TY  - JOUR
AU  - Molina-Montes, Esther
AU  - Uzhova, Irina
AU  - Verardo, Vito
AU  - Artacho, Reyes
AU  - García-Villanova, Belén
AU  - Jesús Guerra-Hernández, Eduardo
AU  - Kapsokefalou, Maria
AU  - Malisova, Olga
AU  - Vlassopoulos, Antonis
AU  - Katidi, Alexandra
AU  - Koroušić-Seljak, Barbara
AU  - Modic, Robert
AU  - Eftimov, Tome
AU  - Hren, Irena
AU  - Valenčič, Eva
AU  - Šatalić, Zvonimir
AU  - Panjkota Krbavčić, Ines
AU  - Vranešić Bender, Darija
AU  - Giacalone, Davide
AU  - Bom Frøst, Michael
AU  - Konić-Ristić, Aleksandra
AU  - Milešević, Jelena
AU  - Nikolić, Marina
AU  - Kolay, Ezgi
AU  - Güney, Merve
AU  - Kriaucioniene, Vilma
AU  - Czlapka-Matyasik, Magdalena
AU  - Bykowska-Derda, Aleksandra
AU  - Kujundžić, Enisa
AU  - Taljić, Irzada
AU  - Brka, Muhamed
AU  - Spiroski, Igor
AU  - Cunha Velho, Sérgio
AU  - Patrícia Sousa Pinto, Sofia
AU  - Nascimento Monteiro, Inês
AU  - Adriana Pereira, Janice
AU  - Dolores Ruíz-López, María
AU  - Rodríguez-Pérez, Celia
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1199
AB  - We aimed to evaluate the changes in eating behaviours of the adult population across 16 European countries due to the COVID-19 confinement and to evaluate whether these changes were somehow related to the severity of the containment measures applied in each country. An anonymous online self-reported questionnaire on socio-demographic characteristics, validated 14-items Mediterranean diet (MedDiet) Adherence Screener (MEDAS) as a reference of a healthy diet, eating and lifestyle behaviours prior to and during the COVID-19 confinement was used to collect data. The study included an adult population residing in 16 European countries at the time of the survey. Aggregated Stringency Index (SI) score, based on data from the Oxford COVID-19 Government Response Tracker, was calculated for each country at the time the questionnaire was distributed (range: 0–100). A total of 36,185 participants completed the questionnaire (77.6% female, 75.2% with high educational level and 42.7% aged between 21 and 35 years). In comparison to pre-confinement, a significantly higher adherence to the MedDiet during the confinement was observed across all countries (overall MEDAS score prior to- and during confinement: 5.23 ± 2.06 vs. 6.15 ± 2.06; p < 0.001), with the largest increase seen in Greece and North Macedonia. The highest adherence to MedDiet during confinement was found in Spain and Portugal (7.18 ± 1.84 and 7.34 ± 1.95, respectively). Stricter contingency restrictions seemed to lead to a significantly higher increase in the adherence to the MedDiet. The findings from this cross-sectional study could be used to inform current diet-related public health guidelines to ensure optimal nutrition is followed among the population, which in turn would help to alleviate the current public health crisis.
PB  - Elsevier
T2  - Food Quality and Preference
T1  - Impact of COVID-19 confinement on eating behaviours across 16 European countries: The COVIDiet cross-national study
SP  - 104231
VL  - 93
DO  - 10.1016/j.foodqual.2021.104231
ER  - 

@article{
author = "Molina-Montes, Esther and Uzhova, Irina and Verardo, Vito and Artacho, Reyes and García-Villanova, Belén and Jesús Guerra-Hernández, Eduardo and Kapsokefalou, Maria and Malisova, Olga and Vlassopoulos, Antonis and Katidi, Alexandra and Koroušić-Seljak, Barbara and Modic, Robert and Eftimov, Tome and Hren, Irena and Valenčič, Eva and Šatalić, Zvonimir and Panjkota Krbavčić, Ines and Vranešić Bender, Darija and Giacalone, Davide and Bom Frøst, Michael and Konić-Ristić, Aleksandra and Milešević, Jelena and Nikolić, Marina and Kolay, Ezgi and Güney, Merve and Kriaucioniene, Vilma and Czlapka-Matyasik, Magdalena and Bykowska-Derda, Aleksandra and Kujundžić, Enisa and Taljić, Irzada and Brka, Muhamed and Spiroski, Igor and Cunha Velho, Sérgio and Patrícia Sousa Pinto, Sofia and Nascimento Monteiro, Inês and Adriana Pereira, Janice and Dolores Ruíz-López, María and Rodríguez-Pérez, Celia",
year = "2021",
abstract = "We aimed to evaluate the changes in eating behaviours of the adult population across 16 European countries due to the COVID-19 confinement and to evaluate whether these changes were somehow related to the severity of the containment measures applied in each country. An anonymous online self-reported questionnaire on socio-demographic characteristics, validated 14-items Mediterranean diet (MedDiet) Adherence Screener (MEDAS) as a reference of a healthy diet, eating and lifestyle behaviours prior to and during the COVID-19 confinement was used to collect data. The study included an adult population residing in 16 European countries at the time of the survey. Aggregated Stringency Index (SI) score, based on data from the Oxford COVID-19 Government Response Tracker, was calculated for each country at the time the questionnaire was distributed (range: 0–100). A total of 36,185 participants completed the questionnaire (77.6% female, 75.2% with high educational level and 42.7% aged between 21 and 35 years). In comparison to pre-confinement, a significantly higher adherence to the MedDiet during the confinement was observed across all countries (overall MEDAS score prior to- and during confinement: 5.23 ± 2.06 vs. 6.15 ± 2.06; p < 0.001), with the largest increase seen in Greece and North Macedonia. The highest adherence to MedDiet during confinement was found in Spain and Portugal (7.18 ± 1.84 and 7.34 ± 1.95, respectively). Stricter contingency restrictions seemed to lead to a significantly higher increase in the adherence to the MedDiet. The findings from this cross-sectional study could be used to inform current diet-related public health guidelines to ensure optimal nutrition is followed among the population, which in turn would help to alleviate the current public health crisis.",
publisher = "Elsevier",
journal = "Food Quality and Preference",
title = "Impact of COVID-19 confinement on eating behaviours across 16 European countries: The COVIDiet cross-national study",
pages = "104231",
volume = "93",
doi = "10.1016/j.foodqual.2021.104231"
}

Molina-Montes, E., Uzhova, I., Verardo, V., Artacho, R., García-Villanova, B., Jesús Guerra-Hernández, E., Kapsokefalou, M., Malisova, O., Vlassopoulos, A., Katidi, A., Koroušić-Seljak, B., Modic, R., Eftimov, T., Hren, I., Valenčič, E., Šatalić, Z., Panjkota Krbavčić, I., Vranešić Bender, D., Giacalone, D., Bom Frøst, M., Konić-Ristić, A., Milešević, J., Nikolić, M., Kolay, E., Güney, M., Kriaucioniene, V., Czlapka-Matyasik, M., Bykowska-Derda, A., Kujundžić, E., Taljić, I., Brka, M., Spiroski, I., Cunha Velho, S., Patrícia Sousa Pinto, S., Nascimento Monteiro, I., Adriana Pereira, J., Dolores Ruíz-López, M.,& Rodríguez-Pérez, C.. (2021). Impact of COVID-19 confinement on eating behaviours across 16 European countries: The COVIDiet cross-national study. in Food Quality and Preference
Elsevier., 93, 104231.
https://doi.org/10.1016/j.foodqual.2021.104231

Molina-Montes E, Uzhova I, Verardo V, Artacho R, García-Villanova B, Jesús Guerra-Hernández E, Kapsokefalou M, Malisova O, Vlassopoulos A, Katidi A, Koroušić-Seljak B, Modic R, Eftimov T, Hren I, Valenčič E, Šatalić Z, Panjkota Krbavčić I, Vranešić Bender D, Giacalone D, Bom Frøst M, Konić-Ristić A, Milešević J, Nikolić M, Kolay E, Güney M, Kriaucioniene V, Czlapka-Matyasik M, Bykowska-Derda A, Kujundžić E, Taljić I, Brka M, Spiroski I, Cunha Velho S, Patrícia Sousa Pinto S, Nascimento Monteiro I, Adriana Pereira J, Dolores Ruíz-López M, Rodríguez-Pérez C. Impact of COVID-19 confinement on eating behaviours across 16 European countries: The COVIDiet cross-national study. in Food Quality and Preference. 2021;93:104231.
doi:10.1016/j.foodqual.2021.104231 .

Molina-Montes, Esther, Uzhova, Irina, Verardo, Vito, Artacho, Reyes, García-Villanova, Belén, Jesús Guerra-Hernández, Eduardo, Kapsokefalou, Maria, Malisova, Olga, Vlassopoulos, Antonis, Katidi, Alexandra, Koroušić-Seljak, Barbara, Modic, Robert, Eftimov, Tome, Hren, Irena, Valenčič, Eva, Šatalić, Zvonimir, Panjkota Krbavčić, Ines, Vranešić Bender, Darija, Giacalone, Davide, Bom Frøst, Michael, Konić-Ristić, Aleksandra, Milešević, Jelena, Nikolić, Marina, Kolay, Ezgi, Güney, Merve, Kriaucioniene, Vilma, Czlapka-Matyasik, Magdalena, Bykowska-Derda, Aleksandra, Kujundžić, Enisa, Taljić, Irzada, Brka, Muhamed, Spiroski, Igor, Cunha Velho, Sérgio, Patrícia Sousa Pinto, Sofia, Nascimento Monteiro, Inês, Adriana Pereira, Janice, Dolores Ruíz-López, María, Rodríguez-Pérez, Celia, "Impact of COVID-19 confinement on eating behaviours across 16 European countries: The COVIDiet cross-national study" in Food Quality and Preference, 93 (2021):104231,
https://doi.org/10.1016/j.foodqual.2021.104231 . .

TY  - JOUR
AU  - Pokimica, Biljana
AU  - Garcia-Conesa, Maria-Teresa
AU  - Zec, Manja M.
AU  - Debeljak-Martačić, Jasmina
AU  - Ranković, Slavica G.
AU  - Vidović, Nevena Đ.
AU  - Petrović-Oggiano, Gordana P.
AU  - Konić-Ristić, Aleksandra
AU  - Glibetić, Marija
PY  - 2019
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/977
AB  - Chokeberry polyphenols have been suggested to reduce cholesterol and blood pressure and thus protect against cardiovascular diseases (CVD), but the evidence in humans is limited and inconsistent. This randomized double-blinded three-parallel groups trial investigated the changes in various anthropometric and clinical biomarkers, and in plasma phospholipids fatty acids (PPFA) in volunteers at cardiovascular risk after a four-week intervention with 100 mL/day of (1) chokeberry juice with a high-dose of polyphenols (1177.11 mg gallic acid equivalents, GAE); (2) chokeberry juice with a low-dose of polyphenols (294.28 mg GAE) and; (3) a nutritionally matched polyphenol-free placebo drink. Our results indicate that the intake of chokeberry juice containing either the low or the high dose of polyphenols cannot be linked with a reduction in total- and low-density lipoprotein (LDL)cholesterol or in systolic (SBP) and diastolic (DBP) blood pressure in comparison with the consumption of the placebo drink. However, we found evidence of moderate changes in the PPFA, i.e., increased saturated fatty acids (SFA), mostly palmitic acid, and reduced n-6 polyunsaturated fatty acids (PUFA), principally linoleic acid (LA) with the intake of chokeberry against the placebo. These effects may be associated with the polyphenols but we could not differentiate a clear dose-response effect. Further research is still needed to elucidate the contribution of the polyphenolic fraction to the potential cardiovascular effects of the chokeberry and to build up the evidence of its potential benefit via the modulation of PPFA composition.
PB  - MDPI, Basel
T2  - Nutrients
T1  - Chokeberry Juice Containing Polyphenols Does Not Affect Cholesterol or Blood Pressure but Modifies the Composition of Plasma Phospholipids Fatty Acids in Individuals at Cardiovascular Risk
IS  - 4
VL  - 11
DO  - 10.3390/nu11040850
ER  - 

@article{
author = "Pokimica, Biljana and Garcia-Conesa, Maria-Teresa and Zec, Manja M. and Debeljak-Martačić, Jasmina and Ranković, Slavica G. and Vidović, Nevena Đ. and Petrović-Oggiano, Gordana P. and Konić-Ristić, Aleksandra and Glibetić, Marija",
year = "2019",
abstract = "Chokeberry polyphenols have been suggested to reduce cholesterol and blood pressure and thus protect against cardiovascular diseases (CVD), but the evidence in humans is limited and inconsistent. This randomized double-blinded three-parallel groups trial investigated the changes in various anthropometric and clinical biomarkers, and in plasma phospholipids fatty acids (PPFA) in volunteers at cardiovascular risk after a four-week intervention with 100 mL/day of (1) chokeberry juice with a high-dose of polyphenols (1177.11 mg gallic acid equivalents, GAE); (2) chokeberry juice with a low-dose of polyphenols (294.28 mg GAE) and; (3) a nutritionally matched polyphenol-free placebo drink. Our results indicate that the intake of chokeberry juice containing either the low or the high dose of polyphenols cannot be linked with a reduction in total- and low-density lipoprotein (LDL)cholesterol or in systolic (SBP) and diastolic (DBP) blood pressure in comparison with the consumption of the placebo drink. However, we found evidence of moderate changes in the PPFA, i.e., increased saturated fatty acids (SFA), mostly palmitic acid, and reduced n-6 polyunsaturated fatty acids (PUFA), principally linoleic acid (LA) with the intake of chokeberry against the placebo. These effects may be associated with the polyphenols but we could not differentiate a clear dose-response effect. Further research is still needed to elucidate the contribution of the polyphenolic fraction to the potential cardiovascular effects of the chokeberry and to build up the evidence of its potential benefit via the modulation of PPFA composition.",
publisher = "MDPI, Basel",
journal = "Nutrients",
title = "Chokeberry Juice Containing Polyphenols Does Not Affect Cholesterol or Blood Pressure but Modifies the Composition of Plasma Phospholipids Fatty Acids in Individuals at Cardiovascular Risk",
number = "4",
volume = "11",
doi = "10.3390/nu11040850"
}

Pokimica, B., Garcia-Conesa, M., Zec, M. M., Debeljak-Martačić, J., Ranković, S. G., Vidović, N. Đ., Petrović-Oggiano, G. P., Konić-Ristić, A.,& Glibetić, M.. (2019). Chokeberry Juice Containing Polyphenols Does Not Affect Cholesterol or Blood Pressure but Modifies the Composition of Plasma Phospholipids Fatty Acids in Individuals at Cardiovascular Risk. in Nutrients
MDPI, Basel., 11(4).
https://doi.org/10.3390/nu11040850

Pokimica B, Garcia-Conesa M, Zec MM, Debeljak-Martačić J, Ranković SG, Vidović NĐ, Petrović-Oggiano GP, Konić-Ristić A, Glibetić M. Chokeberry Juice Containing Polyphenols Does Not Affect Cholesterol or Blood Pressure but Modifies the Composition of Plasma Phospholipids Fatty Acids in Individuals at Cardiovascular Risk. in Nutrients. 2019;11(4).
doi:10.3390/nu11040850 .

Pokimica, Biljana, Garcia-Conesa, Maria-Teresa, Zec, Manja M., Debeljak-Martačić, Jasmina, Ranković, Slavica G., Vidović, Nevena Đ., Petrović-Oggiano, Gordana P., Konić-Ristić, Aleksandra, Glibetić, Marija, "Chokeberry Juice Containing Polyphenols Does Not Affect Cholesterol or Blood Pressure but Modifies the Composition of Plasma Phospholipids Fatty Acids in Individuals at Cardiovascular Risk" in Nutrients, 11, no. 4 (2019),
https://doi.org/10.3390/nu11040850 . .

