TY  - JOUR
AU  - Paunović, Marija
AU  - Ristić-Medić, Danijela
AU  - Arsić, Aleksandra
AU  - Petrović, Snježana
AU  - Krstić, Predrag
AU  - Kojadinović, Milica
AU  - Vučić, Vesna
PY  - 2024
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1482
AB  - Background/Aim. Since the coronavirus disease 2019 (COVID-19) pandemic led to a strict lockdown in Serbia, the population has experienced drastic lifestyle changes. Physical distancing, self-isolation, limited availability of essential food products, and the stress related to the availability of therapy during the pandemic particularly affected the lives of vulnerable groups, such as breast cancer (BrC) patients. The aim of this study was to examine the changes in eating behaviors and physical activity of postmenopausal BrC patients on adjuvant hormonal therapy under the COVID-19 lockdown conditions. Methods. This observational retrospective pre-post cohort study included 32 women treated with aromatase inhibitors (AIs) who responded to telephone interviews using a structured questionnaire. The questionnaire aims to collect data on eating habits (intake of certain foods on a daily/weekly basis, as well as changes in the usual choice of food), intake of supplements, changes in weight, and physical activity before and during the lockdown. Results. The results showed that, due to problems in obtaining groceries, the patients cooked and consumed homemade sweets and fruit more often (47% of the respondents), while fewer (31%) consumed fresh fish. Nearly 41% of patients reported increased food intake, and 88% reported decreased physical activity, which led to an increase in body weight in as many as 47% of subjects. The intake of supplements was doubled. Conclusion. The COVID-19 lockdown with home confinement exacerbated health risks and affected dietary patterns and physical activity, which may have had a negative impact on the long-term health of BrC patients treated with AIs.
PB  - Military Medical Academy, INI
T2  - Vojnosanitetski pregled
T2  - Vojnosanitetski pregled
T1  - Eating behaviors and physical activity during the COVID-19 pandemic lockdown: Experiences of breast cancer patients on adjuvant hormonal therapy
EP  - xx
IS  - 00
SP  - xx
DO  - 10.2298/VSP231122020P
ER  - 

@article{
author = "Paunović, Marija and Ristić-Medić, Danijela and Arsić, Aleksandra and Petrović, Snježana and Krstić, Predrag and Kojadinović, Milica and Vučić, Vesna",
year = "2024",
abstract = "Background/Aim. Since the coronavirus disease 2019 (COVID-19) pandemic led to a strict lockdown in Serbia, the population has experienced drastic lifestyle changes. Physical distancing, self-isolation, limited availability of essential food products, and the stress related to the availability of therapy during the pandemic particularly affected the lives of vulnerable groups, such as breast cancer (BrC) patients. The aim of this study was to examine the changes in eating behaviors and physical activity of postmenopausal BrC patients on adjuvant hormonal therapy under the COVID-19 lockdown conditions. Methods. This observational retrospective pre-post cohort study included 32 women treated with aromatase inhibitors (AIs) who responded to telephone interviews using a structured questionnaire. The questionnaire aims to collect data on eating habits (intake of certain foods on a daily/weekly basis, as well as changes in the usual choice of food), intake of supplements, changes in weight, and physical activity before and during the lockdown. Results. The results showed that, due to problems in obtaining groceries, the patients cooked and consumed homemade sweets and fruit more often (47% of the respondents), while fewer (31%) consumed fresh fish. Nearly 41% of patients reported increased food intake, and 88% reported decreased physical activity, which led to an increase in body weight in as many as 47% of subjects. The intake of supplements was doubled. Conclusion. The COVID-19 lockdown with home confinement exacerbated health risks and affected dietary patterns and physical activity, which may have had a negative impact on the long-term health of BrC patients treated with AIs.",
publisher = "Military Medical Academy, INI",
journal = "Vojnosanitetski pregled, Vojnosanitetski pregled",
title = "Eating behaviors and physical activity during the COVID-19 pandemic lockdown: Experiences of breast cancer patients on adjuvant hormonal therapy",
pages = "xx-xx",
number = "00",
doi = "10.2298/VSP231122020P"
}

Paunović, M., Ristić-Medić, D., Arsić, A., Petrović, S., Krstić, P., Kojadinović, M.,& Vučić, V.. (2024). Eating behaviors and physical activity during the COVID-19 pandemic lockdown: Experiences of breast cancer patients on adjuvant hormonal therapy. in Vojnosanitetski pregled
Military Medical Academy, INI.(00), xx-xx.
https://doi.org/10.2298/VSP231122020P

Paunović M, Ristić-Medić D, Arsić A, Petrović S, Krstić P, Kojadinović M, Vučić V. Eating behaviors and physical activity during the COVID-19 pandemic lockdown: Experiences of breast cancer patients on adjuvant hormonal therapy. in Vojnosanitetski pregled. 2024;(00):xx-xx.
doi:10.2298/VSP231122020P .

Paunović, Marija, Ristić-Medić, Danijela, Arsić, Aleksandra, Petrović, Snježana, Krstić, Predrag, Kojadinović, Milica, Vučić, Vesna, "Eating behaviors and physical activity during the COVID-19 pandemic lockdown: Experiences of breast cancer patients on adjuvant hormonal therapy" in Vojnosanitetski pregled, no. 00 (2024):xx-xx,
https://doi.org/10.2298/VSP231122020P . .

TY  - CONF
AU  - Trivanović, Drenka
AU  - Vujačić, Marko
AU  - Arsić, Aleksandra
AU  - Bogosavljević, Nikola
AU  - Kovačić, Marijana
AU  - Drvenica, Ivana
AU  - Mojsilović, Slavko
AU  - Baščarević, Zoran
AU  - Bugarski, Diana
AU  - Jauković, Aleksandra
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1408
AB  - Bone marrow (BM) adipose tissue (BMAT) has been described as lipotoxic factor with negative impacts on skeletal system regeneration and repair. As BMAT undergoes metabolic and cellular 
adaptations with age and disease, we assumed that investigation of BMAT-associated lipid profile and cellularity at different skeletal locations in osteoarthritis (OA) patients might contribute to understanding of lipid involvement in OA development and progression.Acetabular and femoral BM, and femoral subcutaneous adipose tissue (fSAT) were obtained from 
matched patients (n=11, 5 women, 6 men; age: 65±11 years; BMI: 27.89±4.42 kg/m2) undergoing hip arthroplasty surgery (Ethical approval I-97/11). BM, BMAT and fSAT were explored at the levels of total lipids, fatty acids, and cells, by using thin layer and gas chromatography and ex vivo cellular 24734039, 2023, S3, Downloaded from https://asbmr.onlinelibrary.wiley.com/doi/10.1002/jbm4.10738 by Readcube (Labtiva Inc.), Wiley Online Library on [23/01/2024]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License assays. Statistical significance was estimated by non-parametric tests and Spearman’s rank correlation (r) was calculated.BMAT content was significantly higher in femoral (0.262±0.088 mL/g) than in acetabular BM (0.063±0.051 mL/g) (n=11, p=0.016). Negative associations with BMI of patients were found for femoral BM (r=-0.783, p=0.017, n=11) and BMAT (n=9, r=-1.000, p=0.017) tissue cellularity. 
Additionally, femoral BMAT cellularity declined with age (r=-0.675, n=10, p=0.037). Total lipid analyses revealed significantly lower triglyceride content in femoral than in acetabular BMAT and fSAT. Frequency of saturated palmitic, myristic and stearic acids were higher in femoral than in acetabular BMAT and fSAT, where palmitoleic, linoleic, oleic acids were more dominant. BMAT associated compartments from both locations host lower frequency of non-hematopoietic CD45- neutral lipid-loaded cells when compared to BM. This associated with higher incidence of clonogenic mesenchymal stromal (stem) cells in acetabular (0.032± 0.04%) and femoral (0.021± 0.028%) BMATs and fSAT (0.031 ± 0.016%) than in their BM counterparts.
Collectively, our results indicate that the lipid profiles of hip BMAT impose significantly different BM microenvironments and distribution of cells with regenerative potential in OA patients.
PB  - American Society for Bone and Mineral Research
C3  - JBMR PlusVolume 7: Abstracts of the 50th ECTS Congress featuring BRS Annual Meeting, 15-18 April 2023, Liverpool
T1  - Lipid and cellular profiles of acetabular and femoral bone marrow adipose tissues are distinct in hip osteoarthritis patients
IS  - 3
SP  - P140
VL  - 7
UR  - https://hdl.handle.net/21.15107/rcub_rimi_1408
ER  - 

@conference{
author = "Trivanović, Drenka and Vujačić, Marko and Arsić, Aleksandra and Bogosavljević, Nikola and Kovačić, Marijana and Drvenica, Ivana and Mojsilović, Slavko and Baščarević, Zoran and Bugarski, Diana and Jauković, Aleksandra",
year = "2023",
abstract = "Bone marrow (BM) adipose tissue (BMAT) has been described as lipotoxic factor with negative impacts on skeletal system regeneration and repair. As BMAT undergoes metabolic and cellular 
adaptations with age and disease, we assumed that investigation of BMAT-associated lipid profile and cellularity at different skeletal locations in osteoarthritis (OA) patients might contribute to understanding of lipid involvement in OA development and progression.Acetabular and femoral BM, and femoral subcutaneous adipose tissue (fSAT) were obtained from 
matched patients (n=11, 5 women, 6 men; age: 65±11 years; BMI: 27.89±4.42 kg/m2) undergoing hip arthroplasty surgery (Ethical approval I-97/11). BM, BMAT and fSAT were explored at the levels of total lipids, fatty acids, and cells, by using thin layer and gas chromatography and ex vivo cellular 24734039, 2023, S3, Downloaded from https://asbmr.onlinelibrary.wiley.com/doi/10.1002/jbm4.10738 by Readcube (Labtiva Inc.), Wiley Online Library on [23/01/2024]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License assays. Statistical significance was estimated by non-parametric tests and Spearman’s rank correlation (r) was calculated.BMAT content was significantly higher in femoral (0.262±0.088 mL/g) than in acetabular BM (0.063±0.051 mL/g) (n=11, p=0.016). Negative associations with BMI of patients were found for femoral BM (r=-0.783, p=0.017, n=11) and BMAT (n=9, r=-1.000, p=0.017) tissue cellularity. 
Additionally, femoral BMAT cellularity declined with age (r=-0.675, n=10, p=0.037). Total lipid analyses revealed significantly lower triglyceride content in femoral than in acetabular BMAT and fSAT. Frequency of saturated palmitic, myristic and stearic acids were higher in femoral than in acetabular BMAT and fSAT, where palmitoleic, linoleic, oleic acids were more dominant. BMAT associated compartments from both locations host lower frequency of non-hematopoietic CD45- neutral lipid-loaded cells when compared to BM. This associated with higher incidence of clonogenic mesenchymal stromal (stem) cells in acetabular (0.032± 0.04%) and femoral (0.021± 0.028%) BMATs and fSAT (0.031 ± 0.016%) than in their BM counterparts.
Collectively, our results indicate that the lipid profiles of hip BMAT impose significantly different BM microenvironments and distribution of cells with regenerative potential in OA patients.",
publisher = "American Society for Bone and Mineral Research",
journal = "JBMR PlusVolume 7: Abstracts of the 50th ECTS Congress featuring BRS Annual Meeting, 15-18 April 2023, Liverpool",
title = "Lipid and cellular profiles of acetabular and femoral bone marrow adipose tissues are distinct in hip osteoarthritis patients",
number = "3",
pages = "P140",
volume = "7",
url = "https://hdl.handle.net/21.15107/rcub_rimi_1408"
}

Trivanović, D., Vujačić, M., Arsić, A., Bogosavljević, N., Kovačić, M., Drvenica, I., Mojsilović, S., Baščarević, Z., Bugarski, D.,& Jauković, A.. (2023). Lipid and cellular profiles of acetabular and femoral bone marrow adipose tissues are distinct in hip osteoarthritis patients. in JBMR PlusVolume 7: Abstracts of the 50th ECTS Congress featuring BRS Annual Meeting, 15-18 April 2023, Liverpool
American Society for Bone and Mineral Research., 7(3), P140.
https://hdl.handle.net/21.15107/rcub_rimi_1408

Trivanović D, Vujačić M, Arsić A, Bogosavljević N, Kovačić M, Drvenica I, Mojsilović S, Baščarević Z, Bugarski D, Jauković A. Lipid and cellular profiles of acetabular and femoral bone marrow adipose tissues are distinct in hip osteoarthritis patients. in JBMR PlusVolume 7: Abstracts of the 50th ECTS Congress featuring BRS Annual Meeting, 15-18 April 2023, Liverpool. 2023;7(3):P140.
https://hdl.handle.net/21.15107/rcub_rimi_1408 .

Trivanović, Drenka, Vujačić, Marko, Arsić, Aleksandra, Bogosavljević, Nikola, Kovačić, Marijana, Drvenica, Ivana, Mojsilović, Slavko, Baščarević, Zoran, Bugarski, Diana, Jauković, Aleksandra, "Lipid and cellular profiles of acetabular and femoral bone marrow adipose tissues are distinct in hip osteoarthritis patients" in JBMR PlusVolume 7: Abstracts of the 50th ECTS Congress featuring BRS Annual Meeting, 15-18 April 2023, Liverpool, 7, no. 3 (2023):P140,
https://hdl.handle.net/21.15107/rcub_rimi_1408 .

