TY  - JOUR
AU  - Ivanov, Milan
AU  - Brkić, Predrag
AU  - Vajić, Una Jovana
AU  - Mihailović-Stanojević, Nevena
AU  - Milačić, Davorka
AU  - Jovović, Đurđica
AU  - Karanović, Danijela
AU  - Đelić, Marina
AU  - Jeremić, Rada
AU  - Miloradović, Zoran
PY  - 2020
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1063
AB  - Background: Acute kidney injury (AKI) as a consequence of ischemia is a common clinical event that can lead to unacceptably high morbidity and mortality. Hyperbaric oxygen (HBO2) preconditioning has been shown to prevent ischemia-reperfusion injury (IRI) in different tissues. Objectives: The aim of our study was to compare the effects of HBO2 preconditioning on renal hemodynamics, kidney function and oxidative stress in normotensive and spontaneously hypertensive rats that suffered kidney IRI. Methods: An experiment was performed on Wistar (normotensive) and spontaneously hypertensive rats (SHR). The animals were divided into the following experimental groups: sham-operated rats and rats with or without HBO2 preconditioning 24 hours before post-ischemic AKI induction. Treated rats were placed into experimental HBO2 chambers and exposed to pure oxygen twice a day for two consecutive days (2.026 bar of oxygen) for 60 minutes. AKI was performed the next morning. The right kidney was removed and the renal ischemia was performed by clamping the left renal artery for 45 minutes. Results: In this study, HBO2 preconditioning significantly improved disturbed renal hemodynamics, major markers of kidney function in plasma (creatinine, urea and phosphate) as well as antioxidant enzymes (superoxide dismutase and catalase) activities in erythrocytes after AKI induction. Also, HBO2 preconditioning decreased lipid peroxidation in plasma after ischemic AKI. Positive effects were observed in both strains of rats. Conclusions: Our results suggest that HBO2 treatment improves renal hemodynamic and kidney function and decreases oxidative stress of Wistar and SHR rats with an AKI episode. Furthermore, it also implies that pre-existing hypertension does not affect the beneficial effects of HBO2 preconditioning.
PB  - Undersea & Hyperbaric Medical Soc Inc, Durham
T2  - Undersea & hyperbaric medicine : journal of the Undersea & Hyperbaric Medical Society, Inc
T1  - Hyperbaric oxygenation protects the kidney against ischemia-reperfusion injury
EP  - 30
IS  - 1
SP  - 21
VL  - 47
UR  - https://hdl.handle.net/21.15107/rcub_rimi_1063
ER  - 

@article{
author = "Ivanov, Milan and Brkić, Predrag and Vajić, Una Jovana and Mihailović-Stanojević, Nevena and Milačić, Davorka and Jovović, Đurđica and Karanović, Danijela and Đelić, Marina and Jeremić, Rada and Miloradović, Zoran",
year = "2020",
abstract = "Background: Acute kidney injury (AKI) as a consequence of ischemia is a common clinical event that can lead to unacceptably high morbidity and mortality. Hyperbaric oxygen (HBO2) preconditioning has been shown to prevent ischemia-reperfusion injury (IRI) in different tissues. Objectives: The aim of our study was to compare the effects of HBO2 preconditioning on renal hemodynamics, kidney function and oxidative stress in normotensive and spontaneously hypertensive rats that suffered kidney IRI. Methods: An experiment was performed on Wistar (normotensive) and spontaneously hypertensive rats (SHR). The animals were divided into the following experimental groups: sham-operated rats and rats with or without HBO2 preconditioning 24 hours before post-ischemic AKI induction. Treated rats were placed into experimental HBO2 chambers and exposed to pure oxygen twice a day for two consecutive days (2.026 bar of oxygen) for 60 minutes. AKI was performed the next morning. The right kidney was removed and the renal ischemia was performed by clamping the left renal artery for 45 minutes. Results: In this study, HBO2 preconditioning significantly improved disturbed renal hemodynamics, major markers of kidney function in plasma (creatinine, urea and phosphate) as well as antioxidant enzymes (superoxide dismutase and catalase) activities in erythrocytes after AKI induction. Also, HBO2 preconditioning decreased lipid peroxidation in plasma after ischemic AKI. Positive effects were observed in both strains of rats. Conclusions: Our results suggest that HBO2 treatment improves renal hemodynamic and kidney function and decreases oxidative stress of Wistar and SHR rats with an AKI episode. Furthermore, it also implies that pre-existing hypertension does not affect the beneficial effects of HBO2 preconditioning.",
publisher = "Undersea & Hyperbaric Medical Soc Inc, Durham",
journal = "Undersea & hyperbaric medicine : journal of the Undersea & Hyperbaric Medical Society, Inc",
title = "Hyperbaric oxygenation protects the kidney against ischemia-reperfusion injury",
pages = "30-21",
number = "1",
volume = "47",
url = "https://hdl.handle.net/21.15107/rcub_rimi_1063"
}

Ivanov, M., Brkić, P., Vajić, U. J., Mihailović-Stanojević, N., Milačić, D., Jovović, Đ., Karanović, D., Đelić, M., Jeremić, R.,& Miloradović, Z.. (2020). Hyperbaric oxygenation protects the kidney against ischemia-reperfusion injury. in Undersea & hyperbaric medicine : journal of the Undersea & Hyperbaric Medical Society, Inc
Undersea & Hyperbaric Medical Soc Inc, Durham., 47(1), 21-30.
https://hdl.handle.net/21.15107/rcub_rimi_1063

Ivanov M, Brkić P, Vajić UJ, Mihailović-Stanojević N, Milačić D, Jovović Đ, Karanović D, Đelić M, Jeremić R, Miloradović Z. Hyperbaric oxygenation protects the kidney against ischemia-reperfusion injury. in Undersea & hyperbaric medicine : journal of the Undersea & Hyperbaric Medical Society, Inc. 2020;47(1):21-30.
https://hdl.handle.net/21.15107/rcub_rimi_1063 .

Ivanov, Milan, Brkić, Predrag, Vajić, Una Jovana, Mihailović-Stanojević, Nevena, Milačić, Davorka, Jovović, Đurđica, Karanović, Danijela, Đelić, Marina, Jeremić, Rada, Miloradović, Zoran, "Hyperbaric oxygenation protects the kidney against ischemia-reperfusion injury" in Undersea & hyperbaric medicine : journal of the Undersea & Hyperbaric Medical Society, Inc, 47, no. 1 (2020):21-30,
https://hdl.handle.net/21.15107/rcub_rimi_1063 .

