TY  - JOUR
AU  - Međaković, Jelena
AU  - Čivljak, Antonia
AU  - Zorčec, Tatjana
AU  - Vučić, Vesna
AU  - Ristić-Medić, Danijela
AU  - Veselinović, Aleksandra
AU  - Čivljak, Marta
AU  - Puljak, Livia
PY  - 2024
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1487
AB  - Background: Parents/caregivers of children with developmental disabilities (CDD) have a wide range of support needs and there are various interventions available. Support, challenges, and needs among parents/caregivers of CDD likely vary in different geographical settings. This study aimed to analyze the perceptions of support, challenges, and needs among parents/caregivers of CDD in Croatia, North Macedonia, and Serbia. Methods: We conducted a cross-sectional study in March-April 2023 within the Erasmus + SynergyEd project. The eligible participants were parents and caregivers of CDD in Croatia, North Macedonia, and Serbia, who filled out a modified Caregiver Needs Survey online. Results: Among 953 participants, 542 (57%) were from Croatia, 205 (21%) were from North Macedonia and 206 (22%) were from Serbia. The most common diagnosis of participants’ children was autism spectrum disorder (26%). The child most often received the first diagnosis at the median of 2 years, diagnosed by a team of professionals. More than half (58%) of children attended preschool and public school, while 22% did not attend any schooling. Additional support from the state/city/county was received by 66% of CDD. Most participants declared not participating in association/organization for family support. Participants mostly (68%) used experts who work with the child as a source of information about their child’s condition, followed by the Internet (53%). In the last 12 months, 60% of participants had difficulties with the availability of services in their area or problems getting appointments. The biggest problem in getting support was ensuring the child’s basic rights were protected. Participants stated that ensuring greater rights for CDD was the greatest need for their families. Conclusion: Parents/caregivers of CDD in Croatia, North Macedonia, and Serbia faced multiple challenges, but most of them were satisfied with the services provided to their children. Future efforts to develop policies and services related to CDD should consider the opinions of their parents/caregivers and disparities in access to services.
PB  - Springer Nature
T2  - BMC Pediatrics
T1  - Perceptions on support, challenges and needs among parents and caregivers of children with developmental disabilities in Croatia, North Macedonia and Serbia: a cross-sectional study
IS  - 1
SP  - 297
VL  - 24
DO  - 10.1186/s12887-024-04770-7
ER  - 

@article{
author = "Međaković, Jelena and Čivljak, Antonia and Zorčec, Tatjana and Vučić, Vesna and Ristić-Medić, Danijela and Veselinović, Aleksandra and Čivljak, Marta and Puljak, Livia",
year = "2024",
abstract = "Background: Parents/caregivers of children with developmental disabilities (CDD) have a wide range of support needs and there are various interventions available. Support, challenges, and needs among parents/caregivers of CDD likely vary in different geographical settings. This study aimed to analyze the perceptions of support, challenges, and needs among parents/caregivers of CDD in Croatia, North Macedonia, and Serbia. Methods: We conducted a cross-sectional study in March-April 2023 within the Erasmus + SynergyEd project. The eligible participants were parents and caregivers of CDD in Croatia, North Macedonia, and Serbia, who filled out a modified Caregiver Needs Survey online. Results: Among 953 participants, 542 (57%) were from Croatia, 205 (21%) were from North Macedonia and 206 (22%) were from Serbia. The most common diagnosis of participants’ children was autism spectrum disorder (26%). The child most often received the first diagnosis at the median of 2 years, diagnosed by a team of professionals. More than half (58%) of children attended preschool and public school, while 22% did not attend any schooling. Additional support from the state/city/county was received by 66% of CDD. Most participants declared not participating in association/organization for family support. Participants mostly (68%) used experts who work with the child as a source of information about their child’s condition, followed by the Internet (53%). In the last 12 months, 60% of participants had difficulties with the availability of services in their area or problems getting appointments. The biggest problem in getting support was ensuring the child’s basic rights were protected. Participants stated that ensuring greater rights for CDD was the greatest need for their families. Conclusion: Parents/caregivers of CDD in Croatia, North Macedonia, and Serbia faced multiple challenges, but most of them were satisfied with the services provided to their children. Future efforts to develop policies and services related to CDD should consider the opinions of their parents/caregivers and disparities in access to services.",
publisher = "Springer Nature",
journal = "BMC Pediatrics",
title = "Perceptions on support, challenges and needs among parents and caregivers of children with developmental disabilities in Croatia, North Macedonia and Serbia: a cross-sectional study",
number = "1",
pages = "297",
volume = "24",
doi = "10.1186/s12887-024-04770-7"
}

Međaković, J., Čivljak, A., Zorčec, T., Vučić, V., Ristić-Medić, D., Veselinović, A., Čivljak, M.,& Puljak, L.. (2024). Perceptions on support, challenges and needs among parents and caregivers of children with developmental disabilities in Croatia, North Macedonia and Serbia: a cross-sectional study. in BMC Pediatrics
Springer Nature., 24(1), 297.
https://doi.org/10.1186/s12887-024-04770-7

Međaković J, Čivljak A, Zorčec T, Vučić V, Ristić-Medić D, Veselinović A, Čivljak M, Puljak L. Perceptions on support, challenges and needs among parents and caregivers of children with developmental disabilities in Croatia, North Macedonia and Serbia: a cross-sectional study. in BMC Pediatrics. 2024;24(1):297.
doi:10.1186/s12887-024-04770-7 .

Međaković, Jelena, Čivljak, Antonia, Zorčec, Tatjana, Vučić, Vesna, Ristić-Medić, Danijela, Veselinović, Aleksandra, Čivljak, Marta, Puljak, Livia, "Perceptions on support, challenges and needs among parents and caregivers of children with developmental disabilities in Croatia, North Macedonia and Serbia: a cross-sectional study" in BMC Pediatrics, 24, no. 1 (2024):297,
https://doi.org/10.1186/s12887-024-04770-7 . .

TY  - JOUR
AU  - Paunović, Marija
AU  - Milošević, Maja
AU  - Mitrović-Ajtić, Olivera
AU  - Veličković, Nataša
AU  - Mićić, Bojana
AU  - Nedić, Olgica
AU  - Todorović, Vanja
AU  - Vučić, Vesna
AU  - Petrović, Snježana
PY  - 2024
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1476
AB  - Diets high in fat and sugar lead to metabolic syndrome (MetS) and related chronic diseases. We investigated the effects of commercially available, cold-pressed polyphenol-rich black currant (BC) and cornelian cherry (CC) juices on the prevention of MetS in Wistar rats induced by a 10-weeks high-fat high-fructose (HFF) diet. Juice consumption, either BC or CC, with a HFF diet resulted in lower serum triglycerides compared to only the HFF consumption. Both juices also mitigated the effects of HFF on the liver, pancreas, and adipose tissue, by preserving liver and pancreas histomorphology and reducing visceral fat and adipocyte size. Furthermore, supplementation with both juices reduced glucagon and up-regulated insulin expression in the pancreas of the rats on the HFF diet, whereas the BC also showed improved glucose regulation. BC juice also reduced the expression of IL-6 and hepatic inflammation compared to the group only on HFF diet. Both juices, especially BC, could be a convenient solution for the prevention of MetS in humans.
PB  - Elsevier
T2  - Heliyon
T1  - Polyphenol-rich black currant and cornelian cherry juices ameliorate metabolic syndrome induced by a high-fat high-fructose diet in Wistar rats
IS  - 7
SP  - e27709
VL  - 10
DO  - 10.1016/j.heliyon.2024.e27709
ER  - 

@article{
author = "Paunović, Marija and Milošević, Maja and Mitrović-Ajtić, Olivera and Veličković, Nataša and Mićić, Bojana and Nedić, Olgica and Todorović, Vanja and Vučić, Vesna and Petrović, Snježana",
year = "2024",
abstract = "Diets high in fat and sugar lead to metabolic syndrome (MetS) and related chronic diseases. We investigated the effects of commercially available, cold-pressed polyphenol-rich black currant (BC) and cornelian cherry (CC) juices on the prevention of MetS in Wistar rats induced by a 10-weeks high-fat high-fructose (HFF) diet. Juice consumption, either BC or CC, with a HFF diet resulted in lower serum triglycerides compared to only the HFF consumption. Both juices also mitigated the effects of HFF on the liver, pancreas, and adipose tissue, by preserving liver and pancreas histomorphology and reducing visceral fat and adipocyte size. Furthermore, supplementation with both juices reduced glucagon and up-regulated insulin expression in the pancreas of the rats on the HFF diet, whereas the BC also showed improved glucose regulation. BC juice also reduced the expression of IL-6 and hepatic inflammation compared to the group only on HFF diet. Both juices, especially BC, could be a convenient solution for the prevention of MetS in humans.",
publisher = "Elsevier",
journal = "Heliyon",
title = "Polyphenol-rich black currant and cornelian cherry juices ameliorate metabolic syndrome induced by a high-fat high-fructose diet in Wistar rats",
number = "7",
pages = "e27709",
volume = "10",
doi = "10.1016/j.heliyon.2024.e27709"
}

Paunović, M., Milošević, M., Mitrović-Ajtić, O., Veličković, N., Mićić, B., Nedić, O., Todorović, V., Vučić, V.,& Petrović, S.. (2024). Polyphenol-rich black currant and cornelian cherry juices ameliorate metabolic syndrome induced by a high-fat high-fructose diet in Wistar rats. in Heliyon
Elsevier., 10(7), e27709.
https://doi.org/10.1016/j.heliyon.2024.e27709

Paunović M, Milošević M, Mitrović-Ajtić O, Veličković N, Mićić B, Nedić O, Todorović V, Vučić V, Petrović S. Polyphenol-rich black currant and cornelian cherry juices ameliorate metabolic syndrome induced by a high-fat high-fructose diet in Wistar rats. in Heliyon. 2024;10(7):e27709.
doi:10.1016/j.heliyon.2024.e27709 .

Paunović, Marija, Milošević, Maja, Mitrović-Ajtić, Olivera, Veličković, Nataša, Mićić, Bojana, Nedić, Olgica, Todorović, Vanja, Vučić, Vesna, Petrović, Snježana, "Polyphenol-rich black currant and cornelian cherry juices ameliorate metabolic syndrome induced by a high-fat high-fructose diet in Wistar rats" in Heliyon, 10, no. 7 (2024):e27709,
https://doi.org/10.1016/j.heliyon.2024.e27709 . .

TY  - JOUR
AU  - Paunović, Marija
AU  - Ristić-Medić, Danijela
AU  - Arsić, Aleksandra
AU  - Petrović, Snježana
AU  - Krstić, Predrag
AU  - Kojadinović, Milica
AU  - Vučić, Vesna
PY  - 2024
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1482
AB  - Background/Aim. Since the coronavirus disease 2019 (COVID-19) pandemic led to a strict lockdown in Serbia, the population has experienced drastic lifestyle changes. Physical distancing, self-isolation, limited availability of essential food products, and the stress related to the availability of therapy during the pandemic particularly affected the lives of vulnerable groups, such as breast cancer (BrC) patients. The aim of this study was to examine the changes in eating behaviors and physical activity of postmenopausal BrC patients on adjuvant hormonal therapy under the COVID-19 lockdown conditions. Methods. This observational retrospective pre-post cohort study included 32 women treated with aromatase inhibitors (AIs) who responded to telephone interviews using a structured questionnaire. The questionnaire aims to collect data on eating habits (intake of certain foods on a daily/weekly basis, as well as changes in the usual choice of food), intake of supplements, changes in weight, and physical activity before and during the lockdown. Results. The results showed that, due to problems in obtaining groceries, the patients cooked and consumed homemade sweets and fruit more often (47% of the respondents), while fewer (31%) consumed fresh fish. Nearly 41% of patients reported increased food intake, and 88% reported decreased physical activity, which led to an increase in body weight in as many as 47% of subjects. The intake of supplements was doubled. Conclusion. The COVID-19 lockdown with home confinement exacerbated health risks and affected dietary patterns and physical activity, which may have had a negative impact on the long-term health of BrC patients treated with AIs.
PB  - Military Medical Academy, INI
T2  - Vojnosanitetski pregled
T2  - Vojnosanitetski pregled
T1  - Eating behaviors and physical activity during the COVID-19 pandemic lockdown: Experiences of breast cancer patients on adjuvant hormonal therapy
EP  - xx
IS  - 00
SP  - xx
DO  - 10.2298/VSP231122020P
ER  - 

@article{
author = "Paunović, Marija and Ristić-Medić, Danijela and Arsić, Aleksandra and Petrović, Snježana and Krstić, Predrag and Kojadinović, Milica and Vučić, Vesna",
year = "2024",
abstract = "Background/Aim. Since the coronavirus disease 2019 (COVID-19) pandemic led to a strict lockdown in Serbia, the population has experienced drastic lifestyle changes. Physical distancing, self-isolation, limited availability of essential food products, and the stress related to the availability of therapy during the pandemic particularly affected the lives of vulnerable groups, such as breast cancer (BrC) patients. The aim of this study was to examine the changes in eating behaviors and physical activity of postmenopausal BrC patients on adjuvant hormonal therapy under the COVID-19 lockdown conditions. Methods. This observational retrospective pre-post cohort study included 32 women treated with aromatase inhibitors (AIs) who responded to telephone interviews using a structured questionnaire. The questionnaire aims to collect data on eating habits (intake of certain foods on a daily/weekly basis, as well as changes in the usual choice of food), intake of supplements, changes in weight, and physical activity before and during the lockdown. Results. The results showed that, due to problems in obtaining groceries, the patients cooked and consumed homemade sweets and fruit more often (47% of the respondents), while fewer (31%) consumed fresh fish. Nearly 41% of patients reported increased food intake, and 88% reported decreased physical activity, which led to an increase in body weight in as many as 47% of subjects. The intake of supplements was doubled. Conclusion. The COVID-19 lockdown with home confinement exacerbated health risks and affected dietary patterns and physical activity, which may have had a negative impact on the long-term health of BrC patients treated with AIs.",
publisher = "Military Medical Academy, INI",
journal = "Vojnosanitetski pregled, Vojnosanitetski pregled",
title = "Eating behaviors and physical activity during the COVID-19 pandemic lockdown: Experiences of breast cancer patients on adjuvant hormonal therapy",
pages = "xx-xx",
number = "00",
doi = "10.2298/VSP231122020P"
}

Paunović, M., Ristić-Medić, D., Arsić, A., Petrović, S., Krstić, P., Kojadinović, M.,& Vučić, V.. (2024). Eating behaviors and physical activity during the COVID-19 pandemic lockdown: Experiences of breast cancer patients on adjuvant hormonal therapy. in Vojnosanitetski pregled
Military Medical Academy, INI.(00), xx-xx.
https://doi.org/10.2298/VSP231122020P

Paunović M, Ristić-Medić D, Arsić A, Petrović S, Krstić P, Kojadinović M, Vučić V. Eating behaviors and physical activity during the COVID-19 pandemic lockdown: Experiences of breast cancer patients on adjuvant hormonal therapy. in Vojnosanitetski pregled. 2024;(00):xx-xx.
doi:10.2298/VSP231122020P .

Paunović, Marija, Ristić-Medić, Danijela, Arsić, Aleksandra, Petrović, Snježana, Krstić, Predrag, Kojadinović, Milica, Vučić, Vesna, "Eating behaviors and physical activity during the COVID-19 pandemic lockdown: Experiences of breast cancer patients on adjuvant hormonal therapy" in Vojnosanitetski pregled, no. 00 (2024):xx-xx,
https://doi.org/10.2298/VSP231122020P . .

