TY  - JOUR
AU  - Takić, Marija
AU  - Ranković, Slavica
AU  - Girek, Zdenka
AU  - Pavlović, Suzana
AU  - Jovanović, Petar
AU  - Jovanović, Vesna
AU  - Šarac, Ivana
PY  - 2024
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1483
AB  - The plant-derived α-linolenic acid (ALA) is an essential n-3 acid highly susceptible to oxidation, present in oils of flaxseeds, walnuts, canola, perilla, soy, and chia. After ingestion, it can be incorporated in to body lipid pools (particularly triglycerides and phospholipid membranes), and then endogenously metabolized through desaturation, elongation, and peroxisome oxidation to eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), with a very limited efficiency (particularly for DHA), beta-oxidized as an energy source, or directly metabolized to C18-oxilipins. At this moment, data in the literature about the effects of ALA supplementation on metabolic syndrome (MetS) in humans are inconsistent, indicating no effects or some positive effects on all MetS components (abdominal obesity, dyslipidemia, impaired insulin sensitivity and glucoregulation, blood pressure, and liver steatosis). The major effects of ALA on MetS seem to be through its conversion to more potent EPA and DHA, the impact on the n-3/n-6 ratio, and the consecutive effects on the formation of oxylipins and endocannabinoids, inflammation, insulin sensitivity, and insulin secretion, as well as adipocyte and hepatocytes function. It is important to distinguish the direct effects of ALA from the effects of EPA and DHA metabolites. This review summarizes the most recent findings on this topic and discusses the possible mechanisms.
PB  - Basel : MDPI (Multidisciplinary Digital Publishing Institute)
T2  - International Journal of Molecular Sciences
T2  - International Journal of Molecular Sciences
T1  - Current Insights into the Effects of Dietary α-Linolenic Acid Focusing on Alterations of Polyunsaturated Fatty Acid Profiles in Metabolic Syndrome
IS  - 9
SP  - 4909
VL  - 25
DO  - 10.3390/ijms25094909
ER  - 

@article{
author = "Takić, Marija and Ranković, Slavica and Girek, Zdenka and Pavlović, Suzana and Jovanović, Petar and Jovanović, Vesna and Šarac, Ivana",
year = "2024",
abstract = "The plant-derived α-linolenic acid (ALA) is an essential n-3 acid highly susceptible to oxidation, present in oils of flaxseeds, walnuts, canola, perilla, soy, and chia. After ingestion, it can be incorporated in to body lipid pools (particularly triglycerides and phospholipid membranes), and then endogenously metabolized through desaturation, elongation, and peroxisome oxidation to eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), with a very limited efficiency (particularly for DHA), beta-oxidized as an energy source, or directly metabolized to C18-oxilipins. At this moment, data in the literature about the effects of ALA supplementation on metabolic syndrome (MetS) in humans are inconsistent, indicating no effects or some positive effects on all MetS components (abdominal obesity, dyslipidemia, impaired insulin sensitivity and glucoregulation, blood pressure, and liver steatosis). The major effects of ALA on MetS seem to be through its conversion to more potent EPA and DHA, the impact on the n-3/n-6 ratio, and the consecutive effects on the formation of oxylipins and endocannabinoids, inflammation, insulin sensitivity, and insulin secretion, as well as adipocyte and hepatocytes function. It is important to distinguish the direct effects of ALA from the effects of EPA and DHA metabolites. This review summarizes the most recent findings on this topic and discusses the possible mechanisms.",
publisher = "Basel : MDPI (Multidisciplinary Digital Publishing Institute)",
journal = "International Journal of Molecular Sciences, International Journal of Molecular Sciences",
title = "Current Insights into the Effects of Dietary α-Linolenic Acid Focusing on Alterations of Polyunsaturated Fatty Acid Profiles in Metabolic Syndrome",
number = "9",
pages = "4909",
volume = "25",
doi = "10.3390/ijms25094909"
}

Takić, M., Ranković, S., Girek, Z., Pavlović, S., Jovanović, P., Jovanović, V.,& Šarac, I.. (2024). Current Insights into the Effects of Dietary α-Linolenic Acid Focusing on Alterations of Polyunsaturated Fatty Acid Profiles in Metabolic Syndrome. in International Journal of Molecular Sciences
Basel : MDPI (Multidisciplinary Digital Publishing Institute)., 25(9), 4909.
https://doi.org/10.3390/ijms25094909

Takić M, Ranković S, Girek Z, Pavlović S, Jovanović P, Jovanović V, Šarac I. Current Insights into the Effects of Dietary α-Linolenic Acid Focusing on Alterations of Polyunsaturated Fatty Acid Profiles in Metabolic Syndrome. in International Journal of Molecular Sciences. 2024;25(9):4909.
doi:10.3390/ijms25094909 .

Takić, Marija, Ranković, Slavica, Girek, Zdenka, Pavlović, Suzana, Jovanović, Petar, Jovanović, Vesna, Šarac, Ivana, "Current Insights into the Effects of Dietary α-Linolenic Acid Focusing on Alterations of Polyunsaturated Fatty Acid Profiles in Metabolic Syndrome" in International Journal of Molecular Sciences, 25, no. 9 (2024):4909,
https://doi.org/10.3390/ijms25094909 . .

TY  - JOUR
AU  - Uzelac, Tamara
AU  - Smiljanić, Katarina
AU  - Takić, Marija
AU  - Šarac, Ivana
AU  - Oggiano, Gordana
AU  - Nikolić, Milan
AU  - Jovanović, Vesna
PY  - 2024
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1467
AB  - The binding of ubiquitous serum ligands (free fatty acids) to human serum albumin (HSA) or its glycation can affect thiol group reactivity, thus influencing its antioxidant activity. The effects of stearic acid (SA) and glucose binding on HSA structural changes and thiol group content and reactivity were monitored by fluoroscopy and the Ellman method during a 14-day incubation in molar ratios to HSA that mimic pathophysiological conditions. Upon incubation with 5 mM glucose, HSA glycation was the same as HSA without it, in three different HSA:SA molar ratios (HSA:SA-1:1-2-4). The protective effect of SA on the antioxidant property of HSA under different glucose regimes (5-10-20 mM) was significantly affected by molar ratios of HSA:SA. Thiol reactivity was fully restored with 5–20 mM glucose at a 1:1 HSA:SA ratio, while the highest thiol content recovery was in pathological glucose regimes at a 1:1 HSA:SA ratio. The SA affinity for HSA increased significantly (1.5- and 1.3-fold, p < 0.01) with 5 and 10 mM glucose compared to the control. These results deepen the knowledge about the possible regulation of the antioxidant role of HSA in diabetes and other pathophysiological conditions and enable the design of future HSA-drug studies which, in turn, is important for clinicians when designing information-based treatments.
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
T2  - International Journal of Molecular Sciences
T1  - The Thiol Group Reactivity and the Antioxidant Property of Human Serum Albumin Are Controlled by the Joint Action of Fatty Acids and Glucose Binding
IS  - 4
SP  - 2335
VL  - 25
DO  - 10.3390/ijms25042335
ER  - 

@article{
author = "Uzelac, Tamara and Smiljanić, Katarina and Takić, Marija and Šarac, Ivana and Oggiano, Gordana and Nikolić, Milan and Jovanović, Vesna",
year = "2024",
abstract = "The binding of ubiquitous serum ligands (free fatty acids) to human serum albumin (HSA) or its glycation can affect thiol group reactivity, thus influencing its antioxidant activity. The effects of stearic acid (SA) and glucose binding on HSA structural changes and thiol group content and reactivity were monitored by fluoroscopy and the Ellman method during a 14-day incubation in molar ratios to HSA that mimic pathophysiological conditions. Upon incubation with 5 mM glucose, HSA glycation was the same as HSA without it, in three different HSA:SA molar ratios (HSA:SA-1:1-2-4). The protective effect of SA on the antioxidant property of HSA under different glucose regimes (5-10-20 mM) was significantly affected by molar ratios of HSA:SA. Thiol reactivity was fully restored with 5–20 mM glucose at a 1:1 HSA:SA ratio, while the highest thiol content recovery was in pathological glucose regimes at a 1:1 HSA:SA ratio. The SA affinity for HSA increased significantly (1.5- and 1.3-fold, p < 0.01) with 5 and 10 mM glucose compared to the control. These results deepen the knowledge about the possible regulation of the antioxidant role of HSA in diabetes and other pathophysiological conditions and enable the design of future HSA-drug studies which, in turn, is important for clinicians when designing information-based treatments.",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "International Journal of Molecular Sciences",
title = "The Thiol Group Reactivity and the Antioxidant Property of Human Serum Albumin Are Controlled by the Joint Action of Fatty Acids and Glucose Binding",
number = "4",
pages = "2335",
volume = "25",
doi = "10.3390/ijms25042335"
}

Uzelac, T., Smiljanić, K., Takić, M., Šarac, I., Oggiano, G., Nikolić, M.,& Jovanović, V.. (2024). The Thiol Group Reactivity and the Antioxidant Property of Human Serum Albumin Are Controlled by the Joint Action of Fatty Acids and Glucose Binding. in International Journal of Molecular Sciences
Multidisciplinary Digital Publishing Institute (MDPI)., 25(4), 2335.
https://doi.org/10.3390/ijms25042335

Uzelac T, Smiljanić K, Takić M, Šarac I, Oggiano G, Nikolić M, Jovanović V. The Thiol Group Reactivity and the Antioxidant Property of Human Serum Albumin Are Controlled by the Joint Action of Fatty Acids and Glucose Binding. in International Journal of Molecular Sciences. 2024;25(4):2335.
doi:10.3390/ijms25042335 .

Uzelac, Tamara, Smiljanić, Katarina, Takić, Marija, Šarac, Ivana, Oggiano, Gordana, Nikolić, Milan, Jovanović, Vesna, "The Thiol Group Reactivity and the Antioxidant Property of Human Serum Albumin Are Controlled by the Joint Action of Fatty Acids and Glucose Binding" in International Journal of Molecular Sciences, 25, no. 4 (2024):2335,
https://doi.org/10.3390/ijms25042335 . .

TY  - CONF
AU  - Milešević, Jelena
AU  - Zeković, Milica
AU  - Šarac, Ivana
AU  - Knez, Marija
AU  - Takić, Marija
AU  - Debeljak Martačić, Jasmina
AU  - Gurinović, Mirjana
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1432
AB  - The Serbian National Food Consumption Survey on adults from 10 to 74 years old, including pregnant women and vegetarians, was conducted in compliance with the EFSA EU Menu project support and guidance from 2017 to 2022. Valid data were collected from a total of 3018 participants with 856 adolescents aged 10 to 17 years, 1155 adults aged 18 to 64, 581 elderly subjects aged 65 to 74 years, 145 pregnant women, and 281 persons following a vegetarian diet. Data collection was conducted using a national Survey Pack designed for the project, including the following: a general questionnaire, an age-appropriate Food Propensity Questionnaire, an International Physical Activity Questionnaire, and 24 h dietary recall. The advanced nutritional platform Diet Assess and Plan (DAP) was applied for data storage, processing, and the creation of the final dataset for transfer to EFSA. The Serbian food composition database was used and updated during the project as a resource of food information for all foods and recipes that were consumed by the study cohort. Regardless of age and
gender category, the majority (56%) of adults had normal weight according to the Body Mass Index,while 21% were overweight, and 15.5% were underweight. The average daily energy intake was 2178.72 kcal, while overall contributions of carbohydrates, protein, and fat to the total energy intake were 43.37%, 15.47%, and 41.16%, respectively. The proportions of macronutrient intake deviated from the dietary reference values, particularly for fat, which was often too high, where sunflower oil was the major source of fat in diets. Out of the 3018 participants, 98% had breakfast, 99% had lunch,
and 95% had dinner, while approx. 80% had snacks between main meals. The highest energy intake was recorded during lunch, 706.5 kcal (32% TE). The survey results provide valuable insight into the nutritional status and dietary habits of adults from 10 to 74 years old living in Serbia. The Serbian food consumption database serves as an evidence platform for decision-making processes in public health nutrition policies and strategies, diet monitoring, exposure risk assessments, and interventions targeting identified nutritional challenges in particular population groups. Harmonized data are part of the EFSA comprehensive food consumption database.
PB  - Basel, Switzerland: MDPI (Multidisciplinary Digital Publishing Institute)
C3  - Proceedings of The 14th European Nutrition Conference FENS 2023: “Food, Nutrition and Health:Translating Science into Practice”, 14 to 17 November 2023, Belgrade, Serbia
T1  - Nutritional and Anthropometric Status of Serbian Adults 10–74 Years Old: Results from European Food Safety Authority (EFSA) EU Menu Food Consumption Survey 2017–2021
IS  - 1
SP  - 15
VL  - 91
DO  - 10.3390/proceedings2023091015
ER  - 

@conference{
author = "Milešević, Jelena and Zeković, Milica and Šarac, Ivana and Knez, Marija and Takić, Marija and Debeljak Martačić, Jasmina and Gurinović, Mirjana",
year = "2023",
abstract = "The Serbian National Food Consumption Survey on adults from 10 to 74 years old, including pregnant women and vegetarians, was conducted in compliance with the EFSA EU Menu project support and guidance from 2017 to 2022. Valid data were collected from a total of 3018 participants with 856 adolescents aged 10 to 17 years, 1155 adults aged 18 to 64, 581 elderly subjects aged 65 to 74 years, 145 pregnant women, and 281 persons following a vegetarian diet. Data collection was conducted using a national Survey Pack designed for the project, including the following: a general questionnaire, an age-appropriate Food Propensity Questionnaire, an International Physical Activity Questionnaire, and 24 h dietary recall. The advanced nutritional platform Diet Assess and Plan (DAP) was applied for data storage, processing, and the creation of the final dataset for transfer to EFSA. The Serbian food composition database was used and updated during the project as a resource of food information for all foods and recipes that were consumed by the study cohort. Regardless of age and
gender category, the majority (56%) of adults had normal weight according to the Body Mass Index,while 21% were overweight, and 15.5% were underweight. The average daily energy intake was 2178.72 kcal, while overall contributions of carbohydrates, protein, and fat to the total energy intake were 43.37%, 15.47%, and 41.16%, respectively. The proportions of macronutrient intake deviated from the dietary reference values, particularly for fat, which was often too high, where sunflower oil was the major source of fat in diets. Out of the 3018 participants, 98% had breakfast, 99% had lunch,
and 95% had dinner, while approx. 80% had snacks between main meals. The highest energy intake was recorded during lunch, 706.5 kcal (32% TE). The survey results provide valuable insight into the nutritional status and dietary habits of adults from 10 to 74 years old living in Serbia. The Serbian food consumption database serves as an evidence platform for decision-making processes in public health nutrition policies and strategies, diet monitoring, exposure risk assessments, and interventions targeting identified nutritional challenges in particular population groups. Harmonized data are part of the EFSA comprehensive food consumption database.",
publisher = "Basel, Switzerland: MDPI (Multidisciplinary Digital Publishing Institute)",
journal = "Proceedings of The 14th European Nutrition Conference FENS 2023: “Food, Nutrition and Health:Translating Science into Practice”, 14 to 17 November 2023, Belgrade, Serbia",
title = "Nutritional and Anthropometric Status of Serbian Adults 10–74 Years Old: Results from European Food Safety Authority (EFSA) EU Menu Food Consumption Survey 2017–2021",
number = "1",
pages = "15",
volume = "91",
doi = "10.3390/proceedings2023091015"
}

Milešević, J., Zeković, M., Šarac, I., Knez, M., Takić, M., Debeljak Martačić, J.,& Gurinović, M.. (2023). Nutritional and Anthropometric Status of Serbian Adults 10–74 Years Old: Results from European Food Safety Authority (EFSA) EU Menu Food Consumption Survey 2017–2021. in Proceedings of The 14th European Nutrition Conference FENS 2023: “Food, Nutrition and Health:Translating Science into Practice”, 14 to 17 November 2023, Belgrade, Serbia
Basel, Switzerland: MDPI (Multidisciplinary Digital Publishing Institute)., 91(1), 15.
https://doi.org/10.3390/proceedings2023091015

Milešević J, Zeković M, Šarac I, Knez M, Takić M, Debeljak Martačić J, Gurinović M. Nutritional and Anthropometric Status of Serbian Adults 10–74 Years Old: Results from European Food Safety Authority (EFSA) EU Menu Food Consumption Survey 2017–2021. in Proceedings of The 14th European Nutrition Conference FENS 2023: “Food, Nutrition and Health:Translating Science into Practice”, 14 to 17 November 2023, Belgrade, Serbia. 2023;91(1):15.
doi:10.3390/proceedings2023091015 .