TY  - JOUR
AU  - Paunović, Marija
AU  - Kotur-Stevuljević, Jelena
AU  - Arsić, Aleksandra
AU  - Milošević, Maja
AU  - Todorović, Vanja
AU  - Guzonjić, Azra
AU  - Vučić, Vesna M.
AU  - Petrović, Snježana
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1303
AB  - A Western-style diet, rich in fat and simple sugars, is the main risk factor for a significant number of chronic diseases and disorders, as well as for a progression of metabolic syndrome (MetS). One of the key mechanisms involved in MetS development is increased oxidative stress caused by the accumulation of body fat. Some dietary polyphenols have shown a protective role in preventing oxidative-stress-induced damage. We investigated the difference in the oxidative response of plasma, liver, and visceral adipose tissue in rats fed with a high-fat high-fructose (HFF) diet for ten weeks, and the effectiveness of polyphenol-rich juices (black currant (BC) and cornelian cherry (CC)) in HFF-diet-induced oxidative stress prevention. The most prominent impact of the HFF diet on redox parameters was recorded in the liver, whereas adipose tissue showed the most potent protection mechanisms against oxidative stress. Consumption of both juices decreased advanced oxidation protein product (AOPP) level in plasma, increased paraoxonase1 (PON1) activity in the liver, and significantly decreased total oxidative status (TOS) in adipose tissue. BC exerted stronger antioxidative potential than CC and decreased the superoxide anion radical (O2•−) level in the liver. It also reduced TOS, total antioxidative status (TAS), and malondialdehyde (MDA) concentration in adipose tissue. The multiple linear regression analysis has shown that the best predictors of MetS development, estimated through the increase in visceral adiposity, were superoxide dismutase (SOD), AOPP, TOS, and TAS. The consumption of polyphenol-rich juices may provide a convenient approach for the systemic reduction of oxidative stress parameters.
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Antioxidants
T1  - Antioxidative Effects of Black Currant and Cornelian Cherry Juices in Different Tissues of an Experimental Model of Metabolic Syndrome in Rats
IS  - 6
SP  - 1148
VL  - 12
DO  - 10.3390/antiox12061148
ER  - 

@article{
author = "Paunović, Marija and Kotur-Stevuljević, Jelena and Arsić, Aleksandra and Milošević, Maja and Todorović, Vanja and Guzonjić, Azra and Vučić, Vesna M. and Petrović, Snježana",
year = "2023",
abstract = "A Western-style diet, rich in fat and simple sugars, is the main risk factor for a significant number of chronic diseases and disorders, as well as for a progression of metabolic syndrome (MetS). One of the key mechanisms involved in MetS development is increased oxidative stress caused by the accumulation of body fat. Some dietary polyphenols have shown a protective role in preventing oxidative-stress-induced damage. We investigated the difference in the oxidative response of plasma, liver, and visceral adipose tissue in rats fed with a high-fat high-fructose (HFF) diet for ten weeks, and the effectiveness of polyphenol-rich juices (black currant (BC) and cornelian cherry (CC)) in HFF-diet-induced oxidative stress prevention. The most prominent impact of the HFF diet on redox parameters was recorded in the liver, whereas adipose tissue showed the most potent protection mechanisms against oxidative stress. Consumption of both juices decreased advanced oxidation protein product (AOPP) level in plasma, increased paraoxonase1 (PON1) activity in the liver, and significantly decreased total oxidative status (TOS) in adipose tissue. BC exerted stronger antioxidative potential than CC and decreased the superoxide anion radical (O2•−) level in the liver. It also reduced TOS, total antioxidative status (TAS), and malondialdehyde (MDA) concentration in adipose tissue. The multiple linear regression analysis has shown that the best predictors of MetS development, estimated through the increase in visceral adiposity, were superoxide dismutase (SOD), AOPP, TOS, and TAS. The consumption of polyphenol-rich juices may provide a convenient approach for the systemic reduction of oxidative stress parameters.",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Antioxidants",
title = "Antioxidative Effects of Black Currant and Cornelian Cherry Juices in Different Tissues of an Experimental Model of Metabolic Syndrome in Rats",
number = "6",
pages = "1148",
volume = "12",
doi = "10.3390/antiox12061148"
}

Paunović, M., Kotur-Stevuljević, J., Arsić, A., Milošević, M., Todorović, V., Guzonjić, A., Vučić, V. M.,& Petrović, S.. (2023). Antioxidative Effects of Black Currant and Cornelian Cherry Juices in Different Tissues of an Experimental Model of Metabolic Syndrome in Rats. in Antioxidants
Multidisciplinary Digital Publishing Institute (MDPI)., 12(6), 1148.
https://doi.org/10.3390/antiox12061148

Paunović M, Kotur-Stevuljević J, Arsić A, Milošević M, Todorović V, Guzonjić A, Vučić VM, Petrović S. Antioxidative Effects of Black Currant and Cornelian Cherry Juices in Different Tissues of an Experimental Model of Metabolic Syndrome in Rats. in Antioxidants. 2023;12(6):1148.
doi:10.3390/antiox12061148 .

Paunović, Marija, Kotur-Stevuljević, Jelena, Arsić, Aleksandra, Milošević, Maja, Todorović, Vanja, Guzonjić, Azra, Vučić, Vesna M., Petrović, Snježana, "Antioxidative Effects of Black Currant and Cornelian Cherry Juices in Different Tissues of an Experimental Model of Metabolic Syndrome in Rats" in Antioxidants, 12, no. 6 (2023):1148,
https://doi.org/10.3390/antiox12061148 . .

TY  - JOUR
AU  - Vučić, Vesna M.
AU  - Ristić-Medić, Danijela
AU  - Arsić, Aleksandra
AU  - Petrović, Snježana
AU  - Paunović, Marija
AU  - Vasiljević, Nađa
AU  - Ilich, Jasminka Z.
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1308
AB  - Osteosarcopenic adiposity (OSA) syndrome denotes the confluence of bone, muscle, and adipose tissue deterioration. Being a complex entity, numerous uncertainties about OSA still exist, despite the extensive research on the topic. Our objectives were to evaluate human studies addressing dietary intake/nutritional status and the quantity/types of physical activity related to OSA. The search in PubMed, Scopus, and Web of Science databases was conducted to examine relevant articles published from inception to the end of December 2022, utilizing the MeSH strings in the search strategy. Only studies published in English and conducted in humans (≥18 years) without chronic conditions (cancers, kidney/liver disease) or pregnancy were used. Book chapters, abstracts-only, and studies in which participants did not have all three body composition components measured to identify OSA or when body composition components could not be related to the independent/exposure variables were excluded. A total of n = 1020 articles were retrieved from all three databases and eight more from the reference lists. After the exclusion of duplicates and other unsuitable articles, n = 23 studies were evaluated. Among those, eleven were from epidemiological or cross-sectional studies relating nutrients/dietary intake or nutritional status with OSA. Another four examined the relationship between serum biomarkers (vitamin D and ferritin) with OSA, while eight articles presented the results of the interventional studies with resistance training. Overall, higher protein, calcium, potassium, and vitamins D and C intakes emerged as nutrients positively modifying OSA, along with a diet higher in fruits and low-fat dairy foods. Higher serum vitamin D and ferritin were respectively positively and negatively related to OSA. Resistance training was a safe intervention yielding several beneficial outcomes for the OSA syndrome in older women.
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Nutrients
T1  - Nutrition and Physical Activity as Modulators of Osteosarcopenic Adiposity: A Scoping Review and Recommendations for Future Research
IS  - 7
SP  - 1619
VL  - 15
DO  - 10.3390/nu15071619
ER  - 

@article{
author = "Vučić, Vesna M. and Ristić-Medić, Danijela and Arsić, Aleksandra and Petrović, Snježana and Paunović, Marija and Vasiljević, Nađa and Ilich, Jasminka Z.",
year = "2023",
abstract = "Osteosarcopenic adiposity (OSA) syndrome denotes the confluence of bone, muscle, and adipose tissue deterioration. Being a complex entity, numerous uncertainties about OSA still exist, despite the extensive research on the topic. Our objectives were to evaluate human studies addressing dietary intake/nutritional status and the quantity/types of physical activity related to OSA. The search in PubMed, Scopus, and Web of Science databases was conducted to examine relevant articles published from inception to the end of December 2022, utilizing the MeSH strings in the search strategy. Only studies published in English and conducted in humans (≥18 years) without chronic conditions (cancers, kidney/liver disease) or pregnancy were used. Book chapters, abstracts-only, and studies in which participants did not have all three body composition components measured to identify OSA or when body composition components could not be related to the independent/exposure variables were excluded. A total of n = 1020 articles were retrieved from all three databases and eight more from the reference lists. After the exclusion of duplicates and other unsuitable articles, n = 23 studies were evaluated. Among those, eleven were from epidemiological or cross-sectional studies relating nutrients/dietary intake or nutritional status with OSA. Another four examined the relationship between serum biomarkers (vitamin D and ferritin) with OSA, while eight articles presented the results of the interventional studies with resistance training. Overall, higher protein, calcium, potassium, and vitamins D and C intakes emerged as nutrients positively modifying OSA, along with a diet higher in fruits and low-fat dairy foods. Higher serum vitamin D and ferritin were respectively positively and negatively related to OSA. Resistance training was a safe intervention yielding several beneficial outcomes for the OSA syndrome in older women.",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Nutrients",
title = "Nutrition and Physical Activity as Modulators of Osteosarcopenic Adiposity: A Scoping Review and Recommendations for Future Research",
number = "7",
pages = "1619",
volume = "15",
doi = "10.3390/nu15071619"
}

Vučić, V. M., Ristić-Medić, D., Arsić, A., Petrović, S., Paunović, M., Vasiljević, N.,& Ilich, J. Z.. (2023). Nutrition and Physical Activity as Modulators of Osteosarcopenic Adiposity: A Scoping Review and Recommendations for Future Research. in Nutrients
Multidisciplinary Digital Publishing Institute (MDPI)., 15(7), 1619.
https://doi.org/10.3390/nu15071619

Vučić VM, Ristić-Medić D, Arsić A, Petrović S, Paunović M, Vasiljević N, Ilich JZ. Nutrition and Physical Activity as Modulators of Osteosarcopenic Adiposity: A Scoping Review and Recommendations for Future Research. in Nutrients. 2023;15(7):1619.
doi:10.3390/nu15071619 .

Vučić, Vesna M., Ristić-Medić, Danijela, Arsić, Aleksandra, Petrović, Snježana, Paunović, Marija, Vasiljević, Nađa, Ilich, Jasminka Z., "Nutrition and Physical Activity as Modulators of Osteosarcopenic Adiposity: A Scoping Review and Recommendations for Future Research" in Nutrients, 15, no. 7 (2023):1619,
https://doi.org/10.3390/nu15071619 . .

TY  - JOUR
AU  - Paunović, Marija
AU  - Vučić, Vesna
AU  - Milošević, Maja
AU  - Ristić-Medić, Danijela
AU  - Arsić, Aleksandra
AU  - Kojadinović, Milica
AU  - Petrović, Snježana
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1417
AB  - Metabolic syndrome (MetS) is a global public health challenge and one of the main risk factors for cardiovascular diseases. Its pandemic prevalence created a demand for developing a relevant model system for deep insight into the molecular basis of MetS. Animal models, especially Wistar rats, are commonly used for that purpose. However, there are no standardized protocols in terms of the diet, strain, or age of rats used for the development of MetS. Studies have mostly used a high-fat high-fructose (HFHF) diet in Wistar rats but have reported inconsistent results; thus the main aim of this study was to examine the effects of the HFHF diet on inducing MetS in Wistar rats. We used two different sub-strains of Wistar rats – Hannover and Kyoto – of two different age groups (8 weeks and 4 months). Animals were placed on a modified diet, standard chow diet enriched with 25% fat and 20% fructose. Following 8 weeks of treatment, all groups were tested for indicators of MetS and the treatment was extended to 16 weeks for groups that developed some of the required parameters. None of the tested groups developed MetS after 16 weeks of HFHF diet, suggesting that the HFHF diet is not sufficient to develop at least three out of five (visceral obesity, high fasting glucose, high triglyceride, low HDL-cholesterol, high blood pressure) needed parameters. Based on our results, the addition of some pharmacological agents (e.g., cholic acid) is necessary for establishing a rat model system of MetS.
PB  - University of Veterinary and Pharmaceutical Sciences
T2  - Acta Veterinaria Brno
T1  - Use of high-fat high-fructose diet for a model of metabolic syndrome in Wistar rats: challenges remain
EP  - 396
IS  - 4
SP  - 389
VL  - 92
DO  - 10.2754/avb202392040389
ER  - 

@article{
author = "Paunović, Marija and Vučić, Vesna and Milošević, Maja and Ristić-Medić, Danijela and Arsić, Aleksandra and Kojadinović, Milica and Petrović, Snježana",
year = "2023",
abstract = "Metabolic syndrome (MetS) is a global public health challenge and one of the main risk factors for cardiovascular diseases. Its pandemic prevalence created a demand for developing a relevant model system for deep insight into the molecular basis of MetS. Animal models, especially Wistar rats, are commonly used for that purpose. However, there are no standardized protocols in terms of the diet, strain, or age of rats used for the development of MetS. Studies have mostly used a high-fat high-fructose (HFHF) diet in Wistar rats but have reported inconsistent results; thus the main aim of this study was to examine the effects of the HFHF diet on inducing MetS in Wistar rats. We used two different sub-strains of Wistar rats – Hannover and Kyoto – of two different age groups (8 weeks and 4 months). Animals were placed on a modified diet, standard chow diet enriched with 25% fat and 20% fructose. Following 8 weeks of treatment, all groups were tested for indicators of MetS and the treatment was extended to 16 weeks for groups that developed some of the required parameters. None of the tested groups developed MetS after 16 weeks of HFHF diet, suggesting that the HFHF diet is not sufficient to develop at least three out of five (visceral obesity, high fasting glucose, high triglyceride, low HDL-cholesterol, high blood pressure) needed parameters. Based on our results, the addition of some pharmacological agents (e.g., cholic acid) is necessary for establishing a rat model system of MetS.",
publisher = "University of Veterinary and Pharmaceutical Sciences",
journal = "Acta Veterinaria Brno",
title = "Use of high-fat high-fructose diet for a model of metabolic syndrome in Wistar rats: challenges remain",
pages = "396-389",
number = "4",
volume = "92",
doi = "10.2754/avb202392040389"
}

Paunović, M., Vučić, V., Milošević, M., Ristić-Medić, D., Arsić, A., Kojadinović, M.,& Petrović, S.. (2023). Use of high-fat high-fructose diet for a model of metabolic syndrome in Wistar rats: challenges remain. in Acta Veterinaria Brno
University of Veterinary and Pharmaceutical Sciences., 92(4), 389-396.
https://doi.org/10.2754/avb202392040389

Paunović M, Vučić V, Milošević M, Ristić-Medić D, Arsić A, Kojadinović M, Petrović S. Use of high-fat high-fructose diet for a model of metabolic syndrome in Wistar rats: challenges remain. in Acta Veterinaria Brno. 2023;92(4):389-396.
doi:10.2754/avb202392040389 .