TY  - CONF
AU  - Paunović, Marija
AU  - Milošević, Maja
AU  - Mitrović-Ajtić, Olivera
AU  - Todorović, Vanja
AU  - Petrović, Snježana
AU  - Vučić, Vesna
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1424
PB  - Niš: Punta
C3  - Cardionephrology : 6th International Congress of Cardionephrology - KARNEF 2023, May 29-30, 2023, Pirot, Serbia
T1  - Upotreba sokova bogatih polifenolima kao potencijalna prevencija razvoja metaboličkog sindroma i poremećaja vezanih za gojaznost
EP  - 161
SP  - 160
UR  - https://hdl.handle.net/21.15107/rcub_rimi_1424
ER  - 

@conference{
author = "Paunović, Marija and Milošević, Maja and Mitrović-Ajtić, Olivera and Todorović, Vanja and Petrović, Snježana and Vučić, Vesna",
year = "2023",
publisher = "Niš: Punta",
journal = "Cardionephrology : 6th International Congress of Cardionephrology - KARNEF 2023, May 29-30, 2023, Pirot, Serbia",
title = "Upotreba sokova bogatih polifenolima kao potencijalna prevencija razvoja metaboličkog sindroma i poremećaja vezanih za gojaznost",
pages = "161-160",
url = "https://hdl.handle.net/21.15107/rcub_rimi_1424"
}

Paunović, M., Milošević, M., Mitrović-Ajtić, O., Todorović, V., Petrović, S.,& Vučić, V.. (2023). Upotreba sokova bogatih polifenolima kao potencijalna prevencija razvoja metaboličkog sindroma i poremećaja vezanih za gojaznost. in Cardionephrology : 6th International Congress of Cardionephrology - KARNEF 2023, May 29-30, 2023, Pirot, Serbia
Niš: Punta., 160-161.
https://hdl.handle.net/21.15107/rcub_rimi_1424

Paunović M, Milošević M, Mitrović-Ajtić O, Todorović V, Petrović S, Vučić V. Upotreba sokova bogatih polifenolima kao potencijalna prevencija razvoja metaboličkog sindroma i poremećaja vezanih za gojaznost. in Cardionephrology : 6th International Congress of Cardionephrology - KARNEF 2023, May 29-30, 2023, Pirot, Serbia. 2023;:160-161.
https://hdl.handle.net/21.15107/rcub_rimi_1424 .

Paunović, Marija, Milošević, Maja, Mitrović-Ajtić, Olivera, Todorović, Vanja, Petrović, Snježana, Vučić, Vesna, "Upotreba sokova bogatih polifenolima kao potencijalna prevencija razvoja metaboličkog sindroma i poremećaja vezanih za gojaznost" in Cardionephrology : 6th International Congress of Cardionephrology - KARNEF 2023, May 29-30, 2023, Pirot, Serbia (2023):160-161,
https://hdl.handle.net/21.15107/rcub_rimi_1424 .

TY  - CONF
AU  - Paunović, Marija
AU  - Milošević, Maja
AU  - Mitrović-Ajtić, Olivera
AU  - Todorović, Vanja
AU  - Petrović, Snježana
AU  - Vučić, Vesna
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1442
PB  - Niš: Punta
C3  - Cardionephrology : 6th International Congress of Cardionephrology - KARNEF 2023, May 29-30, 2023, Pirot, Serbia - Abstract Book
T1  - Polyphenol-Rich Juices as a Potential Solution for Preventing Metabolic Syndrome and Related Obesity Disorders
EP  - 161
SP  - 160
UR  - https://hdl.handle.net/21.15107/rcub_rimi_1442
ER  - 

@conference{
author = "Paunović, Marija and Milošević, Maja and Mitrović-Ajtić, Olivera and Todorović, Vanja and Petrović, Snježana and Vučić, Vesna",
year = "2023",
publisher = "Niš: Punta",
journal = "Cardionephrology : 6th International Congress of Cardionephrology - KARNEF 2023, May 29-30, 2023, Pirot, Serbia - Abstract Book",
title = "Polyphenol-Rich Juices as a Potential Solution for Preventing Metabolic Syndrome and Related Obesity Disorders",
pages = "161-160",
url = "https://hdl.handle.net/21.15107/rcub_rimi_1442"
}

Paunović, M., Milošević, M., Mitrović-Ajtić, O., Todorović, V., Petrović, S.,& Vučić, V.. (2023). Polyphenol-Rich Juices as a Potential Solution for Preventing Metabolic Syndrome and Related Obesity Disorders. in Cardionephrology : 6th International Congress of Cardionephrology - KARNEF 2023, May 29-30, 2023, Pirot, Serbia - Abstract Book
Niš: Punta., 160-161.
https://hdl.handle.net/21.15107/rcub_rimi_1442

Paunović M, Milošević M, Mitrović-Ajtić O, Todorović V, Petrović S, Vučić V. Polyphenol-Rich Juices as a Potential Solution for Preventing Metabolic Syndrome and Related Obesity Disorders. in Cardionephrology : 6th International Congress of Cardionephrology - KARNEF 2023, May 29-30, 2023, Pirot, Serbia - Abstract Book. 2023;:160-161.
https://hdl.handle.net/21.15107/rcub_rimi_1442 .

Paunović, Marija, Milošević, Maja, Mitrović-Ajtić, Olivera, Todorović, Vanja, Petrović, Snježana, Vučić, Vesna, "Polyphenol-Rich Juices as a Potential Solution for Preventing Metabolic Syndrome and Related Obesity Disorders" in Cardionephrology : 6th International Congress of Cardionephrology - KARNEF 2023, May 29-30, 2023, Pirot, Serbia - Abstract Book (2023):160-161,
https://hdl.handle.net/21.15107/rcub_rimi_1442 .

TY  - JOUR
AU  - Paunović, Marija
AU  - Kotur-Stevuljević, Jelena
AU  - Arsić, Aleksandra
AU  - Milošević, Maja
AU  - Todorović, Vanja
AU  - Guzonjić, Azra
AU  - Vučić, Vesna M.
AU  - Petrović, Snježana
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1303
AB  - A Western-style diet, rich in fat and simple sugars, is the main risk factor for a significant number of chronic diseases and disorders, as well as for a progression of metabolic syndrome (MetS). One of the key mechanisms involved in MetS development is increased oxidative stress caused by the accumulation of body fat. Some dietary polyphenols have shown a protective role in preventing oxidative-stress-induced damage. We investigated the difference in the oxidative response of plasma, liver, and visceral adipose tissue in rats fed with a high-fat high-fructose (HFF) diet for ten weeks, and the effectiveness of polyphenol-rich juices (black currant (BC) and cornelian cherry (CC)) in HFF-diet-induced oxidative stress prevention. The most prominent impact of the HFF diet on redox parameters was recorded in the liver, whereas adipose tissue showed the most potent protection mechanisms against oxidative stress. Consumption of both juices decreased advanced oxidation protein product (AOPP) level in plasma, increased paraoxonase1 (PON1) activity in the liver, and significantly decreased total oxidative status (TOS) in adipose tissue. BC exerted stronger antioxidative potential than CC and decreased the superoxide anion radical (O2•−) level in the liver. It also reduced TOS, total antioxidative status (TAS), and malondialdehyde (MDA) concentration in adipose tissue. The multiple linear regression analysis has shown that the best predictors of MetS development, estimated through the increase in visceral adiposity, were superoxide dismutase (SOD), AOPP, TOS, and TAS. The consumption of polyphenol-rich juices may provide a convenient approach for the systemic reduction of oxidative stress parameters.
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Antioxidants
T1  - Antioxidative Effects of Black Currant and Cornelian Cherry Juices in Different Tissues of an Experimental Model of Metabolic Syndrome in Rats
IS  - 6
SP  - 1148
VL  - 12
DO  - 10.3390/antiox12061148
ER  - 

@article{
author = "Paunović, Marija and Kotur-Stevuljević, Jelena and Arsić, Aleksandra and Milošević, Maja and Todorović, Vanja and Guzonjić, Azra and Vučić, Vesna M. and Petrović, Snježana",
year = "2023",
abstract = "A Western-style diet, rich in fat and simple sugars, is the main risk factor for a significant number of chronic diseases and disorders, as well as for a progression of metabolic syndrome (MetS). One of the key mechanisms involved in MetS development is increased oxidative stress caused by the accumulation of body fat. Some dietary polyphenols have shown a protective role in preventing oxidative-stress-induced damage. We investigated the difference in the oxidative response of plasma, liver, and visceral adipose tissue in rats fed with a high-fat high-fructose (HFF) diet for ten weeks, and the effectiveness of polyphenol-rich juices (black currant (BC) and cornelian cherry (CC)) in HFF-diet-induced oxidative stress prevention. The most prominent impact of the HFF diet on redox parameters was recorded in the liver, whereas adipose tissue showed the most potent protection mechanisms against oxidative stress. Consumption of both juices decreased advanced oxidation protein product (AOPP) level in plasma, increased paraoxonase1 (PON1) activity in the liver, and significantly decreased total oxidative status (TOS) in adipose tissue. BC exerted stronger antioxidative potential than CC and decreased the superoxide anion radical (O2•−) level in the liver. It also reduced TOS, total antioxidative status (TAS), and malondialdehyde (MDA) concentration in adipose tissue. The multiple linear regression analysis has shown that the best predictors of MetS development, estimated through the increase in visceral adiposity, were superoxide dismutase (SOD), AOPP, TOS, and TAS. The consumption of polyphenol-rich juices may provide a convenient approach for the systemic reduction of oxidative stress parameters.",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Antioxidants",
title = "Antioxidative Effects of Black Currant and Cornelian Cherry Juices in Different Tissues of an Experimental Model of Metabolic Syndrome in Rats",
number = "6",
pages = "1148",
volume = "12",
doi = "10.3390/antiox12061148"
}

Paunović, M., Kotur-Stevuljević, J., Arsić, A., Milošević, M., Todorović, V., Guzonjić, A., Vučić, V. M.,& Petrović, S.. (2023). Antioxidative Effects of Black Currant and Cornelian Cherry Juices in Different Tissues of an Experimental Model of Metabolic Syndrome in Rats. in Antioxidants
Multidisciplinary Digital Publishing Institute (MDPI)., 12(6), 1148.
https://doi.org/10.3390/antiox12061148

Paunović M, Kotur-Stevuljević J, Arsić A, Milošević M, Todorović V, Guzonjić A, Vučić VM, Petrović S. Antioxidative Effects of Black Currant and Cornelian Cherry Juices in Different Tissues of an Experimental Model of Metabolic Syndrome in Rats. in Antioxidants. 2023;12(6):1148.
doi:10.3390/antiox12061148 .

Paunović, Marija, Kotur-Stevuljević, Jelena, Arsić, Aleksandra, Milošević, Maja, Todorović, Vanja, Guzonjić, Azra, Vučić, Vesna M., Petrović, Snježana, "Antioxidative Effects of Black Currant and Cornelian Cherry Juices in Different Tissues of an Experimental Model of Metabolic Syndrome in Rats" in Antioxidants, 12, no. 6 (2023):1148,
https://doi.org/10.3390/antiox12061148 . .

TY  - JOUR
AU  - Vučić, Vesna M.
AU  - Ristić-Medić, Danijela
AU  - Arsić, Aleksandra
AU  - Petrović, Snježana
AU  - Paunović, Marija
AU  - Vasiljević, Nađa
AU  - Ilich, Jasminka Z.
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1308
AB  - Osteosarcopenic adiposity (OSA) syndrome denotes the confluence of bone, muscle, and adipose tissue deterioration. Being a complex entity, numerous uncertainties about OSA still exist, despite the extensive research on the topic. Our objectives were to evaluate human studies addressing dietary intake/nutritional status and the quantity/types of physical activity related to OSA. The search in PubMed, Scopus, and Web of Science databases was conducted to examine relevant articles published from inception to the end of December 2022, utilizing the MeSH strings in the search strategy. Only studies published in English and conducted in humans (≥18 years) without chronic conditions (cancers, kidney/liver disease) or pregnancy were used. Book chapters, abstracts-only, and studies in which participants did not have all three body composition components measured to identify OSA or when body composition components could not be related to the independent/exposure variables were excluded. A total of n = 1020 articles were retrieved from all three databases and eight more from the reference lists. After the exclusion of duplicates and other unsuitable articles, n = 23 studies were evaluated. Among those, eleven were from epidemiological or cross-sectional studies relating nutrients/dietary intake or nutritional status with OSA. Another four examined the relationship between serum biomarkers (vitamin D and ferritin) with OSA, while eight articles presented the results of the interventional studies with resistance training. Overall, higher protein, calcium, potassium, and vitamins D and C intakes emerged as nutrients positively modifying OSA, along with a diet higher in fruits and low-fat dairy foods. Higher serum vitamin D and ferritin were respectively positively and negatively related to OSA. Resistance training was a safe intervention yielding several beneficial outcomes for the OSA syndrome in older women.
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Nutrients
T1  - Nutrition and Physical Activity as Modulators of Osteosarcopenic Adiposity: A Scoping Review and Recommendations for Future Research
IS  - 7
SP  - 1619
VL  - 15
DO  - 10.3390/nu15071619
ER  - 

@article{
author = "Vučić, Vesna M. and Ristić-Medić, Danijela and Arsić, Aleksandra and Petrović, Snježana and Paunović, Marija and Vasiljević, Nađa and Ilich, Jasminka Z.",
year = "2023",
abstract = "Osteosarcopenic adiposity (OSA) syndrome denotes the confluence of bone, muscle, and adipose tissue deterioration. Being a complex entity, numerous uncertainties about OSA still exist, despite the extensive research on the topic. Our objectives were to evaluate human studies addressing dietary intake/nutritional status and the quantity/types of physical activity related to OSA. The search in PubMed, Scopus, and Web of Science databases was conducted to examine relevant articles published from inception to the end of December 2022, utilizing the MeSH strings in the search strategy. Only studies published in English and conducted in humans (≥18 years) without chronic conditions (cancers, kidney/liver disease) or pregnancy were used. Book chapters, abstracts-only, and studies in which participants did not have all three body composition components measured to identify OSA or when body composition components could not be related to the independent/exposure variables were excluded. A total of n = 1020 articles were retrieved from all three databases and eight more from the reference lists. After the exclusion of duplicates and other unsuitable articles, n = 23 studies were evaluated. Among those, eleven were from epidemiological or cross-sectional studies relating nutrients/dietary intake or nutritional status with OSA. Another four examined the relationship between serum biomarkers (vitamin D and ferritin) with OSA, while eight articles presented the results of the interventional studies with resistance training. Overall, higher protein, calcium, potassium, and vitamins D and C intakes emerged as nutrients positively modifying OSA, along with a diet higher in fruits and low-fat dairy foods. Higher serum vitamin D and ferritin were respectively positively and negatively related to OSA. Resistance training was a safe intervention yielding several beneficial outcomes for the OSA syndrome in older women.",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Nutrients",
title = "Nutrition and Physical Activity as Modulators of Osteosarcopenic Adiposity: A Scoping Review and Recommendations for Future Research",
number = "7",
pages = "1619",
volume = "15",
doi = "10.3390/nu15071619"
}

Vučić, V. M., Ristić-Medić, D., Arsić, A., Petrović, S., Paunović, M., Vasiljević, N.,& Ilich, J. Z.. (2023). Nutrition and Physical Activity as Modulators of Osteosarcopenic Adiposity: A Scoping Review and Recommendations for Future Research. in Nutrients
Multidisciplinary Digital Publishing Institute (MDPI)., 15(7), 1619.
https://doi.org/10.3390/nu15071619

Vučić VM, Ristić-Medić D, Arsić A, Petrović S, Paunović M, Vasiljević N, Ilich JZ. Nutrition and Physical Activity as Modulators of Osteosarcopenic Adiposity: A Scoping Review and Recommendations for Future Research. in Nutrients. 2023;15(7):1619.
doi:10.3390/nu15071619 .