Milešević, Jelena, Zeković, Milica, Šarac, Ivana, Knez, Marija, Takić, Marija, Debeljak Martačić, Jasmina, Gurinović, Mirjana, "Nutritional and Anthropometric Status of Serbian Adults 10–74 Years Old: Results from European Food Safety Authority (EFSA) EU Menu Food Consumption Survey 2017–2021" in Proceedings of The 14th European Nutrition Conference FENS 2023: “Food, Nutrition and Health:Translating Science into Practice”, 14 to 17 November 2023, Belgrade, Serbia, 91, no. 1 (2023):15,
https://doi.org/10.3390/proceedings2023091015 . .

TY  - CONF
AU  - Gurinović, Mirjana
AU  - Milešević, Jelena
AU  - Zeković, Milica
AU  - Knez, Marija
AU  - Takić, Marija
AU  - Šarac, Ivana
AU  - Kadvan, Agneš
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1441
AB  - Harmonized and standardized collection, processing, and analysis of individual dietary data is essential for nutrition assessment and informed policy decision making. To underpin the harmonization of food consumption data collection methodologies and the development of a common, comprehensive European food consumption database, the European Food Safety Authority (EFSA) supported 36 child and/or adult dietary surveys in 18 EU Member States and four Balkan preaccession countries through the EU Menu Project. Given the lack of relevant and harmonized research and data on food and nutrition in the Balkan region, CENM-IMR and CAPNUTRA scientists focused their activities on capacity building in nutrition research, particularly on the creation of a contemporary, harmonized research infrastructure (RI) that meets European standards. The EFSA EU Menu methodology has been implemented in the Balkans through the adaptation and use of an innovative, comprehensive tool for the standardized collection of food consumption and dietary intake assessment data, the Diet Assess and Plan (DAP). DAP has the essential features of an RI needed to strengthen public health surveillance, monitoring, evaluation, and nutrition research; this is a unique example of a standardized and harmonized tool for assessing dietary intake, i.e., collecting data on food and nutrition in the Balkan region and beyond. It is a concurrent tool for large-scale nutritional epidemiological studies and represents one of the new technologies for dietary intake assessment. National dietary surveys were conducted from 2017 to 2023 among adults aged 10 to 74 years (in Bosnia and Herzegovina, Montenegro, and Serbia) and children aged three months to nine years (in Montenegro, North Macedonia, and Serbia). The collected data on food consumption are internationally comparable with other European countries under the EU Menu Program. The data collected will be used for dietary and exposure risk assessment, establishment of national nutrient reference values, as a basis for the development of food-based dietary guidelines, a tool to provide evidence and infrastructure for public health nutrition policy decisions, and for tailored pathways to transform the food system in the Balkans towards a more nutrition-sensitive and sustainable system.
PB  - Basel, Switzerland: MDPI (Multidisciplinary Digital Publishing Institute)
C3  - Proceedings of The 14th European Nutrition Conference FENS 2023: “Food, Nutrition and Health:Translating Science into Practice”, 14 to 17 November 2023, Belgrade, Serbia
T1  - Capacity Development and Harmonization of Food Consumption Data Collection in EFSA EU Menu National Dietary Surveys in Balkan Region-Building: The Evidence Base for Diet Monitoring and Food Systems Transformation
IS  - 1
SP  - 24
VL  - 91
DO  - 10.3390/proceedings2023091024
ER  - 

@conference{
author = "Gurinović, Mirjana and Milešević, Jelena and Zeković, Milica and Knez, Marija and Takić, Marija and Šarac, Ivana and Kadvan, Agneš",
year = "2023",
abstract = "Harmonized and standardized collection, processing, and analysis of individual dietary data is essential for nutrition assessment and informed policy decision making. To underpin the harmonization of food consumption data collection methodologies and the development of a common, comprehensive European food consumption database, the European Food Safety Authority (EFSA) supported 36 child and/or adult dietary surveys in 18 EU Member States and four Balkan preaccession countries through the EU Menu Project. Given the lack of relevant and harmonized research and data on food and nutrition in the Balkan region, CENM-IMR and CAPNUTRA scientists focused their activities on capacity building in nutrition research, particularly on the creation of a contemporary, harmonized research infrastructure (RI) that meets European standards. The EFSA EU Menu methodology has been implemented in the Balkans through the adaptation and use of an innovative, comprehensive tool for the standardized collection of food consumption and dietary intake assessment data, the Diet Assess and Plan (DAP). DAP has the essential features of an RI needed to strengthen public health surveillance, monitoring, evaluation, and nutrition research; this is a unique example of a standardized and harmonized tool for assessing dietary intake, i.e., collecting data on food and nutrition in the Balkan region and beyond. It is a concurrent tool for large-scale nutritional epidemiological studies and represents one of the new technologies for dietary intake assessment. National dietary surveys were conducted from 2017 to 2023 among adults aged 10 to 74 years (in Bosnia and Herzegovina, Montenegro, and Serbia) and children aged three months to nine years (in Montenegro, North Macedonia, and Serbia). The collected data on food consumption are internationally comparable with other European countries under the EU Menu Program. The data collected will be used for dietary and exposure risk assessment, establishment of national nutrient reference values, as a basis for the development of food-based dietary guidelines, a tool to provide evidence and infrastructure for public health nutrition policy decisions, and for tailored pathways to transform the food system in the Balkans towards a more nutrition-sensitive and sustainable system.",
publisher = "Basel, Switzerland: MDPI (Multidisciplinary Digital Publishing Institute)",
journal = "Proceedings of The 14th European Nutrition Conference FENS 2023: “Food, Nutrition and Health:Translating Science into Practice”, 14 to 17 November 2023, Belgrade, Serbia",
title = "Capacity Development and Harmonization of Food Consumption Data Collection in EFSA EU Menu National Dietary Surveys in Balkan Region-Building: The Evidence Base for Diet Monitoring and Food Systems Transformation",
number = "1",
pages = "24",
volume = "91",
doi = "10.3390/proceedings2023091024"
}

Gurinović, M., Milešević, J., Zeković, M., Knez, M., Takić, M., Šarac, I.,& Kadvan, A.. (2023). Capacity Development and Harmonization of Food Consumption Data Collection in EFSA EU Menu National Dietary Surveys in Balkan Region-Building: The Evidence Base for Diet Monitoring and Food Systems Transformation. in Proceedings of The 14th European Nutrition Conference FENS 2023: “Food, Nutrition and Health:Translating Science into Practice”, 14 to 17 November 2023, Belgrade, Serbia
Basel, Switzerland: MDPI (Multidisciplinary Digital Publishing Institute)., 91(1), 24.
https://doi.org/10.3390/proceedings2023091024

Gurinović M, Milešević J, Zeković M, Knez M, Takić M, Šarac I, Kadvan A. Capacity Development and Harmonization of Food Consumption Data Collection in EFSA EU Menu National Dietary Surveys in Balkan Region-Building: The Evidence Base for Diet Monitoring and Food Systems Transformation. in Proceedings of The 14th European Nutrition Conference FENS 2023: “Food, Nutrition and Health:Translating Science into Practice”, 14 to 17 November 2023, Belgrade, Serbia. 2023;91(1):24.
doi:10.3390/proceedings2023091024 .

Gurinović, Mirjana, Milešević, Jelena, Zeković, Milica, Knez, Marija, Takić, Marija, Šarac, Ivana, Kadvan, Agneš, "Capacity Development and Harmonization of Food Consumption Data Collection in EFSA EU Menu National Dietary Surveys in Balkan Region-Building: The Evidence Base for Diet Monitoring and Food Systems Transformation" in Proceedings of The 14th European Nutrition Conference FENS 2023: “Food, Nutrition and Health:Translating Science into Practice”, 14 to 17 November 2023, Belgrade, Serbia, 91, no. 1 (2023):24,
https://doi.org/10.3390/proceedings2023091024 . .

TY  - JOUR
AU  - Šarac, Ivana
AU  - Debeljak-Martačić, Jasmina
AU  - Takić, Marija
AU  - Stevanović, Vuk
AU  - Milešević, Jelena
AU  - Zeković, Milica
AU  - Popović, Tamara B.
AU  - Jovanović, Jovica
AU  - Kardum Vidović, Nevena
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1345
AB  - Introduction: Fatty acids (FAs) composition and desaturase activities can be altered in different metabolic conditions, but the adiposity-independent associations with clinical and biochemical indicators of cardiometabolic risk are still unclear. This study aimed to analyze the associations of FAs composition and estimated desaturase activities with anthropometric, clinical, and biochemical cardiometabolic risk indicators in non-diabetic Serbian women, and to investigate if these associations were independent of the level of adiposity and other confounders.

Methods: In 76 non-diabetic, otherwise healthy Serbian women, aged 24-68 years, with or without metabolic syndrome or obesity (BMI=23.6±5.6 kg/m2), FA composition in erythrocyte phospholipids was measured by gas-liquid chromatography. Desaturase activities were estimated from product/precursor FAs ratios (D9D:16:1n-7/16:0; D6D:20:3n-6/18:2n-6; D5D:20:4n-6/20:3n-6). Correlations were made with anthropometric, biochemical (serum glucose, triacylglycerols, LDL-C, HDL-C, ALT, AST, and their ratios) and clinical (blood pressure) indicators of cardiometabolic risk. Linear regression models were performed to test the independence of these associations.

Results: Estimated desaturase activities and certain FAs were associated with anthropometric, clinical and biochemical indicators of cardiometabolic risk: D9D, D6D, 16:1n-7 and 20:3n-6 were directly associated, while D5D and 18:0 were inversely associated. However, the associations with clinical and biochemical indicators were not independent of the associations with the level of adiposity, since they were lost after controlling for anthropometric indices. After controlling for multiple confounders (age, postmenopausal status, education, smoking, physical activity, dietary macronutrient intakes, use of supplements, alcohol consumption), the level of adiposity was the most significant predictor of desaturase activities and aforementioned FAs levels, and mediated their association with biochemical/clinical indicators. Vice versa, desaturase activities predicted the level of adiposity, but not other components of cardiometabolic risk (if the level of adiposity was accounted). While the associations of anthropometric indices with 16:1n-7, 20:3n-6, 18:0 and D9D and D6D activities were linear, the associations with D5D activity were the inverse U-shaped. The only adiposity-independent association of FAs profiles with the indicators of cardiometabolic risk was a positive association of 20:5n-3 with ALT/AST ratio, which requires further exploration.

Discussion: Additional studies are needed to explore the mechanisms of the observed associations.
PB  - Frontiers Media S.A.
T2  - Frontiers in Nutrition
T1  - Associations of fatty acids composition and estimated desaturase activities in erythrocyte phospholipids with biochemical and clinical indicators of cardiometabolic risk in non-diabetic Serbian women: the role of level of adiposity
VL  - 10
DO  - 10.3389/fnut.2023.1065578
UR  - https://hdl.handle.net/21.15107/rcub_rimi_1345
ER  - 

@article{
author = "Šarac, Ivana and Debeljak-Martačić, Jasmina and Takić, Marija and Stevanović, Vuk and Milešević, Jelena and Zeković, Milica and Popović, Tamara B. and Jovanović, Jovica and Kardum Vidović, Nevena",
year = "2023",
abstract = "Introduction: Fatty acids (FAs) composition and desaturase activities can be altered in different metabolic conditions, but the adiposity-independent associations with clinical and biochemical indicators of cardiometabolic risk are still unclear. This study aimed to analyze the associations of FAs composition and estimated desaturase activities with anthropometric, clinical, and biochemical cardiometabolic risk indicators in non-diabetic Serbian women, and to investigate if these associations were independent of the level of adiposity and other confounders.

Methods: In 76 non-diabetic, otherwise healthy Serbian women, aged 24-68 years, with or without metabolic syndrome or obesity (BMI=23.6±5.6 kg/m2), FA composition in erythrocyte phospholipids was measured by gas-liquid chromatography. Desaturase activities were estimated from product/precursor FAs ratios (D9D:16:1n-7/16:0; D6D:20:3n-6/18:2n-6; D5D:20:4n-6/20:3n-6). Correlations were made with anthropometric, biochemical (serum glucose, triacylglycerols, LDL-C, HDL-C, ALT, AST, and their ratios) and clinical (blood pressure) indicators of cardiometabolic risk. Linear regression models were performed to test the independence of these associations.

Results: Estimated desaturase activities and certain FAs were associated with anthropometric, clinical and biochemical indicators of cardiometabolic risk: D9D, D6D, 16:1n-7 and 20:3n-6 were directly associated, while D5D and 18:0 were inversely associated. However, the associations with clinical and biochemical indicators were not independent of the associations with the level of adiposity, since they were lost after controlling for anthropometric indices. After controlling for multiple confounders (age, postmenopausal status, education, smoking, physical activity, dietary macronutrient intakes, use of supplements, alcohol consumption), the level of adiposity was the most significant predictor of desaturase activities and aforementioned FAs levels, and mediated their association with biochemical/clinical indicators. Vice versa, desaturase activities predicted the level of adiposity, but not other components of cardiometabolic risk (if the level of adiposity was accounted). While the associations of anthropometric indices with 16:1n-7, 20:3n-6, 18:0 and D9D and D6D activities were linear, the associations with D5D activity were the inverse U-shaped. The only adiposity-independent association of FAs profiles with the indicators of cardiometabolic risk was a positive association of 20:5n-3 with ALT/AST ratio, which requires further exploration.

Discussion: Additional studies are needed to explore the mechanisms of the observed associations.",
publisher = "Frontiers Media S.A.",
journal = "Frontiers in Nutrition",
title = "Associations of fatty acids composition and estimated desaturase activities in erythrocyte phospholipids with biochemical and clinical indicators of cardiometabolic risk in non-diabetic Serbian women: the role of level of adiposity",
volume = "10",
doi = "10.3389/fnut.2023.1065578",
url = "https://hdl.handle.net/21.15107/rcub_rimi_1345"
}

Šarac, I., Debeljak-Martačić, J., Takić, M., Stevanović, V., Milešević, J., Zeković, M., Popović, T. B., Jovanović, J.,& Kardum Vidović, N.. (2023). Associations of fatty acids composition and estimated desaturase activities in erythrocyte phospholipids with biochemical and clinical indicators of cardiometabolic risk in non-diabetic Serbian women: the role of level of adiposity. in Frontiers in Nutrition
Frontiers Media S.A.., 10.
https://doi.org/10.3389/fnut.2023.1065578
https://hdl.handle.net/21.15107/rcub_rimi_1345

Šarac I, Debeljak-Martačić J, Takić M, Stevanović V, Milešević J, Zeković M, Popović TB, Jovanović J, Kardum Vidović N. Associations of fatty acids composition and estimated desaturase activities in erythrocyte phospholipids with biochemical and clinical indicators of cardiometabolic risk in non-diabetic Serbian women: the role of level of adiposity. in Frontiers in Nutrition. 2023;10.
doi:10.3389/fnut.2023.1065578
https://hdl.handle.net/21.15107/rcub_rimi_1345 .

Šarac, Ivana, Debeljak-Martačić, Jasmina, Takić, Marija, Stevanović, Vuk, Milešević, Jelena, Zeković, Milica, Popović, Tamara B., Jovanović, Jovica, Kardum Vidović, Nevena, "Associations of fatty acids composition and estimated desaturase activities in erythrocyte phospholipids with biochemical and clinical indicators of cardiometabolic risk in non-diabetic Serbian women: the role of level of adiposity" in Frontiers in Nutrition, 10 (2023),
https://doi.org/10.3389/fnut.2023.1065578 .,
https://hdl.handle.net/21.15107/rcub_rimi_1345 .