Paunović, Marija, Vučić, Vesna, Milošević, Maja, Ristić-Medić, Danijela, Arsić, Aleksandra, Kojadinović, Milica, Petrović, Snježana, "Use of high-fat high-fructose diet for a model of metabolic syndrome in Wistar rats: challenges remain" in Acta Veterinaria Brno, 92, no. 4 (2023):389-396,
https://doi.org/10.2754/avb202392040389 . .

TY  - JOUR
AU  - Arsić, Aleksandra
AU  - Krstić, Predrag
AU  - Paunović, Marija
AU  - Nedović, Jasmina
AU  - Jakovljević, Vladimir
AU  - Vučić, Vesna
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1313
AB  - Breast cancer is the most common malignant tumor and one of the leading causes of cancer-related death in women throughout the world. This study is a parallel, randomized, double-blind, controlled, 12-week supplementation trial, investigating the anti-inflammatory effects of dietary intake of fish oil and evening primrose oil (EPO), in patients with breast cancer undergoing chemotherapy. The primary outcomes were changes in the nutritional status and inflammatory cytokines of patients during the study. The secondary outcomes were changes in hematological and biochemical parameters and fatty acid profile. Of the 32 eligible patients, half of them is randomly assigned to a treatment arm with fish oil and EPO (n = 16), or a control arm (n = 16) with mineral oil as a placebo. The intervention group was taking 2 gel capsules of fish oil and 3 gel capsules of EPO (400 mg eicosapentaenoic acid, 600 mg docosahexaenoic acid, and 351 mg gamma-linolenic acid) fish oil and evening primrose oil for 12 weeks, during their chemotherapy. The control/placebo group was taking 5 gel capsules of 1g of mineral oil. One of the patients dropped out due to discontinuation of the treatment (in the placebo group) and two did not show up at the post-treatment measurements (in the intervention group), thus, 29 women completed the study. The results showed an increase in plasma levels of docosapentaenoic acid (22:5n-3), docosahexaenoic acid (22:6n-3), total n-3PUFA, vaccenic acid (18:1n-7), and a decrease in n-6/n-3 PUFA ratio in the intervention group. An increase in the plasma level of dihomo-gamma-linolenic acid (20:3n-6) was observed in the placebo group. There was no difference in plasma levels of interleukin (IL) IL-8, IL-10, and tumor necrosis factor-alpha, while the level of IL-6 decreased in both groups and was significantly lower in the intervention group at the end of the study. In conclusion, this supplementation improved the PUFA status and decreased the level of IL-6 in breast cancer patients undergoing chemotherapy. Consequently, this treatment may help reduce cancer complications resulting from impaired lipid metabolism and inflammation. ClinicalTrials.gov Identifier: NCT03516253. Date of registration 04/05/2018.
PB  - Springer Nature
T2  - Scientific Reports
T1  - Anti-inflammatory effect of combining fish oil and evening primrose oil supplementation on breast cancer patients undergoing chemotherapy: a randomized placebo-controlled trial
IS  - 1
SP  - 6449
VL  - 13
DO  - 10.1038/s41598-023-28411-8
ER  - 

@article{
author = "Arsić, Aleksandra and Krstić, Predrag and Paunović, Marija and Nedović, Jasmina and Jakovljević, Vladimir and Vučić, Vesna",
year = "2023",
abstract = "Breast cancer is the most common malignant tumor and one of the leading causes of cancer-related death in women throughout the world. This study is a parallel, randomized, double-blind, controlled, 12-week supplementation trial, investigating the anti-inflammatory effects of dietary intake of fish oil and evening primrose oil (EPO), in patients with breast cancer undergoing chemotherapy. The primary outcomes were changes in the nutritional status and inflammatory cytokines of patients during the study. The secondary outcomes were changes in hematological and biochemical parameters and fatty acid profile. Of the 32 eligible patients, half of them is randomly assigned to a treatment arm with fish oil and EPO (n = 16), or a control arm (n = 16) with mineral oil as a placebo. The intervention group was taking 2 gel capsules of fish oil and 3 gel capsules of EPO (400 mg eicosapentaenoic acid, 600 mg docosahexaenoic acid, and 351 mg gamma-linolenic acid) fish oil and evening primrose oil for 12 weeks, during their chemotherapy. The control/placebo group was taking 5 gel capsules of 1g of mineral oil. One of the patients dropped out due to discontinuation of the treatment (in the placebo group) and two did not show up at the post-treatment measurements (in the intervention group), thus, 29 women completed the study. The results showed an increase in plasma levels of docosapentaenoic acid (22:5n-3), docosahexaenoic acid (22:6n-3), total n-3PUFA, vaccenic acid (18:1n-7), and a decrease in n-6/n-3 PUFA ratio in the intervention group. An increase in the plasma level of dihomo-gamma-linolenic acid (20:3n-6) was observed in the placebo group. There was no difference in plasma levels of interleukin (IL) IL-8, IL-10, and tumor necrosis factor-alpha, while the level of IL-6 decreased in both groups and was significantly lower in the intervention group at the end of the study. In conclusion, this supplementation improved the PUFA status and decreased the level of IL-6 in breast cancer patients undergoing chemotherapy. Consequently, this treatment may help reduce cancer complications resulting from impaired lipid metabolism and inflammation. ClinicalTrials.gov Identifier: NCT03516253. Date of registration 04/05/2018.",
publisher = "Springer Nature",
journal = "Scientific Reports",
title = "Anti-inflammatory effect of combining fish oil and evening primrose oil supplementation on breast cancer patients undergoing chemotherapy: a randomized placebo-controlled trial",
number = "1",
pages = "6449",
volume = "13",
doi = "10.1038/s41598-023-28411-8"
}

Arsić, A., Krstić, P., Paunović, M., Nedović, J., Jakovljević, V.,& Vučić, V.. (2023). Anti-inflammatory effect of combining fish oil and evening primrose oil supplementation on breast cancer patients undergoing chemotherapy: a randomized placebo-controlled trial. in Scientific Reports
Springer Nature., 13(1), 6449.
https://doi.org/10.1038/s41598-023-28411-8

Arsić A, Krstić P, Paunović M, Nedović J, Jakovljević V, Vučić V. Anti-inflammatory effect of combining fish oil and evening primrose oil supplementation on breast cancer patients undergoing chemotherapy: a randomized placebo-controlled trial. in Scientific Reports. 2023;13(1):6449.
doi:10.1038/s41598-023-28411-8 .

Arsić, Aleksandra, Krstić, Predrag, Paunović, Marija, Nedović, Jasmina, Jakovljević, Vladimir, Vučić, Vesna, "Anti-inflammatory effect of combining fish oil and evening primrose oil supplementation on breast cancer patients undergoing chemotherapy: a randomized placebo-controlled trial" in Scientific Reports, 13, no. 1 (2023):6449,
https://doi.org/10.1038/s41598-023-28411-8 . .

TY  - JOUR
AU  - Zelenović, Nevena
AU  - Kojadinović, Milica
AU  - Filipović, Lidija
AU  - Vučić, Vesna
AU  - Milčić, Miloš
AU  - Arsić, Aleksandra
AU  - Popović, Milica
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1309
AB  - Backgound/Objectives: Urolithins (UROs) are the metabolites derived from the gut microbial action on ellagitannins and ellagic acid-rich foods. Following their absorption in the intestine, UROs are transported through the systemic circulation to various tissues where they can express their biological function as antimicrobial, anti-inflammatory, and anticancer agents. In addition to blood plasma, where they can be found as glucuronide and sulfate conjugates, they are also found in urine. Therefore, the interactions of UROs with serum proteins are of great clinical interest. Methods: A powerful technique for examining these urolithin-serum protein interactions is fluorescence spectroscopy. Bovine serum albumin (BSA) is a particularly suitable model protein because it is readily available, affordable, and similar to human serum albumin. This work aimed to study the binding of UROs (urolithin A, UROA and urolithin B, UROB) and their glucuronide conjugates (UROAG and UROBG) to BSA by quenching the intrinsic fluorescence of protein. Results: The spectra obtained showed that the binding process is influenced by the polyphenol's structure and the conjugation process with the glucuronide. The calculated Stern Vollmer binding constants (Ksv): UROA and UROB Ksv were 59236 ± 5706 and 69653 ± 14922, respectively, while for UROAG and UROBG, these values were 15179 ± 2770 and 9462 ± 1955, respectively, which showed that the binding affinity decreased with glucuronidation. Molecular docking studies confirmed that all of the studied molecules will bind favorably to BSA. The preferential binding site for both UROs and UROGs is Sudlow I, while UROs will also bind to Sudlow II. URO-Gs can bind to BSA in the cleft region with lower binding scores than for the Sudlow I binding site. Conclusion: The aglycone's higher hydrophobicity increases the binding affinity to BSA, thus reducing its bioavailability in the blood.
PB  - SAGE
T2  - Natural Product Communications
T1  - Interactions of Different Urolithins With Bovine Serum Albumin
IS  - 5
VL  - 18
DO  - 10.1177/1934578X231169366
ER  - 

@article{
author = "Zelenović, Nevena and Kojadinović, Milica and Filipović, Lidija and Vučić, Vesna and Milčić, Miloš and Arsić, Aleksandra and Popović, Milica",
year = "2023",
abstract = "Backgound/Objectives: Urolithins (UROs) are the metabolites derived from the gut microbial action on ellagitannins and ellagic acid-rich foods. Following their absorption in the intestine, UROs are transported through the systemic circulation to various tissues where they can express their biological function as antimicrobial, anti-inflammatory, and anticancer agents. In addition to blood plasma, where they can be found as glucuronide and sulfate conjugates, they are also found in urine. Therefore, the interactions of UROs with serum proteins are of great clinical interest. Methods: A powerful technique for examining these urolithin-serum protein interactions is fluorescence spectroscopy. Bovine serum albumin (BSA) is a particularly suitable model protein because it is readily available, affordable, and similar to human serum albumin. This work aimed to study the binding of UROs (urolithin A, UROA and urolithin B, UROB) and their glucuronide conjugates (UROAG and UROBG) to BSA by quenching the intrinsic fluorescence of protein. Results: The spectra obtained showed that the binding process is influenced by the polyphenol's structure and the conjugation process with the glucuronide. The calculated Stern Vollmer binding constants (Ksv): UROA and UROB Ksv were 59236 ± 5706 and 69653 ± 14922, respectively, while for UROAG and UROBG, these values were 15179 ± 2770 and 9462 ± 1955, respectively, which showed that the binding affinity decreased with glucuronidation. Molecular docking studies confirmed that all of the studied molecules will bind favorably to BSA. The preferential binding site for both UROs and UROGs is Sudlow I, while UROs will also bind to Sudlow II. URO-Gs can bind to BSA in the cleft region with lower binding scores than for the Sudlow I binding site. Conclusion: The aglycone's higher hydrophobicity increases the binding affinity to BSA, thus reducing its bioavailability in the blood.",
publisher = "SAGE",
journal = "Natural Product Communications",
title = "Interactions of Different Urolithins With Bovine Serum Albumin",
number = "5",
volume = "18",
doi = "10.1177/1934578X231169366"
}

Zelenović, N., Kojadinović, M., Filipović, L., Vučić, V., Milčić, M., Arsić, A.,& Popović, M.. (2023). Interactions of Different Urolithins With Bovine Serum Albumin. in Natural Product Communications
SAGE., 18(5).
https://doi.org/10.1177/1934578X231169366

Zelenović N, Kojadinović M, Filipović L, Vučić V, Milčić M, Arsić A, Popović M. Interactions of Different Urolithins With Bovine Serum Albumin. in Natural Product Communications. 2023;18(5).
doi:10.1177/1934578X231169366 .

Zelenović, Nevena, Kojadinović, Milica, Filipović, Lidija, Vučić, Vesna, Milčić, Miloš, Arsić, Aleksandra, Popović, Milica, "Interactions of Different Urolithins With Bovine Serum Albumin" in Natural Product Communications, 18, no. 5 (2023),
https://doi.org/10.1177/1934578X231169366 . .

TY  - JOUR
AU  - Bajerska, Joanna
AU  - Skoczek-Rubińska, Aleksandra
AU  - Małczak, Lidia
AU  - Vučić, Vesna
AU  - Arsić, Aleksandra
AU  - Kojadinović, Milica
AU  - Ristić-Medić, Danijela
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1310
AB  - It is hypothesized that plasma proportion of selected fatty acids (FAs) and dietary habits are linked with the risk of cardiovascular disease (CVD) in postmenopausal women. Therefore, this study was designed to determine the association of plasma FA composition and markers of dietary habits with an atherogenic index of plasma (AIP), a predictor of CVD risk in postmenopausal women. In total, 87 postmenopausal women with an average age of 57 ± 7 years were recruited and their dietary intake, anthropometric and biochemical parameters, and FA status in total plasma lipid proportions were determined, showing that 65.5% of the participants had a high risk of CVD according to their AIP value. After adjusting for some confounders (age, body mass index, and physical activity level), the risk of CVD was only positively associated with the frequency of consumption of animal fat spreads (butter and lard) of terrestrial origin. Regarding the FA profile, CVD risk was positively associated with the percentages of vaccenic acid, dihomo-γ-linolenic acid, and monounsaturated fatty acids (MUFA; mainly n-7) in total FA, as well as the MUFA/SFA ratio in total plasma and stearoyl-CoA desaturase-16 activity (16:1/16:0 ratio). In contrast, the risk of CVD was negatively associated with percentages of α-linolenic acid, total polyunsaturated fatty acids (PUFA), and PUFA/MUFA ratio in total plasma lipid, and the estimated activity of Δ5-desaturase (20:4/20:3 n-6 ratio). These results support the current recommendations to decrease the frequency of animal fat spread intake because it is associated with a reduced CVD risk based on AIP in postmenopausal women. In accordance with these plasma percentages of ALA, vaccenic acid, dihomo-γ-linolenic acid, PUFA, PUFA/MUFA ratio, and 16:1/16:0 ratio may be important parameters in CVD risk assessment.
PB  - Elsevier
T2  - Nutrition Research
T2  - Nutrition ResearchNutrition Research
T1  - Plasma fatty acid composition and some markers of dietary habits are associated with cardiovascular disease risk determined by an atherogenic plasma index in postmenopausal women
EP  - 60
SP  - 47
VL  - 115
DO  - 10.1016/j.nutres.2023.05.008
ER  - 