Vučić, Vesna M., Ristić-Medić, Danijela, Arsić, Aleksandra, Petrović, Snježana, Paunović, Marija, Vasiljević, Nađa, Ilich, Jasminka Z., "Nutrition and Physical Activity as Modulators of Osteosarcopenic Adiposity: A Scoping Review and Recommendations for Future Research" in Nutrients, 15, no. 7 (2023):1619,
https://doi.org/10.3390/nu15071619 . .

TY  - JOUR
AU  - Masnikosa, Romana
AU  - Pirić, David
AU  - Post, Julia Maria
AU  - Cvetković, Zorica
AU  - Petrović, Snježana
AU  - Paunović, Marija
AU  - Vučić, Vesna
AU  - Bindila, Laura
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1340
AB  - Lipidome dysregulation is a hallmark of cancer and inflammation. The global plasma lipidome and sub-lipidome of inflammatory pathways have not been reported in diffuse large B-cell lymphoma (DLBCL). In a pilot study of plasma lipid variation in female DLBCL patients and BMI-matched disease-free controls, we performed targeted lipidomics using LC-MRM to quantify lipid mediators of inflammation and immunity, and those known or hypothesised to be involved in cancer progression: sphingolipids, resolvin D1, arachidonic acid (AA)-derived oxylipins, such as hydroxyeicosatetraenoic acids (HETEs) and dihydroxyeicosatrienoic acids, along with their membrane structural precursors. We report on the role of the eicosanoids in the separation of DLBCL from controls, along with lysophosphatidylinositol LPI 20:4, implying notable changes in lipid metabolic and/or signalling pathways, particularly pertaining to AA lipoxygenase pathway and glycerophospholipid remodelling in the cell membrane. We suggest here the set of S1P, SM 36:1, SM 34:1 and PI 34:1 as DLBCL lipid signatures which could serve as a basis for the prospective validation in larger DLBCL cohorts. Additionally, untargeted lipidomics indicates a substantial change in the overall lipid metabolism in DLBCL. The plasma lipid profiling of DLBCL patients helps to better understand the specific lipid dysregulations and pathways in this cancer.
T2  - Cancers
T2  - Cancers
T1  - Disturbed Plasma Lipidomic Profiles in Females with Diffuse Large B-Cell Lymphoma: A Pilot Study
IS  - 14
SP  - 3653
VL  - 15
DO  - 10.3390/cancers15143653
ER  - 

@article{
author = "Masnikosa, Romana and Pirić, David and Post, Julia Maria and Cvetković, Zorica and Petrović, Snježana and Paunović, Marija and Vučić, Vesna and Bindila, Laura",
year = "2023",
abstract = "Lipidome dysregulation is a hallmark of cancer and inflammation. The global plasma lipidome and sub-lipidome of inflammatory pathways have not been reported in diffuse large B-cell lymphoma (DLBCL). In a pilot study of plasma lipid variation in female DLBCL patients and BMI-matched disease-free controls, we performed targeted lipidomics using LC-MRM to quantify lipid mediators of inflammation and immunity, and those known or hypothesised to be involved in cancer progression: sphingolipids, resolvin D1, arachidonic acid (AA)-derived oxylipins, such as hydroxyeicosatetraenoic acids (HETEs) and dihydroxyeicosatrienoic acids, along with their membrane structural precursors. We report on the role of the eicosanoids in the separation of DLBCL from controls, along with lysophosphatidylinositol LPI 20:4, implying notable changes in lipid metabolic and/or signalling pathways, particularly pertaining to AA lipoxygenase pathway and glycerophospholipid remodelling in the cell membrane. We suggest here the set of S1P, SM 36:1, SM 34:1 and PI 34:1 as DLBCL lipid signatures which could serve as a basis for the prospective validation in larger DLBCL cohorts. Additionally, untargeted lipidomics indicates a substantial change in the overall lipid metabolism in DLBCL. The plasma lipid profiling of DLBCL patients helps to better understand the specific lipid dysregulations and pathways in this cancer.",
journal = "Cancers, Cancers",
title = "Disturbed Plasma Lipidomic Profiles in Females with Diffuse Large B-Cell Lymphoma: A Pilot Study",
number = "14",
pages = "3653",
volume = "15",
doi = "10.3390/cancers15143653"
}

Masnikosa, R., Pirić, D., Post, J. M., Cvetković, Z., Petrović, S., Paunović, M., Vučić, V.,& Bindila, L.. (2023). Disturbed Plasma Lipidomic Profiles in Females with Diffuse Large B-Cell Lymphoma: A Pilot Study. in Cancers, 15(14), 3653.
https://doi.org/10.3390/cancers15143653

Masnikosa R, Pirić D, Post JM, Cvetković Z, Petrović S, Paunović M, Vučić V, Bindila L. Disturbed Plasma Lipidomic Profiles in Females with Diffuse Large B-Cell Lymphoma: A Pilot Study. in Cancers. 2023;15(14):3653.
doi:10.3390/cancers15143653 .

Masnikosa, Romana, Pirić, David, Post, Julia Maria, Cvetković, Zorica, Petrović, Snježana, Paunović, Marija, Vučić, Vesna, Bindila, Laura, "Disturbed Plasma Lipidomic Profiles in Females with Diffuse Large B-Cell Lymphoma: A Pilot Study" in Cancers, 15, no. 14 (2023):3653,
https://doi.org/10.3390/cancers15143653 . .

TY  - JOUR
AU  - Paunović, Marija
AU  - Vučić, Vesna
AU  - Milošević, Maja
AU  - Ristić-Medić, Danijela
AU  - Arsić, Aleksandra
AU  - Kojadinović, Milica
AU  - Petrović, Snježana
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1417
AB  - Metabolic syndrome (MetS) is a global public health challenge and one of the main risk factors for cardiovascular diseases. Its pandemic prevalence created a demand for developing a relevant model system for deep insight into the molecular basis of MetS. Animal models, especially Wistar rats, are commonly used for that purpose. However, there are no standardized protocols in terms of the diet, strain, or age of rats used for the development of MetS. Studies have mostly used a high-fat high-fructose (HFHF) diet in Wistar rats but have reported inconsistent results; thus the main aim of this study was to examine the effects of the HFHF diet on inducing MetS in Wistar rats. We used two different sub-strains of Wistar rats – Hannover and Kyoto – of two different age groups (8 weeks and 4 months). Animals were placed on a modified diet, standard chow diet enriched with 25% fat and 20% fructose. Following 8 weeks of treatment, all groups were tested for indicators of MetS and the treatment was extended to 16 weeks for groups that developed some of the required parameters. None of the tested groups developed MetS after 16 weeks of HFHF diet, suggesting that the HFHF diet is not sufficient to develop at least three out of five (visceral obesity, high fasting glucose, high triglyceride, low HDL-cholesterol, high blood pressure) needed parameters. Based on our results, the addition of some pharmacological agents (e.g., cholic acid) is necessary for establishing a rat model system of MetS.
PB  - University of Veterinary and Pharmaceutical Sciences
T2  - Acta Veterinaria Brno
T1  - Use of high-fat high-fructose diet for a model of metabolic syndrome in Wistar rats: challenges remain
EP  - 396
IS  - 4
SP  - 389
VL  - 92
DO  - 10.2754/avb202392040389
ER  - 

@article{
author = "Paunović, Marija and Vučić, Vesna and Milošević, Maja and Ristić-Medić, Danijela and Arsić, Aleksandra and Kojadinović, Milica and Petrović, Snježana",
year = "2023",
abstract = "Metabolic syndrome (MetS) is a global public health challenge and one of the main risk factors for cardiovascular diseases. Its pandemic prevalence created a demand for developing a relevant model system for deep insight into the molecular basis of MetS. Animal models, especially Wistar rats, are commonly used for that purpose. However, there are no standardized protocols in terms of the diet, strain, or age of rats used for the development of MetS. Studies have mostly used a high-fat high-fructose (HFHF) diet in Wistar rats but have reported inconsistent results; thus the main aim of this study was to examine the effects of the HFHF diet on inducing MetS in Wistar rats. We used two different sub-strains of Wistar rats – Hannover and Kyoto – of two different age groups (8 weeks and 4 months). Animals were placed on a modified diet, standard chow diet enriched with 25% fat and 20% fructose. Following 8 weeks of treatment, all groups were tested for indicators of MetS and the treatment was extended to 16 weeks for groups that developed some of the required parameters. None of the tested groups developed MetS after 16 weeks of HFHF diet, suggesting that the HFHF diet is not sufficient to develop at least three out of five (visceral obesity, high fasting glucose, high triglyceride, low HDL-cholesterol, high blood pressure) needed parameters. Based on our results, the addition of some pharmacological agents (e.g., cholic acid) is necessary for establishing a rat model system of MetS.",
publisher = "University of Veterinary and Pharmaceutical Sciences",
journal = "Acta Veterinaria Brno",
title = "Use of high-fat high-fructose diet for a model of metabolic syndrome in Wistar rats: challenges remain",
pages = "396-389",
number = "4",
volume = "92",
doi = "10.2754/avb202392040389"
}

Paunović, M., Vučić, V., Milošević, M., Ristić-Medić, D., Arsić, A., Kojadinović, M.,& Petrović, S.. (2023). Use of high-fat high-fructose diet for a model of metabolic syndrome in Wistar rats: challenges remain. in Acta Veterinaria Brno
University of Veterinary and Pharmaceutical Sciences., 92(4), 389-396.
https://doi.org/10.2754/avb202392040389

Paunović M, Vučić V, Milošević M, Ristić-Medić D, Arsić A, Kojadinović M, Petrović S. Use of high-fat high-fructose diet for a model of metabolic syndrome in Wistar rats: challenges remain. in Acta Veterinaria Brno. 2023;92(4):389-396.
doi:10.2754/avb202392040389 .

Paunović, Marija, Vučić, Vesna, Milošević, Maja, Ristić-Medić, Danijela, Arsić, Aleksandra, Kojadinović, Milica, Petrović, Snježana, "Use of high-fat high-fructose diet for a model of metabolic syndrome in Wistar rats: challenges remain" in Acta Veterinaria Brno, 92, no. 4 (2023):389-396,
https://doi.org/10.2754/avb202392040389 . .

TY  - JOUR
AU  - Arsić, Aleksandra
AU  - Krstić, Predrag
AU  - Paunović, Marija
AU  - Nedović, Jasmina
AU  - Jakovljević, Vladimir
AU  - Vučić, Vesna
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1313
AB  - Breast cancer is the most common malignant tumor and one of the leading causes of cancer-related death in women throughout the world. This study is a parallel, randomized, double-blind, controlled, 12-week supplementation trial, investigating the anti-inflammatory effects of dietary intake of fish oil and evening primrose oil (EPO), in patients with breast cancer undergoing chemotherapy. The primary outcomes were changes in the nutritional status and inflammatory cytokines of patients during the study. The secondary outcomes were changes in hematological and biochemical parameters and fatty acid profile. Of the 32 eligible patients, half of them is randomly assigned to a treatment arm with fish oil and EPO (n = 16), or a control arm (n = 16) with mineral oil as a placebo. The intervention group was taking 2 gel capsules of fish oil and 3 gel capsules of EPO (400 mg eicosapentaenoic acid, 600 mg docosahexaenoic acid, and 351 mg gamma-linolenic acid) fish oil and evening primrose oil for 12 weeks, during their chemotherapy. The control/placebo group was taking 5 gel capsules of 1g of mineral oil. One of the patients dropped out due to discontinuation of the treatment (in the placebo group) and two did not show up at the post-treatment measurements (in the intervention group), thus, 29 women completed the study. The results showed an increase in plasma levels of docosapentaenoic acid (22:5n-3), docosahexaenoic acid (22:6n-3), total n-3PUFA, vaccenic acid (18:1n-7), and a decrease in n-6/n-3 PUFA ratio in the intervention group. An increase in the plasma level of dihomo-gamma-linolenic acid (20:3n-6) was observed in the placebo group. There was no difference in plasma levels of interleukin (IL) IL-8, IL-10, and tumor necrosis factor-alpha, while the level of IL-6 decreased in both groups and was significantly lower in the intervention group at the end of the study. In conclusion, this supplementation improved the PUFA status and decreased the level of IL-6 in breast cancer patients undergoing chemotherapy. Consequently, this treatment may help reduce cancer complications resulting from impaired lipid metabolism and inflammation. ClinicalTrials.gov Identifier: NCT03516253. Date of registration 04/05/2018.
PB  - Springer Nature
T2  - Scientific Reports
T1  - Anti-inflammatory effect of combining fish oil and evening primrose oil supplementation on breast cancer patients undergoing chemotherapy: a randomized placebo-controlled trial
IS  - 1
SP  - 6449
VL  - 13
DO  - 10.1038/s41598-023-28411-8
ER  - 

@article{
author = "Arsić, Aleksandra and Krstić, Predrag and Paunović, Marija and Nedović, Jasmina and Jakovljević, Vladimir and Vučić, Vesna",
year = "2023",
abstract = "Breast cancer is the most common malignant tumor and one of the leading causes of cancer-related death in women throughout the world. This study is a parallel, randomized, double-blind, controlled, 12-week supplementation trial, investigating the anti-inflammatory effects of dietary intake of fish oil and evening primrose oil (EPO), in patients with breast cancer undergoing chemotherapy. The primary outcomes were changes in the nutritional status and inflammatory cytokines of patients during the study. The secondary outcomes were changes in hematological and biochemical parameters and fatty acid profile. Of the 32 eligible patients, half of them is randomly assigned to a treatment arm with fish oil and EPO (n = 16), or a control arm (n = 16) with mineral oil as a placebo. The intervention group was taking 2 gel capsules of fish oil and 3 gel capsules of EPO (400 mg eicosapentaenoic acid, 600 mg docosahexaenoic acid, and 351 mg gamma-linolenic acid) fish oil and evening primrose oil for 12 weeks, during their chemotherapy. The control/placebo group was taking 5 gel capsules of 1g of mineral oil. One of the patients dropped out due to discontinuation of the treatment (in the placebo group) and two did not show up at the post-treatment measurements (in the intervention group), thus, 29 women completed the study. The results showed an increase in plasma levels of docosapentaenoic acid (22:5n-3), docosahexaenoic acid (22:6n-3), total n-3PUFA, vaccenic acid (18:1n-7), and a decrease in n-6/n-3 PUFA ratio in the intervention group. An increase in the plasma level of dihomo-gamma-linolenic acid (20:3n-6) was observed in the placebo group. There was no difference in plasma levels of interleukin (IL) IL-8, IL-10, and tumor necrosis factor-alpha, while the level of IL-6 decreased in both groups and was significantly lower in the intervention group at the end of the study. In conclusion, this supplementation improved the PUFA status and decreased the level of IL-6 in breast cancer patients undergoing chemotherapy. Consequently, this treatment may help reduce cancer complications resulting from impaired lipid metabolism and inflammation. ClinicalTrials.gov Identifier: NCT03516253. Date of registration 04/05/2018.",
publisher = "Springer Nature",
journal = "Scientific Reports",
title = "Anti-inflammatory effect of combining fish oil and evening primrose oil supplementation on breast cancer patients undergoing chemotherapy: a randomized placebo-controlled trial",
number = "1",
pages = "6449",
volume = "13",
doi = "10.1038/s41598-023-28411-8"
}

Arsić, A., Krstić, P., Paunović, M., Nedović, J., Jakovljević, V.,& Vučić, V.. (2023). Anti-inflammatory effect of combining fish oil and evening primrose oil supplementation on breast cancer patients undergoing chemotherapy: a randomized placebo-controlled trial. in Scientific Reports
Springer Nature., 13(1), 6449.
https://doi.org/10.1038/s41598-023-28411-8

Arsić A, Krstić P, Paunović M, Nedović J, Jakovljević V, Vučić V. Anti-inflammatory effect of combining fish oil and evening primrose oil supplementation on breast cancer patients undergoing chemotherapy: a randomized placebo-controlled trial. in Scientific Reports. 2023;13(1):6449.
doi:10.1038/s41598-023-28411-8 .

