TY  - JOUR
AU  - Dakić, Tamara
AU  - Lakić, Iva
AU  - Zec, Manja
AU  - Takić, Marija
AU  - Stojiljković, Mojca
AU  - Jevđović, Tanja
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1197
AB  - BACKGROUND: Nutritional modulations may be considered a strategy to protect mental health. Neuronal homeostasis is highly dependent on the availability of glucose, which represents the primary energy source for the brain. In this study, we evaluated the effects of walnut intake and fructose-rich diet on the expression of glucose transporters (GLUTs) in two rat brain regions: hypothalamus and hippocampus. RESULTS: Our results show that walnut supplementation of fructose-fed animals restored the hypothalamic content of GLUT1 and GLUT3 protein. Furthermore, walnut intake did not affect increased hypothalamic GLUT2 content upon fructose consumption. These effects were accompanied by distinctive alterations of hippocampal GLUTs levels. Specifically, walnut intake increased GLUT1 content, whereas GLUT2 protein was decreased within the rat hippocampus after both individual and combined treatments. CONCLUSION: Overall, our study suggests that walnut supplementation exerted modulatory effects on the glucose transporters within specific brain regions in the presence of developed metabolic disorder.
PB  - Wiley
T2  - Journal of the Science of Food and Agriculture
T1  - Fructose-rich diet and walnut supplementation differently regulate rat hypothalamic and hippocampal glucose transporters expression
EP  - 5991
IS  - 14
SP  - 5984
VL  - 101
DO  - 10.1002/jsfa.11252
ER  - 

@article{
author = "Dakić, Tamara and Lakić, Iva and Zec, Manja and Takić, Marija and Stojiljković, Mojca and Jevđović, Tanja",
year = "2021",
abstract = "BACKGROUND: Nutritional modulations may be considered a strategy to protect mental health. Neuronal homeostasis is highly dependent on the availability of glucose, which represents the primary energy source for the brain. In this study, we evaluated the effects of walnut intake and fructose-rich diet on the expression of glucose transporters (GLUTs) in two rat brain regions: hypothalamus and hippocampus. RESULTS: Our results show that walnut supplementation of fructose-fed animals restored the hypothalamic content of GLUT1 and GLUT3 protein. Furthermore, walnut intake did not affect increased hypothalamic GLUT2 content upon fructose consumption. These effects were accompanied by distinctive alterations of hippocampal GLUTs levels. Specifically, walnut intake increased GLUT1 content, whereas GLUT2 protein was decreased within the rat hippocampus after both individual and combined treatments. CONCLUSION: Overall, our study suggests that walnut supplementation exerted modulatory effects on the glucose transporters within specific brain regions in the presence of developed metabolic disorder.",
publisher = "Wiley",
journal = "Journal of the Science of Food and Agriculture",
title = "Fructose-rich diet and walnut supplementation differently regulate rat hypothalamic and hippocampal glucose transporters expression",
pages = "5991-5984",
number = "14",
volume = "101",
doi = "10.1002/jsfa.11252"
}

Dakić, T., Lakić, I., Zec, M., Takić, M., Stojiljković, M.,& Jevđović, T.. (2021). Fructose-rich diet and walnut supplementation differently regulate rat hypothalamic and hippocampal glucose transporters expression. in Journal of the Science of Food and Agriculture
Wiley., 101(14), 5984-5991.
https://doi.org/10.1002/jsfa.11252

Dakić T, Lakić I, Zec M, Takić M, Stojiljković M, Jevđović T. Fructose-rich diet and walnut supplementation differently regulate rat hypothalamic and hippocampal glucose transporters expression. in Journal of the Science of Food and Agriculture. 2021;101(14):5984-5991.
doi:10.1002/jsfa.11252 .

Dakić, Tamara, Lakić, Iva, Zec, Manja, Takić, Marija, Stojiljković, Mojca, Jevđović, Tanja, "Fructose-rich diet and walnut supplementation differently regulate rat hypothalamic and hippocampal glucose transporters expression" in Journal of the Science of Food and Agriculture, 101, no. 14 (2021):5984-5991,
https://doi.org/10.1002/jsfa.11252 . .