@article{
author = "Bajerska, Joanna and Skoczek-Rubińska, Aleksandra and Małczak, Lidia and Vučić, Vesna and Arsić, Aleksandra and Kojadinović, Milica and Ristić-Medić, Danijela",
year = "2023",
abstract = "It is hypothesized that plasma proportion of selected fatty acids (FAs) and dietary habits are linked with the risk of cardiovascular disease (CVD) in postmenopausal women. Therefore, this study was designed to determine the association of plasma FA composition and markers of dietary habits with an atherogenic index of plasma (AIP), a predictor of CVD risk in postmenopausal women. In total, 87 postmenopausal women with an average age of 57 ± 7 years were recruited and their dietary intake, anthropometric and biochemical parameters, and FA status in total plasma lipid proportions were determined, showing that 65.5% of the participants had a high risk of CVD according to their AIP value. After adjusting for some confounders (age, body mass index, and physical activity level), the risk of CVD was only positively associated with the frequency of consumption of animal fat spreads (butter and lard) of terrestrial origin. Regarding the FA profile, CVD risk was positively associated with the percentages of vaccenic acid, dihomo-γ-linolenic acid, and monounsaturated fatty acids (MUFA; mainly n-7) in total FA, as well as the MUFA/SFA ratio in total plasma and stearoyl-CoA desaturase-16 activity (16:1/16:0 ratio). In contrast, the risk of CVD was negatively associated with percentages of α-linolenic acid, total polyunsaturated fatty acids (PUFA), and PUFA/MUFA ratio in total plasma lipid, and the estimated activity of Δ5-desaturase (20:4/20:3 n-6 ratio). These results support the current recommendations to decrease the frequency of animal fat spread intake because it is associated with a reduced CVD risk based on AIP in postmenopausal women. In accordance with these plasma percentages of ALA, vaccenic acid, dihomo-γ-linolenic acid, PUFA, PUFA/MUFA ratio, and 16:1/16:0 ratio may be important parameters in CVD risk assessment.",
publisher = "Elsevier",
journal = "Nutrition Research, Nutrition ResearchNutrition Research",
title = "Plasma fatty acid composition and some markers of dietary habits are associated with cardiovascular disease risk determined by an atherogenic plasma index in postmenopausal women",
pages = "60-47",
volume = "115",
doi = "10.1016/j.nutres.2023.05.008"
}

Bajerska, J., Skoczek-Rubińska, A., Małczak, L., Vučić, V., Arsić, A., Kojadinović, M.,& Ristić-Medić, D.. (2023). Plasma fatty acid composition and some markers of dietary habits are associated with cardiovascular disease risk determined by an atherogenic plasma index in postmenopausal women. in Nutrition Research
Elsevier., 115, 47-60.
https://doi.org/10.1016/j.nutres.2023.05.008

Bajerska J, Skoczek-Rubińska A, Małczak L, Vučić V, Arsić A, Kojadinović M, Ristić-Medić D. Plasma fatty acid composition and some markers of dietary habits are associated with cardiovascular disease risk determined by an atherogenic plasma index in postmenopausal women. in Nutrition Research. 2023;115:47-60.
doi:10.1016/j.nutres.2023.05.008 .

Bajerska, Joanna, Skoczek-Rubińska, Aleksandra, Małczak, Lidia, Vučić, Vesna, Arsić, Aleksandra, Kojadinović, Milica, Ristić-Medić, Danijela, "Plasma fatty acid composition and some markers of dietary habits are associated with cardiovascular disease risk determined by an atherogenic plasma index in postmenopausal women" in Nutrition Research, 115 (2023):47-60,
https://doi.org/10.1016/j.nutres.2023.05.008 . .

TY  - JOUR
AU  - Rajković, Katarina M.
AU  - Drobac, Milica
AU  - Milić, Petar
AU  - Vučić, Vesna
AU  - Arsić, Aleksandra
AU  - Perić, Mirijana
AU  - Radunović, Milena
AU  - Jeremić, Sanja
AU  - Arsenijević, Jelena
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1322
AB  - Juglans nigra (Black walnut) is a source of health-supporting biologically active compounds used in traditional medicine. The investigation of bioactive compounds in black walnut could lead to its broader application, as well as to the application of its by-products. Therefore, this study aimed to characterize J. nigra nut and green husk based on chemical analysis of their petroleum ether and ethanol extracts obtained by ultrasonic and reflux extraction methods, respectively. Different extract fractions were tested for their antimicrobial activities using Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa), Gram-positive bacteria (Enterococcus faecalis, Staphylococcus aureus) and yeast (reference strain and clinical isolates of Candida albicans). The ethanol extracts analysis, performed by high performance liquid chromatography, singled out the ellagic acid as the most dominant compound in nut ((55.0±1.3)×10-3 kg m-3) and green husk ((114.1±0.5)×10-3 kg m-3) extracts. Non-polar compounds were evaluated using gas chromatography analysis of petroleum ether extracts. Juglans nigra nut and green husk contained two saturated fatty acids, palmitic acid (C16:0) and stearic acid (C18:0), then, monounsaturated fatty acids, palmitoleic (C16:1n-7), oleic (C18:1n-9) and vaccenic acid (C18:1n-7), as well as polyunsaturated fatty acids, linoleic (C18:2n- -6), γ-linolenic (C18:3n-6) and α-linolenic (C18:3n-3) acids. Ethanol extracts of both J. nigra nut and green husk showed antimicrobial activity against C. albicans, which is the most common cause of yeast infections.
PB  - Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Chemical characterization and antimicrobial activity of Juglans nigra L. nut and green husk
EP  - 614
IS  - 6
SP  - 603
VL  - 88
DO  - 10.2298/JSC230210024R
ER  - 

@article{
author = "Rajković, Katarina M. and Drobac, Milica and Milić, Petar and Vučić, Vesna and Arsić, Aleksandra and Perić, Mirijana and Radunović, Milena and Jeremić, Sanja and Arsenijević, Jelena",
year = "2023",
abstract = "Juglans nigra (Black walnut) is a source of health-supporting biologically active compounds used in traditional medicine. The investigation of bioactive compounds in black walnut could lead to its broader application, as well as to the application of its by-products. Therefore, this study aimed to characterize J. nigra nut and green husk based on chemical analysis of their petroleum ether and ethanol extracts obtained by ultrasonic and reflux extraction methods, respectively. Different extract fractions were tested for their antimicrobial activities using Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa), Gram-positive bacteria (Enterococcus faecalis, Staphylococcus aureus) and yeast (reference strain and clinical isolates of Candida albicans). The ethanol extracts analysis, performed by high performance liquid chromatography, singled out the ellagic acid as the most dominant compound in nut ((55.0±1.3)×10-3 kg m-3) and green husk ((114.1±0.5)×10-3 kg m-3) extracts. Non-polar compounds were evaluated using gas chromatography analysis of petroleum ether extracts. Juglans nigra nut and green husk contained two saturated fatty acids, palmitic acid (C16:0) and stearic acid (C18:0), then, monounsaturated fatty acids, palmitoleic (C16:1n-7), oleic (C18:1n-9) and vaccenic acid (C18:1n-7), as well as polyunsaturated fatty acids, linoleic (C18:2n- -6), γ-linolenic (C18:3n-6) and α-linolenic (C18:3n-3) acids. Ethanol extracts of both J. nigra nut and green husk showed antimicrobial activity against C. albicans, which is the most common cause of yeast infections.",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society, Journal of the Serbian Chemical Society",
title = "Chemical characterization and antimicrobial activity of Juglans nigra L. nut and green husk",
pages = "614-603",
number = "6",
volume = "88",
doi = "10.2298/JSC230210024R"
}

Rajković, K. M., Drobac, M., Milić, P., Vučić, V., Arsić, A., Perić, M., Radunović, M., Jeremić, S.,& Arsenijević, J.. (2023). Chemical characterization and antimicrobial activity of Juglans nigra L. nut and green husk. in Journal of the Serbian Chemical Society
Serbian Chemical Society., 88(6), 603-614.
https://doi.org/10.2298/JSC230210024R

Rajković KM, Drobac M, Milić P, Vučić V, Arsić A, Perić M, Radunović M, Jeremić S, Arsenijević J. Chemical characterization and antimicrobial activity of Juglans nigra L. nut and green husk. in Journal of the Serbian Chemical Society. 2023;88(6):603-614.
doi:10.2298/JSC230210024R .

Rajković, Katarina M., Drobac, Milica, Milić, Petar, Vučić, Vesna, Arsić, Aleksandra, Perić, Mirijana, Radunović, Milena, Jeremić, Sanja, Arsenijević, Jelena, "Chemical characterization and antimicrobial activity of Juglans nigra L. nut and green husk" in Journal of the Serbian Chemical Society, 88, no. 6 (2023):603-614,
https://doi.org/10.2298/JSC230210024R . .

TY  - JOUR
AU  - Minić, Rajna
AU  - Arsić, Aleksandra
AU  - Kojadinović, Milica
AU  - Palibrk, Aleksa
AU  - Đorđević, Brizita
AU  - Stević, Zorica
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1397
AB  - Background: Recent literature data highlights metabolic changes in amyotrophic lateral sclerosis (ALS). To explore possible early metabolic changes, we aimed to analyse the fatty acids (FA) composition of erythrocytes in newly diagnosed als patients and to see whether fatty acid levels correlate with the ALSFRS-R score or disease duration. Methods: The severity of motor function involvement was assessed by the ALSFRS-R scale at the initial evaluation. The fatty acid profile of erythrocyte membranes was analysed by gas-liquid chromatography. The study comprised 26 clinically diagnosed als patients, with mean ALSFRS-R 38±8. The control group included 26 healthy volunteers. Results: Significantly higher levels of palmitic acid and total saturated FAs were detected in als patients. In als patients, total monounsaturated FA, palmitoleic, vaccenic, and oleic acid were also significantly increased. The levels of eicosapentaenoic acid, docosapentaenoic acid, total polyunsaturated FA (PUFA) and n-6 PUFA were significantly lower in als patients. Additionally, a-linolenic acid, the precursor of the n-3 PUFA family, was not detected in als patients. We found no significant correlation between the ALSFRS-R score and the abundance of individual FAs analysed. A moderate negative correlation was found between disease duration and DHA level, and a positive correlation was detected with MUFA. Conclusion: Experimental evidence presented may contribute to shaping a beneficial nutritional intervention.
PB  - Society of Medical Biochemists of Serbia
T2  - Journal of Medical Biochemistry
T1  - Erythrocyte fatty acid aberrations in Amyotrophic Lateral Sclerosis: Correlation with disease duration
EP  - 629
IS  - 4
SP  - 621
VL  - 42
DO  - 10.5937/jomb0-40387
ER  - 

@article{
author = "Minić, Rajna and Arsić, Aleksandra and Kojadinović, Milica and Palibrk, Aleksa and Đorđević, Brizita and Stević, Zorica",
year = "2023",
abstract = "Background: Recent literature data highlights metabolic changes in amyotrophic lateral sclerosis (ALS). To explore possible early metabolic changes, we aimed to analyse the fatty acids (FA) composition of erythrocytes in newly diagnosed als patients and to see whether fatty acid levels correlate with the ALSFRS-R score or disease duration. Methods: The severity of motor function involvement was assessed by the ALSFRS-R scale at the initial evaluation. The fatty acid profile of erythrocyte membranes was analysed by gas-liquid chromatography. The study comprised 26 clinically diagnosed als patients, with mean ALSFRS-R 38±8. The control group included 26 healthy volunteers. Results: Significantly higher levels of palmitic acid and total saturated FAs were detected in als patients. In als patients, total monounsaturated FA, palmitoleic, vaccenic, and oleic acid were also significantly increased. The levels of eicosapentaenoic acid, docosapentaenoic acid, total polyunsaturated FA (PUFA) and n-6 PUFA were significantly lower in als patients. Additionally, a-linolenic acid, the precursor of the n-3 PUFA family, was not detected in als patients. We found no significant correlation between the ALSFRS-R score and the abundance of individual FAs analysed. A moderate negative correlation was found between disease duration and DHA level, and a positive correlation was detected with MUFA. Conclusion: Experimental evidence presented may contribute to shaping a beneficial nutritional intervention.",
publisher = "Society of Medical Biochemists of Serbia",
journal = "Journal of Medical Biochemistry",
title = "Erythrocyte fatty acid aberrations in Amyotrophic Lateral Sclerosis: Correlation with disease duration",
pages = "629-621",
number = "4",
volume = "42",
doi = "10.5937/jomb0-40387"
}

Minić, R., Arsić, A., Kojadinović, M., Palibrk, A., Đorđević, B.,& Stević, Z.. (2023). Erythrocyte fatty acid aberrations in Amyotrophic Lateral Sclerosis: Correlation with disease duration. in Journal of Medical Biochemistry
Society of Medical Biochemists of Serbia., 42(4), 621-629.
https://doi.org/10.5937/jomb0-40387

Minić R, Arsić A, Kojadinović M, Palibrk A, Đorđević B, Stević Z. Erythrocyte fatty acid aberrations in Amyotrophic Lateral Sclerosis: Correlation with disease duration. in Journal of Medical Biochemistry. 2023;42(4):621-629.
doi:10.5937/jomb0-40387 .

Minić, Rajna, Arsić, Aleksandra, Kojadinović, Milica, Palibrk, Aleksa, Đorđević, Brizita, Stević, Zorica, "Erythrocyte fatty acid aberrations in Amyotrophic Lateral Sclerosis: Correlation with disease duration" in Journal of Medical Biochemistry, 42, no. 4 (2023):621-629,
https://doi.org/10.5937/jomb0-40387 . .