TY  - JOUR
AU  - Nikolić, Marina
AU  - Konić-Ristić, Aleksandra
AU  - Gonzalez-Sarrias, Antonio
AU  - Istas, Geoffrey
AU  - Urpi-Sarda, Mireia
AU  - Dall'Asta, Margherita
AU  - Monfoulet, Laurent-Emanuel
AU  - Cloetens, Lieselotte
AU  - Bayram, Banu
AU  - Tumolo, Maria Rosaria
AU  - Chervenkov, Mihail
AU  - Scoditti, Egeria
AU  - Massaro, Marika
AU  - Tejera, Noemi
AU  - Abadjieva, Desislava
AU  - Chambers, Karen
AU  - Krga, Irena
AU  - Tomas-Barberan, Francisco A.
AU  - Morand, Christine
AU  - Feliciano, Rodrigo
AU  - Garcia-Villalba, Rocio
AU  - Garcia-Aloy, Mar
AU  - Mena, Pedro
PY  - 2019
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/933
AB  - Key messages The reporting quality of human studies on inter-individual variation in response to plant bioactives is generally low and should be significantly improved. There is no specific guidance for reporting studies on inter-individual variation in response to plant bioactives. The assessment of reporting quality using a scale approach is considered a valuable tool in assessing compliance with the recommendations in the submission phase or during the reviewing process. It also provides a quantitative measure of the quality of studies to be used in meta-analysis. Eleven reporting criteria were developed and supported by detailed definitions and guidance for their scoring. The POSITIVe quality index was tested and demonstrated to be valid, reliable, and responsive. The use of the quality index and its supporting explanatory material (dictionary) as a guide for researchers, peer-reviewers, and journal editors will foster further complete and transparent reporting of data on inter-individual variability. The criteria used in the quality index can serve as additional guidance to inform the design and conduction of further studies on inter-individual variations in response to plant bioactives. Better reporting is expected to lead to a better understanding of the mechanisms and factors involved and thus better study designs with greater impact on policies and practice. Purpose The quality of the study design and data reporting in human trials dealing with the inter-individual variability in response to the consumption of plant bioactives is, in general, low. There is a lack of recommendations supporting the scientific community on this topic. This study aimed at developing a quality index to assist the assessment of the reporting quality of intervention trials addressing the inter-individual variability in response to plant bioactive consumption. Recommendations for better designing and reporting studies were discussed. Methods The selection of the parameters used for the development of the quality index was carried out in agreement with the scientific community through a survey. Parameters were defined, grouped into categories, and scored for different quality levels. The applicability of the scoring system was tested in terms of consistency and effort, and its validity was assessed by comparison with a simultaneous evaluation by experts' criteria. Results The "POSITIVe quality index" included 11 reporting criteria grouped into four categories (Statistics, Reporting, Data presentation, and Individual data availability). It was supported by detailed definitions and guidance for their scoring. The quality index score was tested, and the index demonstrated to be valid, reliable, and responsive. Conclusions The evaluation of the reporting quality of studies addressing inter-individual variability in response to plant bioactives highlighted the aspects requiring major improvements. Specific tools and recommendations favoring a complete and transparent reporting on inter-individual variability have been provided to support the scientific community on this field.
PB  - Springer Heidelberg, Heidelberg
T2  - European Journal of Nutrition
T1  - Improving the reporting quality of intervention trials addressing the inter-individual variability in response to the consumption of plant bioactives: quality index and recommendations
EP  - S64
SP  - S49
VL  - 58
DO  - 10.1007/s00394-019-02069-3
ER  - 

@article{
author = "Nikolić, Marina and Konić-Ristić, Aleksandra and Gonzalez-Sarrias, Antonio and Istas, Geoffrey and Urpi-Sarda, Mireia and Dall'Asta, Margherita and Monfoulet, Laurent-Emanuel and Cloetens, Lieselotte and Bayram, Banu and Tumolo, Maria Rosaria and Chervenkov, Mihail and Scoditti, Egeria and Massaro, Marika and Tejera, Noemi and Abadjieva, Desislava and Chambers, Karen and Krga, Irena and Tomas-Barberan, Francisco A. and Morand, Christine and Feliciano, Rodrigo and Garcia-Villalba, Rocio and Garcia-Aloy, Mar and Mena, Pedro",
year = "2019",
abstract = "Key messages The reporting quality of human studies on inter-individual variation in response to plant bioactives is generally low and should be significantly improved. There is no specific guidance for reporting studies on inter-individual variation in response to plant bioactives. The assessment of reporting quality using a scale approach is considered a valuable tool in assessing compliance with the recommendations in the submission phase or during the reviewing process. It also provides a quantitative measure of the quality of studies to be used in meta-analysis. Eleven reporting criteria were developed and supported by detailed definitions and guidance for their scoring. The POSITIVe quality index was tested and demonstrated to be valid, reliable, and responsive. The use of the quality index and its supporting explanatory material (dictionary) as a guide for researchers, peer-reviewers, and journal editors will foster further complete and transparent reporting of data on inter-individual variability. The criteria used in the quality index can serve as additional guidance to inform the design and conduction of further studies on inter-individual variations in response to plant bioactives. Better reporting is expected to lead to a better understanding of the mechanisms and factors involved and thus better study designs with greater impact on policies and practice. Purpose The quality of the study design and data reporting in human trials dealing with the inter-individual variability in response to the consumption of plant bioactives is, in general, low. There is a lack of recommendations supporting the scientific community on this topic. This study aimed at developing a quality index to assist the assessment of the reporting quality of intervention trials addressing the inter-individual variability in response to plant bioactive consumption. Recommendations for better designing and reporting studies were discussed. Methods The selection of the parameters used for the development of the quality index was carried out in agreement with the scientific community through a survey. Parameters were defined, grouped into categories, and scored for different quality levels. The applicability of the scoring system was tested in terms of consistency and effort, and its validity was assessed by comparison with a simultaneous evaluation by experts' criteria. Results The "POSITIVe quality index" included 11 reporting criteria grouped into four categories (Statistics, Reporting, Data presentation, and Individual data availability). It was supported by detailed definitions and guidance for their scoring. The quality index score was tested, and the index demonstrated to be valid, reliable, and responsive. Conclusions The evaluation of the reporting quality of studies addressing inter-individual variability in response to plant bioactives highlighted the aspects requiring major improvements. Specific tools and recommendations favoring a complete and transparent reporting on inter-individual variability have been provided to support the scientific community on this field.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "European Journal of Nutrition",
title = "Improving the reporting quality of intervention trials addressing the inter-individual variability in response to the consumption of plant bioactives: quality index and recommendations",
pages = "S64-S49",
volume = "58",
doi = "10.1007/s00394-019-02069-3"
}

Nikolić, M., Konić-Ristić, A., Gonzalez-Sarrias, A., Istas, G., Urpi-Sarda, M., Dall'Asta, M., Monfoulet, L., Cloetens, L., Bayram, B., Tumolo, M. R., Chervenkov, M., Scoditti, E., Massaro, M., Tejera, N., Abadjieva, D., Chambers, K., Krga, I., Tomas-Barberan, F. A., Morand, C., Feliciano, R., Garcia-Villalba, R., Garcia-Aloy, M.,& Mena, P.. (2019). Improving the reporting quality of intervention trials addressing the inter-individual variability in response to the consumption of plant bioactives: quality index and recommendations. in European Journal of Nutrition
Springer Heidelberg, Heidelberg., 58, S49-S64.
https://doi.org/10.1007/s00394-019-02069-3

Nikolić M, Konić-Ristić A, Gonzalez-Sarrias A, Istas G, Urpi-Sarda M, Dall'Asta M, Monfoulet L, Cloetens L, Bayram B, Tumolo MR, Chervenkov M, Scoditti E, Massaro M, Tejera N, Abadjieva D, Chambers K, Krga I, Tomas-Barberan FA, Morand C, Feliciano R, Garcia-Villalba R, Garcia-Aloy M, Mena P. Improving the reporting quality of intervention trials addressing the inter-individual variability in response to the consumption of plant bioactives: quality index and recommendations. in European Journal of Nutrition. 2019;58:S49-S64.
doi:10.1007/s00394-019-02069-3 .

Nikolić, Marina, Konić-Ristić, Aleksandra, Gonzalez-Sarrias, Antonio, Istas, Geoffrey, Urpi-Sarda, Mireia, Dall'Asta, Margherita, Monfoulet, Laurent-Emanuel, Cloetens, Lieselotte, Bayram, Banu, Tumolo, Maria Rosaria, Chervenkov, Mihail, Scoditti, Egeria, Massaro, Marika, Tejera, Noemi, Abadjieva, Desislava, Chambers, Karen, Krga, Irena, Tomas-Barberan, Francisco A., Morand, Christine, Feliciano, Rodrigo, Garcia-Villalba, Rocio, Garcia-Aloy, Mar, Mena, Pedro, "Improving the reporting quality of intervention trials addressing the inter-individual variability in response to the consumption of plant bioactives: quality index and recommendations" in European Journal of Nutrition, 58 (2019):S49-S64,
https://doi.org/10.1007/s00394-019-02069-3 . .

TY  - JOUR
AU  - Srdić-Rajić, Tatjana
AU  - Santibanez, Juan F.
AU  - Kanjer, Ksenija
AU  - Tišma-Miletić, Nevena
AU  - Cavić, Milena
AU  - Galun, Daniel
AU  - Jevrić, Marko
AU  - Kardum, Nevena Đ.
AU  - Konić-Ristić, Aleksandra
AU  - Zoranović, Tamara
PY  - 2018
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/859
PB  - Nature Publishing Group, London
T2  - Scientific Reports
T1  - Iscador Qu inhibits doxorubicin-induced senescence of MCF7 cells (vol 7, 3763, 2017)
VL  - 8
DO  - 10.1038/s41598-018-31450-1
ER  - 

@article{
author = "Srdić-Rajić, Tatjana and Santibanez, Juan F. and Kanjer, Ksenija and Tišma-Miletić, Nevena and Cavić, Milena and Galun, Daniel and Jevrić, Marko and Kardum, Nevena Đ. and Konić-Ristić, Aleksandra and Zoranović, Tamara",
year = "2018",
publisher = "Nature Publishing Group, London",
journal = "Scientific Reports",
title = "Iscador Qu inhibits doxorubicin-induced senescence of MCF7 cells (vol 7, 3763, 2017)",
volume = "8",
doi = "10.1038/s41598-018-31450-1"
}

Srdić-Rajić, T., Santibanez, J. F., Kanjer, K., Tišma-Miletić, N., Cavić, M., Galun, D., Jevrić, M., Kardum, N. Đ., Konić-Ristić, A.,& Zoranović, T.. (2018). Iscador Qu inhibits doxorubicin-induced senescence of MCF7 cells (vol 7, 3763, 2017). in Scientific Reports
Nature Publishing Group, London., 8.
https://doi.org/10.1038/s41598-018-31450-1

Srdić-Rajić T, Santibanez JF, Kanjer K, Tišma-Miletić N, Cavić M, Galun D, Jevrić M, Kardum NĐ, Konić-Ristić A, Zoranović T. Iscador Qu inhibits doxorubicin-induced senescence of MCF7 cells (vol 7, 3763, 2017). in Scientific Reports. 2018;8.
doi:10.1038/s41598-018-31450-1 .

Srdić-Rajić, Tatjana, Santibanez, Juan F., Kanjer, Ksenija, Tišma-Miletić, Nevena, Cavić, Milena, Galun, Daniel, Jevrić, Marko, Kardum, Nevena Đ., Konić-Ristić, Aleksandra, Zoranović, Tamara, "Iscador Qu inhibits doxorubicin-induced senescence of MCF7 cells (vol 7, 3763, 2017)" in Scientific Reports, 8 (2018),
https://doi.org/10.1038/s41598-018-31450-1 . .

TY  - JOUR
AU  - Krga, Irena
AU  - Vidović, Nevena Đ.
AU  - Milenković, Dragan
AU  - Konić-Ristić, Aleksandra
AU  - Stojanović, Filip
AU  - Morand, Christine
AU  - Glibetić, Marija
PY  - 2018
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/841
AB  - Accumulating evidence suggests that anthocyanins play an important role in the cardioprotective effects associated with consumption of anthocyanin-rich foods. These benefits may partly be attributed to their effects on platelets, significant contributors to cardiovascular disease development. This study aimed to investigate the impact of physiologically relevant concentrations of anthocyanins and their metabolites on platelet activation and platelet-leukocyte aggregation. Whole blood from seven healthy volunteers was treated with anthocyanins: cyanidin-3-arabinoside, cyanidin-3-glucoside, cyanidin-3-galactoside, delphinidin-3-glucoside and peonidin-3-glucoside at 0.1 mu M concentration or gut metabolites: 4-hydroxybenzaldehyde, protocatechuic, vanillic, ferulic and hippuric acids at 0.5 mu M, 0.2 mu M, 2 mu M, 1 mu M, 2 mu M concentration, respectively. Markers of adenosine diphosphate-induced platelet activation (P-selectin and GPIIb-IIIa expression) and platelet-monocyte and platelet-neutrophil aggregation were analyzed using flow cytometry. Cyanidin-3-arabinoside, delphinidin-3-glucoside, and peonidin-3-glucoside decreased agonist-induced P-selectin expression, while cyanidin-3-galactoside and cyanidin-3-arabinoside reduced platelet-neutrophil aggregation. Hippuric and protocatechuic acids inhibited P-selectin expression, ferulic acid reduced platelet-monocyte aggregation, while 4-hydroxybenzaldehyde affected P-selectin expression, platelet-neutrophil and monocyte aggregation. Only cyanidin-3-glucoside and protocatechuic acid decreased GPIIb-IIIa expression. These results demonstrate the bioactivity of anthocyanins and their gut metabolites at physiologically relevant concentrations on platelet function and interaction with leukocytes, presenting mechanisms by which they contribute to the beneficial effects of habitual consumption of anthocyanin-rich foods on cardiovascular health.
PB  - Elsevier Science Inc, New York
T2  - Archives of Biochemistry & Biophysics
T1  - Effects of anthocyanins and their gut metabolites on adenosine diphosphate-induced platelet activation and their aggregation with monocytes and neutrophils
EP  - 41
SP  - 34
VL  - 645
DO  - 10.1016/j.abb.2018.03.016
ER  - 

@article{
author = "Krga, Irena and Vidović, Nevena Đ. and Milenković, Dragan and Konić-Ristić, Aleksandra and Stojanović, Filip and Morand, Christine and Glibetić, Marija",
year = "2018",
abstract = "Accumulating evidence suggests that anthocyanins play an important role in the cardioprotective effects associated with consumption of anthocyanin-rich foods. These benefits may partly be attributed to their effects on platelets, significant contributors to cardiovascular disease development. This study aimed to investigate the impact of physiologically relevant concentrations of anthocyanins and their metabolites on platelet activation and platelet-leukocyte aggregation. Whole blood from seven healthy volunteers was treated with anthocyanins: cyanidin-3-arabinoside, cyanidin-3-glucoside, cyanidin-3-galactoside, delphinidin-3-glucoside and peonidin-3-glucoside at 0.1 mu M concentration or gut metabolites: 4-hydroxybenzaldehyde, protocatechuic, vanillic, ferulic and hippuric acids at 0.5 mu M, 0.2 mu M, 2 mu M, 1 mu M, 2 mu M concentration, respectively. Markers of adenosine diphosphate-induced platelet activation (P-selectin and GPIIb-IIIa expression) and platelet-monocyte and platelet-neutrophil aggregation were analyzed using flow cytometry. Cyanidin-3-arabinoside, delphinidin-3-glucoside, and peonidin-3-glucoside decreased agonist-induced P-selectin expression, while cyanidin-3-galactoside and cyanidin-3-arabinoside reduced platelet-neutrophil aggregation. Hippuric and protocatechuic acids inhibited P-selectin expression, ferulic acid reduced platelet-monocyte aggregation, while 4-hydroxybenzaldehyde affected P-selectin expression, platelet-neutrophil and monocyte aggregation. Only cyanidin-3-glucoside and protocatechuic acid decreased GPIIb-IIIa expression. These results demonstrate the bioactivity of anthocyanins and their gut metabolites at physiologically relevant concentrations on platelet function and interaction with leukocytes, presenting mechanisms by which they contribute to the beneficial effects of habitual consumption of anthocyanin-rich foods on cardiovascular health.",
publisher = "Elsevier Science Inc, New York",
journal = "Archives of Biochemistry & Biophysics",
title = "Effects of anthocyanins and their gut metabolites on adenosine diphosphate-induced platelet activation and their aggregation with monocytes and neutrophils",
pages = "41-34",
volume = "645",
doi = "10.1016/j.abb.2018.03.016"
}

Krga, I., Vidović, N. Đ., Milenković, D., Konić-Ristić, A., Stojanović, F., Morand, C.,& Glibetić, M.. (2018). Effects of anthocyanins and their gut metabolites on adenosine diphosphate-induced platelet activation and their aggregation with monocytes and neutrophils. in Archives of Biochemistry & Biophysics
Elsevier Science Inc, New York., 645, 34-41.
https://doi.org/10.1016/j.abb.2018.03.016

Krga I, Vidović NĐ, Milenković D, Konić-Ristić A, Stojanović F, Morand C, Glibetić M. Effects of anthocyanins and their gut metabolites on adenosine diphosphate-induced platelet activation and their aggregation with monocytes and neutrophils. in Archives of Biochemistry & Biophysics. 2018;645:34-41.
doi:10.1016/j.abb.2018.03.016 .