TY  - JOUR
AU  - Dominović-Kovačević, Aleksandra
AU  - Račić, Duško
AU  - Grgić, Sanja
AU  - Vukojević, Zoran
AU  - Milanović, Slađan
AU  - Ilić, Tihomir V.
PY  - 2018
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/901
AB  - Diagnosis of amyotrophic lateral sclerosis (ALS) is based on combination of clinical signs and electrophysiological correlates of pathological process which takes place in general. New electrophysiological criteria Awaji-Shima (AS) additionally qualify the complex fasciculations and neurogenically modified potentials of motor units as signs of active lesions of peripheral motor neuron, contrary to previously valid revised El Escorial criteria (rEE). The objective of this research was to determine the clinical significance and advantages of using the AS criteria in patients with ALS. Methods. Thirty patients (59.2 ± 10.9 years, 57% of them with spinal form of the disease) with clinically suspected ALS were monitored from the time of diagnosis until reaching the category of definitive diagnosis or death. The clinical evaluation and electromyographic (EMG) examinations were carried out at 3-month intervals. Results. By applying the AS criteria, the category of probable or definite diagnosis was achieved in all patients with ALS, except in one (96.6%), as contrary to the rEE (33.3%), after 6 months of the follow-up period. The subclinical affection in more than two body regions has been defined through detection of denervation potentials (80% of the patients by using the AS, or 67% by the rEE criteria). The complex fasciculations were registered particularly often in small muscles of the feet (37- 40%). Conclusion. Application of the AS criteria improve the achievment of category of probable or definite diagnosis of ALS by 2.7 months earlier compared to the rEE. This outcome is particularly affected by a higher frequency of positive EMG findings, when the AS criteria were employed. Early determination of diagnosis provides the better perspective and more frequent participation of the ALS patients in pharmacotherapy studies intended to establish new therapeutic options.
AB  - Dijagnoza amiotrofične lateralne skleroze (LS) zasniva se na kombinaciji kliničkih znakova i elektrofizioloških korelata patološkog procesa koji se odvija u osnovi. Novi elektrofiziološki kriterijumi, Awaji-Shima (AS), dodatno kvalifikuju kompleksne fascikulacije i neurogeno izmenjene potencijale motornih jedinica kao znakove aktivnih lezija perifernog motornog neurona, nasuprot ranije važećim revidiranim El Escorial kriterijumima (rEE). Cilj ovog istraživanja bio je da se utvrdi klinički značaj i prednosti primene AS kriterijuma, kod obolelih od ALS. Metode. 30 bolesnika (59,2 ± 10,9 godina, od kojih 57% sa spinalnom formom bolesti) sa klinički suspektnom ALS, praćeno je od vremena postavljanja dijagnoze do postizanja kategorije definitivne dijagnoze ili smrtnog ishoda. Kod bolesnika su obavljane klinička evaluacija i elektromiografski (EMG) pregledi u tromesečnim intervalima. Rezultati. Primjenom AS kriterijuma, nakon 6 meseci praćenja, kategorija verovatne ili pouzdane dijagnoze postignuta je kod svih bolesnika sa ALS, izuzev jednog (96,6%), nasuprot rEE kriterijuma (33.3%). EMG nalazi bili su pozitivni u ≥ 2 telesna regiona kod 80% bolesnika primenom AS, odnosno 67% primenom rEE. Kompleksne fascikulacije zabeležene su posebno učestalo u malim mišićima stopala (37-40%). Zaključak. Primenom AS kriterijuma kategorija vjerovatne ili pouzdane dijagnoze ALS postiže se za 2,7 meseca ranije, u poređenju sa rEE, na šta posebno utiče veća učestalost pozitivnih EMG nalaza. Ranije utvrđivanje dijagnoze donosi perspektivu veće zastupljenosti obolelih u farmakoterapijskim studijama sa novim terapeutskim agensima.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Comparison of diagnostic criteria in patients with amyotrophic lateral sclerosis: The contribution of electromyographic findings
T1  - Poređenje dijagnostičkih kriterijuma kod bolesnika sa amiotrofičnom lateralnom sklerozom - doprinos elektromiografskih nalaza
EP  - 446
IS  - 5
SP  - 439
VL  - 75
DO  - 10.2298/VSP160115330D
ER  - 

@article{
author = "Dominović-Kovačević, Aleksandra and Račić, Duško and Grgić, Sanja and Vukojević, Zoran and Milanović, Slađan and Ilić, Tihomir V.",
year = "2018",
abstract = "Diagnosis of amyotrophic lateral sclerosis (ALS) is based on combination of clinical signs and electrophysiological correlates of pathological process which takes place in general. New electrophysiological criteria Awaji-Shima (AS) additionally qualify the complex fasciculations and neurogenically modified potentials of motor units as signs of active lesions of peripheral motor neuron, contrary to previously valid revised El Escorial criteria (rEE). The objective of this research was to determine the clinical significance and advantages of using the AS criteria in patients with ALS. Methods. Thirty patients (59.2 ± 10.9 years, 57% of them with spinal form of the disease) with clinically suspected ALS were monitored from the time of diagnosis until reaching the category of definitive diagnosis or death. The clinical evaluation and electromyographic (EMG) examinations were carried out at 3-month intervals. Results. By applying the AS criteria, the category of probable or definite diagnosis was achieved in all patients with ALS, except in one (96.6%), as contrary to the rEE (33.3%), after 6 months of the follow-up period. The subclinical affection in more than two body regions has been defined through detection of denervation potentials (80% of the patients by using the AS, or 67% by the rEE criteria). The complex fasciculations were registered particularly often in small muscles of the feet (37- 40%). Conclusion. Application of the AS criteria improve the achievment of category of probable or definite diagnosis of ALS by 2.7 months earlier compared to the rEE. This outcome is particularly affected by a higher frequency of positive EMG findings, when the AS criteria were employed. Early determination of diagnosis provides the better perspective and more frequent participation of the ALS patients in pharmacotherapy studies intended to establish new therapeutic options., Dijagnoza amiotrofične lateralne skleroze (LS) zasniva se na kombinaciji kliničkih znakova i elektrofizioloških korelata patološkog procesa koji se odvija u osnovi. Novi elektrofiziološki kriterijumi, Awaji-Shima (AS), dodatno kvalifikuju kompleksne fascikulacije i neurogeno izmenjene potencijale motornih jedinica kao znakove aktivnih lezija perifernog motornog neurona, nasuprot ranije važećim revidiranim El Escorial kriterijumima (rEE). Cilj ovog istraživanja bio je da se utvrdi klinički značaj i prednosti primene AS kriterijuma, kod obolelih od ALS. Metode. 30 bolesnika (59,2 ± 10,9 godina, od kojih 57% sa spinalnom formom bolesti) sa klinički suspektnom ALS, praćeno je od vremena postavljanja dijagnoze do postizanja kategorije definitivne dijagnoze ili smrtnog ishoda. Kod bolesnika su obavljane klinička evaluacija i elektromiografski (EMG) pregledi u tromesečnim intervalima. Rezultati. Primjenom AS kriterijuma, nakon 6 meseci praćenja, kategorija verovatne ili pouzdane dijagnoze postignuta je kod svih bolesnika sa ALS, izuzev jednog (96,6%), nasuprot rEE kriterijuma (33.3%). EMG nalazi bili su pozitivni u ≥ 2 telesna regiona kod 80% bolesnika primenom AS, odnosno 67% primenom rEE. Kompleksne fascikulacije zabeležene su posebno učestalo u malim mišićima stopala (37-40%). Zaključak. Primenom AS kriterijuma kategorija vjerovatne ili pouzdane dijagnoze ALS postiže se za 2,7 meseca ranije, u poređenju sa rEE, na šta posebno utiče veća učestalost pozitivnih EMG nalaza. Ranije utvrđivanje dijagnoze donosi perspektivu veće zastupljenosti obolelih u farmakoterapijskim studijama sa novim terapeutskim agensima.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Comparison of diagnostic criteria in patients with amyotrophic lateral sclerosis: The contribution of electromyographic findings, Poređenje dijagnostičkih kriterijuma kod bolesnika sa amiotrofičnom lateralnom sklerozom - doprinos elektromiografskih nalaza",
pages = "446-439",
number = "5",
volume = "75",
doi = "10.2298/VSP160115330D"
}

