TY  - JOUR
AU  - Veselinović, Aleksandra
AU  - Petrović, Snježana
AU  - Žikić, Vladica
AU  - Subotić, Miško
AU  - Jakovljević, Vladimir
AU  - Jeremić, Nevena
AU  - Vučić, Vesna M.
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1161
AB  - Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder characterized by persistent deficits in social communication and social interaction across multiple contexts and restricted, repetitive patterns of behavior, interests and activities. The maternal status of polyunsaturated fatty acids (PUFA) regulates microglial activity and neuroinflammatory pathways during a child’s brain development. In children with ASD, the metabolism of PUFA is thought to be deficient or abnormal, leading to increased production of proinflammatory cytokines, increased oxidative stress and an imbalance in the formation and action of neurotransmitters. In addition, nutritional deficits in omega-3 PUFA may affect gut microbiota and contribute to ASD by the gut–brain axis. The aim of this study was to review the possible role of neuroinflammation in ASD development and the effect of omega-3 PUFA supplementation in children with ASD. Due to a wide heterogeneity across RCTs, no definitive conclusion about omega-3 PUFA effects in ASD can be drawn. Supplementation with PUFA could be considered as one of the aspects in regulating the biological status of the organism and could provide added value to standard medical and psychological interventions for reducing behavioral deficits.
PB  - MDPI
T2  - Medicina
T1  - Neuroinflammation in Autism and Supplementation Based on Omega-3 Polyunsaturated Fatty Acids: A Narrative Review
IS  - 9
SP  - 893
VL  - 57
DO  - 10.3390/medicina57090893
ER  - 

@article{
author = "Veselinović, Aleksandra and Petrović, Snježana and Žikić, Vladica and Subotić, Miško and Jakovljević, Vladimir and Jeremić, Nevena and Vučić, Vesna M.",
year = "2021",
abstract = "Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder characterized by persistent deficits in social communication and social interaction across multiple contexts and restricted, repetitive patterns of behavior, interests and activities. The maternal status of polyunsaturated fatty acids (PUFA) regulates microglial activity and neuroinflammatory pathways during a child’s brain development. In children with ASD, the metabolism of PUFA is thought to be deficient or abnormal, leading to increased production of proinflammatory cytokines, increased oxidative stress and an imbalance in the formation and action of neurotransmitters. In addition, nutritional deficits in omega-3 PUFA may affect gut microbiota and contribute to ASD by the gut–brain axis. The aim of this study was to review the possible role of neuroinflammation in ASD development and the effect of omega-3 PUFA supplementation in children with ASD. Due to a wide heterogeneity across RCTs, no definitive conclusion about omega-3 PUFA effects in ASD can be drawn. Supplementation with PUFA could be considered as one of the aspects in regulating the biological status of the organism and could provide added value to standard medical and psychological interventions for reducing behavioral deficits.",
publisher = "MDPI",
journal = "Medicina",
title = "Neuroinflammation in Autism and Supplementation Based on Omega-3 Polyunsaturated Fatty Acids: A Narrative Review",
number = "9",
pages = "893",
volume = "57",
doi = "10.3390/medicina57090893"
}

Veselinović, A., Petrović, S., Žikić, V., Subotić, M., Jakovljević, V., Jeremić, N.,& Vučić, V. M.. (2021). Neuroinflammation in Autism and Supplementation Based on Omega-3 Polyunsaturated Fatty Acids: A Narrative Review. in Medicina
MDPI., 57(9), 893.
https://doi.org/10.3390/medicina57090893

Veselinović A, Petrović S, Žikić V, Subotić M, Jakovljević V, Jeremić N, Vučić VM. Neuroinflammation in Autism and Supplementation Based on Omega-3 Polyunsaturated Fatty Acids: A Narrative Review. in Medicina. 2021;57(9):893.
doi:10.3390/medicina57090893 .

Veselinović, Aleksandra, Petrović, Snježana, Žikić, Vladica, Subotić, Miško, Jakovljević, Vladimir, Jeremić, Nevena, Vučić, Vesna M., "Neuroinflammation in Autism and Supplementation Based on Omega-3 Polyunsaturated Fatty Acids: A Narrative Review" in Medicina, 57, no. 9 (2021):893,
https://doi.org/10.3390/medicina57090893 . .