TY  - JOUR
AU  - Ristić-Medić, Danijela
AU  - Petrović, Snježana
AU  - Polak, Tomaž
AU  - Bertoncelj, Jasna
AU  - Arsić, Aleksandra
AU  - Takić, Marija
AU  - Vučić, Vesna M.
AU  - Gurinović, Mirjana
AU  - Korošec, Mojca
PY  - 2022
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1232
AB  - Objectives: Industrially produced trans fatty acid (iTFA) have adverse health effects and thus their consumption should be limited. The aim of this study was to determine and compare the iTFA content in frequently consumed food products by young adults from the Serbian and Slovenian market with supposedly elevated iTFA content in 2015. At the time of this study, there was no recommended limit of iTFA in both countries, and reduction of iTFA in foods was on voluntary basis.Methods: We determined iTFA content in food products, 19 from the Serbian and 22 from the Slovenian market, blinded and analysed in the same analytical run. Contents of fatty acids (FA) methyl esters were analysed by capillary gas chromatography with a flame ionisation detector. Heptadecanoic acid was used as internal standard. Individual FA along with TFA were expressed as percentages of total measured FA. The amount of each FA in the sample was then calculated from the response factor and the transformation factor of the FA from the FA methyl ester content.Results: Elaidic acid (C18:1t) was found as the most abundant TFA in analysed products, ranging from 0.52 g/100 g of total FA in chocolate candy up to 60.4 g/100 g in a salami from Serbian market. In Slovenian products, the values for elaidic acid were lower, 0.04-3.95 g/100 g of total FA, except in one type of wafers (24.3 g/100 g).Conclusions: The majority of analysed products from the Serbian and three from Slovenian market exceeded the recommended WHO and EU limit of 2% iTFA of total fat in foods. Samples of frequently consumed salami, wafers, tea biscuits, and snacks were identified as products with potentially higher burden of iTFA in diets of young adults in Serbia.
T2  - Central European Journal of Public Health
T2  - Central European Journal of Public Health
T1  - Trans fatty acids in frequently consumed products from Serbian and Slovenian market
EP  - 57
IS  - 1
SP  - 51
VL  - 30
DO  - 10.21101/cejph.a5928
DO  - 10.21101/cejph.a5928
ER  - 

@article{
author = "Ristić-Medić, Danijela and Petrović, Snježana and Polak, Tomaž and Bertoncelj, Jasna and Arsić, Aleksandra and Takić, Marija and Vučić, Vesna M. and Gurinović, Mirjana and Korošec, Mojca",
year = "2022",
abstract = "Objectives: Industrially produced trans fatty acid (iTFA) have adverse health effects and thus their consumption should be limited. The aim of this study was to determine and compare the iTFA content in frequently consumed food products by young adults from the Serbian and Slovenian market with supposedly elevated iTFA content in 2015. At the time of this study, there was no recommended limit of iTFA in both countries, and reduction of iTFA in foods was on voluntary basis.Methods: We determined iTFA content in food products, 19 from the Serbian and 22 from the Slovenian market, blinded and analysed in the same analytical run. Contents of fatty acids (FA) methyl esters were analysed by capillary gas chromatography with a flame ionisation detector. Heptadecanoic acid was used as internal standard. Individual FA along with TFA were expressed as percentages of total measured FA. The amount of each FA in the sample was then calculated from the response factor and the transformation factor of the FA from the FA methyl ester content.Results: Elaidic acid (C18:1t) was found as the most abundant TFA in analysed products, ranging from 0.52 g/100 g of total FA in chocolate candy up to 60.4 g/100 g in a salami from Serbian market. In Slovenian products, the values for elaidic acid were lower, 0.04-3.95 g/100 g of total FA, except in one type of wafers (24.3 g/100 g).Conclusions: The majority of analysed products from the Serbian and three from Slovenian market exceeded the recommended WHO and EU limit of 2% iTFA of total fat in foods. Samples of frequently consumed salami, wafers, tea biscuits, and snacks were identified as products with potentially higher burden of iTFA in diets of young adults in Serbia.",
journal = "Central European Journal of Public Health, Central European Journal of Public Health",
title = "Trans fatty acids in frequently consumed products from Serbian and Slovenian market",
pages = "57-51",
number = "1",
volume = "30",
doi = "10.21101/cejph.a5928, 10.21101/cejph.a5928"
}

Ristić-Medić, D., Petrović, S., Polak, T., Bertoncelj, J., Arsić, A., Takić, M., Vučić, V. M., Gurinović, M.,& Korošec, M.. (2022). Trans fatty acids in frequently consumed products from Serbian and Slovenian market. in Central European Journal of Public Health, 30(1), 51-57.
https://doi.org/10.21101/cejph.a5928

Ristić-Medić D, Petrović S, Polak T, Bertoncelj J, Arsić A, Takić M, Vučić VM, Gurinović M, Korošec M. Trans fatty acids in frequently consumed products from Serbian and Slovenian market. in Central European Journal of Public Health. 2022;30(1):51-57.
doi:10.21101/cejph.a5928 .

Ristić-Medić, Danijela, Petrović, Snježana, Polak, Tomaž, Bertoncelj, Jasna, Arsić, Aleksandra, Takić, Marija, Vučić, Vesna M., Gurinović, Mirjana, Korošec, Mojca, "Trans fatty acids in frequently consumed products from Serbian and Slovenian market" in Central European Journal of Public Health, 30, no. 1 (2022):51-57,
https://doi.org/10.21101/cejph.a5928 . .

TY  - JOUR
AU  - Ristić-Medić, Danijela
AU  - Petrović, Snježana
AU  - Takić, Marija
AU  - Vučić, Vesna
AU  - Arsić, Aleksandra
AU  - Rađen, Slavica
AU  - Glibetić, Marija
PY  - 2022
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1338
AB  - Polyunsaturated fatty acid (PUFA) dietary intake, status and serum key fatty acid
(FA) ratios may aid in cardiovascular disease-related risk assessment. The aim of this study was to investigate
the effects of lipid-lowering diet on key FA ratios in serum phospholipids and omega-3 index in
erythrocyte phospholipids in moderately hyperlipidemic subjects. The study included 41 subjects, mean
age 56±6 years. Nutritional habits were evaluated by food frequency questionnaire. Participants followed
lipid lowering diet for 12 weeks. Energy intake of omega-6 and omega-3 FA was changed from 7.6%
and 0.6% to 5.7% and 1.2%, respectively. Marked decrease in four FA ratios in serum phospholipids,
i.e., omega-6/omega-3, arachidonic acid (AA)/eicosapentaenoic acid (EPA), AA/docosahexaenoic acid
(DHA), AA/(EPA+DHA) and omega-3 index (EPA+DHA) was found in study subjects after lipid-
lowering diet. Total cholesterol/high-density lipoprotein (HDL), low-density lipoprotein (LDL)/
HDL and triacylglycerol/HDL-cholesterol ratios positively correlated with all FA ratios, and negatively
correlated with total omega-3 levels in serum phospholipids and omega-3 index in erythrocytes. Total
serum omega-3 levels showed strongest association with lipoprotein ratios and positive correlation with
homeostatic model assessment (HOMA) index. In conclusion, lipid-lowering diet resulted in decreased
serum key FA ratios, increased omega-3 levels, and improved insulin sensitivity that may lead to a lower
risk of cardiovascular disease in subjects with moderate hyperlipidemia.
PB  - Klinicka bolnica Sestre Milosrdnice
T2  - Acta clinica Croatica
T1  - Efficacy of a Lipid-Lowering Diet on Key Fatty Acid Ratios and Omega-3 Index in Hyperlipidemic Subjects
EP  - 226
IS  - 2
SP  - 220
VL  - 61
DO  - 10.20471/acc.2022.61.02.08
ER  - 

@article{
author = "Ristić-Medić, Danijela and Petrović, Snježana and Takić, Marija and Vučić, Vesna and Arsić, Aleksandra and Rađen, Slavica and Glibetić, Marija",
year = "2022",
abstract = "Polyunsaturated fatty acid (PUFA) dietary intake, status and serum key fatty acid
(FA) ratios may aid in cardiovascular disease-related risk assessment. The aim of this study was to investigate
the effects of lipid-lowering diet on key FA ratios in serum phospholipids and omega-3 index in
erythrocyte phospholipids in moderately hyperlipidemic subjects. The study included 41 subjects, mean
age 56±6 years. Nutritional habits were evaluated by food frequency questionnaire. Participants followed
lipid lowering diet for 12 weeks. Energy intake of omega-6 and omega-3 FA was changed from 7.6%
and 0.6% to 5.7% and 1.2%, respectively. Marked decrease in four FA ratios in serum phospholipids,
i.e., omega-6/omega-3, arachidonic acid (AA)/eicosapentaenoic acid (EPA), AA/docosahexaenoic acid
(DHA), AA/(EPA+DHA) and omega-3 index (EPA+DHA) was found in study subjects after lipid-
lowering diet. Total cholesterol/high-density lipoprotein (HDL), low-density lipoprotein (LDL)/
HDL and triacylglycerol/HDL-cholesterol ratios positively correlated with all FA ratios, and negatively
correlated with total omega-3 levels in serum phospholipids and omega-3 index in erythrocytes. Total
serum omega-3 levels showed strongest association with lipoprotein ratios and positive correlation with
homeostatic model assessment (HOMA) index. In conclusion, lipid-lowering diet resulted in decreased
serum key FA ratios, increased omega-3 levels, and improved insulin sensitivity that may lead to a lower
risk of cardiovascular disease in subjects with moderate hyperlipidemia.",
publisher = "Klinicka bolnica Sestre Milosrdnice",
journal = "Acta clinica Croatica",
title = "Efficacy of a Lipid-Lowering Diet on Key Fatty Acid Ratios and Omega-3 Index in Hyperlipidemic Subjects",
pages = "226-220",
number = "2",
volume = "61",
doi = "10.20471/acc.2022.61.02.08"
}

Ristić-Medić, D., Petrović, S., Takić, M., Vučić, V., Arsić, A., Rađen, S.,& Glibetić, M.. (2022). Efficacy of a Lipid-Lowering Diet on Key Fatty Acid Ratios and Omega-3 Index in Hyperlipidemic Subjects. in Acta clinica Croatica
Klinicka bolnica Sestre Milosrdnice., 61(2), 220-226.
https://doi.org/10.20471/acc.2022.61.02.08

Ristić-Medić D, Petrović S, Takić M, Vučić V, Arsić A, Rađen S, Glibetić M. Efficacy of a Lipid-Lowering Diet on Key Fatty Acid Ratios and Omega-3 Index in Hyperlipidemic Subjects. in Acta clinica Croatica. 2022;61(2):220-226.
doi:10.20471/acc.2022.61.02.08 .

Ristić-Medić, Danijela, Petrović, Snježana, Takić, Marija, Vučić, Vesna, Arsić, Aleksandra, Rađen, Slavica, Glibetić, Marija, "Efficacy of a Lipid-Lowering Diet on Key Fatty Acid Ratios and Omega-3 Index in Hyperlipidemic Subjects" in Acta clinica Croatica, 61, no. 2 (2022):220-226,
https://doi.org/10.20471/acc.2022.61.02.08 . .

TY  - JOUR
AU  - Popović, Tamara B.
AU  - Šarić, Bojana
AU  - Debeljak-Martačić, Jasmina
AU  - Arsić, Aleksandra
AU  - Jovanov, Pavle T.
AU  - Stokić, Edita
AU  - Mišan, Aleksandra
AU  - Mandić, Anamarija
PY  - 2022
PY  - 2022
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1264
AB  - The fruit juice industry generates pomace as a valuable by-product especially rich in polyphenols, dietary fibers, vitamins, minerals, and unsaturated fatty acids. In the cookies used in this study, 30% of the gluten-free flour was replaced with dried and ground blueberry and raspberry pomace, rich source of polyphenols, dietary fibers, linoleic and alpha-linolenic acid. In order to examine whether the addition of blueberry and raspberry pomace in cookie formulation can have beneficial effects on certain blood parameters and anthropometric measurements, the designed cookies were tested in 20 healthy, normally fed female subjects, aged 30–50 years (41.35 ± 8.58 years) over four-week dietetic intervention study. Significant changes in the composition of fatty acids serum phospholipids, decrease in LDL-cholesterol level (20.16%), increase in adiponectin level (25.52%) and decrease in ALT and AST values were observed, thus indicating that inclusion of cookies containing blueberry and raspberry dried and ground pomace to usual diet might have positive effects on certain cardiovascular risk factors and liver function indicators.
PB  - Frontiers Media S.A.
T2  - Frontiers in Nutrition
T2  - Frontiers in Nutrition
T1  - Potential health benefits of blueberry and raspberry pomace as functional food ingredients: Dietetic intervention study on healthy women volunteers
SP  - 969996
VL  - 9
DO  - 10.3389/fnut.2022.969996
ER  - 

@article{
author = "Popović, Tamara B. and Šarić, Bojana and Debeljak-Martačić, Jasmina and Arsić, Aleksandra and Jovanov, Pavle T. and Stokić, Edita and Mišan, Aleksandra and Mandić, Anamarija",
year = "2022, 2022",
abstract = "The fruit juice industry generates pomace as a valuable by-product especially rich in polyphenols, dietary fibers, vitamins, minerals, and unsaturated fatty acids. In the cookies used in this study, 30% of the gluten-free flour was replaced with dried and ground blueberry and raspberry pomace, rich source of polyphenols, dietary fibers, linoleic and alpha-linolenic acid. In order to examine whether the addition of blueberry and raspberry pomace in cookie formulation can have beneficial effects on certain blood parameters and anthropometric measurements, the designed cookies were tested in 20 healthy, normally fed female subjects, aged 30–50 years (41.35 ± 8.58 years) over four-week dietetic intervention study. Significant changes in the composition of fatty acids serum phospholipids, decrease in LDL-cholesterol level (20.16%), increase in adiponectin level (25.52%) and decrease in ALT and AST values were observed, thus indicating that inclusion of cookies containing blueberry and raspberry dried and ground pomace to usual diet might have positive effects on certain cardiovascular risk factors and liver function indicators.",
publisher = "Frontiers Media S.A.",
journal = "Frontiers in Nutrition, Frontiers in Nutrition",
title = "Potential health benefits of blueberry and raspberry pomace as functional food ingredients: Dietetic intervention study on healthy women volunteers",
pages = "969996",
volume = "9",
doi = "10.3389/fnut.2022.969996"
}

Popović, T. B., Šarić, B., Debeljak-Martačić, J., Arsić, A., Jovanov, P. T., Stokić, E., Mišan, A.,& Mandić, A.. (2022). Potential health benefits of blueberry and raspberry pomace as functional food ingredients: Dietetic intervention study on healthy women volunteers. in Frontiers in Nutrition
Frontiers Media S.A.., 9, 969996.
https://doi.org/10.3389/fnut.2022.969996

Popović TB, Šarić B, Debeljak-Martačić J, Arsić A, Jovanov PT, Stokić E, Mišan A, Mandić A. Potential health benefits of blueberry and raspberry pomace as functional food ingredients: Dietetic intervention study on healthy women volunteers. in Frontiers in Nutrition. 2022;9:969996.
doi:10.3389/fnut.2022.969996 .

