the initiation and development of pregnancy disorders. Endothelium acts as an endocrine organ that preserves the homeostatic balance by responding to changes in metabolic status. However, in metabolic disorders, endothelial cells adopt a dysfunctional function, losing their normal responsiveness. During pregnancy, several metabolic changes occur, in which endothelial function decisively participates. Similarly, when pregnancy metabolic disorders occur, endothelial dysfunction plays a key role in pathogenesis. This review outlines the main findings regarding endothelial dysfunction in three main metabolic pathological conditions observed during pregnancy: gestational diabetes, hypertensive disorders, and obesity and hyperlipidemia. Organ, histological and cellular characteristics were thoroughly described. Also, we focused in discussing the underlying molecular mechanisms involved in the cellular signaling pathways that mediate responses in these pathological conditions.",
publisher = "Elsevier, Amsterdam",
journal = "Biochimica et Biophysica Acta-Molecular Basis of Disease",
title = "Endothelial dysfunction in pregnancy metabolic disorders",
number = "2",
pages = "165414",
volume = "1866",
doi = "10.1016/j.bbadis.2019.02.009"
}

Echeverria, C., Eltit, F., Santibanez, J. F., Gatica, S., Cabello-Verrugio, C.,& Simon, F.. (2020). Endothelial dysfunction in pregnancy metabolic disorders. in Biochimica et Biophysica Acta-Molecular Basis of Disease
Elsevier, Amsterdam., 1866(2), 165414.
https://doi.org/10.1016/j.bbadis.2019.02.009

Echeverria C, Eltit F, Santibanez JF, Gatica S, Cabello-Verrugio C, Simon F. Endothelial dysfunction in pregnancy metabolic disorders. in Biochimica et Biophysica Acta-Molecular Basis of Disease. 2020;1866(2):165414.
doi:10.1016/j.bbadis.2019.02.009 .

Echeverria, Cesar, Eltit, Felipe, Santibanez, Juan F., Gatica, Sebastian, Cabello-Verrugio, Claudio, Simon, Felipe, "Endothelial dysfunction in pregnancy metabolic disorders" in Biochimica et Biophysica Acta-Molecular Basis of Disease, 1866, no. 2 (2020):165414,
https://doi.org/10.1016/j.bbadis.2019.02.009 . .