TY  - JOUR
AU  - Bumbaširević, Uroš
AU  - Petrović, Miloš
AU  - Zeković, Milica
AU  - Ćorić, Vesna
AU  - Milojević, Bogomir
AU  - Lisičić, Nikola
AU  - Obućina, David
AU  - Vasilić, Nenad
AU  - Bulat, Petar
AU  - Živković, Marko
AU  - Čekerevac, Milica
AU  - Bojanić, Nebojša
AU  - Janičić, Aleksandar
PY  - 2024
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1491
AB  - There are limited data regarding the significance of multifocality in testicular cancer patients. This study evaluated the relationship between multifocality and clinicopathological features determined at the time of radical orchiectomy. The study involved 280 consecutive patients who underwent radical orchiectomy between 2018 and 2023. Multifocality was defined as a distinct tumor focus characterized by a group of malignant cells > 1 mm, clearly differentiated from the primary tumor mass. Uni- and multivariate logistic regression analyses were employed to investigate the association between multifocality and histopathological parameters along with potential risk factors for clinical stages II + III. Multifocality was identified in 44 (15.7%) patients. Significantly smaller primary tumors were observed in subjects with multifocality (20.0 mm vs. 30.0 mm, p = 0.0001), while those exhibiting monofocality presented a markedly elevated rate of tumors exceeding 4 cm (40.3% vs. 18.2%, p = 0.005). Furthermore, multifocality was associated with a significantly higher rate of primary tumors < 2 cm (52.3% vs. 29.2%, p = 0.003). Univariate logistic regression analysis revealed a substantial decrease in the likelihood of multifocality occurrence in seminoma patients with tumors > 4 cm (OR = 0.38, p = 0.017). Meanwhile, in multivariate logistic regression, multifocality did not emerge as a significant risk factor for clinical stages II + III in either seminoma (p = 0.381) or non-seminoma (p = 0.672) cases. Our study suggests that multifocality holds no substantial prognostic relevance for clinically advanced disease in testicular cancer patients. The findings indicate that multifocality is associated with smaller primary tumors, particularly those measuring less than 2 cm.
PB  - Basel : Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Life
T2  - Life
T1  - Multifocality in Testicular Cancer: Clinicopathological Correlations and Prognostic Implications
IS  - 2
SP  - 257
VL  - 14
DO  - 10.3390/life14020257
ER  - 

@article{
author = "Bumbaširević, Uroš and Petrović, Miloš and Zeković, Milica and Ćorić, Vesna and Milojević, Bogomir and Lisičić, Nikola and Obućina, David and Vasilić, Nenad and Bulat, Petar and Živković, Marko and Čekerevac, Milica and Bojanić, Nebojša and Janičić, Aleksandar",
year = "2024",
abstract = "There are limited data regarding the significance of multifocality in testicular cancer patients. This study evaluated the relationship between multifocality and clinicopathological features determined at the time of radical orchiectomy. The study involved 280 consecutive patients who underwent radical orchiectomy between 2018 and 2023. Multifocality was defined as a distinct tumor focus characterized by a group of malignant cells > 1 mm, clearly differentiated from the primary tumor mass. Uni- and multivariate logistic regression analyses were employed to investigate the association between multifocality and histopathological parameters along with potential risk factors for clinical stages II + III. Multifocality was identified in 44 (15.7%) patients. Significantly smaller primary tumors were observed in subjects with multifocality (20.0 mm vs. 30.0 mm, p = 0.0001), while those exhibiting monofocality presented a markedly elevated rate of tumors exceeding 4 cm (40.3% vs. 18.2%, p = 0.005). Furthermore, multifocality was associated with a significantly higher rate of primary tumors < 2 cm (52.3% vs. 29.2%, p = 0.003). Univariate logistic regression analysis revealed a substantial decrease in the likelihood of multifocality occurrence in seminoma patients with tumors > 4 cm (OR = 0.38, p = 0.017). Meanwhile, in multivariate logistic regression, multifocality did not emerge as a significant risk factor for clinical stages II + III in either seminoma (p = 0.381) or non-seminoma (p = 0.672) cases. Our study suggests that multifocality holds no substantial prognostic relevance for clinically advanced disease in testicular cancer patients. The findings indicate that multifocality is associated with smaller primary tumors, particularly those measuring less than 2 cm.",
publisher = "Basel : Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Life, Life",
title = "Multifocality in Testicular Cancer: Clinicopathological Correlations and Prognostic Implications",
number = "2",
pages = "257",
volume = "14",
doi = "10.3390/life14020257"
}

Bumbaširević, U., Petrović, M., Zeković, M., Ćorić, V., Milojević, B., Lisičić, N., Obućina, D., Vasilić, N., Bulat, P., Živković, M., Čekerevac, M., Bojanić, N.,& Janičić, A.. (2024). Multifocality in Testicular Cancer: Clinicopathological Correlations and Prognostic Implications. in Life
Basel : Multidisciplinary Digital Publishing Institute (MDPI)., 14(2), 257.
https://doi.org/10.3390/life14020257

Bumbaširević U, Petrović M, Zeković M, Ćorić V, Milojević B, Lisičić N, Obućina D, Vasilić N, Bulat P, Živković M, Čekerevac M, Bojanić N, Janičić A. Multifocality in Testicular Cancer: Clinicopathological Correlations and Prognostic Implications. in Life. 2024;14(2):257.
doi:10.3390/life14020257 .

Bumbaširević, Uroš, Petrović, Miloš, Zeković, Milica, Ćorić, Vesna, Milojević, Bogomir, Lisičić, Nikola, Obućina, David, Vasilić, Nenad, Bulat, Petar, Živković, Marko, Čekerevac, Milica, Bojanić, Nebojša, Janičić, Aleksandar, "Multifocality in Testicular Cancer: Clinicopathological Correlations and Prognostic Implications" in Life, 14, no. 2 (2024):257,
https://doi.org/10.3390/life14020257 . .

TY  - JOUR
AU  - Petrović, Miloš
AU  - Simić, Tatjana
AU  - Đukić, Tatjana
AU  - Radić, Tanja
AU  - Savić-Radojević, Ana
AU  - Zeković, Milica
AU  - Durutović, Otaš
AU  - Janičić, Aleksandar
AU  - Milojević, Bogomir
AU  - Kajmaković, Boris
AU  - Živković, Marko
AU  - Bojanić, Nebojša
AU  - Bumbaširević, Uroš
AU  - Ćorić, Vesna
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1304
AB  - Members of the omega class of glutathione transferases (GSTs), GSTO1, and GSTO2, catalyze a range of reduction reactions as a part of the antioxidant defense system. Polymorphisms of genes encoding antioxidant proteins and the resultant altered redox profile have already been associated with the increased risk for testicular germ cell cancer (GCT) development. The aim of this pilot study was to assess the individual, combined, haplotype, and cumulative effect of GSTO1rs4925, GSTO2rs156697, and GSTO2rs2297235 polymorphisms with the risk for testicular GCT development, in 88 patients and 96 matched controls, through logistic regression models. We found that carriers of the GSTO1*C/A*C/C genotype exhibited an increased risk for testicular GCT development. Significant association with increased risk of testicular GCT was observed in carriers of GSTO2rs2297235*A/G*G/G genotype, and in carriers of combined GSTO2rs156697*A/G*G/G and GSTO2rs2297235*A/G*G/G genotypes. Haplotype H7 (GSTO1rs4925*C/GSTO2rs2297235*G/GSTO2rs156697*G) exhibited higher risk of testicular GCT, however, without significant association (p > 0.05). Finally, 51% of testicular GCT patients were the carriers of all three risk-associated genotypes, with 2.5-fold increased cumulative risk. In conclusion, the results of this pilot study suggest that GSTO polymorphisms might affect the protective antioxidant activity of GSTO isoenzymes, therefore predisposing susceptible individuals toward higher risk for testicular GCT development.
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Life
T1  - The Polymorphisms in GSTO Genes (GSTO1 rs4925, GSTO2 rs156697, and GSTO2 rs2297235) Affect the Risk for Testicular Germ Cell Tumor Development: A Pilot Study
IS  - 6
SP  - 1269
VL  - 13
DO  - 10.3390/life13061269
ER  - 

@article{
author = "Petrović, Miloš and Simić, Tatjana and Đukić, Tatjana and Radić, Tanja and Savić-Radojević, Ana and Zeković, Milica and Durutović, Otaš and Janičić, Aleksandar and Milojević, Bogomir and Kajmaković, Boris and Živković, Marko and Bojanić, Nebojša and Bumbaširević, Uroš and Ćorić, Vesna",
year = "2023",
abstract = "Members of the omega class of glutathione transferases (GSTs), GSTO1, and GSTO2, catalyze a range of reduction reactions as a part of the antioxidant defense system. Polymorphisms of genes encoding antioxidant proteins and the resultant altered redox profile have already been associated with the increased risk for testicular germ cell cancer (GCT) development. The aim of this pilot study was to assess the individual, combined, haplotype, and cumulative effect of GSTO1rs4925, GSTO2rs156697, and GSTO2rs2297235 polymorphisms with the risk for testicular GCT development, in 88 patients and 96 matched controls, through logistic regression models. We found that carriers of the GSTO1*C/A*C/C genotype exhibited an increased risk for testicular GCT development. Significant association with increased risk of testicular GCT was observed in carriers of GSTO2rs2297235*A/G*G/G genotype, and in carriers of combined GSTO2rs156697*A/G*G/G and GSTO2rs2297235*A/G*G/G genotypes. Haplotype H7 (GSTO1rs4925*C/GSTO2rs2297235*G/GSTO2rs156697*G) exhibited higher risk of testicular GCT, however, without significant association (p > 0.05). Finally, 51% of testicular GCT patients were the carriers of all three risk-associated genotypes, with 2.5-fold increased cumulative risk. In conclusion, the results of this pilot study suggest that GSTO polymorphisms might affect the protective antioxidant activity of GSTO isoenzymes, therefore predisposing susceptible individuals toward higher risk for testicular GCT development.",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Life",
title = "The Polymorphisms in GSTO Genes (GSTO1 rs4925, GSTO2 rs156697, and GSTO2 rs2297235) Affect the Risk for Testicular Germ Cell Tumor Development: A Pilot Study",
number = "6",
pages = "1269",
volume = "13",
doi = "10.3390/life13061269"
}

Petrović, M., Simić, T., Đukić, T., Radić, T., Savić-Radojević, A., Zeković, M., Durutović, O., Janičić, A., Milojević, B., Kajmaković, B., Živković, M., Bojanić, N., Bumbaširević, U.,& Ćorić, V.. (2023). The Polymorphisms in GSTO Genes (GSTO1 rs4925, GSTO2 rs156697, and GSTO2 rs2297235) Affect the Risk for Testicular Germ Cell Tumor Development: A Pilot Study. in Life
Multidisciplinary Digital Publishing Institute (MDPI)., 13(6), 1269.
https://doi.org/10.3390/life13061269

Petrović M, Simić T, Đukić T, Radić T, Savić-Radojević A, Zeković M, Durutović O, Janičić A, Milojević B, Kajmaković B, Živković M, Bojanić N, Bumbaširević U, Ćorić V. The Polymorphisms in GSTO Genes (GSTO1 rs4925, GSTO2 rs156697, and GSTO2 rs2297235) Affect the Risk for Testicular Germ Cell Tumor Development: A Pilot Study. in Life. 2023;13(6):1269.
doi:10.3390/life13061269 .

Petrović, Miloš, Simić, Tatjana, Đukić, Tatjana, Radić, Tanja, Savić-Radojević, Ana, Zeković, Milica, Durutović, Otaš, Janičić, Aleksandar, Milojević, Bogomir, Kajmaković, Boris, Živković, Marko, Bojanić, Nebojša, Bumbaširević, Uroš, Ćorić, Vesna, "The Polymorphisms in GSTO Genes (GSTO1 rs4925, GSTO2 rs156697, and GSTO2 rs2297235) Affect the Risk for Testicular Germ Cell Tumor Development: A Pilot Study" in Life, 13, no. 6 (2023):1269,
https://doi.org/10.3390/life13061269 . .

TY  - JOUR
AU  - Čegar, Bojan
AU  - Šipetić Grujičić, Sandra
AU  - Bjekić, Jovana
AU  - Vuksanović, Aleksandar
AU  - Bojanić, Nebojša
AU  - Bartolović, Daniela
AU  - Jovanović, Darko
AU  - Zeković, Milica
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1347
AB  - The experience of an infertility diagnosis and treatment imposes a profound burden on affected individuals, encompassing not only physical and medical aspects but also a plethora of psychological, social, and emotional factors. By employing a multimodal assessment featuring validated self-report questionnaires, physical measurements, and clinical records, the present study aimed to explore the quality of life and psycho-emotional distress of men undergoing infertility treatment in Serbia, thereby addressing the dearth of research on the underrepresented male perspective in this domain. Findings revealed diverse semen abnormalities among participants (n = 96, average age 37.69 ± 5.72), with significant associations between longer treatment durations and reduced sperm motility. The observed rates of men surpassing predetermined DASS-42 questionnaire thresholds for depression, anxiety, and stress in the analyzed cohort were 13.54%, 11.46%, and 22.92%, respectively. Summary scores in conceptual areas comprised in the SF-36 questionnaire ranged from 49.00 ± 6.25 for the mental health dimension to 90.16 ± 17.75 obtained in the physical functioning subscale. Patients with a longer treatment duration demonstrated lower scores in the role emotional domain, indicative of a less favorable emotional state. Expectedly, inverse correlations were found between the SF-36 mental health score and DASS-42 subscales. By addressing the existing knowledge gap and highlighting the unique needs of infertile men, the finding of this study may contribute to a more inclusive and holistic approach to infertility research and management.
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Life
T1  - Understanding the Male Perspective: Evaluating Quality of Life and Psychological Distress in Serbian Men Undergoing Infertility Treatment
IS  - 9
SP  - 1894
VL  - 13
DO  - 10.3390/life13091894
ER  - 

@article{
author = "Čegar, Bojan and Šipetić Grujičić, Sandra and Bjekić, Jovana and Vuksanović, Aleksandar and Bojanić, Nebojša and Bartolović, Daniela and Jovanović, Darko and Zeković, Milica",
year = "2023",
abstract = "The experience of an infertility diagnosis and treatment imposes a profound burden on affected individuals, encompassing not only physical and medical aspects but also a plethora of psychological, social, and emotional factors. By employing a multimodal assessment featuring validated self-report questionnaires, physical measurements, and clinical records, the present study aimed to explore the quality of life and psycho-emotional distress of men undergoing infertility treatment in Serbia, thereby addressing the dearth of research on the underrepresented male perspective in this domain. Findings revealed diverse semen abnormalities among participants (n = 96, average age 37.69 ± 5.72), with significant associations between longer treatment durations and reduced sperm motility. The observed rates of men surpassing predetermined DASS-42 questionnaire thresholds for depression, anxiety, and stress in the analyzed cohort were 13.54%, 11.46%, and 22.92%, respectively. Summary scores in conceptual areas comprised in the SF-36 questionnaire ranged from 49.00 ± 6.25 for the mental health dimension to 90.16 ± 17.75 obtained in the physical functioning subscale. Patients with a longer treatment duration demonstrated lower scores in the role emotional domain, indicative of a less favorable emotional state. Expectedly, inverse correlations were found between the SF-36 mental health score and DASS-42 subscales. By addressing the existing knowledge gap and highlighting the unique needs of infertile men, the finding of this study may contribute to a more inclusive and holistic approach to infertility research and management.",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Life",
title = "Understanding the Male Perspective: Evaluating Quality of Life and Psychological Distress in Serbian Men Undergoing Infertility Treatment",
number = "9",
pages = "1894",
volume = "13",
doi = "10.3390/life13091894"
}

Čegar, B., Šipetić Grujičić, S., Bjekić, J., Vuksanović, A., Bojanić, N., Bartolović, D., Jovanović, D.,& Zeković, M.. (2023). Understanding the Male Perspective: Evaluating Quality of Life and Psychological Distress in Serbian Men Undergoing Infertility Treatment. in Life
Multidisciplinary Digital Publishing Institute (MDPI)., 13(9), 1894.
https://doi.org/10.3390/life13091894

Čegar B, Šipetić Grujičić S, Bjekić J, Vuksanović A, Bojanić N, Bartolović D, Jovanović D, Zeković M. Understanding the Male Perspective: Evaluating Quality of Life and Psychological Distress in Serbian Men Undergoing Infertility Treatment. in Life. 2023;13(9):1894.
doi:10.3390/life13091894 .

Čegar, Bojan, Šipetić Grujičić, Sandra, Bjekić, Jovana, Vuksanović, Aleksandar, Bojanić, Nebojša, Bartolović, Daniela, Jovanović, Darko, Zeković, Milica, "Understanding the Male Perspective: Evaluating Quality of Life and Psychological Distress in Serbian Men Undergoing Infertility Treatment" in Life, 13, no. 9 (2023):1894,
https://doi.org/10.3390/life13091894 . .