Arsić, Aleksandra, Krstić, Predrag, Paunović, Marija, Nedović, Jasmina, Jakovljević, Vladimir, Vučić, Vesna, "Anti-inflammatory effect of combining fish oil and evening primrose oil supplementation on breast cancer patients undergoing chemotherapy: a randomized placebo-controlled trial" in Scientific Reports, 13, no. 1 (2023):6449,
https://doi.org/10.1038/s41598-023-28411-8 . .

TY  - CONF
AU  - Vučić, Vesna
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1435
PB  - Timisoara: "Victor Babes" University of medicine and pharmacy from Timisoara
C3  - 9th European Section Meeting of the International Academy of Cardiovascular Sciences, October 4th – 7th 2023, Timișoara, Romania - Programme & Abstract Book
T1  - Osteosarcopenic adiposity - Implications for cardiometabolic disorders
EP  - 41
SP  - 41
UR  - https://hdl.handle.net/21.15107/rcub_rimi_1435
ER  - 

@conference{
author = "Vučić, Vesna",
year = "2023",
publisher = "Timisoara: "Victor Babes" University of medicine and pharmacy from Timisoara",
journal = "9th European Section Meeting of the International Academy of Cardiovascular Sciences, October 4th – 7th 2023, Timișoara, Romania - Programme & Abstract Book",
title = "Osteosarcopenic adiposity - Implications for cardiometabolic disorders",
pages = "41-41",
url = "https://hdl.handle.net/21.15107/rcub_rimi_1435"
}

Vučić, V.. (2023). Osteosarcopenic adiposity - Implications for cardiometabolic disorders. in 9th European Section Meeting of the International Academy of Cardiovascular Sciences, October 4th – 7th 2023, Timișoara, Romania - Programme & Abstract Book
Timisoara: "Victor Babes" University of medicine and pharmacy from Timisoara., 41-41.
https://hdl.handle.net/21.15107/rcub_rimi_1435

Vučić V. Osteosarcopenic adiposity - Implications for cardiometabolic disorders. in 9th European Section Meeting of the International Academy of Cardiovascular Sciences, October 4th – 7th 2023, Timișoara, Romania - Programme & Abstract Book. 2023;:41-41.
https://hdl.handle.net/21.15107/rcub_rimi_1435 .

Vučić, Vesna, "Osteosarcopenic adiposity - Implications for cardiometabolic disorders" in 9th European Section Meeting of the International Academy of Cardiovascular Sciences, October 4th – 7th 2023, Timișoara, Romania - Programme & Abstract Book (2023):41-41,
https://hdl.handle.net/21.15107/rcub_rimi_1435 .

TY  - JOUR
AU  - Zelenović, Nevena
AU  - Kojadinović, Milica
AU  - Filipović, Lidija
AU  - Vučić, Vesna
AU  - Milčić, Miloš
AU  - Arsić, Aleksandra
AU  - Popović, Milica
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1309
AB  - Backgound/Objectives: Urolithins (UROs) are the metabolites derived from the gut microbial action on ellagitannins and ellagic acid-rich foods. Following their absorption in the intestine, UROs are transported through the systemic circulation to various tissues where they can express their biological function as antimicrobial, anti-inflammatory, and anticancer agents. In addition to blood plasma, where they can be found as glucuronide and sulfate conjugates, they are also found in urine. Therefore, the interactions of UROs with serum proteins are of great clinical interest. Methods: A powerful technique for examining these urolithin-serum protein interactions is fluorescence spectroscopy. Bovine serum albumin (BSA) is a particularly suitable model protein because it is readily available, affordable, and similar to human serum albumin. This work aimed to study the binding of UROs (urolithin A, UROA and urolithin B, UROB) and their glucuronide conjugates (UROAG and UROBG) to BSA by quenching the intrinsic fluorescence of protein. Results: The spectra obtained showed that the binding process is influenced by the polyphenol's structure and the conjugation process with the glucuronide. The calculated Stern Vollmer binding constants (Ksv): UROA and UROB Ksv were 59236 ± 5706 and 69653 ± 14922, respectively, while for UROAG and UROBG, these values were 15179 ± 2770 and 9462 ± 1955, respectively, which showed that the binding affinity decreased with glucuronidation. Molecular docking studies confirmed that all of the studied molecules will bind favorably to BSA. The preferential binding site for both UROs and UROGs is Sudlow I, while UROs will also bind to Sudlow II. URO-Gs can bind to BSA in the cleft region with lower binding scores than for the Sudlow I binding site. Conclusion: The aglycone's higher hydrophobicity increases the binding affinity to BSA, thus reducing its bioavailability in the blood.
PB  - SAGE
T2  - Natural Product Communications
T1  - Interactions of Different Urolithins With Bovine Serum Albumin
IS  - 5
VL  - 18
DO  - 10.1177/1934578X231169366
ER  - 

@article{
author = "Zelenović, Nevena and Kojadinović, Milica and Filipović, Lidija and Vučić, Vesna and Milčić, Miloš and Arsić, Aleksandra and Popović, Milica",
year = "2023",
abstract = "Backgound/Objectives: Urolithins (UROs) are the metabolites derived from the gut microbial action on ellagitannins and ellagic acid-rich foods. Following their absorption in the intestine, UROs are transported through the systemic circulation to various tissues where they can express their biological function as antimicrobial, anti-inflammatory, and anticancer agents. In addition to blood plasma, where they can be found as glucuronide and sulfate conjugates, they are also found in urine. Therefore, the interactions of UROs with serum proteins are of great clinical interest. Methods: A powerful technique for examining these urolithin-serum protein interactions is fluorescence spectroscopy. Bovine serum albumin (BSA) is a particularly suitable model protein because it is readily available, affordable, and similar to human serum albumin. This work aimed to study the binding of UROs (urolithin A, UROA and urolithin B, UROB) and their glucuronide conjugates (UROAG and UROBG) to BSA by quenching the intrinsic fluorescence of protein. Results: The spectra obtained showed that the binding process is influenced by the polyphenol's structure and the conjugation process with the glucuronide. The calculated Stern Vollmer binding constants (Ksv): UROA and UROB Ksv were 59236 ± 5706 and 69653 ± 14922, respectively, while for UROAG and UROBG, these values were 15179 ± 2770 and 9462 ± 1955, respectively, which showed that the binding affinity decreased with glucuronidation. Molecular docking studies confirmed that all of the studied molecules will bind favorably to BSA. The preferential binding site for both UROs and UROGs is Sudlow I, while UROs will also bind to Sudlow II. URO-Gs can bind to BSA in the cleft region with lower binding scores than for the Sudlow I binding site. Conclusion: The aglycone's higher hydrophobicity increases the binding affinity to BSA, thus reducing its bioavailability in the blood.",
publisher = "SAGE",
journal = "Natural Product Communications",
title = "Interactions of Different Urolithins With Bovine Serum Albumin",
number = "5",
volume = "18",
doi = "10.1177/1934578X231169366"
}

Zelenović, N., Kojadinović, M., Filipović, L., Vučić, V., Milčić, M., Arsić, A.,& Popović, M.. (2023). Interactions of Different Urolithins With Bovine Serum Albumin. in Natural Product Communications
SAGE., 18(5).
https://doi.org/10.1177/1934578X231169366

Zelenović N, Kojadinović M, Filipović L, Vučić V, Milčić M, Arsić A, Popović M. Interactions of Different Urolithins With Bovine Serum Albumin. in Natural Product Communications. 2023;18(5).
doi:10.1177/1934578X231169366 .

Zelenović, Nevena, Kojadinović, Milica, Filipović, Lidija, Vučić, Vesna, Milčić, Miloš, Arsić, Aleksandra, Popović, Milica, "Interactions of Different Urolithins With Bovine Serum Albumin" in Natural Product Communications, 18, no. 5 (2023),
https://doi.org/10.1177/1934578X231169366 . .

TY  - JOUR
AU  - Bajerska, Joanna
AU  - Skoczek-Rubińska, Aleksandra
AU  - Małczak, Lidia
AU  - Vučić, Vesna
AU  - Arsić, Aleksandra
AU  - Kojadinović, Milica
AU  - Ristić-Medić, Danijela
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1310
AB  - It is hypothesized that plasma proportion of selected fatty acids (FAs) and dietary habits are linked with the risk of cardiovascular disease (CVD) in postmenopausal women. Therefore, this study was designed to determine the association of plasma FA composition and markers of dietary habits with an atherogenic index of plasma (AIP), a predictor of CVD risk in postmenopausal women. In total, 87 postmenopausal women with an average age of 57 ± 7 years were recruited and their dietary intake, anthropometric and biochemical parameters, and FA status in total plasma lipid proportions were determined, showing that 65.5% of the participants had a high risk of CVD according to their AIP value. After adjusting for some confounders (age, body mass index, and physical activity level), the risk of CVD was only positively associated with the frequency of consumption of animal fat spreads (butter and lard) of terrestrial origin. Regarding the FA profile, CVD risk was positively associated with the percentages of vaccenic acid, dihomo-γ-linolenic acid, and monounsaturated fatty acids (MUFA; mainly n-7) in total FA, as well as the MUFA/SFA ratio in total plasma and stearoyl-CoA desaturase-16 activity (16:1/16:0 ratio). In contrast, the risk of CVD was negatively associated with percentages of α-linolenic acid, total polyunsaturated fatty acids (PUFA), and PUFA/MUFA ratio in total plasma lipid, and the estimated activity of Δ5-desaturase (20:4/20:3 n-6 ratio). These results support the current recommendations to decrease the frequency of animal fat spread intake because it is associated with a reduced CVD risk based on AIP in postmenopausal women. In accordance with these plasma percentages of ALA, vaccenic acid, dihomo-γ-linolenic acid, PUFA, PUFA/MUFA ratio, and 16:1/16:0 ratio may be important parameters in CVD risk assessment.
PB  - Elsevier
T2  - Nutrition Research
T2  - Nutrition ResearchNutrition Research
T1  - Plasma fatty acid composition and some markers of dietary habits are associated with cardiovascular disease risk determined by an atherogenic plasma index in postmenopausal women
EP  - 60
SP  - 47
VL  - 115
DO  - 10.1016/j.nutres.2023.05.008
ER  - 

@article{
author = "Bajerska, Joanna and Skoczek-Rubińska, Aleksandra and Małczak, Lidia and Vučić, Vesna and Arsić, Aleksandra and Kojadinović, Milica and Ristić-Medić, Danijela",
year = "2023",
abstract = "It is hypothesized that plasma proportion of selected fatty acids (FAs) and dietary habits are linked with the risk of cardiovascular disease (CVD) in postmenopausal women. Therefore, this study was designed to determine the association of plasma FA composition and markers of dietary habits with an atherogenic index of plasma (AIP), a predictor of CVD risk in postmenopausal women. In total, 87 postmenopausal women with an average age of 57 ± 7 years were recruited and their dietary intake, anthropometric and biochemical parameters, and FA status in total plasma lipid proportions were determined, showing that 65.5% of the participants had a high risk of CVD according to their AIP value. After adjusting for some confounders (age, body mass index, and physical activity level), the risk of CVD was only positively associated with the frequency of consumption of animal fat spreads (butter and lard) of terrestrial origin. Regarding the FA profile, CVD risk was positively associated with the percentages of vaccenic acid, dihomo-γ-linolenic acid, and monounsaturated fatty acids (MUFA; mainly n-7) in total FA, as well as the MUFA/SFA ratio in total plasma and stearoyl-CoA desaturase-16 activity (16:1/16:0 ratio). In contrast, the risk of CVD was negatively associated with percentages of α-linolenic acid, total polyunsaturated fatty acids (PUFA), and PUFA/MUFA ratio in total plasma lipid, and the estimated activity of Δ5-desaturase (20:4/20:3 n-6 ratio). These results support the current recommendations to decrease the frequency of animal fat spread intake because it is associated with a reduced CVD risk based on AIP in postmenopausal women. In accordance with these plasma percentages of ALA, vaccenic acid, dihomo-γ-linolenic acid, PUFA, PUFA/MUFA ratio, and 16:1/16:0 ratio may be important parameters in CVD risk assessment.",
publisher = "Elsevier",
journal = "Nutrition Research, Nutrition ResearchNutrition Research",
title = "Plasma fatty acid composition and some markers of dietary habits are associated with cardiovascular disease risk determined by an atherogenic plasma index in postmenopausal women",
pages = "60-47",
volume = "115",
doi = "10.1016/j.nutres.2023.05.008"
}

Bajerska, J., Skoczek-Rubińska, A., Małczak, L., Vučić, V., Arsić, A., Kojadinović, M.,& Ristić-Medić, D.. (2023). Plasma fatty acid composition and some markers of dietary habits are associated with cardiovascular disease risk determined by an atherogenic plasma index in postmenopausal women. in Nutrition Research
Elsevier., 115, 47-60.
https://doi.org/10.1016/j.nutres.2023.05.008

Bajerska J, Skoczek-Rubińska A, Małczak L, Vučić V, Arsić A, Kojadinović M, Ristić-Medić D. Plasma fatty acid composition and some markers of dietary habits are associated with cardiovascular disease risk determined by an atherogenic plasma index in postmenopausal women. in Nutrition Research. 2023;115:47-60.
doi:10.1016/j.nutres.2023.05.008 .

Bajerska, Joanna, Skoczek-Rubińska, Aleksandra, Małczak, Lidia, Vučić, Vesna, Arsić, Aleksandra, Kojadinović, Milica, Ristić-Medić, Danijela, "Plasma fatty acid composition and some markers of dietary habits are associated with cardiovascular disease risk determined by an atherogenic plasma index in postmenopausal women" in Nutrition Research, 115 (2023):47-60,
https://doi.org/10.1016/j.nutres.2023.05.008 . .