Krga, Irena, Vidović, Nevena Đ., Milenković, Dragan, Konić-Ristić, Aleksandra, Stojanović, Filip, Morand, Christine, Glibetić, Marija, "Effects of anthocyanins and their gut metabolites on adenosine diphosphate-induced platelet activation and their aggregation with monocytes and neutrophils" in Archives of Biochemistry & Biophysics, 645 (2018):34-41,
https://doi.org/10.1016/j.abb.2018.03.016 . .

TY  - JOUR
AU  - Kojadinović, Milica
AU  - Arsić, Aleksandra
AU  - Debeljak-Martačić, Jasmina
AU  - Konić-Ristić, Aleksandra
AU  - Kardum, Nevena Đ.
AU  - Popović, Tamara B.
AU  - Glibetić, Marija
PY  - 2017
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/798
AB  - BACKGROUNDPomegranate juice is a rich source of polyphenols and is thus a promising dietary antioxidant with numerous health-promoting effects. These include a beneficial impact on cardiovascular health that could be partly attributed to the effects of polyphenols on lipid metabolism. The aim of this study was to investigate whether consumption of pomegranate juice for 6 weeks could modify lipid peroxidation and phospholipid fatty acid composition of plasma and erythrocytes in subjects with metabolic syndrome. Twenty-three women, aged 40-60 years, were enrolled and randomly assigned into two groups: the intervention group, in which each participant consumed 300 mL of juice per day for 6 weeks; and a control group. RESULTSA statistically significant decrease in the relative amount of arachidonic acid (P  lt  0.05) and an increase in the relative amount of saturated fatty acids (P  lt  0.05) were observed in the intervention group at the end of the consumption period. In addition, pomegranate juice significantly increased the relative amount of total mono-unsaturated fatty acids (P  lt  0.05), and significantly decreased the levels of thiobarbituric acid reactive substances in erythrocytes (P  lt  0.05). The status of blood lipids and the values for blood pressure were not changed during the study. CONCLUSIONThe results obtained indicate a positive impact of the consumption of pomegranate juice on lipid peroxidation and fatty acid status in subjects with metabolic syndrome and suggest potential anti-inflammatory and cardio-protective effects.
PB  - Wiley, Hoboken
T2  - Journal of the Science of Food & Agriculture
T1  - Consumption of pomegranate juice decreases blood lipid peroxidation and levels of arachidonic acid in women with metabolic syndrome
EP  - 1804
IS  - 6
SP  - 1798
VL  - 97
DO  - 10.1002/jsfa.7977
ER  - 

@article{
author = "Kojadinović, Milica and Arsić, Aleksandra and Debeljak-Martačić, Jasmina and Konić-Ristić, Aleksandra and Kardum, Nevena Đ. and Popović, Tamara B. and Glibetić, Marija",
year = "2017",
abstract = "BACKGROUNDPomegranate juice is a rich source of polyphenols and is thus a promising dietary antioxidant with numerous health-promoting effects. These include a beneficial impact on cardiovascular health that could be partly attributed to the effects of polyphenols on lipid metabolism. The aim of this study was to investigate whether consumption of pomegranate juice for 6 weeks could modify lipid peroxidation and phospholipid fatty acid composition of plasma and erythrocytes in subjects with metabolic syndrome. Twenty-three women, aged 40-60 years, were enrolled and randomly assigned into two groups: the intervention group, in which each participant consumed 300 mL of juice per day for 6 weeks; and a control group. RESULTSA statistically significant decrease in the relative amount of arachidonic acid (P  lt  0.05) and an increase in the relative amount of saturated fatty acids (P  lt  0.05) were observed in the intervention group at the end of the consumption period. In addition, pomegranate juice significantly increased the relative amount of total mono-unsaturated fatty acids (P  lt  0.05), and significantly decreased the levels of thiobarbituric acid reactive substances in erythrocytes (P  lt  0.05). The status of blood lipids and the values for blood pressure were not changed during the study. CONCLUSIONThe results obtained indicate a positive impact of the consumption of pomegranate juice on lipid peroxidation and fatty acid status in subjects with metabolic syndrome and suggest potential anti-inflammatory and cardio-protective effects.",
publisher = "Wiley, Hoboken",
journal = "Journal of the Science of Food & Agriculture",
title = "Consumption of pomegranate juice decreases blood lipid peroxidation and levels of arachidonic acid in women with metabolic syndrome",
pages = "1804-1798",
number = "6",
volume = "97",
doi = "10.1002/jsfa.7977"
}

Kojadinović, M., Arsić, A., Debeljak-Martačić, J., Konić-Ristić, A., Kardum, N. Đ., Popović, T. B.,& Glibetić, M.. (2017). Consumption of pomegranate juice decreases blood lipid peroxidation and levels of arachidonic acid in women with metabolic syndrome. in Journal of the Science of Food & Agriculture
Wiley, Hoboken., 97(6), 1798-1804.
https://doi.org/10.1002/jsfa.7977

Kojadinović M, Arsić A, Debeljak-Martačić J, Konić-Ristić A, Kardum NĐ, Popović TB, Glibetić M. Consumption of pomegranate juice decreases blood lipid peroxidation and levels of arachidonic acid in women with metabolic syndrome. in Journal of the Science of Food & Agriculture. 2017;97(6):1798-1804.
doi:10.1002/jsfa.7977 .

Kojadinović, Milica, Arsić, Aleksandra, Debeljak-Martačić, Jasmina, Konić-Ristić, Aleksandra, Kardum, Nevena Đ., Popović, Tamara B., Glibetić, Marija, "Consumption of pomegranate juice decreases blood lipid peroxidation and levels of arachidonic acid in women with metabolic syndrome" in Journal of the Science of Food & Agriculture, 97, no. 6 (2017):1798-1804,
https://doi.org/10.1002/jsfa.7977 . .

TY  - JOUR
AU  - Kardum, Nevena Đ.
AU  - Konić-Ristić, Aleksandra
AU  - Zec, Manja M.
AU  - Kojadinović, Milica
AU  - Petrović-Oggiano, Gordana P.
AU  - Zeković, Milica
AU  - Kroon, Paul A.
AU  - Glibetić, Marija
PY  - 2017
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/782
AB  - Products suitable for use as controls in food interventions designed to demonstrate the role of minor components are largely lacking. In the present study, we aimed to develop a formulation to be used as a placebo in a clinical trial designed to assess the effects of aronia juice polyphenols on platelet function. Three formulations with the same nutrient composition as aronia juice were prepared by mixing various nutrients, artificial colours and flavours with water. The similarity of formulations to aronia juice in terms of taste, colour, smell and texture was assessed by six food panellists. The final placebo was tested for its impact on platelet function, biochemical and anthropometric parameters in a 4-week long study. No significant changes in platelet function, or in several cardiovascular and safety markers were recorded. Formulation suitable for use as a placebo for dietary intervention studies using aronia juice has been developed and demonstrated to be well tolerated in humans.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Food Sciences & Nutrition
T1  - Design, formulation and sensory evaluation of a polyphenol-rich food placebo: an example of aronia juice for food intervention studies
EP  - 749
IS  - 6
SP  - 742
VL  - 68
DO  - 10.1080/09637486.2017.1283682
ER  - 

@article{
author = "Kardum, Nevena Đ. and Konić-Ristić, Aleksandra and Zec, Manja M. and Kojadinović, Milica and Petrović-Oggiano, Gordana P. and Zeković, Milica and Kroon, Paul A. and Glibetić, Marija",
year = "2017",
abstract = "Products suitable for use as controls in food interventions designed to demonstrate the role of minor components are largely lacking. In the present study, we aimed to develop a formulation to be used as a placebo in a clinical trial designed to assess the effects of aronia juice polyphenols on platelet function. Three formulations with the same nutrient composition as aronia juice were prepared by mixing various nutrients, artificial colours and flavours with water. The similarity of formulations to aronia juice in terms of taste, colour, smell and texture was assessed by six food panellists. The final placebo was tested for its impact on platelet function, biochemical and anthropometric parameters in a 4-week long study. No significant changes in platelet function, or in several cardiovascular and safety markers were recorded. Formulation suitable for use as a placebo for dietary intervention studies using aronia juice has been developed and demonstrated to be well tolerated in humans.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Food Sciences & Nutrition",
title = "Design, formulation and sensory evaluation of a polyphenol-rich food placebo: an example of aronia juice for food intervention studies",
pages = "749-742",
number = "6",
volume = "68",
doi = "10.1080/09637486.2017.1283682"
}

Kardum, N. Đ., Konić-Ristić, A., Zec, M. M., Kojadinović, M., Petrović-Oggiano, G. P., Zeković, M., Kroon, P. A.,& Glibetić, M.. (2017). Design, formulation and sensory evaluation of a polyphenol-rich food placebo: an example of aronia juice for food intervention studies. in International Journal of Food Sciences & Nutrition
Taylor & Francis Ltd, Abingdon., 68(6), 742-749.
https://doi.org/10.1080/09637486.2017.1283682

Kardum NĐ, Konić-Ristić A, Zec MM, Kojadinović M, Petrović-Oggiano GP, Zeković M, Kroon PA, Glibetić M. Design, formulation and sensory evaluation of a polyphenol-rich food placebo: an example of aronia juice for food intervention studies. in International Journal of Food Sciences & Nutrition. 2017;68(6):742-749.
doi:10.1080/09637486.2017.1283682 .

Kardum, Nevena Đ., Konić-Ristić, Aleksandra, Zec, Manja M., Kojadinović, Milica, Petrović-Oggiano, Gordana P., Zeković, Milica, Kroon, Paul A., Glibetić, Marija, "Design, formulation and sensory evaluation of a polyphenol-rich food placebo: an example of aronia juice for food intervention studies" in International Journal of Food Sciences & Nutrition, 68, no. 6 (2017):742-749,
https://doi.org/10.1080/09637486.2017.1283682 . .

TY  - JOUR
AU  - Srdić-Rajić, Tatjana
AU  - Santibanez, Juan F.
AU  - Kanjer, Ksenija
AU  - Tišma-Miletić, Nevena
AU  - Cavić, Milena
AU  - Galun, Daniel
AU  - Jevrić, Marko
AU  - Kardum, Nevena Đ.
AU  - Konić-Ristić, Aleksandra
AU  - Zoranović, Tamara
PY  - 2017
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/819
AB  - Chemotherapy in patients with inoperable or advanced breast cancer inevitably results in low-dose exposure of tumor-cell subset and senescence. Metabolically active senescent cells secrete multiple tumor promoting factors making their elimination a therapeutic priority. Viscum album is one of the most widely used alternative anti-cancer medicines facilitating chemotherapy tolerance of breast cancer patients. The aim of this study was to model and investigate how Viscum album extracts execute additive anti-tumor activity with low-dose Dox using ER + MCF7 breast cancer cells. We report that cotreatment of MCF7 with Viscum album and Dox abrogates G2/M cycle arrest replacing senescence with intrinsic apoptotic program. Mechanistically, this switch was associated with down-regulation of p21, p53/p73 as well as Erk1/2 and p38 activation. Our findings, therefore, identify a novel mechanistic axis of additive antitumor activity of Viscum album and low dose-Dox. In conclusion, ER + breast cancer patients may benefit from addition of Viscum album to low-dose Dox chemotherapy due to suppression of cancer cell senescence and induction of apoptosis.
PB  - Nature Publishing Group, London
T2  - Scientific Reports
T1  - Iscador Qu inhibits doxorubicin-induced senescence of MCF7 cells
SP  - 3763
VL  - 7
DO  - 10.1038/s41598-017-03898-0
ER  - 

@article{
author = "Srdić-Rajić, Tatjana and Santibanez, Juan F. and Kanjer, Ksenija and Tišma-Miletić, Nevena and Cavić, Milena and Galun, Daniel and Jevrić, Marko and Kardum, Nevena Đ. and Konić-Ristić, Aleksandra and Zoranović, Tamara",
year = "2017",
abstract = "Chemotherapy in patients with inoperable or advanced breast cancer inevitably results in low-dose exposure of tumor-cell subset and senescence. Metabolically active senescent cells secrete multiple tumor promoting factors making their elimination a therapeutic priority. Viscum album is one of the most widely used alternative anti-cancer medicines facilitating chemotherapy tolerance of breast cancer patients. The aim of this study was to model and investigate how Viscum album extracts execute additive anti-tumor activity with low-dose Dox using ER + MCF7 breast cancer cells. We report that cotreatment of MCF7 with Viscum album and Dox abrogates G2/M cycle arrest replacing senescence with intrinsic apoptotic program. Mechanistically, this switch was associated with down-regulation of p21, p53/p73 as well as Erk1/2 and p38 activation. Our findings, therefore, identify a novel mechanistic axis of additive antitumor activity of Viscum album and low dose-Dox. In conclusion, ER + breast cancer patients may benefit from addition of Viscum album to low-dose Dox chemotherapy due to suppression of cancer cell senescence and induction of apoptosis.",
publisher = "Nature Publishing Group, London",
journal = "Scientific Reports",
title = "Iscador Qu inhibits doxorubicin-induced senescence of MCF7 cells",
pages = "3763",
volume = "7",
doi = "10.1038/s41598-017-03898-0"
}

Srdić-Rajić, T., Santibanez, J. F., Kanjer, K., Tišma-Miletić, N., Cavić, M., Galun, D., Jevrić, M., Kardum, N. Đ., Konić-Ristić, A.,& Zoranović, T.. (2017). Iscador Qu inhibits doxorubicin-induced senescence of MCF7 cells. in Scientific Reports
Nature Publishing Group, London., 7, 3763.
https://doi.org/10.1038/s41598-017-03898-0

Srdić-Rajić T, Santibanez JF, Kanjer K, Tišma-Miletić N, Cavić M, Galun D, Jevrić M, Kardum NĐ, Konić-Ristić A, Zoranović T. Iscador Qu inhibits doxorubicin-induced senescence of MCF7 cells. in Scientific Reports. 2017;7:3763.
doi:10.1038/s41598-017-03898-0 .

Srdić-Rajić, Tatjana, Santibanez, Juan F., Kanjer, Ksenija, Tišma-Miletić, Nevena, Cavić, Milena, Galun, Daniel, Jevrić, Marko, Kardum, Nevena Đ., Konić-Ristić, Aleksandra, Zoranović, Tamara, "Iscador Qu inhibits doxorubicin-induced senescence of MCF7 cells" in Scientific Reports, 7 (2017):3763,
https://doi.org/10.1038/s41598-017-03898-0 . .