TY  - JOUR
AU  - Janičić, Aleksandar
AU  - Petrović, Miloš
AU  - Zeković, Milica
AU  - Vasilić, Nenad
AU  - Ćorić, Vesna
AU  - Milojević, Bogomir
AU  - Živković, Marko
AU  - Bumbaširević, Uroš
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1285
AB  - In contemporary clinical practice, biomarkers are indispensable in the assessment and management of oncological patients. Although established serum tumor markers (beta human chorionic gonadotropin (bHCG), alpha fetoprotein (AFP), and lactate dehydrogenase (LDH)) have an indisputably important role in the management of patients with testicular cancer (TC), the application of these tumor markers may be accompanied with certain limitations, implying the need for additional biomarkers. Contrary to TC, there is a lack of established serological biomarkers for penile cancer (PC) and the management of this urological malignancy is based on multiple clinicopathological parameters. Therefore, the identification and rigorous analytical and clinical validation of reliable biomarkers are considered pivotal for improving PC management. Inflammation may be associated with all stages of oncogenesis, from initial neoplastic transformation to angiogenesis, tissue invasion, and metastasis. Accordingly, an array of inflammation-related indices have gained increasing attention as emerging predictors of oncological outcomes. The clinical usefulness of systemic inflammation markers was reported in many urological and non-urological malignancies. The aim of this narrative review is to summarize current scientific data regarding the prognostic and predictive significance of systemic inflammation markers in TC and PC patients.
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Life
T1  - Prognostic Significance of Systemic Inflammation Markers in Testicular and Penile Cancer: A Narrative Review of Current Literature
IS  - 3
SP  - 600
VL  - 13
DO  - 10.3390/life13030600
UR  - https://hdl.handle.net/21.15107/rcub_rimi_1285
ER  - 

@article{
author = "Janičić, Aleksandar and Petrović, Miloš and Zeković, Milica and Vasilić, Nenad and Ćorić, Vesna and Milojević, Bogomir and Živković, Marko and Bumbaširević, Uroš",
year = "2023",
abstract = "In contemporary clinical practice, biomarkers are indispensable in the assessment and management of oncological patients. Although established serum tumor markers (beta human chorionic gonadotropin (bHCG), alpha fetoprotein (AFP), and lactate dehydrogenase (LDH)) have an indisputably important role in the management of patients with testicular cancer (TC), the application of these tumor markers may be accompanied with certain limitations, implying the need for additional biomarkers. Contrary to TC, there is a lack of established serological biomarkers for penile cancer (PC) and the management of this urological malignancy is based on multiple clinicopathological parameters. Therefore, the identification and rigorous analytical and clinical validation of reliable biomarkers are considered pivotal for improving PC management. Inflammation may be associated with all stages of oncogenesis, from initial neoplastic transformation to angiogenesis, tissue invasion, and metastasis. Accordingly, an array of inflammation-related indices have gained increasing attention as emerging predictors of oncological outcomes. The clinical usefulness of systemic inflammation markers was reported in many urological and non-urological malignancies. The aim of this narrative review is to summarize current scientific data regarding the prognostic and predictive significance of systemic inflammation markers in TC and PC patients.",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Life",
title = "Prognostic Significance of Systemic Inflammation Markers in Testicular and Penile Cancer: A Narrative Review of Current Literature",
number = "3",
pages = "600",
volume = "13",
doi = "10.3390/life13030600",
url = "https://hdl.handle.net/21.15107/rcub_rimi_1285"
}

Janičić, A., Petrović, M., Zeković, M., Vasilić, N., Ćorić, V., Milojević, B., Živković, M.,& Bumbaširević, U.. (2023). Prognostic Significance of Systemic Inflammation Markers in Testicular and Penile Cancer: A Narrative Review of Current Literature. in Life
Multidisciplinary Digital Publishing Institute (MDPI)., 13(3), 600.
https://doi.org/10.3390/life13030600
https://hdl.handle.net/21.15107/rcub_rimi_1285

Janičić A, Petrović M, Zeković M, Vasilić N, Ćorić V, Milojević B, Živković M, Bumbaširević U. Prognostic Significance of Systemic Inflammation Markers in Testicular and Penile Cancer: A Narrative Review of Current Literature. in Life. 2023;13(3):600.
doi:10.3390/life13030600
https://hdl.handle.net/21.15107/rcub_rimi_1285 .

Janičić, Aleksandar, Petrović, Miloš, Zeković, Milica, Vasilić, Nenad, Ćorić, Vesna, Milojević, Bogomir, Živković, Marko, Bumbaširević, Uroš, "Prognostic Significance of Systemic Inflammation Markers in Testicular and Penile Cancer: A Narrative Review of Current Literature" in Life, 13, no. 3 (2023):600,
https://doi.org/10.3390/life13030600 .,
https://hdl.handle.net/21.15107/rcub_rimi_1285 .

TY  - CONF
AU  - Milešević, Jelena
AU  - Zeković, Milica
AU  - Šarac, Ivana
AU  - Knez, Marija
AU  - Takić, Marija
AU  - Debeljak Martačić, Jasmina
AU  - Gurinović, Mirjana
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1432
AB  - The Serbian National Food Consumption Survey on adults from 10 to 74 years old, including pregnant women and vegetarians, was conducted in compliance with the EFSA EU Menu project support and guidance from 2017 to 2022. Valid data were collected from a total of 3018 participants with 856 adolescents aged 10 to 17 years, 1155 adults aged 18 to 64, 581 elderly subjects aged 65 to 74 years, 145 pregnant women, and 281 persons following a vegetarian diet. Data collection was conducted using a national Survey Pack designed for the project, including the following: a general questionnaire, an age-appropriate Food Propensity Questionnaire, an International Physical Activity Questionnaire, and 24 h dietary recall. The advanced nutritional platform Diet Assess and Plan (DAP) was applied for data storage, processing, and the creation of the final dataset for transfer to EFSA. The Serbian food composition database was used and updated during the project as a resource of food information for all foods and recipes that were consumed by the study cohort. Regardless of age and
gender category, the majority (56%) of adults had normal weight according to the Body Mass Index,while 21% were overweight, and 15.5% were underweight. The average daily energy intake was 2178.72 kcal, while overall contributions of carbohydrates, protein, and fat to the total energy intake were 43.37%, 15.47%, and 41.16%, respectively. The proportions of macronutrient intake deviated from the dietary reference values, particularly for fat, which was often too high, where sunflower oil was the major source of fat in diets. Out of the 3018 participants, 98% had breakfast, 99% had lunch,
and 95% had dinner, while approx. 80% had snacks between main meals. The highest energy intake was recorded during lunch, 706.5 kcal (32% TE). The survey results provide valuable insight into the nutritional status and dietary habits of adults from 10 to 74 years old living in Serbia. The Serbian food consumption database serves as an evidence platform for decision-making processes in public health nutrition policies and strategies, diet monitoring, exposure risk assessments, and interventions targeting identified nutritional challenges in particular population groups. Harmonized data are part of the EFSA comprehensive food consumption database.
PB  - Basel, Switzerland: MDPI (Multidisciplinary Digital Publishing Institute)
C3  - Proceedings of The 14th European Nutrition Conference FENS 2023: “Food, Nutrition and Health:Translating Science into Practice”, 14 to 17 November 2023, Belgrade, Serbia
T1  - Nutritional and Anthropometric Status of Serbian Adults 10–74 Years Old: Results from European Food Safety Authority (EFSA) EU Menu Food Consumption Survey 2017–2021
IS  - 1
SP  - 15
VL  - 91
DO  - 10.3390/proceedings2023091015
ER  - 

@conference{
author = "Milešević, Jelena and Zeković, Milica and Šarac, Ivana and Knez, Marija and Takić, Marija and Debeljak Martačić, Jasmina and Gurinović, Mirjana",
year = "2023",
abstract = "The Serbian National Food Consumption Survey on adults from 10 to 74 years old, including pregnant women and vegetarians, was conducted in compliance with the EFSA EU Menu project support and guidance from 2017 to 2022. Valid data were collected from a total of 3018 participants with 856 adolescents aged 10 to 17 years, 1155 adults aged 18 to 64, 581 elderly subjects aged 65 to 74 years, 145 pregnant women, and 281 persons following a vegetarian diet. Data collection was conducted using a national Survey Pack designed for the project, including the following: a general questionnaire, an age-appropriate Food Propensity Questionnaire, an International Physical Activity Questionnaire, and 24 h dietary recall. The advanced nutritional platform Diet Assess and Plan (DAP) was applied for data storage, processing, and the creation of the final dataset for transfer to EFSA. The Serbian food composition database was used and updated during the project as a resource of food information for all foods and recipes that were consumed by the study cohort. Regardless of age and
gender category, the majority (56%) of adults had normal weight according to the Body Mass Index,while 21% were overweight, and 15.5% were underweight. The average daily energy intake was 2178.72 kcal, while overall contributions of carbohydrates, protein, and fat to the total energy intake were 43.37%, 15.47%, and 41.16%, respectively. The proportions of macronutrient intake deviated from the dietary reference values, particularly for fat, which was often too high, where sunflower oil was the major source of fat in diets. Out of the 3018 participants, 98% had breakfast, 99% had lunch,
and 95% had dinner, while approx. 80% had snacks between main meals. The highest energy intake was recorded during lunch, 706.5 kcal (32% TE). The survey results provide valuable insight into the nutritional status and dietary habits of adults from 10 to 74 years old living in Serbia. The Serbian food consumption database serves as an evidence platform for decision-making processes in public health nutrition policies and strategies, diet monitoring, exposure risk assessments, and interventions targeting identified nutritional challenges in particular population groups. Harmonized data are part of the EFSA comprehensive food consumption database.",
publisher = "Basel, Switzerland: MDPI (Multidisciplinary Digital Publishing Institute)",
journal = "Proceedings of The 14th European Nutrition Conference FENS 2023: “Food, Nutrition and Health:Translating Science into Practice”, 14 to 17 November 2023, Belgrade, Serbia",
title = "Nutritional and Anthropometric Status of Serbian Adults 10–74 Years Old: Results from European Food Safety Authority (EFSA) EU Menu Food Consumption Survey 2017–2021",
number = "1",
pages = "15",
volume = "91",
doi = "10.3390/proceedings2023091015"
}

Milešević, J., Zeković, M., Šarac, I., Knez, M., Takić, M., Debeljak Martačić, J.,& Gurinović, M.. (2023). Nutritional and Anthropometric Status of Serbian Adults 10–74 Years Old: Results from European Food Safety Authority (EFSA) EU Menu Food Consumption Survey 2017–2021. in Proceedings of The 14th European Nutrition Conference FENS 2023: “Food, Nutrition and Health:Translating Science into Practice”, 14 to 17 November 2023, Belgrade, Serbia
Basel, Switzerland: MDPI (Multidisciplinary Digital Publishing Institute)., 91(1), 15.
https://doi.org/10.3390/proceedings2023091015

Milešević J, Zeković M, Šarac I, Knez M, Takić M, Debeljak Martačić J, Gurinović M. Nutritional and Anthropometric Status of Serbian Adults 10–74 Years Old: Results from European Food Safety Authority (EFSA) EU Menu Food Consumption Survey 2017–2021. in Proceedings of The 14th European Nutrition Conference FENS 2023: “Food, Nutrition and Health:Translating Science into Practice”, 14 to 17 November 2023, Belgrade, Serbia. 2023;91(1):15.
doi:10.3390/proceedings2023091015 .

Milešević, Jelena, Zeković, Milica, Šarac, Ivana, Knez, Marija, Takić, Marija, Debeljak Martačić, Jasmina, Gurinović, Mirjana, "Nutritional and Anthropometric Status of Serbian Adults 10–74 Years Old: Results from European Food Safety Authority (EFSA) EU Menu Food Consumption Survey 2017–2021" in Proceedings of The 14th European Nutrition Conference FENS 2023: “Food, Nutrition and Health:Translating Science into Practice”, 14 to 17 November 2023, Belgrade, Serbia, 91, no. 1 (2023):15,
https://doi.org/10.3390/proceedings2023091015 . .

TY  - CONF
AU  - Gurinović, Mirjana
AU  - Milešević, Jelena
AU  - Zeković, Milica
AU  - Knez, Marija
AU  - Takić, Marija
AU  - Šarac, Ivana
AU  - Kadvan, Agneš
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1441
AB  - Harmonized and standardized collection, processing, and analysis of individual dietary data is essential for nutrition assessment and informed policy decision making. To underpin the harmonization of food consumption data collection methodologies and the development of a common, comprehensive European food consumption database, the European Food Safety Authority (EFSA) supported 36 child and/or adult dietary surveys in 18 EU Member States and four Balkan preaccession countries through the EU Menu Project. Given the lack of relevant and harmonized research and data on food and nutrition in the Balkan region, CENM-IMR and CAPNUTRA scientists focused their activities on capacity building in nutrition research, particularly on the creation of a contemporary, harmonized research infrastructure (RI) that meets European standards. The EFSA EU Menu methodology has been implemented in the Balkans through the adaptation and use of an innovative, comprehensive tool for the standardized collection of food consumption and dietary intake assessment data, the Diet Assess and Plan (DAP). DAP has the essential features of an RI needed to strengthen public health surveillance, monitoring, evaluation, and nutrition research; this is a unique example of a standardized and harmonized tool for assessing dietary intake, i.e., collecting data on food and nutrition in the Balkan region and beyond. It is a concurrent tool for large-scale nutritional epidemiological studies and represents one of the new technologies for dietary intake assessment. National dietary surveys were conducted from 2017 to 2023 among adults aged 10 to 74 years (in Bosnia and Herzegovina, Montenegro, and Serbia) and children aged three months to nine years (in Montenegro, North Macedonia, and Serbia). The collected data on food consumption are internationally comparable with other European countries under the EU Menu Program. The data collected will be used for dietary and exposure risk assessment, establishment of national nutrient reference values, as a basis for the development of food-based dietary guidelines, a tool to provide evidence and infrastructure for public health nutrition policy decisions, and for tailored pathways to transform the food system in the Balkans towards a more nutrition-sensitive and sustainable system.
PB  - Basel, Switzerland: MDPI (Multidisciplinary Digital Publishing Institute)
C3  - Proceedings of The 14th European Nutrition Conference FENS 2023: “Food, Nutrition and Health:Translating Science into Practice”, 14 to 17 November 2023, Belgrade, Serbia
T1  - Capacity Development and Harmonization of Food Consumption Data Collection in EFSA EU Menu National Dietary Surveys in Balkan Region-Building: The Evidence Base for Diet Monitoring and Food Systems Transformation
IS  - 1
SP  - 24
VL  - 91
DO  - 10.3390/proceedings2023091024
ER  - 

@conference{
author = "Gurinović, Mirjana and Milešević, Jelena and Zeković, Milica and Knez, Marija and Takić, Marija and Šarac, Ivana and Kadvan, Agneš",
year = "2023",
abstract = "Harmonized and standardized collection, processing, and analysis of individual dietary data is essential for nutrition assessment and informed policy decision making. To underpin the harmonization of food consumption data collection methodologies and the development of a common, comprehensive European food consumption database, the European Food Safety Authority (EFSA) supported 36 child and/or adult dietary surveys in 18 EU Member States and four Balkan preaccession countries through the EU Menu Project. Given the lack of relevant and harmonized research and data on food and nutrition in the Balkan region, CENM-IMR and CAPNUTRA scientists focused their activities on capacity building in nutrition research, particularly on the creation of a contemporary, harmonized research infrastructure (RI) that meets European standards. The EFSA EU Menu methodology has been implemented in the Balkans through the adaptation and use of an innovative, comprehensive tool for the standardized collection of food consumption and dietary intake assessment data, the Diet Assess and Plan (DAP). DAP has the essential features of an RI needed to strengthen public health surveillance, monitoring, evaluation, and nutrition research; this is a unique example of a standardized and harmonized tool for assessing dietary intake, i.e., collecting data on food and nutrition in the Balkan region and beyond. It is a concurrent tool for large-scale nutritional epidemiological studies and represents one of the new technologies for dietary intake assessment. National dietary surveys were conducted from 2017 to 2023 among adults aged 10 to 74 years (in Bosnia and Herzegovina, Montenegro, and Serbia) and children aged three months to nine years (in Montenegro, North Macedonia, and Serbia). The collected data on food consumption are internationally comparable with other European countries under the EU Menu Program. The data collected will be used for dietary and exposure risk assessment, establishment of national nutrient reference values, as a basis for the development of food-based dietary guidelines, a tool to provide evidence and infrastructure for public health nutrition policy decisions, and for tailored pathways to transform the food system in the Balkans towards a more nutrition-sensitive and sustainable system.",
publisher = "Basel, Switzerland: MDPI (Multidisciplinary Digital Publishing Institute)",
journal = "Proceedings of The 14th European Nutrition Conference FENS 2023: “Food, Nutrition and Health:Translating Science into Practice”, 14 to 17 November 2023, Belgrade, Serbia",
title = "Capacity Development and Harmonization of Food Consumption Data Collection in EFSA EU Menu National Dietary Surveys in Balkan Region-Building: The Evidence Base for Diet Monitoring and Food Systems Transformation",
number = "1",
pages = "24",
volume = "91",
doi = "10.3390/proceedings2023091024"
}

Gurinović, M., Milešević, J., Zeković, M., Knez, M., Takić, M., Šarac, I.,& Kadvan, A.. (2023). Capacity Development and Harmonization of Food Consumption Data Collection in EFSA EU Menu National Dietary Surveys in Balkan Region-Building: The Evidence Base for Diet Monitoring and Food Systems Transformation. in Proceedings of The 14th European Nutrition Conference FENS 2023: “Food, Nutrition and Health:Translating Science into Practice”, 14 to 17 November 2023, Belgrade, Serbia
Basel, Switzerland: MDPI (Multidisciplinary Digital Publishing Institute)., 91(1), 24.
https://doi.org/10.3390/proceedings2023091024

Gurinović M, Milešević J, Zeković M, Knez M, Takić M, Šarac I, Kadvan A. Capacity Development and Harmonization of Food Consumption Data Collection in EFSA EU Menu National Dietary Surveys in Balkan Region-Building: The Evidence Base for Diet Monitoring and Food Systems Transformation. in Proceedings of The 14th European Nutrition Conference FENS 2023: “Food, Nutrition and Health:Translating Science into Practice”, 14 to 17 November 2023, Belgrade, Serbia. 2023;91(1):24.
doi:10.3390/proceedings2023091024 .

