TY  - JOUR
AU  - Bokan, Goran
AU  - Glamočanin, Tanja
AU  - Mavija, Zoran
AU  - Vidović, Bojana
AU  - Stojanović, Ana
AU  - Björnsson, Einar S.
AU  - Vučić, Vesna
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1341
AB  - Herb-induced liver injury (HILI) caused by herbal supplements, natural products, and products used in traditional medicine are important for differential diagnoses in patients with acute liver injury without an obvious etiology. The root of Withania somnifera (L.) Dunal, commonly known as ashwagandha, has been used in Ayurvedic medicine for thousands of years to promote health and longevity. Due to various biological activities, ashwagandha and its extracts became widespread as herbal supplements on the global market. Although it is generally considered safe, there are several reported cases of ashwagandha-related liver injury, and one case ended with liver transplantation. In this paper, we review all reported cases so far. Additionally, we describe two new cases of ashwagandha hepatotoxicity. In the first case, a 36-year-old man used ashwagandha capsules (450 mg, three times daily) for 6 months before he developed nausea, pruritus, and dark-colored urine. In the second case, a 30-year-old woman developed pruritus after 45 days of using ashwagandha capsules (450 mg). In both cases, serum bilirubin and liver enzymes (aspartate transaminase (AST), alanine transaminase (ALT), and alkaline phosphatase (ALP) were increased. The liver injury pattern was hepatocellular (R-value 11.1) and mixed (R-value 2.6), respectively. The updated Roussel Uclaf Causality Assessment Method (RUCAM) (both cases with a score of seven) indicated a “probable” relationship with ashwagandha. Clinical and liver function improvements were observed after the discontinuation of ashwagandha supplement use. By increasing the data related to ashwagandha-induced liver injury, these reports support that consuming ashwagandha supplements is not without its safety concerns.
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Pharmaceuticals
T2  - Pharmaceuticals
T1  - Herb-Induced Liver Injury by Ayurvedic Ashwagandha as Assessed for Causality by the Updated RUCAM: An Emerging Cause
IS  - 8
VL  - 16
DO  - 10.3390/ph16081129
ER  - 

@article{
author = "Bokan, Goran and Glamočanin, Tanja and Mavija, Zoran and Vidović, Bojana and Stojanović, Ana and Björnsson, Einar S. and Vučić, Vesna",
year = "2023",
abstract = "Herb-induced liver injury (HILI) caused by herbal supplements, natural products, and products used in traditional medicine are important for differential diagnoses in patients with acute liver injury without an obvious etiology. The root of Withania somnifera (L.) Dunal, commonly known as ashwagandha, has been used in Ayurvedic medicine for thousands of years to promote health and longevity. Due to various biological activities, ashwagandha and its extracts became widespread as herbal supplements on the global market. Although it is generally considered safe, there are several reported cases of ashwagandha-related liver injury, and one case ended with liver transplantation. In this paper, we review all reported cases so far. Additionally, we describe two new cases of ashwagandha hepatotoxicity. In the first case, a 36-year-old man used ashwagandha capsules (450 mg, three times daily) for 6 months before he developed nausea, pruritus, and dark-colored urine. In the second case, a 30-year-old woman developed pruritus after 45 days of using ashwagandha capsules (450 mg). In both cases, serum bilirubin and liver enzymes (aspartate transaminase (AST), alanine transaminase (ALT), and alkaline phosphatase (ALP) were increased. The liver injury pattern was hepatocellular (R-value 11.1) and mixed (R-value 2.6), respectively. The updated Roussel Uclaf Causality Assessment Method (RUCAM) (both cases with a score of seven) indicated a “probable” relationship with ashwagandha. Clinical and liver function improvements were observed after the discontinuation of ashwagandha supplement use. By increasing the data related to ashwagandha-induced liver injury, these reports support that consuming ashwagandha supplements is not without its safety concerns.",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Pharmaceuticals, Pharmaceuticals",
title = "Herb-Induced Liver Injury by Ayurvedic Ashwagandha as Assessed for Causality by the Updated RUCAM: An Emerging Cause",
number = "8",
volume = "16",
doi = "10.3390/ph16081129"
}

Bokan, G., Glamočanin, T., Mavija, Z., Vidović, B., Stojanović, A., Björnsson, E. S.,& Vučić, V.. (2023). Herb-Induced Liver Injury by Ayurvedic Ashwagandha as Assessed for Causality by the Updated RUCAM: An Emerging Cause. in Pharmaceuticals
Multidisciplinary Digital Publishing Institute (MDPI)., 16(8).
https://doi.org/10.3390/ph16081129

Bokan G, Glamočanin T, Mavija Z, Vidović B, Stojanović A, Björnsson ES, Vučić V. Herb-Induced Liver Injury by Ayurvedic Ashwagandha as Assessed for Causality by the Updated RUCAM: An Emerging Cause. in Pharmaceuticals. 2023;16(8).
doi:10.3390/ph16081129 .