TY  - JOUR
AU  - Besu, Irina
AU  - Srdić-Rajić, Tatjana
AU  - Matić, Ivana Z.
AU  - Janković, Ljiljana
AU  - Besu, Valeri
AU  - Konić-Ristić, Aleksandra
AU  - Juranič, Zorica
PY  - 2017
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1245
AB  - Despite the numerous benefits of milk constituents for human health a considerable number of the general population follow a milk-restricted diet due to clinically confirmed or self-assessed adverse reactions to cow’s milk consumption. Recurrent aphthous ulcers (RAU) are currently one of the most common oral disorders, with a worldwide distribution and insufficiently defined etiology, which, among other factors, implies the immunological reaction to food proteins. The aim of this study was to determine the immune-reactivity to donkey’s milk proteins in patients with RAU and compare it to the reactivity towards the proteins from cow’s and goat’s milks, in a set of simultaneous experiments. Levels of serum IgA, IgG and IgE antibodies to the same quantity of the examined antigens were determined by enzyme-linked immunosorbent assay. The results indicate that patients with RAU with increased immunity to cow’s milk proteins could consider the use of donkey’s milk as the best protein source.
PB  - Taylor & Francis
T2  - Food and Agricultural Immunology
T1  - The absence of immunoreactivity to donkey’s milk in patients with recurrent aphthous ulcers and immunoreactivity to cow’s milk
EP  - 462
IS  - 3
SP  - 452
VL  - 28
DO  - 10.1080/09540105.2017.1293017
ER  - 

@article{
author = "Besu, Irina and Srdić-Rajić, Tatjana and Matić, Ivana Z. and Janković, Ljiljana and Besu, Valeri and Konić-Ristić, Aleksandra and Juranič, Zorica",
year = "2017",
abstract = "Despite the numerous benefits of milk constituents for human health a considerable number of the general population follow a milk-restricted diet due to clinically confirmed or self-assessed adverse reactions to cow’s milk consumption. Recurrent aphthous ulcers (RAU) are currently one of the most common oral disorders, with a worldwide distribution and insufficiently defined etiology, which, among other factors, implies the immunological reaction to food proteins. The aim of this study was to determine the immune-reactivity to donkey’s milk proteins in patients with RAU and compare it to the reactivity towards the proteins from cow’s and goat’s milks, in a set of simultaneous experiments. Levels of serum IgA, IgG and IgE antibodies to the same quantity of the examined antigens were determined by enzyme-linked immunosorbent assay. The results indicate that patients with RAU with increased immunity to cow’s milk proteins could consider the use of donkey’s milk as the best protein source.",
publisher = "Taylor & Francis",
journal = "Food and Agricultural Immunology",
title = "The absence of immunoreactivity to donkey’s milk in patients with recurrent aphthous ulcers and immunoreactivity to cow’s milk",
pages = "462-452",
number = "3",
volume = "28",
doi = "10.1080/09540105.2017.1293017"
}

Besu, I., Srdić-Rajić, T., Matić, I. Z., Janković, L., Besu, V., Konić-Ristić, A.,& Juranič, Z.. (2017). The absence of immunoreactivity to donkey’s milk in patients with recurrent aphthous ulcers and immunoreactivity to cow’s milk. in Food and Agricultural Immunology
Taylor & Francis., 28(3), 452-462.
https://doi.org/10.1080/09540105.2017.1293017

Besu I, Srdić-Rajić T, Matić IZ, Janković L, Besu V, Konić-Ristić A, Juranič Z. The absence of immunoreactivity to donkey’s milk in patients with recurrent aphthous ulcers and immunoreactivity to cow’s milk. in Food and Agricultural Immunology. 2017;28(3):452-462.
doi:10.1080/09540105.2017.1293017 .

Besu, Irina, Srdić-Rajić, Tatjana, Matić, Ivana Z., Janković, Ljiljana, Besu, Valeri, Konić-Ristić, Aleksandra, Juranič, Zorica, "The absence of immunoreactivity to donkey’s milk in patients with recurrent aphthous ulcers and immunoreactivity to cow’s milk" in Food and Agricultural Immunology, 28, no. 3 (2017):452-462,
https://doi.org/10.1080/09540105.2017.1293017 . .

TY  - CHAP
AU  - Ranić, Marija M.
AU  - Konić-Ristić, Aleksandra
AU  - Glibetić, Marija
AU  - Dimitrijević-Branković, Suzana
PY  - 2016
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/684
AB  - A huge amount of espresso spent coffee grounds (SCG) are obtained as a waste product during the preparation of coffee beverages (cialdes, K-cups and in metallic filters). Although considered a waste and an ecological threat, SCGs could be an excellent source of bioactive components (mainly polyphenols) with outstanding antioxidative activity and potential to be used as raw material in fortified food production. The antiplatelet action of dietary polyphenols represents an important part of their pleiotropic action, and underlying mechanisms of their shown beneficial effects on cardiovascular health. Accordingly, a reduction in platelet aggregation was accepted by EFSA as a beneficial effect of food and dietary constituents, in the context of maintaining cardiovascular health enabling claims related to foods or substances affecting disturbed platelet function. Thus, platelets are considered an emerging target for the prophylactic effects of food bioactives in cardiovascular disease (CVD), with promising scientific evidence of their efficacy. The overall objective of this study was to examine an optimal range of extraction conditions for the extraction of polyphenols from espresso SCGs by using response surface methodology and to investigate the in vitro effects of obtained polyphenol-rich extracts on platelet activation and their aggregation with monocytes and neutrophiles. The obtained results indicated that espresso SCG extracts induce dose dependent inhibition of platelet activation, shown by the decrease in expression of P-selectin (8.7%) and GPIIb/IIIa (5.6%) and their aggregation with monocytes and neutrophiles (up to 20%). The sustainability of the coffee processing system can be substantially improved through the use of by-products by the adoption of new technologies that maximize process profitability. Shown antiplatelet effects of polyphenols, present in espresso coffee SCGs, indicate a favorable profile of bioactive compounds toward platelet function and thereby rationalize their use as functional food ingredients and nutraceuticals aiming to promote cardiovascular health.
T2  - Coffee: Production, Consumption & Health Benefits
T1  - The re-use potential of espresso spent coffee grounds: Optimization of microwave-assisted extraction of polyphenols by use of response surface methodology and their effects on platelet function - pilot study
EP  - 113
SP  - 97
UR  - https://hdl.handle.net/21.15107/rcub_technorep_3167
ER  - 

@inbook{
author = "Ranić, Marija M. and Konić-Ristić, Aleksandra and Glibetić, Marija and Dimitrijević-Branković, Suzana",
year = "2016",
abstract = "A huge amount of espresso spent coffee grounds (SCG) are obtained as a waste product during the preparation of coffee beverages (cialdes, K-cups and in metallic filters). Although considered a waste and an ecological threat, SCGs could be an excellent source of bioactive components (mainly polyphenols) with outstanding antioxidative activity and potential to be used as raw material in fortified food production. The antiplatelet action of dietary polyphenols represents an important part of their pleiotropic action, and underlying mechanisms of their shown beneficial effects on cardiovascular health. Accordingly, a reduction in platelet aggregation was accepted by EFSA as a beneficial effect of food and dietary constituents, in the context of maintaining cardiovascular health enabling claims related to foods or substances affecting disturbed platelet function. Thus, platelets are considered an emerging target for the prophylactic effects of food bioactives in cardiovascular disease (CVD), with promising scientific evidence of their efficacy. The overall objective of this study was to examine an optimal range of extraction conditions for the extraction of polyphenols from espresso SCGs by using response surface methodology and to investigate the in vitro effects of obtained polyphenol-rich extracts on platelet activation and their aggregation with monocytes and neutrophiles. The obtained results indicated that espresso SCG extracts induce dose dependent inhibition of platelet activation, shown by the decrease in expression of P-selectin (8.7%) and GPIIb/IIIa (5.6%) and their aggregation with monocytes and neutrophiles (up to 20%). The sustainability of the coffee processing system can be substantially improved through the use of by-products by the adoption of new technologies that maximize process profitability. Shown antiplatelet effects of polyphenols, present in espresso coffee SCGs, indicate a favorable profile of bioactive compounds toward platelet function and thereby rationalize their use as functional food ingredients and nutraceuticals aiming to promote cardiovascular health.",
journal = "Coffee: Production, Consumption & Health Benefits",
booktitle = "The re-use potential of espresso spent coffee grounds: Optimization of microwave-assisted extraction of polyphenols by use of response surface methodology and their effects on platelet function - pilot study",
pages = "113-97",
url = "https://hdl.handle.net/21.15107/rcub_technorep_3167"
}

Ranić, M. M., Konić-Ristić, A., Glibetić, M.,& Dimitrijević-Branković, S.. (2016). The re-use potential of espresso spent coffee grounds: Optimization of microwave-assisted extraction of polyphenols by use of response surface methodology and their effects on platelet function - pilot study. in Coffee: Production, Consumption & Health Benefits, 97-113.
https://hdl.handle.net/21.15107/rcub_technorep_3167

Ranić MM, Konić-Ristić A, Glibetić M, Dimitrijević-Branković S. The re-use potential of espresso spent coffee grounds: Optimization of microwave-assisted extraction of polyphenols by use of response surface methodology and their effects on platelet function - pilot study. in Coffee: Production, Consumption & Health Benefits. 2016;:97-113.
https://hdl.handle.net/21.15107/rcub_technorep_3167 .

Ranić, Marija M., Konić-Ristić, Aleksandra, Glibetić, Marija, Dimitrijević-Branković, Suzana, "The re-use potential of espresso spent coffee grounds: Optimization of microwave-assisted extraction of polyphenols by use of response surface methodology and their effects on platelet function - pilot study" in Coffee: Production, Consumption & Health Benefits (2016):97-113,
https://hdl.handle.net/21.15107/rcub_technorep_3167 .

TY  - JOUR
AU  - Krga, Irena
AU  - Monfoulet, Laurent-Emanuel
AU  - Konić-Ristić, Aleksandra
AU  - Mercier, Sylvie
AU  - Glibetić, Marija
AU  - Morand, Christine
AU  - Milenković, Dragan
PY  - 2016
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/718
AB  - An increasing number of evidence suggests a protective role of dietary anthocyanins against cardiovascular diseases. Anthocyanins' extensive metabolism indicates that their metabolites could be responsible for the protective effects associated with consumption of anthocyanin-rich foods. The aim of this work was to investigate the effect of plasma anthocyanins and their metabolites on the adhesion of monocytes to TNF alpha-activated endothelial cells and on the expression of genes encoding cell adhesion molecules. Human umbilical vein endothelial cells (HUVECs) were exposed to circulating anthocyanins: cyanidin-3-arabinoside, cyanidin-3-galactoside, cyanidin-3-glucoside, delphinidin-3-glucoside, peonidin-3-glucoside, anthocyanin degradation product: 4-hydroxybenzaidehyde, or to their gut metabolites: protocatechuic, vanillic, ferulic and hippuric acid, at physiologically-relevant concentrations (0.1-2 mu M) and time of exposure. Both anthocyanins and gut metabolites decreased the adhesion of monocytes to HUVECs, with a magnitude ranging from 18.1% to 47%. The mixture of anthocyanins and that of gut metabolites also reduced monocyte adhesion. However, no significant effect on the expression of genes encoding E-selectin, ICAM1 and VCAM1 was observed, suggesting that other molecular targets are involved in the observed effect. In conclusion, this study showed the potency of anthocyanins and their gut metabolites to modulate the adhesion of monocytes to endothelial cells, the initial step in atherosclerosis development, under physiologically-relevant conditions.
PB  - Elsevier Science Inc, New York
T2  - Archives of Biochemistry & Biophysics
T1  - Anthocyanins and their gut metabolites reduce the adhesion of monocyte to TNF alpha-activated endothelial cells at physiologically relevant concentrations
EP  - 59
SP  - 51
VL  - 599
DO  - 10.1016/j.abb.2016.02.006
ER  - 

@article{
author = "Krga, Irena and Monfoulet, Laurent-Emanuel and Konić-Ristić, Aleksandra and Mercier, Sylvie and Glibetić, Marija and Morand, Christine and Milenković, Dragan",
year = "2016",
abstract = "An increasing number of evidence suggests a protective role of dietary anthocyanins against cardiovascular diseases. Anthocyanins' extensive metabolism indicates that their metabolites could be responsible for the protective effects associated with consumption of anthocyanin-rich foods. The aim of this work was to investigate the effect of plasma anthocyanins and their metabolites on the adhesion of monocytes to TNF alpha-activated endothelial cells and on the expression of genes encoding cell adhesion molecules. Human umbilical vein endothelial cells (HUVECs) were exposed to circulating anthocyanins: cyanidin-3-arabinoside, cyanidin-3-galactoside, cyanidin-3-glucoside, delphinidin-3-glucoside, peonidin-3-glucoside, anthocyanin degradation product: 4-hydroxybenzaidehyde, or to their gut metabolites: protocatechuic, vanillic, ferulic and hippuric acid, at physiologically-relevant concentrations (0.1-2 mu M) and time of exposure. Both anthocyanins and gut metabolites decreased the adhesion of monocytes to HUVECs, with a magnitude ranging from 18.1% to 47%. The mixture of anthocyanins and that of gut metabolites also reduced monocyte adhesion. However, no significant effect on the expression of genes encoding E-selectin, ICAM1 and VCAM1 was observed, suggesting that other molecular targets are involved in the observed effect. In conclusion, this study showed the potency of anthocyanins and their gut metabolites to modulate the adhesion of monocytes to endothelial cells, the initial step in atherosclerosis development, under physiologically-relevant conditions.",
publisher = "Elsevier Science Inc, New York",
journal = "Archives of Biochemistry & Biophysics",
title = "Anthocyanins and their gut metabolites reduce the adhesion of monocyte to TNF alpha-activated endothelial cells at physiologically relevant concentrations",
pages = "59-51",
volume = "599",
doi = "10.1016/j.abb.2016.02.006"
}

Krga, I., Monfoulet, L., Konić-Ristić, A., Mercier, S., Glibetić, M., Morand, C.,& Milenković, D.. (2016). Anthocyanins and their gut metabolites reduce the adhesion of monocyte to TNF alpha-activated endothelial cells at physiologically relevant concentrations. in Archives of Biochemistry & Biophysics
Elsevier Science Inc, New York., 599, 51-59.
https://doi.org/10.1016/j.abb.2016.02.006

Krga I, Monfoulet L, Konić-Ristić A, Mercier S, Glibetić M, Morand C, Milenković D. Anthocyanins and their gut metabolites reduce the adhesion of monocyte to TNF alpha-activated endothelial cells at physiologically relevant concentrations. in Archives of Biochemistry & Biophysics. 2016;599:51-59.
doi:10.1016/j.abb.2016.02.006 .

Krga, Irena, Monfoulet, Laurent-Emanuel, Konić-Ristić, Aleksandra, Mercier, Sylvie, Glibetić, Marija, Morand, Christine, Milenković, Dragan, "Anthocyanins and their gut metabolites reduce the adhesion of monocyte to TNF alpha-activated endothelial cells at physiologically relevant concentrations" in Archives of Biochemistry & Biophysics, 599 (2016):51-59,
https://doi.org/10.1016/j.abb.2016.02.006 . .

TY  - JOUR
AU  - Ranić, Marija M.
AU  - Konić-Ristić, Aleksandra
AU  - Takić, Marija
AU  - Glibetić, Marija
AU  - Pavlović, Zoran
AU  - Pavlović, M.
AU  - Dimitrijević-Branković, Suzana
PY  - 2015
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/674
AB  - Accurate food composition data is essential in calculating the nutrient intake of a population based upon its consumption statistics. In the Serbian Food Composition Database (FCDB) there is a lack of reliable analytical data for black coffee, even though this is one of the most abundantly consumed beverages. In addition to evaluating the nutritional significance of black coffee consumption in Serbia, this work provides analytical data for inclusion in the Serbian FCDB, and the interchange through EuroFIR FoodEXplorer. Macronutrient, caffeine, chlorogenic acids (CGA), fatty acids and mineral content were analysed in a composite sample of roasted ground coffee, as well as in weak and strong infusions prepared in a traditional way. The macronutrient content of black coffee is in accordance with data from other FCDBs, confirming it to be of low-energy value and a modest contribution to the dietary intake of macronutrients. At the same time, consuming 200 mL (2 cups) of a strong infusion per day could provide more than 7.5% of the daily reference intake of potassium. The obtained results for caffeine and CGA in the investigated coffee infusions highlight the generally high daily consumption of these biologically active non-nutrient compounds among the Serbian population.
PB  - Academic Press Inc Elsevier Science, San Diego
T2  - Journal of Food Composition & Analysis
T1  - Nutrient profile of black coffee consumed in Serbia: Filling a gap in the food composition database
EP  - 69
SP  - 61
VL  - 40
DO  - 10.1016/j.jfca.2014.11.008
ER  - 

@article{
author = "Ranić, Marija M. and Konić-Ristić, Aleksandra and Takić, Marija and Glibetić, Marija and Pavlović, Zoran and Pavlović, M. and Dimitrijević-Branković, Suzana",
year = "2015",
abstract = "Accurate food composition data is essential in calculating the nutrient intake of a population based upon its consumption statistics. In the Serbian Food Composition Database (FCDB) there is a lack of reliable analytical data for black coffee, even though this is one of the most abundantly consumed beverages. In addition to evaluating the nutritional significance of black coffee consumption in Serbia, this work provides analytical data for inclusion in the Serbian FCDB, and the interchange through EuroFIR FoodEXplorer. Macronutrient, caffeine, chlorogenic acids (CGA), fatty acids and mineral content were analysed in a composite sample of roasted ground coffee, as well as in weak and strong infusions prepared in a traditional way. The macronutrient content of black coffee is in accordance with data from other FCDBs, confirming it to be of low-energy value and a modest contribution to the dietary intake of macronutrients. At the same time, consuming 200 mL (2 cups) of a strong infusion per day could provide more than 7.5% of the daily reference intake of potassium. The obtained results for caffeine and CGA in the investigated coffee infusions highlight the generally high daily consumption of these biologically active non-nutrient compounds among the Serbian population.",
publisher = "Academic Press Inc Elsevier Science, San Diego",
journal = "Journal of Food Composition & Analysis",
title = "Nutrient profile of black coffee consumed in Serbia: Filling a gap in the food composition database",
pages = "69-61",
volume = "40",
doi = "10.1016/j.jfca.2014.11.008"
}

Ranić, M. M., Konić-Ristić, A., Takić, M., Glibetić, M., Pavlović, Z., Pavlović, M.,& Dimitrijević-Branković, S.. (2015). Nutrient profile of black coffee consumed in Serbia: Filling a gap in the food composition database. in Journal of Food Composition & Analysis
Academic Press Inc Elsevier Science, San Diego., 40, 61-69.
https://doi.org/10.1016/j.jfca.2014.11.008

Ranić MM, Konić-Ristić A, Takić M, Glibetić M, Pavlović Z, Pavlović M, Dimitrijević-Branković S. Nutrient profile of black coffee consumed in Serbia: Filling a gap in the food composition database. in Journal of Food Composition & Analysis. 2015;40:61-69.
doi:10.1016/j.jfca.2014.11.008 .