TY  - JOUR
AU  - Vidović, Nevena Đ.
AU  - Knez, Marija
AU  - Ranić, Marija M.
AU  - Faid, Fathia
AU  - Jović, Dragana
AU  - Glibetić, Marija
AU  - Takić, Marija
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1362
AB  - Aim: Cardiovascular diseases (CVDs) represent the major cause of morbidity and mortality worldwide including Libya, where they account for 43% of all deaths. Sphingolipids are involved in the pathology of numerous diseases including cardiovascular diseases and are proposed as potential biomarkers of cardiovascular health that could be more effective compared to traditional clinical biomarkers. The aim of this study was to determine the sphingolipid content in the erythrocyte membrane of Libyan migrant and Serbian resident women. In addition, to examine if sphingolipid levels could be used as a novel indicator of cardiovascular risk, we evaluated possible correlations with some well-established biomarkers of cardiovascular health. Materials and Methods: A total of 13 Libyan and 15 Serbian healthy women participated in the study. The high-performance version thin-layer chromatography (HPTLC) using the image analysis tool JustTLC was applied for quantification of erythrocytes’ sphingolipids. Results: Lower mean values of erythrocytes’ sphingolipids and cholesterol concentrations were found in the group of Libyan emigrants compared to Serbian resident women. Besides, in this group of apparently healthy women (n = 28), the sphingolipid content of erythrocytes was inversely related to the Omega-3 index (r =-0.492, p = 0.008) and directly linked to vitamin D status (r = 0.433, p = 0.021) and membrane cholesterol levels (r = 0.474, p = 0.011). Conclusion: The erythrocytes’ sphingolipid levels should be measured/assessed as an additional biomarker of CV health, by applying a simple and routine method. Still, further investigation in a larger population-specific context is warranted.
PB  - Taylor & Francis
T2  - Libyan Journal of Medicine
T2  - Libyan Journal of Medicine
T1  - Comparative assessment of erythrocyte sphingolipid levels as potential cardiovascular health markers in women from Libya and Serbia: a small-scale study
IS  - 1
SP  - 2264568
VL  - 18
DO  - 10.1080/19932820.2023.2264568
ER  - 

@article{
author = "Vidović, Nevena Đ. and Knez, Marija and Ranić, Marija M. and Faid, Fathia and Jović, Dragana and Glibetić, Marija and Takić, Marija",
year = "2023",
abstract = "Aim: Cardiovascular diseases (CVDs) represent the major cause of morbidity and mortality worldwide including Libya, where they account for 43% of all deaths. Sphingolipids are involved in the pathology of numerous diseases including cardiovascular diseases and are proposed as potential biomarkers of cardiovascular health that could be more effective compared to traditional clinical biomarkers. The aim of this study was to determine the sphingolipid content in the erythrocyte membrane of Libyan migrant and Serbian resident women. In addition, to examine if sphingolipid levels could be used as a novel indicator of cardiovascular risk, we evaluated possible correlations with some well-established biomarkers of cardiovascular health. Materials and Methods: A total of 13 Libyan and 15 Serbian healthy women participated in the study. The high-performance version thin-layer chromatography (HPTLC) using the image analysis tool JustTLC was applied for quantification of erythrocytes’ sphingolipids. Results: Lower mean values of erythrocytes’ sphingolipids and cholesterol concentrations were found in the group of Libyan emigrants compared to Serbian resident women. Besides, in this group of apparently healthy women (n = 28), the sphingolipid content of erythrocytes was inversely related to the Omega-3 index (r =-0.492, p = 0.008) and directly linked to vitamin D status (r = 0.433, p = 0.021) and membrane cholesterol levels (r = 0.474, p = 0.011). Conclusion: The erythrocytes’ sphingolipid levels should be measured/assessed as an additional biomarker of CV health, by applying a simple and routine method. Still, further investigation in a larger population-specific context is warranted.",
publisher = "Taylor & Francis",
journal = "Libyan Journal of Medicine, Libyan Journal of Medicine",
title = "Comparative assessment of erythrocyte sphingolipid levels as potential cardiovascular health markers in women from Libya and Serbia: a small-scale study",
number = "1",
pages = "2264568",
volume = "18",
doi = "10.1080/19932820.2023.2264568"
}

Vidović, N. Đ., Knez, M., Ranić, M. M., Faid, F., Jović, D., Glibetić, M.,& Takić, M.. (2023). Comparative assessment of erythrocyte sphingolipid levels as potential cardiovascular health markers in women from Libya and Serbia: a small-scale study. in Libyan Journal of Medicine
Taylor & Francis., 18(1), 2264568.
https://doi.org/10.1080/19932820.2023.2264568

Vidović NĐ, Knez M, Ranić MM, Faid F, Jović D, Glibetić M, Takić M. Comparative assessment of erythrocyte sphingolipid levels as potential cardiovascular health markers in women from Libya and Serbia: a small-scale study. in Libyan Journal of Medicine. 2023;18(1):2264568.
doi:10.1080/19932820.2023.2264568 .

Vidović, Nevena Đ., Knez, Marija, Ranić, Marija M., Faid, Fathia, Jović, Dragana, Glibetić, Marija, Takić, Marija, "Comparative assessment of erythrocyte sphingolipid levels as potential cardiovascular health markers in women from Libya and Serbia: a small-scale study" in Libyan Journal of Medicine, 18, no. 1 (2023):2264568,
https://doi.org/10.1080/19932820.2023.2264568 . .

TY  - JOUR
AU  - Petrović-Oggiano, Gordana P.
AU  - Pokimica, Biljana
AU  - Popović, Tamara B.
AU  - Takić, Marija
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1286
AB  - Our focus was to obtain an overall picture of the different beneficial properties of zeolite, based on its chemical and physical characteristics, which depend on zeolite absorption and exchange of ions. These characteristics make them very useful for various applications, including agriculture (as an animal feed additive and in food technology production), veterinary and human medicine, ecology, certain manufacturing, and cosmetics. Zeolite has pleiotropic effects, and the most important of them are detoxifying, antioxidant, and anti-inflammatory roles. We wanted to underline, with the review of the scientific literature, the positive medical beneficial effects of zeolite on the general health status.
PB  - Codon Publications
T2  - Italian Journal of Food Science
T1  - Beneficial properties of zeolite
EP  - 78
IS  - 1
SP  - 72
VL  - 35
DO  - 10.15586/ijfs.v35i1.2325
ER  - 

@article{
author = "Petrović-Oggiano, Gordana P. and Pokimica, Biljana and Popović, Tamara B. and Takić, Marija",
year = "2023",
abstract = "Our focus was to obtain an overall picture of the different beneficial properties of zeolite, based on its chemical and physical characteristics, which depend on zeolite absorption and exchange of ions. These characteristics make them very useful for various applications, including agriculture (as an animal feed additive and in food technology production), veterinary and human medicine, ecology, certain manufacturing, and cosmetics. Zeolite has pleiotropic effects, and the most important of them are detoxifying, antioxidant, and anti-inflammatory roles. We wanted to underline, with the review of the scientific literature, the positive medical beneficial effects of zeolite on the general health status.",
publisher = "Codon Publications",
journal = "Italian Journal of Food Science",
title = "Beneficial properties of zeolite",
pages = "78-72",
number = "1",
volume = "35",
doi = "10.15586/ijfs.v35i1.2325"
}

Petrović-Oggiano, G. P., Pokimica, B., Popović, T. B.,& Takić, M.. (2023). Beneficial properties of zeolite. in Italian Journal of Food Science
Codon Publications., 35(1), 72-78.
https://doi.org/10.15586/ijfs.v35i1.2325

Petrović-Oggiano GP, Pokimica B, Popović TB, Takić M. Beneficial properties of zeolite. in Italian Journal of Food Science. 2023;35(1):72-78.
doi:10.15586/ijfs.v35i1.2325 .

Petrović-Oggiano, Gordana P., Pokimica, Biljana, Popović, Tamara B., Takić, Marija, "Beneficial properties of zeolite" in Italian Journal of Food Science, 35, no. 1 (2023):72-78,
https://doi.org/10.15586/ijfs.v35i1.2325 . .

TY  - JOUR
AU  - Vasović, Dolika D.
AU  - Vesković, Milena
AU  - Šutulović, Nikola
AU  - Hrnčić, Dragan
AU  - Takić, Marija
AU  - Jerotić, Đurđa
AU  - Matić, Marija
AU  - Stanojlović, Olivera
AU  - Ivković, Sanja
AU  - Jovanović Macura, Irena
AU  - Mladenović, Dušan
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1305
AB  - The aim of our study was to investigate the effects of a shortened daily photoperiod on anxiety-like behaviour, brain oxidative stress, lipid status and fatty acid composition of serum lipids in a streptozotocin (STZ)-induced model of diabetes mellitus in rats. Male Wistar rats were divided into the following groups: first group—control group (C12/12); second group—diabetic group (DM12/12; 100 mg/kg STZ); third group—control group exposed to a light/dark cycle 6/18 h (C6/18); fourth group—diabetic group exposed to a light/dark cycle 6/18 h (DM6/18). Anxiety-like behaviour was tested three weeks following STZ injection by elevated plus maze (EPM) and open-field test (OFT). Oxidative stress parameters were measured in the cortex, hippocampus and thalamus, while lipid status and fatty acid methyl esters (FAMEs) were measured in the serum. Both EPM and OFT showed a lower degree of anxiety-like behaviour in the DM6/18 vs. DM12/12 group. Lipid peroxidation in the cortex, hippocampus and thalamus was significantly lower in the DM6/18 vs. DM12/12 group (p < 0.05), associated with an increased level of antioxidant enzymes and protein thiols in the cortex and thalamus. In the DM6/18 group, oleic, vaccenic, dihomo-γ-linolenic and docosahexaenoic acid concentrations were significantly higher in comparison to the DM12/12 group. A shortened daily photoperiod alleviates anxiety-like behaviour in diabetic rats by reduced lipid peroxidation and changes in the serum fatty acids profile.
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Journal of Personalized Medicine
T1  - Shortened Daily Photoperiod Alleviates Anxiety-like Behaviour by Antioxidant Effect and Changes Serum Fatty Acid Profile in Diabetic Rats
IS  - 5
SP  - 744
VL  - 13
DO  - 10.3390/jpm13050744
ER  - 

@article{
author = "Vasović, Dolika D. and Vesković, Milena and Šutulović, Nikola and Hrnčić, Dragan and Takić, Marija and Jerotić, Đurđa and Matić, Marija and Stanojlović, Olivera and Ivković, Sanja and Jovanović Macura, Irena and Mladenović, Dušan",
year = "2023",
abstract = "The aim of our study was to investigate the effects of a shortened daily photoperiod on anxiety-like behaviour, brain oxidative stress, lipid status and fatty acid composition of serum lipids in a streptozotocin (STZ)-induced model of diabetes mellitus in rats. Male Wistar rats were divided into the following groups: first group—control group (C12/12); second group—diabetic group (DM12/12; 100 mg/kg STZ); third group—control group exposed to a light/dark cycle 6/18 h (C6/18); fourth group—diabetic group exposed to a light/dark cycle 6/18 h (DM6/18). Anxiety-like behaviour was tested three weeks following STZ injection by elevated plus maze (EPM) and open-field test (OFT). Oxidative stress parameters were measured in the cortex, hippocampus and thalamus, while lipid status and fatty acid methyl esters (FAMEs) were measured in the serum. Both EPM and OFT showed a lower degree of anxiety-like behaviour in the DM6/18 vs. DM12/12 group. Lipid peroxidation in the cortex, hippocampus and thalamus was significantly lower in the DM6/18 vs. DM12/12 group (p < 0.05), associated with an increased level of antioxidant enzymes and protein thiols in the cortex and thalamus. In the DM6/18 group, oleic, vaccenic, dihomo-γ-linolenic and docosahexaenoic acid concentrations were significantly higher in comparison to the DM12/12 group. A shortened daily photoperiod alleviates anxiety-like behaviour in diabetic rats by reduced lipid peroxidation and changes in the serum fatty acids profile.",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Journal of Personalized Medicine",
title = "Shortened Daily Photoperiod Alleviates Anxiety-like Behaviour by Antioxidant Effect and Changes Serum Fatty Acid Profile in Diabetic Rats",
number = "5",
pages = "744",
volume = "13",
doi = "10.3390/jpm13050744"
}

Vasović, D. D., Vesković, M., Šutulović, N., Hrnčić, D., Takić, M., Jerotić, Đ., Matić, M., Stanojlović, O., Ivković, S., Jovanović Macura, I.,& Mladenović, D.. (2023). Shortened Daily Photoperiod Alleviates Anxiety-like Behaviour by Antioxidant Effect and Changes Serum Fatty Acid Profile in Diabetic Rats. in Journal of Personalized Medicine
Multidisciplinary Digital Publishing Institute (MDPI)., 13(5), 744.
https://doi.org/10.3390/jpm13050744

Vasović DD, Vesković M, Šutulović N, Hrnčić D, Takić M, Jerotić Đ, Matić M, Stanojlović O, Ivković S, Jovanović Macura I, Mladenović D. Shortened Daily Photoperiod Alleviates Anxiety-like Behaviour by Antioxidant Effect and Changes Serum Fatty Acid Profile in Diabetic Rats. in Journal of Personalized Medicine. 2023;13(5):744.
doi:10.3390/jpm13050744 .

Vasović, Dolika D., Vesković, Milena, Šutulović, Nikola, Hrnčić, Dragan, Takić, Marija, Jerotić, Đurđa, Matić, Marija, Stanojlović, Olivera, Ivković, Sanja, Jovanović Macura, Irena, Mladenović, Dušan, "Shortened Daily Photoperiod Alleviates Anxiety-like Behaviour by Antioxidant Effect and Changes Serum Fatty Acid Profile in Diabetic Rats" in Journal of Personalized Medicine, 13, no. 5 (2023):744,
https://doi.org/10.3390/jpm13050744 . .

TY  - JOUR
AU  - Ristić-Medić, Danijela
AU  - Petrović, Snježana
AU  - Polak, Tomaž
AU  - Bertoncelj, Jasna
AU  - Arsić, Aleksandra
AU  - Takić, Marija
AU  - Vučić, Vesna M.
AU  - Gurinović, Mirjana
AU  - Korošec, Mojca
PY  - 2022
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1232
AB  - Objectives: Industrially produced trans fatty acid (iTFA) have adverse health effects and thus their consumption should be limited. The aim of this study was to determine and compare the iTFA content in frequently consumed food products by young adults from the Serbian and Slovenian market with supposedly elevated iTFA content in 2015. At the time of this study, there was no recommended limit of iTFA in both countries, and reduction of iTFA in foods was on voluntary basis.Methods: We determined iTFA content in food products, 19 from the Serbian and 22 from the Slovenian market, blinded and analysed in the same analytical run. Contents of fatty acids (FA) methyl esters were analysed by capillary gas chromatography with a flame ionisation detector. Heptadecanoic acid was used as internal standard. Individual FA along with TFA were expressed as percentages of total measured FA. The amount of each FA in the sample was then calculated from the response factor and the transformation factor of the FA from the FA methyl ester content.Results: Elaidic acid (C18:1t) was found as the most abundant TFA in analysed products, ranging from 0.52 g/100 g of total FA in chocolate candy up to 60.4 g/100 g in a salami from Serbian market. In Slovenian products, the values for elaidic acid were lower, 0.04-3.95 g/100 g of total FA, except in one type of wafers (24.3 g/100 g).Conclusions: The majority of analysed products from the Serbian and three from Slovenian market exceeded the recommended WHO and EU limit of 2% iTFA of total fat in foods. Samples of frequently consumed salami, wafers, tea biscuits, and snacks were identified as products with potentially higher burden of iTFA in diets of young adults in Serbia.
T2  - Central European Journal of Public Health
T2  - Central European Journal of Public Health
T1  - Trans fatty acids in frequently consumed products from Serbian and Slovenian market
EP  - 57
IS  - 1
SP  - 51
VL  - 30
DO  - 10.21101/cejph.a5928
DO  - 10.21101/cejph.a5928
ER  - 

@article{
author = "Ristić-Medić, Danijela and Petrović, Snježana and Polak, Tomaž and Bertoncelj, Jasna and Arsić, Aleksandra and Takić, Marija and Vučić, Vesna M. and Gurinović, Mirjana and Korošec, Mojca",
year = "2022",
abstract = "Objectives: Industrially produced trans fatty acid (iTFA) have adverse health effects and thus their consumption should be limited. The aim of this study was to determine and compare the iTFA content in frequently consumed food products by young adults from the Serbian and Slovenian market with supposedly elevated iTFA content in 2015. At the time of this study, there was no recommended limit of iTFA in both countries, and reduction of iTFA in foods was on voluntary basis.Methods: We determined iTFA content in food products, 19 from the Serbian and 22 from the Slovenian market, blinded and analysed in the same analytical run. Contents of fatty acids (FA) methyl esters were analysed by capillary gas chromatography with a flame ionisation detector. Heptadecanoic acid was used as internal standard. Individual FA along with TFA were expressed as percentages of total measured FA. The amount of each FA in the sample was then calculated from the response factor and the transformation factor of the FA from the FA methyl ester content.Results: Elaidic acid (C18:1t) was found as the most abundant TFA in analysed products, ranging from 0.52 g/100 g of total FA in chocolate candy up to 60.4 g/100 g in a salami from Serbian market. In Slovenian products, the values for elaidic acid were lower, 0.04-3.95 g/100 g of total FA, except in one type of wafers (24.3 g/100 g).Conclusions: The majority of analysed products from the Serbian and three from Slovenian market exceeded the recommended WHO and EU limit of 2% iTFA of total fat in foods. Samples of frequently consumed salami, wafers, tea biscuits, and snacks were identified as products with potentially higher burden of iTFA in diets of young adults in Serbia.",
journal = "Central European Journal of Public Health, Central European Journal of Public Health",
title = "Trans fatty acids in frequently consumed products from Serbian and Slovenian market",
pages = "57-51",
number = "1",
volume = "30",
doi = "10.21101/cejph.a5928, 10.21101/cejph.a5928"
}

Ristić-Medić, D., Petrović, S., Polak, T., Bertoncelj, J., Arsić, A., Takić, M., Vučić, V. M., Gurinović, M.,& Korošec, M.. (2022). Trans fatty acids in frequently consumed products from Serbian and Slovenian market. in Central European Journal of Public Health, 30(1), 51-57.
https://doi.org/10.21101/cejph.a5928

Ristić-Medić D, Petrović S, Polak T, Bertoncelj J, Arsić A, Takić M, Vučić VM, Gurinović M, Korošec M. Trans fatty acids in frequently consumed products from Serbian and Slovenian market. in Central European Journal of Public Health. 2022;30(1):51-57.
doi:10.21101/cejph.a5928 .

