TY  - JOUR
AU  - Hollands, Wendy J.
AU  - Saha, Shikha
AU  - Hayran, Osman
AU  - Boyko, Nadiya
AU  - Glibetić, Marija
AU  - Konić-Ristić, Aleksandra
AU  - Jorjadze, Mariam
AU  - Kroon, Paul A.
PY  - 2013
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/478
AB  - BACKGROUNDThe health benefits of fruit and vegetable-rich diets may be partly due to modulation of platelet activity by bioactive phytochemicals. The aim of this study was to investigate the effects of bioactive-rich plant extracts and isolated bioactive metabolites on platelet function. Blood samples (n =15 subjects) were treated with extracts of bioactive-rich plants consumed as traditional foods in the Black Sea region, or with human metabolites of the bioactives quercetin and sulforaphane. Platelet function was assessed using the PFA-100. RESULTSNone of the extracts containing various flavonoids, glucosinolates and other bioactives, or isolated bioactive metabolites of quercetin or sulforaphane, caused significant changes in PFA-100 closure time (CT). In contrast, the positive controls (aspirin and Abciximab) consistently caused significant increases in CT for the platelet agonists epinephrine and ADP, respectively. CONCLUSIONThese data do not support the notion that these plant bioactives can improve human platelet function.
PB  - Wiley, Hoboken
T2  - Journal of the Science of Food & Agriculture
T1  - Lack of effect of bioactive-rich extracts of pomegranate, persimmon, nettle, dill, kale and Sideritis and isolated bioactives on platelet function
EP  - 3594
IS  - 14
SP  - 3588
VL  - 93
DO  - 10.1002/jsfa.6213
ER  - 

@article{
author = "Hollands, Wendy J. and Saha, Shikha and Hayran, Osman and Boyko, Nadiya and Glibetić, Marija and Konić-Ristić, Aleksandra and Jorjadze, Mariam and Kroon, Paul A.",
year = "2013",
abstract = "BACKGROUNDThe health benefits of fruit and vegetable-rich diets may be partly due to modulation of platelet activity by bioactive phytochemicals. The aim of this study was to investigate the effects of bioactive-rich plant extracts and isolated bioactive metabolites on platelet function. Blood samples (n =15 subjects) were treated with extracts of bioactive-rich plants consumed as traditional foods in the Black Sea region, or with human metabolites of the bioactives quercetin and sulforaphane. Platelet function was assessed using the PFA-100. RESULTSNone of the extracts containing various flavonoids, glucosinolates and other bioactives, or isolated bioactive metabolites of quercetin or sulforaphane, caused significant changes in PFA-100 closure time (CT). In contrast, the positive controls (aspirin and Abciximab) consistently caused significant increases in CT for the platelet agonists epinephrine and ADP, respectively. CONCLUSIONThese data do not support the notion that these plant bioactives can improve human platelet function.",
publisher = "Wiley, Hoboken",
journal = "Journal of the Science of Food & Agriculture",
title = "Lack of effect of bioactive-rich extracts of pomegranate, persimmon, nettle, dill, kale and Sideritis and isolated bioactives on platelet function",
pages = "3594-3588",
number = "14",
volume = "93",
doi = "10.1002/jsfa.6213"
}

Hollands, W. J., Saha, S., Hayran, O., Boyko, N., Glibetić, M., Konić-Ristić, A., Jorjadze, M.,& Kroon, P. A.. (2013). Lack of effect of bioactive-rich extracts of pomegranate, persimmon, nettle, dill, kale and Sideritis and isolated bioactives on platelet function. in Journal of the Science of Food & Agriculture
Wiley, Hoboken., 93(14), 3588-3594.
https://doi.org/10.1002/jsfa.6213

Hollands WJ, Saha S, Hayran O, Boyko N, Glibetić M, Konić-Ristić A, Jorjadze M, Kroon PA. Lack of effect of bioactive-rich extracts of pomegranate, persimmon, nettle, dill, kale and Sideritis and isolated bioactives on platelet function. in Journal of the Science of Food & Agriculture. 2013;93(14):3588-3594.
doi:10.1002/jsfa.6213 .

Hollands, Wendy J., Saha, Shikha, Hayran, Osman, Boyko, Nadiya, Glibetić, Marija, Konić-Ristić, Aleksandra, Jorjadze, Mariam, Kroon, Paul A., "Lack of effect of bioactive-rich extracts of pomegranate, persimmon, nettle, dill, kale and Sideritis and isolated bioactives on platelet function" in Journal of the Science of Food & Agriculture, 93, no. 14 (2013):3588-3594,
https://doi.org/10.1002/jsfa.6213 . .