TY  - JOUR
AU  - Rajković, Katarina M.
AU  - Drobac, Milica
AU  - Milić, Petar
AU  - Vučić, Vesna
AU  - Arsić, Aleksandra
AU  - Perić, Mirijana
AU  - Radunović, Milena
AU  - Jeremić, Sanja
AU  - Arsenijević, Jelena
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1322
AB  - Juglans nigra (Black walnut) is a source of health-supporting biologically active compounds used in traditional medicine. The investigation of bioactive compounds in black walnut could lead to its broader application, as well as to the application of its by-products. Therefore, this study aimed to characterize J. nigra nut and green husk based on chemical analysis of their petroleum ether and ethanol extracts obtained by ultrasonic and reflux extraction methods, respectively. Different extract fractions were tested for their antimicrobial activities using Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa), Gram-positive bacteria (Enterococcus faecalis, Staphylococcus aureus) and yeast (reference strain and clinical isolates of Candida albicans). The ethanol extracts analysis, performed by high performance liquid chromatography, singled out the ellagic acid as the most dominant compound in nut ((55.0±1.3)×10-3 kg m-3) and green husk ((114.1±0.5)×10-3 kg m-3) extracts. Non-polar compounds were evaluated using gas chromatography analysis of petroleum ether extracts. Juglans nigra nut and green husk contained two saturated fatty acids, palmitic acid (C16:0) and stearic acid (C18:0), then, monounsaturated fatty acids, palmitoleic (C16:1n-7), oleic (C18:1n-9) and vaccenic acid (C18:1n-7), as well as polyunsaturated fatty acids, linoleic (C18:2n- -6), γ-linolenic (C18:3n-6) and α-linolenic (C18:3n-3) acids. Ethanol extracts of both J. nigra nut and green husk showed antimicrobial activity against C. albicans, which is the most common cause of yeast infections.
PB  - Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Chemical characterization and antimicrobial activity of Juglans nigra L. nut and green husk
EP  - 614
IS  - 6
SP  - 603
VL  - 88
DO  - 10.2298/JSC230210024R
ER  - 

@article{
author = "Rajković, Katarina M. and Drobac, Milica and Milić, Petar and Vučić, Vesna and Arsić, Aleksandra and Perić, Mirijana and Radunović, Milena and Jeremić, Sanja and Arsenijević, Jelena",
year = "2023",
abstract = "Juglans nigra (Black walnut) is a source of health-supporting biologically active compounds used in traditional medicine. The investigation of bioactive compounds in black walnut could lead to its broader application, as well as to the application of its by-products. Therefore, this study aimed to characterize J. nigra nut and green husk based on chemical analysis of their petroleum ether and ethanol extracts obtained by ultrasonic and reflux extraction methods, respectively. Different extract fractions were tested for their antimicrobial activities using Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa), Gram-positive bacteria (Enterococcus faecalis, Staphylococcus aureus) and yeast (reference strain and clinical isolates of Candida albicans). The ethanol extracts analysis, performed by high performance liquid chromatography, singled out the ellagic acid as the most dominant compound in nut ((55.0±1.3)×10-3 kg m-3) and green husk ((114.1±0.5)×10-3 kg m-3) extracts. Non-polar compounds were evaluated using gas chromatography analysis of petroleum ether extracts. Juglans nigra nut and green husk contained two saturated fatty acids, palmitic acid (C16:0) and stearic acid (C18:0), then, monounsaturated fatty acids, palmitoleic (C16:1n-7), oleic (C18:1n-9) and vaccenic acid (C18:1n-7), as well as polyunsaturated fatty acids, linoleic (C18:2n- -6), γ-linolenic (C18:3n-6) and α-linolenic (C18:3n-3) acids. Ethanol extracts of both J. nigra nut and green husk showed antimicrobial activity against C. albicans, which is the most common cause of yeast infections.",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society, Journal of the Serbian Chemical Society",
title = "Chemical characterization and antimicrobial activity of Juglans nigra L. nut and green husk",
pages = "614-603",
number = "6",
volume = "88",
doi = "10.2298/JSC230210024R"
}

Rajković, K. M., Drobac, M., Milić, P., Vučić, V., Arsić, A., Perić, M., Radunović, M., Jeremić, S.,& Arsenijević, J.. (2023). Chemical characterization and antimicrobial activity of Juglans nigra L. nut and green husk. in Journal of the Serbian Chemical Society
Serbian Chemical Society., 88(6), 603-614.
https://doi.org/10.2298/JSC230210024R

Rajković KM, Drobac M, Milić P, Vučić V, Arsić A, Perić M, Radunović M, Jeremić S, Arsenijević J. Chemical characterization and antimicrobial activity of Juglans nigra L. nut and green husk. in Journal of the Serbian Chemical Society. 2023;88(6):603-614.
doi:10.2298/JSC230210024R .

Rajković, Katarina M., Drobac, Milica, Milić, Petar, Vučić, Vesna, Arsić, Aleksandra, Perić, Mirijana, Radunović, Milena, Jeremić, Sanja, Arsenijević, Jelena, "Chemical characterization and antimicrobial activity of Juglans nigra L. nut and green husk" in Journal of the Serbian Chemical Society, 88, no. 6 (2023):603-614,
https://doi.org/10.2298/JSC230210024R . .

TY  - JOUR
AU  - Bokan, Goran
AU  - Glamočanin, Tanja
AU  - Mavija, Zoran
AU  - Vidović, Bojana
AU  - Stojanović, Ana
AU  - Björnsson, Einar S.
AU  - Vučić, Vesna
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1341
AB  - Herb-induced liver injury (HILI) caused by herbal supplements, natural products, and products used in traditional medicine are important for differential diagnoses in patients with acute liver injury without an obvious etiology. The root of Withania somnifera (L.) Dunal, commonly known as ashwagandha, has been used in Ayurvedic medicine for thousands of years to promote health and longevity. Due to various biological activities, ashwagandha and its extracts became widespread as herbal supplements on the global market. Although it is generally considered safe, there are several reported cases of ashwagandha-related liver injury, and one case ended with liver transplantation. In this paper, we review all reported cases so far. Additionally, we describe two new cases of ashwagandha hepatotoxicity. In the first case, a 36-year-old man used ashwagandha capsules (450 mg, three times daily) for 6 months before he developed nausea, pruritus, and dark-colored urine. In the second case, a 30-year-old woman developed pruritus after 45 days of using ashwagandha capsules (450 mg). In both cases, serum bilirubin and liver enzymes (aspartate transaminase (AST), alanine transaminase (ALT), and alkaline phosphatase (ALP) were increased. The liver injury pattern was hepatocellular (R-value 11.1) and mixed (R-value 2.6), respectively. The updated Roussel Uclaf Causality Assessment Method (RUCAM) (both cases with a score of seven) indicated a “probable” relationship with ashwagandha. Clinical and liver function improvements were observed after the discontinuation of ashwagandha supplement use. By increasing the data related to ashwagandha-induced liver injury, these reports support that consuming ashwagandha supplements is not without its safety concerns.
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Pharmaceuticals
T2  - Pharmaceuticals
T1  - Herb-Induced Liver Injury by Ayurvedic Ashwagandha as Assessed for Causality by the Updated RUCAM: An Emerging Cause
IS  - 8
VL  - 16
DO  - 10.3390/ph16081129
ER  - 

@article{
author = "Bokan, Goran and Glamočanin, Tanja and Mavija, Zoran and Vidović, Bojana and Stojanović, Ana and Björnsson, Einar S. and Vučić, Vesna",
year = "2023",
abstract = "Herb-induced liver injury (HILI) caused by herbal supplements, natural products, and products used in traditional medicine are important for differential diagnoses in patients with acute liver injury without an obvious etiology. The root of Withania somnifera (L.) Dunal, commonly known as ashwagandha, has been used in Ayurvedic medicine for thousands of years to promote health and longevity. Due to various biological activities, ashwagandha and its extracts became widespread as herbal supplements on the global market. Although it is generally considered safe, there are several reported cases of ashwagandha-related liver injury, and one case ended with liver transplantation. In this paper, we review all reported cases so far. Additionally, we describe two new cases of ashwagandha hepatotoxicity. In the first case, a 36-year-old man used ashwagandha capsules (450 mg, three times daily) for 6 months before he developed nausea, pruritus, and dark-colored urine. In the second case, a 30-year-old woman developed pruritus after 45 days of using ashwagandha capsules (450 mg). In both cases, serum bilirubin and liver enzymes (aspartate transaminase (AST), alanine transaminase (ALT), and alkaline phosphatase (ALP) were increased. The liver injury pattern was hepatocellular (R-value 11.1) and mixed (R-value 2.6), respectively. The updated Roussel Uclaf Causality Assessment Method (RUCAM) (both cases with a score of seven) indicated a “probable” relationship with ashwagandha. Clinical and liver function improvements were observed after the discontinuation of ashwagandha supplement use. By increasing the data related to ashwagandha-induced liver injury, these reports support that consuming ashwagandha supplements is not without its safety concerns.",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Pharmaceuticals, Pharmaceuticals",
title = "Herb-Induced Liver Injury by Ayurvedic Ashwagandha as Assessed for Causality by the Updated RUCAM: An Emerging Cause",
number = "8",
volume = "16",
doi = "10.3390/ph16081129"
}

Bokan, G., Glamočanin, T., Mavija, Z., Vidović, B., Stojanović, A., Björnsson, E. S.,& Vučić, V.. (2023). Herb-Induced Liver Injury by Ayurvedic Ashwagandha as Assessed for Causality by the Updated RUCAM: An Emerging Cause. in Pharmaceuticals
Multidisciplinary Digital Publishing Institute (MDPI)., 16(8).
https://doi.org/10.3390/ph16081129

Bokan G, Glamočanin T, Mavija Z, Vidović B, Stojanović A, Björnsson ES, Vučić V. Herb-Induced Liver Injury by Ayurvedic Ashwagandha as Assessed for Causality by the Updated RUCAM: An Emerging Cause. in Pharmaceuticals. 2023;16(8).
doi:10.3390/ph16081129 .

Bokan, Goran, Glamočanin, Tanja, Mavija, Zoran, Vidović, Bojana, Stojanović, Ana, Björnsson, Einar S., Vučić, Vesna, "Herb-Induced Liver Injury by Ayurvedic Ashwagandha as Assessed for Causality by the Updated RUCAM: An Emerging Cause" in Pharmaceuticals, 16, no. 8 (2023),
https://doi.org/10.3390/ph16081129 . .

TY  - JOUR
AU  - Ristić-Medić, Danijela
AU  - Petrović, Snježana
AU  - Polak, Tomaž
AU  - Bertoncelj, Jasna
AU  - Arsić, Aleksandra
AU  - Takić, Marija
AU  - Vučić, Vesna M.
AU  - Gurinović, Mirjana
AU  - Korošec, Mojca
PY  - 2022
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1232
AB  - Objectives: Industrially produced trans fatty acid (iTFA) have adverse health effects and thus their consumption should be limited. The aim of this study was to determine and compare the iTFA content in frequently consumed food products by young adults from the Serbian and Slovenian market with supposedly elevated iTFA content in 2015. At the time of this study, there was no recommended limit of iTFA in both countries, and reduction of iTFA in foods was on voluntary basis.Methods: We determined iTFA content in food products, 19 from the Serbian and 22 from the Slovenian market, blinded and analysed in the same analytical run. Contents of fatty acids (FA) methyl esters were analysed by capillary gas chromatography with a flame ionisation detector. Heptadecanoic acid was used as internal standard. Individual FA along with TFA were expressed as percentages of total measured FA. The amount of each FA in the sample was then calculated from the response factor and the transformation factor of the FA from the FA methyl ester content.Results: Elaidic acid (C18:1t) was found as the most abundant TFA in analysed products, ranging from 0.52 g/100 g of total FA in chocolate candy up to 60.4 g/100 g in a salami from Serbian market. In Slovenian products, the values for elaidic acid were lower, 0.04-3.95 g/100 g of total FA, except in one type of wafers (24.3 g/100 g).Conclusions: The majority of analysed products from the Serbian and three from Slovenian market exceeded the recommended WHO and EU limit of 2% iTFA of total fat in foods. Samples of frequently consumed salami, wafers, tea biscuits, and snacks were identified as products with potentially higher burden of iTFA in diets of young adults in Serbia.
T2  - Central European Journal of Public Health
T2  - Central European Journal of Public Health
T1  - Trans fatty acids in frequently consumed products from Serbian and Slovenian market
EP  - 57
IS  - 1
SP  - 51
VL  - 30
DO  - 10.21101/cejph.a5928
DO  - 10.21101/cejph.a5928
ER  - 

@article{
author = "Ristić-Medić, Danijela and Petrović, Snježana and Polak, Tomaž and Bertoncelj, Jasna and Arsić, Aleksandra and Takić, Marija and Vučić, Vesna M. and Gurinović, Mirjana and Korošec, Mojca",
year = "2022",
abstract = "Objectives: Industrially produced trans fatty acid (iTFA) have adverse health effects and thus their consumption should be limited. The aim of this study was to determine and compare the iTFA content in frequently consumed food products by young adults from the Serbian and Slovenian market with supposedly elevated iTFA content in 2015. At the time of this study, there was no recommended limit of iTFA in both countries, and reduction of iTFA in foods was on voluntary basis.Methods: We determined iTFA content in food products, 19 from the Serbian and 22 from the Slovenian market, blinded and analysed in the same analytical run. Contents of fatty acids (FA) methyl esters were analysed by capillary gas chromatography with a flame ionisation detector. Heptadecanoic acid was used as internal standard. Individual FA along with TFA were expressed as percentages of total measured FA. The amount of each FA in the sample was then calculated from the response factor and the transformation factor of the FA from the FA methyl ester content.Results: Elaidic acid (C18:1t) was found as the most abundant TFA in analysed products, ranging from 0.52 g/100 g of total FA in chocolate candy up to 60.4 g/100 g in a salami from Serbian market. In Slovenian products, the values for elaidic acid were lower, 0.04-3.95 g/100 g of total FA, except in one type of wafers (24.3 g/100 g).Conclusions: The majority of analysed products from the Serbian and three from Slovenian market exceeded the recommended WHO and EU limit of 2% iTFA of total fat in foods. Samples of frequently consumed salami, wafers, tea biscuits, and snacks were identified as products with potentially higher burden of iTFA in diets of young adults in Serbia.",
journal = "Central European Journal of Public Health, Central European Journal of Public Health",
title = "Trans fatty acids in frequently consumed products from Serbian and Slovenian market",
pages = "57-51",
number = "1",
volume = "30",
doi = "10.21101/cejph.a5928, 10.21101/cejph.a5928"
}

Ristić-Medić, D., Petrović, S., Polak, T., Bertoncelj, J., Arsić, A., Takić, M., Vučić, V. M., Gurinović, M.,& Korošec, M.. (2022). Trans fatty acids in frequently consumed products from Serbian and Slovenian market. in Central European Journal of Public Health, 30(1), 51-57.
https://doi.org/10.21101/cejph.a5928

Ristić-Medić D, Petrović S, Polak T, Bertoncelj J, Arsić A, Takić M, Vučić VM, Gurinović M, Korošec M. Trans fatty acids in frequently consumed products from Serbian and Slovenian market. in Central European Journal of Public Health. 2022;30(1):51-57.
doi:10.21101/cejph.a5928 .

Ristić-Medić, Danijela, Petrović, Snježana, Polak, Tomaž, Bertoncelj, Jasna, Arsić, Aleksandra, Takić, Marija, Vučić, Vesna M., Gurinović, Mirjana, Korošec, Mojca, "Trans fatty acids in frequently consumed products from Serbian and Slovenian market" in Central European Journal of Public Health, 30, no. 1 (2022):51-57,
https://doi.org/10.21101/cejph.a5928 . .