Ristić-Medić, Danijela, Petrović, Snježana, Polak, Tomaž, Bertoncelj, Jasna, Arsić, Aleksandra, Takić, Marija, Vučić, Vesna M., Gurinović, Mirjana, Korošec, Mojca, "Trans fatty acids in frequently consumed products from Serbian and Slovenian market" in Central European Journal of Public Health, 30, no. 1 (2022):51-57,
https://doi.org/10.21101/cejph.a5928 . .

TY  - JOUR
AU  - Ristić-Medić, Danijela
AU  - Petrović, Snježana
AU  - Takić, Marija
AU  - Vučić, Vesna
AU  - Arsić, Aleksandra
AU  - Rađen, Slavica
AU  - Glibetić, Marija
PY  - 2022
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1338
AB  - Polyunsaturated fatty acid (PUFA) dietary intake, status and serum key fatty acid
(FA) ratios may aid in cardiovascular disease-related risk assessment. The aim of this study was to investigate
the effects of lipid-lowering diet on key FA ratios in serum phospholipids and omega-3 index in
erythrocyte phospholipids in moderately hyperlipidemic subjects. The study included 41 subjects, mean
age 56±6 years. Nutritional habits were evaluated by food frequency questionnaire. Participants followed
lipid lowering diet for 12 weeks. Energy intake of omega-6 and omega-3 FA was changed from 7.6%
and 0.6% to 5.7% and 1.2%, respectively. Marked decrease in four FA ratios in serum phospholipids,
i.e., omega-6/omega-3, arachidonic acid (AA)/eicosapentaenoic acid (EPA), AA/docosahexaenoic acid
(DHA), AA/(EPA+DHA) and omega-3 index (EPA+DHA) was found in study subjects after lipid-
lowering diet. Total cholesterol/high-density lipoprotein (HDL), low-density lipoprotein (LDL)/
HDL and triacylglycerol/HDL-cholesterol ratios positively correlated with all FA ratios, and negatively
correlated with total omega-3 levels in serum phospholipids and omega-3 index in erythrocytes. Total
serum omega-3 levels showed strongest association with lipoprotein ratios and positive correlation with
homeostatic model assessment (HOMA) index. In conclusion, lipid-lowering diet resulted in decreased
serum key FA ratios, increased omega-3 levels, and improved insulin sensitivity that may lead to a lower
risk of cardiovascular disease in subjects with moderate hyperlipidemia.
PB  - Klinicka bolnica Sestre Milosrdnice
T2  - Acta clinica Croatica
T1  - Efficacy of a Lipid-Lowering Diet on Key Fatty Acid Ratios and Omega-3 Index in Hyperlipidemic Subjects
EP  - 226
IS  - 2
SP  - 220
VL  - 61
DO  - 10.20471/acc.2022.61.02.08
ER  - 

@article{
author = "Ristić-Medić, Danijela and Petrović, Snježana and Takić, Marija and Vučić, Vesna and Arsić, Aleksandra and Rađen, Slavica and Glibetić, Marija",
year = "2022",
abstract = "Polyunsaturated fatty acid (PUFA) dietary intake, status and serum key fatty acid
(FA) ratios may aid in cardiovascular disease-related risk assessment. The aim of this study was to investigate
the effects of lipid-lowering diet on key FA ratios in serum phospholipids and omega-3 index in
erythrocyte phospholipids in moderately hyperlipidemic subjects. The study included 41 subjects, mean
age 56±6 years. Nutritional habits were evaluated by food frequency questionnaire. Participants followed
lipid lowering diet for 12 weeks. Energy intake of omega-6 and omega-3 FA was changed from 7.6%
and 0.6% to 5.7% and 1.2%, respectively. Marked decrease in four FA ratios in serum phospholipids,
i.e., omega-6/omega-3, arachidonic acid (AA)/eicosapentaenoic acid (EPA), AA/docosahexaenoic acid
(DHA), AA/(EPA+DHA) and omega-3 index (EPA+DHA) was found in study subjects after lipid-
lowering diet. Total cholesterol/high-density lipoprotein (HDL), low-density lipoprotein (LDL)/
HDL and triacylglycerol/HDL-cholesterol ratios positively correlated with all FA ratios, and negatively
correlated with total omega-3 levels in serum phospholipids and omega-3 index in erythrocytes. Total
serum omega-3 levels showed strongest association with lipoprotein ratios and positive correlation with
homeostatic model assessment (HOMA) index. In conclusion, lipid-lowering diet resulted in decreased
serum key FA ratios, increased omega-3 levels, and improved insulin sensitivity that may lead to a lower
risk of cardiovascular disease in subjects with moderate hyperlipidemia.",
publisher = "Klinicka bolnica Sestre Milosrdnice",
journal = "Acta clinica Croatica",
title = "Efficacy of a Lipid-Lowering Diet on Key Fatty Acid Ratios and Omega-3 Index in Hyperlipidemic Subjects",
pages = "226-220",
number = "2",
volume = "61",
doi = "10.20471/acc.2022.61.02.08"
}

Ristić-Medić, D., Petrović, S., Takić, M., Vučić, V., Arsić, A., Rađen, S.,& Glibetić, M.. (2022). Efficacy of a Lipid-Lowering Diet on Key Fatty Acid Ratios and Omega-3 Index in Hyperlipidemic Subjects. in Acta clinica Croatica
Klinicka bolnica Sestre Milosrdnice., 61(2), 220-226.
https://doi.org/10.20471/acc.2022.61.02.08

Ristić-Medić D, Petrović S, Takić M, Vučić V, Arsić A, Rađen S, Glibetić M. Efficacy of a Lipid-Lowering Diet on Key Fatty Acid Ratios and Omega-3 Index in Hyperlipidemic Subjects. in Acta clinica Croatica. 2022;61(2):220-226.
doi:10.20471/acc.2022.61.02.08 .

Ristić-Medić, Danijela, Petrović, Snježana, Takić, Marija, Vučić, Vesna, Arsić, Aleksandra, Rađen, Slavica, Glibetić, Marija, "Efficacy of a Lipid-Lowering Diet on Key Fatty Acid Ratios and Omega-3 Index in Hyperlipidemic Subjects" in Acta clinica Croatica, 61, no. 2 (2022):220-226,
https://doi.org/10.20471/acc.2022.61.02.08 . .

TY  - CONF
AU  - Šarac, Ivana
AU  - Milešević, Jelena
AU  - Takić, Marija
AU  - Petrović Oggiano, Gordana
AU  - Pokimica, Biljana
AU  - Popović, Tamara
AU  - Debeljak Martačić, Jasmina
PY  - 2022
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1430
PB  - Magnus Group (MG)
C3  - 3rd edition of International Nutrition Research Conference 12-13 September, 2022 - Book of Abstracts
T1  - Correlations of fatty acids profiles in erythrocyte phospholipids and estimated desaturases activities with cadiometabolic risk indicators in non-diabetic women
EP  - 28
SP  - 27
UR  - https://hdl.handle.net/21.15107/rcub_rimi_1430
ER  - 

@conference{
author = "Šarac, Ivana and Milešević, Jelena and Takić, Marija and Petrović Oggiano, Gordana and Pokimica, Biljana and Popović, Tamara and Debeljak Martačić, Jasmina",
year = "2022",
publisher = "Magnus Group (MG)",
journal = "3rd edition of International Nutrition Research Conference 12-13 September, 2022 - Book of Abstracts",
title = "Correlations of fatty acids profiles in erythrocyte phospholipids and estimated desaturases activities with cadiometabolic risk indicators in non-diabetic women",
pages = "28-27",
url = "https://hdl.handle.net/21.15107/rcub_rimi_1430"
}

Šarac, I., Milešević, J., Takić, M., Petrović Oggiano, G., Pokimica, B., Popović, T.,& Debeljak Martačić, J.. (2022). Correlations of fatty acids profiles in erythrocyte phospholipids and estimated desaturases activities with cadiometabolic risk indicators in non-diabetic women. in 3rd edition of International Nutrition Research Conference 12-13 September, 2022 - Book of Abstracts
Magnus Group (MG)., 27-28.
https://hdl.handle.net/21.15107/rcub_rimi_1430

Šarac I, Milešević J, Takić M, Petrović Oggiano G, Pokimica B, Popović T, Debeljak Martačić J. Correlations of fatty acids profiles in erythrocyte phospholipids and estimated desaturases activities with cadiometabolic risk indicators in non-diabetic women. in 3rd edition of International Nutrition Research Conference 12-13 September, 2022 - Book of Abstracts. 2022;:27-28.
https://hdl.handle.net/21.15107/rcub_rimi_1430 .

Šarac, Ivana, Milešević, Jelena, Takić, Marija, Petrović Oggiano, Gordana, Pokimica, Biljana, Popović, Tamara, Debeljak Martačić, Jasmina, "Correlations of fatty acids profiles in erythrocyte phospholipids and estimated desaturases activities with cadiometabolic risk indicators in non-diabetic women" in 3rd edition of International Nutrition Research Conference 12-13 September, 2022 - Book of Abstracts (2022):27-28,
https://hdl.handle.net/21.15107/rcub_rimi_1430 .

TY  - JOUR
AU  - Zeković, Milica
AU  - Milešević, Jelena
AU  - Takić, Marija
AU  - Knez, Marija
AU  - Šarac, Ivana
AU  - Kadvan, Agnes
AU  - Gurinović, Mirjana
AU  - Glibetić, Marija
PY  - 2022
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1253
AB  - The Serbian Food Consumption Survey among 1–9-year-old-children was conceptualized and conducted in compliance with the principles, established protocols, and guidelines of the EU Menu project between 2017 and 2021. Valid data were collected for 576 individuals (290 1–3-year-old toddlers and 276 3–9-year-old children). Regardless of age and gender category, the majority (68.80%) of children had normal weights according to the Body Mass Index-for-age classification system. The median daily energy intake was 1406.71 kcal with no differences between the settlement types. The overall median contributions of carbohydrates, protein, and fat to the total energy intake were 47.54%, 14.06%, and 37.88%, respectively. The proportions of the macronutrient intake deviated from the dietary reference values with compliance to the recommendations being particularly poor for fat and fiber. The consumption of energy-dense food groups such as meat and meat products, fat and oil, sugar, and confections was more pronounced among older children. The survey results provide a valuable insight into the nutritional status and dietary habits of toddlers and children 1–9 years old living in Serbia. They may serve as an evidence platform for public health programs, a valuable asset for decision-makers, and a reliable reference to guide nutritional policies, diet monitoring, and interventions targeting this population group in the future.
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Nutrients
T1  - Evaluation of Dietary Intake and Anthropometric Status in 1–9-Year-Old Children Living in Serbia: National Food Consumption Survey according to the EU Menu Methodology
IS  - 15
SP  - 3091
VL  - 14
DO  - 10.3390/nu14153091
ER  - 

@article{
author = "Zeković, Milica and Milešević, Jelena and Takić, Marija and Knez, Marija and Šarac, Ivana and Kadvan, Agnes and Gurinović, Mirjana and Glibetić, Marija",
year = "2022",
abstract = "The Serbian Food Consumption Survey among 1–9-year-old-children was conceptualized and conducted in compliance with the principles, established protocols, and guidelines of the EU Menu project between 2017 and 2021. Valid data were collected for 576 individuals (290 1–3-year-old toddlers and 276 3–9-year-old children). Regardless of age and gender category, the majority (68.80%) of children had normal weights according to the Body Mass Index-for-age classification system. The median daily energy intake was 1406.71 kcal with no differences between the settlement types. The overall median contributions of carbohydrates, protein, and fat to the total energy intake were 47.54%, 14.06%, and 37.88%, respectively. The proportions of the macronutrient intake deviated from the dietary reference values with compliance to the recommendations being particularly poor for fat and fiber. The consumption of energy-dense food groups such as meat and meat products, fat and oil, sugar, and confections was more pronounced among older children. The survey results provide a valuable insight into the nutritional status and dietary habits of toddlers and children 1–9 years old living in Serbia. They may serve as an evidence platform for public health programs, a valuable asset for decision-makers, and a reliable reference to guide nutritional policies, diet monitoring, and interventions targeting this population group in the future.",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Nutrients",
title = "Evaluation of Dietary Intake and Anthropometric Status in 1–9-Year-Old Children Living in Serbia: National Food Consumption Survey according to the EU Menu Methodology",
number = "15",
pages = "3091",
volume = "14",
doi = "10.3390/nu14153091"
}

Zeković, M., Milešević, J., Takić, M., Knez, M., Šarac, I., Kadvan, A., Gurinović, M.,& Glibetić, M.. (2022). Evaluation of Dietary Intake and Anthropometric Status in 1–9-Year-Old Children Living in Serbia: National Food Consumption Survey according to the EU Menu Methodology. in Nutrients
Multidisciplinary Digital Publishing Institute (MDPI)., 14(15), 3091.
https://doi.org/10.3390/nu14153091

Zeković M, Milešević J, Takić M, Knez M, Šarac I, Kadvan A, Gurinović M, Glibetić M. Evaluation of Dietary Intake and Anthropometric Status in 1–9-Year-Old Children Living in Serbia: National Food Consumption Survey according to the EU Menu Methodology. in Nutrients. 2022;14(15):3091.
doi:10.3390/nu14153091 .

Zeković, Milica, Milešević, Jelena, Takić, Marija, Knez, Marija, Šarac, Ivana, Kadvan, Agnes, Gurinović, Mirjana, Glibetić, Marija, "Evaluation of Dietary Intake and Anthropometric Status in 1–9-Year-Old Children Living in Serbia: National Food Consumption Survey according to the EU Menu Methodology" in Nutrients, 14, no. 15 (2022):3091,
https://doi.org/10.3390/nu14153091 . .

TY  - JOUR
AU  - Pokimica, Biljana
AU  - Popović, Tamara B.
AU  - Petrović-Oggiano, Gordana P.
AU  - Šarac, Ivana
AU  - Glibetić, Marija
AU  - Takić, Marija
PY  - 2022
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1337
AB  - One of the most popular dairy products worldwide is yogurt, which flavor is highly influenced by lactic acid content. Yogurts with fruit preparations contain polyphenols, secondary plant metabolites with proven antioxidant properties. As there is no data regarding neither lactate nor polyphenol content in commercial yogurts in Serbia, this study aimed to determine lactate and polyphenol levels, as well as antioxidant activity in selected yogurts. A total of 15 plain and 5 fruit yogurts with strawberry preparations were analyzed. Lactate contents were from 0.83 to 1.33%. Three plain yogurts in plastic containers differed in lactate content. There was no difference in lactate content among the same plain yogurts packed in plastic and Tetra Pack containers. Fruit yogurts with strawberry preparations differed in total polyphenol content in the range from 6.84 to 29.11mg GAE/100 g and antioxidant properties were determined by reducing power test (from 0.22 to 0.79) and DPPH assay (from 28.13 to 87.23%), while there was no difference regarding lactate. Our results provided new information about the levels of lactate, total polyphenols and antioxidant activity of selected commercial yogurts available on the Serbian market.
PB  - University of Novi Sad
T2  - Food and Feed Research
T2  - Food and Feed Research
T1  - Lactate content, total polyphenols and antioxidant activity of selected commercial yogurts from the Serbian market
EP  - 193
IS  - 2
SP  - 183
VL  - 49
DO  - 10.5937/ffr49-38791
ER  - 

@article{
author = "Pokimica, Biljana and Popović, Tamara B. and Petrović-Oggiano, Gordana P. and Šarac, Ivana and Glibetić, Marija and Takić, Marija",
year = "2022",
abstract = "One of the most popular dairy products worldwide is yogurt, which flavor is highly influenced by lactic acid content. Yogurts with fruit preparations contain polyphenols, secondary plant metabolites with proven antioxidant properties. As there is no data regarding neither lactate nor polyphenol content in commercial yogurts in Serbia, this study aimed to determine lactate and polyphenol levels, as well as antioxidant activity in selected yogurts. A total of 15 plain and 5 fruit yogurts with strawberry preparations were analyzed. Lactate contents were from 0.83 to 1.33%. Three plain yogurts in plastic containers differed in lactate content. There was no difference in lactate content among the same plain yogurts packed in plastic and Tetra Pack containers. Fruit yogurts with strawberry preparations differed in total polyphenol content in the range from 6.84 to 29.11mg GAE/100 g and antioxidant properties were determined by reducing power test (from 0.22 to 0.79) and DPPH assay (from 28.13 to 87.23%), while there was no difference regarding lactate. Our results provided new information about the levels of lactate, total polyphenols and antioxidant activity of selected commercial yogurts available on the Serbian market.",
publisher = "University of Novi Sad",
journal = "Food and Feed Research, Food and Feed Research",
title = "Lactate content, total polyphenols and antioxidant activity of selected commercial yogurts from the Serbian market",
pages = "193-183",
number = "2",
volume = "49",
doi = "10.5937/ffr49-38791"
}

Pokimica, B., Popović, T. B., Petrović-Oggiano, G. P., Šarac, I., Glibetić, M.,& Takić, M.. (2022). Lactate content, total polyphenols and antioxidant activity of selected commercial yogurts from the Serbian market. in Food and Feed Research
University of Novi Sad., 49(2), 183-193.
https://doi.org/10.5937/ffr49-38791

Pokimica B, Popović TB, Petrović-Oggiano GP, Šarac I, Glibetić M, Takić M. Lactate content, total polyphenols and antioxidant activity of selected commercial yogurts from the Serbian market. in Food and Feed Research. 2022;49(2):183-193.
doi:10.5937/ffr49-38791 .

