Efficacy of a Lipid-Lowering Diet on Key Fatty Acid Ratios and Omega-3 Index in Hyperlipidemic Subjects
Аутори
Ristić-Medić, DanijelaPetrović, Snježana
Takić, Marija
Vučić, Vesna
Arsić, Aleksandra
Rađen, Slavica
Glibetić, Marija
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Polyunsaturated fatty acid (PUFA) dietary intake, status and serum key fatty acid
(FA) ratios may aid in cardiovascular disease-related risk assessment. The aim of this study was to investigate
the effects of lipid-lowering diet on key FA ratios in serum phospholipids and omega-3 index in
erythrocyte phospholipids in moderately hyperlipidemic subjects. The study included 41 subjects, mean
age 56±6 years. Nutritional habits were evaluated by food frequency questionnaire. Participants followed
lipid lowering diet for 12 weeks. Energy intake of omega-6 and omega-3 FA was changed from 7.6%
and 0.6% to 5.7% and 1.2%, respectively. Marked decrease in four FA ratios in serum phospholipids,
i.e., omega-6/omega-3, arachidonic acid (AA)/eicosapentaenoic acid (EPA), AA/docosahexaenoic acid
(DHA), AA/(EPA+DHA) and omega-3 index (EPA+DHA) was found in study subjects after lipid-
lowering diet. Total cholesterol/high-density lipoprotein (HDL), low-density lipoprotein (LDL)/
HDL and triacyl...glycerol/HDL-cholesterol ratios positively correlated with all FA ratios, and negatively
correlated with total omega-3 levels in serum phospholipids and omega-3 index in erythrocytes. Total
serum omega-3 levels showed strongest association with lipoprotein ratios and positive correlation with
homeostatic model assessment (HOMA) index. In conclusion, lipid-lowering diet resulted in decreased
serum key FA ratios, increased omega-3 levels, and improved insulin sensitivity that may lead to a lower
risk of cardiovascular disease in subjects with moderate hyperlipidemia.
Кључне речи:
Fatty acid ratio / Hyperlipidemia / Lipid-lowering diet / Omega 3-index / TG/HDLИзвор:
Acta clinica Croatica, 2022, 61, 2, 220-226Издавач:
- Klinicka bolnica Sestre Milosrdnice
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200015 (Универзитет у Београду, Институт за медицинска истраживања) (RS-MESTD-inst-2020-200015)
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Ristić-Medić, Danijela AU - Petrović, Snježana AU - Takić, Marija AU - Vučić, Vesna AU - Arsić, Aleksandra AU - Rađen, Slavica AU - Glibetić, Marija PY - 2022 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1338 AB - Polyunsaturated fatty acid (PUFA) dietary intake, status and serum key fatty acid (FA) ratios may aid in cardiovascular disease-related risk assessment. The aim of this study was to investigate the effects of lipid-lowering diet on key FA ratios in serum phospholipids and omega-3 index in erythrocyte phospholipids in moderately hyperlipidemic subjects. The study included 41 subjects, mean age 56±6 years. Nutritional habits were evaluated by food frequency questionnaire. Participants followed lipid lowering diet for 12 weeks. Energy intake of omega-6 and omega-3 FA was changed from 7.6% and 0.6% to 5.7% and 1.2%, respectively. Marked decrease in four FA ratios in serum phospholipids, i.e., omega-6/omega-3, arachidonic acid (AA)/eicosapentaenoic acid (EPA), AA/docosahexaenoic acid (DHA), AA/(EPA+DHA) and omega-3 index (EPA+DHA) was found in study subjects after lipid- lowering diet. Total cholesterol/high-density lipoprotein (HDL), low-density lipoprotein (LDL)/ HDL and triacylglycerol/HDL-cholesterol ratios positively correlated with all FA ratios, and negatively correlated with total omega-3 levels in serum phospholipids and omega-3 