Bokan, Goran, Glamočanin, Tanja, Mavija, Zoran, Vidović, Bojana, Stojanović, Ana, Björnsson, Einar S., Vučić, Vesna, "Herb-Induced Liver Injury by Ayurvedic Ashwagandha as Assessed for Causality by the Updated RUCAM: An Emerging Cause" in Pharmaceuticals, 16, no. 8 (2023),
https://doi.org/10.3390/ph16081129 . .

TY  - JOUR
AU  - Arsić, Aleksandra
AU  - Stojanović, Ana
AU  - Mikić, Milena
PY  - 2019
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/916
AB  - Oleic acid has many beneficial effects on human health. One of the main dietary sources of oleic acid is olive oil. Non-Mediterranean European countries, including Serbia, have low habitual olive oil consumption, but other vegetable oils also contain different amounts of oleic acid. In infants and young children m ilk is the most important source of fatty acids, including oleic acid. Furthermore, fatty acid composition of plasma phospholipids reflects dietary intake and fatty acid metabolism. In patients with serious chronic diseases fatty acid status is altered independently on the intake. Here we reviewed status of oleic acid in healthy persons as well as in patients with different chronic diseases in Serbia.
AB  - Oleinska kiselina ima ima višestrukepozitivne efekte na život i zdravlje ljudi. Jedan od glavnih izvora oleinske kiseline je maslinovo ulje. Evropske zemlje, koje nepripadaju mediteranskoj regiji, među kojima je i Srbija, retko koriste maslinovo ulje u ishrani, ali i druga biljna ulja sadrže oleinsku kiselinu u različitom procentu. Kod odojčadi i dece mlađeg uzrasta, mleko je najvažniji izvor masnih kiselina, uključujući i oleinsku. Dijetetski unos masnih kiselina i njihov metabolizam u telu, odražava masnokiselinski sastav ufosfolipidima plazme. Kod pacijenata sa teškim hroničnim oboljenjima, masnokiselinski sastav je promenjen nezavisno od unosa. U ovom radu je prikazan status oleinske kiseline kod zdravih osoba, kao i kod pacijenata sa različitim hroničnim oboljenjima u Srbiji.
PB  - Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac
T2  - Serbian Journal of Experimental & Clinical Research
T1  - Oleic acid: Health benefits and status in plasma phospholipids in the Serbian population
T1  - Oleinska kiselina - uticaj na zdravlje i status u fosfolipidima plazme u srpskoj populaciji
EP  - 8
IS  - 2
SP  - 3
VL  - 20
DO  - 10.1515/sjecr-2017-0077
ER  - 

@article{
author = "Arsić, Aleksandra and Stojanović, Ana and Mikić, Milena",
year = "2019",
abstract = "Oleic acid has many beneficial effects on human health. One of the main dietary sources of oleic acid is olive oil. Non-Mediterranean European countries, including Serbia, have low habitual olive oil consumption, but other vegetable oils also contain different amounts of oleic acid. In infants and young children m ilk is the most important source of fatty acids, including oleic acid. Furthermore, fatty acid composition of plasma phospholipids reflects dietary intake and fatty acid metabolism. In patients with serious chronic diseases fatty acid status is altered independently on the intake. Here we reviewed status of oleic acid in healthy persons as well as in patients with different chronic diseases in Serbia., Oleinska kiselina ima ima višestrukepozitivne efekte na život i zdravlje ljudi. Jedan od glavnih izvora oleinske kiseline je maslinovo ulje. Evropske zemlje, koje nepripadaju mediteranskoj regiji, među kojima je i Srbija, retko koriste maslinovo ulje u ishrani, ali i druga biljna ulja sadrže oleinsku kiselinu u različitom procentu. Kod odojčadi i dece mlađeg uzrasta, mleko je najvažniji izvor masnih kiselina, uključujući i oleinsku. Dijetetski unos masnih kiselina i njihov metabolizam u telu, odražava masnokiselinski sastav ufosfolipidima plazme. Kod pacijenata sa teškim hroničnim oboljenjima, masnokiselinski sastav je promenjen nezavisno od unosa. U ovom radu je prikazan status oleinske kiseline kod zdravih osoba, kao i kod pacijenata sa različitim hroničnim oboljenjima u Srbiji.",
publisher = "Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac",
journal = "Serbian Journal of Experimental & Clinical Research",
title = "Oleic acid: Health benefits and status in plasma phospholipids in the Serbian population, Oleinska kiselina - uticaj na zdravlje i status u fosfolipidima plazme u srpskoj populaciji",
pages = "8-3",
number = "2",
volume = "20",
doi = "10.1515/sjecr-2017-0077"
}