Pokimica, Biljana, Popović, Tamara B., Petrović-Oggiano, Gordana P., Šarac, Ivana, Glibetić, Marija, Takić, Marija, "Lactate content, total polyphenols and antioxidant activity of selected commercial yogurts from the Serbian market" in Food and Feed Research, 49, no. 2 (2022):183-193,
https://doi.org/10.5937/ffr49-38791 . .

TY  - JOUR
AU  - Takić, Marija
AU  - Pokimica, Biljana
AU  - Petrović-Oggiano, Gordana P.
AU  - Popović, Tamara B.
PY  - 2022
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1339
AB  - The essential fatty acid alpha-linolenic acid (ALA) is present in high amounts in oils such as flaxseed, soy, hemp, rapeseed, chia, and perilla, while stearidonic acid is abundant in echium oil. ALA is metabolized to eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) by desaturases and elongases in humans. The conversion of ALA to EPA and DHA is limited, and these long-chain n−3 polyunsaturated fatty acids (PUFAs) are mainly provided from dietary sources (fish and seafood). This review provides an overview of studies that explored the effects of dietary supplementation with ALA in obesity and related diseases. The obesity-associated changes of desaturase and elongase activities are summarized, as they could influence the metabolic conversion of ALA. Generally, supplementation with ALA or ALA-rich oils leads to an increase in EPA levels and has no effect on DHA or omega-3 index. According to the literature data, stearidonic acid could enhance conversion of ALA to long-chain n−3 PUFA in obesity. Recent studies confirm that EPA and DHA intake should be considered as a primary dietary treatment strategy for improving the omega-3 index in obesity and related diseases.
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Molecules
T2  - Molecules
T1  - Effects of Dietary α-Linolenic Acid Treatment and the Efficiency of Its Conversion to Eicosapentaenoic and Docosahexaenoic Acids in Obesity and Related Diseases
IS  - 14
SP  - 4471
VL  - 27
DO  - 10.3390/molecules27144471
ER  - 

@article{
author = "Takić, Marija and Pokimica, Biljana and Petrović-Oggiano, Gordana P. and Popović, Tamara B.",
year = "2022",
abstract = "The essential fatty acid alpha-linolenic acid (ALA) is present in high amounts in oils such as flaxseed, soy, hemp, rapeseed, chia, and perilla, while stearidonic acid is abundant in echium oil. ALA is metabolized to eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) by desaturases and elongases in humans. The conversion of ALA to EPA and DHA is limited, and these long-chain n−3 polyunsaturated fatty acids (PUFAs) are mainly provided from dietary sources (fish and seafood). This review provides an overview of studies that explored the effects of dietary supplementation with ALA in obesity and related diseases. The obesity-associated changes of desaturase and elongase activities are summarized, as they could influence the metabolic conversion of ALA. Generally, supplementation with ALA or ALA-rich oils leads to an increase in EPA levels and has no effect on DHA or omega-3 index. According to the literature data, stearidonic acid could enhance conversion of ALA to long-chain n−3 PUFA in obesity. Recent studies confirm that EPA and DHA intake should be considered as a primary dietary treatment strategy for improving the omega-3 index in obesity and related diseases.",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Molecules, Molecules",
title = "Effects of Dietary α-Linolenic Acid Treatment and the Efficiency of Its Conversion to Eicosapentaenoic and Docosahexaenoic Acids in Obesity and Related Diseases",
number = "14",
pages = "4471",
volume = "27",
doi = "10.3390/molecules27144471"
}

Takić, M., Pokimica, B., Petrović-Oggiano, G. P.,& Popović, T. B.. (2022). Effects of Dietary α-Linolenic Acid Treatment and the Efficiency of Its Conversion to Eicosapentaenoic and Docosahexaenoic Acids in Obesity and Related Diseases. in Molecules
Multidisciplinary Digital Publishing Institute (MDPI)., 27(14), 4471.
https://doi.org/10.3390/molecules27144471

Takić M, Pokimica B, Petrović-Oggiano GP, Popović TB. Effects of Dietary α-Linolenic Acid Treatment and the Efficiency of Its Conversion to Eicosapentaenoic and Docosahexaenoic Acids in Obesity and Related Diseases. in Molecules. 2022;27(14):4471.
doi:10.3390/molecules27144471 .

Takić, Marija, Pokimica, Biljana, Petrović-Oggiano, Gordana P., Popović, Tamara B., "Effects of Dietary α-Linolenic Acid Treatment and the Efficiency of Its Conversion to Eicosapentaenoic and Docosahexaenoic Acids in Obesity and Related Diseases" in Molecules, 27, no. 14 (2022):4471,
https://doi.org/10.3390/molecules27144471 . .

TY  - JOUR
AU  - Arsić, Aleksandra
AU  - Takić, Marija
AU  - Kojadinović, Milica
AU  - Petrović, Snježana
AU  - Paunović, Marija P.
AU  - Vučić, Vesna M.
AU  - Ristić-Medić, Danijela
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1070
AB  - The aim of this study was to compare dietary intake and status of polyunsaturated fatty acids (PUFA) in plasma and erythrocyte phospholipids metabolically healthy and unhealthy, and obese and nonobese persons. Metabolic health status in 171 participants was defined according to criteria for metabolic syndrome. Obese and nonobese metabolically unhealthy persons (MUHO and MUHNO) had higher energy intake of n-6 PUFA (7.82 +/- 1.03 and 7.49 +/- 0.86) and lower intake of n-3 PUFA (0.60 +/- 0.12 and 0.62 +/- 0.11) compared to obese and nonobese metabolically healthy persons (MHO and MHNO) (5.92 +/- 0.63 and 5.72 +/- 0.67; 1.20 +/- 0.07 and 1.22 +/- 0.09, respectively) and a higher n-6/n-3 PUFA ratio. The plasma level of n-6 PUFA was lower in the MUHO and MUHNO groups (38.49 +/- 3.71 and 38.53 +/- 2.19) compared to MHNO (40.90 +/- 2.43), while n-3 PUFA status was lower in obese than in nonobese persons (3.58 +/- 0.79 and 3.50 +/- 1.02 vs. 4.21 +/- 0.80 and 4.06 +/- 1.15). The MHO group had a higher eicosapentaenoic/arachidonic acid ratio and estimated desaturase (SCD16, D6D) and elongase activity in plasma phospholipids compared to MHNO. The low intake of n-3 PUFA is directly associated with metabolic risk factors. These results indicated that obesity is closely associated with low levels of n-3 PUFA in plasma phospholipids, suggesting that dietary modifications including n-3 PUFA supplementation appear to be suitable therapeutic strategy in obese persons.
PB  - Canadian Science Publishing, Ottawa
T2  - Canadian Journal of Physiology & Pharmacology
T1  - Metabolically healthy obesity: is there a link with polyunsaturated fatty acid intake and status?
EP  - 71
IS  - 1
SP  - 64
VL  - 99
DO  - 10.1139/cjpp-2020-0317
ER  - 

@article{
author = "Arsić, Aleksandra and Takić, Marija and Kojadinović, Milica and Petrović, Snježana and Paunović, Marija P. and Vučić, Vesna M. and Ristić-Medić, Danijela",
year = "2021",
abstract = "The aim of this study was to compare dietary intake and status of polyunsaturated fatty acids (PUFA) in plasma and erythrocyte phospholipids metabolically healthy and unhealthy, and obese and nonobese persons. Metabolic health status in 171 participants was defined according to criteria for metabolic syndrome. Obese and nonobese metabolically unhealthy persons (MUHO and MUHNO) had higher energy intake of n-6 PUFA (7.82 +/- 1.03 and 7.49 +/- 0.86) and lower intake of n-3 PUFA (0.60 +/- 0.12 and 0.62 +/- 0.11) compared to obese and nonobese metabolically healthy persons (MHO and MHNO) (5.92 +/- 0.63 and 5.72 +/- 0.67; 1.20 +/- 0.07 and 1.22 +/- 0.09, respectively) and a higher n-6/n-3 PUFA ratio. The plasma level of n-6 PUFA was lower in the MUHO and MUHNO groups (38.49 +/- 3.71 and 38.53 +/- 2.19) compared to MHNO (40.90 +/- 2.43), while n-3 PUFA status was lower in obese than in nonobese persons (3.58 +/- 0.79 and 3.50 +/- 1.02 vs. 4.21 +/- 0.80 and 4.06 +/- 1.15). The MHO group had a higher eicosapentaenoic/arachidonic acid ratio and estimated desaturase (SCD16, D6D) and elongase activity in plasma phospholipids compared to MHNO. The low intake of n-3 PUFA is directly associated with metabolic risk factors. These results indicated that obesity is closely associated with low levels of n-3 PUFA in plasma phospholipids, suggesting that dietary modifications including n-3 PUFA supplementation appear to be suitable therapeutic strategy in obese persons.",
publisher = "Canadian Science Publishing, Ottawa",
journal = "Canadian Journal of Physiology & Pharmacology",
title = "Metabolically healthy obesity: is there a link with polyunsaturated fatty acid intake and status?",
pages = "71-64",
number = "1",
volume = "99",
doi = "10.1139/cjpp-2020-0317"
}

Arsić, A., Takić, M., Kojadinović, M., Petrović, S., Paunović, M. P., Vučić, V. M.,& Ristić-Medić, D.. (2021). Metabolically healthy obesity: is there a link with polyunsaturated fatty acid intake and status?. in Canadian Journal of Physiology & Pharmacology
Canadian Science Publishing, Ottawa., 99(1), 64-71.
https://doi.org/10.1139/cjpp-2020-0317

Arsić A, Takić M, Kojadinović M, Petrović S, Paunović MP, Vučić VM, Ristić-Medić D. Metabolically healthy obesity: is there a link with polyunsaturated fatty acid intake and status?. in Canadian Journal of Physiology & Pharmacology. 2021;99(1):64-71.
doi:10.1139/cjpp-2020-0317 .

Arsić, Aleksandra, Takić, Marija, Kojadinović, Milica, Petrović, Snježana, Paunović, Marija P., Vučić, Vesna M., Ristić-Medić, Danijela, "Metabolically healthy obesity: is there a link with polyunsaturated fatty acid intake and status?" in Canadian Journal of Physiology & Pharmacology, 99, no. 1 (2021):64-71,
https://doi.org/10.1139/cjpp-2020-0317 . .

TY  - JOUR
AU  - Ristić-Medić, Danijela
AU  - Kovačić, Marijana
AU  - Takić, Marija
AU  - Arsić, Aleksandra
AU  - Petrović, Snježana
AU  - Paunović, Marija P.
AU  - Jovicić, Maja
AU  - Vučić, Vesna M.
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1071
AB  - Lifestyle modifications are the main support of nonalcoholic fatty liver disease (NAFLD) therapy. Weight loss is one of the primary goals in NAFLD, but the effects of different calorie-restricted diets remain unclear. Thus, we evaluated the effects of two calorie-restricted diets-the Mediterranean diet (Med diet) and low-fat diet-on liver status, cardiometabolic markers, and fatty acid profiles in patients with NAFLD. Twenty-four overweight/moderately obese men were randomly assigned to consume one of these diets. Lipid levels, glucose, insulin, liver enzymes, steatosis, and fatty acid profiles of serum and erythrocytes phospholipids were assessed. After 3 months, all participants had a significant weight loss ( gt 9%), with improvements in waist circumference, body fat %, index of visceral adiposity (VAI), lipid accumulation product, fatty liver (FLI), and hepatic steatosis (HSI) index (p  lt  0.001). Both diets significantly lowered triglycerides, total and LDL-cholesterol, liver enzymes, fasting glucose, insulin, and HOMA-IR index. Fatty acid profiles were enhanced after both diets, with a significantly decreased n-6/n-3 ratio. Participants on the Med diet had higher levels of HDL-cholesterol and monounsaturated and n-3 docosahexaenoic acids in serum phospholipids and lower levels of saturated fatty acids, triglycerides, TG/HDL ratio, and FLI when compared to participants on the low-fat diet. Our results indicate that dietary patterns and calorie restriction represent central therapeutic issues in the improvement of obesity-related cardiometabolic alterations that are involved in the mechanism of hepatic steatosis. The Med diet may contribute to disease treatment even more than the low-fat diet since it leads to decreased saturated and increased monounsaturated and n-3 polyunsaturated fatty acid status and improved FLI in NAFLD patients.
PB  - MDPI
T2  - Nutrients
T1  - Calorie-Restricted Mediterranean and Low-Fat Diets Affect Fatty Acid Status in Individuals with Nonalcoholic Fatty Liver Disease
IS  - 1
SP  - 15
VL  - 13
DO  - 10.3390/nu13010015
ER  - 

@article{
author = "Ristić-Medić, Danijela and Kovačić, Marijana and Takić, Marija and Arsić, Aleksandra and Petrović, Snježana and Paunović, Marija P. and Jovicić, Maja and Vučić, Vesna M.",
year = "2021",
abstract = "Lifestyle modifications are the main support of nonalcoholic fatty liver disease (NAFLD) therapy. Weight loss is one of the primary goals in NAFLD, but the effects of different calorie-restricted diets remain unclear. Thus, we evaluated the effects of two calorie-restricted diets-the Mediterranean diet (Med diet) and low-fat diet-on liver status, cardiometabolic markers, and fatty acid profiles in patients with NAFLD. Twenty-four overweight/moderately obese men were randomly assigned to consume one of these diets. Lipid levels, glucose, insulin, liver enzymes, steatosis, and fatty acid profiles of serum and erythrocytes phospholipids were assessed. After 3 months, all participants had a significant weight loss ( gt 9%), with improvements in waist circumference, body fat %, index of visceral adiposity (VAI), lipid accumulation product, fatty liver (FLI), and hepatic steatosis (HSI) index (p  lt  0.001). Both diets significantly lowered triglycerides, total and LDL-cholesterol, liver enzymes, fasting glucose, insulin, and HOMA-IR index. Fatty acid profiles were enhanced after both diets, with a significantly decreased n-6/n-3 ratio. Participants on the Med diet had higher levels of HDL-cholesterol and monounsaturated and n-3 docosahexaenoic acids in serum phospholipids and lower levels of saturated fatty acids, triglycerides, TG/HDL ratio, and FLI when compared to participants on the low-fat diet. Our results indicate that dietary patterns and calorie restriction represent central therapeutic issues in the improvement of obesity-related cardiometabolic alterations that are involved in the mechanism of hepatic steatosis. The Med diet may contribute to disease treatment even more than the low-fat diet since it leads to decreased saturated and increased monounsaturated and n-3 polyunsaturated fatty acid status and improved FLI in NAFLD patients.",
publisher = "MDPI",
journal = "Nutrients",
title = "Calorie-Restricted Mediterranean and Low-Fat Diets Affect Fatty Acid Status in Individuals with Nonalcoholic Fatty Liver Disease",
number = "1",
pages = "15",
volume = "13",
doi = "10.3390/nu13010015"
}

Ristić-Medić, D., Kovačić, M., Takić, M., Arsić, A., Petrović, S., Paunović, M. P., Jovicić, M.,& Vučić, V. M.. (2021). Calorie-Restricted Mediterranean and Low-Fat Diets Affect Fatty Acid Status in Individuals with Nonalcoholic Fatty Liver Disease. in Nutrients
MDPI., 13(1), 15.
https://doi.org/10.3390/nu13010015

Ristić-Medić D, Kovačić M, Takić M, Arsić A, Petrović S, Paunović MP, Jovicić M, Vučić VM. Calorie-Restricted Mediterranean and Low-Fat Diets Affect Fatty Acid Status in Individuals with Nonalcoholic Fatty Liver Disease. in Nutrients. 2021;13(1):15.
doi:10.3390/nu13010015 .