Gurinović, Mirjana, Milešević, Jelena, Zeković, Milica, Knez, Marija, Takić, Marija, Šarac, Ivana, Kadvan, Agneš, "Capacity Development and Harmonization of Food Consumption Data Collection in EFSA EU Menu National Dietary Surveys in Balkan Region-Building: The Evidence Base for Diet Monitoring and Food Systems Transformation" in Proceedings of The 14th European Nutrition Conference FENS 2023: “Food, Nutrition and Health:Translating Science into Practice”, 14 to 17 November 2023, Belgrade, Serbia, 91, no. 1 (2023):24,
https://doi.org/10.3390/proceedings2023091024 . .

TY  - JOUR
AU  - Šarac, Ivana
AU  - Debeljak-Martačić, Jasmina
AU  - Takić, Marija
AU  - Stevanović, Vuk
AU  - Milešević, Jelena
AU  - Zeković, Milica
AU  - Popović, Tamara B.
AU  - Jovanović, Jovica
AU  - Kardum Vidović, Nevena
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1345
AB  - Introduction: Fatty acids (FAs) composition and desaturase activities can be altered in different metabolic conditions, but the adiposity-independent associations with clinical and biochemical indicators of cardiometabolic risk are still unclear. This study aimed to analyze the associations of FAs composition and estimated desaturase activities with anthropometric, clinical, and biochemical cardiometabolic risk indicators in non-diabetic Serbian women, and to investigate if these associations were independent of the level of adiposity and other confounders.

Methods: In 76 non-diabetic, otherwise healthy Serbian women, aged 24-68 years, with or without metabolic syndrome or obesity (BMI=23.6±5.6 kg/m2), FA composition in erythrocyte phospholipids was measured by gas-liquid chromatography. Desaturase activities were estimated from product/precursor FAs ratios (D9D:16:1n-7/16:0; D6D:20:3n-6/18:2n-6; D5D:20:4n-6/20:3n-6). Correlations were made with anthropometric, biochemical (serum glucose, triacylglycerols, LDL-C, HDL-C, ALT, AST, and their ratios) and clinical (blood pressure) indicators of cardiometabolic risk. Linear regression models were performed to test the independence of these associations.

Results: Estimated desaturase activities and certain FAs were associated with anthropometric, clinical and biochemical indicators of cardiometabolic risk: D9D, D6D, 16:1n-7 and 20:3n-6 were directly associated, while D5D and 18:0 were inversely associated. However, the associations with clinical and biochemical indicators were not independent of the associations with the level of adiposity, since they were lost after controlling for anthropometric indices. After controlling for multiple confounders (age, postmenopausal status, education, smoking, physical activity, dietary macronutrient intakes, use of supplements, alcohol consumption), the level of adiposity was the most significant predictor of desaturase activities and aforementioned FAs levels, and mediated their association with biochemical/clinical indicators. Vice versa, desaturase activities predicted the level of adiposity, but not other components of cardiometabolic risk (if the level of adiposity was accounted). While the associations of anthropometric indices with 16:1n-7, 20:3n-6, 18:0 and D9D and D6D activities were linear, the associations with D5D activity were the inverse U-shaped. The only adiposity-independent association of FAs profiles with the indicators of cardiometabolic risk was a positive association of 20:5n-3 with ALT/AST ratio, which requires further exploration.

Discussion: Additional studies are needed to explore the mechanisms of the observed associations.
PB  - Frontiers Media S.A.
T2  - Frontiers in Nutrition
T1  - Associations of fatty acids composition and estimated desaturase activities in erythrocyte phospholipids with biochemical and clinical indicators of cardiometabolic risk in non-diabetic Serbian women: the role of level of adiposity
VL  - 10
DO  - 10.3389/fnut.2023.1065578
UR  - https://hdl.handle.net/21.15107/rcub_rimi_1345
ER  - 

@article{
author = "Šarac, Ivana and Debeljak-Martačić, Jasmina and Takić, Marija and Stevanović, Vuk and Milešević, Jelena and Zeković, Milica and Popović, Tamara B. and Jovanović, Jovica and Kardum Vidović, Nevena",
year = "2023",
abstract = "Introduction: Fatty acids (FAs) composition and desaturase activities can be altered in different metabolic conditions, but the adiposity-independent associations with clinical and biochemical indicators of cardiometabolic risk are still unclear. This study aimed to analyze the associations of FAs composition and estimated desaturase activities with anthropometric, clinical, and biochemical cardiometabolic risk indicators in non-diabetic Serbian women, and to investigate if these associations were independent of the level of adiposity and other confounders.

Methods: In 76 non-diabetic, otherwise healthy Serbian women, aged 24-68 years, with or without metabolic syndrome or obesity (BMI=23.6±5.6 kg/m2), FA composition in erythrocyte phospholipids was measured by gas-liquid chromatography. Desaturase activities were estimated from product/precursor FAs ratios (D9D:16:1n-7/16:0; D6D:20:3n-6/18:2n-6; D5D:20:4n-6/20:3n-6). Correlations were made with anthropometric, biochemical (serum glucose, triacylglycerols, LDL-C, HDL-C, ALT, AST, and their ratios) and clinical (blood pressure) indicators of cardiometabolic risk. Linear regression models were performed to test the independence of these associations.

Results: Estimated desaturase activities and certain FAs were associated with anthropometric, clinical and biochemical indicators of cardiometabolic risk: D9D, D6D, 16:1n-7 and 20:3n-6 were directly associated, while D5D and 18:0 were inversely associated. However, the associations with clinical and biochemical indicators were not independent of the associations with the level of adiposity, since they were lost after controlling for anthropometric indices. After controlling for multiple confounders (age, postmenopausal status, education, smoking, physical activity, dietary macronutrient intakes, use of supplements, alcohol consumption), the level of adiposity was the most significant predictor of desaturase activities and aforementioned FAs levels, and mediated their association with biochemical/clinical indicators. Vice versa, desaturase activities predicted the level of adiposity, but not other components of cardiometabolic risk (if the level of adiposity was accounted). While the associations of anthropometric indices with 16:1n-7, 20:3n-6, 18:0 and D9D and D6D activities were linear, the associations with D5D activity were the inverse U-shaped. The only adiposity-independent association of FAs profiles with the indicators of cardiometabolic risk was a positive association of 20:5n-3 with ALT/AST ratio, which requires further exploration.

Discussion: Additional studies are needed to explore the mechanisms of the observed associations.",
publisher = "Frontiers Media S.A.",
journal = "Frontiers in Nutrition",
title = "Associations of fatty acids composition and estimated desaturase activities in erythrocyte phospholipids with biochemical and clinical indicators of cardiometabolic risk in non-diabetic Serbian women: the role of level of adiposity",
volume = "10",
doi = "10.3389/fnut.2023.1065578",
url = "https://hdl.handle.net/21.15107/rcub_rimi_1345"
}

Šarac, I., Debeljak-Martačić, J., Takić, M., Stevanović, V., Milešević, J., Zeković, M., Popović, T. B., Jovanović, J.,& Kardum Vidović, N.. (2023). Associations of fatty acids composition and estimated desaturase activities in erythrocyte phospholipids with biochemical and clinical indicators of cardiometabolic risk in non-diabetic Serbian women: the role of level of adiposity. in Frontiers in Nutrition
Frontiers Media S.A.., 10.
https://doi.org/10.3389/fnut.2023.1065578
https://hdl.handle.net/21.15107/rcub_rimi_1345

Šarac I, Debeljak-Martačić J, Takić M, Stevanović V, Milešević J, Zeković M, Popović TB, Jovanović J, Kardum Vidović N. Associations of fatty acids composition and estimated desaturase activities in erythrocyte phospholipids with biochemical and clinical indicators of cardiometabolic risk in non-diabetic Serbian women: the role of level of adiposity. in Frontiers in Nutrition. 2023;10.
doi:10.3389/fnut.2023.1065578
https://hdl.handle.net/21.15107/rcub_rimi_1345 .

Šarac, Ivana, Debeljak-Martačić, Jasmina, Takić, Marija, Stevanović, Vuk, Milešević, Jelena, Zeković, Milica, Popović, Tamara B., Jovanović, Jovica, Kardum Vidović, Nevena, "Associations of fatty acids composition and estimated desaturase activities in erythrocyte phospholipids with biochemical and clinical indicators of cardiometabolic risk in non-diabetic Serbian women: the role of level of adiposity" in Frontiers in Nutrition, 10 (2023),
https://doi.org/10.3389/fnut.2023.1065578 .,
https://hdl.handle.net/21.15107/rcub_rimi_1345 .

TY  - JOUR
AU  - Jovanović, Darko
AU  - Aćimović, Miodrag
AU  - Pejčić, Tomislav
AU  - Milojević, Bogomir
AU  - Čegar, Bojan
AU  - Zeković, Milica
AU  - Lisičić, Nikola
AU  - Džamić, Zoran
AU  - Marić, Gorica
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1392
AB  - Background: Penile cancer (PC) is a highly aggressive disease, with a significant tendency for lymphatic spreading and subsequent development of distant metastases. The mutilating nature of PC surgical treatment has profound implications on the patient’s body integrity and self-image, sexual life and intimacy, voiding and mental health. The aim of our study was to comprehensively evaluate PC patients’ post-treatment quality of life (QoL), sexual activity, self-esteem, fatigue and fear of disease recurrence. (2) Methods: A cross-sectional study was conducted at the Clinic of Urology, University Clinical Centre of Serbia, and included 31 PC patients. Data were collected by means of a questionnaire. (3) Results: The average score on the Global health status scale was 67.2 out of 100 (ranging from 16.7 to 100), and the SD was 22.5. Hierarchical linear regression analysis showed that demographic characteristics, Hospital Anxiety and Depression scale (HADS) anxiety and depression scores, total Multidimensional Fatigue Inventory, Fear of cancer recurrence and Rosenberg scores and erectile function score explained a total of 78.2% of the variance in the global health status/QoL scale of PC patients. (4) Conclusions: Efforts should be made not only to increase the survival of PC patients after surgical treatment but also to enable the best possible level of QoL in the post-operative period.
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Healthcare
T2  - Healthcare
T1  - Comprehensive Evaluation of Quality of Life in Penile Cancer Patients following Surgical Treatment
IS  - 23
SP  - 3091
VL  - 11
DO  - 10.3390/healthcare11233091
ER  - 

@article{
author = "Jovanović, Darko and Aćimović, Miodrag and Pejčić, Tomislav and Milojević, Bogomir and Čegar, Bojan and Zeković, Milica and Lisičić, Nikola and Džamić, Zoran and Marić, Gorica",
year = "2023",
abstract = "Background: Penile cancer (PC) is a highly aggressive disease, with a significant tendency for lymphatic spreading and subsequent development of distant metastases. The mutilating nature of PC surgical treatment has profound implications on the patient’s body integrity and self-image, sexual life and intimacy, voiding and mental health. The aim of our study was to comprehensively evaluate PC patients’ post-treatment quality of life (QoL), sexual activity, self-esteem, fatigue and fear of disease recurrence. (2) Methods: A cross-sectional study was conducted at the Clinic of Urology, University Clinical Centre of Serbia, and included 31 PC patients. Data were collected by means of a questionnaire. (3) Results: The average score on the Global health status scale was 67.2 out of 100 (ranging from 16.7 to 100), and the SD was 22.5. Hierarchical linear regression analysis showed that demographic characteristics, Hospital Anxiety and Depression scale (HADS) anxiety and depression scores, total Multidimensional Fatigue Inventory, Fear of cancer recurrence and Rosenberg scores and erectile function score explained a total of 78.2% of the variance in the global health status/QoL scale of PC patients. (4) Conclusions: Efforts should be made not only to increase the survival of PC patients after surgical treatment but also to enable the best possible level of QoL in the post-operative period.",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Healthcare, Healthcare",
title = "Comprehensive Evaluation of Quality of Life in Penile Cancer Patients following Surgical Treatment",
number = "23",
pages = "3091",
volume = "11",
doi = "10.3390/healthcare11233091"
}

Jovanović, D., Aćimović, M., Pejčić, T., Milojević, B., Čegar, B., Zeković, M., Lisičić, N., Džamić, Z.,& Marić, G.. (2023). Comprehensive Evaluation of Quality of Life in Penile Cancer Patients following Surgical Treatment. in Healthcare
Multidisciplinary Digital Publishing Institute (MDPI)., 11(23), 3091.
https://doi.org/10.3390/healthcare11233091

Jovanović D, Aćimović M, Pejčić T, Milojević B, Čegar B, Zeković M, Lisičić N, Džamić Z, Marić G. Comprehensive Evaluation of Quality of Life in Penile Cancer Patients following Surgical Treatment. in Healthcare. 2023;11(23):3091.
doi:10.3390/healthcare11233091 .

Jovanović, Darko, Aćimović, Miodrag, Pejčić, Tomislav, Milojević, Bogomir, Čegar, Bojan, Zeković, Milica, Lisičić, Nikola, Džamić, Zoran, Marić, Gorica, "Comprehensive Evaluation of Quality of Life in Penile Cancer Patients following Surgical Treatment" in Healthcare, 11, no. 23 (2023):3091,
https://doi.org/10.3390/healthcare11233091 . .

TY  - JOUR
AU  - Vranić, Danijela
AU  - Milešević, Jelena
AU  - Trbović, Dejana
AU  - Gurinović, Mirjana
AU  - Korićanac, Vladimir
AU  - Zeković, Milica
AU  - Petrović, Zoran
AU  - Ranković, Slavica G.
AU  - Milićević, Dragan
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1307
AB  - Diet during pregnancy is one of the most important nutritional challenges associated with some risks for the mother and the fetus. For the first time, the study aims to estimate long-term (2018–2022) exposure to nitrate and phosphates in Serbian pregnant women, based on individual consumption data and accurate values measured in frequently consumed meat products. For this purpose, seven types of meat products, consisting of 3047 and 1943 samples, were collected from retail markets across Serbia, to analyze nitrites and phosphorus content, respectively. These data were combined with meat product consumption data from the Serbian National Food Consumption Survey to assess dietary intake of nitrites and phosphate. The results were compared with the acceptable daily intake (ADI) proposed by the European Food Safety Authority. The average dietary exposure (EDI) to phosphorus ranged from 0.733 mg/kg bw/day (liver sausage and pate) to 2.441 mg/kg bw/day (finely minced cooked sausages). Considering nitrite intake, the major sources were bacon (0.030 mg/kg bw/day) and coarsely minced cooked sausages (0.0189 mg/kg bw/day). In our study, average nitrite and phosphorus exposure in the Serbian pregnant women population are far below the EFSA recommendations (ADI 0.07 mg/kg bw/day and 40 mg/kg bw/day, respectively).
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Nutrients
T1  - Exposure to Phosphates and Nitrites through Meat Products: Estimation of the Potential Risk to Pregnant Women
IS  - 12
SP  - 2777
VL  - 15
DO  - 10.3390/nu15122777
ER  - 

@article{
author = "Vranić, Danijela and Milešević, Jelena and Trbović, Dejana and Gurinović, Mirjana and Korićanac, Vladimir and Zeković, Milica and Petrović, Zoran and Ranković, Slavica G. and Milićević, Dragan",
year = "2023",
abstract = "Diet during pregnancy is one of the most important nutritional challenges associated with some risks for the mother and the fetus. For the first time, the study aims to estimate long-term (2018–2022) exposure to nitrate and phosphates in Serbian pregnant women, based on individual consumption data and accurate values measured in frequently consumed meat products. For this purpose, seven types of meat products, consisting of 3047 and 1943 samples, were collected from retail markets across Serbia, to analyze nitrites and phosphorus content, respectively. These data were combined with meat product consumption data from the Serbian National Food Consumption Survey to assess dietary intake of nitrites and phosphate. The results were compared with the acceptable daily intake (ADI) proposed by the European Food Safety Authority. The average dietary exposure (EDI) to phosphorus ranged from 0.733 mg/kg bw/day (liver sausage and pate) to 2.441 mg/kg bw/day (finely minced cooked sausages). Considering nitrite intake, the major sources were bacon (0.030 mg/kg bw/day) and coarsely minced cooked sausages (0.0189 mg/kg bw/day). In our study, average nitrite and phosphorus exposure in the Serbian pregnant women population are far below the EFSA recommendations (ADI 0.07 mg/kg bw/day and 40 mg/kg bw/day, respectively).",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Nutrients",
title = "Exposure to Phosphates and Nitrites through Meat Products: Estimation of the Potential Risk to Pregnant Women",
number = "12",
pages = "2777",
volume = "15",
doi = "10.3390/nu15122777"
}

Vranić, D., Milešević, J., Trbović, D., Gurinović, M., Korićanac, V., Zeković, M., Petrović, Z., Ranković, S. G.,& Milićević, D.. (2023). Exposure to Phosphates and Nitrites through Meat Products: Estimation of the Potential Risk to Pregnant Women. in Nutrients
Multidisciplinary Digital Publishing Institute (MDPI)., 15(12), 2777.
https://doi.org/10.3390/nu15122777

Vranić D, Milešević J, Trbović D, Gurinović M, Korićanac V, Zeković M, Petrović Z, Ranković SG, Milićević D. Exposure to Phosphates and Nitrites through Meat Products: Estimation of the Potential Risk to Pregnant Women. in Nutrients. 2023;15(12):2777.
doi:10.3390/nu15122777 .