Dominović-Kovačević, A., Račić, D., Grgić, S., Vukojević, Z., Milanović, S.,& Ilić, T. V.. (2018). Comparison of diagnostic criteria in patients with amyotrophic lateral sclerosis: The contribution of electromyographic findings. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 75(5), 439-446.
https://doi.org/10.2298/VSP160115330D

Dominović-Kovačević A, Račić D, Grgić S, Vukojević Z, Milanović S, Ilić TV. Comparison of diagnostic criteria in patients with amyotrophic lateral sclerosis: The contribution of electromyographic findings. in Vojnosanitetski pregled. 2018;75(5):439-446.
doi:10.2298/VSP160115330D .

Dominović-Kovačević, Aleksandra, Račić, Duško, Grgić, Sanja, Vukojević, Zoran, Milanović, Slađan, Ilić, Tihomir V., "Comparison of diagnostic criteria in patients with amyotrophic lateral sclerosis: The contribution of electromyographic findings" in Vojnosanitetski pregled, 75, no. 5 (2018):439-446,
https://doi.org/10.2298/VSP160115330D . .

TY  - JOUR
AU  - Cvetković, Zorica
AU  - Milošević, Maja
AU  - Cvetković, Bora
AU  - Masnikosa, Romana
AU  - Arsić, Aleksandra
AU  - Petrović, Snježana
AU  - Vučić, Vesna M.
PY  - 2017
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/797
AB  - Limited studies have been performed to associate abnormal phospholipid (PL) profile and disease activity in hematological malignancies, including non-Hodgkin lymphoma (NHL). The aim of his study was to evaluate the levels of plasma PL fractions in NHL patients, in response to chemotherapy. Forty non-treated patients with NHL and 25 healthy individuals were recruited. Blood samples from patients were taken before chemotherapy, after 3 cycles and after the end of the treatment, and PL fractions were resolved by one-dimensional thin-layer chromatography. To assess potential relationship between plasma PL profile and response to therapy, patients were divided according to clinical outcome in 3 groups: complete remission (CR), stable disease (SD) and progression (PG). Despite significant differences between NHL patients and healthy controls, no differences were found at baseline among patients divided according to clinical outcome. During and after chemotherapy important alterations in PL profile were observed. Levels of total PLs and all PL fractions decreased in patients with PG while in patients who responded to therapy (CR, SD) PLs significantly increased. Results of our study suggest that changes of total PLs and PL fractions during the therapy are associated with the effects of therapy and clinical outcome in patients with NHL.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Leukemia Research
T1  - Plasma phospholipid changes are associated with response to chemotherapy in non-Hodgkin lymphoma patients
EP  - 46
SP  - 39
VL  - 54
DO  - 10.1016/j.leukres.2017.01.004
ER  - 

@article{
author = "Cvetković, Zorica and Milošević, Maja and Cvetković, Bora and Masnikosa, Romana and Arsić, Aleksandra and Petrović, Snježana and Vučić, Vesna M.",
year = "2017",
abstract = "Limited studies have been performed to associate abnormal phospholipid (PL) profile and disease activity in hematological malignancies, including non-Hodgkin lymphoma (NHL). The aim of his study was to evaluate the levels of plasma PL fractions in NHL patients, in response to chemotherapy. Forty non-treated patients with NHL and 25 healthy individuals were recruited. Blood samples from patients were taken before chemotherapy, after 3 cycles and after the end of the treatment, and PL fractions were resolved by one-dimensional thin-layer chromatography. To assess potential relationship between plasma PL profile and response to therapy, patients were divided according to clinical outcome in 3 groups: complete remission (CR), stable disease (SD) and progression (PG). Despite significant differences between NHL patients and healthy controls, no differences were found at baseline among patients divided according to clinical outcome. During and after chemotherapy important alterations in PL profile were observed. Levels of total PLs and all PL fractions decreased in patients with PG while in patients who responded to therapy (CR, SD) PLs significantly increased. Results of our study suggest that changes of total PLs and PL fractions during the therapy are associated with the effects of therapy and clinical outcome in patients with NHL.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Leukemia Research",
title = "Plasma phospholipid changes are associated with response to chemotherapy in non-Hodgkin lymphoma patients",
pages = "46-39",
volume = "54",
doi = "10.1016/j.leukres.2017.01.004"
}

Cvetković, Z., Milošević, M., Cvetković, B., Masnikosa, R., Arsić, A., Petrović, S.,& Vučić, V. M.. (2017). Plasma phospholipid changes are associated with response to chemotherapy in non-Hodgkin lymphoma patients. in Leukemia Research
Pergamon-Elsevier Science Ltd, Oxford., 54, 39-46.
https://doi.org/10.1016/j.leukres.2017.01.004

Cvetković Z, Milošević M, Cvetković B, Masnikosa R, Arsić A, Petrović S, Vučić VM. Plasma phospholipid changes are associated with response to chemotherapy in non-Hodgkin lymphoma patients. in Leukemia Research. 2017;54:39-46.
doi:10.1016/j.leukres.2017.01.004 .

Cvetković, Zorica, Milošević, Maja, Cvetković, Bora, Masnikosa, Romana, Arsić, Aleksandra, Petrović, Snježana, Vučić, Vesna M., "Plasma phospholipid changes are associated with response to chemotherapy in non-Hodgkin lymphoma patients" in Leukemia Research, 54 (2017):39-46,
https://doi.org/10.1016/j.leukres.2017.01.004 . .