Ristić-Medić, Danijela, Kovačić, Marijana, Takić, Marija, Arsić, Aleksandra, Petrović, Snježana, Paunović, Marija P., Jovicić, Maja, Vučić, Vesna M., "Calorie-Restricted Mediterranean and Low-Fat Diets Affect Fatty Acid Status in Individuals with Nonalcoholic Fatty Liver Disease" in Nutrients, 13, no. 1 (2021):15,
https://doi.org/10.3390/nu13010015 . .

TY  - JOUR
AU  - Rašić, Jelena S.
AU  - Ivanović, Nevena
AU  - Anđelković, Marija S.
AU  - Nedeljković, Ivana P.
AU  - Nikolic, Ivan R.
AU  - Stojanović, Sava D.
AU  - Ristić-Medić, Danijela
AU  - Takić, Marija
AU  - Đorđević, Brizita I.
AU  - Dikić, Nenad V.
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1170
AB  - The aim of this study was to determine the ergogenic effects and the safety profile of a one-component higenamine supplement in female recreational athletes. Twelve recreational female basketball players (age 29–41 years, oxygen consumption (VO2max) > 30 ml⋅kg–1⋅min–1, with training > 5 h wk–1) were randomized either to the higenamine group, or to the placebo group for 3 weeks. In order to determine ergogenic effects and safety profile of higenamine administration, we assessed the following variables before and after 3 weeks of supplementation: anthropometric parameters, resting metabolic rate (RMR), exercise testing variables, serum free fatty acids (FFAs), blood pressure, enzyme activity, urea, lipid profile, and complete blood count. There were no differences between groups in anthropometric parameters, including basal metabolic rate (BMR), RMR and body fat [p = 0.706 (Cohen’s d 0.223), p = 0.169 (Cohen’s d 0.857), and p = 0.223 (Cohen’s d 0.750), respectively], FFAs [0.43 ± 0.03 vs. 0.54 ± 0.23, p = 0.206 (Cohen’s d 0.540)], neither significant differences in cardiopulmonary parameters after the intervention period. Furthermore, all measured outcome variables in the safety assessment were not significant, with values remaining stable during the intervention period for participants in both groups. This is the first study to document the effects and the safety profile of higenamine-based dietary supplements at a specified dose in female recreational athletes. Our data indicate that 21-day of supplementation with 75 mg higenamine would not result in improving cardiopulmonary exercise fitness and weight loss in female recreational athletes. Moreover, supplementation with 75 mg higenamine is safe and well-tolerated in younger recreational female athletes.
PB  - Frontiers Media S.A.
T2  - Frontiers in Psychology
T1  - Influence of Higenamine on Exercise Performance of Recreational Female Athletes: A Randomized Double-Blinded Placebo-Controlled Trial
SP  - 633110
VL  - 12
DO  - 10.3389/fpsyg.2021.633110
ER  - 

@article{
author = "Rašić, Jelena S. and Ivanović, Nevena and Anđelković, Marija S. and Nedeljković, Ivana P. and Nikolic, Ivan R. and Stojanović, Sava D. and Ristić-Medić, Danijela and Takić, Marija and Đorđević, Brizita I. and Dikić, Nenad V.",
year = "2021",
abstract = "The aim of this study was to determine the ergogenic effects and the safety profile of a one-component higenamine supplement in female recreational athletes. Twelve recreational female basketball players (age 29–41 years, oxygen consumption (VO2max) > 30 ml⋅kg–1⋅min–1, with training > 5 h wk–1) were randomized either to the higenamine group, or to the placebo group for 3 weeks. In order to determine ergogenic effects and safety profile of higenamine administration, we assessed the following variables before and after 3 weeks of supplementation: anthropometric parameters, resting metabolic rate (RMR), exercise testing variables, serum free fatty acids (FFAs), blood pressure, enzyme activity, urea, lipid profile, and complete blood count. There were no differences between groups in anthropometric parameters, including basal metabolic rate (BMR), RMR and body fat [p = 0.706 (Cohen’s d 0.223), p = 0.169 (Cohen’s d 0.857), and p = 0.223 (Cohen’s d 0.750), respectively], FFAs [0.43 ± 0.03 vs. 0.54 ± 0.23, p = 0.206 (Cohen’s d 0.540)], neither significant differences in cardiopulmonary parameters after the intervention period. Furthermore, all measured outcome variables in the safety assessment were not significant, with values remaining stable during the intervention period for participants in both groups. This is the first study to document the effects and the safety profile of higenamine-based dietary supplements at a specified dose in female recreational athletes. Our data indicate that 21-day of supplementation with 75 mg higenamine would not result in improving cardiopulmonary exercise fitness and weight loss in female recreational athletes. Moreover, supplementation with 75 mg higenamine is safe and well-tolerated in younger recreational female athletes.",
publisher = "Frontiers Media S.A.",
journal = "Frontiers in Psychology",
title = "Influence of Higenamine on Exercise Performance of Recreational Female Athletes: A Randomized Double-Blinded Placebo-Controlled Trial",
pages = "633110",
volume = "12",
doi = "10.3389/fpsyg.2021.633110"
}

Rašić, J. S., Ivanović, N., Anđelković, M. S., Nedeljković, I. P., Nikolic, I. R., Stojanović, S. D., Ristić-Medić, D., Takić, M., Đorđević, B. I.,& Dikić, N. V.. (2021). Influence of Higenamine on Exercise Performance of Recreational Female Athletes: A Randomized Double-Blinded Placebo-Controlled Trial. in Frontiers in Psychology
Frontiers Media S.A.., 12, 633110.
https://doi.org/10.3389/fpsyg.2021.633110

Rašić JS, Ivanović N, Anđelković MS, Nedeljković IP, Nikolic IR, Stojanović SD, Ristić-Medić D, Takić M, Đorđević BI, Dikić NV. Influence of Higenamine on Exercise Performance of Recreational Female Athletes: A Randomized Double-Blinded Placebo-Controlled Trial. in Frontiers in Psychology. 2021;12:633110.
doi:10.3389/fpsyg.2021.633110 .

Rašić, Jelena S., Ivanović, Nevena, Anđelković, Marija S., Nedeljković, Ivana P., Nikolic, Ivan R., Stojanović, Sava D., Ristić-Medić, Danijela, Takić, Marija, Đorđević, Brizita I., Dikić, Nenad V., "Influence of Higenamine on Exercise Performance of Recreational Female Athletes: A Randomized Double-Blinded Placebo-Controlled Trial" in Frontiers in Psychology, 12 (2021):633110,
https://doi.org/10.3389/fpsyg.2021.633110 . .

TY  - CONF
AU  - Krga, Irena
AU  - Zec, Manja
AU  - Takić, Marija
AU  - Debeljak-Martačić, Jasmina
AU  - Korićanac, Goran
AU  - Ranković, Slavica
AU  - Popović, Tamara
AU  - Glibetić, Marija
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1384
PB  - Belgrade : University of Belgrade
C3  - UniFood conference, 2nd International UniFood Conference Belgrade, 24 - 25 September 2021 - Book of Abstracts
T1  - Walnuts consumption modulates endigenous metabolic conversion towards long-chain fatty acids and effects individual fatty acid content in plasma and liver of fructose-fed rats
UR  - https://hdl.handle.net/21.15107/rcub_rimi_1384
ER  - 

@conference{
author = "Krga, Irena and Zec, Manja and Takić, Marija and Debeljak-Martačić, Jasmina and Korićanac, Goran and Ranković, Slavica and Popović, Tamara and Glibetić, Marija",
year = "2021",
publisher = "Belgrade : University of Belgrade",
journal = "UniFood conference, 2nd International UniFood Conference Belgrade, 24 - 25 September 2021 - Book of Abstracts",
title = "Walnuts consumption modulates endigenous metabolic conversion towards long-chain fatty acids and effects individual fatty acid content in plasma and liver of fructose-fed rats",
url = "https://hdl.handle.net/21.15107/rcub_rimi_1384"
}

Krga, I., Zec, M., Takić, M., Debeljak-Martačić, J., Korićanac, G., Ranković, S., Popović, T.,& Glibetić, M.. (2021). Walnuts consumption modulates endigenous metabolic conversion towards long-chain fatty acids and effects individual fatty acid content in plasma and liver of fructose-fed rats. in UniFood conference, 2nd International UniFood Conference Belgrade, 24 - 25 September 2021 - Book of Abstracts
Belgrade : University of Belgrade..
https://hdl.handle.net/21.15107/rcub_rimi_1384

Krga I, Zec M, Takić M, Debeljak-Martačić J, Korićanac G, Ranković S, Popović T, Glibetić M. Walnuts consumption modulates endigenous metabolic conversion towards long-chain fatty acids and effects individual fatty acid content in plasma and liver of fructose-fed rats. in UniFood conference, 2nd International UniFood Conference Belgrade, 24 - 25 September 2021 - Book of Abstracts. 2021;.
https://hdl.handle.net/21.15107/rcub_rimi_1384 .

Krga, Irena, Zec, Manja, Takić, Marija, Debeljak-Martačić, Jasmina, Korićanac, Goran, Ranković, Slavica, Popović, Tamara, Glibetić, Marija, "Walnuts consumption modulates endigenous metabolic conversion towards long-chain fatty acids and effects individual fatty acid content in plasma and liver of fructose-fed rats" in UniFood conference, 2nd International UniFood Conference Belgrade, 24 - 25 September 2021 - Book of Abstracts (2021),
https://hdl.handle.net/21.15107/rcub_rimi_1384 .

TY  - JOUR
AU  - Takić, Marija
AU  - Zeković, Milica
AU  - Terzić, Brankica
AU  - Stojsavljević, Aleksandar
AU  - Mijušković, Mirjana
AU  - Rađen, Slavica
AU  - Ristić-Medić, Danijela
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1200
AB  - Background: Desaturation and elongation are critical processes in endogenous metabolic fatty acid pathways. Zinc (Zn) is a cofactor for desaturases and elongases enzymes. There is limited evidence regarding the relationships between biomarkers of Zn status, nutritional intake, plasma phospholipid fatty acid profile and clinical outcomes among patients undergoing hemodialysis (HD).  Objective: To examine the relationships between dietary and serum levels of Zn and Cu/Zn ratio and to explore associations of these micronutrients with PUFA profile and estimated desaturase and elongase enzyme activities in serum phospholipids among HD patients.  Methods: This study included 40 adult patients undergoing hemodialysis treatment. Repeated 24-h recalls were applied for dietary intake assessment. Serum concentration of Zn and Cu were determined using inductively coupled plasma mass spectrometry and fatty acid composition by gas-liquid chromatography. Desaturase and elongase activities were calculated from product-precursor fatty acid ratios.  Results: Inadequate dietary Zn intake was found in 55% of HD patients. They all had serum Zn concentration below the reference value of 60 μg/dL (mean 38.8 ± 7.72 μg/dL). Adequate zinc intake was accompanied with significantly higher intake of energy, total fats, SFA, MUFA and proteins. There was no correlation between Zn serum status and Zn intake estimates. Serum Cu/Zn ratio was high, (2.76 ± 0.68), directly and significantly associated with HD period, CRP, BMI, VFA, and inversely with Kt/V, albumin, iron, and iPTH. The n-6/n-3 ratio in plasma phospholipids was elevated (12.25 ± 3.45) and patients with inadequate Zn intake had lower n-3 PUFA intake and status compared to those with adequate intake. Serum Zn concentrations were inversely correlated with linoleic/dihomo-γ-linolenic acid ratio (LA/DGLA) (p = 0.037), related to D6-desaturase activity (p = 0.033) and directly with DGLA relative abundances (p = 0.024). Cu status was inversely associated with EPA level (p = 0.03) and estimates of elongase activity (p = 0.001). Furthermore, positive relationship was found between the Cu/Zn ratio and determined elongase value (p = 0.01).  Conclusion: Findings of this study underpin the high prevalence of Zn deficiency and inadequate n-3 PUFA intake and status among subjects undergoing HD. The results obtained indicate that the assessment of Zn status should be a standard parameter of nutritional status screening in HD patients while emphasizing the importance of Cu/Zn determination. Although further research is warranted, Zn and-n-3 PUFA supplementation in HD patients might be beneficial for the prevention and attenuation of adverse health outcomes.
PB  - Frontiers Media S.A.
T2  - Frontiers in Nutrition
T1  - Zinc Deficiency, Plasma Fatty Acid Profile and Desaturase Activities in Hemodialysis Patients: Is Supplementation Necessary?
SP  - 700450
VL  - 8
UR  - https://hdl.handle.net/21.15107/rcub_rimi_1200
ER  - 

@article{
author = "Takić, Marija and Zeković, Milica and Terzić, Brankica and Stojsavljević, Aleksandar and Mijušković, Mirjana and Rađen, Slavica and Ristić-Medić, Danijela",
year = "2021",
abstract = "Background: Desaturation and elongation are critical processes in endogenous metabolic fatty acid pathways. Zinc (Zn) is a cofactor for desaturases and elongases enzymes. There is limited evidence regarding the relationships between biomarkers of Zn status, nutritional intake, plasma phospholipid fatty acid profile and clinical outcomes among patients undergoing hemodialysis (HD).  Objective: To examine the relationships between dietary and serum levels of Zn and Cu/Zn ratio and to explore associations of these micronutrients with PUFA profile and estimated desaturase and elongase enzyme activities in serum phospholipids among HD patients.  Methods: This study included 40 adult patients undergoing hemodialysis treatment. Repeated 24-h recalls were applied for dietary intake assessment. Serum concentration of Zn and Cu were determined using inductively coupled plasma mass spectrometry and fatty acid composition by gas-liquid chromatography. Desaturase and elongase activities were calculated from product-precursor fatty acid ratios.  Results: Inadequate dietary Zn intake was found in 55% of HD patients. They all had serum Zn concentration below the reference value of 60 μg/dL (mean 38.8 ± 7.72 μg/dL). Adequate zinc intake was accompanied with significantly higher intake of energy, total fats, SFA, MUFA and proteins. There was no correlation between Zn serum status and Zn intake estimates. Serum Cu/Zn ratio was high, (2.76 ± 0.68), directly and significantly associated with HD period, CRP, BMI, VFA, and inversely with Kt/V, albumin, iron, and iPTH. The n-6/n-3 ratio in plasma phospholipids was elevated (12.25 ± 3.45) and patients with inadequate Zn intake had lower n-3 PUFA intake and status compared to those with adequate intake. Serum Zn concentrations were inversely correlated with linoleic/dihomo-γ-linolenic acid ratio (LA/DGLA) (p = 0.037), related to D6-desaturase activity (p = 0.033) and directly with DGLA relative abundances (p = 0.024). Cu status was inversely associated with EPA level (p = 0.03) and estimates of elongase activity (p = 0.001). Furthermore, positive relationship was found between the Cu/Zn ratio and determined elongase value (p = 0.01).  Conclusion: Findings of this study underpin the high prevalence of Zn deficiency and inadequate n-3 PUFA intake and status among subjects undergoing HD. The results obtained indicate that the assessment of Zn status should be a standard parameter of nutritional status screening in HD patients while emphasizing the importance of Cu/Zn determination. Although further research is warranted, Zn and-n-3 PUFA supplementation in HD patients might be beneficial for the prevention and attenuation of adverse health outcomes.",
publisher = "Frontiers Media S.A.",
journal = "Frontiers in Nutrition",
title = "Zinc Deficiency, Plasma Fatty Acid Profile and Desaturase Activities in Hemodialysis Patients: Is Supplementation Necessary?",
pages = "700450",
volume = "8",
url = "https://hdl.handle.net/21.15107/rcub_rimi_1200"
}

Takić, M., Zeković, M., Terzić, B., Stojsavljević, A., Mijušković, M., Rađen, S.,& Ristić-Medić, D.. (2021). Zinc Deficiency, Plasma Fatty Acid Profile and Desaturase Activities in Hemodialysis Patients: Is Supplementation Necessary?. in Frontiers in Nutrition
Frontiers Media S.A.., 8, 700450.
https://hdl.handle.net/21.15107/rcub_rimi_1200

Takić M, Zeković M, Terzić B, Stojsavljević A, Mijušković M, Rađen S, Ristić-Medić D. Zinc Deficiency, Plasma Fatty Acid Profile and Desaturase Activities in Hemodialysis Patients: Is Supplementation Necessary?. in Frontiers in Nutrition. 2021;8:700450.
https://hdl.handle.net/21.15107/rcub_rimi_1200 .