TY  - JOUR
AU  - Stanisić, Jelena
AU  - Ivković, Tamara
AU  - Romić, Snježana
AU  - Zec, Manja M.
AU  - Culafić, Tijana
AU  - Stojiljković, Mojca
AU  - Korićanac, Goran
PY  - 2020
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/7
AB  - Consumption of walnuts is beneficial for cardiovascular health. To study walnut effects on proteins involved in vascular tone regulation, control and fructose-fed rats were subjected to walnut diet for 6 weeks. In contrast with increased energy intake and body mass gain, aortic protein level of L-type calcium channel alpha subunit was decreased and the level of SUR2B subunit of ATP-sensitive K + channel was increased in healthy rats subjected to walnuts, together with improved Akt phosphorylation. Upon the walnut diet in rats subjected to fructose overload, the rise in energy intake and body mass gain, was followed by an increase in blood insulin. Although SUR2B level was elevated, the level of sodium-calcium exchanger NCX1 and inducible nitric oxide synthase were reduced and increased, respectively. In summary, walnut consumption was accompanied with moderate beneficial vascular effect in healthy rats, while an effect of walnut in rats with metabolic disturbances was rather controversial.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Food Sciences & Nutrition
T1  - Beneficial effect of walnuts on vascular tone is associated with Akt signalling, voltage-dependent calcium channel LTCC and ATP-sensitive potassium channel Kv1.2
DO  - 10.1080/09637486.2020.1796931
ER  - 

@article{
author = "Stanisić, Jelena and Ivković, Tamara and Romić, Snježana and Zec, Manja M. and Culafić, Tijana and Stojiljković, Mojca and Korićanac, Goran",
year = "2020",
abstract = "Consumption of walnuts is beneficial for cardiovascular health. To study walnut effects on proteins involved in vascular tone regulation, control and fructose-fed rats were subjected to walnut diet for 6 weeks. In contrast with increased energy intake and body mass gain, aortic protein level of L-type calcium channel alpha subunit was decreased and the level of SUR2B subunit of ATP-sensitive K + channel was increased in healthy rats subjected to walnuts, together with improved Akt phosphorylation. Upon the walnut diet in rats subjected to fructose overload, the rise in energy intake and body mass gain, was followed by an increase in blood insulin. Although SUR2B level was elevated, the level of sodium-calcium exchanger NCX1 and inducible nitric oxide synthase were reduced and increased, respectively. In summary, walnut consumption was accompanied with moderate beneficial vascular effect in healthy rats, while an effect of walnut in rats with metabolic disturbances was rather controversial.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Food Sciences & Nutrition",
title = "Beneficial effect of walnuts on vascular tone is associated with Akt signalling, voltage-dependent calcium channel LTCC and ATP-sensitive potassium channel Kv1.2",
doi = "10.1080/09637486.2020.1796931"
}

Stanisić, J., Ivković, T., Romić, S., Zec, M. M., Culafić, T., Stojiljković, M.,& Korićanac, G.. (2020). Beneficial effect of walnuts on vascular tone is associated with Akt signalling, voltage-dependent calcium channel LTCC and ATP-sensitive potassium channel Kv1.2. in International Journal of Food Sciences & Nutrition
Taylor & Francis Ltd, Abingdon..
https://doi.org/10.1080/09637486.2020.1796931

Stanisić J, Ivković T, Romić S, Zec MM, Culafić T, Stojiljković M, Korićanac G. Beneficial effect of walnuts on vascular tone is associated with Akt signalling, voltage-dependent calcium channel LTCC and ATP-sensitive potassium channel Kv1.2. in International Journal of Food Sciences & Nutrition. 2020;.
doi:10.1080/09637486.2020.1796931 .

Stanisić, Jelena, Ivković, Tamara, Romić, Snježana, Zec, Manja M., Culafić, Tijana, Stojiljković, Mojca, Korićanac, Goran, "Beneficial effect of walnuts on vascular tone is associated with Akt signalling, voltage-dependent calcium channel LTCC and ATP-sensitive potassium channel Kv1.2" in International Journal of Food Sciences & Nutrition (2020),
https://doi.org/10.1080/09637486.2020.1796931 . .