TY  - JOUR
AU  - Drljačić, Dragana
AU  - Pajić, Sanja
AU  - Nedeljković, Aleksandar
AU  - Milanović, Slađan
AU  - Ilić, Tihomir V.
PY  - 2017
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/810
AB  - Background/Aim. Adaptive control and fingertip force synchronization of precise grasp stability during unimanual manipulation of small objects represents an illustrative example of highly fractionated movements that are foundation of fine motor control. It is assumed that this process is controlled by several motor areas of the frontal lobe, particularly applicable to the primary motor (M-1) and dorsal premotor cortex (PMd). Aiming to examine the role of PMd during fine coordination of fingertip forces we applied theta burst repetitive magnetic stimulation (TBS) to disrupt neural processing in that cortical area. Methods. Using a single-blind, randomized, crossover design, 10 healthy subjects (29 ± 3.9 years) received single sessions of continuous TBS (cTBS600), intermittent TBS (iTBS600), or sham stimulation, separate from one another at least one week, over the PMd region of dominant hemisphere. Precision grasp and lift were assessed by instrumented device, recording grip (G) and load (L) forces, during three manipulation tasks (ramp-and-hold, oscillation force producing and simple lifting tasks), with each hand separately, before and after interventions. Results. We observed the improvement of task performance related to constant error (CE) in oscillation task with the dominant hand (DH) after the iTBS (p = 0.009). On the contrary, the cTBS reduced variable error (VE) for non-dominant hand (NH), p = 0.005. Considering force coordination we found that iTBS worsened variables for NH (G/L ratio, p = 0.017; cross-correlation of the G and L, p = 0.047; Gain, p = 0.047). Conclusion. These results demonstrate the ability of TBS to modulate fingertip forces during precision grasping and lifting, when applied over PMd. These findings support the role of PMd in human motor control and forces generation required to hold small objects stable in our hands.
AB  - Uvod/Cilj. Adaptivna kontrola i sinhronizacija sila prstiju šake tokom preciznog hvata pri manipulisanju malim predmetima jednom rukom predstavlja ilustrativni primer visoko frakcionisanih pokreta koji predstavljaju temelj motorne kontrole preciznih pokreta. Pretpostavlja se da ovim procesom upravlja nekoliko motornih oblasti frontalnog režnja, i to prvenstveno primarni motorni (M-1) i dorzalni premotorni korteks (PMd). Cilj istraživanja bio je ispitivanje uloge PMd-a tokom vršenja pokreta koji zahtevaju finu koordinaciju sila prstiju šake. U istraživanju smo primenili ponavljanu magnetnu stimulaciju pražnjenjima u teta frekvenciji, kako bi ometali neuralno procesiranje u toj oblasti moždane kore. Metode. Primenom jednostrano slepe studije, uz nasumičnu raspodelu i ukršteni dizajn, 10 zdravih ispitanika (29 ± 3,9 godina) bilo je izloženo pojedinačnim sesijama kontinuirane magnetne stimulacije (cTBS600), ili intermitentne ponavljane magnetne stimulacije (iTBS600), pražnjenjima u teta frekvenciji kao i prividnoj stimulaciji iznad PMd regiona dominantne hemisfere, odvojenih međusobno, najkraće nedelju dana. Precizanost hvata šake i podizanja procenjivani su uređajem koji je registrovao silu stiska (G) i silu podizanja (L) prilikom izvođenja tri zadatka (zadatak sa zadatim profilom L, zadatak sa oscilatornim variranjem nivoa L i zadatak sa podizanjem), koji su izvođeni sa obe ruke odvojeno, i to pre i nakon svake intervencije. Rezultati. Nakon primene iTBS protokola zabeleženo je poboljšanje izvođenja iskazano konstantnom greškom (CE) u zadatku sa oscilatornim variranjem nivoa L, kada je izvođen dominantnom rukom (DH), p = 0.009. Suprotno tome, primena cTBS protokola dovela je do smanjenja promenjive greške (VE) za nedominantnu ruku (NH), p = 0.005. Sa aspekta koordinacije sila utvrđeno je da je iTBS protokol doveo do pogoršanja rezultata praćenih pokazatelja za nedominantnu ruku (G/L odnos, p = 0.017; korelacija G i L, p = 0.047; prirast sile p = 0.047). Zaključak. Rezultati našeg istraživanja ukazuju na mogućnost modulacije sila prstiju šake tokom preciznog hvata i podizanja, ukoliko se TBS primeni iznad PMd-a. Dobijeni nalazi podržavaju ulogu PMd u motornoj kontroli i generisanju sila neophodnih za stabilno držanje malih predmeta kod ljudi.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Complex modulation of fingertip forces during precision grasp and lift after theta burst stimulation over the dorsal premotor cortex
T1  - Kompleksna modulacija sila tokom preciznog hvata šake primenom ponavljane transkranijalne magnetne stimulacije pražnjenjima u teta frekvenciji iznad dorzalnog premotornog korteksa
EP  - 535
IS  - 6
SP  - 526
VL  - 74
DO  - 10.2298/VSP151120249D
ER  - 