Popović, Tamara B., Šarić, Bojana, Debeljak-Martačić, Jasmina, Arsić, Aleksandra, Jovanov, Pavle T., Stokić, Edita, Mišan, Aleksandra, Mandić, Anamarija, "Potential health benefits of blueberry and raspberry pomace as functional food ingredients: Dietetic intervention study on healthy women volunteers" in Frontiers in Nutrition, 9 (2022):969996,
https://doi.org/10.3389/fnut.2022.969996 . .

TY  - JOUR
AU  - Arsić, Aleksandra
AU  - Takić, Marija
AU  - Kojadinović, Milica
AU  - Petrović, Snježana
AU  - Paunović, Marija P.
AU  - Vučić, Vesna M.
AU  - Ristić-Medić, Danijela
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1070
AB  - The aim of this study was to compare dietary intake and status of polyunsaturated fatty acids (PUFA) in plasma and erythrocyte phospholipids metabolically healthy and unhealthy, and obese and nonobese persons. Metabolic health status in 171 participants was defined according to criteria for metabolic syndrome. Obese and nonobese metabolically unhealthy persons (MUHO and MUHNO) had higher energy intake of n-6 PUFA (7.82 +/- 1.03 and 7.49 +/- 0.86) and lower intake of n-3 PUFA (0.60 +/- 0.12 and 0.62 +/- 0.11) compared to obese and nonobese metabolically healthy persons (MHO and MHNO) (5.92 +/- 0.63 and 5.72 +/- 0.67; 1.20 +/- 0.07 and 1.22 +/- 0.09, respectively) and a higher n-6/n-3 PUFA ratio. The plasma level of n-6 PUFA was lower in the MUHO and MUHNO groups (38.49 +/- 3.71 and 38.53 +/- 2.19) compared to MHNO (40.90 +/- 2.43), while n-3 PUFA status was lower in obese than in nonobese persons (3.58 +/- 0.79 and 3.50 +/- 1.02 vs. 4.21 +/- 0.80 and 4.06 +/- 1.15). The MHO group had a higher eicosapentaenoic/arachidonic acid ratio and estimated desaturase (SCD16, D6D) and elongase activity in plasma phospholipids compared to MHNO. The low intake of n-3 PUFA is directly associated with metabolic risk factors. These results indicated that obesity is closely associated with low levels of n-3 PUFA in plasma phospholipids, suggesting that dietary modifications including n-3 PUFA supplementation appear to be suitable therapeutic strategy in obese persons.
PB  - Canadian Science Publishing, Ottawa
T2  - Canadian Journal of Physiology & Pharmacology
T1  - Metabolically healthy obesity: is there a link with polyunsaturated fatty acid intake and status?
EP  - 71
IS  - 1
SP  - 64
VL  - 99
DO  - 10.1139/cjpp-2020-0317
ER  - 

@article{
author = "Arsić, Aleksandra and Takić, Marija and Kojadinović, Milica and Petrović, Snježana and Paunović, Marija P. and Vučić, Vesna M. and Ristić-Medić, Danijela",
year = "2021",
abstract = "The aim of this study was to compare dietary intake and status of polyunsaturated fatty acids (PUFA) in plasma and erythrocyte phospholipids metabolically healthy and unhealthy, and obese and nonobese persons. Metabolic health status in 171 participants was defined according to criteria for metabolic syndrome. Obese and nonobese metabolically unhealthy persons (MUHO and MUHNO) had higher energy intake of n-6 PUFA (7.82 +/- 1.03 and 7.49 +/- 0.86) and lower intake of n-3 PUFA (0.60 +/- 0.12 and 0.62 +/- 0.11) compared to obese and nonobese metabolically healthy persons (MHO and MHNO) (5.92 +/- 0.63 and 5.72 +/- 0.67; 1.20 +/- 0.07 and 1.22 +/- 0.09, respectively) and a higher n-6/n-3 PUFA ratio. The plasma level of n-6 PUFA was lower in the MUHO and MUHNO groups (38.49 +/- 3.71 and 38.53 +/- 2.19) compared to MHNO (40.90 +/- 2.43), while n-3 PUFA status was lower in obese than in nonobese persons (3.58 +/- 0.79 and 3.50 +/- 1.02 vs. 4.21 +/- 0.80 and 4.06 +/- 1.15). The MHO group had a higher eicosapentaenoic/arachidonic acid ratio and estimated desaturase (SCD16, D6D) and elongase activity in plasma phospholipids compared to MHNO. The low intake of n-3 PUFA is directly associated with metabolic risk factors. These results indicated that obesity is closely associated with low levels of n-3 PUFA in plasma phospholipids, suggesting that dietary modifications including n-3 PUFA supplementation appear to be suitable therapeutic strategy in obese persons.",
publisher = "Canadian Science Publishing, Ottawa",
journal = "Canadian Journal of Physiology & Pharmacology",
title = "Metabolically healthy obesity: is there a link with polyunsaturated fatty acid intake and status?",
pages = "71-64",
number = "1",
volume = "99",
doi = "10.1139/cjpp-2020-0317"
}

Arsić, A., Takić, M., Kojadinović, M., Petrović, S., Paunović, M. P., Vučić, V. M.,& Ristić-Medić, D.. (2021). Metabolically healthy obesity: is there a link with polyunsaturated fatty acid intake and status?. in Canadian Journal of Physiology & Pharmacology
Canadian Science Publishing, Ottawa., 99(1), 64-71.
https://doi.org/10.1139/cjpp-2020-0317

Arsić A, Takić M, Kojadinović M, Petrović S, Paunović MP, Vučić VM, Ristić-Medić D. Metabolically healthy obesity: is there a link with polyunsaturated fatty acid intake and status?. in Canadian Journal of Physiology & Pharmacology. 2021;99(1):64-71.
doi:10.1139/cjpp-2020-0317 .

Arsić, Aleksandra, Takić, Marija, Kojadinović, Milica, Petrović, Snježana, Paunović, Marija P., Vučić, Vesna M., Ristić-Medić, Danijela, "Metabolically healthy obesity: is there a link with polyunsaturated fatty acid intake and status?" in Canadian Journal of Physiology & Pharmacology, 99, no. 1 (2021):64-71,
https://doi.org/10.1139/cjpp-2020-0317 . .

TY  - JOUR
AU  - Ristić-Medić, Danijela
AU  - Kovačić, Marijana
AU  - Takić, Marija
AU  - Arsić, Aleksandra
AU  - Petrović, Snježana
AU  - Paunović, Marija P.
AU  - Jovicić, Maja
AU  - Vučić, Vesna M.
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1071
AB  - Lifestyle modifications are the main support of nonalcoholic fatty liver disease (NAFLD) therapy. Weight loss is one of the primary goals in NAFLD, but the effects of different calorie-restricted diets remain unclear. Thus, we evaluated the effects of two calorie-restricted diets-the Mediterranean diet (Med diet) and low-fat diet-on liver status, cardiometabolic markers, and fatty acid profiles in patients with NAFLD. Twenty-four overweight/moderately obese men were randomly assigned to consume one of these diets. Lipid levels, glucose, insulin, liver enzymes, steatosis, and fatty acid profiles of serum and erythrocytes phospholipids were assessed. After 3 months, all participants had a significant weight loss ( gt 9%), with improvements in waist circumference, body fat %, index of visceral adiposity (VAI), lipid accumulation product, fatty liver (FLI), and hepatic steatosis (HSI) index (p  lt  0.001). Both diets significantly lowered triglycerides, total and LDL-cholesterol, liver enzymes, fasting glucose, insulin, and HOMA-IR index. Fatty acid profiles were enhanced after both diets, with a significantly decreased n-6/n-3 ratio. Participants on the Med diet had higher levels of HDL-cholesterol and monounsaturated and n-3 docosahexaenoic acids in serum phospholipids and lower levels of saturated fatty acids, triglycerides, TG/HDL ratio, and FLI when compared to participants on the low-fat diet. Our results indicate that dietary patterns and calorie restriction represent central therapeutic issues in the improvement of obesity-related cardiometabolic alterations that are involved in the mechanism of hepatic steatosis. The Med diet may contribute to disease treatment even more than the low-fat diet since it leads to decreased saturated and increased monounsaturated and n-3 polyunsaturated fatty acid status and improved FLI in NAFLD patients.
PB  - MDPI
T2  - Nutrients
T1  - Calorie-Restricted Mediterranean and Low-Fat Diets Affect Fatty Acid Status in Individuals with Nonalcoholic Fatty Liver Disease
IS  - 1
SP  - 15
VL  - 13
DO  - 10.3390/nu13010015
ER  - 

@article{
author = "Ristić-Medić, Danijela and Kovačić, Marijana and Takić, Marija and Arsić, Aleksandra and Petrović, Snježana and Paunović, Marija P. and Jovicić, Maja and Vučić, Vesna M.",
year = "2021",
abstract = "Lifestyle modifications are the main support of nonalcoholic fatty liver disease (NAFLD) therapy. Weight loss is one of the primary goals in NAFLD, but the effects of different calorie-restricted diets remain unclear. Thus, we evaluated the effects of two calorie-restricted diets-the Mediterranean diet (Med diet) and low-fat diet-on liver status, cardiometabolic markers, and fatty acid profiles in patients with NAFLD. Twenty-four overweight/moderately obese men were randomly assigned to consume one of these diets. Lipid levels, glucose, insulin, liver enzymes, steatosis, and fatty acid profiles of serum and erythrocytes phospholipids were assessed. After 3 months, all participants had a significant weight loss ( gt 9%), with improvements in waist circumference, body fat %, index of visceral adiposity (VAI), lipid accumulation product, fatty liver (FLI), and hepatic steatosis (HSI) index (p  lt  0.001). Both diets significantly lowered triglycerides, total and LDL-cholesterol, liver enzymes, fasting glucose, insulin, and HOMA-IR index. Fatty acid profiles were enhanced after both diets, with a significantly decreased n-6/n-3 ratio. Participants on the Med diet had higher levels of HDL-cholesterol and monounsaturated and n-3 docosahexaenoic acids in serum phospholipids and lower levels of saturated fatty acids, triglycerides, TG/HDL ratio, and FLI when compared to participants on the low-fat diet. Our results indicate that dietary patterns and calorie restriction represent central therapeutic issues in the improvement of obesity-related cardiometabolic alterations that are involved in the mechanism of hepatic steatosis. The Med diet may contribute to disease treatment even more than the low-fat diet since it leads to decreased saturated and increased monounsaturated and n-3 polyunsaturated fatty acid status and improved FLI in NAFLD patients.",
publisher = "MDPI",
journal = "Nutrients",
title = "Calorie-Restricted Mediterranean and Low-Fat Diets Affect Fatty Acid Status in Individuals with Nonalcoholic Fatty Liver Disease",
number = "1",
pages = "15",
volume = "13",
doi = "10.3390/nu13010015"
}

Ristić-Medić, D., Kovačić, M., Takić, M., Arsić, A., Petrović, S., Paunović, M. P., Jovicić, M.,& Vučić, V. M.. (2021). Calorie-Restricted Mediterranean and Low-Fat Diets Affect Fatty Acid Status in Individuals with Nonalcoholic Fatty Liver Disease. in Nutrients
MDPI., 13(1), 15.
https://doi.org/10.3390/nu13010015

Ristić-Medić D, Kovačić M, Takić M, Arsić A, Petrović S, Paunović MP, Jovicić M, Vučić VM. Calorie-Restricted Mediterranean and Low-Fat Diets Affect Fatty Acid Status in Individuals with Nonalcoholic Fatty Liver Disease. in Nutrients. 2021;13(1):15.
doi:10.3390/nu13010015 .

Ristić-Medić, Danijela, Kovačić, Marijana, Takić, Marija, Arsić, Aleksandra, Petrović, Snježana, Paunović, Marija P., Jovicić, Maja, Vučić, Vesna M., "Calorie-Restricted Mediterranean and Low-Fat Diets Affect Fatty Acid Status in Individuals with Nonalcoholic Fatty Liver Disease" in Nutrients, 13, no. 1 (2021):15,
https://doi.org/10.3390/nu13010015 . .