TY  - JOUR
AU  - Ristić-Medić, Danijela
AU  - Petrović, Snježana
AU  - Takić, Marija
AU  - Vučić, Vesna
AU  - Arsić, Aleksandra
AU  - Rađen, Slavica
AU  - Glibetić, Marija
PY  - 2022
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1338
AB  - Polyunsaturated fatty acid (PUFA) dietary intake, status and serum key fatty acid
(FA) ratios may aid in cardiovascular disease-related risk assessment. The aim of this study was to investigate
the effects of lipid-lowering diet on key FA ratios in serum phospholipids and omega-3 index in
erythrocyte phospholipids in moderately hyperlipidemic subjects. The study included 41 subjects, mean
age 56±6 years. Nutritional habits were evaluated by food frequency questionnaire. Participants followed
lipid lowering diet for 12 weeks. Energy intake of omega-6 and omega-3 FA was changed from 7.6%
and 0.6% to 5.7% and 1.2%, respectively. Marked decrease in four FA ratios in serum phospholipids,
i.e., omega-6/omega-3, arachidonic acid (AA)/eicosapentaenoic acid (EPA), AA/docosahexaenoic acid
(DHA), AA/(EPA+DHA) and omega-3 index (EPA+DHA) was found in study subjects after lipid-
lowering diet. Total cholesterol/high-density lipoprotein (HDL), low-density lipoprotein (LDL)/
HDL and triacylglycerol/HDL-cholesterol ratios positively correlated with all FA ratios, and negatively
correlated with total omega-3 levels in serum phospholipids and omega-3 index in erythrocytes. Total
serum omega-3 levels showed strongest association with lipoprotein ratios and positive correlation with
homeostatic model assessment (HOMA) index. In conclusion, lipid-lowering diet resulted in decreased
serum key FA ratios, increased omega-3 levels, and improved insulin sensitivity that may lead to a lower
risk of cardiovascular disease in subjects with moderate hyperlipidemia.
PB  - Klinicka bolnica Sestre Milosrdnice
T2  - Acta clinica Croatica
T1  - Efficacy of a Lipid-Lowering Diet on Key Fatty Acid Ratios and Omega-3 Index in Hyperlipidemic Subjects
EP  - 226
IS  - 2
SP  - 220
VL  - 61
DO  - 10.20471/acc.2022.61.02.08
ER  - 

@article{
author = "Ristić-Medić, Danijela and Petrović, Snježana and Takić, Marija and Vučić, Vesna and Arsić, Aleksandra and Rađen, Slavica and Glibetić, Marija",
year = "2022",
abstract = "Polyunsaturated fatty acid (PUFA) dietary intake, status and serum key fatty acid
(FA) ratios may aid in cardiovascular disease-related risk assessment. The aim of this study was to investigate
the effects of lipid-lowering diet on key FA ratios in serum phospholipids and omega-3 index in
erythrocyte phospholipids in moderately hyperlipidemic subjects. The study included 41 subjects, mean
age 56±6 years. Nutritional habits were evaluated by food frequency questionnaire. Participants followed
lipid lowering diet for 12 weeks. Energy intake of omega-6 and omega-3 FA was changed from 7.6%
and 0.6% to 5.7% and 1.2%, respectively. Marked decrease in four FA ratios in serum phospholipids,
i.e., omega-6/omega-3, arachidonic acid (AA)/eicosapentaenoic acid (EPA), AA/docosahexaenoic acid
(DHA), AA/(EPA+DHA) and omega-3 index (EPA+DHA) was found in study subjects after lipid-
lowering diet. Total cholesterol/high-density lipoprotein (HDL), low-density lipoprotein (LDL)/
HDL and triacylglycerol/HDL-cholesterol ratios positively correlated with all FA ratios, and negatively
correlated with total omega-3 levels in serum phospholipids and omega-3 index in erythrocytes. Total
serum omega-3 levels showed strongest association with lipoprotein ratios and positive correlation with
homeostatic model assessment (HOMA) index. In conclusion, lipid-lowering diet resulted in decreased
serum key FA ratios, increased omega-3 levels, and improved insulin sensitivity that may lead to a lower
risk of cardiovascular disease in subjects with moderate hyperlipidemia.",
publisher = "Klinicka bolnica Sestre Milosrdnice",
journal = "Acta clinica Croatica",
title = "Efficacy of a Lipid-Lowering Diet on Key Fatty Acid Ratios and Omega-3 Index in Hyperlipidemic Subjects",
pages = "226-220",
number = "2",
volume = "61",
doi = "10.20471/acc.2022.61.02.08"
}

Ristić-Medić, D., Petrović, S., Takić, M., Vučić, V., Arsić, A., Rađen, S.,& Glibetić, M.. (2022). Efficacy of a Lipid-Lowering Diet on Key Fatty Acid Ratios and Omega-3 Index in Hyperlipidemic Subjects. in Acta clinica Croatica
Klinicka bolnica Sestre Milosrdnice., 61(2), 220-226.
https://doi.org/10.20471/acc.2022.61.02.08

Ristić-Medić D, Petrović S, Takić M, Vučić V, Arsić A, Rađen S, Glibetić M. Efficacy of a Lipid-Lowering Diet on Key Fatty Acid Ratios and Omega-3 Index in Hyperlipidemic Subjects. in Acta clinica Croatica. 2022;61(2):220-226.
doi:10.20471/acc.2022.61.02.08 .

Ristić-Medić, Danijela, Petrović, Snježana, Takić, Marija, Vučić, Vesna, Arsić, Aleksandra, Rađen, Slavica, Glibetić, Marija, "Efficacy of a Lipid-Lowering Diet on Key Fatty Acid Ratios and Omega-3 Index in Hyperlipidemic Subjects" in Acta clinica Croatica, 61, no. 2 (2022):220-226,
https://doi.org/10.20471/acc.2022.61.02.08 . .

TY  - JOUR
AU  - Grabež, Milkica
AU  - Škrbić, Ranko
AU  - Stojiljković, Miloš P.
AU  - Vučić, Vesna M.
AU  - Grujić, Vesna Rudić
AU  - Jakovljević, Vladimir
AU  - Đurić, Dragan M.
AU  - Suručić, Relja
AU  - Šavikin, Katarina
AU  - Bigović, Dubravka
AU  - Vasiljević, Nađa
PY  - 2022
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1217
AB  - Type 2 diabetes mellitus (T2DM) is commonly associated with hyperglycemia, dyslipidemia, oxidative stress and inflammation which are well known cardiovascular risk factors. Pomegranate peel polyphenols have a proven hypolipemic, antioxidant and anti-inflammatory activity. However, there is a lack of clinical studies that would confirm its antioxidant and anti-inflammatory effects in diabetic patients. The potential of pomegranate peel extract (PoPEx) to counteract inflammation and oxidative stress in T2DM patients was investigated. For this purpose, a randomized, double-blind placebo-controlled study involving adult T2DM patients treated with PoPEx or placebo for eight-weeks was conducted. Methods: Patients were randomly divided into two groups: the first group (n = 30) received capsules containing PoPEx 250 mg twice daily, while the placebo group (n = 30) received placebo capsules twice daily. Plasma concentration of inflammatory factors (interleukin 6 (IL-6), tumor necrosis factor α (TNF-α) and high sensitivity C reactive protein (hsCRP)), oxidative stress biomarkers (thiobarbituric acid reactive substances (TBARS), nitrites (NO2−), superoxide anion radical (O2−), hydrogen peroxide (H2O2), total antioxidant capacity (TAC)), homocysteine and lipid profile were analyzed. Results: The PoPEx treatment showed a significant reduction of inflammatory factors (IL-6, TNF-α, hsCRP), oxidative stress biomarkers (TBARS, NO2−, O2−) and homocysteine, while the TAC was increased. Moreover, a significant improvement in lipid profile was observed in the PoPEx group. Additional analysis showed a significant inverse correlation between the decrements of all measured inflammatory markers and TAC in the PoPEx group. Conclusions: The study demonstrated that eight-week-long PoPEx administration had favorable effects on inflammatory status and oxidative stress biomarkers in diabetic patients.
T2  - Reviews in Cardiovascular Medicine
T2  - Reviews in Cardiovascular Medicine
T1  - A prospective, randomized, double-blind, placebo-controlled trial of polyphenols on the outcomes of inflammatory factors and oxidative stress in patients with type 2 diabetes mellitus
IS  - 2
SP  - 57
VL  - 23
DO  - 10.31083/j.rcm2302057
ER  - 

@article{
author = "Grabež, Milkica and Škrbić, Ranko and Stojiljković, Miloš P. and Vučić, Vesna M. and Grujić, Vesna Rudić and Jakovljević, Vladimir and Đurić, Dragan M. and Suručić, Relja and Šavikin, Katarina and Bigović, Dubravka and Vasiljević, Nađa",
year = "2022",
abstract = "Type 2 diabetes mellitus (T2DM) is commonly associated with hyperglycemia, dyslipidemia, oxidative stress and inflammation which are well known cardiovascular risk factors. Pomegranate peel polyphenols have a proven hypolipemic, antioxidant and anti-inflammatory activity. However, there is a lack of clinical studies that would confirm its antioxidant and anti-inflammatory effects in diabetic patients. The potential of pomegranate peel extract (PoPEx) to counteract inflammation and oxidative stress in T2DM patients was investigated. For this purpose, a randomized, double-blind placebo-controlled study involving adult T2DM patients treated with PoPEx or placebo for eight-weeks was conducted. Methods: Patients were randomly divided into two groups: the first group (n = 30) received capsules containing PoPEx 250 mg twice daily, while the placebo group (n = 30) received placebo capsules twice daily. Plasma concentration of inflammatory factors (interleukin 6 (IL-6), tumor necrosis factor α (TNF-α) and high sensitivity C reactive protein (hsCRP)), oxidative stress biomarkers (thiobarbituric acid reactive substances (TBARS), nitrites (NO2−), superoxide anion radical (O2−), hydrogen peroxide (H2O2), total antioxidant capacity (TAC)), homocysteine and lipid profile were analyzed. Results: The PoPEx treatment showed a significant reduction of inflammatory factors (IL-6, TNF-α, hsCRP), oxidative stress biomarkers (TBARS, NO2−, O2−) and homocysteine, while the TAC was increased. Moreover, a significant improvement in lipid profile was observed in the PoPEx group. Additional analysis showed a significant inverse correlation between the decrements of all measured inflammatory markers and TAC in the PoPEx group. Conclusions: The study demonstrated that eight-week-long PoPEx administration had favorable effects on inflammatory status and oxidative stress biomarkers in diabetic patients.",
journal = "Reviews in Cardiovascular Medicine, Reviews in Cardiovascular Medicine",
title = "A prospective, randomized, double-blind, placebo-controlled trial of polyphenols on the outcomes of inflammatory factors and oxidative stress in patients with type 2 diabetes mellitus",
number = "2",
pages = "57",
volume = "23",
doi = "10.31083/j.rcm2302057"
}

Grabež, M., Škrbić, R., Stojiljković, M. P., Vučić, V. M., Grujić, V. R., Jakovljević, V., Đurić, D. M., Suručić, R., Šavikin, K., Bigović, D.,& Vasiljević, N.. (2022). A prospective, randomized, double-blind, placebo-controlled trial of polyphenols on the outcomes of inflammatory factors and oxidative stress in patients with type 2 diabetes mellitus. in Reviews in Cardiovascular Medicine, 23(2), 57.
https://doi.org/10.31083/j.rcm2302057

Grabež M, Škrbić R, Stojiljković MP, Vučić VM, Grujić VR, Jakovljević V, Đurić DM, Suručić R, Šavikin K, Bigović D, Vasiljević N. A prospective, randomized, double-blind, placebo-controlled trial of polyphenols on the outcomes of inflammatory factors and oxidative stress in patients with type 2 diabetes mellitus. in Reviews in Cardiovascular Medicine. 2022;23(2):57.
doi:10.31083/j.rcm2302057 .

Grabež, Milkica, Škrbić, Ranko, Stojiljković, Miloš P., Vučić, Vesna M., Grujić, Vesna Rudić, Jakovljević, Vladimir, Đurić, Dragan M., Suručić, Relja, Šavikin, Katarina, Bigović, Dubravka, Vasiljević, Nađa, "A prospective, randomized, double-blind, placebo-controlled trial of polyphenols on the outcomes of inflammatory factors and oxidative stress in patients with type 2 diabetes mellitus" in Reviews in Cardiovascular Medicine, 23, no. 2 (2022):57,
https://doi.org/10.31083/j.rcm2302057 . .

TY  - JOUR
AU  - Ristić-Medić, Danijela
AU  - Bajerska, Joanna
AU  - Vučić, Vesna M.
PY  - 2022
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1247
AB  - The prevalence of nonalcoholic fatty liver disease (NAFLD) is rising worldwide, paralleling the epidemic of obesity. The liver is a key organ for the metabolism of proteins, fats and carbohydrates. Various types of fats and carbohydrates in isocaloric diets differently influence fat accumulation in the liver parenchyma. Therefore, nutrition can manage hepatic and cardiometabolic complications of NAFLD. Even moderately reduced caloric intake, which leads to a weight loss of 5%-10% of initial body weight, is effective in improving liver steatosis and surrogate markers of liver disease status. Among dietary patterns, the Mediterranean diet mostly prevents the onset of NAFLD. Furthermore, this diet is also the most recommended for the treatment of NAFLD patients. However, clinical trials based on the dietary interventions in NAFLD patients are sparse. Since there are only a few studies examining dietary interventions in clinically advanced stages of NAFLD, such as active and fibrotic steatohepatitis, the optimal diet for patients in these stages of the disease must still be determined. In this narrative review, we aimed to critically summarize the associations between different dietary patterns, obesity and prevention/risk for NAFLD, to describe specific dietary interventions’ impacts on liver steatosis in adults with NAFLD and to provide an updated overview of dietary recommendations that clinicians potentially need to apply in their daily practice.
T2  - World Journal of Gastroenterology
T1  - Crosstalk between dietary patterns, obesity and nonalcoholic fatty liver disease
EP  - 3333
IS  - 27
SP  - 3314
VL  - 28
DO  - 10.3748/wjg.v28.i27.3314
ER  - 

@article{
author = "Ristić-Medić, Danijela and Bajerska, Joanna and Vučić, Vesna M.",
year = "2022",
abstract = "The prevalence of nonalcoholic fatty liver disease (NAFLD) is rising worldwide, paralleling the epidemic of obesity. The liver is a key organ for the metabolism of proteins, fats and carbohydrates. Various types of fats and carbohydrates in isocaloric diets differently influence fat accumulation in the liver parenchyma. Therefore, nutrition can manage hepatic and cardiometabolic complications of NAFLD. Even moderately reduced caloric intake, which leads to a weight loss of 5%-10% of initial body weight, is effective in improving liver steatosis and surrogate markers of liver disease status. Among dietary patterns, the Mediterranean diet mostly prevents the onset of NAFLD. Furthermore, this diet is also the most recommended for the treatment of NAFLD patients. However, clinical trials based on the dietary interventions in NAFLD patients are sparse. Since there are only a few studies examining dietary interventions in clinically advanced stages of NAFLD, such as active and fibrotic steatohepatitis, the optimal diet for patients in these stages of the disease must still be determined. In this narrative review, we aimed to critically summarize the associations between different dietary patterns, obesity and prevention/risk for NAFLD, to describe specific dietary interventions’ impacts on liver steatosis in adults with NAFLD and to provide an updated overview of dietary recommendations that clinicians potentially need to apply in their daily practice.",
journal = "World Journal of Gastroenterology",
title = "Crosstalk between dietary patterns, obesity and nonalcoholic fatty liver disease",
pages = "3333-3314",
number = "27",
volume = "28",
doi = "10.3748/wjg.v28.i27.3314"
}

Ristić-Medić, D., Bajerska, J.,& Vučić, V. M.. (2022). Crosstalk between dietary patterns, obesity and nonalcoholic fatty liver disease. in World Journal of Gastroenterology, 28(27), 3314-3333.
https://doi.org/10.3748/wjg.v28.i27.3314

Ristić-Medić D, Bajerska J, Vučić VM. Crosstalk between dietary patterns, obesity and nonalcoholic fatty liver disease. in World Journal of Gastroenterology. 2022;28(27):3314-3333.
doi:10.3748/wjg.v28.i27.3314 .

Ristić-Medić, Danijela, Bajerska, Joanna, Vučić, Vesna M., "Crosstalk between dietary patterns, obesity and nonalcoholic fatty liver disease" in World Journal of Gastroenterology, 28, no. 27 (2022):3314-3333,
https://doi.org/10.3748/wjg.v28.i27.3314 . .