@article{
author = "Drljačić, Dragana and Pajić, Sanja and Nedeljković, Aleksandar and Milanović, Slađan and Ilić, Tihomir V.",
year = "2017",
abstract = "Background/Aim. Adaptive control and fingertip force synchronization of precise grasp stability during unimanual manipulation of small objects represents an illustrative example of highly fractionated movements that are foundation of fine motor control. It is assumed that this process is controlled by several motor areas of the frontal lobe, particularly applicable to the primary motor (M-1) and dorsal premotor cortex (PMd). Aiming to examine the role of PMd during fine coordination of fingertip forces we applied theta burst repetitive magnetic stimulation (TBS) to disrupt neural processing in that cortical area. Methods. Using a single-blind, randomized, crossover design, 10 healthy subjects (29 ± 3.9 years) received single sessions of continuous TBS (cTBS600), intermittent TBS (iTBS600), or sham stimulation, separate from one another at least one week, over the PMd region of dominant hemisphere. Precision grasp and lift were assessed by instrumented device, recording grip (G) and load (L) forces, during three manipulation tasks (ramp-and-hold, oscillation force producing and simple lifting tasks), with each hand separately, before and after interventions. Results. We observed the improvement of task performance related to constant error (CE) in oscillation task with the dominant hand (DH) after the iTBS (p = 0.009). On the contrary, the cTBS reduced variable error (VE) for non-dominant hand (NH), p = 0.005. Considering force coordination we found that iTBS worsened variables for NH (G/L ratio, p = 0.017; cross-correlation of the G and L, p = 0.047; Gain, p = 0.047). Conclusion. These results demonstrate the ability of TBS to modulate fingertip forces during precision grasping and lifting, when applied over PMd. These findings support the role of PMd in human motor control and forces generation required to hold small objects stable in our hands., Uvod/Cilj. Adaptivna kontrola i sinhronizacija sila prstiju šake tokom preciznog hvata pri manipulisanju malim predmetima jednom rukom predstavlja ilustrativni primer visoko frakcionisanih pokreta koji predstavljaju temelj motorne kontrole preciznih pokreta. Pretpostavlja se da ovim procesom upravlja nekoliko motornih oblasti frontalnog režnja, i to prvenstveno primarni motorni (M-1) i dorzalni premotorni korteks (PMd). Cilj istraživanja bio je ispitivanje uloge PMd-a tokom vršenja pokreta koji zahtevaju finu koordinaciju sila prstiju šake. U istraživanju smo primenili ponavljanu magnetnu stimulaciju pražnjenjima u teta frekvenciji, kako bi ometali neuralno procesiranje u toj oblasti moždane kore. Metode. Primenom jednostrano slepe studije, uz nasumičnu raspodelu i ukršteni dizajn, 10 zdravih ispitanika (29 ± 3,9 godina) bilo je izloženo pojedinačnim sesijama kontinuirane magnetne stimulacije (cTBS600), ili intermitentne ponavljane magnetne stimulacije (iTBS600), pražnjenjima u teta frekvenciji kao i prividnoj stimulaciji iznad PMd regiona dominantne hemisfere, odvojenih međusobno, najkraće nedelju dana. Precizanost hvata šake i podizanja procenjivani su uređajem koji je registrovao silu stiska (G) i silu podizanja (L) prilikom izvođenja tri zadatka (zadatak sa zadatim profilom L, zadatak sa oscilatornim variranjem nivoa L i zadatak sa podizanjem), koji su izvođeni sa obe ruke odvojeno, i to pre i nakon svake intervencije. Rezultati. Nakon primene iTBS protokola zabeleženo je poboljšanje izvođenja iskazano konstantnom greškom (CE) u zadatku sa oscilatornim variranjem nivoa L, kada je izvođen dominantnom rukom (DH), p = 0.009. Suprotno tome, primena cTBS protokola dovela je do smanjenja promenjive greške (VE) za nedominantnu ruku (NH), p = 0.005. Sa aspekta koordinacije sila utvrđeno je da je iTBS protokol doveo do pogoršanja rezultata praćenih pokazatelja za nedominantnu ruku (G/L odnos, p = 0.017; korelacija G i L, p = 0.047; prirast sile p = 0.047). Zaključak. Rezultati našeg istraživanja ukazuju na mogućnost modulacije sila prstiju šake tokom preciznog hvata i podizanja, ukoliko se TBS primeni iznad PMd-a. Dobijeni nalazi podržavaju ulogu PMd u motornoj kontroli i generisanju sila neophodnih za stabilno držanje malih predmeta kod ljudi.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Complex modulation of fingertip forces during precision grasp and lift after theta burst stimulation over the dorsal premotor cortex, Kompleksna modulacija sila tokom preciznog hvata šake primenom ponavljane transkranijalne magnetne stimulacije pražnjenjima u teta frekvenciji iznad dorzalnog premotornog korteksa",
pages = "535-526",
number = "6",
volume = "74",
doi = "10.2298/VSP151120249D"
}

Drljačić, D., Pajić, S., Nedeljković, A., Milanović, S.,& Ilić, T. V.. (2017). Complex modulation of fingertip forces during precision grasp and lift after theta burst stimulation over the dorsal premotor cortex. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 74(6), 526-535.
https://doi.org/10.2298/VSP151120249D

Drljačić D, Pajić S, Nedeljković A, Milanović S, Ilić TV. Complex modulation of fingertip forces during precision grasp and lift after theta burst stimulation over the dorsal premotor cortex. in Vojnosanitetski pregled. 2017;74(6):526-535.
doi:10.2298/VSP151120249D .

Drljačić, Dragana, Pajić, Sanja, Nedeljković, Aleksandar, Milanović, Slađan, Ilić, Tihomir V., "Complex modulation of fingertip forces during precision grasp and lift after theta burst stimulation over the dorsal premotor cortex" in Vojnosanitetski pregled, 74, no. 6 (2017):526-535,
https://doi.org/10.2298/VSP151120249D . .

TY  - JOUR
AU  - Ilić, Nela V.
AU  - Dubljanin-Raspopović, Emilija
AU  - Nedeljković, Una
AU  - Tomanovic-Vujadinović, Sanja
AU  - Milanović, Slađan
AU  - Petronic-Marković, Ivana
AU  - Ilić, Tihomir V.
PY  - 2016
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/711
AB  - Background: A growing body of evidence supports the effectiveness of using transcranial direct current stimulation (tDCS) in patients with chronic hand motor impairment resulting from stroke. Objective: In this study, we investigate and compare the combined effects of anodal tDCS and occupational therapy (OT) to sham stimulation with OT (control) on fine motor skill deficits of chronic stroke patients. Methods: A total of 26 stroke patients (at  gt = 9 months) were randomly assigned to an active treatment or a control group in a double-blinded, sham-controlled, parallel design study. Each group received OT for 45 min/day (10 sessions for 2 weeks). Treatment was preceded by either 20 minutes of 2mA anodal tDCS over ipsilesional M1 or sham tDCS. A modified Jebsen-Taylor Hand Function Test (mJTHFT) was administered as primary outcome measure, and handgrip dynamometer and upper limb Fugl-Meyer (ULFM) assessments were performed as secondary outcomes. The assessment was done at baseline (T0), after the interventions on day 1(T1), day 10 (T2) and day 40 (T3). Results: We observed a statistically significant effect in the tDCS group when the results were compared to the sham group. The mJTHFT times were significantly shorter immediately after treatment and at day 40. The intervention had no effect on handgrip strength or ULFM score. Conclusion: Fine motor skill deficits in chronic stroke survivors can be improved when intensive OT is primed with anodal tDCS over the ipsilesional hemisphere.
PB  - Ios Press, Amsterdam
T2  - Restorative Neurology & Neuroscience
T1  - Effects of anodal tDCS and occupational therapy on fine motor skill deficits in patients with chronic stroke
EP  - 945
IS  - 6
SP  - 935
VL  - 34
DO  - 10.3233/RNN-160668
ER  - 