Takić, Marija, Zeković, Milica, Terzić, Brankica, Stojsavljević, Aleksandar, Mijušković, Mirjana, Rađen, Slavica, Ristić-Medić, Danijela, "Zinc Deficiency, Plasma Fatty Acid Profile and Desaturase Activities in Hemodialysis Patients: Is Supplementation Necessary?" in Frontiers in Nutrition, 8 (2021):700450,
https://hdl.handle.net/21.15107/rcub_rimi_1200 .

TY  - JOUR
AU  - Dakić, Tamara
AU  - Lakić, Iva
AU  - Zec, Manja
AU  - Takić, Marija
AU  - Stojiljković, Mojca
AU  - Jevđović, Tanja
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1197
AB  - BACKGROUND: Nutritional modulations may be considered a strategy to protect mental health. Neuronal homeostasis is highly dependent on the availability of glucose, which represents the primary energy source for the brain. In this study, we evaluated the effects of walnut intake and fructose-rich diet on the expression of glucose transporters (GLUTs) in two rat brain regions: hypothalamus and hippocampus. RESULTS: Our results show that walnut supplementation of fructose-fed animals restored the hypothalamic content of GLUT1 and GLUT3 protein. Furthermore, walnut intake did not affect increased hypothalamic GLUT2 content upon fructose consumption. These effects were accompanied by distinctive alterations of hippocampal GLUTs levels. Specifically, walnut intake increased GLUT1 content, whereas GLUT2 protein was decreased within the rat hippocampus after both individual and combined treatments. CONCLUSION: Overall, our study suggests that walnut supplementation exerted modulatory effects on the glucose transporters within specific brain regions in the presence of developed metabolic disorder.
PB  - Wiley
T2  - Journal of the Science of Food and Agriculture
T1  - Fructose-rich diet and walnut supplementation differently regulate rat hypothalamic and hippocampal glucose transporters expression
EP  - 5991
IS  - 14
SP  - 5984
VL  - 101
DO  - 10.1002/jsfa.11252
ER  - 

@article{
author = "Dakić, Tamara and Lakić, Iva and Zec, Manja and Takić, Marija and Stojiljković, Mojca and Jevđović, Tanja",
year = "2021",
abstract = "BACKGROUND: Nutritional modulations may be considered a strategy to protect mental health. Neuronal homeostasis is highly dependent on the availability of glucose, which represents the primary energy source for the brain. In this study, we evaluated the effects of walnut intake and fructose-rich diet on the expression of glucose transporters (GLUTs) in two rat brain regions: hypothalamus and hippocampus. RESULTS: Our results show that walnut supplementation of fructose-fed animals restored the hypothalamic content of GLUT1 and GLUT3 protein. Furthermore, walnut intake did not affect increased hypothalamic GLUT2 content upon fructose consumption. These effects were accompanied by distinctive alterations of hippocampal GLUTs levels. Specifically, walnut intake increased GLUT1 content, whereas GLUT2 protein was decreased within the rat hippocampus after both individual and combined treatments. CONCLUSION: Overall, our study suggests that walnut supplementation exerted modulatory effects on the glucose transporters within specific brain regions in the presence of developed metabolic disorder.",
publisher = "Wiley",
journal = "Journal of the Science of Food and Agriculture",
title = "Fructose-rich diet and walnut supplementation differently regulate rat hypothalamic and hippocampal glucose transporters expression",
pages = "5991-5984",
number = "14",
volume = "101",
doi = "10.1002/jsfa.11252"
}

Dakić, T., Lakić, I., Zec, M., Takić, M., Stojiljković, M.,& Jevđović, T.. (2021). Fructose-rich diet and walnut supplementation differently regulate rat hypothalamic and hippocampal glucose transporters expression. in Journal of the Science of Food and Agriculture
Wiley., 101(14), 5984-5991.
https://doi.org/10.1002/jsfa.11252

Dakić T, Lakić I, Zec M, Takić M, Stojiljković M, Jevđović T. Fructose-rich diet and walnut supplementation differently regulate rat hypothalamic and hippocampal glucose transporters expression. in Journal of the Science of Food and Agriculture. 2021;101(14):5984-5991.
doi:10.1002/jsfa.11252 .

Dakić, Tamara, Lakić, Iva, Zec, Manja, Takić, Marija, Stojiljković, Mojca, Jevđović, Tanja, "Fructose-rich diet and walnut supplementation differently regulate rat hypothalamic and hippocampal glucose transporters expression" in Journal of the Science of Food and Agriculture, 101, no. 14 (2021):5984-5991,
https://doi.org/10.1002/jsfa.11252 . .

TY  - JOUR
AU  - Zec, Manja M.
AU  - Krga, Irena
AU  - Takić, Marija
AU  - Debeljak-Martačić, Jasmina
AU  - Korićanac, Goran
AU  - Ranković, Slavica G.
AU  - Popović, Tamara B.
AU  - Pantelić, Marija
AU  - Glibetić, Marija
PY  - 2020
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/984
AB  - Increased dietary, blood, and tissue n-6/n-3 fatty acid ratios are associated with obesity and metabolic syndrome. Due to Westernized dietary patterns, the increasing n-6/n-3 ratio is of growing concern worldwide, and dietary strategies aimed at its lowering are of public health importance. Walnuts are rich in dietary fats, and their consumption promotes cardiometabolic health. This study aimed to examine the effect of 6-week walnut consumption on tissue-specific n-6/n-3 ratio and fatty acid metabolic conversion in fructose-fed rats with a cluster of metabolic disorders. Male Wistar rats were fed a standard diet with or without 10% fructose in drinking water for 9 weeks. Diets of half of the animals were then supplemented with walnuts (2.4 g/day) for 6 weeks, upon which fatty acid profiles were determined in plasma, liver, adipose tissue, and kidney total lipids. Results showed that walnuts induced significant decreases in the n-6/n-3 content of total lipid pool in plasma and examined tissues, irrespective of metabolic burden. Walnut intervention decreased plasma and liver palmitoleic/palmitic, arachidonic/linoleic, and docosahexaenoic/alpha-linolenic acid ratios. It also modulated individual fatty acid levels by reducing arachidonic and palmitic acid and increasing alpha-linolenic, eicosapentaenoic, and docosapentaenoic acid in plasma and most tissues. Our study demonstrated that 6-week consumption of walnuts favorably modulated n-6/n-3 plasma and tissue ratio in male Wistar rats regardless of high-fructose feeding, underscoring the promising potential of walnuts in both prevention and treatment of the metabolic syndrome.
PB  - Amer Chemical Soc, Washington
T2  - ACS Omega
T1  - Walnut Consumption Induces Tissue-Specific Omega-6/Omega-3 Decrease in High-Fructose-Fed Wistar Rats
EP  - 28145
IS  - 43
SP  - 28136
VL  - 5
DO  - 10.1021/acsomega.0c03784
ER  - 

@article{
author = "Zec, Manja M. and Krga, Irena and Takić, Marija and Debeljak-Martačić, Jasmina and Korićanac, Goran and Ranković, Slavica G. and Popović, Tamara B. and Pantelić, Marija and Glibetić, Marija",
year = "2020",
abstract = "Increased dietary, blood, and tissue n-6/n-3 fatty acid ratios are associated with obesity and metabolic syndrome. Due to Westernized dietary patterns, the increasing n-6/n-3 ratio is of growing concern worldwide, and dietary strategies aimed at its lowering are of public health importance. Walnuts are rich in dietary fats, and their consumption promotes cardiometabolic health. This study aimed to examine the effect of 6-week walnut consumption on tissue-specific n-6/n-3 ratio and fatty acid metabolic conversion in fructose-fed rats with a cluster of metabolic disorders. Male Wistar rats were fed a standard diet with or without 10% fructose in drinking water for 9 weeks. Diets of half of the animals were then supplemented with walnuts (2.4 g/day) for 6 weeks, upon which fatty acid profiles were determined in plasma, liver, adipose tissue, and kidney total lipids. Results showed that walnuts induced significant decreases in the n-6/n-3 content of total lipid pool in plasma and examined tissues, irrespective of metabolic burden. Walnut intervention decreased plasma and liver palmitoleic/palmitic, arachidonic/linoleic, and docosahexaenoic/alpha-linolenic acid ratios. It also modulated individual fatty acid levels by reducing arachidonic and palmitic acid and increasing alpha-linolenic, eicosapentaenoic, and docosapentaenoic acid in plasma and most tissues. Our study demonstrated that 6-week consumption of walnuts favorably modulated n-6/n-3 plasma and tissue ratio in male Wistar rats regardless of high-fructose feeding, underscoring the promising potential of walnuts in both prevention and treatment of the metabolic syndrome.",
publisher = "Amer Chemical Soc, Washington",
journal = "ACS Omega",
title = "Walnut Consumption Induces Tissue-Specific Omega-6/Omega-3 Decrease in High-Fructose-Fed Wistar Rats",
pages = "28145-28136",
number = "43",
volume = "5",
doi = "10.1021/acsomega.0c03784"
}

Zec, M. M., Krga, I., Takić, M., Debeljak-Martačić, J., Korićanac, G., Ranković, S. G., Popović, T. B., Pantelić, M.,& Glibetić, M.. (2020). Walnut Consumption Induces Tissue-Specific Omega-6/Omega-3 Decrease in High-Fructose-Fed Wistar Rats. in ACS Omega
Amer Chemical Soc, Washington., 5(43), 28136-28145.
https://doi.org/10.1021/acsomega.0c03784

Zec MM, Krga I, Takić M, Debeljak-Martačić J, Korićanac G, Ranković SG, Popović TB, Pantelić M, Glibetić M. Walnut Consumption Induces Tissue-Specific Omega-6/Omega-3 Decrease in High-Fructose-Fed Wistar Rats. in ACS Omega. 2020;5(43):28136-28145.
doi:10.1021/acsomega.0c03784 .

Zec, Manja M., Krga, Irena, Takić, Marija, Debeljak-Martačić, Jasmina, Korićanac, Goran, Ranković, Slavica G., Popović, Tamara B., Pantelić, Marija, Glibetić, Marija, "Walnut Consumption Induces Tissue-Specific Omega-6/Omega-3 Decrease in High-Fructose-Fed Wistar Rats" in ACS Omega, 5, no. 43 (2020):28136-28145,
https://doi.org/10.1021/acsomega.0c03784 . .

TY  - JOUR
AU  - Popović, Tamara B.
AU  - Debeljak-Martačić, Jasmina
AU  - Petrović-Oggiano, Gordana P.
AU  - Glibetić, Marija
AU  - Kojadinović, Milica
AU  - Takić, Marija
PY  - 2019
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/945
AB  - Background: Walnuts consumption produces beneficial effects on human health. Health-promoting benefits are dedicated to its desirable fatty acid profile and high content of antioxidants. Heat treatment of walnuts may alter their fatty acid composition and antioxidant capacity. Aim: In general the aim of this work was to compare fatty acids profiles and antioxidative properties of raw and dried walnuts at 60 °C for 12 hours. Methodology and results: FA profiles were analyzed using gas chromatography. Antioxidative capacities of walnut samples were determined by DPPH and ABTS tests. There were no significant differences in fatty acid profiles comparing dried and raw walnuts. The most abundant fatty acid was linoleic with mean content of 61.38 ± 1.11% in raw and 62.40 ± 0.99% in dried walnuts. Walnuts oil contained 10.64 ± 0.46% and 10.49 ± 0.81% of a-linolenic acid (ALA) in raw and dried walnuts, respectively. Antioxidative capacity of methanolic extracts showed no difference comparing raw and dried walnut by DPPH and ABTS test. Heat treatment at 60 °C for 12h induced no change in fatty acid profiles of walnuts and led to minor decrease in antioxidative capacity measured only by ABTS test. Conclusion: We suggest that drying process in our experiment did not decreased nutritional capacity which is mostly mediated by conservation of fatty acids content in walnuts.
AB  - Dijetarni unos oraha povezuje se sa brojnim pozitivnim efektima na zdravlje. Svoj efekat na zdravlje orasi ostvaruju zahvaljujući povoljnom masnokiselinskom sastavu i visokom sadržaju antioksidanasa. Zagrevanje oraha moglo bi dovesti do promena u masnokiselinskom sastavu i uticati na antioksidativni kapacitet. Cilj ovog rada bio je da se uporede masnokiselinski profili i antioksidativni status svežih i oraha sušenih na 60 °C u trajanju od 12 sati. Masnokiselinski sastav analiziran je gasnom hromatografijom. Antioksidativni kapaciteti uzoraka oraha odreðivani su DPPH i ABTS testovima. Utvrðeno je da nije bilo promena u masnokiselinskim profilima posle sušenja oraha na 60 °C u trajanju od 12 sati. Najzastupljenija masna kiselina bila je linolna sa sadržajem od 61.38 ± 1.11% u sirovim i 62.40 ± 0.99% kod sušenih oraha. Ulje oraha sadržalo je 10.64 ± 0.46% i 10.49 ± 0.81% a-linolenske kiseline (ALA) u svežim i sušenim orasima, respektivno. DPPH testom nije utvrđeno da postoje razlike u antioksidativnom potencijalu metanolnih ekstrakata oraha sušenih u odnosu na sveže kao ni sa ABTS testom. Naš eksperimet je pokazao da proces sušenja oraha nije smanjio njihov nutritivni kapacitet što je verovatno posredovano očuvanjem sadržaja masnih kiselina.
PB  - Društvo za ishranu Srbije, Beograd
T2  - Hrana i ishrana
T1  - Fatty acid profiles and antioxidant properties of raw and dried walnuts
T1  - Profili masnih kiselina i antioksidativna svojstva sirovih i sušenih oraha
EP  - 58
IS  - 2
SP  - 55
VL  - 60
DO  - 10.5937/hraIsh1902055P
ER  - 

@article{
author = "Popović, Tamara B. and Debeljak-Martačić, Jasmina and Petrović-Oggiano, Gordana P. and Glibetić, Marija and Kojadinović, Milica and Takić, Marija",
year = "2019",
abstract = "Background: Walnuts consumption produces beneficial effects on human health. Health-promoting benefits are dedicated to its desirable fatty acid profile and high content of antioxidants. Heat treatment of walnuts may alter their fatty acid composition and antioxidant capacity. Aim: In general the aim of this work was to compare fatty acids profiles and antioxidative properties of raw and dried walnuts at 60 °C for 12 hours. Methodology and results: FA profiles were analyzed using gas chromatography. Antioxidative capacities of walnut samples were determined by DPPH and ABTS tests. There were no significant differences in fatty acid profiles comparing dried and raw walnuts. The most abundant fatty acid was linoleic with mean content of 61.38 ± 1.11% in raw and 62.40 ± 0.99% in dried walnuts. Walnuts oil contained 10.64 ± 0.46% and 10.49 ± 0.81% of a-linolenic acid (ALA) in raw and dried walnuts, respectively. Antioxidative capacity of methanolic extracts showed no difference comparing raw and dried walnut by DPPH and ABTS test. Heat treatment at 60 °C for 12h induced no change in fatty acid profiles of walnuts and led to minor decrease in antioxidative capacity measured only by ABTS test. Conclusion: We suggest that drying process in our experiment did not decreased nutritional capacity which is mostly mediated by conservation of fatty acids content in walnuts., Dijetarni unos oraha povezuje se sa brojnim pozitivnim efektima na zdravlje. Svoj efekat na zdravlje orasi ostvaruju zahvaljujući povoljnom masnokiselinskom sastavu i visokom sadržaju antioksidanasa. Zagrevanje oraha moglo bi dovesti do promena u masnokiselinskom sastavu i uticati na antioksidativni kapacitet. Cilj ovog rada bio je da se uporede masnokiselinski profili i antioksidativni status svežih i oraha sušenih na 60 °C u trajanju od 12 sati. Masnokiselinski sastav analiziran je gasnom hromatografijom. Antioksidativni kapaciteti uzoraka oraha odreðivani su DPPH i ABTS testovima. Utvrðeno je da nije bilo promena u masnokiselinskim profilima posle sušenja oraha na 60 °C u trajanju od 12 sati. Najzastupljenija masna kiselina bila je linolna sa sadržajem od 61.38 ± 1.11% u sirovim i 62.40 ± 0.99% kod sušenih oraha. Ulje oraha sadržalo je 10.64 ± 0.46% i 10.49 ± 0.81% a-linolenske kiseline (ALA) u svežim i sušenim orasima, respektivno. DPPH testom nije utvrđeno da postoje razlike u antioksidativnom potencijalu metanolnih ekstrakata oraha sušenih u odnosu na sveže kao ni sa ABTS testom. Naš eksperimet je pokazao da proces sušenja oraha nije smanjio njihov nutritivni kapacitet što je verovatno posredovano očuvanjem sadržaja masnih kiselina.",
publisher = "Društvo za ishranu Srbije, Beograd",
journal = "Hrana i ishrana",
title = "Fatty acid profiles and antioxidant properties of raw and dried walnuts, Profili masnih kiselina i antioksidativna svojstva sirovih i sušenih oraha",
pages = "58-55",
number = "2",
volume = "60",
doi = "10.5937/hraIsh1902055P"
}

Popović, T. B., Debeljak-Martačić, J., Petrović-Oggiano, G. P., Glibetić, M., Kojadinović, M.,& Takić, M.. (2019). Fatty acid profiles and antioxidant properties of raw and dried walnuts. in Hrana i ishrana
Društvo za ishranu Srbije, Beograd., 60(2), 55-58.
https://doi.org/10.5937/hraIsh1902055P

Popović TB, Debeljak-Martačić J, Petrović-Oggiano GP, Glibetić M, Kojadinović M, Takić M. Fatty acid profiles and antioxidant properties of raw and dried walnuts. in Hrana i ishrana. 2019;60(2):55-58.
doi:10.5937/hraIsh1902055P .