TY  - JOUR
AU  - Ristić-Medić, Danijela
AU  - Petrović, Snježana
AU  - Arsić, Aleksandra
AU  - Vučić, Vesna M.
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1166
AB  - Varying degrees of liver injuries have been reported in patients infected with the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). In general, oxidative stress is actively involved in initiation and progression of liver damage. The liver metabolizes various compounds that produce free radicals. Maintaining the oxidative/antioxidative balance is important in coronavirus disease 2019 (COVID-19) patients. Antioxidant vitamins, essential trace elements and food compounds, such as polyphenols, appear to be promising agents, with effects in oxidative burst. Deficiency of these nutrients suppresses immune function and increases susceptibility to COVID-19. Daily micronutrient intake is necessary to support anti-inflammatory and antioxidative effects but for immune function may be higher than current recommended dietary intake. Antioxidant supplements (βcarotene, vitamin A, vitamin C, vitamin E, and selenium) could have a potential role in patients with liver damage. Available evidence suggests that supplementing the diet with a combination of micronutrients may help to optimize immune function and reduce the risk of infection. Clinical trials based on the associations of diet and SARS-CoV-2 infection are lacking. Unfortunately, it is not possible to definitively determine the dose, route of administration and best timing to intervene with antioxidants in COVID-19 patients because clinical trials are still ongoing. Until then, hopefully, this review will enable clinicians to understand the impact of micronutrient dietary intake and liver status assessment in COVID-19 patients.
PB  - Baishideng Publishing Group
T2  - World Journal of Gastroenterology
T1  - Liver disease and COVID-19: The link with oxidative stress, antioxidants and nutrition
EP  - 5699
IS  - 34
SP  - 5682
VL  - 27
DO  - 10.3748/wjg.v27.i34.5682
ER  - 

@article{
author = "Ristić-Medić, Danijela and Petrović, Snježana and Arsić, Aleksandra and Vučić, Vesna M.",
year = "2021",
abstract = "Varying degrees of liver injuries have been reported in patients infected with the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). In general, oxidative stress is actively involved in initiation and progression of liver damage. The liver metabolizes various compounds that produce free radicals. Maintaining the oxidative/antioxidative balance is important in coronavirus disease 2019 (COVID-19) patients. Antioxidant vitamins, essential trace elements and food compounds, such as polyphenols, appear to be promising agents, with effects in oxidative burst. Deficiency of these nutrients suppresses immune function and increases susceptibility to COVID-19. Daily micronutrient intake is necessary to support anti-inflammatory and antioxidative effects but for immune function may be higher than current recommended dietary intake. Antioxidant supplements (βcarotene, vitamin A, vitamin C, vitamin E, and selenium) could have a potential role in patients with liver damage. Available evidence suggests that supplementing the diet with a combination of micronutrients may help to optimize immune function and reduce the risk of infection. Clinical trials based on the associations of diet and SARS-CoV-2 infection are lacking. Unfortunately, it is not possible to definitively determine the dose, route of administration and best timing to intervene with antioxidants in COVID-19 patients because clinical trials are still ongoing. Until then, hopefully, this review will enable clinicians to understand the impact of micronutrient dietary intake and liver status assessment in COVID-19 patients.",
publisher = "Baishideng Publishing Group",
journal = "World Journal of Gastroenterology",
title = "Liver disease and COVID-19: The link with oxidative stress, antioxidants and nutrition",
pages = "5699-5682",
number = "34",
volume = "27",
doi = "10.3748/wjg.v27.i34.5682"
}

Ristić-Medić, D., Petrović, S., Arsić, A.,& Vučić, V. M.. (2021). Liver disease and COVID-19: The link with oxidative stress, antioxidants and nutrition. in World Journal of Gastroenterology
Baishideng Publishing Group., 27(34), 5682-5699.
https://doi.org/10.3748/wjg.v27.i34.5682

Ristić-Medić D, Petrović S, Arsić A, Vučić VM. Liver disease and COVID-19: The link with oxidative stress, antioxidants and nutrition. in World Journal of Gastroenterology. 2021;27(34):5682-5699.
doi:10.3748/wjg.v27.i34.5682 .

Ristić-Medić, Danijela, Petrović, Snježana, Arsić, Aleksandra, Vučić, Vesna M., "Liver disease and COVID-19: The link with oxidative stress, antioxidants and nutrition" in World Journal of Gastroenterology, 27, no. 34 (2021):5682-5699,
https://doi.org/10.3748/wjg.v27.i34.5682 . .

TY  - JOUR
AU  - Milošević, Maja
AU  - Arsić, Aleksandra
AU  - Cvetković, Zorica
AU  - Vučić, Vesna M.
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1153
AB  - Healthcare systems worldwide are seriously challenged by a rising prevalence of neurodegenerative diseases (NDDs), which mostly, but not exclusively, affect the ever-growing population of the elderly. The most known neurodegenerative diseases are Alzheimer's (AD) and Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis, but some viral infections of the brain and traumatic brain injury may also cause NDD. Typical for NDD are the malfunctioning of neurons and their irreversible loss, which often progress irreversibly to dementia and ultimately to death. Numerous factors are involved in the pathogenesis of NDD: genetic variability, epigenetic changes, extent of oxidative/nitrosative stress, mitochondrial dysfunction, and DNA damage. The complex interplay of all the above-mentioned factors may be a fingerprint of neurodegeneration, with different diseases being affected to different extents by particular factors. There is a voluminous body of evidence showing the benefits of regular exercise to brain health and cognitive functions. Moreover, the importance of a healthy diet, balanced in macro- and micro-nutrients, in preventing neurodegeneration and slowing down a progression to full-blown disease is evident. Individuals affected by NDD almost inevitably have low-grade inflammation and anomalies in lipid metabolism. Metabolic and lipid profiles in NDD can be improved by the Mediterranean diet. Many studies have associated the Mediterranean diet with a decreased risk of dementia and AD, but a cause-and-effect relationship has not been deduced. Studies with caloric restriction showed neuroprotective effects in animal models, but the results in humans are inconsistent. The pathologies of NDD are complex and there is a great inter-individual (epi)genetic variance within any population. Furthermore, the gut microbiome, being deeply involved in nutrient uptake and lipid metabolism, also represents a pillar of the gut microbiome–brain axis and is linked with the pathogenesis of NDD. Numerous studies on the role of different micronutrients (omega-3 fatty acids, bioactive polyphenols from fruit and medicinal plants) in the prevention, prediction, and treatment of NDD have been conducted, but we are still far away from a personalized diet plan for individual NDD patients. For this to be realized, large-scale cohorts that would include the precise monitoring of food intake, mapping of genetic variants, epigenetic data, microbiome studies, and metabolome, lipidome, and transcriptome data are needed.
PB  - Frontiers Media S.A.
T2  - Frontiers in Nutrition
T1  - Memorable Food: Fighting Age-Related Neurodegeneration by Precision Nutrition
SP  - 688086
VL  - 8
DO  - 10.3389/fnut.2021.688086
ER  - 

@article{
author = "Milošević, Maja and Arsić, Aleksandra and Cvetković, Zorica and Vučić, Vesna M.",
year = "2021",
abstract = "Healthcare systems worldwide are seriously challenged by a rising prevalence of neurodegenerative diseases (NDDs), which mostly, but not exclusively, affect the ever-growing population of the elderly. The most known neurodegenerative diseases are Alzheimer's (AD) and Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis, but some viral infections of the brain and traumatic brain injury may also cause NDD. Typical for NDD are the malfunctioning of neurons and their irreversible loss, which often progress irreversibly to dementia and ultimately to death. Numerous factors are involved in the pathogenesis of NDD: genetic variability, epigenetic changes, extent of oxidative/nitrosative stress, mitochondrial dysfunction, and DNA damage. The complex interplay of all the above-mentioned factors may be a fingerprint of neurodegeneration, with different diseases being affected to different extents by particular factors. There is a voluminous body of evidence showing the benefits of regular exercise to brain health and cognitive functions. Moreover, the importance of a healthy diet, balanced in macro- and micro-nutrients, in preventing neurodegeneration and slowing down a progression to full-blown disease is evident. Individuals affected by NDD almost inevitably have low-grade inflammation and anomalies in lipid metabolism. Metabolic and lipid profiles in NDD can be improved by the Mediterranean diet. Many studies have associated the Mediterranean diet with a decreased risk of dementia and AD, but a cause-and-effect relationship has not been deduced. Studies with caloric restriction showed neuroprotective effects in animal models, but the results in humans are inconsistent. The pathologies of NDD are complex and there is a great inter-individual (epi)genetic variance within any population. Furthermore, the gut microbiome, being deeply involved in nutrient uptake and lipid metabolism, also represents a pillar of the gut microbiome–brain axis and is linked with the pathogenesis of NDD. Numerous studies on the role of different micronutrients (omega-3 fatty acids, bioactive polyphenols from fruit and medicinal plants) in the prevention, prediction, and treatment of NDD have been conducted, but we are still far away from a personalized diet plan for individual NDD patients. For this to be realized, large-scale cohorts that would include the precise monitoring of food intake, mapping of genetic variants, epigenetic data, microbiome studies, and metabolome, lipidome, and transcriptome data are needed.",
publisher = "Frontiers Media S.A.",
journal = "Frontiers in Nutrition",
title = "Memorable Food: Fighting Age-Related Neurodegeneration by Precision Nutrition",
pages = "688086",
volume = "8",
doi = "10.3389/fnut.2021.688086"
}

Milošević, M., Arsić, A., Cvetković, Z.,& Vučić, V. M.. (2021). Memorable Food: Fighting Age-Related Neurodegeneration by Precision Nutrition. in Frontiers in Nutrition
Frontiers Media S.A.., 8, 688086.
https://doi.org/10.3389/fnut.2021.688086

Milošević M, Arsić A, Cvetković Z, Vučić VM. Memorable Food: Fighting Age-Related Neurodegeneration by Precision Nutrition. in Frontiers in Nutrition. 2021;8:688086.
doi:10.3389/fnut.2021.688086 .

Milošević, Maja, Arsić, Aleksandra, Cvetković, Zorica, Vučić, Vesna M., "Memorable Food: Fighting Age-Related Neurodegeneration by Precision Nutrition" in Frontiers in Nutrition, 8 (2021):688086,
https://doi.org/10.3389/fnut.2021.688086 . .

TY  - JOUR
AU  - Krstić, Predrag
AU  - Vučić, Vesna M.
AU  - Paunović, Marija
AU  - Petrović, Snjezana
AU  - Nedović, Nikola
AU  - Kostić, Sanja
AU  - Arsić, Aleksandra
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1219
AB  - Background/Aim. Dysregulation of fatty acid (FA) me-tabolism is recognized as a component of malignant trans-formation in many cancers, including breast cancer (BC), and is often related to disease progression and prognosis. Adjuvant endocrine BC therapy using aromatase inhibitors may also influence FA metabolism. Thus, the aim of our study was to compare plasma total lipids FA status in new-ly diagnosed postmenopausal patients with BC and in postmenopausal women with BC receiving aromatase in-hibitors at least 2 years after completing chemotherapy with healthy women. Methods. The study included 17 newly diagnosed postmenopausal BC patients (ND group) and 21 postmenopausal women with BC receiving aroma-tase inhibitor therapy 2 years after ending chemotherapy (AI group), while a total of 15 apparently healthy women without a family history of BC, comparable in age and body mass index, served as a control group. Results. In both patient groups, we found significantly lower levels of vaccenic acid (18:1n-7), alpha-linolenic acid (18:3n-3), gamma-linolenic acid (GLA, 18:3n-6), and docosapentae-noic acid (22:5n-3), and a significantly higher level of di-homo-gamma-linolenic (20:3n-6), when compared with the control group. On the other hand, a significantly lower level of stearic acid (18:0) was observed only in AI pa-tients, while the level of linoleic acid (18:2n-6) was signifi-cantly higher in ND women than in the control group. Reduced estimated activities of D6 and D5 desaturases were found in both patient groups than in the control group. Conclusion. Our results indicate that FA profiles of plasma lipids of the newly diagnosed, untreated BC pa-tients are very similar to those of cured BC patients who underwent all sessions of chemotherapy and received aromatase inhibitors for at least two years. Additionally, according to our results, their FA profiles markedly differ from those of healthy women. Therefore, supplementation with omega-3 FA and GLA could have beneficial effects in these patients, and further studies should address the potential clinical benefits of the supplementation.
AB  - Uvod/Cilj. Promene u metabolizmu masnih kiselina prepoznate su kao komponenta maligne transformacije u mnogim različitim vrstama kancera, uključujući i karcinom dojke (KD), a često su povezane sa progresijom i prognozom bolesti. Adjuvantna endokrina terapija KD, korišćenjem inhibitora aromataze, takođe može uticati na metabolizam masnih kiselina (MK). Zbog toga je cilj ovog rada bio da se uporede MK profili iz ukupnih lipida plazme kod žena u menopauzi, a kojima je dijagnostikovan KD, i onih sa KD koje su na terapiji inhibitorima aromataze najmanje dve godine, sa MK profilima kontrolne grupe. Metode. U studiju je bilo uključeno 17 žena sa novodijag- nostikovanim KD (ND grupi) i 21 žena sa KD koje su na terapiji inhibitorima aromataze (AI grupi). Kontrolnu grupu je činilo 15 uslovno zdravih žena u menopauzi koje nisu imale porodičnu anamnezu za KD i koje su po godinama i indeksu telesne mase poređene sa bolesnicama. Rezultati. Procenat vakcenske (18:1n-7), alfa-linolenske (18:3n-3), ga- ma-linolenske (18:3n-6) i dokozapentaenske (22:5n-3) kis- eline bio je značajno niži, dok je procenat dihomo-gama- linolenske kiseline (20:3n-6) bio značajno viši, kod obe grupe bolesnica u odnosu na kontrolnu grupu. Sa druge strane, niži nivo stearinske kiseline (18:0) pronašli smo u samo AI grupi, dok je visok nivo linolne kiseline (18:2n-6) utvrđen samo u ND grupi u odnosu na kontrolu. Smanjena procenjena ak- tivnost D6 i D5 desaturaze nađena je kod obe grupe bolesni- ca u odnosu na kontrolnu grupu. Zaključak. Naši rezultati su pokazali veoma sličan MK profil kod žena sa tek dijagnos- tikovanim KD i onih koje su na terapiji inhibitorima aroma- taze najkraće dve godine, ali i da se njihovi MK profili u ve- likoj meri razlikuju od MK profila kontrolne grupe. Zbog to- ga, suplementacija n-3 masnim kiselinama i gama linolenskom kiselinom može biti korisna za ove bolesnice, i buduće studije bi mogle ispitivati potencijalnu korist ovih suplemenata.
PB  - Vojnomedicinska akademija, Institut za naučne informacije
T2  - Vojnosanitetski pregled
T1  - Similar fatty acid status of plasma lipids in postmenopausal women newly diagnosed with breast cancer and those receiving aromatase inhibitor therapy
T1  - Sličan masnokiselinski status kod žena sa novodijagnostikovanim karcinomom
dojke i onih koje su na terapiji inhibitorima aromataze
EP  - 1145
IS  - 11
SP  - 1140
VL  - 78
DO  - 10.2298/VSP200124032K
ER  - 