Vranić, Danijela, Milešević, Jelena, Trbović, Dejana, Gurinović, Mirjana, Korićanac, Vladimir, Zeković, Milica, Petrović, Zoran, Ranković, Slavica G., Milićević, Dragan, "Exposure to Phosphates and Nitrites through Meat Products: Estimation of the Potential Risk to Pregnant Women" in Nutrients, 15, no. 12 (2023):2777,
https://doi.org/10.3390/nu15122777 . .

TY  - JOUR
AU  - Milešević, Jelena
AU  - Lilić, Slobodan
AU  - Vranić, Danijela
AU  - Zeković, Milica
AU  - Borović, Branka
AU  - Glibetić, Marija
AU  - Gurinović, Mirjana
AU  - Milićević, Dragan
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1280
AB  - Salt intake above 5 g/day correlates with prevalence of hypertension and cardiovascular diseases (CVD). CVD, the leading cause of mortality and morbidity in Europe, account for 45% of all deaths, while, in Serbia in 2021, CVD accounted for 47.3%. The objective was to investigate salt content labelled on meat products from the Serbian market and estimate dietary exposure to salt from meat products in the Serbian population using consumption data. Data on salt content were collected from 339 meat products and classified in eight groups. Consumption data were collected using the EFSA EU Menu methodology (2017–2021) from 576 children and 3018 adults (145 pregnant women) in four geographical regions of Serbia. The highest salt content was in dry fermented sausages and dry meat, average 3.78 ± 0.37 g/100 g and 4.40 ± 1.21 g/100 g, respectively. The average intake of meat products is 45.21 ± 39.0 g/day and estimated daily salt intake from meat products per person is 1.192 g, which is 24% of the daily recommended amount. The actual meat product consumption and content of salt in meat products in Serbia present a risk factor for development of CVD and related comorbidities. A targeted strategy, policy and legislation for salt reduction are needed.
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
T2  - International Journal of Environmental Research and Public Health
T1  - Dietary Intake of Salt from Meat Products in Serbian Population
IS  - 5
SP  - 4192
VL  - 20
DO  - 10.3390/ijerph20054192
ER  - 

@article{
author = "Milešević, Jelena and Lilić, Slobodan and Vranić, Danijela and Zeković, Milica and Borović, Branka and Glibetić, Marija and Gurinović, Mirjana and Milićević, Dragan",
year = "2023",
abstract = "Salt intake above 5 g/day correlates with prevalence of hypertension and cardiovascular diseases (CVD). CVD, the leading cause of mortality and morbidity in Europe, account for 45% of all deaths, while, in Serbia in 2021, CVD accounted for 47.3%. The objective was to investigate salt content labelled on meat products from the Serbian market and estimate dietary exposure to salt from meat products in the Serbian population using consumption data. Data on salt content were collected from 339 meat products and classified in eight groups. Consumption data were collected using the EFSA EU Menu methodology (2017–2021) from 576 children and 3018 adults (145 pregnant women) in four geographical regions of Serbia. The highest salt content was in dry fermented sausages and dry meat, average 3.78 ± 0.37 g/100 g and 4.40 ± 1.21 g/100 g, respectively. The average intake of meat products is 45.21 ± 39.0 g/day and estimated daily salt intake from meat products per person is 1.192 g, which is 24% of the daily recommended amount. The actual meat product consumption and content of salt in meat products in Serbia present a risk factor for development of CVD and related comorbidities. A targeted strategy, policy and legislation for salt reduction are needed.",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "International Journal of Environmental Research and Public Health",
title = "Dietary Intake of Salt from Meat Products in Serbian Population",
number = "5",
pages = "4192",
volume = "20",
doi = "10.3390/ijerph20054192"
}

Milešević, J., Lilić, S., Vranić, D., Zeković, M., Borović, B., Glibetić, M., Gurinović, M.,& Milićević, D.. (2023). Dietary Intake of Salt from Meat Products in Serbian Population. in International Journal of Environmental Research and Public Health
Multidisciplinary Digital Publishing Institute (MDPI)., 20(5), 4192.
https://doi.org/10.3390/ijerph20054192

Milešević J, Lilić S, Vranić D, Zeković M, Borović B, Glibetić M, Gurinović M, Milićević D. Dietary Intake of Salt from Meat Products in Serbian Population. in International Journal of Environmental Research and Public Health. 2023;20(5):4192.
doi:10.3390/ijerph20054192 .

Milešević, Jelena, Lilić, Slobodan, Vranić, Danijela, Zeković, Milica, Borović, Branka, Glibetić, Marija, Gurinović, Mirjana, Milićević, Dragan, "Dietary Intake of Salt from Meat Products in Serbian Population" in International Journal of Environmental Research and Public Health, 20, no. 5 (2023):4192,
https://doi.org/10.3390/ijerph20054192 . .

TY  - JOUR
AU  - Pejčić, Tomislav
AU  - Zeković, Milica
AU  - Bumbaširević, Uroš
AU  - Kalaba, Milica
AU  - Vovk, Irena
AU  - Bensa, Maja
AU  - Popović, Lazar
AU  - Tešić, Živoslav
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1278
AB  - This narrative review summarizes epidemiological studies on breast cancer and prostate cancer with an overview of their global incidence distribution to investigate the relationship between these diseases and diet. The biological properties, mechanisms of action, and available data supporting the potential role of isoflavones in the prevention of breast cancer and prostate cancer are discussed. Studies evaluating the effects of isoflavones in tissue cultures of normal and malignant breast and prostate cells, as well as the current body of research regarding the effects of isoflavones attained through multiple modifications of cellular molecular signaling pathways and control of oxidative stress, are summarized. Furthermore, this review compiles literature sources reporting on the following: (1) levels of estrogen in breast and prostate tissue; (2) levels of isoflavones in the normal and malignant tissue of these organs in European and Asian populations; (3) average concentrations of isoflavones in the secretion of these organs (milk and semen). Finally, particular emphasis is placed on studies investigating the effect of isoflavones on tissues via estrogen receptors (ER).
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Antioxidants
T1  - The Role of Isoflavones in the Prevention of Breast Cancer and Prostate Cancer
IS  - 2
SP  - 368
VL  - 12
DO  - 10.3390/antiox12020368
ER  - 

@article{
author = "Pejčić, Tomislav and Zeković, Milica and Bumbaširević, Uroš and Kalaba, Milica and Vovk, Irena and Bensa, Maja and Popović, Lazar and Tešić, Živoslav",
year = "2023",
abstract = "This narrative review summarizes epidemiological studies on breast cancer and prostate cancer with an overview of their global incidence distribution to investigate the relationship between these diseases and diet. The biological properties, mechanisms of action, and available data supporting the potential role of isoflavones in the prevention of breast cancer and prostate cancer are discussed. Studies evaluating the effects of isoflavones in tissue cultures of normal and malignant breast and prostate cells, as well as the current body of research regarding the effects of isoflavones attained through multiple modifications of cellular molecular signaling pathways and control of oxidative stress, are summarized. Furthermore, this review compiles literature sources reporting on the following: (1) levels of estrogen in breast and prostate tissue; (2) levels of isoflavones in the normal and malignant tissue of these organs in European and Asian populations; (3) average concentrations of isoflavones in the secretion of these organs (milk and semen). Finally, particular emphasis is placed on studies investigating the effect of isoflavones on tissues via estrogen receptors (ER).",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Antioxidants",
title = "The Role of Isoflavones in the Prevention of Breast Cancer and Prostate Cancer",
number = "2",
pages = "368",
volume = "12",
doi = "10.3390/antiox12020368"
}

Pejčić, T., Zeković, M., Bumbaširević, U., Kalaba, M., Vovk, I., Bensa, M., Popović, L.,& Tešić, Ž.. (2023). The Role of Isoflavones in the Prevention of Breast Cancer and Prostate Cancer. in Antioxidants
Multidisciplinary Digital Publishing Institute (MDPI)., 12(2), 368.
https://doi.org/10.3390/antiox12020368

Pejčić T, Zeković M, Bumbaširević U, Kalaba M, Vovk I, Bensa M, Popović L, Tešić Ž. The Role of Isoflavones in the Prevention of Breast Cancer and Prostate Cancer. in Antioxidants. 2023;12(2):368.
doi:10.3390/antiox12020368 .

Pejčić, Tomislav, Zeković, Milica, Bumbaširević, Uroš, Kalaba, Milica, Vovk, Irena, Bensa, Maja, Popović, Lazar, Tešić, Živoslav, "The Role of Isoflavones in the Prevention of Breast Cancer and Prostate Cancer" in Antioxidants, 12, no. 2 (2023):368,
https://doi.org/10.3390/antiox12020368 . .

TY  - JOUR
AU  - Zeković, Milica
AU  - Bumbaširević, Uroš
AU  - Živković, Marko
AU  - Pejčić, Tomislav
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1282
AB  - Cancer is increasingly recognized as an extraordinarily heterogeneous disease featuring an intricate mutational landscape and vast intra- and intertumor variability on both genetic and phenotypic levels. Prostate cancer (PCa) is the second most prevalent malignant disease among men worldwide. A single metabolic program cannot epitomize the perplexing reprogramming of tumor metabolism needed to sustain the stemness of neoplastic cells and their prominent energy-consuming functional properties, such as intensive proliferation, uncontrolled growth, migration, and invasion. In cancerous tissue, lipids provide the structural integrity of biological membranes, supply energy, influence the regulation of redox homeostasis, contribute to plasticity, angiogenesis and microenvironment reshaping, mediate the modulation of the inflammatory response, and operate as signaling messengers, i.e., lipid mediators affecting myriad processes relevant for the development of the neoplasia. Comprehensive elucidation of the lipid metabolism alterations in PCa, the underlying regulatory mechanisms, and their implications in tumorigenesis and the progression of the disease are gaining growing research interest in the contemporary urologic oncology. Delineation of the unique metabolic signature of the PCa featuring major aberrant pathways including de novo lipogenesis, lipid uptake, storage and compositional reprogramming may provide novel, exciting, and promising avenues for improving diagnosis, risk stratification, and clinical management of such a complex and heterogeneous pathology.
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
T2  - International Journal of Molecular Sciences
T1  - Alteration of Lipid Metabolism in Prostate Cancer: Multifaceted Oncologic Implications
IS  - 2
SP  - 1391
VL  - 24
DO  - 10.3390/ijms24021391
ER  - 

@article{
author = "Zeković, Milica and Bumbaširević, Uroš and Živković, Marko and Pejčić, Tomislav",
year = "2023",
abstract = "Cancer is increasingly recognized as an extraordinarily heterogeneous disease featuring an intricate mutational landscape and vast intra- and intertumor variability on both genetic and phenotypic levels. Prostate cancer (PCa) is the second most prevalent malignant disease among men worldwide. A single metabolic program cannot epitomize the perplexing reprogramming of tumor metabolism needed to sustain the stemness of neoplastic cells and their prominent energy-consuming functional properties, such as intensive proliferation, uncontrolled growth, migration, and invasion. In cancerous tissue, lipids provide the structural integrity of biological membranes, supply energy, influence the regulation of redox homeostasis, contribute to plasticity, angiogenesis and microenvironment reshaping, mediate the modulation of the inflammatory response, and operate as signaling messengers, i.e., lipid mediators affecting myriad processes relevant for the development of the neoplasia. Comprehensive elucidation of the lipid metabolism alterations in PCa, the underlying regulatory mechanisms, and their implications in tumorigenesis and the progression of the disease are gaining growing research interest in the contemporary urologic oncology. Delineation of the unique metabolic signature of the PCa featuring major aberrant pathways including de novo lipogenesis, lipid uptake, storage and compositional reprogramming may provide novel, exciting, and promising avenues for improving diagnosis, risk stratification, and clinical management of such a complex and heterogeneous pathology.",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "International Journal of Molecular Sciences",
title = "Alteration of Lipid Metabolism in Prostate Cancer: Multifaceted Oncologic Implications",
number = "2",
pages = "1391",
volume = "24",
doi = "10.3390/ijms24021391"
}

Zeković, M., Bumbaširević, U., Živković, M.,& Pejčić, T.. (2023). Alteration of Lipid Metabolism in Prostate Cancer: Multifaceted Oncologic Implications. in International Journal of Molecular Sciences
Multidisciplinary Digital Publishing Institute (MDPI)., 24(2), 1391.
https://doi.org/10.3390/ijms24021391

Zeković M, Bumbaširević U, Živković M, Pejčić T. Alteration of Lipid Metabolism in Prostate Cancer: Multifaceted Oncologic Implications. in International Journal of Molecular Sciences. 2023;24(2):1391.
doi:10.3390/ijms24021391 .

Zeković, Milica, Bumbaširević, Uroš, Živković, Marko, Pejčić, Tomislav, "Alteration of Lipid Metabolism in Prostate Cancer: Multifaceted Oncologic Implications" in International Journal of Molecular Sciences, 24, no. 2 (2023):1391,
https://doi.org/10.3390/ijms24021391 . .

TY  - JOUR
AU  - Bumbaširević, Uroš
AU  - Bojanić, Nebojša
AU  - Plješa-Ercegovac, Marija S.
AU  - Živković, Marko
AU  - Đukić, Tatjana I.
AU  - Zeković, Milica
AU  - Milojević, Bogomir
AU  - Kajmaković, Boris
AU  - Janičić, Aleksandar
AU  - Simić, Tatjana
AU  - Ćorić, Vesna
PY  - 2022
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1209
AB  - The simultaneous analysis of redox biomarkers and polymorphisms encoding for regulatory and catalytic antioxidant proteins was performed in order to evaluate their potential role in the development of testicular germ cell tumor (GCT), as well as the progression of the disease. NRF2 (rs6721961), GSTM3 (rs1332018), SOD2 (rs4880) and GPX3 (rs8177412) polymorphisms were assessed in 88 patients with testicular GCT (52 with seminoma) and 88 age-matched controls. The plasma levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG), thiol groups and the plasma activity of glutathione peroxidase were measured. A significant association between variant GPX3*TC+CC genotype and risk of overall testicular GCT, as well as seminoma development, was found. Moreover, carriers of variant SOD2*TT genotype were at almost 3-fold increased risk of seminoma development. Interestingly, combined SOD2*TT/GPX3*TC+CC genotype conferred a 7-fold higher risk for testicular GCT development. Finally, variant GSTM3*AC+CC genotype was associated with a higher risk for the development of advanced diseased. The presence of assessed genetic variants was not associated with significantly higher levels of redox biomarkers in both testicular GCT patients, as well as in those diagnosed with seminoma. In conclusion, the polymorphic expression of certain antioxidant enzymes might affect susceptibility toward testicular GCT development, as well as the progression of the disease.
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Cancers
T1  - The Polymorphisms of Genes Encoding Catalytic Antioxidant Proteins Modulate the Susceptibility and Progression of Testicular Germ Cell Tumor
IS  - 4
SP  - 1068
VL  - 14
DO  - 10.3390/cancers14041068
ER  - 

@article{
author = "Bumbaširević, Uroš and Bojanić, Nebojša and Plješa-Ercegovac, Marija S. and Živković, Marko and Đukić, Tatjana I. and Zeković, Milica and Milojević, Bogomir and Kajmaković, Boris and Janičić, Aleksandar and Simić, Tatjana and Ćorić, Vesna",
year = "2022",
abstract = "The simultaneous analysis of redox biomarkers and polymorphisms encoding for regulatory and catalytic antioxidant proteins was performed in order to evaluate their potential role in the development of testicular germ cell tumor (GCT), as well as the progression of the disease. NRF2 (rs6721961), GSTM3 (rs1332018), SOD2 (rs4880) and GPX3 (rs8177412) polymorphisms were assessed in 88 patients with testicular GCT (52 with seminoma) and 88 age-matched controls. The plasma levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG), thiol groups and the plasma activity of glutathione peroxidase were measured. A significant association between variant GPX3*TC+CC genotype and risk of overall testicular GCT, as well as seminoma development, was found. Moreover, carriers of variant SOD2*TT genotype were at almost 3-fold increased risk of seminoma development. Interestingly, combined SOD2*TT/GPX3*TC+CC genotype conferred a 7-fold higher risk for testicular GCT development. Finally, variant GSTM3*AC+CC genotype was associated with a higher risk for the development of advanced diseased. The presence of assessed genetic variants was not associated with significantly higher levels of redox biomarkers in both testicular GCT patients, as well as in those diagnosed with seminoma. In conclusion, the polymorphic expression of certain antioxidant enzymes might affect susceptibility toward testicular GCT development, as well as the progression of the disease.",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Cancers",
title = "The Polymorphisms of Genes Encoding Catalytic Antioxidant Proteins Modulate the Susceptibility and Progression of Testicular Germ Cell Tumor",
number = "4",
pages = "1068",
volume = "14",
doi = "10.3390/cancers14041068"
}

Bumbaširević, U., Bojanić, N., Plješa-Ercegovac, M. S., Živković, M., Đukić, T. I., Zeković, M., Milojević, B., Kajmaković, B., Janičić, A., Simić, T.,& Ćorić, V.. (2022). The Polymorphisms of Genes Encoding Catalytic Antioxidant Proteins Modulate the Susceptibility and Progression of Testicular Germ Cell Tumor. in Cancers
Multidisciplinary Digital Publishing Institute (MDPI)., 14(4), 1068.
https://doi.org/10.3390/cancers14041068

Bumbaširević U, Bojanić N, Plješa-Ercegovac MS, Živković M, Đukić TI, Zeković M, Milojević B, Kajmaković B, Janičić A, Simić T, Ćorić V. The Polymorphisms of Genes Encoding Catalytic Antioxidant Proteins Modulate the Susceptibility and Progression of Testicular Germ Cell Tumor. in Cancers. 2022;14(4):1068.
doi:10.3390/cancers14041068 .