Ranić, Marija M., Konić-Ristić, Aleksandra, Takić, Marija, Glibetić, Marija, Pavlović, Zoran, Pavlović, M., Dimitrijević-Branković, Suzana, "Nutrient profile of black coffee consumed in Serbia: Filling a gap in the food composition database" in Journal of Food Composition & Analysis, 40 (2015):61-69,
https://doi.org/10.1016/j.jfca.2014.11.008 . .

TY  - CONF
AU  - Ranić, Marija M.
AU  - Milutinović, Milica
AU  - Konić-Ristić, Aleksandra
AU  - Dimitrijević-Branković, Suzana
PY  - 2015
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/635
PB  - Karger, Basel
C3  - Annals of Nutrition & Metabolism
T1  - Optimization of microwave-assisted extraction of natural antioxidants from spent black coffee grounds by response surface methodology
EP  - 547
SP  - 547
VL  - 67
UR  - https://hdl.handle.net/21.15107/rcub_technorep_3103
ER  - 

@conference{
author = "Ranić, Marija M. and Milutinović, Milica and Konić-Ristić, Aleksandra and Dimitrijević-Branković, Suzana",
year = "2015",
publisher = "Karger, Basel",
journal = "Annals of Nutrition & Metabolism",
title = "Optimization of microwave-assisted extraction of natural antioxidants from spent black coffee grounds by response surface methodology",
pages = "547-547",
volume = "67",
url = "https://hdl.handle.net/21.15107/rcub_technorep_3103"
}

Ranić, M. M., Milutinović, M., Konić-Ristić, A.,& Dimitrijević-Branković, S.. (2015). Optimization of microwave-assisted extraction of natural antioxidants from spent black coffee grounds by response surface methodology. in Annals of Nutrition & Metabolism
Karger, Basel., 67, 547-547.
https://hdl.handle.net/21.15107/rcub_technorep_3103

Ranić MM, Milutinović M, Konić-Ristić A, Dimitrijević-Branković S. Optimization of microwave-assisted extraction of natural antioxidants from spent black coffee grounds by response surface methodology. in Annals of Nutrition & Metabolism. 2015;67:547-547.
https://hdl.handle.net/21.15107/rcub_technorep_3103 .

Ranić, Marija M., Milutinović, Milica, Konić-Ristić, Aleksandra, Dimitrijević-Branković, Suzana, "Optimization of microwave-assisted extraction of natural antioxidants from spent black coffee grounds by response surface methodology" in Annals of Nutrition & Metabolism, 67 (2015):547-547,
https://hdl.handle.net/21.15107/rcub_technorep_3103 .

TY  - JOUR
AU  - Konić-Ristić, Aleksandra
AU  - Kroon, Paul A.
AU  - Glibetić, Marija
PY  - 2015
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/614
AB  - Beyond being central players in haemostasis and thrombosis, platelets have crucial roles in the development of atherosclerosis, mediated through their interactions with monocytes and endothelial cells. Disturbed platelet function correlates with other risk factors and the progression of CVD, postulating platelets as rational targets in CVD prevention. The effects of polyphenols on platelets have been studied in numerous pre-clinical and clinical trials, and the data reported from these studies support the hypothesis that modulation of platelet function contributes significantly to pleiotropic beneficial effects of polyphenols on cardiovascular health. To provide comprehensive scientific evidence for the promotion of polyphenols as antiplatelet agents, further studies should address the influence of polyphenol metabolism on the observed effects, identify active polyphenols/metabolites and elucidate the precise mechanisms of their action.
PB  - Teknoscienze Publ, Milano
T2  - Agro Food Industry Hi-Tech
T1  - Modulation of platelet function with dietary polyphenols A promising strategy in the prevention of cardiovascular disease
EP  - 18
IS  - 2
SP  - 15
VL  - 26
UR  - https://hdl.handle.net/21.15107/rcub_rimi_614
ER  - 

@article{
author = "Konić-Ristić, Aleksandra and Kroon, Paul A. and Glibetić, Marija",
year = "2015",
abstract = "Beyond being central players in haemostasis and thrombosis, platelets have crucial roles in the development of atherosclerosis, mediated through their interactions with monocytes and endothelial cells. Disturbed platelet function correlates with other risk factors and the progression of CVD, postulating platelets as rational targets in CVD prevention. The effects of polyphenols on platelets have been studied in numerous pre-clinical and clinical trials, and the data reported from these studies support the hypothesis that modulation of platelet function contributes significantly to pleiotropic beneficial effects of polyphenols on cardiovascular health. To provide comprehensive scientific evidence for the promotion of polyphenols as antiplatelet agents, further studies should address the influence of polyphenol metabolism on the observed effects, identify active polyphenols/metabolites and elucidate the precise mechanisms of their action.",
publisher = "Teknoscienze Publ, Milano",
journal = "Agro Food Industry Hi-Tech",
title = "Modulation of platelet function with dietary polyphenols A promising strategy in the prevention of cardiovascular disease",
pages = "18-15",
number = "2",
volume = "26",
url = "https://hdl.handle.net/21.15107/rcub_rimi_614"
}

Konić-Ristić, A., Kroon, P. A.,& Glibetić, M.. (2015). Modulation of platelet function with dietary polyphenols A promising strategy in the prevention of cardiovascular disease. in Agro Food Industry Hi-Tech
Teknoscienze Publ, Milano., 26(2), 15-18.
https://hdl.handle.net/21.15107/rcub_rimi_614

Konić-Ristić A, Kroon PA, Glibetić M. Modulation of platelet function with dietary polyphenols A promising strategy in the prevention of cardiovascular disease. in Agro Food Industry Hi-Tech. 2015;26(2):15-18.
https://hdl.handle.net/21.15107/rcub_rimi_614 .

Konić-Ristić, Aleksandra, Kroon, Paul A., Glibetić, Marija, "Modulation of platelet function with dietary polyphenols A promising strategy in the prevention of cardiovascular disease" in Agro Food Industry Hi-Tech, 26, no. 2 (2015):15-18,
https://hdl.handle.net/21.15107/rcub_rimi_614 .

TY  - JOUR
AU  - Srdić-Rajić, Tatjana
AU  - Konić-Ristić, Aleksandra
AU  - Tišma-Miletić, Nevena
AU  - Kardum, Nevena Đ.
AU  - Galun, Daniel
AU  - Sikimić, Jelena
AU  - Glibetić, Marija
AU  - Milićević, Miroslav
PY  - 2015
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/618
AB  - BACKGROUND: Viscum album preparations are extensively used as complementary therapy in cancer and are shown to exert antitumor activities which involve the cytotoxic properties, induction of apoptosis, inhibition of angiogenesis and several other immunomodulatory mechanisms. AIM: The aim of this study was to investigate the eft fects of mistletoe extract on platelet as well as monocyte functions, as an important factors in immunomodulation of cancers metas tatic potencial and angiogenesis in tumors. METHODS: The effect of different concentrations of mistletoe extract on agonist-induced platelet activation markers and their aggregation with leukocytes was examined in the blood of healthy subjects ( n = 6 ) using flow cytometry. Effects on LPS -induced activation markers was det ermined in the blood of healthy subj ects as well as on THP- 1 cell line using an ELISA essays and flow cytometry. RESULTS: Mistletoe extract significantly inhibited agonist induced P selectin expression and platelet-monocytes aggregation. Additionally, mistletoe extract exerts anti-tumor effect through the stimulation of TNF-a production in LPS induced monocytes activation. CONCLUSION: Obtained data demonstrate that mistletoe extract was effective in modulating platelet and monocyte functions, as a part of pleiotropic anticancer effect.
AB  - UVOD: Preparati biljke Viscum album se intenzivno koriste kao komplementarna terapija u lecenju kancera. Mehanizmi antitumorskog delovanja, potvrđeni in vitro, ukljucuju citotoksicno delovanje, indukciju apoptoze, inhibiciju angiogeneze, imunomodulatorno delovanje. CILJ: Cilj ovog istraživanja je ispitivanje uticaja ekstrakta bele imele na funkciju trombocita i monocita kao važnih faktora u imunomodulaciji kancerskog procesa, metastatskom potencijalu i tumorskoj angiogenezi. METODE: Uticaj razlicitih koncentracija ekstrakta bele imele na markere agonistom indukovane aktivacije trombocita i njihove agregacije sa leukocitima ispitivan je u krvi zdravih ispitanika (n=6) primenom protocne citometrije. Uticaj na markere LPS indukovane aktivacije određivan je u krvi ispitanika i kulturi THP-1 celija korišceenjem ELISA eseja i protocne citometrije. REZULTATI: Ekstrakt imele znacajno inhibira ekspresiju P-selektina i trombocitno-monocitnu agregaciju. Pokazana stimulacija produkcije TNF-a u LPS-om aktiviranim monocitima dodatno doprinosi antitumorskom potencijalu. ZAKLJUČAK: Dobijeni rezultati potvrđuju potenci jal ekstrakta imele da modulira trombocitnu i monocitnu funkciju, kao deo pleotropnog antitumorskog delovanja.
PB  - Udruženje hirurga Jugoslavije, Beograd
T2  - Acta chirurgica iugoslavica
T1  - Effects of mistletoe extract on markers of platelet activation and aggregation
T1  - Efekti ekstrakta bele imele na markere aktivacije i agregacije trombocita
EP  - 13
IS  - 2
SP  - 5
VL  - 62
DO  - 10.2298/aci1502005S
ER  - 

@article{
author = "Srdić-Rajić, Tatjana and Konić-Ristić, Aleksandra and Tišma-Miletić, Nevena and Kardum, Nevena Đ. and Galun, Daniel and Sikimić, Jelena and Glibetić, Marija and Milićević, Miroslav",
year = "2015",
abstract = "BACKGROUND: Viscum album preparations are extensively used as complementary therapy in cancer and are shown to exert antitumor activities which involve the cytotoxic properties, induction of apoptosis, inhibition of angiogenesis and several other immunomodulatory mechanisms. AIM: The aim of this study was to investigate the eft fects of mistletoe extract on platelet as well as monocyte functions, as an important factors in immunomodulation of cancers metas tatic potencial and angiogenesis in tumors. METHODS: The effect of different concentrations of mistletoe extract on agonist-induced platelet activation markers and their aggregation with leukocytes was examined in the blood of healthy subjects ( n = 6 ) using flow cytometry. Effects on LPS -induced activation markers was det ermined in the blood of healthy subj ects as well as on THP- 1 cell line using an ELISA essays and flow cytometry. RESULTS: Mistletoe extract significantly inhibited agonist induced P selectin expression and platelet-monocytes aggregation. Additionally, mistletoe extract exerts anti-tumor effect through the stimulation of TNF-a production in LPS induced monocytes activation. CONCLUSION: Obtained data demonstrate that mistletoe extract was effective in modulating platelet and monocyte functions, as a part of pleiotropic anticancer effect., UVOD: Preparati biljke Viscum album se intenzivno koriste kao komplementarna terapija u lecenju kancera. Mehanizmi antitumorskog delovanja, potvrđeni in vitro, ukljucuju citotoksicno delovanje, indukciju apoptoze, inhibiciju angiogeneze, imunomodulatorno delovanje. CILJ: Cilj ovog istraživanja je ispitivanje uticaja ekstrakta bele imele na funkciju trombocita i monocita kao važnih faktora u imunomodulaciji kancerskog procesa, metastatskom potencijalu i tumorskoj angiogenezi. METODE: Uticaj razlicitih koncentracija ekstrakta bele imele na markere agonistom indukovane aktivacije trombocita i njihove agregacije sa leukocitima ispitivan je u krvi zdravih ispitanika (n=6) primenom protocne citometrije. Uticaj na markere LPS indukovane aktivacije određivan je u krvi ispitanika i kulturi THP-1 celija korišceenjem ELISA eseja i protocne citometrije. REZULTATI: Ekstrakt imele znacajno inhibira ekspresiju P-selektina i trombocitno-monocitnu agregaciju. Pokazana stimulacija produkcije TNF-a u LPS-om aktiviranim monocitima dodatno doprinosi antitumorskom potencijalu. ZAKLJUČAK: Dobijeni rezultati potvrđuju potenci jal ekstrakta imele da modulira trombocitnu i monocitnu funkciju, kao deo pleotropnog antitumorskog delovanja.",
publisher = "Udruženje hirurga Jugoslavije, Beograd",
journal = "Acta chirurgica iugoslavica",
title = "Effects of mistletoe extract on markers of platelet activation and aggregation, Efekti ekstrakta bele imele na markere aktivacije i agregacije trombocita",
pages = "13-5",
number = "2",
volume = "62",
doi = "10.2298/aci1502005S"
}

Srdić-Rajić, T., Konić-Ristić, A., Tišma-Miletić, N., Kardum, N. Đ., Galun, D., Sikimić, J., Glibetić, M.,& Milićević, M.. (2015). Effects of mistletoe extract on markers of platelet activation and aggregation. in Acta chirurgica iugoslavica
Udruženje hirurga Jugoslavije, Beograd., 62(2), 5-13.
https://doi.org/10.2298/aci1502005S

Srdić-Rajić T, Konić-Ristić A, Tišma-Miletić N, Kardum NĐ, Galun D, Sikimić J, Glibetić M, Milićević M. Effects of mistletoe extract on markers of platelet activation and aggregation. in Acta chirurgica iugoslavica. 2015;62(2):5-13.
doi:10.2298/aci1502005S .

Srdić-Rajić, Tatjana, Konić-Ristić, Aleksandra, Tišma-Miletić, Nevena, Kardum, Nevena Đ., Galun, Daniel, Sikimić, Jelena, Glibetić, Marija, Milićević, Miroslav, "Effects of mistletoe extract on markers of platelet activation and aggregation" in Acta chirurgica iugoslavica, 62, no. 2 (2015):5-13,
https://doi.org/10.2298/aci1502005S . .