TY  - JOUR
AU  - Danesi, Francesca
AU  - Saha, Shikha
AU  - Kroon, Paul A.
AU  - Glibetić, Marija
AU  - Konić-Ristić, Aleksandra
AU  - D'Antuono, Luigi F.
AU  - Bordoni, Alessandra
PY  - 2013
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/480
AB  - BACKGROUNDIn several countries, tea (hot-water infusions of dried Camellia sinensis (CS) leaves) is a major source of antioxidant flavonoids, and its consumption has been associated with several favourable outcomes. Other plants used for the preparation of herbal teas are sources of phenolic antioxidant compounds; among them Sideritis scardica (SS) is used for the preparation of a popular drink throughout Eastern and Central Europe. We have compared the effects of an SS extract to a CS extract in HepG2 cells to set the scientific basis for the exploitation of other herbal teas in counteraction of oxidative stress. RESULTSAlthough SS extract had a lower phenolic concentration and total antioxidant capacity than CS extract, their cellular antioxidant effects were similar. The different phenolic pattern of the extracts suggests that the protective activity is not limited to catechins. CONCLUSIONAlthough further research is needed, our data represent a first contribution for the evaluation of the potential effect of SS in increasing antioxidant defences.
PB  - Wiley, Hoboken
T2  - Journal of the Science of Food & Agriculture
T1  - Bioactive-rich Sideritis scardica tea (mountain tea) is as potent as Camellia sinensis tea at inducing cellular antioxidant defences and preventing oxidative stress
EP  - 3564
IS  - 14
SP  - 3558
VL  - 93
DO  - 10.1002/jsfa.6214
ER  - 

@article{
author = "Danesi, Francesca and Saha, Shikha and Kroon, Paul A. and Glibetić, Marija and Konić-Ristić, Aleksandra and D'Antuono, Luigi F. and Bordoni, Alessandra",
year = "2013",
abstract = "BACKGROUNDIn several countries, tea (hot-water infusions of dried Camellia sinensis (CS) leaves) is a major source of antioxidant flavonoids, and its consumption has been associated with several favourable outcomes. Other plants used for the preparation of herbal teas are sources of phenolic antioxidant compounds; among them Sideritis scardica (SS) is used for the preparation of a popular drink throughout Eastern and Central Europe. We have compared the effects of an SS extract to a CS extract in HepG2 cells to set the scientific basis for the exploitation of other herbal teas in counteraction of oxidative stress. RESULTSAlthough SS extract had a lower phenolic concentration and total antioxidant capacity than CS extract, their cellular antioxidant effects were similar. The different phenolic pattern of the extracts suggests that the protective activity is not limited to catechins. CONCLUSIONAlthough further research is needed, our data represent a first contribution for the evaluation of the potential effect of SS in increasing antioxidant defences.",
publisher = "Wiley, Hoboken",
journal = "Journal of the Science of Food & Agriculture",
title = "Bioactive-rich Sideritis scardica tea (mountain tea) is as potent as Camellia sinensis tea at inducing cellular antioxidant defences and preventing oxidative stress",
pages = "3564-3558",
number = "14",
volume = "93",
doi = "10.1002/jsfa.6214"
}

Danesi, F., Saha, S., Kroon, P. A., Glibetić, M., Konić-Ristić, A., D'Antuono, L. F.,& Bordoni, A.. (2013). Bioactive-rich Sideritis scardica tea (mountain tea) is as potent as Camellia sinensis tea at inducing cellular antioxidant defences and preventing oxidative stress. in Journal of the Science of Food & Agriculture
Wiley, Hoboken., 93(14), 3558-3564.
https://doi.org/10.1002/jsfa.6214

Danesi F, Saha S, Kroon PA, Glibetić M, Konić-Ristić A, D'Antuono LF, Bordoni A. Bioactive-rich Sideritis scardica tea (mountain tea) is as potent as Camellia sinensis tea at inducing cellular antioxidant defences and preventing oxidative stress. in Journal of the Science of Food & Agriculture. 2013;93(14):3558-3564.
doi:10.1002/jsfa.6214 .

Danesi, Francesca, Saha, Shikha, Kroon, Paul A., Glibetić, Marija, Konić-Ristić, Aleksandra, D'Antuono, Luigi F., Bordoni, Alessandra, "Bioactive-rich Sideritis scardica tea (mountain tea) is as potent as Camellia sinensis tea at inducing cellular antioxidant defences and preventing oxidative stress" in Journal of the Science of Food & Agriculture, 93, no. 14 (2013):3558-3564,
https://doi.org/10.1002/jsfa.6214 . .