Bumbaširević, Uroš, Bojanić, Nebojša, Plješa-Ercegovac, Marija S., Živković, Marko, Đukić, Tatjana I., Zeković, Milica, Milojević, Bogomir, Kajmaković, Boris, Janičić, Aleksandar, Simić, Tatjana, Ćorić, Vesna, "The Polymorphisms of Genes Encoding Catalytic Antioxidant Proteins Modulate the Susceptibility and Progression of Testicular Germ Cell Tumor" in Cancers, 14, no. 4 (2022):1068,
https://doi.org/10.3390/cancers14041068 . .

TY  - JOUR
AU  - Bumbaširević, Uroš
AU  - Bojanić, Nebojša
AU  - Simić, Tatjana
AU  - Milojević, Bogomir
AU  - Živković, Marko
AU  - Kosanović, Tijana
AU  - Kajmaković, Boris
AU  - Janičić, Aleksandar
AU  - Durutović, Otaš
AU  - Radovanović, Milan
AU  - Šantrić, Veljko
AU  - Zeković, Milica
AU  - Ćorić, Vesna
PY  - 2022
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1239
AB  - Sustained and dysregulated inflammation, concurrent tumor-induced immune suppression, and oxidative stress are profoundly involved in cancer initiation, presentation, and perpetuation. Within this prospective study, we simultaneously analyzed the preoperative indices of systemic inflammatory response and the representative byproducts of oxidative DNA, protein, and lipid damage with the aim of evaluating their clinical relevance among patients diagnosed with testicular germ-cell tumors (GCT). In the analytical cohort (n = 88, median age 34 years), neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (dNLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and C-reactive protein (CRP) were significantly altered in patients with a higher tumor stage (p < 0.05). Highly suggestive correlations were found between NLR, dNLR, and SII and modified nucleoside 8-OHdG. CRP and albumin-to-globulin ratio (AGR) significantly correlated with thiols group level and maximal tumor dimension (p < 0.05). Based on receiver operating characteristic (ROC) curve analyses, all the evaluated pre-orchiectomy inflammation markers demonstrated strong performance in predicting metastatic disease; optimal cut-off points were determined for each indicator. Although further large-scale studies are warranted, inflammatory and redox indices may both complement the established tumor markers and standard clinicopathological prognostic variables and contribute to enhanced personalized risk-assessment among testicular GCT patients.
T2  - Journal of Personalized Medicine
T1  - Interplay between Comprehensive Inflammation Indices and Redox Biomarkers in Testicular Germ-Cell Tumors
IS  - 5
SP  - 833
VL  - 12
DO  - 10.3390/jpm12050833
ER  - 

@article{
author = "Bumbaširević, Uroš and Bojanić, Nebojša and Simić, Tatjana and Milojević, Bogomir and Živković, Marko and Kosanović, Tijana and Kajmaković, Boris and Janičić, Aleksandar and Durutović, Otaš and Radovanović, Milan and Šantrić, Veljko and Zeković, Milica and Ćorić, Vesna",
year = "2022",
abstract = "Sustained and dysregulated inflammation, concurrent tumor-induced immune suppression, and oxidative stress are profoundly involved in cancer initiation, presentation, and perpetuation. Within this prospective study, we simultaneously analyzed the preoperative indices of systemic inflammatory response and the representative byproducts of oxidative DNA, protein, and lipid damage with the aim of evaluating their clinical relevance among patients diagnosed with testicular germ-cell tumors (GCT). In the analytical cohort (n = 88, median age 34 years), neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (dNLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and C-reactive protein (CRP) were significantly altered in patients with a higher tumor stage (p < 0.05). Highly suggestive correlations were found between NLR, dNLR, and SII and modified nucleoside 8-OHdG. CRP and albumin-to-globulin ratio (AGR) significantly correlated with thiols group level and maximal tumor dimension (p < 0.05). Based on receiver operating characteristic (ROC) curve analyses, all the evaluated pre-orchiectomy inflammation markers demonstrated strong performance in predicting metastatic disease; optimal cut-off points were determined for each indicator. Although further large-scale studies are warranted, inflammatory and redox indices may both complement the established tumor markers and standard clinicopathological prognostic variables and contribute to enhanced personalized risk-assessment among testicular GCT patients.",
journal = "Journal of Personalized Medicine",
title = "Interplay between Comprehensive Inflammation Indices and Redox Biomarkers in Testicular Germ-Cell Tumors",
number = "5",
pages = "833",
volume = "12",
doi = "10.3390/jpm12050833"
}

Bumbaširević, U., Bojanić, N., Simić, T., Milojević, B., Živković, M., Kosanović, T., Kajmaković, B., Janičić, A., Durutović, O., Radovanović, M., Šantrić, V., Zeković, M.,& Ćorić, V.. (2022). Interplay between Comprehensive Inflammation Indices and Redox Biomarkers in Testicular Germ-Cell Tumors. in Journal of Personalized Medicine, 12(5), 833.
https://doi.org/10.3390/jpm12050833

Bumbaširević U, Bojanić N, Simić T, Milojević B, Živković M, Kosanović T, Kajmaković B, Janičić A, Durutović O, Radovanović M, Šantrić V, Zeković M, Ćorić V. Interplay between Comprehensive Inflammation Indices and Redox Biomarkers in Testicular Germ-Cell Tumors. in Journal of Personalized Medicine. 2022;12(5):833.
doi:10.3390/jpm12050833 .

Bumbaširević, Uroš, Bojanić, Nebojša, Simić, Tatjana, Milojević, Bogomir, Živković, Marko, Kosanović, Tijana, Kajmaković, Boris, Janičić, Aleksandar, Durutović, Otaš, Radovanović, Milan, Šantrić, Veljko, Zeković, Milica, Ćorić, Vesna, "Interplay between Comprehensive Inflammation Indices and Redox Biomarkers in Testicular Germ-Cell Tumors" in Journal of Personalized Medicine, 12, no. 5 (2022):833,
https://doi.org/10.3390/jpm12050833 . .

TY  - JOUR
AU  - Milešević, Jelena
AU  - Vranić, Danijela
AU  - Gurinović, Mirjana
AU  - Korićanac, Vladimir
AU  - Borović, Branka
AU  - Zeković, Milica
AU  - Šarac, Ivana
AU  - Milićević, Dragan R.
AU  - Glibetić, Marija
PY  - 2022
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1185
AB  - This study provides the data on dietary exposure of Serbian children to nitrites and phosphorus from meat products by combining individual consumption data with available analytical data of meat products. A total of 2603 and 1900 commercially available meat products were categorized into seven groups and analysed for nitrite and phosphorous content. The highest mean levels of nitrite content, expressed as NaNO2, were found in finely minced cooked sausages (40.25 ± 20.37 mg/kg), followed by canned meat (34.95 ± 22.12 mg/kg) and coarsely minced cooked sausages (32.85 ± 23.25 mg/kg). The EDI (estimated daily intake) of nitrites from meat products, calculated from a National Food Consumption Survey in 576 children aged 1–9 years, indicated that the Serbian children population exceeded the nitrite ADI (acceptable daily intake) proposed by EFSA (European Food Safety Authority) in 6.4% of children, with a higher proportion in 1–3-year-old participants. The mean phosphorus concentration varied from 2.71 ± 1.05 g/kg to 6.12 ± 1.33 g/kg in liver sausage and pate and smoked meat products, respectively. The EDI of phosphorus from meat products was far below the ADI proposed by EFSA, indicating that the use of phosphorus additives in Serbian meat products is generally in line with legislation.
PB  - MDPI
T2  - Nutrients
T1  - The Intake of Phosphorus and Nitrites through Meat Products: A Health Risk Assessment of Children Aged 1 to 9 Years Old in Serbia
IS  - 2
SP  - 242
VL  - 14
DO  - 10.3390/nu14020242
ER  - 

@article{
author = "Milešević, Jelena and Vranić, Danijela and Gurinović, Mirjana and Korićanac, Vladimir and Borović, Branka and Zeković, Milica and Šarac, Ivana and Milićević, Dragan R. and Glibetić, Marija",
year = "2022",
abstract = "This study provides the data on dietary exposure of Serbian children to nitrites and phosphorus from meat products by combining individual consumption data with available analytical data of meat products. A total of 2603 and 1900 commercially available meat products were categorized into seven groups and analysed for nitrite and phosphorous content. The highest mean levels of nitrite content, expressed as NaNO2, were found in finely minced cooked sausages (40.25 ± 20.37 mg/kg), followed by canned meat (34.95 ± 22.12 mg/kg) and coarsely minced cooked sausages (32.85 ± 23.25 mg/kg). The EDI (estimated daily intake) of nitrites from meat products, calculated from a National Food Consumption Survey in 576 children aged 1–9 years, indicated that the Serbian children population exceeded the nitrite ADI (acceptable daily intake) proposed by EFSA (European Food Safety Authority) in 6.4% of children, with a higher proportion in 1–3-year-old participants. The mean phosphorus concentration varied from 2.71 ± 1.05 g/kg to 6.12 ± 1.33 g/kg in liver sausage and pate and smoked meat products, respectively. The EDI of phosphorus from meat products was far below the ADI proposed by EFSA, indicating that the use of phosphorus additives in Serbian meat products is generally in line with legislation.",
publisher = "MDPI",
journal = "Nutrients",
title = "The Intake of Phosphorus and Nitrites through Meat Products: A Health Risk Assessment of Children Aged 1 to 9 Years Old in Serbia",
number = "2",
pages = "242",
volume = "14",
doi = "10.3390/nu14020242"
}

Milešević, J., Vranić, D., Gurinović, M., Korićanac, V., Borović, B., Zeković, M., Šarac, I., Milićević, D. R.,& Glibetić, M.. (2022). The Intake of Phosphorus and Nitrites through Meat Products: A Health Risk Assessment of Children Aged 1 to 9 Years Old in Serbia. in Nutrients
MDPI., 14(2), 242.
https://doi.org/10.3390/nu14020242

Milešević J, Vranić D, Gurinović M, Korićanac V, Borović B, Zeković M, Šarac I, Milićević DR, Glibetić M. The Intake of Phosphorus and Nitrites through Meat Products: A Health Risk Assessment of Children Aged 1 to 9 Years Old in Serbia. in Nutrients. 2022;14(2):242.
doi:10.3390/nu14020242 .

Milešević, Jelena, Vranić, Danijela, Gurinović, Mirjana, Korićanac, Vladimir, Borović, Branka, Zeković, Milica, Šarac, Ivana, Milićević, Dragan R., Glibetić, Marija, "The Intake of Phosphorus and Nitrites through Meat Products: A Health Risk Assessment of Children Aged 1 to 9 Years Old in Serbia" in Nutrients, 14, no. 2 (2022):242,
https://doi.org/10.3390/nu14020242 . .

TY  - JOUR
AU  - Gurinović, Mirjana
AU  - Nikolić, Marina
AU  - Zeković, Milica
AU  - Milešević, Jelena
AU  - Kadvan, Agnes
AU  - Ranić, Marija M.
AU  - Glibetić, Marija
PY  - 2022
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1208
AB  - Initiatives in the Capacity Development in Nutrition Research in the Balkan region in the last decade have been toward the creation of contemporary, harmonized Research Infrastructure (RI) compliant with European standards. This study describes the process of creation and implementation of the European Food Safety Authority (EFSA) EU Menu methodology in the Balkan region during the EFSA support projects for food consumption data collection in four countries (Serbia, Montenegro, Bosnia and Herzegovina, and North Macedonia). This process entailed the application and improvement of an innovative tool, the DIET ASSESS and PLAN (DAP), a platform for standardized food consumption data collection and dietary intake assessment. DAP comprises computerized food consumption, anthropometric measurements, and physical activity questionnaires, validated food picture book, and FoodEx2 exposure hierarchy with sets of facet descriptors of the interest. It hosts the Balkan food platform with a Serbian food composition database (FCDB) and Regional FCDB, compliant with European Food Information Resource (EuroFIR™) standards. The implementation of the DAP platform in national dietary surveys conducted with the support of the EFSA EU Menu project in Balkan countries enabled harmonized food consumption data compilation and reporting. Application of the methodology entailed the development of study protocol and extensive education and training of study personnel. The entire data collection process was managed by internal and external survey coordinators. A pilot study was conducted to test the entire data collection and control process and was afterward used to make necessary improvements and adjustments to meet EU Menu requirements. Data collected are internationally comparable with food consumption data in other European countries within the framework of the EU Menu program. The existence of such data in the Balkan region will catalyze research activities in emerging topics, such as identification of dietary patterns, the establishment of national nutrient reference values and food-based dietary guidelines (not only in Serbia, but in the whole Balkan region), dietary exposure assessments, the endorsement and evaluation of new food legislations, the environmental and other effects of diet on the food system. The developed and implemented methodology underpins evidence-based policy-making processes lacking in the field of public health nutrition in the region.
PB  - Frontiers Media S.A.
T2  - Frontiers in Nutrition
T1  - Implementation of Harmonized Food Consumption Data Collection in the Balkan Region According to the EFSA EU Menu Methodology Standards
SP  - 809328
VL  - 8
DO  - 10.3389/fnut.2021.809328
ER  - 

@article{
author = "Gurinović, Mirjana and Nikolić, Marina and Zeković, Milica and Milešević, Jelena and Kadvan, Agnes and Ranić, Marija M. and Glibetić, Marija",
year = "2022",
abstract = "Initiatives in the Capacity Development in Nutrition Research in the Balkan region in the last decade have been toward the creation of contemporary, harmonized Research Infrastructure (RI) compliant with European standards. This study describes the process of creation and implementation of the European Food Safety Authority (EFSA) EU Menu methodology in the Balkan region during the EFSA support projects for food consumption data collection in four countries (Serbia, Montenegro, Bosnia and Herzegovina, and North Macedonia). This process entailed the application and improvement of an innovative tool, the DIET ASSESS and PLAN (DAP), a platform for standardized food consumption data collection and dietary intake assessment. DAP comprises computerized food consumption, anthropometric measurements, and physical activity questionnaires, validated food picture book, and FoodEx2 exposure hierarchy with sets of facet descriptors of the interest. It hosts the Balkan food platform with a Serbian food composition database (FCDB) and Regional FCDB, compliant with European Food Information Resource (EuroFIR™) standards. The implementation of the DAP platform in national dietary surveys conducted with the support of the EFSA EU Menu project in Balkan countries enabled harmonized food consumption data compilation and reporting. Application of the methodology entailed the development of study protocol and extensive education and training of study personnel. The entire data collection process was managed by internal and external survey coordinators. A pilot study was conducted to test the entire data collection and control process and was afterward used to make necessary improvements and adjustments to meet EU Menu requirements. Data collected are internationally comparable with food consumption data in other European countries within the framework of the EU Menu program. The existence of such data in the Balkan region will catalyze research activities in emerging topics, such as identification of dietary patterns, the establishment of national nutrient reference values and food-based dietary guidelines (not only in Serbia, but in the whole Balkan region), dietary exposure assessments, the endorsement and evaluation of new food legislations, the environmental and other effects of diet on the food system. The developed and implemented methodology underpins evidence-based policy-making processes lacking in the field of public health nutrition in the region.",
publisher = "Frontiers Media S.A.",
journal = "Frontiers in Nutrition",
title = "Implementation of Harmonized Food Consumption Data Collection in the Balkan Region According to the EFSA EU Menu Methodology Standards",
pages = "809328",
volume = "8",
doi = "10.3389/fnut.2021.809328"
}

Gurinović, M., Nikolić, M., Zeković, M., Milešević, J., Kadvan, A., Ranić, M. M.,& Glibetić, M.. (2022). Implementation of Harmonized Food Consumption Data Collection in the Balkan Region According to the EFSA EU Menu Methodology Standards. in Frontiers in Nutrition
Frontiers Media S.A.., 8, 809328.
https://doi.org/10.3389/fnut.2021.809328

Gurinović M, Nikolić M, Zeković M, Milešević J, Kadvan A, Ranić MM, Glibetić M. Implementation of Harmonized Food Consumption Data Collection in the Balkan Region According to the EFSA EU Menu Methodology Standards. in Frontiers in Nutrition. 2022;8:809328.
doi:10.3389/fnut.2021.809328 .

Gurinović, Mirjana, Nikolić, Marina, Zeković, Milica, Milešević, Jelena, Kadvan, Agnes, Ranić, Marija M., Glibetić, Marija, "Implementation of Harmonized Food Consumption Data Collection in the Balkan Region According to the EFSA EU Menu Methodology Standards" in Frontiers in Nutrition, 8 (2022):809328,
https://doi.org/10.3389/fnut.2021.809328 . .