@article{
author = "Ilić, Nela V. and Dubljanin-Raspopović, Emilija and Nedeljković, Una and Tomanovic-Vujadinović, Sanja and Milanović, Slađan and Petronic-Marković, Ivana and Ilić, Tihomir V.",
year = "2016",
abstract = "Background: A growing body of evidence supports the effectiveness of using transcranial direct current stimulation (tDCS) in patients with chronic hand motor impairment resulting from stroke. Objective: In this study, we investigate and compare the combined effects of anodal tDCS and occupational therapy (OT) to sham stimulation with OT (control) on fine motor skill deficits of chronic stroke patients. Methods: A total of 26 stroke patients (at  gt = 9 months) were randomly assigned to an active treatment or a control group in a double-blinded, sham-controlled, parallel design study. Each group received OT for 45 min/day (10 sessions for 2 weeks). Treatment was preceded by either 20 minutes of 2mA anodal tDCS over ipsilesional M1 or sham tDCS. A modified Jebsen-Taylor Hand Function Test (mJTHFT) was administered as primary outcome measure, and handgrip dynamometer and upper limb Fugl-Meyer (ULFM) assessments were performed as secondary outcomes. The assessment was done at baseline (T0), after the interventions on day 1(T1), day 10 (T2) and day 40 (T3). Results: We observed a statistically significant effect in the tDCS group when the results were compared to the sham group. The mJTHFT times were significantly shorter immediately after treatment and at day 40. The intervention had no effect on handgrip strength or ULFM score. Conclusion: Fine motor skill deficits in chronic stroke survivors can be improved when intensive OT is primed with anodal tDCS over the ipsilesional hemisphere.",
publisher = "Ios Press, Amsterdam",
journal = "Restorative Neurology & Neuroscience",
title = "Effects of anodal tDCS and occupational therapy on fine motor skill deficits in patients with chronic stroke",
pages = "945-935",
number = "6",
volume = "34",
doi = "10.3233/RNN-160668"
}

Ilić, N. V., Dubljanin-Raspopović, E., Nedeljković, U., Tomanovic-Vujadinović, S., Milanović, S., Petronic-Marković, I.,& Ilić, T. V.. (2016). Effects of anodal tDCS and occupational therapy on fine motor skill deficits in patients with chronic stroke. in Restorative Neurology & Neuroscience
Ios Press, Amsterdam., 34(6), 935-945.
https://doi.org/10.3233/RNN-160668

Ilić NV, Dubljanin-Raspopović E, Nedeljković U, Tomanovic-Vujadinović S, Milanović S, Petronic-Marković I, Ilić TV. Effects of anodal tDCS and occupational therapy on fine motor skill deficits in patients with chronic stroke. in Restorative Neurology & Neuroscience. 2016;34(6):935-945.
doi:10.3233/RNN-160668 .

Ilić, Nela V., Dubljanin-Raspopović, Emilija, Nedeljković, Una, Tomanovic-Vujadinović, Sanja, Milanović, Slađan, Petronic-Marković, Ivana, Ilić, Tihomir V., "Effects of anodal tDCS and occupational therapy on fine motor skill deficits in patients with chronic stroke" in Restorative Neurology & Neuroscience, 34, no. 6 (2016):935-945,
https://doi.org/10.3233/RNN-160668 . .

TY  - THES
AU  - Milošević, Maja
PY  - 2014
UR  - http://nardus.mpn.gov.rs/handle/123456789/6382
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=3654
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:12456/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=48111119
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1097
AB  - ATP and other purine nucleotides are paracrine signaling molecules. Acting via purine receptors (P1 and P2) on the cell membrane, extracellular nucleotides participate in the control of contraction and modulation of the immune response in mammalian uterus. Disorder of uterine contractility may play an important role in the development of infertility, dysmenorrhea and premature labor. In this study, we examined the presence and kinetic properties of ectoenzymes that hydrolyze extracellular ATP and ADP in rat uterus (Wistar albino). Also, effects of heavy metal ions (cadmium, mercury, and copper) on the activity of ectoenzymes from rat uterus were studied in vitro, in the absence and presence of EDTA and L-cysteine. This study showed that hydrolysis of extracellular ATP and ADP in rat uterus is catalyzed by enzymes classified as the E-NTPDase family. The following results confirmed common properties characteristic for E-NTPDases: insensitivity to inhibitors of other membrane ATPase (oligomycin, ouabain, theophylline and levamisole), an alkaline pH optimum for both substrates (8.0-8.5), divalent cations dependence and significant inhibition by suramine. E-NTPDase activity in rat uterus appeared to be very high compared to other rat tissues. The apparent Km values were 0.506±0.062 and 0.639±0.031 mM, with a calculated Vmax (app) of 3.973±0.280 and 2.854±0.080 μmol Pi/min/mg for ATP and ADP, respectively. According to similar apparent Km values for both substrates, the ATP/ADP hydrolysis ratio (1:0:57), Chevillard competition plot, and inhibition by high milimolar concentrations of sodium-azide (5-10 mM), E-NTPDase 1 is dominant ATP/ADP hydrolyzing enzyme in uterine cell membranes. RT-PCR and Western blot analysis revealed gene and protein expression of NTPDaze 1 and 2 in rat uterus. In the further course of research, the effects and mechanism of action of divalent ions (mercury, cadmium and copper) on the activity of E-NTPDases from rat uterus were examined...
AB  - ATP i drugi purinski nukleotidi su parakrini signalni molekuli koji vezivanjem za purinske receptore (P1 i P2) na ćelijskoj membrani učestvuju u kontroli kontrakcija i modulaciji imunog odgovora u uterusu sisara. Poremećaji kontraktilnosti uterusa mogu imati važnu ulogu u nastanku neplodnosti, dismenoreje i prevremenog porođaja. U ovom radu ispitano je prisustvo i kinetičke osobine ektoenzima koji hidrolizuju vanćelijski ATP i ADP u uterusu pacova (Wistar albino). Takođe, ispitan je in vitro uticaj teških metala (kadmijuma, žive i bakra) kao i zaštitni efekat EDTA i L-cisteina na aktivnost ektoenzima u prisustvu jona metala. Rezultati ove studije pokazali su da hidrolizu vanćelijskog ATP i ADP u uterusu pacova katalizuju enzimi iz familije E-NTPDaza. To potvrđuju rezultati: neosetljivosti na inhibitore drugih membranskih ATPaza (oligomicin, ouabain, teofiln i levamisol); pH optimum za maksimalnu aktivnost enzima na alkalnom pH (8.0-8.5) za oba supstrata; zavisnost enzimske aktivnosti od dvovalentnih jona i inhibicija suraminom. Izmerana aktivnost E-NTPDaza u uterusu je veoma visoka u odnosu na ostala tkiva pacova, što se vidi iz dobijenih vrednosti kinetičkih parametara za hidrolizu ATP (Vmax (app)=3.973±0.280 μmol Pi/min/mg, Km (app)=0.506±0.062 mM), odnosno ADP (Vmax (app)=2.854±0.080 μmol Pi/min/mg, Km (app)=0.639±0.031 mM). Slične Km vrednosti za hidrolizu ATP i ADP, odnos početnih brzina hidrolize ATP/ADP (1:0.57), Chevillard-ova kriva kompeticije ATP i ADP, kao i inhibicija milimolarnim koncentracijama natrijum-azida (5-10 mM) ukazuju da je E-NTPDaza 1 dominantni enzim koji hidrolizuje vanćelijske nukleotide u uterusu pacova. RT-PCR i Western blot analizom pokazana je genska i proteinska ekspresija NTPDaze 1 i 2 u uterusu pacova. U daljem toku istraživanja ispitan je efekat i mehanizma delovanja dvovalentnih jona kadmijuma, žive(II) i bakra(II) na aktivnost E-NTPDaza iz uterusa pacova...
PB  - Univerzitet u Beogradu, Hemijski fakultet
T1  - Characterization of ectoenzymes that hydrolyze extracellular ATP and ADP in rat uterus and in vitro effects of cadmium, mercury and copper on enzyme activity
T1  - Karakterizacija ektoenzima koji hidrolizuju vanćelijski ATP i ADP u uterusu pacova i in vitro uticaj kadmijuma, žive i bakra na aktivnost enzima
UR  - https://hdl.handle.net/21.15107/rcub_nardus_6382
ER  - 