index in erythrocytes. Total serum omega-3 levels showed strongest association with lipoprotein ratios and positive correlation with homeostatic model assessment (HOMA) index. In conclusion, lipid-lowering diet resulted in decreased serum key FA ratios, increased omega-3 levels, and improved insulin sensitivity that may lead to a lower risk of cardiovascular disease in subjects with moderate hyperlipidemia. PB - Klinicka bolnica Sestre Milosrdnice T2 - Acta clinica Croatica T1 - Efficacy of a Lipid-Lowering Diet on Key Fatty Acid Ratios and Omega-3 Index in Hyperlipidemic Subjects EP - 226 IS - 2 SP - 220 VL - 61 DO - 10.20471/acc.2022.61.02.08 ER -
@article{ author = "Ristić-Medić, Danijela and Petrović, Snježana and Takić, Marija and Vučić, Vesna and Arsić, Aleksandra and Rađen, Slavica and Glibetić, Marija", year = "2022", abstract = "Polyunsaturated fatty acid (PUFA) dietary intake, status and serum key fatty acid (FA) ratios may aid in cardiovascular disease-related risk assessment. The aim of this study was to investigate the effects of lipid-lowering diet on key FA ratios in serum phospholipids and omega-3 index in erythrocyte phospholipids in moderately hyperlipidemic subjects. The study included 41 subjects, mean age 56±6 years. Nutritional habits were evaluated by food frequency questionnaire. Participants followed lipid lowering diet for 12 weeks. Energy intake of omega-6 and omega-3 FA was changed from 7.6% and 0.6% to 5.7% and 1.2%, respectively. Marked decrease in four FA ratios in serum phospholipids, i.e., omega-6/omega-3, arachidonic acid (AA)/eicosapentaenoic acid (EPA), AA/docosahexaenoic acid (DHA), AA/(EPA+DHA) and omega-3 index (EPA+DHA) was found in study subjects after lipid- lowering diet. Total cholesterol/high-density lipoprotein (HDL), low-density lipoprotein (LDL)/ HDL and triacylglycerol/HDL-cholesterol ratios positively correlated with all FA ratios, and negatively correlated with total omega-3 levels in serum phospholipids and omega-3 index in erythrocytes. Total serum omega-3 levels showed strongest association with lipoprotein ratios and positive correlation with homeostatic model assessment (HOMA) index. In conclusion, lipid-lowering diet resulted in decreased serum key FA ratios, increased omega-3 levels, and improved insulin sensitivity that may lead to a lower risk of cardiovascular disease in subjects with moderate hyperlipidemia.", publisher = "Klinicka bolnica Sestre Milosrdnice", journal = "Acta clinica Croatica", title = "Efficacy of a Lipid-Lowering Diet on Key Fatty Acid Ratios and Omega-3 Index in Hyperlipidemic Subjects", pages = "226-220", number = "2", volume = "61", doi = "10.20471/acc.2022.61.02.08" }
Ristić-Medić, D., Petrović, S., Takić, M., Vučić, V., Arsić, A., Rađen, S.,& Glibetić, M.. (2022). Efficacy of a Lipid-Lowering Diet on Key Fatty Acid Ratios and Omega-3 Index in Hyperlipidemic Subjects. in Acta clinica Croatica Klinicka bolnica Sestre Milosrdnice., 61(2), 220-226. https://doi.org/10.20471/acc.2022.61.02.08
Ristić-Medić D, Petrović S, Takić M, Vučić V, Arsić A, Rađen S, Glibetić M. Efficacy of a Lipid-Lowering Diet on Key Fatty Acid Ratios and Omega-3 Index in Hyperlipidemic Subjects. in Acta clinica Croatica. 2022;61(2):220-226. doi:10.20471/acc.2022.61.02.08 .
Ristić-Medić, Danijela, Petrović, Snježana, Takić, Marija, Vučić, Vesna, Arsić, Aleksandra, Rađen, Slavica, Glibetić, Marija, "Efficacy of a Lipid-Lowering Diet on Key Fatty Acid Ratios and Omega-3 Index in Hyperlipidemic Subjects" in Acta clinica Croatica, 61, no. 2 (2022):220-226, https://doi.org/10.20471/acc.2022.61.02.08 . .