TY  - JOUR
AU  - Zeković, Milica
AU  - Milešević, Jelena
AU  - Takić, Marija
AU  - Knez, Marija
AU  - Šarac, Ivana
AU  - Kadvan, Agnes
AU  - Gurinović, Mirjana
AU  - Glibetić, Marija
PY  - 2022
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1253
AB  - The Serbian Food Consumption Survey among 1–9-year-old-children was conceptualized and conducted in compliance with the principles, established protocols, and guidelines of the EU Menu project between 2017 and 2021. Valid data were collected for 576 individuals (290 1–3-year-old toddlers and 276 3–9-year-old children). Regardless of age and gender category, the majority (68.80%) of children had normal weights according to the Body Mass Index-for-age classification system. The median daily energy intake was 1406.71 kcal with no differences between the settlement types. The overall median contributions of carbohydrates, protein, and fat to the total energy intake were 47.54%, 14.06%, and 37.88%, respectively. The proportions of the macronutrient intake deviated from the dietary reference values with compliance to the recommendations being particularly poor for fat and fiber. The consumption of energy-dense food groups such as meat and meat products, fat and oil, sugar, and confections was more pronounced among older children. The survey results provide a valuable insight into the nutritional status and dietary habits of toddlers and children 1–9 years old living in Serbia. They may serve as an evidence platform for public health programs, a valuable asset for decision-makers, and a reliable reference to guide nutritional policies, diet monitoring, and interventions targeting this population group in the future.
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Nutrients
T1  - Evaluation of Dietary Intake and Anthropometric Status in 1–9-Year-Old Children Living in Serbia: National Food Consumption Survey according to the EU Menu Methodology
IS  - 15
SP  - 3091
VL  - 14
DO  - 10.3390/nu14153091
ER  - 

@article{
author = "Zeković, Milica and Milešević, Jelena and Takić, Marija and Knez, Marija and Šarac, Ivana and Kadvan, Agnes and Gurinović, Mirjana and Glibetić, Marija",
year = "2022",
abstract = "The Serbian Food Consumption Survey among 1–9-year-old-children was conceptualized and conducted in compliance with the principles, established protocols, and guidelines of the EU Menu project between 2017 and 2021. Valid data were collected for 576 individuals (290 1–3-year-old toddlers and 276 3–9-year-old children). Regardless of age and gender category, the majority (68.80%) of children had normal weights according to the Body Mass Index-for-age classification system. The median daily energy intake was 1406.71 kcal with no differences between the settlement types. The overall median contributions of carbohydrates, protein, and fat to the total energy intake were 47.54%, 14.06%, and 37.88%, respectively. The proportions of the macronutrient intake deviated from the dietary reference values with compliance to the recommendations being particularly poor for fat and fiber. The consumption of energy-dense food groups such as meat and meat products, fat and oil, sugar, and confections was more pronounced among older children. The survey results provide a valuable insight into the nutritional status and dietary habits of toddlers and children 1–9 years old living in Serbia. They may serve as an evidence platform for public health programs, a valuable asset for decision-makers, and a reliable reference to guide nutritional policies, diet monitoring, and interventions targeting this population group in the future.",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Nutrients",
title = "Evaluation of Dietary Intake and Anthropometric Status in 1–9-Year-Old Children Living in Serbia: National Food Consumption Survey according to the EU Menu Methodology",
number = "15",
pages = "3091",
volume = "14",
doi = "10.3390/nu14153091"
}

Zeković, M., Milešević, J., Takić, M., Knez, M., Šarac, I., Kadvan, A., Gurinović, M.,& Glibetić, M.. (2022). Evaluation of Dietary Intake and Anthropometric Status in 1–9-Year-Old Children Living in Serbia: National Food Consumption Survey according to the EU Menu Methodology. in Nutrients
Multidisciplinary Digital Publishing Institute (MDPI)., 14(15), 3091.
https://doi.org/10.3390/nu14153091

Zeković M, Milešević J, Takić M, Knez M, Šarac I, Kadvan A, Gurinović M, Glibetić M. Evaluation of Dietary Intake and Anthropometric Status in 1–9-Year-Old Children Living in Serbia: National Food Consumption Survey according to the EU Menu Methodology. in Nutrients. 2022;14(15):3091.
doi:10.3390/nu14153091 .

Zeković, Milica, Milešević, Jelena, Takić, Marija, Knez, Marija, Šarac, Ivana, Kadvan, Agnes, Gurinović, Mirjana, Glibetić, Marija, "Evaluation of Dietary Intake and Anthropometric Status in 1–9-Year-Old Children Living in Serbia: National Food Consumption Survey according to the EU Menu Methodology" in Nutrients, 14, no. 15 (2022):3091,
https://doi.org/10.3390/nu14153091 . .

TY  - JOUR
AU  - Ivanović, Nevena Đ.
AU  - Radosavljević, Branimir
AU  - Zeković, Milica
AU  - Korčok, Davor Jovan
AU  - Ignjatović, Svetlana
AU  - Đorđević, Brižita
AU  - Milinković, Neda
PY  - 2022
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1211
AB  - This study aimed to investigate the short-term effects of three magnesium (Mg) dietary supplements containing mineral immediately available for absorption on Mg biochemical status indices (ionized and total Mg), as well as their effects on electrolytes levels in healthy female young adults (n = 61). After a 10-days intervention period supplementation with powder/granulate containing Mg oxide led to an increase in both ionized Mg concentration and % in total Mg in comparison with the baseline. Supplementation with Mg citrate was associated with the significant increase in % of ionized fraction and decrease in serum total Mg concentration. By contrast, among participants consuming Mg carbonate in the form of effervescent tablets ionized Mg concentration and % in total Mg decreased, without detectable changes in serum total Mg. In conclusion, after the short-term supplementation period, Mg oxide demonstrated superior bioavailability compared to the other examined Mg supplements without affecting other minerals’ levels.
PB  - Springer Nature
T2  - BioMetals
T1  - Effects of short-term magnesium supplementation on ionized, total magnesium and other relevant electrolytes levels
EP  - 283
IS  - 2
SP  - 267
VL  - 35
DO  - 10.1007/s10534-022-00363-y
ER  - 

@article{
author = "Ivanović, Nevena Đ. and Radosavljević, Branimir and Zeković, Milica and Korčok, Davor Jovan and Ignjatović, Svetlana and Đorđević, Brižita and Milinković, Neda",
year = "2022",
abstract = "This study aimed to investigate the short-term effects of three magnesium (Mg) dietary supplements containing mineral immediately available for absorption on Mg biochemical status indices (ionized and total Mg), as well as their effects on electrolytes levels in healthy female young adults (n = 61). After a 10-days intervention period supplementation with powder/granulate containing Mg oxide led to an increase in both ionized Mg concentration and % in total Mg in comparison with the baseline. Supplementation with Mg citrate was associated with the significant increase in % of ionized fraction and decrease in serum total Mg concentration. By contrast, among participants consuming Mg carbonate in the form of effervescent tablets ionized Mg concentration and % in total Mg decreased, without detectable changes in serum total Mg. In conclusion, after the short-term supplementation period, Mg oxide demonstrated superior bioavailability compared to the other examined Mg supplements without affecting other minerals’ levels.",
publisher = "Springer Nature",
journal = "BioMetals",
title = "Effects of short-term magnesium supplementation on ionized, total magnesium and other relevant electrolytes levels",
pages = "283-267",
number = "2",
volume = "35",
doi = "10.1007/s10534-022-00363-y"
}

Ivanović, N. Đ., Radosavljević, B., Zeković, M., Korčok, D. J., Ignjatović, S., Đorđević, B.,& Milinković, N.. (2022). Effects of short-term magnesium supplementation on ionized, total magnesium and other relevant electrolytes levels. in BioMetals
Springer Nature., 35(2), 267-283.
https://doi.org/10.1007/s10534-022-00363-y

Ivanović NĐ, Radosavljević B, Zeković M, Korčok DJ, Ignjatović S, Đorđević B, Milinković N. Effects of short-term magnesium supplementation on ionized, total magnesium and other relevant electrolytes levels. in BioMetals. 2022;35(2):267-283.
doi:10.1007/s10534-022-00363-y .

Ivanović, Nevena Đ., Radosavljević, Branimir, Zeković, Milica, Korčok, Davor Jovan, Ignjatović, Svetlana, Đorđević, Brižita, Milinković, Neda, "Effects of short-term magnesium supplementation on ionized, total magnesium and other relevant electrolytes levels" in BioMetals, 35, no. 2 (2022):267-283,
https://doi.org/10.1007/s10534-022-00363-y . .

TY  - JOUR
AU  - Milinković, Neda
AU  - Zeković, Milica
AU  - Dodevska, Margarita
AU  - Đorđević, Brižita
AU  - Radosavljević, Branimir
AU  - Ignjatović, Svetlana
AU  - Ivanović, Nevena
PY  - 2022
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1272
AB  - Abstract  Background: Literature data indicate the benefit of magnesium (Mg) supplementation. The aim of this study was to examine the effect of short-term Mg supplementation on iron status in healthy female participants. Methods: One hundred healthy female students of the University of Belgrade - Faculty of Pharmacy participated the study during eleven intervention days. Students ingested Mg preparations with the same dose of the active substance. The analysis included the measurement of serum iron, unsaturated iron binding capacity (UIBC), total iron binding capacity (TIBC), total Mg (tMg), ionized Mg (iMg), complete blood count, met-, carboxy- and oxy-haemoglobin (metHgb, COHgb, O2Hgb). Transferrin concentrations and percentage of transferrin saturation (SAT) were calculated manually. The association among the analyzed biochemical parameters was examined using polynomial regression. A principal component analysis (PCA) was used for the evaluation of interdependence between the analyzed parameters. Results: A statistically significant trend for change in O2Hgb (%) by tertiles of iMg concentrations was found (P = 0.029). Serum tMg reached significant positive correlation with the SAT at concentration levels greater than 0.9 mmol/L, after 11 days of intervention (R2=0.116). Ionized Mg in a concentration higher than 0.6 mmol/L is positively correlated with SAT and serum Fe (R2=0.214; 0.199, respectively). PCA revealed variability of 64.7% for two axes after 11 days. Conclusions: Mg supplementation leads to an improvement in the certain iron status parameters even in individuals with optimal levels of these indices. However, caution should be exercised when supplementing Mg, and laboratory monitoring of the interaction is required.
AB  - Uvod: Literaturni podaci ukazuju na benefit suplementacije magnezijumom (Mg). Cilj ove studije bio je da se ispita uticaj kratkotrajne suplementacije Mg na status gvožđa kod zdravih žena. Metode: Sto zdravih studentkinja Univerzitet u Beogradu - Farmaceutskog fakulteta je učestvovalo u istraživanju tokom jedanaest dana intervencije. Studenti su uzimali preparate Mg sa istom dozom aktivne supstance. U serumu je određivano gvožđe, nezasićen kapacitet vezivanja gvožđa (UIBC), ukupan kapacitet vezivanja gvožđa (TIBC), ukupan Mg (tMg), jonizovni Mg (iMg), kompletna krvna slika, met-, karboksiioksihemoglobin (metHgb, COHgb, O2Hgb). Transferin i saturacija transferina (SAT) su izračunati ručno. Povezanost analiziranih biohemijskih parametara je ispitana pomoću polinomalne regresije. Za procenu međuzavisnosti između analiziranih parametara korišćena je analiza glavnih komponenti (PCA). Rezultati: Utvrđen je statistički značajan trend promene O2Hgb (%) po tertilima koncentracija iMg (P = 0,029). Ukupan Mg je dostigao značajnu pozitivnu korelaciju sa SAT pri koncentracijama većim od 0,9 mmol/L, nakon 11 dana intervencije (R2 = 0,116). Jonizovani Mg u koncentraciji većoj od 0,6 mmol/L pozitivno korelira sa SAT i gvožđem (R2 = 0,214; 0,199, redom). PCA analizom je pokazana varijabilnost od 64,7% za dve ose nakon 11 dana. Zaključak: Suplementacija Mg dovodi do poboljšanja određenih parametara statusa gvožđa čak i kod pojedinaca sa optimalnim nivoima ovih parametara. Međutim treba biti oprezan pri suplementaciji Mg, a dodatno je neophodno i laboratorijsko praćenje ovih interakcija.
T2  - Journal of Medical Biochemistry
T1  - Magnesium supplementation and iron status among female students: The intervention study
T1  - Suplementacija magnezijuma i status gvožđa kod studentkinja - studija intervencije
EP  - 326
IS  - 3
SP  - 316
VL  - 41
UR  - https://hdl.handle.net/21.15107/rcub_rimi_1272
ER  - 

@article{
author = "Milinković, Neda and Zeković, Milica and Dodevska, Margarita and Đorđević, Brižita and Radosavljević, Branimir and Ignjatović, Svetlana and Ivanović, Nevena",
year = "2022",
abstract = "Abstract  Background: Literature data indicate the benefit of magnesium (Mg) supplementation. The aim of this study was to examine the effect of short-term Mg supplementation on iron status in healthy female participants. Methods: One hundred healthy female students of the University of Belgrade - Faculty of Pharmacy participated the study during eleven intervention days. Students ingested Mg preparations with the same dose of the active substance. The analysis included the measurement of serum iron, unsaturated iron binding capacity (UIBC), total iron binding capacity (TIBC), total Mg (tMg), ionized Mg (iMg), complete blood count, met-, carboxy- and oxy-haemoglobin (metHgb, COHgb, O2Hgb). Transferrin concentrations and percentage of transferrin saturation (SAT) were calculated manually. The association among the analyzed biochemical parameters was examined using polynomial regression. A principal component analysis (PCA) was used for the evaluation of interdependence between the analyzed parameters. Results: A statistically significant trend for change in O2Hgb (%) by tertiles of iMg concentrations was found (P = 0.029). Serum tMg reached significant positive correlation with the SAT at concentration levels greater than 0.9 mmol/L, after 11 days of intervention (R2=0.116). Ionized Mg in a concentration higher than 0.6 mmol/L is positively correlated with SAT and serum Fe (R2=0.214; 0.199, respectively). PCA revealed variability of 64.7% for two axes after 11 days. Conclusions: Mg supplementation leads to an improvement in the certain iron status parameters even in individuals with optimal levels of these indices. However, caution should be exercised when supplementing Mg, and laboratory monitoring of the interaction is required., Uvod: Literaturni podaci ukazuju na benefit suplementacije magnezijumom (Mg). Cilj ove studije bio je da se ispita uticaj kratkotrajne suplementacije Mg na status gvožđa kod zdravih žena. Metode: Sto zdravih studentkinja Univerzitet u Beogradu - Farmaceutskog fakulteta je učestvovalo u istraživanju tokom jedanaest dana intervencije. Studenti su uzimali preparate Mg sa istom dozom aktivne supstance. U serumu je određivano gvožđe, nezasićen kapacitet vezivanja gvožđa (UIBC), ukupan kapacitet vezivanja gvožđa (TIBC), ukupan Mg (tMg), jonizovni Mg (iMg), kompletna krvna slika, met-, karboksiioksihemoglobin (metHgb, COHgb, O2Hgb). Transferin i saturacija transferina (SAT) su izračunati ručno. Povezanost analiziranih biohemijskih parametara je ispitana pomoću polinomalne regresije. Za procenu međuzavisnosti između analiziranih parametara korišćena je analiza glavnih komponenti (PCA). Rezultati: Utvrđen je statistički značajan trend promene O2Hgb (%) po tertilima koncentracija iMg (P = 0,029). Ukupan Mg je dostigao značajnu pozitivnu korelaciju sa SAT pri koncentracijama većim od 0,9 mmol/L, nakon 11 dana intervencije (R2 = 0,116). Jonizovani Mg u koncentraciji većoj od 0,6 mmol/L pozitivno korelira sa SAT i gvožđem (R2 = 0,214; 0,199, redom). PCA analizom je pokazana varijabilnost od 64,7% za dve ose nakon 11 dana. Zaključak: Suplementacija Mg dovodi do poboljšanja određenih parametara statusa gvožđa čak i kod pojedinaca sa optimalnim nivoima ovih parametara. Međutim treba biti oprezan pri suplementaciji Mg, a dodatno je neophodno i laboratorijsko praćenje ovih interakcija.",
journal = "Journal of Medical Biochemistry",
title = "Magnesium supplementation and iron status among female students: The intervention study, Suplementacija magnezijuma i status gvožđa kod studentkinja - studija intervencije",
pages = "326-316",
number = "3",
volume = "41",
url = "https://hdl.handle.net/21.15107/rcub_rimi_1272"
}

Milinković, N., Zeković, M., Dodevska, M., Đorđević, B., Radosavljević, B., Ignjatović, S.,& Ivanović, N.. (2022). Magnesium supplementation and iron status among female students: The intervention study. in Journal of Medical Biochemistry, 41(3), 316-326.
https://hdl.handle.net/21.15107/rcub_rimi_1272

Milinković N, Zeković M, Dodevska M, Đorđević B, Radosavljević B, Ignjatović S, Ivanović N. Magnesium supplementation and iron status among female students: The intervention study. in Journal of Medical Biochemistry. 2022;41(3):316-326.
https://hdl.handle.net/21.15107/rcub_rimi_1272 .

Milinković, Neda, Zeković, Milica, Dodevska, Margarita, Đorđević, Brižita, Radosavljević, Branimir, Ignjatović, Svetlana, Ivanović, Nevena, "Magnesium supplementation and iron status among female students: The intervention study" in Journal of Medical Biochemistry, 41, no. 3 (2022):316-326,
https://hdl.handle.net/21.15107/rcub_rimi_1272 .