Arsić, A., Stojanović, A.,& Mikić, M.. (2019). Oleic acid: Health benefits and status in plasma phospholipids in the Serbian population. in Serbian Journal of Experimental & Clinical Research
Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac., 20(2), 3-8.
https://doi.org/10.1515/sjecr-2017-0077

Arsić A, Stojanović A, Mikić M. Oleic acid: Health benefits and status in plasma phospholipids in the Serbian population. in Serbian Journal of Experimental & Clinical Research. 2019;20(2):3-8.
doi:10.1515/sjecr-2017-0077 .

Arsić, Aleksandra, Stojanović, Ana, Mikić, Milena, "Oleic acid: Health benefits and status in plasma phospholipids in the Serbian population" in Serbian Journal of Experimental & Clinical Research, 20, no. 2 (2019):3-8,
https://doi.org/10.1515/sjecr-2017-0077 . .

TY  - JOUR
AU  - Stojanović, Ana
AU  - Zeković, Milica
AU  - Rašić-Milutinović, Zorica
AU  - Ristić-Medić, Danijela
AU  - Pokimica, Biljana
AU  - Debeljak-Martačić, Jasmina
AU  - Vučić, Vesna M.
PY  - 2018
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/899
AB  - Introduction/Objective Although smoking is the main risk factor for lung cancer (LC), studies have shown that diet could also play an important role. The objective of this study was to analyze dietary intake of newly diagnosed LC patients and to compare with sex- and age-matched healthy controls. Methods Sixty-nine non-treated LC patients (50 male, 19 female, aged 46-80 years), and 70 healthy controls (50 male, 20 female, aged 47-76 years) filled out a validated food frequency questionnaire in the presence of a trained nutritionist. Nutrient intake was calculated using the Serbian Food Composition Database. Results Similar energy intake was reported by both groups. However, the controls had significantly higher intake of total fats, saturated, monounsaturated, and n-3 polyunsaturated fatty acids (PUFAs) and lower intake of carbohydrates and n-6 PUFAs. Patients with LC reported markedly lower intake of milk and dairy products, eggs, seafood, vegetables, and fruits, and higher intake of grains and grain products. Conclusion Patients with LC had significantly different dietary intake of most nutrients compared to healthy participants, suggesting that changes in dietary patterns could contribute to prevention of LC development.
AB  - Uvod/Cilj Iako je pušenje vodeći faktor rizika za rak pluća (RP), studije pokazuju da i način ishrane igra važnu ulogu. Cilj ove studije je da se analiza ishrana kod bolesnika sa novodijagnostikovanim RP i da se uporedi sa zdravom populacijom istog pola i godina starosti. Metode Šezdeset devet bolesnika sa novootkrivenim RP (50 muškaraca, 19 žena, starosti 46-80 godina) i 70 zdravih ispitanika (50 muškaraca, 20 žena, starosti 47-76 godina) popunilo je u prisustvu lekara upitnik o učestalosti kon- zumiranja namirnica. Nutritivni unos je računat pomoću Srpske baze podataka o sastavu namirnica. Rezultati Obe grupe su imale sličan unos energije, ali je u kontrolnoj grupi zabeležen veći unos masti, zasićenih, mononezasićenih i n-3 polinezasićenih masnih kiselina (PNMK), a niži unos ugljenih hidrata i n-6 PNMK. Grupa bolesnika je imala značajno niži unos mleka i mlečnih proizvoda, jaja, morskih plodova, voća i povrća, a veći unos žitarica i proizvoda od brašna. Zaključak Bolesnici sa RP imali su značajno drugačiji način ishrane od zdravih ispitanika, što sugeriše da promene u načinu ishrane mogu da doprinesu prevenciji nastanka kancera pluća.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Dietary intake in newly diagnosed lung cancer patients
T1  - Ishrana bolesnika sa novodijagnostikovanim rakom pluća
EP  - 30
IS  - 1-2
SP  - 26
VL  - 146
DO  - 10.2298/SARH170301115S
ER  - 