TY  - JOUR
AU  - Konić-Ristić, Aleksandra
AU  - Savikin, Katarina
AU  - Zdunić, Gordana
AU  - Besu, Irina
AU  - Menković, Nebojša
AU  - Glibetić, Marija
AU  - Srdić-Rajić, Tatjana
PY  - 2015
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/660
AB  - The role of saliva in maintaining oral health and homeostasis is based on its physicochemical properties and biological activities of its components, including salivary immunoglobulin A (IgA). Both salivary rates and immunological status of saliva are found to be compromised in smokers. The aim of this study was to investigate the acute time-dependent effect of smoking and black currant consumption on the salivary flow rate (SFR) and salivary IgA secretion rate (sIgA SR) in healthy smokers. SFR, sIgA levels in saliva, and sIgA SRs were determined in healthy smokers (n=8) at eight times of assessment within three consecutive interventions: at the baseline; 5, 30, and 60 min after smoking; 5, 30, and 60 min after black currant consumption (100 g), followed by smoking; and 5 min after black currant consumption. Smoking induced a significant delayed effect on SFR measured 60 min after smoking (P=.03), while black currant consumption preceding smoking prevented that effect. Salivary IgA concentrations and sIgA flow rates were not acutely influenced by smoking. Black currant consumption preceding smoking induced a significant decrease in sIgA concentrations 5 min after the intervention compared with the baseline (P=.046), with a further increasing trend, statistically significant, 60 min after the intervention (P=.025). Although smoking cessation is the most important strategy in the prevention of chronic diseases, the obtained results suggest that the influence of black currant consumption on negative effects of tobacco smoke on salivary flow and immunological status of saliva could partly reduce the smoking-associated risk on oral health.
PB  - Mary Ann Liebert, Inc, New Rochelle
T2  - Journal of Medicinal Food
T1  - Acute Effects of Black Currant Consumption on Salivary Flow Rate and Secretion Rate of Salivary Immunoglobulin A in Healthy Smokers
EP  - 488
IS  - 4
SP  - 483
VL  - 18
DO  - 10.1089/jmf.2013.0149
ER  - 

@article{
author = "Konić-Ristić, Aleksandra and Savikin, Katarina and Zdunić, Gordana and Besu, Irina and Menković, Nebojša and Glibetić, Marija and Srdić-Rajić, Tatjana",
year = "2015",
abstract = "The role of saliva in maintaining oral health and homeostasis is based on its physicochemical properties and biological activities of its components, including salivary immunoglobulin A (IgA). Both salivary rates and immunological status of saliva are found to be compromised in smokers. The aim of this study was to investigate the acute time-dependent effect of smoking and black currant consumption on the salivary flow rate (SFR) and salivary IgA secretion rate (sIgA SR) in healthy smokers. SFR, sIgA levels in saliva, and sIgA SRs were determined in healthy smokers (n=8) at eight times of assessment within three consecutive interventions: at the baseline; 5, 30, and 60 min after smoking; 5, 30, and 60 min after black currant consumption (100 g), followed by smoking; and 5 min after black currant consumption. Smoking induced a significant delayed effect on SFR measured 60 min after smoking (P=.03), while black currant consumption preceding smoking prevented that effect. Salivary IgA concentrations and sIgA flow rates were not acutely influenced by smoking. Black currant consumption preceding smoking induced a significant decrease in sIgA concentrations 5 min after the intervention compared with the baseline (P=.046), with a further increasing trend, statistically significant, 60 min after the intervention (P=.025). Although smoking cessation is the most important strategy in the prevention of chronic diseases, the obtained results suggest that the influence of black currant consumption on negative effects of tobacco smoke on salivary flow and immunological status of saliva could partly reduce the smoking-associated risk on oral health.",
publisher = "Mary Ann Liebert, Inc, New Rochelle",
journal = "Journal of Medicinal Food",
title = "Acute Effects of Black Currant Consumption on Salivary Flow Rate and Secretion Rate of Salivary Immunoglobulin A in Healthy Smokers",
pages = "488-483",
number = "4",
volume = "18",
doi = "10.1089/jmf.2013.0149"
}

Konić-Ristić, A., Savikin, K., Zdunić, G., Besu, I., Menković, N., Glibetić, M.,& Srdić-Rajić, T.. (2015). Acute Effects of Black Currant Consumption on Salivary Flow Rate and Secretion Rate of Salivary Immunoglobulin A in Healthy Smokers. in Journal of Medicinal Food
Mary Ann Liebert, Inc, New Rochelle., 18(4), 483-488.
https://doi.org/10.1089/jmf.2013.0149

Konić-Ristić A, Savikin K, Zdunić G, Besu I, Menković N, Glibetić M, Srdić-Rajić T. Acute Effects of Black Currant Consumption on Salivary Flow Rate and Secretion Rate of Salivary Immunoglobulin A in Healthy Smokers. in Journal of Medicinal Food. 2015;18(4):483-488.
doi:10.1089/jmf.2013.0149 .

Konić-Ristić, Aleksandra, Savikin, Katarina, Zdunić, Gordana, Besu, Irina, Menković, Nebojša, Glibetić, Marija, Srdić-Rajić, Tatjana, "Acute Effects of Black Currant Consumption on Salivary Flow Rate and Secretion Rate of Salivary Immunoglobulin A in Healthy Smokers" in Journal of Medicinal Food, 18, no. 4 (2015):483-488,
https://doi.org/10.1089/jmf.2013.0149 . .

TY  - JOUR
AU  - Kardum, Nevena Đ.
AU  - Takić, Marija.
AU  - Savikin, Katarina
AU  - Zec, Manja M.
AU  - Zdunić, Gordana
AU  - Spasić, Slavica
AU  - Konić-Ristić, Aleksandra
PY  - 2014
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/583
AB  - The effect of long-term polyphenol-rich chokeberry juice consumption on activities of antioxidant enzymes and membrane lipid status in erythrocytes of 25 healthy women was examined. Percentages of membrane fatty acids, superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities were assessed at a baseline, in the middle and at the end of a 3-month-long consumption period. A significant increase in C22:6n-3, n-3 polyunsaturated fatty acids (PUFAs), total PUFAs and unsaturation index and a significant decrease in monounsaturated fatty acids (MUFAs) and n-6:n-3 ratio were found. Significantly higher SOD and GP(x) activities were also recorded at the end of the study. Serum lipids and glucose were stabile during the consumption period, while the levels of thiobarbituric acid-reactive substances (TBARS), as serum indicator of lipid peroxidation, were reduced significantly. These results indicate a positive impact of regular chokeberry juice consumption on cellular oxidative damage and suggest its putative role in the protection against oxidative stress.
PB  - Elsevier, Amsterdam
T2  - Journal of Functional Foods
T1  - Effects of polyphenol-rich chokeberry juice on cellular antioxidant enzymes and membrane lipid status in healthy women
EP  - 97
SP  - 89
VL  - 9
DO  - 10.1016/j.jff.2014.04.019
ER  - 

@article{
author = "Kardum, Nevena Đ. and Takić, Marija. and Savikin, Katarina and Zec, Manja M. and Zdunić, Gordana and Spasić, Slavica and Konić-Ristić, Aleksandra",
year = "2014",
abstract = "The effect of long-term polyphenol-rich chokeberry juice consumption on activities of antioxidant enzymes and membrane lipid status in erythrocytes of 25 healthy women was examined. Percentages of membrane fatty acids, superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities were assessed at a baseline, in the middle and at the end of a 3-month-long consumption period. A significant increase in C22:6n-3, n-3 polyunsaturated fatty acids (PUFAs), total PUFAs and unsaturation index and a significant decrease in monounsaturated fatty acids (MUFAs) and n-6:n-3 ratio were found. Significantly higher SOD and GP(x) activities were also recorded at the end of the study. Serum lipids and glucose were stabile during the consumption period, while the levels of thiobarbituric acid-reactive substances (TBARS), as serum indicator of lipid peroxidation, were reduced significantly. These results indicate a positive impact of regular chokeberry juice consumption on cellular oxidative damage and suggest its putative role in the protection against oxidative stress.",
publisher = "Elsevier, Amsterdam",
journal = "Journal of Functional Foods",
title = "Effects of polyphenol-rich chokeberry juice on cellular antioxidant enzymes and membrane lipid status in healthy women",
pages = "97-89",
volume = "9",
doi = "10.1016/j.jff.2014.04.019"
}

Kardum, N. Đ., Takić, Marija., Savikin, K., Zec, M. M., Zdunić, G., Spasić, S.,& Konić-Ristić, A.. (2014). Effects of polyphenol-rich chokeberry juice on cellular antioxidant enzymes and membrane lipid status in healthy women. in Journal of Functional Foods
Elsevier, Amsterdam., 9, 89-97.
https://doi.org/10.1016/j.jff.2014.04.019

Kardum NĐ, Takić M, Savikin K, Zec MM, Zdunić G, Spasić S, Konić-Ristić A. Effects of polyphenol-rich chokeberry juice on cellular antioxidant enzymes and membrane lipid status in healthy women. in Journal of Functional Foods. 2014;9:89-97.
doi:10.1016/j.jff.2014.04.019 .

Kardum, Nevena Đ., Takić, Marija., Savikin, Katarina, Zec, Manja M., Zdunić, Gordana, Spasić, Slavica, Konić-Ristić, Aleksandra, "Effects of polyphenol-rich chokeberry juice on cellular antioxidant enzymes and membrane lipid status in healthy women" in Journal of Functional Foods, 9 (2014):89-97,
https://doi.org/10.1016/j.jff.2014.04.019 . .

TY  - JOUR
AU  - Kardum, Nevena Đ.
AU  - Petrović-Oggiano, Gordana P.
AU  - Takić, Marija
AU  - Glibetić, Marija
AU  - Zec, Manja M.
AU  - Debeljak-Martačić, Jasmina
AU  - Konić-Ristić, Aleksandra
PY  - 2014
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/584
AB  - The aim of this study was to analyze the effects of a 4-week-long consumption of glucomannan-enriched, aronia juice-based supplement on anthropometric parameters, membrane fatty acid profile, and status of antioxidant enzymes in erythrocytes obtained from postmenopausal women with abdominal obesity. Twenty women aged 45-65 with a mean body mass index (BMI) of 36.1 ± 4.4 kg/m2 and waist circumference of 104.8 ± 10.1 cm were enrolled. Participants were instructed to consume 100 mL of supplement per day as part of their regular diet. A significant increase in the content of n-3 (P<0.05) polyunsaturated fatty acids in membrane phospholipids was observed, with a marked increase in the level of docosahexaenoic fatty acid (P<0.05). Accordingly, a decrease in the n-6 and n-3 fatty acids ratio was observed (P<0.05). The observed effects were accompanied with an increase in glutathione peroxidase activity (P<0.05). Values for BMI (P<0.001), waist circumference (P<0.001), and systolic blood pressure (P<0.05) were significantly lower after the intervention. The obtained results indicate a positive impact of tested supplement on cellular oxidative damage, blood pressure, and anthropometric indices of obesity. © 2014 Nevena Kardum et al.
PB  - Hindawi Limited
T2  - Scientific World Journal
T1  - Effects of glucomannan-enriched, aronia juice-based supplement on cellular antioxidant enzymes and membrane lipid status in subjects with abdominal obesity
VL  - 2014
DO  - 10.1155/2014/869250
ER  - 

@article{
author = "Kardum, Nevena Đ. and Petrović-Oggiano, Gordana P. and Takić, Marija and Glibetić, Marija and Zec, Manja M. and Debeljak-Martačić, Jasmina and Konić-Ristić, Aleksandra",
year = "2014",
abstract = "The aim of this study was to analyze the effects of a 4-week-long consumption of glucomannan-enriched, aronia juice-based supplement on anthropometric parameters, membrane fatty acid profile, and status of antioxidant enzymes in erythrocytes obtained from postmenopausal women with abdominal obesity. Twenty women aged 45-65 with a mean body mass index (BMI) of 36.1 ± 4.4 kg/m2 and waist circumference of 104.8 ± 10.1 cm were enrolled. Participants were instructed to consume 100 mL of supplement per day as part of their regular diet. A significant increase in the content of n-3 (P<0.05) polyunsaturated fatty acids in membrane phospholipids was observed, with a marked increase in the level of docosahexaenoic fatty acid (P<0.05). Accordingly, a decrease in the n-6 and n-3 fatty acids ratio was observed (P<0.05). The observed effects were accompanied with an increase in glutathione peroxidase activity (P<0.05). Values for BMI (P<0.001), waist circumference (P<0.001), and systolic blood pressure (P<0.05) were significantly lower after the intervention. The obtained results indicate a positive impact of tested supplement on cellular oxidative damage, blood pressure, and anthropometric indices of obesity. © 2014 Nevena Kardum et al.",
publisher = "Hindawi Limited",
journal = "Scientific World Journal",
title = "Effects of glucomannan-enriched, aronia juice-based supplement on cellular antioxidant enzymes and membrane lipid status in subjects with abdominal obesity",
volume = "2014",
doi = "10.1155/2014/869250"
}

Kardum, N. Đ., Petrović-Oggiano, G. P., Takić, M., Glibetić, M., Zec, M. M., Debeljak-Martačić, J.,& Konić-Ristić, A.. (2014). Effects of glucomannan-enriched, aronia juice-based supplement on cellular antioxidant enzymes and membrane lipid status in subjects with abdominal obesity. in Scientific World Journal
Hindawi Limited., 2014.
https://doi.org/10.1155/2014/869250

Kardum NĐ, Petrović-Oggiano GP, Takić M, Glibetić M, Zec MM, Debeljak-Martačić J, Konić-Ristić A. Effects of glucomannan-enriched, aronia juice-based supplement on cellular antioxidant enzymes and membrane lipid status in subjects with abdominal obesity. in Scientific World Journal. 2014;2014.
doi:10.1155/2014/869250 .

Kardum, Nevena Đ., Petrović-Oggiano, Gordana P., Takić, Marija, Glibetić, Marija, Zec, Manja M., Debeljak-Martačić, Jasmina, Konić-Ristić, Aleksandra, "Effects of glucomannan-enriched, aronia juice-based supplement on cellular antioxidant enzymes and membrane lipid status in subjects with abdominal obesity" in Scientific World Journal, 2014 (2014),
https://doi.org/10.1155/2014/869250 . .

TY  - JOUR
AU  - Savikin, Katarina
AU  - Menković, Nemanja
AU  - Zdunić, Gordana
AU  - Pljevljakusić, Dejan
AU  - Spasić, Slavica
AU  - Kardum, Nevena Đ.
AU  - Konić-Ristić, Aleksandra
PY  - 2014
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/587
AB  - The aim of our study was to investigate possible beneficial effects of organic chokeberry juice (OCJ) consumption in the treatment of cellulite. Twenty-nine women aged 25-48 with a cellulite grade 2 according to the Nurnberger-Muller scale were included. Anthropometric and biochemical parameters were measured. Skin structure was analyzed by ultrasonography. All subjects consumed 100mL of OCJ per day, during 90 days. Measurements of investigated parameters were performed at 0, 45, and 90 days of the study. A marked reduction in the subcutaneous tissue thickness was observed in all subjects, with the average reduction of 1.9mm. The length of subcutaneous tissue fascicles (ScTFL) was reduced in 97% (28 out of 29) of subjects, with the average value of 1.18mm. After 45 days of chokeberry juice consumption, reduction of edema was observed in 55.2% of the subjects with edema at the baseline, while at the endpoint of the study, edemas were not observed in any of the subjects involved in the study. OCJ could have beneficial effects on the cellulite condition, including the length of ScTFL, subcutaneous tissue, and dermis thickness as well as on edema reduction.
PB  - Mary Ann Liebert, Inc, New Rochelle
T2  - Journal of Medicinal Food
T1  - Dietary Supplementation with Polyphenol-Rich Chokeberry Juice Improves Skin Morphology in Cellulite
EP  - 587
IS  - 5
SP  - 582
VL  - 17
DO  - 10.1089/jmf.2013.0102
ER  - 

@article{
author = "Savikin, Katarina and Menković, Nemanja and Zdunić, Gordana and Pljevljakusić, Dejan and Spasić, Slavica and Kardum, Nevena Đ. and Konić-Ristić, Aleksandra",
year = "2014",
abstract = "The aim of our study was to investigate possible beneficial effects of organic chokeberry juice (OCJ) consumption in the treatment of cellulite. Twenty-nine women aged 25-48 with a cellulite grade 2 according to the Nurnberger-Muller scale were included. Anthropometric and biochemical parameters were measured. Skin structure was analyzed by ultrasonography. All subjects consumed 100mL of OCJ per day, during 90 days. Measurements of investigated parameters were performed at 0, 45, and 90 days of the study. A marked reduction in the subcutaneous tissue thickness was observed in all subjects, with the average reduction of 1.9mm. The length of subcutaneous tissue fascicles (ScTFL) was reduced in 97% (28 out of 29) of subjects, with the average value of 1.18mm. After 45 days of chokeberry juice consumption, reduction of edema was observed in 55.2% of the subjects with edema at the baseline, while at the endpoint of the study, edemas were not observed in any of the subjects involved in the study. OCJ could have beneficial effects on the cellulite condition, including the length of ScTFL, subcutaneous tissue, and dermis thickness as well as on edema reduction.",
publisher = "Mary Ann Liebert, Inc, New Rochelle",
journal = "Journal of Medicinal Food",
title = "Dietary Supplementation with Polyphenol-Rich Chokeberry Juice Improves Skin Morphology in Cellulite",
pages = "587-582",
number = "5",
volume = "17",
doi = "10.1089/jmf.2013.0102"
}

Savikin, K., Menković, N., Zdunić, G., Pljevljakusić, D., Spasić, S., Kardum, N. Đ.,& Konić-Ristić, A.. (2014). Dietary Supplementation with Polyphenol-Rich Chokeberry Juice Improves Skin Morphology in Cellulite. in Journal of Medicinal Food
Mary Ann Liebert, Inc, New Rochelle., 17(5), 582-587.
https://doi.org/10.1089/jmf.2013.0102

Savikin K, Menković N, Zdunić G, Pljevljakusić D, Spasić S, Kardum NĐ, Konić-Ristić A. Dietary Supplementation with Polyphenol-Rich Chokeberry Juice Improves Skin Morphology in Cellulite. in Journal of Medicinal Food. 2014;17(5):582-587.
doi:10.1089/jmf.2013.0102 .