TY  - JOUR
AU  - Šarac, Ivana
AU  - Jovanović, Jovica
AU  - Zec, Manja
AU  - Pavlović, Zoran
AU  - Debeljak-Martačić, Jasmina
AU  - Zeković, Milica
AU  - Milešević, Jelena
AU  - Gurinović, Mirjana
AU  - Glibetić, Marija
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1162
AB  - The status of vitamin D in underground working coal miners and its association with their cardiometabolic health is rarely studied. This study aimed to examine vitamin D (VitD) status in Serbian underground coal miners and to correlate it with anthropometric and laboratory indicators of cardiometabolic risk. Nutritional data (food frequency questionnaire, FFQ, and two times repeated 24 h recall), anthropometric data (including segmental analysis by bio-impedance analyzer TANITA BC-545N), arterial tension, and biochemical and hematological data of 103 coal miners (aged 22–63 years) were correlated with their late summer (early September) serum 25 (OH)D levels (measured by HPLC). 68.9% of the studied coal miners were overweight/obese, and 48.5% had metabolic syndrome. Their mean VitD nutritional intakes were low: 5.3 ± 3.8 μg/day (FFQ) and 4.9 ± 8 μg/day (24 h recalls), but their mean serum 25 (OH)D levels were surprisingly high (143.7 ± 41.4 nmol/L). Only 2.9% of the coal miners had 25(OH)D levels lower than 75 nmol/L (indicating an insufficient/deficient status), while 63.2% had values above 125 nmol/L (upper optimal limit), and even 10.7% had values above 200 nmol/L. There were no statistical differences in 25 (OH)D levels in the coal miners with or without metabolic syndrome (or overweight/obesity). Interestingly, 25(OH)D levels had significant positive correlations with body mass index (BMI), fat mass (FM), fat mass percentage (FM%), limbs FM%, serum triglycerides, GGT, AST, ALT, and ALT/AST ratio, and had significant negative correlations with serum HDL-cholesterol and age. All these correlations were lost after corrections for age, FM, FM%, and legs FM%. In Serbian coal miners, high levels of early September VitD levels were observed, indicating sufficient non-working-hour sun exposure during the summer period. Furthermore, the unexpected positive correlations of VitD levels with anthropometric and biochemical parameters indicative of obesity, metabolic syndrome, and fatty liver disease were found. More research is needed on the VitD status of coal miners (particularly in the winter period) and its relationship with their cardiometabolic status.
PB  - Frontiers Media
T2  - Frontiers in Nutrition
T1  - Vitamin D Status and Its Correlation With Anthropometric and Biochemical Indicators of Cardiometabolic Risk in Serbian Underground Coal Miners in 2016
SP  - 689214
VL  - 8
DO  - 10.3389/fnut.2021.689214
ER  - 

@article{
author = "Šarac, Ivana and Jovanović, Jovica and Zec, Manja and Pavlović, Zoran and Debeljak-Martačić, Jasmina and Zeković, Milica and Milešević, Jelena and Gurinović, Mirjana and Glibetić, Marija",
year = "2021",
abstract = "The status of vitamin D in underground working coal miners and its association with their cardiometabolic health is rarely studied. This study aimed to examine vitamin D (VitD) status in Serbian underground coal miners and to correlate it with anthropometric and laboratory indicators of cardiometabolic risk. Nutritional data (food frequency questionnaire, FFQ, and two times repeated 24 h recall), anthropometric data (including segmental analysis by bio-impedance analyzer TANITA BC-545N), arterial tension, and biochemical and hematological data of 103 coal miners (aged 22–63 years) were correlated with their late summer (early September) serum 25 (OH)D levels (measured by HPLC). 68.9% of the studied coal miners were overweight/obese, and 48.5% had metabolic syndrome. Their mean VitD nutritional intakes were low: 5.3 ± 3.8 μg/day (FFQ) and 4.9 ± 8 μg/day (24 h recalls), but their mean serum 25 (OH)D levels were surprisingly high (143.7 ± 41.4 nmol/L). Only 2.9% of the coal miners had 25(OH)D levels lower than 75 nmol/L (indicating an insufficient/deficient status), while 63.2% had values above 125 nmol/L (upper optimal limit), and even 10.7% had values above 200 nmol/L. There were no statistical differences in 25 (OH)D levels in the coal miners with or without metabolic syndrome (or overweight/obesity). Interestingly, 25(OH)D levels had significant positive correlations with body mass index (BMI), fat mass (FM), fat mass percentage (FM%), limbs FM%, serum triglycerides, GGT, AST, ALT, and ALT/AST ratio, and had significant negative correlations with serum HDL-cholesterol and age. All these correlations were lost after corrections for age, FM, FM%, and legs FM%. In Serbian coal miners, high levels of early September VitD levels were observed, indicating sufficient non-working-hour sun exposure during the summer period. Furthermore, the unexpected positive correlations of VitD levels with anthropometric and biochemical parameters indicative of obesity, metabolic syndrome, and fatty liver disease were found. More research is needed on the VitD status of coal miners (particularly in the winter period) and its relationship with their cardiometabolic status.",
publisher = "Frontiers Media",
journal = "Frontiers in Nutrition",
title = "Vitamin D Status and Its Correlation With Anthropometric and Biochemical Indicators of Cardiometabolic Risk in Serbian Underground Coal Miners in 2016",
pages = "689214",
volume = "8",
doi = "10.3389/fnut.2021.689214"
}

Šarac, I., Jovanović, J., Zec, M., Pavlović, Z., Debeljak-Martačić, J., Zeković, M., Milešević, J., Gurinović, M.,& Glibetić, M.. (2021). Vitamin D Status and Its Correlation With Anthropometric and Biochemical Indicators of Cardiometabolic Risk in Serbian Underground Coal Miners in 2016. in Frontiers in Nutrition
Frontiers Media., 8, 689214.
https://doi.org/10.3389/fnut.2021.689214

Šarac I, Jovanović J, Zec M, Pavlović Z, Debeljak-Martačić J, Zeković M, Milešević J, Gurinović M, Glibetić M. Vitamin D Status and Its Correlation With Anthropometric and Biochemical Indicators of Cardiometabolic Risk in Serbian Underground Coal Miners in 2016. in Frontiers in Nutrition. 2021;8:689214.
doi:10.3389/fnut.2021.689214 .

Šarac, Ivana, Jovanović, Jovica, Zec, Manja, Pavlović, Zoran, Debeljak-Martačić, Jasmina, Zeković, Milica, Milešević, Jelena, Gurinović, Mirjana, Glibetić, Marija, "Vitamin D Status and Its Correlation With Anthropometric and Biochemical Indicators of Cardiometabolic Risk in Serbian Underground Coal Miners in 2016" in Frontiers in Nutrition, 8 (2021):689214,
https://doi.org/10.3389/fnut.2021.689214 . .

TY  - JOUR
AU  - Milićević, Dragan R.
AU  - Milešević, Jelena
AU  - Gurinović, Mirjana
AU  - Janković, Saša
AU  - Đinović-Stojanović, Jasna
AU  - Zeković, Milica
AU  - Glibetić, Marija
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1182
AB  - The present study was conducted to estimate the exposure and characterize the risk for the child population of Serbia to Aflatoxin M1 (AFM1) from milk and milk-based food. A total of 3404 samples comprising milk and different milk-based food samples were collected from various regions of Serbia from 2017 to 2019. Evaluation of AFM1 exposure was carried out using the deterministic method, whereas risk characterization was evaluated using the margin of exposure (MOE) and the risk of hepatocellular carcinoma (HCC). Detection rates for AFM1 in milk and milk-based food samples ranged between 2% and 79%, with the highest incidence (79%) and mean level (22.34 ± 0.018 ng kg−1) of AFM1 being detected in pasteurized and UHT milk. According to the three consumption estimates, the values of estimated daily intake (EDI) were higher for toddlers as compared with children aged 3–9 years. Children aged 1–3 years had the highest risk of exposure to AFM1 in milk, with an estimated daily intake of 0.164 and 0.193 ng kg−1 bw day−1 using lower bound (LB) and upper bound (UB) exposure scenarios, respectively. Such difference could result from the higher consumption to weight in younger children. Based on the estimated daily intake (EDI) found in this study, the risk of AFM1 exposure due to consumption of milk and milk-based food was low since the MOE values obtained were >10,000. In addition, the risk of HCC cases/year/105 individuals of different age groups showed that the value of HCC, using potency estimates of 0.0017 (mean), was maximum (0.00034) in the age group 1–3 years, which indicates no health risk for the evaluated groups. The present study revealed the importance of controlling and preventing AFM1 contamination in milk through continuous monitoring and regular inspection to reduce the risk of AFM1 exposure, especially in children.
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Nutrients
T1  - Dietary Exposure and Risk Assessment of Aflatoxin M1 for Children Aged 1 to 9 Years Old in Serbia
IS  - 12
SP  - 4450
VL  - 13
DO  - 10.3390/nu13124450
ER  - 

@article{
author = "Milićević, Dragan R. and Milešević, Jelena and Gurinović, Mirjana and Janković, Saša and Đinović-Stojanović, Jasna and Zeković, Milica and Glibetić, Marija",
year = "2021",
abstract = "The present study was conducted to estimate the exposure and characterize the risk for the child population of Serbia to Aflatoxin M1 (AFM1) from milk and milk-based food. A total of 3404 samples comprising milk and different milk-based food samples were collected from various regions of Serbia from 2017 to 2019. Evaluation of AFM1 exposure was carried out using the deterministic method, whereas risk characterization was evaluated using the margin of exposure (MOE) and the risk of hepatocellular carcinoma (HCC). Detection rates for AFM1 in milk and milk-based food samples ranged between 2% and 79%, with the highest incidence (79%) and mean level (22.34 ± 0.018 ng kg−1) of AFM1 being detected in pasteurized and UHT milk. According to the three consumption estimates, the values of estimated daily intake (EDI) were higher for toddlers as compared with children aged 3–9 years. Children aged 1–3 years had the highest risk of exposure to AFM1 in milk, with an estimated daily intake of 0.164 and 0.193 ng kg−1 bw day−1 using lower bound (LB) and upper bound (UB) exposure scenarios, respectively. Such difference could result from the higher consumption to weight in younger children. Based on the estimated daily intake (EDI) found in this study, the risk of AFM1 exposure due to consumption of milk and milk-based food was low since the MOE values obtained were >10,000. In addition, the risk of HCC cases/year/105 individuals of different age groups showed that the value of HCC, using potency estimates of 0.0017 (mean), was maximum (0.00034) in the age group 1–3 years, which indicates no health risk for the evaluated groups. The present study revealed the importance of controlling and preventing AFM1 contamination in milk through continuous monitoring and regular inspection to reduce the risk of AFM1 exposure, especially in children.",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Nutrients",
title = "Dietary Exposure and Risk Assessment of Aflatoxin M1 for Children Aged 1 to 9 Years Old in Serbia",
number = "12",
pages = "4450",
volume = "13",
doi = "10.3390/nu13124450"
}

Milićević, D. R., Milešević, J., Gurinović, M., Janković, S., Đinović-Stojanović, J., Zeković, M.,& Glibetić, M.. (2021). Dietary Exposure and Risk Assessment of Aflatoxin M1 for Children Aged 1 to 9 Years Old in Serbia. in Nutrients
Multidisciplinary Digital Publishing Institute (MDPI)., 13(12), 4450.
https://doi.org/10.3390/nu13124450

Milićević DR, Milešević J, Gurinović M, Janković S, Đinović-Stojanović J, Zeković M, Glibetić M. Dietary Exposure and Risk Assessment of Aflatoxin M1 for Children Aged 1 to 9 Years Old in Serbia. in Nutrients. 2021;13(12):4450.
doi:10.3390/nu13124450 .

Milićević, Dragan R., Milešević, Jelena, Gurinović, Mirjana, Janković, Saša, Đinović-Stojanović, Jasna, Zeković, Milica, Glibetić, Marija, "Dietary Exposure and Risk Assessment of Aflatoxin M1 for Children Aged 1 to 9 Years Old in Serbia" in Nutrients, 13, no. 12 (2021):4450,
https://doi.org/10.3390/nu13124450 . .

TY  - JOUR
AU  - Takić, Marija
AU  - Zeković, Milica
AU  - Terzić, Brankica
AU  - Stojsavljević, Aleksandar
AU  - Mijušković, Mirjana
AU  - Rađen, Slavica
AU  - Ristić-Medić, Danijela
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1200
AB  - Background: Desaturation and elongation are critical processes in endogenous metabolic fatty acid pathways. Zinc (Zn) is a cofactor for desaturases and elongases enzymes. There is limited evidence regarding the relationships between biomarkers of Zn status, nutritional intake, plasma phospholipid fatty acid profile and clinical outcomes among patients undergoing hemodialysis (HD).  Objective: To examine the relationships between dietary and serum levels of Zn and Cu/Zn ratio and to explore associations of these micronutrients with PUFA profile and estimated desaturase and elongase enzyme activities in serum phospholipids among HD patients.  Methods: This study included 40 adult patients undergoing hemodialysis treatment. Repeated 24-h recalls were applied for dietary intake assessment. Serum concentration of Zn and Cu were determined using inductively coupled plasma mass spectrometry and fatty acid composition by gas-liquid chromatography. Desaturase and elongase activities were calculated from product-precursor fatty acid ratios.  Results: Inadequate dietary Zn intake was found in 55% of HD patients. They all had serum Zn concentration below the reference value of 60 μg/dL (mean 38.8 ± 7.72 μg/dL). Adequate zinc intake was accompanied with significantly higher intake of energy, total fats, SFA, MUFA and proteins. There was no correlation between Zn serum status and Zn intake estimates. Serum Cu/Zn ratio was high, (2.76 ± 0.68), directly and significantly associated with HD period, CRP, BMI, VFA, and inversely with Kt/V, albumin, iron, and iPTH. The n-6/n-3 ratio in plasma phospholipids was elevated (12.25 ± 3.45) and patients with inadequate Zn intake had lower n-3 PUFA intake and status compared to those with adequate intake. Serum Zn concentrations were inversely correlated with linoleic/dihomo-γ-linolenic acid ratio (LA/DGLA) (p = 0.037), related to D6-desaturase activity (p = 0.033) and directly with DGLA relative abundances (p = 0.024). Cu status was inversely associated with EPA level (p = 0.03) and estimates of elongase activity (p = 0.001). Furthermore, positive relationship was found between the Cu/Zn ratio and determined elongase value (p = 0.01).  Conclusion: Findings of this study underpin the high prevalence of Zn deficiency and inadequate n-3 PUFA intake and status among subjects undergoing HD. The results obtained indicate that the assessment of Zn status should be a standard parameter of nutritional status screening in HD patients while emphasizing the importance of Cu/Zn determination. Although further research is warranted, Zn and-n-3 PUFA supplementation in HD patients might be beneficial for the prevention and attenuation of adverse health outcomes.
PB  - Frontiers Media S.A.
T2  - Frontiers in Nutrition
T1  - Zinc Deficiency, Plasma Fatty Acid Profile and Desaturase Activities in Hemodialysis Patients: Is Supplementation Necessary?
SP  - 700450
VL  - 8
UR  - https://hdl.handle.net/21.15107/rcub_rimi_1200
ER  - 

@article{
author = "Takić, Marija and Zeković, Milica and Terzić, Brankica and Stojsavljević, Aleksandar and Mijušković, Mirjana and Rađen, Slavica and Ristić-Medić, Danijela",
year = "2021",
abstract = "Background: Desaturation and elongation are critical processes in endogenous metabolic fatty acid pathways. Zinc (Zn) is a cofactor for desaturases and elongases enzymes. There is limited evidence regarding the relationships between biomarkers of Zn status, nutritional intake, plasma phospholipid fatty acid profile and clinical outcomes among patients undergoing hemodialysis (HD).  Objective: To examine the relationships between dietary and serum levels of Zn and Cu/Zn ratio and to explore associations of these micronutrients with PUFA profile and estimated desaturase and elongase enzyme activities in serum phospholipids among HD patients.  Methods: This study included 40 adult patients undergoing hemodialysis treatment. Repeated 24-h recalls were applied for dietary intake assessment. Serum concentration of Zn and Cu were determined using inductively coupled plasma mass spectrometry and fatty acid composition by gas-liquid chromatography. Desaturase and elongase activities were calculated from product-precursor fatty acid ratios.  Results: Inadequate dietary Zn intake was found in 55% of HD patients. They all had serum Zn concentration below the reference value of 60 μg/dL (mean 38.8 ± 7.72 μg/dL). Adequate zinc intake was accompanied with significantly higher intake of energy, total fats, SFA, MUFA and proteins. There was no correlation between Zn serum status and Zn intake estimates. Serum Cu/Zn ratio was high, (2.76 ± 0.68), directly and significantly associated with HD period, CRP, BMI, VFA, and inversely with Kt/V, albumin, iron, and iPTH. The n-6/n-3 ratio in plasma phospholipids was elevated (12.25 ± 3.45) and patients with inadequate Zn intake had lower n-3 PUFA intake and status compared to those with adequate intake. Serum Zn concentrations were inversely correlated with linoleic/dihomo-γ-linolenic acid ratio (LA/DGLA) (p = 0.037), related to D6-desaturase activity (p = 0.033) and directly with DGLA relative abundances (p = 0.024). Cu status was inversely associated with EPA level (p = 0.03) and estimates of elongase activity (p = 0.001). Furthermore, positive relationship was found between the Cu/Zn ratio and determined elongase value (p = 0.01).  Conclusion: Findings of this study underpin the high prevalence of Zn deficiency and inadequate n-3 PUFA intake and status among subjects undergoing HD. The results obtained indicate that the assessment of Zn status should be a standard parameter of nutritional status screening in HD patients while emphasizing the importance of Cu/Zn determination. Although further research is warranted, Zn and-n-3 PUFA supplementation in HD patients might be beneficial for the prevention and attenuation of adverse health outcomes.",
publisher = "Frontiers Media S.A.",
journal = "Frontiers in Nutrition",
title = "Zinc Deficiency, Plasma Fatty Acid Profile and Desaturase Activities in Hemodialysis Patients: Is Supplementation Necessary?",
pages = "700450",
volume = "8",
url = "https://hdl.handle.net/21.15107/rcub_rimi_1200"
}

Takić, M., Zeković, M., Terzić, B., Stojsavljević, A., Mijušković, M., Rađen, S.,& Ristić-Medić, D.. (2021). Zinc Deficiency, Plasma Fatty Acid Profile and Desaturase Activities in Hemodialysis Patients: Is Supplementation Necessary?. in Frontiers in Nutrition
Frontiers Media S.A.., 8, 700450.
https://hdl.handle.net/21.15107/rcub_rimi_1200

Takić M, Zeković M, Terzić B, Stojsavljević A, Mijušković M, Rađen S, Ristić-Medić D. Zinc Deficiency, Plasma Fatty Acid Profile and Desaturase Activities in Hemodialysis Patients: Is Supplementation Necessary?. in Frontiers in Nutrition. 2021;8:700450.
https://hdl.handle.net/21.15107/rcub_rimi_1200 .