@article{
author = "Stojanović, Ana and Zeković, Milica and Rašić-Milutinović, Zorica and Ristić-Medić, Danijela and Pokimica, Biljana and Debeljak-Martačić, Jasmina and Vučić, Vesna M.",
year = "2018",
abstract = "Introduction/Objective Although smoking is the main risk factor for lung cancer (LC), studies have shown that diet could also play an important role. The objective of this study was to analyze dietary intake of newly diagnosed LC patients and to compare with sex- and age-matched healthy controls. Methods Sixty-nine non-treated LC patients (50 male, 19 female, aged 46-80 years), and 70 healthy controls (50 male, 20 female, aged 47-76 years) filled out a validated food frequency questionnaire in the presence of a trained nutritionist. Nutrient intake was calculated using the Serbian Food Composition Database. Results Similar energy intake was reported by both groups. However, the controls had significantly higher intake of total fats, saturated, monounsaturated, and n-3 polyunsaturated fatty acids (PUFAs) and lower intake of carbohydrates and n-6 PUFAs. Patients with LC reported markedly lower intake of milk and dairy products, eggs, seafood, vegetables, and fruits, and higher intake of grains and grain products. Conclusion Patients with LC had significantly different dietary intake of most nutrients compared to healthy participants, suggesting that changes in dietary patterns could contribute to prevention of LC development., Uvod/Cilj Iako je pušenje vodeći faktor rizika za rak pluća (RP), studije pokazuju da i način ishrane igra važnu ulogu. Cilj ove studije je da se analiza ishrana kod bolesnika sa novodijagnostikovanim RP i da se uporedi sa zdravom populacijom istog pola i godina starosti. Metode Šezdeset devet bolesnika sa novootkrivenim RP (50 muškaraca, 19 žena, starosti 46-80 godina) i 70 zdravih ispitanika (50 muškaraca, 20 žena, starosti 47-76 godina) popunilo je u prisustvu lekara upitnik o učestalosti kon- zumiranja namirnica. Nutritivni unos je računat pomoću Srpske baze podataka o sastavu namirnica. Rezultati Obe grupe su imale sličan unos energije, ali je u kontrolnoj grupi zabeležen veći unos masti, zasićenih, mononezasićenih i n-3 polinezasićenih masnih kiselina (PNMK), a niži unos ugljenih hidrata i n-6 PNMK. Grupa bolesnika je imala značajno niži unos mleka i mlečnih proizvoda, jaja, morskih plodova, voća i povrća, a veći unos žitarica i proizvoda od brašna. Zaključak Bolesnici sa RP imali su značajno drugačiji način ishrane od zdravih ispitanika, što sugeriše da promene u načinu ishrane mogu da doprinesu prevenciji nastanka kancera pluća.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Dietary intake in newly diagnosed lung cancer patients, Ishrana bolesnika sa novodijagnostikovanim rakom pluća",
pages = "30-26",
number = "1-2",
volume = "146",
doi = "10.2298/SARH170301115S"
}

Stojanović, A., Zeković, M., Rašić-Milutinović, Z., Ristić-Medić, D., Pokimica, B., Debeljak-Martačić, J.,& Vučić, V. M.. (2018). Dietary intake in newly diagnosed lung cancer patients. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 146(1-2), 26-30.
https://doi.org/10.2298/SARH170301115S

Stojanović A, Zeković M, Rašić-Milutinović Z, Ristić-Medić D, Pokimica B, Debeljak-Martačić J, Vučić VM. Dietary intake in newly diagnosed lung cancer patients. in Srpski arhiv za celokupno lekarstvo. 2018;146(1-2):26-30.
doi:10.2298/SARH170301115S .

Stojanović, Ana, Zeković, Milica, Rašić-Milutinović, Zorica, Ristić-Medić, Danijela, Pokimica, Biljana, Debeljak-Martačić, Jasmina, Vučić, Vesna M., "Dietary intake in newly diagnosed lung cancer patients" in Srpski arhiv za celokupno lekarstvo, 146, no. 1-2 (2018):26-30,
https://doi.org/10.2298/SARH170301115S . .