@phdthesis{
author = "Milošević, Maja",
year = "2014",
abstract = "ATP and other purine nucleotides are paracrine signaling molecules. Acting via purine receptors (P1 and P2) on the cell membrane, extracellular nucleotides participate in the control of contraction and modulation of the immune response in mammalian uterus. Disorder of uterine contractility may play an important role in the development of infertility, dysmenorrhea and premature labor. In this study, we examined the presence and kinetic properties of ectoenzymes that hydrolyze extracellular ATP and ADP in rat uterus (Wistar albino). Also, effects of heavy metal ions (cadmium, mercury, and copper) on the activity of ectoenzymes from rat uterus were studied in vitro, in the absence and presence of EDTA and L-cysteine. This study showed that hydrolysis of extracellular ATP and ADP in rat uterus is catalyzed by enzymes classified as the E-NTPDase family. The following results confirmed common properties characteristic for E-NTPDases: insensitivity to inhibitors of other membrane ATPase (oligomycin, ouabain, theophylline and levamisole), an alkaline pH optimum for both substrates (8.0-8.5), divalent cations dependence and significant inhibition by suramine. E-NTPDase activity in rat uterus appeared to be very high compared to other rat tissues. The apparent Km values were 0.506±0.062 and 0.639±0.031 mM, with a calculated Vmax (app) of 3.973±0.280 and 2.854±0.080 μmol Pi/min/mg for ATP and ADP, respectively. According to similar apparent Km values for both substrates, the ATP/ADP hydrolysis ratio (1:0:57), Chevillard competition plot, and inhibition by high milimolar concentrations of sodium-azide (5-10 mM), E-NTPDase 1 is dominant ATP/ADP hydrolyzing enzyme in uterine cell membranes. RT-PCR and Western blot analysis revealed gene and protein expression of NTPDaze 1 and 2 in rat uterus. In the further course of research, the effects and mechanism of action of divalent ions (mercury, cadmium and copper) on the activity of E-NTPDases from rat uterus were examined..., ATP i drugi purinski nukleotidi su parakrini signalni molekuli koji vezivanjem za purinske receptore (P1 i P2) na ćelijskoj membrani učestvuju u kontroli kontrakcija i modulaciji imunog odgovora u uterusu sisara. Poremećaji kontraktilnosti uterusa mogu imati važnu ulogu u nastanku neplodnosti, dismenoreje i prevremenog porođaja. U ovom radu ispitano je prisustvo i kinetičke osobine ektoenzima koji hidrolizuju vanćelijski ATP i ADP u uterusu pacova (Wistar albino). Takođe, ispitan je in vitro uticaj teških metala (kadmijuma, žive i bakra) kao i zaštitni efekat EDTA i L-cisteina na aktivnost ektoenzima u prisustvu jona metala. Rezultati ove studije pokazali su da hidrolizu vanćelijskog ATP i ADP u uterusu pacova katalizuju enzimi iz familije E-NTPDaza. To potvrđuju rezultati: neosetljivosti na inhibitore drugih membranskih ATPaza (oligomicin, ouabain, teofiln i levamisol); pH optimum za maksimalnu aktivnost enzima na alkalnom pH (8.0-8.5) za oba supstrata; zavisnost enzimske aktivnosti od dvovalentnih jona i inhibicija suraminom. Izmerana aktivnost E-NTPDaza u uterusu je veoma visoka u odnosu na ostala tkiva pacova, što se vidi iz dobijenih vrednosti kinetičkih parametara za hidrolizu ATP (Vmax (app)=3.973±0.280 μmol Pi/min/mg, Km (app)=0.506±0.062 mM), odnosno ADP (Vmax (app)=2.854±0.080 μmol Pi/min/mg, Km (app)=0.639±0.031 mM). Slične Km vrednosti za hidrolizu ATP i ADP, odnos početnih brzina hidrolize ATP/ADP (1:0.57), Chevillard-ova kriva kompeticije ATP i ADP, kao i inhibicija milimolarnim koncentracijama natrijum-azida (5-10 mM) ukazuju da je E-NTPDaza 1 dominantni enzim koji hidrolizuje vanćelijske nukleotide u uterusu pacova. RT-PCR i Western blot analizom pokazana je genska i proteinska ekspresija NTPDaze 1 i 2 u uterusu pacova. U daljem toku istraživanja ispitan je efekat i mehanizma delovanja dvovalentnih jona kadmijuma, žive(II) i bakra(II) na aktivnost E-NTPDaza iz uterusa pacova...",
publisher = "Univerzitet u Beogradu, Hemijski fakultet",
title = "Characterization of ectoenzymes that hydrolyze extracellular ATP and ADP in rat uterus and in vitro effects of cadmium, mercury and copper on enzyme activity, Karakterizacija ektoenzima koji hidrolizuju vanćelijski ATP i ADP u uterusu pacova i in vitro uticaj kadmijuma, žive i bakra na aktivnost enzima",
url = "https://hdl.handle.net/21.15107/rcub_nardus_6382"
}

Milošević, M.. (2014). Characterization of ectoenzymes that hydrolyze extracellular ATP and ADP in rat uterus and in vitro effects of cadmium, mercury and copper on enzyme activity. 
Univerzitet u Beogradu, Hemijski fakultet..
https://hdl.handle.net/21.15107/rcub_nardus_6382

Milošević M. Characterization of ectoenzymes that hydrolyze extracellular ATP and ADP in rat uterus and in vitro effects of cadmium, mercury and copper on enzyme activity. 2014;.
https://hdl.handle.net/21.15107/rcub_nardus_6382 .