TY  - JOUR
AU  - Björnsson, Einar S.
AU  - Vučić, Vesna M.
AU  - Stirnimann, Guido
AU  - Robles-Díaz, Mercedes
PY  - 2022
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1216
AB  - Introduction: Apart from cessation of the implicated agent leading to drug-induced liver injury (DILI), there is no standard therapy for DILI. Corticosteroids have been used in DILI, although their efficacy is unclear. Published data showed either beneficial effects or no improvement associated with steroid therapy. The aim of the current study was to perform a systematic review of the role of corticosteroids in the treatment of DILI. Methods: A search was performed in PubMed, searching for the terms: “corticosteroids” and “drug-induced liver injury”. Observation studies were included, but case reports excluded. Results: A total of 24 papers were retrieved. Most of these were observational studies on the effects of corticosteroids in moderate/severe DILI (n = 8), reports on the corticosteroid treatment in patients with drug-induced autoimmune hepatitis (DI-AIH) (n = 5), and effects of corticosteroids in drug-induced fulminant acute liver failure (ALF, n = 2). Furthermore, treatment of corticosteroids in patients with liver injury due to check point inhibitors (CPIs) was addressed in nine studies. In moderate/severe DILI, six out of eight studies suggested steroid treatment to be beneficial, whereas two studies showed negative results. All five observational studies on the effects of corticosteroids in DI-AIH showed good therapeutic response with rapid and long lasting effects after discontinuation of corticosteroids and without evidence of relapse. Steroid therapy was not associated with improved overall survival in patients with drug-induced fulminant ALF. CPIs-induced liver injury was found to improve spontaneously in 33–50% without corticosteroids, and the rate of patients who were treated responded to steroids in 33–100% (mean 72%). Conclusions: The majority of studies analyzing the effects of corticosteroids in moderate/severe DILI have demonstrated beneficial effects. However, this was not the case in drug-induced fulminant ALF. Patients with DI-AIH had an excellent response to corticosteroids. The majority of those with CPIs-induced liver injury responded to corticosteroids; however, patients without treatment usually recovered spontaneously. The observational design and comparison with historical controls in these studies makes it very difficult to draw conclusions on the efficacy of corticosteroids in DILI. Therefore, there is a strong need for a randomized controlled trial to properly assess the role of corticosteroids in DILI.
PB  - Frontiers Media S.A.
T2  - Frontiers in Pharmacology
T1  - Role of Corticosteroids in Drug-Induced Liver Injury. A Systematic Review
SP  - 820724
VL  - 13
DO  - 10.3389/fphar.2022.820724
ER  - 

@article{
author = "Björnsson, Einar S. and Vučić, Vesna M. and Stirnimann, Guido and Robles-Díaz, Mercedes",
year = "2022",
abstract = "Introduction: Apart from cessation of the implicated agent leading to drug-induced liver injury (DILI), there is no standard therapy for DILI. Corticosteroids have been used in DILI, although their efficacy is unclear. Published data showed either beneficial effects or no improvement associated with steroid therapy. The aim of the current study was to perform a systematic review of the role of corticosteroids in the treatment of DILI. Methods: A search was performed in PubMed, searching for the terms: “corticosteroids” and “drug-induced liver injury”. Observation studies were included, but case reports excluded. Results: A total of 24 papers were retrieved. Most of these were observational studies on the effects of corticosteroids in moderate/severe DILI (n = 8), reports on the corticosteroid treatment in patients with drug-induced autoimmune hepatitis (DI-AIH) (n = 5), and effects of corticosteroids in drug-induced fulminant acute liver failure (ALF, n = 2). Furthermore, treatment of corticosteroids in patients with liver injury due to check point inhibitors (CPIs) was addressed in nine studies. In moderate/severe DILI, six out of eight studies suggested steroid treatment to be beneficial, whereas two studies showed negative results. All five observational studies on the effects of corticosteroids in DI-AIH showed good therapeutic response with rapid and long lasting effects after discontinuation of corticosteroids and without evidence of relapse. Steroid therapy was not associated with improved overall survival in patients with drug-induced fulminant ALF. CPIs-induced liver injury was found to improve spontaneously in 33–50% without corticosteroids, and the rate of patients who were treated responded to steroids in 33–100% (mean 72%). Conclusions: The majority of studies analyzing the effects of corticosteroids in moderate/severe DILI have demonstrated beneficial effects. However, this was not the case in drug-induced fulminant ALF. Patients with DI-AIH had an excellent response to corticosteroids. The majority of those with CPIs-induced liver injury responded to corticosteroids; however, patients without treatment usually recovered spontaneously. The observational design and comparison with historical controls in these studies makes it very difficult to draw conclusions on the efficacy of corticosteroids in DILI. Therefore, there is a strong need for a randomized controlled trial to properly assess the role of corticosteroids in DILI.",
publisher = "Frontiers Media S.A.",
journal = "Frontiers in Pharmacology",
title = "Role of Corticosteroids in Drug-Induced Liver Injury. A Systematic Review",
pages = "820724",
volume = "13",
doi = "10.3389/fphar.2022.820724"
}

Björnsson, E. S., Vučić, V. M., Stirnimann, G.,& Robles-Díaz, M.. (2022). Role of Corticosteroids in Drug-Induced Liver Injury. A Systematic Review. in Frontiers in Pharmacology
Frontiers Media S.A.., 13, 820724.
https://doi.org/10.3389/fphar.2022.820724

Björnsson ES, Vučić VM, Stirnimann G, Robles-Díaz M. Role of Corticosteroids in Drug-Induced Liver Injury. A Systematic Review. in Frontiers in Pharmacology. 2022;13:820724.
doi:10.3389/fphar.2022.820724 .

Björnsson, Einar S., Vučić, Vesna M., Stirnimann, Guido, Robles-Díaz, Mercedes, "Role of Corticosteroids in Drug-Induced Liver Injury. A Systematic Review" in Frontiers in Pharmacology, 13 (2022):820724,
https://doi.org/10.3389/fphar.2022.820724 . .

TY  - JOUR
AU  - Veselinović, Aleksandra
AU  - Petrović, Snježana
AU  - Žikić, Vladica
AU  - Subotić, Miško
AU  - Jakovljević, Vladimir
AU  - Jeremić, Nevena
AU  - Vučić, Vesna M.
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1161
AB  - Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder characterized by persistent deficits in social communication and social interaction across multiple contexts and restricted, repetitive patterns of behavior, interests and activities. The maternal status of polyunsaturated fatty acids (PUFA) regulates microglial activity and neuroinflammatory pathways during a child’s brain development. In children with ASD, the metabolism of PUFA is thought to be deficient or abnormal, leading to increased production of proinflammatory cytokines, increased oxidative stress and an imbalance in the formation and action of neurotransmitters. In addition, nutritional deficits in omega-3 PUFA may affect gut microbiota and contribute to ASD by the gut–brain axis. The aim of this study was to review the possible role of neuroinflammation in ASD development and the effect of omega-3 PUFA supplementation in children with ASD. Due to a wide heterogeneity across RCTs, no definitive conclusion about omega-3 PUFA effects in ASD can be drawn. Supplementation with PUFA could be considered as one of the aspects in regulating the biological status of the organism and could provide added value to standard medical and psychological interventions for reducing behavioral deficits.
PB  - MDPI
T2  - Medicina
T1  - Neuroinflammation in Autism and Supplementation Based on Omega-3 Polyunsaturated Fatty Acids: A Narrative Review
IS  - 9
SP  - 893
VL  - 57
DO  - 10.3390/medicina57090893
ER  - 

@article{
author = "Veselinović, Aleksandra and Petrović, Snježana and Žikić, Vladica and Subotić, Miško and Jakovljević, Vladimir and Jeremić, Nevena and Vučić, Vesna M.",
year = "2021",
abstract = "Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder characterized by persistent deficits in social communication and social interaction across multiple contexts and restricted, repetitive patterns of behavior, interests and activities. The maternal status of polyunsaturated fatty acids (PUFA) regulates microglial activity and neuroinflammatory pathways during a child’s brain development. In children with ASD, the metabolism of PUFA is thought to be deficient or abnormal, leading to increased production of proinflammatory cytokines, increased oxidative stress and an imbalance in the formation and action of neurotransmitters. In addition, nutritional deficits in omega-3 PUFA may affect gut microbiota and contribute to ASD by the gut–brain axis. The aim of this study was to review the possible role of neuroinflammation in ASD development and the effect of omega-3 PUFA supplementation in children with ASD. Due to a wide heterogeneity across RCTs, no definitive conclusion about omega-3 PUFA effects in ASD can be drawn. Supplementation with PUFA could be considered as one of the aspects in regulating the biological status of the organism and could provide added value to standard medical and psychological interventions for reducing behavioral deficits.",
publisher = "MDPI",
journal = "Medicina",
title = "Neuroinflammation in Autism and Supplementation Based on Omega-3 Polyunsaturated Fatty Acids: A Narrative Review",
number = "9",
pages = "893",
volume = "57",
doi = "10.3390/medicina57090893"
}

Veselinović, A., Petrović, S., Žikić, V., Subotić, M., Jakovljević, V., Jeremić, N.,& Vučić, V. M.. (2021). Neuroinflammation in Autism and Supplementation Based on Omega-3 Polyunsaturated Fatty Acids: A Narrative Review. in Medicina
MDPI., 57(9), 893.
https://doi.org/10.3390/medicina57090893

Veselinović A, Petrović S, Žikić V, Subotić M, Jakovljević V, Jeremić N, Vučić VM. Neuroinflammation in Autism and Supplementation Based on Omega-3 Polyunsaturated Fatty Acids: A Narrative Review. in Medicina. 2021;57(9):893.
doi:10.3390/medicina57090893 .

Veselinović, Aleksandra, Petrović, Snježana, Žikić, Vladica, Subotić, Miško, Jakovljević, Vladimir, Jeremić, Nevena, Vučić, Vesna M., "Neuroinflammation in Autism and Supplementation Based on Omega-3 Polyunsaturated Fatty Acids: A Narrative Review" in Medicina, 57, no. 9 (2021):893,
https://doi.org/10.3390/medicina57090893 . .

TY  - JOUR
AU  - Arsić, Aleksandra
AU  - Takić, Marija
AU  - Kojadinović, Milica
AU  - Petrović, Snježana
AU  - Paunović, Marija P.
AU  - Vučić, Vesna M.
AU  - Ristić-Medić, Danijela
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1070
AB  - The aim of this study was to compare dietary intake and status of polyunsaturated fatty acids (PUFA) in plasma and erythrocyte phospholipids metabolically healthy and unhealthy, and obese and nonobese persons. Metabolic health status in 171 participants was defined according to criteria for metabolic syndrome. Obese and nonobese metabolically unhealthy persons (MUHO and MUHNO) had higher energy intake of n-6 PUFA (7.82 +/- 1.03 and 7.49 +/- 0.86) and lower intake of n-3 PUFA (0.60 +/- 0.12 and 0.62 +/- 0.11) compared to obese and nonobese metabolically healthy persons (MHO and MHNO) (5.92 +/- 0.63 and 5.72 +/- 0.67; 1.20 +/- 0.07 and 1.22 +/- 0.09, respectively) and a higher n-6/n-3 PUFA ratio. The plasma level of n-6 PUFA was lower in the MUHO and MUHNO groups (38.49 +/- 3.71 and 38.53 +/- 2.19) compared to MHNO (40.90 +/- 2.43), while n-3 PUFA status was lower in obese than in nonobese persons (3.58 +/- 0.79 and 3.50 +/- 1.02 vs. 4.21 +/- 0.80 and 4.06 +/- 1.15). The MHO group had a higher eicosapentaenoic/arachidonic acid ratio and estimated desaturase (SCD16, D6D) and elongase activity in plasma phospholipids compared to MHNO. The low intake of n-3 PUFA is directly associated with metabolic risk factors. These results indicated that obesity is closely associated with low levels of n-3 PUFA in plasma phospholipids, suggesting that dietary modifications including n-3 PUFA supplementation appear to be suitable therapeutic strategy in obese persons.
PB  - Canadian Science Publishing, Ottawa
T2  - Canadian Journal of Physiology & Pharmacology
T1  - Metabolically healthy obesity: is there a link with polyunsaturated fatty acid intake and status?
EP  - 71
IS  - 1
SP  - 64
VL  - 99
DO  - 10.1139/cjpp-2020-0317
ER  - 

@article{
author = "Arsić, Aleksandra and Takić, Marija and Kojadinović, Milica and Petrović, Snježana and Paunović, Marija P. and Vučić, Vesna M. and Ristić-Medić, Danijela",
year = "2021",
abstract = "The aim of this study was to compare dietary intake and status of polyunsaturated fatty acids (PUFA) in plasma and erythrocyte phospholipids metabolically healthy and unhealthy, and obese and nonobese persons. Metabolic health status in 171 participants was defined according to criteria for metabolic syndrome. Obese and nonobese metabolically unhealthy persons (MUHO and MUHNO) had higher energy intake of n-6 PUFA (7.82 +/- 1.03 and 7.49 +/- 0.86) and lower intake of n-3 PUFA (0.60 +/- 0.12 and 0.62 +/- 0.11) compared to obese and nonobese metabolically healthy persons (MHO and MHNO) (5.92 +/- 0.63 and 5.72 +/- 0.67; 1.20 +/- 0.07 and 1.22 +/- 0.09, respectively) and a higher n-6/n-3 PUFA ratio. The plasma level of n-6 PUFA was lower in the MUHO and MUHNO groups (38.49 +/- 3.71 and 38.53 +/- 2.19) compared to MHNO (40.90 +/- 2.43), while n-3 PUFA status was lower in obese than in nonobese persons (3.58 +/- 0.79 and 3.50 +/- 1.02 vs. 4.21 +/- 0.80 and 4.06 +/- 1.15). The MHO group had a higher eicosapentaenoic/arachidonic acid ratio and estimated desaturase (SCD16, D6D) and elongase activity in plasma phospholipids compared to MHNO. The low intake of n-3 PUFA is directly associated with metabolic risk factors. These results indicated that obesity is closely associated with low levels of n-3 PUFA in plasma phospholipids, suggesting that dietary modifications including n-3 PUFA supplementation appear to be suitable therapeutic strategy in obese persons.",
publisher = "Canadian Science Publishing, Ottawa",
journal = "Canadian Journal of Physiology & Pharmacology",
title = "Metabolically healthy obesity: is there a link with polyunsaturated fatty acid intake and status?",
pages = "71-64",
number = "1",
volume = "99",
doi = "10.1139/cjpp-2020-0317"
}

Arsić, A., Takić, M., Kojadinović, M., Petrović, S., Paunović, M. P., Vučić, V. M.,& Ristić-Medić, D.. (2021). Metabolically healthy obesity: is there a link with polyunsaturated fatty acid intake and status?. in Canadian Journal of Physiology & Pharmacology
Canadian Science Publishing, Ottawa., 99(1), 64-71.
https://doi.org/10.1139/cjpp-2020-0317

Arsić A, Takić M, Kojadinović M, Petrović S, Paunović MP, Vučić VM, Ristić-Medić D. Metabolically healthy obesity: is there a link with polyunsaturated fatty acid intake and status?. in Canadian Journal of Physiology & Pharmacology. 2021;99(1):64-71.
doi:10.1139/cjpp-2020-0317 .

Arsić, Aleksandra, Takić, Marija, Kojadinović, Milica, Petrović, Snježana, Paunović, Marija P., Vučić, Vesna M., Ristić-Medić, Danijela, "Metabolically healthy obesity: is there a link with polyunsaturated fatty acid intake and status?" in Canadian Journal of Physiology & Pharmacology, 99, no. 1 (2021):64-71,
https://doi.org/10.1139/cjpp-2020-0317 . .