Savikin, Katarina, Menković, Nemanja, Zdunić, Gordana, Pljevljakusić, Dejan, Spasić, Slavica, Kardum, Nevena Đ., Konić-Ristić, Aleksandra, "Dietary Supplementation with Polyphenol-Rich Chokeberry Juice Improves Skin Morphology in Cellulite" in Journal of Medicinal Food, 17, no. 5 (2014):582-587,
https://doi.org/10.1089/jmf.2013.0102 . .

TY  - JOUR
AU  - Kardum, Nevena Đ.
AU  - Konić-Ristić, Aleksandra
AU  - Savikin, Katarina
AU  - Spasić, Slavica
AU  - Stefanović, Aleksandra
AU  - Ivanišević, Jasmina
AU  - Miljković, Milica
PY  - 2014
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/568
AB  - Berry fruits are a rich source of polyphenols, especially anthocyanins: well-known potent anti-oxidant phytochemicals. The purpose of this study was to evaluate beneficial effects of long-term consumption of polyphenol-rich organic chokeberry juice on different markers of antioxidant/pro-oxidant status in healthy female volunteers. Twenty-nine women, aged 25-49, were included in the study. Serological markers of oxidative stress and antioxidant defence, blood pressure, routine biochemical, and anthropometric parameters were analyzed at baseline and after twelve weeks of regular chokeberry juice consumption. Significant decrease in thiobarbituric acid-reactive substances level (TBARS; P  lt  .001) and pro-oxidant-antioxidant balance (PAB; P  lt  .05), as well as increase in paroxonase-1 activity toward diazoxon (P  lt  .01) were found. Total oxidative status and sulphydryl groups levels were not significantly influenced by the intervention. Anthropometric, biochemical parameters, and blood pressure values were within the referent values for all subjects and were not influenced by the chokeberry juice consumption. However, we found positive correlation between age, body mass index, waist circumference, body fat percent, blood pressure, and analyzed marker of lipid peroxidation, which was influenced by the consumption. In conclusion, the fine modulation of several antioxidant/pro-oxidant status biomarkers observed in healthy subjects indicates putative prophylactic effects of polyphenol-rich chokeberry juice and supports its importance as part of an optimal diet.
PB  - Mary Ann Liebert, Inc, New Rochelle
T2  - Journal of Medicinal Food
T1  - Effects of Polyphenol-Rich Chokeberry Juice on Antioxidant/Pro-Oxidant Status in Healthy Subjects
EP  - 874
IS  - 8
SP  - 869
VL  - 17
DO  - 10.1089/jmf.2013.0135
ER  - 

@article{
author = "Kardum, Nevena Đ. and Konić-Ristić, Aleksandra and Savikin, Katarina and Spasić, Slavica and Stefanović, Aleksandra and Ivanišević, Jasmina and Miljković, Milica",
year = "2014",
abstract = "Berry fruits are a rich source of polyphenols, especially anthocyanins: well-known potent anti-oxidant phytochemicals. The purpose of this study was to evaluate beneficial effects of long-term consumption of polyphenol-rich organic chokeberry juice on different markers of antioxidant/pro-oxidant status in healthy female volunteers. Twenty-nine women, aged 25-49, were included in the study. Serological markers of oxidative stress and antioxidant defence, blood pressure, routine biochemical, and anthropometric parameters were analyzed at baseline and after twelve weeks of regular chokeberry juice consumption. Significant decrease in thiobarbituric acid-reactive substances level (TBARS; P  lt  .001) and pro-oxidant-antioxidant balance (PAB; P  lt  .05), as well as increase in paroxonase-1 activity toward diazoxon (P  lt  .01) were found. Total oxidative status and sulphydryl groups levels were not significantly influenced by the intervention. Anthropometric, biochemical parameters, and blood pressure values were within the referent values for all subjects and were not influenced by the chokeberry juice consumption. However, we found positive correlation between age, body mass index, waist circumference, body fat percent, blood pressure, and analyzed marker of lipid peroxidation, which was influenced by the consumption. In conclusion, the fine modulation of several antioxidant/pro-oxidant status biomarkers observed in healthy subjects indicates putative prophylactic effects of polyphenol-rich chokeberry juice and supports its importance as part of an optimal diet.",
publisher = "Mary Ann Liebert, Inc, New Rochelle",
journal = "Journal of Medicinal Food",
title = "Effects of Polyphenol-Rich Chokeberry Juice on Antioxidant/Pro-Oxidant Status in Healthy Subjects",
pages = "874-869",
number = "8",
volume = "17",
doi = "10.1089/jmf.2013.0135"
}

Kardum, N. Đ., Konić-Ristić, A., Savikin, K., Spasić, S., Stefanović, A., Ivanišević, J.,& Miljković, M.. (2014). Effects of Polyphenol-Rich Chokeberry Juice on Antioxidant/Pro-Oxidant Status in Healthy Subjects. in Journal of Medicinal Food
Mary Ann Liebert, Inc, New Rochelle., 17(8), 869-874.
https://doi.org/10.1089/jmf.2013.0135

Kardum NĐ, Konić-Ristić A, Savikin K, Spasić S, Stefanović A, Ivanišević J, Miljković M. Effects of Polyphenol-Rich Chokeberry Juice on Antioxidant/Pro-Oxidant Status in Healthy Subjects. in Journal of Medicinal Food. 2014;17(8):869-874.
doi:10.1089/jmf.2013.0135 .

Kardum, Nevena Đ., Konić-Ristić, Aleksandra, Savikin, Katarina, Spasić, Slavica, Stefanović, Aleksandra, Ivanišević, Jasmina, Miljković, Milica, "Effects of Polyphenol-Rich Chokeberry Juice on Antioxidant/Pro-Oxidant Status in Healthy Subjects" in Journal of Medicinal Food, 17, no. 8 (2014):869-874,
https://doi.org/10.1089/jmf.2013.0135 . .

TY  - JOUR
AU  - Gurinović, Mirjana
AU  - Ristić-Medić, Danijela
AU  - Vučić, Vesna M.
AU  - Milešević, Jelena
AU  - Konić-Ristić, Aleksandra
AU  - Glibetić, Marija
PY  - 2013
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/515
AB  - In development of cardiovascular disease (CVD) unhealthy diet and physical inactivity have an important role. According to World Health Organization (WHO), in development of atherosclerosis and CVD a major nutritive risk factor is nutrition with high energy intake in regard to expenditure, with higher intake of total fats, saturated and trans fatty acids, cholesterol, refined carbohydrates, table salt and alcohol, and inadequate intake of complex carbohydrates, dietary fibers, polyunsaturated fatty acids and antioxidants. WHO analysis of global burden of disease and risk factors for development of CVD in Europe found that among ten major risk factors, seven are related to nutrition and physical inactivity. In order to prevent CVD, WHO and European Heart Network (EHN) propose population goals in nutrition: total fats below 30% energy (E), saturated fatty acids (SFA)  lt 10% E, polyunsaturated fatty acids (PUFA) 6-11% E (n-6 PUFA 5-8% E, n-3 PUFA 1-2% E), trans fatty acids  lt 1% E, carbohydrates over 55% E, added sugar  lt 10% E, protein 10-15% E, cholesterol  lt 300 mg/day, table salt  lt 5 g/day (Na lt  2 g/day), fruits and vegetables  gt 400 g/ day. Daily moderate physical activity is recommended on daily basis at least one hour with average body mass index (BMI) on population level up to 21 kg/m2 i.e. for individuals in range of 18.5-24.9 kg/m2, while it is recommended for adult not to increase their body weight for more than 5 kg. This review focused on the most important nutritive risk factors for development of CVD.
AB  - U razvoju kardiovaskularnih bolesti (KVB) značajnu ulogu imaju nepravilna ishrana i fizička neaktivnost. Prema Svetskoj Zdravstvenoj Organizaciji (SZO) u nastanku ateroskleroze i KVB glavni nutritivni faktori rizika su ishrana sa visokim unosom energije u odnosu na potrošnju, zatim povećan unos ukupnih masti, zasićenih i trans masnih kiselina, holesterola, rafiniranih ugljenih hidrata, kuhinjske soli i alkohola, a nedovoljan unos složenih ugljenih hidrata, biljnih dijetnih vlakana, polinezasićenih masnih kiselina i antioksidativnih nutrijenata. Analiza SZO o globalnoj težini bolesti i faktorima rizika koji doprinose nastanku KVB u Evropi utvrdila je da od deset vodećih faktora rizika, sedam faktora se odnosi na ishranu i fizičku neaktivnost. U cilju prevencije KVB, SZO i European Heart Network (EHN) predlažu populacione ciljeve ishrane: ukupne masti da budu zastupljene ispod 30% energetske vrednosti (EV), zasićene masne kiseline  lt  10% EV, polinezasićene masne kiseline 6-11% EV (od toga n-6 5-8% EV, a n-3 1-2% EV), trans masne kiseline  lt  1% EV, ugljeni hidrati iznad 55% EV, prosti šećeri  lt  10% EV, proteini 10-15% EV, holesterol  lt  300 mg/dan, kuhinjska so  lt  5 g/dan (Na  lt  2 g/dan), voće i povrće  gt  400 g/dan. Preporučuje se i svakodnevna umerena fizička aktivnost u trajanju sat vremena uz prosečni index telesne mase (BMI) na nivou populacije 21 kg/m2 tj. za pojedince 18,5-24,9 kg/m2, pri čemu ne bi trebala u odraslom dobu da se povisi telesna masa za više od 5 kg . U ovom radu dat je pregled najvažnijih nutritivnih faktora rizika za nastanak KVB.
PB  - Klinički centar Srbije, Beograd
T2  - Acta clinica
T1  - Nutrition and cardiovascular disease
T1  - Ishrana i kardiovaskularne bolesti
EP  - 180
IS  - 1
SP  - 156
VL  - 13
UR  - https://hdl.handle.net/21.15107/rcub_rimi_515
ER  - 

@article{
author = "Gurinović, Mirjana and Ristić-Medić, Danijela and Vučić, Vesna M. and Milešević, Jelena and Konić-Ristić, Aleksandra and Glibetić, Marija",
year = "2013",
abstract = "In development of cardiovascular disease (CVD) unhealthy diet and physical inactivity have an important role. According to World Health Organization (WHO), in development of atherosclerosis and CVD a major nutritive risk factor is nutrition with high energy intake in regard to expenditure, with higher intake of total fats, saturated and trans fatty acids, cholesterol, refined carbohydrates, table salt and alcohol, and inadequate intake of complex carbohydrates, dietary fibers, polyunsaturated fatty acids and antioxidants. WHO analysis of global burden of disease and risk factors for development of CVD in Europe found that among ten major risk factors, seven are related to nutrition and physical inactivity. In order to prevent CVD, WHO and European Heart Network (EHN) propose population goals in nutrition: total fats below 30% energy (E), saturated fatty acids (SFA)  lt 10% E, polyunsaturated fatty acids (PUFA) 6-11% E (n-6 PUFA 5-8% E, n-3 PUFA 1-2% E), trans fatty acids  lt 1% E, carbohydrates over 55% E, added sugar  lt 10% E, protein 10-15% E, cholesterol  lt 300 mg/day, table salt  lt 5 g/day (Na lt  2 g/day), fruits and vegetables  gt 400 g/ day. Daily moderate physical activity is recommended on daily basis at least one hour with average body mass index (BMI) on population level up to 21 kg/m2 i.e. for individuals in range of 18.5-24.9 kg/m2, while it is recommended for adult not to increase their body weight for more than 5 kg. This review focused on the most important nutritive risk factors for development of CVD., U razvoju kardiovaskularnih bolesti (KVB) značajnu ulogu imaju nepravilna ishrana i fizička neaktivnost. Prema Svetskoj Zdravstvenoj Organizaciji (SZO) u nastanku ateroskleroze i KVB glavni nutritivni faktori rizika su ishrana sa visokim unosom energije u odnosu na potrošnju, zatim povećan unos ukupnih masti, zasićenih i trans masnih kiselina, holesterola, rafiniranih ugljenih hidrata, kuhinjske soli i alkohola, a nedovoljan unos složenih ugljenih hidrata, biljnih dijetnih vlakana, polinezasićenih masnih kiselina i antioksidativnih nutrijenata. Analiza SZO o globalnoj težini bolesti i faktorima rizika koji doprinose nastanku KVB u Evropi utvrdila je da od deset vodećih faktora rizika, sedam faktora se odnosi na ishranu i fizičku neaktivnost. U cilju prevencije KVB, SZO i European Heart Network (EHN) predlažu populacione ciljeve ishrane: ukupne masti da budu zastupljene ispod 30% energetske vrednosti (EV), zasićene masne kiseline  lt  10% EV, polinezasićene masne kiseline 6-11% EV (od toga n-6 5-8% EV, a n-3 1-2% EV), trans masne kiseline  lt  1% EV, ugljeni hidrati iznad 55% EV, prosti šećeri  lt  10% EV, proteini 10-15% EV, holesterol  lt  300 mg/dan, kuhinjska so  lt  5 g/dan (Na  lt  2 g/dan), voće i povrće  gt  400 g/dan. Preporučuje se i svakodnevna umerena fizička aktivnost u trajanju sat vremena uz prosečni index telesne mase (BMI) na nivou populacije 21 kg/m2 tj. za pojedince 18,5-24,9 kg/m2, pri čemu ne bi trebala u odraslom dobu da se povisi telesna masa za više od 5 kg . U ovom radu dat je pregled najvažnijih nutritivnih faktora rizika za nastanak KVB.",
publisher = "Klinički centar Srbije, Beograd",
journal = "Acta clinica",
title = "Nutrition and cardiovascular disease, Ishrana i kardiovaskularne bolesti",
pages = "180-156",
number = "1",
volume = "13",
url = "https://hdl.handle.net/21.15107/rcub_rimi_515"
}

Gurinović, M., Ristić-Medić, D., Vučić, V. M., Milešević, J., Konić-Ristić, A.,& Glibetić, M.. (2013). Nutrition and cardiovascular disease. in Acta clinica
Klinički centar Srbije, Beograd., 13(1), 156-180.
https://hdl.handle.net/21.15107/rcub_rimi_515

Gurinović M, Ristić-Medić D, Vučić VM, Milešević J, Konić-Ristić A, Glibetić M. Nutrition and cardiovascular disease. in Acta clinica. 2013;13(1):156-180.
https://hdl.handle.net/21.15107/rcub_rimi_515 .

Gurinović, Mirjana, Ristić-Medić, Danijela, Vučić, Vesna M., Milešević, Jelena, Konić-Ristić, Aleksandra, Glibetić, Marija, "Nutrition and cardiovascular disease" in Acta clinica, 13, no. 1 (2013):156-180,
https://hdl.handle.net/21.15107/rcub_rimi_515 .