Milošević, Maja, "Characterization of ectoenzymes that hydrolyze extracellular ATP and ADP in rat uterus and in vitro effects of cadmium, mercury and copper on enzyme activity" (2014),
https://hdl.handle.net/21.15107/rcub_nardus_6382 .

TY  - JOUR
AU  - Krstić, Jelena
AU  - Buzadzić, Ivana
AU  - Milanović, Slađan
AU  - Ilić, Nela V.
AU  - Pajić, Sanja
AU  - Ilić, Tihomir V.
PY  - 2014
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/563
AB  - Introduction: Sham-controlled low-frequency repetitive transcranial magnetic stimulation (rTMS) was used in patients with pharmacoresistant major depression as an added treatment along with partial sleep deprivation (PSD). In addition, the potential predictive role of brain-derived neurotrophic factor genetic polymorphism on treatment response was analyzed. Methods: We recruited 19 female patients (48.3 +/- 8.6 years old) with treatment-resistant unipolar major depression (Hamilton Depression Rating Scale [HDRS] score  gt = 20) who were on a stable antidepressant treatment. They received either 1-Hz rTMS or sham stimulation over the right dorsolateral prefrontal cortex (intensity of 110% of the threshold; 3000 stimuli per protocol; and 10 daily sessions). Additionally, PSD was applied once per week during the treatment. The patients were evaluated (HDRS and Clinical Global Impression Scale) by a blind rater at baseline (B) and after 2 and 3 weeks (W2 and W3) of treatment for short-term outcome. Long-term evaluations were performed after 12 (W12) and 24 weeks (W24) for patients who received active stimulation. Results: Eleven patients in the active group showed a significant HDRS score reduction from 30.09 +/- 3.53 (B) to 16.73 +/- 5.71 (W3) compared to the lack of therapeutic response in the sham-treated patients. The long-term follow-up for the active group included 64% of the responders at W12 and 55% at W24. Full remission (HDRS  lt = 10) was achieved in 5 of 11 patients. Four of these 5 patients with long-term sustained remission expressed the Val66Val genotype. Conclusion: Our study suggests a clinically relevant response, persisting for up to 6 months, from 1-Hz rTMS over the right dorsolateral prefrontal cortex and PSD in patients with pharmacoresistant major depression. The brain-derived neurotrophic factor Val66Val homozygous genotype may be related to a better treatment outcome.
PB  - Lippincott Williams & Wilkins, Philadelphia
T2  - Journal of ECT
T1  - Low-Frequency Repetitive Transcranial Magnetic Stimulation in the Right Prefrontal Cortex Combined With Partial Sleep Deprivation in Treatment-Resistant Depression A Randomized Sham-Controlled Trial
EP  - 331
IS  - 4
SP  - 325
VL  - 30
DO  - 10.1097/YCT.0000000000000099
ER  - 

@article{
author = "Krstić, Jelena and Buzadzić, Ivana and Milanović, Slađan and Ilić, Nela V. and Pajić, Sanja and Ilić, Tihomir V.",
year = "2014",
abstract = "Introduction: Sham-controlled low-frequency repetitive transcranial magnetic stimulation (rTMS) was used in patients with pharmacoresistant major depression as an added treatment along with partial sleep deprivation (PSD). In addition, the potential predictive role of brain-derived neurotrophic factor genetic polymorphism on treatment response was analyzed. Methods: We recruited 19 female patients (48.3 +/- 8.6 years old) with treatment-resistant unipolar major depression (Hamilton Depression Rating Scale [HDRS] score  gt = 20) who were on a stable antidepressant treatment. They received either 1-Hz rTMS or sham stimulation over the right dorsolateral prefrontal cortex (intensity of 110% of the threshold; 3000 stimuli per protocol; and 10 daily sessions). Additionally, PSD was applied once per week during the treatment. The patients were evaluated (HDRS and Clinical Global Impression Scale) by a blind rater at baseline (B) and after 2 and 3 weeks (W2 and W3) of treatment for short-term outcome. Long-term evaluations were performed after 12 (W12) and 24 weeks (W24) for patients who received active stimulation. Results: Eleven patients in the active group showed a significant HDRS score reduction from 30.09 +/- 3.53 (B) to 16.73 +/- 5.71 (W3) compared to the lack of therapeutic response in the sham-treated patients. The long-term follow-up for the active group included 64% of the responders at W12 and 55% at W24. Full remission (HDRS  lt = 10) was achieved in 5 of 11 patients. Four of these 5 patients with long-term sustained remission expressed the Val66Val genotype. Conclusion: Our study suggests a clinically relevant response, persisting for up to 6 months, from 1-Hz rTMS over the right dorsolateral prefrontal cortex and PSD in patients with pharmacoresistant major depression. The brain-derived neurotrophic factor Val66Val homozygous genotype may be related to a better treatment outcome.",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Journal of ECT",
title = "Low-Frequency Repetitive Transcranial Magnetic Stimulation in the Right Prefrontal Cortex Combined With Partial Sleep Deprivation in Treatment-Resistant Depression A Randomized Sham-Controlled Trial",
pages = "331-325",
number = "4",
volume = "30",
doi = "10.1097/YCT.0000000000000099"
}

Krstić, J., Buzadzić, I., Milanović, S., Ilić, N. V., Pajić, S.,& Ilić, T. V.. (2014). Low-Frequency Repetitive Transcranial Magnetic Stimulation in the Right Prefrontal Cortex Combined With Partial Sleep Deprivation in Treatment-Resistant Depression A Randomized Sham-Controlled Trial. in Journal of ECT
Lippincott Williams & Wilkins, Philadelphia., 30(4), 325-331.
https://doi.org/10.1097/YCT.0000000000000099

Krstić J, Buzadzić I, Milanović S, Ilić NV, Pajić S, Ilić TV. Low-Frequency Repetitive Transcranial Magnetic Stimulation in the Right Prefrontal Cortex Combined With Partial Sleep Deprivation in Treatment-Resistant Depression A Randomized Sham-Controlled Trial. in Journal of ECT. 2014;30(4):325-331.
doi:10.1097/YCT.0000000000000099 .

Krstić, Jelena, Buzadzić, Ivana, Milanović, Slađan, Ilić, Nela V., Pajić, Sanja, Ilić, Tihomir V., "Low-Frequency Repetitive Transcranial Magnetic Stimulation in the Right Prefrontal Cortex Combined With Partial Sleep Deprivation in Treatment-Resistant Depression A Randomized Sham-Controlled Trial" in Journal of ECT, 30, no. 4 (2014):325-331,
https://doi.org/10.1097/YCT.0000000000000099 . .