TY  - JOUR
AU  - Ristić-Medić, Danijela
AU  - Kovačić, Marijana
AU  - Takić, Marija
AU  - Arsić, Aleksandra
AU  - Petrović, Snježana
AU  - Paunović, Marija P.
AU  - Jovicić, Maja
AU  - Vučić, Vesna M.
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1071
AB  - Lifestyle modifications are the main support of nonalcoholic fatty liver disease (NAFLD) therapy. Weight loss is one of the primary goals in NAFLD, but the effects of different calorie-restricted diets remain unclear. Thus, we evaluated the effects of two calorie-restricted diets-the Mediterranean diet (Med diet) and low-fat diet-on liver status, cardiometabolic markers, and fatty acid profiles in patients with NAFLD. Twenty-four overweight/moderately obese men were randomly assigned to consume one of these diets. Lipid levels, glucose, insulin, liver enzymes, steatosis, and fatty acid profiles of serum and erythrocytes phospholipids were assessed. After 3 months, all participants had a significant weight loss ( gt 9%), with improvements in waist circumference, body fat %, index of visceral adiposity (VAI), lipid accumulation product, fatty liver (FLI), and hepatic steatosis (HSI) index (p  lt  0.001). Both diets significantly lowered triglycerides, total and LDL-cholesterol, liver enzymes, fasting glucose, insulin, and HOMA-IR index. Fatty acid profiles were enhanced after both diets, with a significantly decreased n-6/n-3 ratio. Participants on the Med diet had higher levels of HDL-cholesterol and monounsaturated and n-3 docosahexaenoic acids in serum phospholipids and lower levels of saturated fatty acids, triglycerides, TG/HDL ratio, and FLI when compared to participants on the low-fat diet. Our results indicate that dietary patterns and calorie restriction represent central therapeutic issues in the improvement of obesity-related cardiometabolic alterations that are involved in the mechanism of hepatic steatosis. The Med diet may contribute to disease treatment even more than the low-fat diet since it leads to decreased saturated and increased monounsaturated and n-3 polyunsaturated fatty acid status and improved FLI in NAFLD patients.
PB  - MDPI
T2  - Nutrients
T1  - Calorie-Restricted Mediterranean and Low-Fat Diets Affect Fatty Acid Status in Individuals with Nonalcoholic Fatty Liver Disease
IS  - 1
SP  - 15
VL  - 13
DO  - 10.3390/nu13010015
ER  - 

@article{
author = "Ristić-Medić, Danijela and Kovačić, Marijana and Takić, Marija and Arsić, Aleksandra and Petrović, Snježana and Paunović, Marija P. and Jovicić, Maja and Vučić, Vesna M.",
year = "2021",
abstract = "Lifestyle modifications are the main support of nonalcoholic fatty liver disease (NAFLD) therapy. Weight loss is one of the primary goals in NAFLD, but the effects of different calorie-restricted diets remain unclear. Thus, we evaluated the effects of two calorie-restricted diets-the Mediterranean diet (Med diet) and low-fat diet-on liver status, cardiometabolic markers, and fatty acid profiles in patients with NAFLD. Twenty-four overweight/moderately obese men were randomly assigned to consume one of these diets. Lipid levels, glucose, insulin, liver enzymes, steatosis, and fatty acid profiles of serum and erythrocytes phospholipids were assessed. After 3 months, all participants had a significant weight loss ( gt 9%), with improvements in waist circumference, body fat %, index of visceral adiposity (VAI), lipid accumulation product, fatty liver (FLI), and hepatic steatosis (HSI) index (p  lt  0.001). Both diets significantly lowered triglycerides, total and LDL-cholesterol, liver enzymes, fasting glucose, insulin, and HOMA-IR index. Fatty acid profiles were enhanced after both diets, with a significantly decreased n-6/n-3 ratio. Participants on the Med diet had higher levels of HDL-cholesterol and monounsaturated and n-3 docosahexaenoic acids in serum phospholipids and lower levels of saturated fatty acids, triglycerides, TG/HDL ratio, and FLI when compared to participants on the low-fat diet. Our results indicate that dietary patterns and calorie restriction represent central therapeutic issues in the improvement of obesity-related cardiometabolic alterations that are involved in the mechanism of hepatic steatosis. The Med diet may contribute to disease treatment even more than the low-fat diet since it leads to decreased saturated and increased monounsaturated and n-3 polyunsaturated fatty acid status and improved FLI in NAFLD patients.",
publisher = "MDPI",
journal = "Nutrients",
title = "Calorie-Restricted Mediterranean and Low-Fat Diets Affect Fatty Acid Status in Individuals with Nonalcoholic Fatty Liver Disease",
number = "1",
pages = "15",
volume = "13",
doi = "10.3390/nu13010015"
}

Ristić-Medić, D., Kovačić, M., Takić, M., Arsić, A., Petrović, S., Paunović, M. P., Jovicić, M.,& Vučić, V. M.. (2021). Calorie-Restricted Mediterranean and Low-Fat Diets Affect Fatty Acid Status in Individuals with Nonalcoholic Fatty Liver Disease. in Nutrients
MDPI., 13(1), 15.
https://doi.org/10.3390/nu13010015

Ristić-Medić D, Kovačić M, Takić M, Arsić A, Petrović S, Paunović MP, Jovicić M, Vučić VM. Calorie-Restricted Mediterranean and Low-Fat Diets Affect Fatty Acid Status in Individuals with Nonalcoholic Fatty Liver Disease. in Nutrients. 2021;13(1):15.
doi:10.3390/nu13010015 .

Ristić-Medić, Danijela, Kovačić, Marijana, Takić, Marija, Arsić, Aleksandra, Petrović, Snježana, Paunović, Marija P., Jovicić, Maja, Vučić, Vesna M., "Calorie-Restricted Mediterranean and Low-Fat Diets Affect Fatty Acid Status in Individuals with Nonalcoholic Fatty Liver Disease" in Nutrients, 13, no. 1 (2021):15,
https://doi.org/10.3390/nu13010015 . .

TY  - JOUR
AU  - Ristić-Medić, Danijela
AU  - Petrović, Snježana
AU  - Arsić, Aleksandra
AU  - Vučić, Vesna M.
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1166
AB  - Varying degrees of liver injuries have been reported in patients infected with the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). In general, oxidative stress is actively involved in initiation and progression of liver damage. The liver metabolizes various compounds that produce free radicals. Maintaining the oxidative/antioxidative balance is important in coronavirus disease 2019 (COVID-19) patients. Antioxidant vitamins, essential trace elements and food compounds, such as polyphenols, appear to be promising agents, with effects in oxidative burst. Deficiency of these nutrients suppresses immune function and increases susceptibility to COVID-19. Daily micronutrient intake is necessary to support anti-inflammatory and antioxidative effects but for immune function may be higher than current recommended dietary intake. Antioxidant supplements (βcarotene, vitamin A, vitamin C, vitamin E, and selenium) could have a potential role in patients with liver damage. Available evidence suggests that supplementing the diet with a combination of micronutrients may help to optimize immune function and reduce the risk of infection. Clinical trials based on the associations of diet and SARS-CoV-2 infection are lacking. Unfortunately, it is not possible to definitively determine the dose, route of administration and best timing to intervene with antioxidants in COVID-19 patients because clinical trials are still ongoing. Until then, hopefully, this review will enable clinicians to understand the impact of micronutrient dietary intake and liver status assessment in COVID-19 patients.
PB  - Baishideng Publishing Group
T2  - World Journal of Gastroenterology
T1  - Liver disease and COVID-19: The link with oxidative stress, antioxidants and nutrition
EP  - 5699
IS  - 34
SP  - 5682
VL  - 27
DO  - 10.3748/wjg.v27.i34.5682
ER  - 

@article{
author = "Ristić-Medić, Danijela and Petrović, Snježana and Arsić, Aleksandra and Vučić, Vesna M.",
year = "2021",
abstract = "Varying degrees of liver injuries have been reported in patients infected with the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). In general, oxidative stress is actively involved in initiation and progression of liver damage. The liver metabolizes various compounds that produce free radicals. Maintaining the oxidative/antioxidative balance is important in coronavirus disease 2019 (COVID-19) patients. Antioxidant vitamins, essential trace elements and food compounds, such as polyphenols, appear to be promising agents, with effects in oxidative burst. Deficiency of these nutrients suppresses immune function and increases susceptibility to COVID-19. Daily micronutrient intake is necessary to support anti-inflammatory and antioxidative effects but for immune function may be higher than current recommended dietary intake. Antioxidant supplements (βcarotene, vitamin A, vitamin C, vitamin E, and selenium) could have a potential role in patients with liver damage. Available evidence suggests that supplementing the diet with a combination of micronutrients may help to optimize immune function and reduce the risk of infection. Clinical trials based on the associations of diet and SARS-CoV-2 infection are lacking. Unfortunately, it is not possible to definitively determine the dose, route of administration and best timing to intervene with antioxidants in COVID-19 patients because clinical trials are still ongoing. Until then, hopefully, this review will enable clinicians to understand the impact of micronutrient dietary intake and liver status assessment in COVID-19 patients.",
publisher = "Baishideng Publishing Group",
journal = "World Journal of Gastroenterology",
title = "Liver disease and COVID-19: The link with oxidative stress, antioxidants and nutrition",
pages = "5699-5682",
number = "34",
volume = "27",
doi = "10.3748/wjg.v27.i34.5682"
}

Ristić-Medić, D., Petrović, S., Arsić, A.,& Vučić, V. M.. (2021). Liver disease and COVID-19: The link with oxidative stress, antioxidants and nutrition. in World Journal of Gastroenterology
Baishideng Publishing Group., 27(34), 5682-5699.
https://doi.org/10.3748/wjg.v27.i34.5682

Ristić-Medić D, Petrović S, Arsić A, Vučić VM. Liver disease and COVID-19: The link with oxidative stress, antioxidants and nutrition. in World Journal of Gastroenterology. 2021;27(34):5682-5699.
doi:10.3748/wjg.v27.i34.5682 .

Ristić-Medić, Danijela, Petrović, Snježana, Arsić, Aleksandra, Vučić, Vesna M., "Liver disease and COVID-19: The link with oxidative stress, antioxidants and nutrition" in World Journal of Gastroenterology, 27, no. 34 (2021):5682-5699,
https://doi.org/10.3748/wjg.v27.i34.5682 . .

TY  - JOUR
AU  - Milošević, Maja
AU  - Arsić, Aleksandra
AU  - Cvetković, Zorica
AU  - Vučić, Vesna M.
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1153
AB  - Healthcare systems worldwide are seriously challenged by a rising prevalence of neurodegenerative diseases (NDDs), which mostly, but not exclusively, affect the ever-growing population of the elderly. The most known neurodegenerative diseases are Alzheimer's (AD) and Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis, but some viral infections of the brain and traumatic brain injury may also cause NDD. Typical for NDD are the malfunctioning of neurons and their irreversible loss, which often progress irreversibly to dementia and ultimately to death. Numerous factors are involved in the pathogenesis of NDD: genetic variability, epigenetic changes, extent of oxidative/nitrosative stress, mitochondrial dysfunction, and DNA damage. The complex interplay of all the above-mentioned factors may be a fingerprint of neurodegeneration, with different diseases being affected to different extents by particular factors. There is a voluminous body of evidence showing the benefits of regular exercise to brain health and cognitive functions. Moreover, the importance of a healthy diet, balanced in macro- and micro-nutrients, in preventing neurodegeneration and slowing down a progression to full-blown disease is evident. Individuals affected by NDD almost inevitably have low-grade inflammation and anomalies in lipid metabolism. Metabolic and lipid profiles in NDD can be improved by the Mediterranean diet. Many studies have associated the Mediterranean diet with a decreased risk of dementia and AD, but a cause-and-effect relationship has not been deduced. Studies with caloric restriction showed neuroprotective effects in animal models, but the results in humans are inconsistent. The pathologies of NDD are complex and there is a great inter-individual (epi)genetic variance within any population. Furthermore, the gut microbiome, being deeply involved in nutrient uptake and lipid metabolism, also represents a pillar of the gut microbiome–brain axis and is linked with the pathogenesis of NDD. Numerous studies on the role of different micronutrients (omega-3 fatty acids, bioactive polyphenols from fruit and medicinal plants) in the prevention, prediction, and treatment of NDD have been conducted, but we are still far away from a personalized diet plan for individual NDD patients. For this to be realized, large-scale cohorts that would include the precise monitoring of food intake, mapping of genetic variants, epigenetic data, microbiome studies, and metabolome, lipidome, and transcriptome data are needed.
PB  - Frontiers Media S.A.
T2  - Frontiers in Nutrition
T1  - Memorable Food: Fighting Age-Related Neurodegeneration by Precision Nutrition
SP  - 688086
VL  - 8
DO  - 10.3389/fnut.2021.688086
ER  - 

@article{
author = "Milošević, Maja and Arsić, Aleksandra and Cvetković, Zorica and Vučić, Vesna M.",
year = "2021",
abstract = "Healthcare systems worldwide are seriously challenged by a rising prevalence of neurodegenerative diseases (NDDs), which mostly, but not exclusively, affect the ever-growing population of the elderly. The most known neurodegenerative diseases are Alzheimer's (AD) and Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis, but some viral infections of the brain and traumatic brain injury may also cause NDD. Typical for NDD are the malfunctioning of neurons and their irreversible loss, which often progress irreversibly to dementia and ultimately to death. Numerous factors are involved in the pathogenesis of NDD: genetic variability, epigenetic changes, extent of oxidative/nitrosative stress, mitochondrial dysfunction, and DNA damage. The complex interplay of all the above-mentioned factors may be a fingerprint of neurodegeneration, with different diseases being affected to different extents by particular factors. There is a voluminous body of evidence showing the benefits of regular exercise to brain health and cognitive functions. Moreover, the importance of a healthy diet, balanced in macro- and micro-nutrients, in preventing neurodegeneration and slowing down a progression to full-blown disease is evident. Individuals affected by NDD almost inevitably have low-grade inflammation and anomalies in lipid metabolism. Metabolic and lipid profiles in NDD can be improved by the Mediterranean diet. Many studies have associated the Mediterranean diet with a decreased risk of dementia and AD, but a cause-and-effect relationship has not been deduced. Studies with caloric restriction showed neuroprotective effects in animal models, but the results in humans are inconsistent. The pathologies of NDD are complex and there is a great inter-individual (epi)genetic variance within any population. Furthermore, the gut microbiome, being deeply involved in nutrient uptake and lipid metabolism, also represents a pillar of the gut microbiome–brain axis and is linked with the pathogenesis of NDD. Numerous studies on the role of different micronutrients (omega-3 fatty acids, bioactive polyphenols from fruit and medicinal plants) in the prevention, prediction, and treatment of NDD have been conducted, but we are still far away from a personalized diet plan for individual NDD patients. For this to be realized, large-scale cohorts that would include the precise monitoring of food intake, mapping of genetic variants, epigenetic data, microbiome studies, and metabolome, lipidome, and transcriptome data are needed.",
publisher = "Frontiers Media S.A.",
journal = "Frontiers in Nutrition",
title = "Memorable Food: Fighting Age-Related Neurodegeneration by Precision Nutrition",
pages = "688086",
volume = "8",
doi = "10.3389/fnut.2021.688086"
}

Milošević, M., Arsić, A., Cvetković, Z.,& Vučić, V. M.. (2021). Memorable Food: Fighting Age-Related Neurodegeneration by Precision Nutrition. in Frontiers in Nutrition
Frontiers Media S.A.., 8, 688086.
https://doi.org/10.3389/fnut.2021.688086

Milošević M, Arsić A, Cvetković Z, Vučić VM. Memorable Food: Fighting Age-Related Neurodegeneration by Precision Nutrition. in Frontiers in Nutrition. 2021;8:688086.
doi:10.3389/fnut.2021.688086 .

Milošević, Maja, Arsić, Aleksandra, Cvetković, Zorica, Vučić, Vesna M., "Memorable Food: Fighting Age-Related Neurodegeneration by Precision Nutrition" in Frontiers in Nutrition, 8 (2021):688086,
https://doi.org/10.3389/fnut.2021.688086 . .