TY  - JOUR
AU  - Konić-Ristić, Aleksandra
AU  - Srdić-Rajić, Tatjana
AU  - Kardum, Nevena Đ.
AU  - Glibetić, Marija
PY  - 2013
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/469
AB  - The beneficial effects of black chokeberry fruits and juices in health promotion and prevention of chronic diseases shown in both epidemiological and dietary intervention studies are often connected with their antioxidant activity. The aim of this study was to investigate the total phenolics and anthocyanins content, chemical antioxidant activity (DPPH-assay), antioxidant protection in erythrocytes and anti-platelet activity in vitro of three different chokeberry products: commercial and fresh pure chokeberry juice and a crude lyophilized water-ethanol extract of chokeberry fruits, as part of their pre-clinical evaluation. The obtained results indicated differences in chemical composition and antioxidant activity of the investigated products. Cellular effects, including both in vitro anti-platelet and antioxidant effects, were not directly correlated with the chemical antioxidant activity and the results obtained in vitro for antiplatelet effects were only partially consistent with the results obtained in vivo, in a pilot intervention trial. In conclusion, chemical analyses and in vitro experiments on foods and their bioactive substances are a valuable pre-screening tool for the evaluation of their biological activity. However, extrapolation of the obtained results to the in vivo settings is often limited and influenced by the bioavailability and metabolism of native dietary compounds or interactions with differrent molecules within the human body.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Biological activity of Aronia melanocarpa antioxidants pre-screening in an intervention study design
EP  - 443
IS  - 3
SP  - 429
VL  - 78
DO  - 10.2298/JSC121213020K
ER  - 

@article{
author = "Konić-Ristić, Aleksandra and Srdić-Rajić, Tatjana and Kardum, Nevena Đ. and Glibetić, Marija",
year = "2013",
abstract = "The beneficial effects of black chokeberry fruits and juices in health promotion and prevention of chronic diseases shown in both epidemiological and dietary intervention studies are often connected with their antioxidant activity. The aim of this study was to investigate the total phenolics and anthocyanins content, chemical antioxidant activity (DPPH-assay), antioxidant protection in erythrocytes and anti-platelet activity in vitro of three different chokeberry products: commercial and fresh pure chokeberry juice and a crude lyophilized water-ethanol extract of chokeberry fruits, as part of their pre-clinical evaluation. The obtained results indicated differences in chemical composition and antioxidant activity of the investigated products. Cellular effects, including both in vitro anti-platelet and antioxidant effects, were not directly correlated with the chemical antioxidant activity and the results obtained in vitro for antiplatelet effects were only partially consistent with the results obtained in vivo, in a pilot intervention trial. In conclusion, chemical analyses and in vitro experiments on foods and their bioactive substances are a valuable pre-screening tool for the evaluation of their biological activity. However, extrapolation of the obtained results to the in vivo settings is often limited and influenced by the bioavailability and metabolism of native dietary compounds or interactions with differrent molecules within the human body.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Biological activity of Aronia melanocarpa antioxidants pre-screening in an intervention study design",
pages = "443-429",
number = "3",
volume = "78",
doi = "10.2298/JSC121213020K"
}

Konić-Ristić, A., Srdić-Rajić, T., Kardum, N. Đ.,& Glibetić, M.. (2013). Biological activity of Aronia melanocarpa antioxidants pre-screening in an intervention study design. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 78(3), 429-443.
https://doi.org/10.2298/JSC121213020K

Konić-Ristić A, Srdić-Rajić T, Kardum NĐ, Glibetić M. Biological activity of Aronia melanocarpa antioxidants pre-screening in an intervention study design. in Journal of the Serbian Chemical Society. 2013;78(3):429-443.
doi:10.2298/JSC121213020K .

Konić-Ristić, Aleksandra, Srdić-Rajić, Tatjana, Kardum, Nevena Đ., Glibetić, Marija, "Biological activity of Aronia melanocarpa antioxidants pre-screening in an intervention study design" in Journal of the Serbian Chemical Society, 78, no. 3 (2013):429-443,
https://doi.org/10.2298/JSC121213020K . .

TY  - JOUR
AU  - Hollands, Wendy J.
AU  - Saha, Shikha
AU  - Hayran, Osman
AU  - Boyko, Nadiya
AU  - Glibetić, Marija
AU  - Konić-Ristić, Aleksandra
AU  - Jorjadze, Mariam
AU  - Kroon, Paul A.
PY  - 2013
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/478
AB  - BACKGROUNDThe health benefits of fruit and vegetable-rich diets may be partly due to modulation of platelet activity by bioactive phytochemicals. The aim of this study was to investigate the effects of bioactive-rich plant extracts and isolated bioactive metabolites on platelet function. Blood samples (n =15 subjects) were treated with extracts of bioactive-rich plants consumed as traditional foods in the Black Sea region, or with human metabolites of the bioactives quercetin and sulforaphane. Platelet function was assessed using the PFA-100. RESULTSNone of the extracts containing various flavonoids, glucosinolates and other bioactives, or isolated bioactive metabolites of quercetin or sulforaphane, caused significant changes in PFA-100 closure time (CT). In contrast, the positive controls (aspirin and Abciximab) consistently caused significant increases in CT for the platelet agonists epinephrine and ADP, respectively. CONCLUSIONThese data do not support the notion that these plant bioactives can improve human platelet function.
PB  - Wiley, Hoboken
T2  - Journal of the Science of Food & Agriculture
T1  - Lack of effect of bioactive-rich extracts of pomegranate, persimmon, nettle, dill, kale and Sideritis and isolated bioactives on platelet function
EP  - 3594
IS  - 14
SP  - 3588
VL  - 93
DO  - 10.1002/jsfa.6213
ER  - 

@article{
author = "Hollands, Wendy J. and Saha, Shikha and Hayran, Osman and Boyko, Nadiya and Glibetić, Marija and Konić-Ristić, Aleksandra and Jorjadze, Mariam and Kroon, Paul A.",
year = "2013",
abstract = "BACKGROUNDThe health benefits of fruit and vegetable-rich diets may be partly due to modulation of platelet activity by bioactive phytochemicals. The aim of this study was to investigate the effects of bioactive-rich plant extracts and isolated bioactive metabolites on platelet function. Blood samples (n =15 subjects) were treated with extracts of bioactive-rich plants consumed as traditional foods in the Black Sea region, or with human metabolites of the bioactives quercetin and sulforaphane. Platelet function was assessed using the PFA-100. RESULTSNone of the extracts containing various flavonoids, glucosinolates and other bioactives, or isolated bioactive metabolites of quercetin or sulforaphane, caused significant changes in PFA-100 closure time (CT). In contrast, the positive controls (aspirin and Abciximab) consistently caused significant increases in CT for the platelet agonists epinephrine and ADP, respectively. CONCLUSIONThese data do not support the notion that these plant bioactives can improve human platelet function.",
publisher = "Wiley, Hoboken",
journal = "Journal of the Science of Food & Agriculture",
title = "Lack of effect of bioactive-rich extracts of pomegranate, persimmon, nettle, dill, kale and Sideritis and isolated bioactives on platelet function",
pages = "3594-3588",
number = "14",
volume = "93",
doi = "10.1002/jsfa.6213"
}

Hollands, W. J., Saha, S., Hayran, O., Boyko, N., Glibetić, M., Konić-Ristić, A., Jorjadze, M.,& Kroon, P. A.. (2013). Lack of effect of bioactive-rich extracts of pomegranate, persimmon, nettle, dill, kale and Sideritis and isolated bioactives on platelet function. in Journal of the Science of Food & Agriculture
Wiley, Hoboken., 93(14), 3588-3594.
https://doi.org/10.1002/jsfa.6213

Hollands WJ, Saha S, Hayran O, Boyko N, Glibetić M, Konić-Ristić A, Jorjadze M, Kroon PA. Lack of effect of bioactive-rich extracts of pomegranate, persimmon, nettle, dill, kale and Sideritis and isolated bioactives on platelet function. in Journal of the Science of Food & Agriculture. 2013;93(14):3588-3594.
doi:10.1002/jsfa.6213 .

Hollands, Wendy J., Saha, Shikha, Hayran, Osman, Boyko, Nadiya, Glibetić, Marija, Konić-Ristić, Aleksandra, Jorjadze, Mariam, Kroon, Paul A., "Lack of effect of bioactive-rich extracts of pomegranate, persimmon, nettle, dill, kale and Sideritis and isolated bioactives on platelet function" in Journal of the Science of Food & Agriculture, 93, no. 14 (2013):3588-3594,
https://doi.org/10.1002/jsfa.6213 . .

TY  - JOUR
AU  - Woodcock, Mark E.
AU  - Hollands, Wendy J.
AU  - Konić-Ristić, Aleksandra
AU  - Glibetić, Marija
AU  - Boyko, Nadiya
AU  - Kocaoglu, Bike
AU  - Kroon, Paul A.
PY  - 2013
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/479
AB  - BACKGROUNDThere is increasing evidence that consumption of plant bioactives such as polyphenols and glucosinolates reduces cardiovascular disease risk and improves endothelial function. In the Black Sea area, a number of plants are consumed alone and as ingredients in traditional foods, and dill, nettle, kale, Sideritis and persimmon were identified as bioactive-rich traditional food plants. The present study investigated the effects of plant extracts on cellular markers of endothelial function (eNOS activation and expression and ET-1 secretion). RESULTSTreatment of human umbilical vein endothelial cells with persimmon extract significantly increased Akt and eNOS phosphorylation and nitric oxide metabolites and significantly decreased secretion of ET-1 to the media after 24 h compared with a vehicle control (all P  lt  0.01). None of the other plant extracts significantly altered any markers of endothelial function. CONCLUSIONThese findings suggest that persimmon fruit contains bioactives that can improve endothelial function via activation of eNOS and reduction in ET-1 secretion, but that dill, kale, Sideritis and nettle do not.
PB  - Wiley, Hoboken
T2  - Journal of the Science of Food & Agriculture
T1  - Bioactive-rich extracts of persimmon, but not nettle, Sideritis, dill or kale, increase eNOS activation and NO bioavailability and decrease endothelin-1 secretion by human vascular endothelial cells
EP  - 3580
IS  - 14
SP  - 3574
VL  - 93
DO  - 10.1002/jsfa.6251
ER  - 

@article{
author = "Woodcock, Mark E. and Hollands, Wendy J. and Konić-Ristić, Aleksandra and Glibetić, Marija and Boyko, Nadiya and Kocaoglu, Bike and Kroon, Paul A.",
year = "2013",
abstract = "BACKGROUNDThere is increasing evidence that consumption of plant bioactives such as polyphenols and glucosinolates reduces cardiovascular disease risk and improves endothelial function. In the Black Sea area, a number of plants are consumed alone and as ingredients in traditional foods, and dill, nettle, kale, Sideritis and persimmon were identified as bioactive-rich traditional food plants. The present study investigated the effects of plant extracts on cellular markers of endothelial function (eNOS activation and expression and ET-1 secretion). RESULTSTreatment of human umbilical vein endothelial cells with persimmon extract significantly increased Akt and eNOS phosphorylation and nitric oxide metabolites and significantly decreased secretion of ET-1 to the media after 24 h compared with a vehicle control (all P  lt  0.01). None of the other plant extracts significantly altered any markers of endothelial function. CONCLUSIONThese findings suggest that persimmon fruit contains bioactives that can improve endothelial function via activation of eNOS and reduction in ET-1 secretion, but that dill, kale, Sideritis and nettle do not.",
publisher = "Wiley, Hoboken",
journal = "Journal of the Science of Food & Agriculture",
title = "Bioactive-rich extracts of persimmon, but not nettle, Sideritis, dill or kale, increase eNOS activation and NO bioavailability and decrease endothelin-1 secretion by human vascular endothelial cells",
pages = "3580-3574",
number = "14",
volume = "93",
doi = "10.1002/jsfa.6251"
}

Woodcock, M. E., Hollands, W. J., Konić-Ristić, A., Glibetić, M., Boyko, N., Kocaoglu, B.,& Kroon, P. A.. (2013). Bioactive-rich extracts of persimmon, but not nettle, Sideritis, dill or kale, increase eNOS activation and NO bioavailability and decrease endothelin-1 secretion by human vascular endothelial cells. in Journal of the Science of Food & Agriculture
Wiley, Hoboken., 93(14), 3574-3580.
https://doi.org/10.1002/jsfa.6251

Woodcock ME, Hollands WJ, Konić-Ristić A, Glibetić M, Boyko N, Kocaoglu B, Kroon PA. Bioactive-rich extracts of persimmon, but not nettle, Sideritis, dill or kale, increase eNOS activation and NO bioavailability and decrease endothelin-1 secretion by human vascular endothelial cells. in Journal of the Science of Food & Agriculture. 2013;93(14):3574-3580.
doi:10.1002/jsfa.6251 .

Woodcock, Mark E., Hollands, Wendy J., Konić-Ristić, Aleksandra, Glibetić, Marija, Boyko, Nadiya, Kocaoglu, Bike, Kroon, Paul A., "Bioactive-rich extracts of persimmon, but not nettle, Sideritis, dill or kale, increase eNOS activation and NO bioavailability and decrease endothelin-1 secretion by human vascular endothelial cells" in Journal of the Science of Food & Agriculture, 93, no. 14 (2013):3574-3580,
https://doi.org/10.1002/jsfa.6251 . .

TY  - JOUR
AU  - Danesi, Francesca
AU  - Saha, Shikha
AU  - Kroon, Paul A.
AU  - Glibetić, Marija
AU  - Konić-Ristić, Aleksandra
AU  - D'Antuono, Luigi F.
AU  - Bordoni, Alessandra
PY  - 2013
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/480
AB  - BACKGROUNDIn several countries, tea (hot-water infusions of dried Camellia sinensis (CS) leaves) is a major source of antioxidant flavonoids, and its consumption has been associated with several favourable outcomes. Other plants used for the preparation of herbal teas are sources of phenolic antioxidant compounds; among them Sideritis scardica (SS) is used for the preparation of a popular drink throughout Eastern and Central Europe. We have compared the effects of an SS extract to a CS extract in HepG2 cells to set the scientific basis for the exploitation of other herbal teas in counteraction of oxidative stress. RESULTSAlthough SS extract had a lower phenolic concentration and total antioxidant capacity than CS extract, their cellular antioxidant effects were similar. The different phenolic pattern of the extracts suggests that the protective activity is not limited to catechins. CONCLUSIONAlthough further research is needed, our data represent a first contribution for the evaluation of the potential effect of SS in increasing antioxidant defences.
PB  - Wiley, Hoboken
T2  - Journal of the Science of Food & Agriculture
T1  - Bioactive-rich Sideritis scardica tea (mountain tea) is as potent as Camellia sinensis tea at inducing cellular antioxidant defences and preventing oxidative stress
EP  - 3564
IS  - 14
SP  - 3558
VL  - 93
DO  - 10.1002/jsfa.6214
ER  - 

@article{
author = "Danesi, Francesca and Saha, Shikha and Kroon, Paul A. and Glibetić, Marija and Konić-Ristić, Aleksandra and D'Antuono, Luigi F. and Bordoni, Alessandra",
year = "2013",
abstract = "BACKGROUNDIn several countries, tea (hot-water infusions of dried Camellia sinensis (CS) leaves) is a major source of antioxidant flavonoids, and its consumption has been associated with several favourable outcomes. Other plants used for the preparation of herbal teas are sources of phenolic antioxidant compounds; among them Sideritis scardica (SS) is used for the preparation of a popular drink throughout Eastern and Central Europe. We have compared the effects of an SS extract to a CS extract in HepG2 cells to set the scientific basis for the exploitation of other herbal teas in counteraction of oxidative stress. RESULTSAlthough SS extract had a lower phenolic concentration and total antioxidant capacity than CS extract, their cellular antioxidant effects were similar. The different phenolic pattern of the extracts suggests that the protective activity is not limited to catechins. CONCLUSIONAlthough further research is needed, our data represent a first contribution for the evaluation of the potential effect of SS in increasing antioxidant defences.",
publisher = "Wiley, Hoboken",
journal = "Journal of the Science of Food & Agriculture",
title = "Bioactive-rich Sideritis scardica tea (mountain tea) is as potent as Camellia sinensis tea at inducing cellular antioxidant defences and preventing oxidative stress",
pages = "3564-3558",
number = "14",
volume = "93",
doi = "10.1002/jsfa.6214"
}

Danesi, F., Saha, S., Kroon, P. A., Glibetić, M., Konić-Ristić, A., D'Antuono, L. F.,& Bordoni, A.. (2013). Bioactive-rich Sideritis scardica tea (mountain tea) is as potent as Camellia sinensis tea at inducing cellular antioxidant defences and preventing oxidative stress. in Journal of the Science of Food & Agriculture
Wiley, Hoboken., 93(14), 3558-3564.
https://doi.org/10.1002/jsfa.6214

Danesi F, Saha S, Kroon PA, Glibetić M, Konić-Ristić A, D'Antuono LF, Bordoni A. Bioactive-rich Sideritis scardica tea (mountain tea) is as potent as Camellia sinensis tea at inducing cellular antioxidant defences and preventing oxidative stress. in Journal of the Science of Food & Agriculture. 2013;93(14):3558-3564.
doi:10.1002/jsfa.6214 .

Danesi, Francesca, Saha, Shikha, Kroon, Paul A., Glibetić, Marija, Konić-Ristić, Aleksandra, D'Antuono, Luigi F., Bordoni, Alessandra, "Bioactive-rich Sideritis scardica tea (mountain tea) is as potent as Camellia sinensis tea at inducing cellular antioxidant defences and preventing oxidative stress" in Journal of the Science of Food & Agriculture, 93, no. 14 (2013):3558-3564,
https://doi.org/10.1002/jsfa.6214 . .