Takić, Marija, Zeković, Milica, Terzić, Brankica, Stojsavljević, Aleksandar, Mijušković, Mirjana, Rađen, Slavica, Ristić-Medić, Danijela, "Zinc Deficiency, Plasma Fatty Acid Profile and Desaturase Activities in Hemodialysis Patients: Is Supplementation Necessary?" in Frontiers in Nutrition, 8 (2021):700450,
https://hdl.handle.net/21.15107/rcub_rimi_1200 .

TY  - JOUR
AU  - Gurinović, Mirjana
AU  - Milešević, Jelena
AU  - Zeković, Milica
AU  - Kadvan, Agnes
AU  - Ranić, Marija M.
AU  - Glibetić, Marija
PY  - 2020
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/986
AB  - This article summarizes the activities performed by the Network for Capacity Development in Nutrition in Central and Eastern Europe and Balkan countries (NCDNCEE) in the past decade. The article gives a retrospective of the achievements and challenges in building capacity in nutrition research. Recognizing the lack of capacity and incoherent nutritional situation in CEE/BC, the United Nations University (UNU), Food & Nutrition Programme and the UN Standing Committee on Nutrition (SCN) encouraged the formation of NCDNCEE in 2005, which became CAPNUTRA in 2012. The network's aim was to initiate and support tailor-made activities for capacity development in food & nutrition in research and training in CEE/BC. To identify the challenges and needs of nutrition research in the region, the network performed inventories on existence of food composition databases, food systems elements, dietary surveys, micronutrient recommendations, application of dietary assessment methods and grey literature. Further on, the network focused on the development of food composition databases and concomitant data management software, the Diet Assess & Plan platform for food consumption collection, dietary intake assessment and nutrition planning. These and other elements form the Balkan Food Platform, which underpins harmonized nutrition research in CEE/BC. Among key actions promoted by the platform are EFSA-supported dietary surveys conducted in four Balkan countries, on children and adults, in which food consumption data are collected and analysed in a harmonized way. Cooperation with FAO and active participation in international research projects enhanced the exchange of information and knowledge and brought international recognition to the CAPNUTRA network.
PB  - Elsevier Sci Ltd, Oxford
T2  - Food Policy
T1  - Capacity development in food and nutrition in central and Eastern Europe: A decade of achievements
SP  - 101850
VL  - 96
DO  - 10.1016/j.foodpol.2020.101850
ER  - 

@article{
author = "Gurinović, Mirjana and Milešević, Jelena and Zeković, Milica and Kadvan, Agnes and Ranić, Marija M. and Glibetić, Marija",
year = "2020",
abstract = "This article summarizes the activities performed by the Network for Capacity Development in Nutrition in Central and Eastern Europe and Balkan countries (NCDNCEE) in the past decade. The article gives a retrospective of the achievements and challenges in building capacity in nutrition research. Recognizing the lack of capacity and incoherent nutritional situation in CEE/BC, the United Nations University (UNU), Food & Nutrition Programme and the UN Standing Committee on Nutrition (SCN) encouraged the formation of NCDNCEE in 2005, which became CAPNUTRA in 2012. The network's aim was to initiate and support tailor-made activities for capacity development in food & nutrition in research and training in CEE/BC. To identify the challenges and needs of nutrition research in the region, the network performed inventories on existence of food composition databases, food systems elements, dietary surveys, micronutrient recommendations, application of dietary assessment methods and grey literature. Further on, the network focused on the development of food composition databases and concomitant data management software, the Diet Assess & Plan platform for food consumption collection, dietary intake assessment and nutrition planning. These and other elements form the Balkan Food Platform, which underpins harmonized nutrition research in CEE/BC. Among key actions promoted by the platform are EFSA-supported dietary surveys conducted in four Balkan countries, on children and adults, in which food consumption data are collected and analysed in a harmonized way. Cooperation with FAO and active participation in international research projects enhanced the exchange of information and knowledge and brought international recognition to the CAPNUTRA network.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Food Policy",
title = "Capacity development in food and nutrition in central and Eastern Europe: A decade of achievements",
pages = "101850",
volume = "96",
doi = "10.1016/j.foodpol.2020.101850"
}

Gurinović, M., Milešević, J., Zeković, M., Kadvan, A., Ranić, M. M.,& Glibetić, M.. (2020). Capacity development in food and nutrition in central and Eastern Europe: A decade of achievements. in Food Policy
Elsevier Sci Ltd, Oxford., 96, 101850.
https://doi.org/10.1016/j.foodpol.2020.101850

Gurinović M, Milešević J, Zeković M, Kadvan A, Ranić MM, Glibetić M. Capacity development in food and nutrition in central and Eastern Europe: A decade of achievements. in Food Policy. 2020;96:101850.
doi:10.1016/j.foodpol.2020.101850 .

Gurinović, Mirjana, Milešević, Jelena, Zeković, Milica, Kadvan, Agnes, Ranić, Marija M., Glibetić, Marija, "Capacity development in food and nutrition in central and Eastern Europe: A decade of achievements" in Food Policy, 96 (2020):101850,
https://doi.org/10.1016/j.foodpol.2020.101850 . .

TY  - JOUR
AU  - Stevanović, Vuk
AU  - Pantović, Ana
AU  - Krga, Irena
AU  - Zeković, Milica
AU  - Šarac, Ivana
AU  - Glibetić, Marija
AU  - Vidović, Nevena Đ.
PY  - 2020
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1021
AB  - Long-distance running, especially in non-professional runners, can increase cardiac arrest risk by enhancing platelet activation and aggregation. Polyphenols can exert cardioprotective effects by positively influencing platelet function. This study aimed to examine the acute effects of polyphenol-rich aronia juice consumption, before simulation of a half-marathon race, on platelet activation and aggregation with leukocytes in recreational runners. In this acute crossover study,10 healthy male runners (age 30.8 +/- 2.3 years) consumed breakfast with 200 mL, of aronia juice or 200 mL of placebo. They warmed-up and ran a simulated half-marathon race (21.1 km). Blood was collected at baseline, and at 15 min, 1 h, and 24 h after the run. All variables were analyzed with 4 (time) x 2 (group)ANOVA with repeated measures on both factors. Results revealed a significant effect of group on platelet activation parameters: P-selectin and CPIIb-IIIa expressions significantly decreased in the aronia group compared with the placebo group (F-[1.(9]) = 10.282, p = 0.011 and F-[1.9] = 7.860, p = 0.021, respectively). The effect of rime was significant on both platelet aggregation markers: platelet-monocyte and platelet-neutrophil aggregates were significantly lower after the race (F-[(3).7] = 4.227, p = 0.014 and F-[3.7] = 70.065, p = 0.000, respectively), with changes more pronounced in the later. All effects remained when platelets were exposed to an agonist. These results suggest that aronia consumption could counteract the half-marathon race-induced changes in platelet function. Novelty Aronia juice consumption significantly decreased the expression of platelet activation markers but did not affect platelet aggregation. The race itself did significantly reduce platelet-neutrophil aggregation. Aronia juice may serve as a supplement beverage for recreational runners to alleviate enhanced platelet reactivity caused by prolonged running.
PB  - Canadian Science Publishing, Ottawa
T2  - Applied Physiology Nutrition & Metabolism
T1  - Aronia juice consumption prior to half-marathon race can acutely affect platelet activation in recreational runners
EP  - 400
IS  - 4
SP  - 393
VL  - 45
DO  - 10.1139/apnm-2019-0267
ER  - 

@article{
author = "Stevanović, Vuk and Pantović, Ana and Krga, Irena and Zeković, Milica and Šarac, Ivana and Glibetić, Marija and Vidović, Nevena Đ.",
year = "2020",
abstract = "Long-distance running, especially in non-professional runners, can increase cardiac arrest risk by enhancing platelet activation and aggregation. Polyphenols can exert cardioprotective effects by positively influencing platelet function. This study aimed to examine the acute effects of polyphenol-rich aronia juice consumption, before simulation of a half-marathon race, on platelet activation and aggregation with leukocytes in recreational runners. In this acute crossover study,10 healthy male runners (age 30.8 +/- 2.3 years) consumed breakfast with 200 mL, of aronia juice or 200 mL of placebo. They warmed-up and ran a simulated half-marathon race (21.1 km). Blood was collected at baseline, and at 15 min, 1 h, and 24 h after the run. All variables were analyzed with 4 (time) x 2 (group)ANOVA with repeated measures on both factors. Results revealed a significant effect of group on platelet activation parameters: P-selectin and CPIIb-IIIa expressions significantly decreased in the aronia group compared with the placebo group (F-[1.(9]) = 10.282, p = 0.011 and F-[1.9] = 7.860, p = 0.021, respectively). The effect of rime was significant on both platelet aggregation markers: platelet-monocyte and platelet-neutrophil aggregates were significantly lower after the race (F-[(3).7] = 4.227, p = 0.014 and F-[3.7] = 70.065, p = 0.000, respectively), with changes more pronounced in the later. All effects remained when platelets were exposed to an agonist. These results suggest that aronia consumption could counteract the half-marathon race-induced changes in platelet function. Novelty Aronia juice consumption significantly decreased the expression of platelet activation markers but did not affect platelet aggregation. The race itself did significantly reduce platelet-neutrophil aggregation. Aronia juice may serve as a supplement beverage for recreational runners to alleviate enhanced platelet reactivity caused by prolonged running.",
publisher = "Canadian Science Publishing, Ottawa",
journal = "Applied Physiology Nutrition & Metabolism",
title = "Aronia juice consumption prior to half-marathon race can acutely affect platelet activation in recreational runners",
pages = "400-393",
number = "4",
volume = "45",
doi = "10.1139/apnm-2019-0267"
}

Stevanović, V., Pantović, A., Krga, I., Zeković, M., Šarac, I., Glibetić, M.,& Vidović, N. Đ.. (2020). Aronia juice consumption prior to half-marathon race can acutely affect platelet activation in recreational runners. in Applied Physiology Nutrition & Metabolism
Canadian Science Publishing, Ottawa., 45(4), 393-400.
https://doi.org/10.1139/apnm-2019-0267

Stevanović V, Pantović A, Krga I, Zeković M, Šarac I, Glibetić M, Vidović NĐ. Aronia juice consumption prior to half-marathon race can acutely affect platelet activation in recreational runners. in Applied Physiology Nutrition & Metabolism. 2020;45(4):393-400.
doi:10.1139/apnm-2019-0267 .

Stevanović, Vuk, Pantović, Ana, Krga, Irena, Zeković, Milica, Šarac, Ivana, Glibetić, Marija, Vidović, Nevena Đ., "Aronia juice consumption prior to half-marathon race can acutely affect platelet activation in recreational runners" in Applied Physiology Nutrition & Metabolism, 45, no. 4 (2020):393-400,
https://doi.org/10.1139/apnm-2019-0267 . .

TY  - JOUR
AU  - Pantović, Ana
AU  - Krga, Irena
AU  - Zeković, Milica
AU  - Šarac, Ivana
AU  - Glibetić, Marija
AU  - Vidović, Nevena Đ.
PY  - 2020
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1127
AB  - Long-distance running, especially in non-professional runners, can increase cardiac arrest risk by enhancing platelet activation and aggregation. Polyphenols can exert cardioprotective effects by positively influencing platelet function. This study aimed to examine the acute effects of polyphenol-rich aronia juice consumption, before simulation of a half-marathon race, on platelet activation and aggregation with leukocytes in recreational runners. In this acute crossover study,10 healthy male runners (age 30.8 +/- 2.3 years) consumed breakfast with 200 mL, of aronia juice or 200 mL of placebo. They warmed-up and ran a simulated half-marathon race (21.1 km). Blood was collected at baseline, and at 15 min, 1 h, and 24 h after the run. All variables were analyzed with 4 (time) x 2 (group)ANOVA with repeated measures on both factors. Results revealed a significant effect of group on platelet activation parameters: P-selectin and CPIIb-IIIa expressions significantly decreased in the aronia group compared with the placebo group (F-[1.(9]) = 10.282, p = 0.011 and F-[1.9] = 7.860, p = 0.021, respectively). The effect of rime was significant on both platelet aggregation markers: platelet-monocyte and platelet-neutrophil aggregates were significantly lower after the race (F-[(3).7] = 4.227, p = 0.014 and F-[3.7] = 70.065, p = 0.000, respectively), with changes more pronounced in the later. All effects remained when platelets were exposed to an agonist. These results suggest that aronia consumption could counteract the half-marathon race-induced changes in platelet function. Novelty Aronia juice consumption significantly decreased the expression of platelet activation markers but did not affect platelet aggregation. The race itself did significantly reduce platelet-neutrophil aggregation. Aronia juice may serve as a supplement beverage for recreational runners to alleviate enhanced platelet reactivity caused by prolonged running.
PB  - Canadian Science Publishing, Ottawa
T2  - Applied Physiology Nutrition & Metabolism
T1  - Aronia juice consumption prior to half-marathon race can acutely affect platelet activation in recreational runners
EP  - 400
IS  - 4
SP  - 393
VL  - 45
DO  - 10.1139/apnm-2019-0267
ER  - 

@article{
author = "Pantović, Ana and Krga, Irena and Zeković, Milica and Šarac, Ivana and Glibetić, Marija and Vidović, Nevena Đ.",
year = "2020",
abstract = "Long-distance running, especially in non-professional runners, can increase cardiac arrest risk by enhancing platelet activation and aggregation. Polyphenols can exert cardioprotective effects by positively influencing platelet function. This study aimed to examine the acute effects of polyphenol-rich aronia juice consumption, before simulation of a half-marathon race, on platelet activation and aggregation with leukocytes in recreational runners. In this acute crossover study,10 healthy male runners (age 30.8 +/- 2.3 years) consumed breakfast with 200 mL, of aronia juice or 200 mL of placebo. They warmed-up and ran a simulated half-marathon race (21.1 km). Blood was collected at baseline, and at 15 min, 1 h, and 24 h after the run. All variables were analyzed with 4 (time) x 2 (group)ANOVA with repeated measures on both factors. Results revealed a significant effect of group on platelet activation parameters: P-selectin and CPIIb-IIIa expressions significantly decreased in the aronia group compared with the placebo group (F-[1.(9]) = 10.282, p = 0.011 and F-[1.9] = 7.860, p = 0.021, respectively). The effect of rime was significant on both platelet aggregation markers: platelet-monocyte and platelet-neutrophil aggregates were significantly lower after the race (F-[(3).7] = 4.227, p = 0.014 and F-[3.7] = 70.065, p = 0.000, respectively), with changes more pronounced in the later. All effects remained when platelets were exposed to an agonist. These results suggest that aronia consumption could counteract the half-marathon race-induced changes in platelet function. Novelty Aronia juice consumption significantly decreased the expression of platelet activation markers but did not affect platelet aggregation. The race itself did significantly reduce platelet-neutrophil aggregation. Aronia juice may serve as a supplement beverage for recreational runners to alleviate enhanced platelet reactivity caused by prolonged running.",
publisher = "Canadian Science Publishing, Ottawa",
journal = "Applied Physiology Nutrition & Metabolism",
title = "Aronia juice consumption prior to half-marathon race can acutely affect platelet activation in recreational runners",
pages = "400-393",
number = "4",
volume = "45",
doi = "10.1139/apnm-2019-0267"
}

Pantović, A., Krga, I., Zeković, M., Šarac, I., Glibetić, M.,& Vidović, N. Đ.. (2020). Aronia juice consumption prior to half-marathon race can acutely affect platelet activation in recreational runners. in Applied Physiology Nutrition & Metabolism
Canadian Science Publishing, Ottawa., 45(4), 393-400.
https://doi.org/10.1139/apnm-2019-0267

Pantović A, Krga I, Zeković M, Šarac I, Glibetić M, Vidović NĐ. Aronia juice consumption prior to half-marathon race can acutely affect platelet activation in recreational runners. in Applied Physiology Nutrition & Metabolism. 2020;45(4):393-400.
doi:10.1139/apnm-2019-0267 .

Pantović, Ana, Krga, Irena, Zeković, Milica, Šarac, Ivana, Glibetić, Marija, Vidović, Nevena Đ., "Aronia juice consumption prior to half-marathon race can acutely affect platelet activation in recreational runners" in Applied Physiology Nutrition & Metabolism, 45, no. 4 (2020):393-400,
https://doi.org/10.1139/apnm-2019-0267 . .