Popović, Tamara B., Debeljak-Martačić, Jasmina, Petrović-Oggiano, Gordana P., Glibetić, Marija, Kojadinović, Milica, Takić, Marija, "Fatty acid profiles and antioxidant properties of raw and dried walnuts" in Hrana i ishrana, 60, no. 2 (2019):55-58,
https://doi.org/10.5937/hraIsh1902055P . .

TY  - JOUR
AU  - Penezić, Ana Z.
AU  - Aćimović, Jelena M.
AU  - Pavićević, Ivan D.
AU  - Jovanović, Vesna B.
AU  - Takić, Marija
AU  - Mandić, Ljuba M.
PY  - 2019
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/946
AB  - Cys34 thiol group of human serum albumin (HSA) represents major plasma antioxidant. Its reactivity is influenced by multiple factors. The influence of fatty acids (FA; saturated, mono, and poly unsaturated acids from fish oil) binding to HSA, on copper(II) binding affinity and Cys34 thiol group accessibility/reactivity, in the presence of carbonylation agent (methylglyoxal, MG) was examined. HSA-copper(II) content, thiol group reactivity, and HSA carbonylation level were monitored spectrophotometrically. Changes in HSA were followed by fluorescence spectroscopy and native PAG electrophoresis. FA/HSA molar ratio was screened by GC. Together, binding of copper(II) ions and FA to HSA increase the reactivity of Cys34 thiol group (depending on the type of FA), with constant contribution of copper(II) ions of one-third. Carbonylation of FA-HSA-Cu(II) complexes caused a decrease in the Cys34 thiol group content, accompanied by a decrease in the content of HSA-bound copper. The carbonylation level of guanidine groups was not affected by FAs and copper(II) binding. Fluorescent emission spectra of FA-HSA-Cu(II)-MG complexes showed conformational changes in HSA molecule. Although binding of fatty acids and copper ions caused a significant increase in the thiol group reactivity, Cys34 thiol from FA-HSA-Cu(II) complexes reacted with MG in smaller extent than expected, probably as a consequence of conformational changes introduced by carbonylation. Increase in the percentage of reacted-free thiol groups with MG (due to FA and copper binding) may not seem to be very significant, but it is very important in complex biological systems, where catalytic metal is present. [GRAPHICS] .
PB  - Springer, New York
T2  - Journal of Biological Inorganic Chemistry
T1  - The interplay between copper(II), human serum albumin, fatty acids, and carbonylating agent interferes with Cys 34 thiol reactivity and copper binding
EP  - 70
IS  - 1
SP  - 61
VL  - 24
DO  - 10.1007/s00775-018-1628-7
ER  - 

@article{
author = "Penezić, Ana Z. and Aćimović, Jelena M. and Pavićević, Ivan D. and Jovanović, Vesna B. and Takić, Marija and Mandić, Ljuba M.",
year = "2019",
abstract = "Cys34 thiol group of human serum albumin (HSA) represents major plasma antioxidant. Its reactivity is influenced by multiple factors. The influence of fatty acids (FA; saturated, mono, and poly unsaturated acids from fish oil) binding to HSA, on copper(II) binding affinity and Cys34 thiol group accessibility/reactivity, in the presence of carbonylation agent (methylglyoxal, MG) was examined. HSA-copper(II) content, thiol group reactivity, and HSA carbonylation level were monitored spectrophotometrically. Changes in HSA were followed by fluorescence spectroscopy and native PAG electrophoresis. FA/HSA molar ratio was screened by GC. Together, binding of copper(II) ions and FA to HSA increase the reactivity of Cys34 thiol group (depending on the type of FA), with constant contribution of copper(II) ions of one-third. Carbonylation of FA-HSA-Cu(II) complexes caused a decrease in the Cys34 thiol group content, accompanied by a decrease in the content of HSA-bound copper. The carbonylation level of guanidine groups was not affected by FAs and copper(II) binding. Fluorescent emission spectra of FA-HSA-Cu(II)-MG complexes showed conformational changes in HSA molecule. Although binding of fatty acids and copper ions caused a significant increase in the thiol group reactivity, Cys34 thiol from FA-HSA-Cu(II) complexes reacted with MG in smaller extent than expected, probably as a consequence of conformational changes introduced by carbonylation. Increase in the percentage of reacted-free thiol groups with MG (due to FA and copper binding) may not seem to be very significant, but it is very important in complex biological systems, where catalytic metal is present. [GRAPHICS] .",
publisher = "Springer, New York",
journal = "Journal of Biological Inorganic Chemistry",
title = "The interplay between copper(II), human serum albumin, fatty acids, and carbonylating agent interferes with Cys 34 thiol reactivity and copper binding",
pages = "70-61",
number = "1",
volume = "24",
doi = "10.1007/s00775-018-1628-7"
}

Penezić, A. Z., Aćimović, J. M., Pavićević, I. D., Jovanović, V. B., Takić, M.,& Mandić, L. M.. (2019). The interplay between copper(II), human serum albumin, fatty acids, and carbonylating agent interferes with Cys 34 thiol reactivity and copper binding. in Journal of Biological Inorganic Chemistry
Springer, New York., 24(1), 61-70.
https://doi.org/10.1007/s00775-018-1628-7

Penezić AZ, Aćimović JM, Pavićević ID, Jovanović VB, Takić M, Mandić LM. The interplay between copper(II), human serum albumin, fatty acids, and carbonylating agent interferes with Cys 34 thiol reactivity and copper binding. in Journal of Biological Inorganic Chemistry. 2019;24(1):61-70.
doi:10.1007/s00775-018-1628-7 .

Penezić, Ana Z., Aćimović, Jelena M., Pavićević, Ivan D., Jovanović, Vesna B., Takić, Marija, Mandić, Ljuba M., "The interplay between copper(II), human serum albumin, fatty acids, and carbonylating agent interferes with Cys 34 thiol reactivity and copper binding" in Journal of Biological Inorganic Chemistry, 24, no. 1 (2019):61-70,
https://doi.org/10.1007/s00775-018-1628-7 . .

TY  - JOUR
AU  - Martačić, Jasmina
AU  - Kovačević-Filipović, Milica
AU  - Borozan, Sunčica
AU  - Cvetković, Zorica
AU  - Popović, Tamara B.
AU  - Arsić, Aleksandra
AU  - Takić, Marija
AU  - Vučić, Vesna M.
AU  - Glibetić, Marija
PY  - 2018
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/866
AB  - Objectives The aim of our study was to investigate whether N-acetyl-L-cysteine (NAC) could protect stem cells from exfoliated deciduous teeth (SHED) against oxidative damage, during in vitro cultivation, to preserve regenerative potential of these cells. Accordingly, we examined the potential of cell culture supplementation with NAC in prevention of lipid peroxidation, unfavorable changes of total lipids fatty acid composition, and the effects on the activity of antioxidant enzymes. Material and methods We analyzed the extent of oxidative damage in SHED after 48 h treatment with different NAC concentrations. Cellular lipid peroxidation was determined upon reaction with thiobarbituric acid. All enzyme activities were measured spectrophotometrically, based on published methods. Fatty acid methyl esters were analyzed by gas-liquid chromatography. Results Concentration of 0.1 mM NAC showed the most profound effects on SHED, significantly decreasing levels of lipid peroxidation in comparison to control. This dose also diminished the activities of antioxidant enzymes. Furthermore, NAC treatment significantly changed fatty acid composition of cells, reducing levels of oleic acid and monounsaturated fatty acids and increasing linoleic acid, n-6, and total polyunsaturated fatty acid (PUFA) proportions. Conclusion Low dose of NAC significantly decreased lipid peroxidation and altered fatty acid composition towards increasing PUFA. The reduced oxidative damage of cellular lipids could be strongly related to improved SHED survival in vitro.
PB  - Springer Heidelberg, Heidelberg
T2  - Clinical Oral Investigations
T1  - N-acetyl-L-cysteine protects dental tissue stem cells against oxidative stress in vitro
EP  - 2903
IS  - 8
SP  - 2897
VL  - 22
DO  - 10.1007/s00784-018-2377-2
ER  - 

@article{
author = "Martačić, Jasmina and Kovačević-Filipović, Milica and Borozan, Sunčica and Cvetković, Zorica and Popović, Tamara B. and Arsić, Aleksandra and Takić, Marija and Vučić, Vesna M. and Glibetić, Marija",
year = "2018",
abstract = "Objectives The aim of our study was to investigate whether N-acetyl-L-cysteine (NAC) could protect stem cells from exfoliated deciduous teeth (SHED) against oxidative damage, during in vitro cultivation, to preserve regenerative potential of these cells. Accordingly, we examined the potential of cell culture supplementation with NAC in prevention of lipid peroxidation, unfavorable changes of total lipids fatty acid composition, and the effects on the activity of antioxidant enzymes. Material and methods We analyzed the extent of oxidative damage in SHED after 48 h treatment with different NAC concentrations. Cellular lipid peroxidation was determined upon reaction with thiobarbituric acid. All enzyme activities were measured spectrophotometrically, based on published methods. Fatty acid methyl esters were analyzed by gas-liquid chromatography. Results Concentration of 0.1 mM NAC showed the most profound effects on SHED, significantly decreasing levels of lipid peroxidation in comparison to control. This dose also diminished the activities of antioxidant enzymes. Furthermore, NAC treatment significantly changed fatty acid composition of cells, reducing levels of oleic acid and monounsaturated fatty acids and increasing linoleic acid, n-6, and total polyunsaturated fatty acid (PUFA) proportions. Conclusion Low dose of NAC significantly decreased lipid peroxidation and altered fatty acid composition towards increasing PUFA. The reduced oxidative damage of cellular lipids could be strongly related to improved SHED survival in vitro.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Clinical Oral Investigations",
title = "N-acetyl-L-cysteine protects dental tissue stem cells against oxidative stress in vitro",
pages = "2903-2897",
number = "8",
volume = "22",
doi = "10.1007/s00784-018-2377-2"
}

Martačić, J., Kovačević-Filipović, M., Borozan, S., Cvetković, Z., Popović, T. B., Arsić, A., Takić, M., Vučić, V. M.,& Glibetić, M.. (2018). N-acetyl-L-cysteine protects dental tissue stem cells against oxidative stress in vitro. in Clinical Oral Investigations
Springer Heidelberg, Heidelberg., 22(8), 2897-2903.
https://doi.org/10.1007/s00784-018-2377-2

Martačić J, Kovačević-Filipović M, Borozan S, Cvetković Z, Popović TB, Arsić A, Takić M, Vučić VM, Glibetić M. N-acetyl-L-cysteine protects dental tissue stem cells against oxidative stress in vitro. in Clinical Oral Investigations. 2018;22(8):2897-2903.
doi:10.1007/s00784-018-2377-2 .

Martačić, Jasmina, Kovačević-Filipović, Milica, Borozan, Sunčica, Cvetković, Zorica, Popović, Tamara B., Arsić, Aleksandra, Takić, Marija, Vučić, Vesna M., Glibetić, Marija, "N-acetyl-L-cysteine protects dental tissue stem cells against oxidative stress in vitro" in Clinical Oral Investigations, 22, no. 8 (2018):2897-2903,
https://doi.org/10.1007/s00784-018-2377-2 . .

TY  - JOUR
AU  - Vidović, Bojana
AU  - Milovanović, Srđan
AU  - Stefanović, Aleksandra
AU  - Kotur-Stevuljević, Jelena
AU  - Takić, Marija
AU  - Debeljak-Martačić, Jasmina
AU  - Pantović, Maja
AU  - Đorđević, Brižita
PY  - 2017
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/808
AB  - Adiponectin is an adipocyte-derived plasma protein with insulin-sensitizing and anti-inflammatory properties and is suggested to be a biomarker of metabolic disturbances. The aim of this study was to investigate the effects of alphalipoic acid (ALA) on plasma adiponectin and some metabolic risk factors in patients with schizophrenia. The plasma adipokine levels (adiponectin and leptin), routine biochemical and anthropometric parameters, markers of oxidative stress, and the serum phospholipid fatty acid profile in eighteen schizophrenic patients at baseline, in the middle, and at the end of a 3-month long supplementation period with ALA (500 mg daily) were determined. A significant increase in the plasma adiponectin concentrations, as well as a decrease in fasting glucose and aspartate aminotransferase activity (AST), was found. Baseline AST activity was independently correlated with the adiponectin concentrations. Our data show that ALA can improve plasma adiponectin levels and may play a potential role in the treatment of metabolic risk factor in patients with schizophrenia. Future randomized controlled trials are needed to confirm these preliminary investigations.
PB  - Mary Ann Liebert, Inc, New Rochelle
T2  - Journal of Medicinal Food
T1  - Effects of Alpha-Lipoic Acid Supplementation on Plasma Adiponectin Levels and Some Metabolic Risk Factors in Patients with Schizophrenia
EP  - 85
IS  - 1
SP  - 79
VL  - 20
DO  - 10.1089/jmf.2016.0070
ER  - 

@article{
author = "Vidović, Bojana and Milovanović, Srđan and Stefanović, Aleksandra and Kotur-Stevuljević, Jelena and Takić, Marija and Debeljak-Martačić, Jasmina and Pantović, Maja and Đorđević, Brižita",
year = "2017",
abstract = "Adiponectin is an adipocyte-derived plasma protein with insulin-sensitizing and anti-inflammatory properties and is suggested to be a biomarker of metabolic disturbances. The aim of this study was to investigate the effects of alphalipoic acid (ALA) on plasma adiponectin and some metabolic risk factors in patients with schizophrenia. The plasma adipokine levels (adiponectin and leptin), routine biochemical and anthropometric parameters, markers of oxidative stress, and the serum phospholipid fatty acid profile in eighteen schizophrenic patients at baseline, in the middle, and at the end of a 3-month long supplementation period with ALA (500 mg daily) were determined. A significant increase in the plasma adiponectin concentrations, as well as a decrease in fasting glucose and aspartate aminotransferase activity (AST), was found. Baseline AST activity was independently correlated with the adiponectin concentrations. Our data show that ALA can improve plasma adiponectin levels and may play a potential role in the treatment of metabolic risk factor in patients with schizophrenia. Future randomized controlled trials are needed to confirm these preliminary investigations.",
publisher = "Mary Ann Liebert, Inc, New Rochelle",
journal = "Journal of Medicinal Food",
title = "Effects of Alpha-Lipoic Acid Supplementation on Plasma Adiponectin Levels and Some Metabolic Risk Factors in Patients with Schizophrenia",
pages = "85-79",
number = "1",
volume = "20",
doi = "10.1089/jmf.2016.0070"
}

Vidović, B., Milovanović, S., Stefanović, A., Kotur-Stevuljević, J., Takić, M., Debeljak-Martačić, J., Pantović, M.,& Đorđević, B.. (2017). Effects of Alpha-Lipoic Acid Supplementation on Plasma Adiponectin Levels and Some Metabolic Risk Factors in Patients with Schizophrenia. in Journal of Medicinal Food
Mary Ann Liebert, Inc, New Rochelle., 20(1), 79-85.
https://doi.org/10.1089/jmf.2016.0070

Vidović B, Milovanović S, Stefanović A, Kotur-Stevuljević J, Takić M, Debeljak-Martačić J, Pantović M, Đorđević B. Effects of Alpha-Lipoic Acid Supplementation on Plasma Adiponectin Levels and Some Metabolic Risk Factors in Patients with Schizophrenia. in Journal of Medicinal Food. 2017;20(1):79-85.
doi:10.1089/jmf.2016.0070 .

Vidović, Bojana, Milovanović, Srđan, Stefanović, Aleksandra, Kotur-Stevuljević, Jelena, Takić, Marija, Debeljak-Martačić, Jasmina, Pantović, Maja, Đorđević, Brižita, "Effects of Alpha-Lipoic Acid Supplementation on Plasma Adiponectin Levels and Some Metabolic Risk Factors in Patients with Schizophrenia" in Journal of Medicinal Food, 20, no. 1 (2017):79-85,
https://doi.org/10.1089/jmf.2016.0070 . .