@article{
author = "Krstić, Predrag and Vučić, Vesna M. and Paunović, Marija and Petrović, Snjezana and Nedović, Nikola and Kostić, Sanja and Arsić, Aleksandra",
year = "2021",
abstract = "Background/Aim. Dysregulation of fatty acid (FA) me-tabolism is recognized as a component of malignant trans-formation in many cancers, including breast cancer (BC), and is often related to disease progression and prognosis. Adjuvant endocrine BC therapy using aromatase inhibitors may also influence FA metabolism. Thus, the aim of our study was to compare plasma total lipids FA status in new-ly diagnosed postmenopausal patients with BC and in postmenopausal women with BC receiving aromatase in-hibitors at least 2 years after completing chemotherapy with healthy women. Methods. The study included 17 newly diagnosed postmenopausal BC patients (ND group) and 21 postmenopausal women with BC receiving aroma-tase inhibitor therapy 2 years after ending chemotherapy (AI group), while a total of 15 apparently healthy women without a family history of BC, comparable in age and body mass index, served as a control group. Results. In both patient groups, we found significantly lower levels of vaccenic acid (18:1n-7), alpha-linolenic acid (18:3n-3), gamma-linolenic acid (GLA, 18:3n-6), and docosapentae-noic acid (22:5n-3), and a significantly higher level of di-homo-gamma-linolenic (20:3n-6), when compared with the control group. On the other hand, a significantly lower level of stearic acid (18:0) was observed only in AI pa-tients, while the level of linoleic acid (18:2n-6) was signifi-cantly higher in ND women than in the control group. Reduced estimated activities of D6 and D5 desaturases were found in both patient groups than in the control group. Conclusion. Our results indicate that FA profiles of plasma lipids of the newly diagnosed, untreated BC pa-tients are very similar to those of cured BC patients who underwent all sessions of chemotherapy and received aromatase inhibitors for at least two years. Additionally, according to our results, their FA profiles markedly differ from those of healthy women. Therefore, supplementation with omega-3 FA and GLA could have beneficial effects in these patients, and further studies should address the potential clinical benefits of the supplementation., Uvod/Cilj. Promene u metabolizmu masnih kiselina prepoznate su kao komponenta maligne transformacije u mnogim različitim vrstama kancera, uključujući i karcinom dojke (KD), a često su povezane sa progresijom i prognozom bolesti. Adjuvantna endokrina terapija KD, korišćenjem inhibitora aromataze, takođe može uticati na metabolizam masnih kiselina (MK). Zbog toga je cilj ovog rada bio da se uporede MK profili iz ukupnih lipida plazme kod žena u menopauzi, a kojima je dijagnostikovan KD, i onih sa KD koje su na terapiji inhibitorima aromataze najmanje dve godine, sa MK profilima kontrolne grupe. Metode. U studiju je bilo uključeno 17 žena sa novodijag- nostikovanim KD (ND grupi) i 21 žena sa KD koje su na terapiji inhibitorima aromataze (AI grupi). Kontrolnu grupu je činilo 15 uslovno zdravih žena u menopauzi koje nisu imale porodičnu anamnezu za KD i koje su po godinama i indeksu telesne mase poređene sa bolesnicama. Rezultati. Procenat vakcenske (18:1n-7), alfa-linolenske (18:3n-3), ga- ma-linolenske (18:3n-6) i dokozapentaenske (22:5n-3) kis- eline bio je značajno niži, dok je procenat dihomo-gama- linolenske kiseline (20:3n-6) bio značajno viši, kod obe grupe bolesnica u odnosu na kontrolnu grupu. Sa druge strane, niži nivo stearinske kiseline (18:0) pronašli smo u samo AI grupi, dok je visok nivo linolne kiseline (18:2n-6) utvrđen samo u ND grupi u odnosu na kontrolu. Smanjena procenjena ak- tivnost D6 i D5 desaturaze nađena je kod obe grupe bolesni- ca u odnosu na kontrolnu grupu. Zaključak. Naši rezultati su pokazali veoma sličan MK profil kod žena sa tek dijagnos- tikovanim KD i onih koje su na terapiji inhibitorima aroma- taze najkraće dve godine, ali i da se njihovi MK profili u ve- likoj meri razlikuju od MK profila kontrolne grupe. Zbog to- ga, suplementacija n-3 masnim kiselinama i gama linolenskom kiselinom može biti korisna za ove bolesnice, i buduće studije bi mogle ispitivati potencijalnu korist ovih suplemenata.",
publisher = "Vojnomedicinska akademija, Institut za naučne informacije",
journal = "Vojnosanitetski pregled",
title = "Similar fatty acid status of plasma lipids in postmenopausal women newly diagnosed with breast cancer and those receiving aromatase inhibitor therapy, Sličan masnokiselinski status kod žena sa novodijagnostikovanim karcinomom
dojke i onih koje su na terapiji inhibitorima aromataze",
pages = "1145-1140",
number = "11",
volume = "78",
doi = "10.2298/VSP200124032K"
}

Krstić, P., Vučić, V. M., Paunović, M., Petrović, S., Nedović, N., Kostić, S.,& Arsić, A.. (2021). Similar fatty acid status of plasma lipids in postmenopausal women newly diagnosed with breast cancer and those receiving aromatase inhibitor therapy. in Vojnosanitetski pregled
Vojnomedicinska akademija, Institut za naučne informacije., 78(11), 1140-1145.
https://doi.org/10.2298/VSP200124032K

Krstić P, Vučić VM, Paunović M, Petrović S, Nedović N, Kostić S, Arsić A. Similar fatty acid status of plasma lipids in postmenopausal women newly diagnosed with breast cancer and those receiving aromatase inhibitor therapy. in Vojnosanitetski pregled. 2021;78(11):1140-1145.
doi:10.2298/VSP200124032K .

Krstić, Predrag, Vučić, Vesna M., Paunović, Marija, Petrović, Snjezana, Nedović, Nikola, Kostić, Sanja, Arsić, Aleksandra, "Similar fatty acid status of plasma lipids in postmenopausal women newly diagnosed with breast cancer and those receiving aromatase inhibitor therapy" in Vojnosanitetski pregled, 78, no. 11 (2021):1140-1145,
https://doi.org/10.2298/VSP200124032K . .

TY  - JOUR
AU  - Kojadinović, Milica
AU  - Glibetić, Marija
AU  - Vučić, Vesna M.
AU  - Popović, Milica
AU  - Vidović, Nevena Đ.
AU  - Debeljak-Martačić, Jasmina
AU  - Arsić, Aleksandra
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/9
AB  - Pomegranate juice (PJ) has potential positive effects in patients with metabolic disturbances due to a high content of polyphenols. The objective of this study was to evaluate effects of a 2-week consumption of dietary doses of PJ on blood pressure, lipid metabolism, and oxidative stress markers in overweight patients with dyslipidemia. Twenty-four patients, 8 males and 16 females, 40-60 years of age, with established overweight and dyslipidemia were randomly assigned into intervention group, who consumed 300 mL of PJ daily for 2 weeks, or control group. After 2 weeks of juice intake, intervention group had significantly lower diastolic blood pressure, low-density lipoprotein cholesterol, aminotransferase, and activity of glutathione peroxidase. Furthermore, patients who consumed PJ had reduced percentage of docosahexaenoic acid (22:6n-3, DHA) in plasma phospholipids and increased estimated activity of stearoyl-CoA desaturase. In erythrocytes, we found a significant increase in the levels of dihomo-gamma- linolenic acid (20:3n-6, DGLA) and DHA, as well as in estimated activity of Delta 6 desaturase, and a decrease in estimated activity of Delta 5 desaturase. These results show that even a short-term consumption of dietary doses of PJ exerts beneficial effects and affects lipid metabolism in overweight patients with dyslipidemia.
PB  - Mary Ann Liebert, Inc, New Rochelle
T2  - Journal of Medicinal Food
T1  - Short-Term Consumption of Pomegranate Juice Alleviates Some Metabolic Disturbances in Overweight Patients with Dyslipidemia
DO  - 10.1089/jmf.2020.0122
ER  - 

@article{
author = "Kojadinović, Milica and Glibetić, Marija and Vučić, Vesna M. and Popović, Milica and Vidović, Nevena Đ. and Debeljak-Martačić, Jasmina and Arsić, Aleksandra",
year = "2021",
abstract = "Pomegranate juice (PJ) has potential positive effects in patients with metabolic disturbances due to a high content of polyphenols. The objective of this study was to evaluate effects of a 2-week consumption of dietary doses of PJ on blood pressure, lipid metabolism, and oxidative stress markers in overweight patients with dyslipidemia. Twenty-four patients, 8 males and 16 females, 40-60 years of age, with established overweight and dyslipidemia were randomly assigned into intervention group, who consumed 300 mL of PJ daily for 2 weeks, or control group. After 2 weeks of juice intake, intervention group had significantly lower diastolic blood pressure, low-density lipoprotein cholesterol, aminotransferase, and activity of glutathione peroxidase. Furthermore, patients who consumed PJ had reduced percentage of docosahexaenoic acid (22:6n-3, DHA) in plasma phospholipids and increased estimated activity of stearoyl-CoA desaturase. In erythrocytes, we found a significant increase in the levels of dihomo-gamma- linolenic acid (20:3n-6, DGLA) and DHA, as well as in estimated activity of Delta 6 desaturase, and a decrease in estimated activity of Delta 5 desaturase. These results show that even a short-term consumption of dietary doses of PJ exerts beneficial effects and affects lipid metabolism in overweight patients with dyslipidemia.",
publisher = "Mary Ann Liebert, Inc, New Rochelle",
journal = "Journal of Medicinal Food",
title = "Short-Term Consumption of Pomegranate Juice Alleviates Some Metabolic Disturbances in Overweight Patients with Dyslipidemia",
doi = "10.1089/jmf.2020.0122"
}

Kojadinović, M., Glibetić, M., Vučić, V. M., Popović, M., Vidović, N. Đ., Debeljak-Martačić, J.,& Arsić, A.. (2021). Short-Term Consumption of Pomegranate Juice Alleviates Some Metabolic Disturbances in Overweight Patients with Dyslipidemia. in Journal of Medicinal Food
Mary Ann Liebert, Inc, New Rochelle..
https://doi.org/10.1089/jmf.2020.0122

Kojadinović M, Glibetić M, Vučić VM, Popović M, Vidović NĐ, Debeljak-Martačić J, Arsić A. Short-Term Consumption of Pomegranate Juice Alleviates Some Metabolic Disturbances in Overweight Patients with Dyslipidemia. in Journal of Medicinal Food. 2021;.
doi:10.1089/jmf.2020.0122 .

Kojadinović, Milica, Glibetić, Marija, Vučić, Vesna M., Popović, Milica, Vidović, Nevena Đ., Debeljak-Martačić, Jasmina, Arsić, Aleksandra, "Short-Term Consumption of Pomegranate Juice Alleviates Some Metabolic Disturbances in Overweight Patients with Dyslipidemia" in Journal of Medicinal Food (2021),
https://doi.org/10.1089/jmf.2020.0122 . .

TY  - JOUR
AU  - Kovačić, Marijana
AU  - Fratrić, Natalija
AU  - Arsić, Aleksandra
AU  - Mojsilović, Slavko
AU  - Drvenica, Ivana
AU  - Marković, Dragana
AU  - Maslovarić, Irina
AU  - Grujić-Milanović, Jelica
AU  - Ivanov, Milan
AU  - Ilić, Vesna
PY  - 2020
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1010
AB  - Calf bronchopneumonia is accompanied by increased level of circulating immune complexes (CIC), and we analysed size, and protein and lipid constituents of these CIC with an attempt to elucidate the connection between the CIC structural properties and their capacity to modulate leukocyte function. CIC of heathy calves (CICH) and calves with naturally occurring bronchopneumonia (CICD) were isolated by PEG precipitation and analysed by electrophoresis and chromatography. The predominant CIC proteins were IgG, albumin, and transferrin. Affinity isolated serum and CIC IgG coprecipitated several proteins, but only 75 and 80 kDa proteins bound CIC IgG, exclusively. 60 and 65 kDa proteins co-precipitated with CICD IgG, unlike CICH IgG. In both CICH and CICD, oleic acid-containing phospholipids predominated. In CICD, the content of oleic and vaccenic acid was higher than in CICH, while myristic, palmitic, stearic, linoleic and arachidonic acid showed lower content. Dynamic light scattering displayed difference in particle size distribution between CICH and CICD; 1280 nm large particles were present only in CICD. The effect of CICH and CICD on mononuclear cells (MNC) and granulocytes was analysed in vitro. CICH and CICD, with slight difference in intensity, stimulate MNC apoptosis, promote cell cycle arrest of unstimulated MNC, and cell cycle progression of PHA stimulated MNC. Both CIC reduced granulocyte apoptosis after 24 h while after 48 h this effect was detected for CICD only. These results indicate that structural differences of CICH and CICD might interfere with the CIC functional capacity, which we consider important for evaluation of CIC immunoregulatory function.
PB  - Elsevier Sci Ltd, Oxford
T2  - Research in Veterinary Science
T1  - Structural characteristics of circulating immune complexes in calves with bronchopneumonia: Impact on the quiescent leukocytes
EP  - 74
SP  - 63
VL  - 133
DO  - 10.1016/j.rvsc.2020.09.004
ER  - 

@article{
author = "Kovačić, Marijana and Fratrić, Natalija and Arsić, Aleksandra and Mojsilović, Slavko and Drvenica, Ivana and Marković, Dragana and Maslovarić, Irina and Grujić-Milanović, Jelica and Ivanov, Milan and Ilić, Vesna",
year = "2020",
abstract = "Calf bronchopneumonia is accompanied by increased level of circulating immune complexes (CIC), and we analysed size, and protein and lipid constituents of these CIC with an attempt to elucidate the connection between the CIC structural properties and their capacity to modulate leukocyte function. CIC of heathy calves (CICH) and calves with naturally occurring bronchopneumonia (CICD) were isolated by PEG precipitation and analysed by electrophoresis and chromatography. The predominant CIC proteins were IgG, albumin, and transferrin. Affinity isolated serum and CIC IgG coprecipitated several proteins, but only 75 and 80 kDa proteins bound CIC IgG, exclusively. 60 and 65 kDa proteins co-precipitated with CICD IgG, unlike CICH IgG. In both CICH and CICD, oleic acid-containing phospholipids predominated. In CICD, the content of oleic and vaccenic acid was higher than in CICH, while myristic, palmitic, stearic, linoleic and arachidonic acid showed lower content. Dynamic light scattering displayed difference in particle size distribution between CICH and CICD; 1280 nm large particles were present only in CICD. The effect of CICH and CICD on mononuclear cells (MNC) and granulocytes was analysed in vitro. CICH and CICD, with slight difference in intensity, stimulate MNC apoptosis, promote cell cycle arrest of unstimulated MNC, and cell cycle progression of PHA stimulated MNC. Both CIC reduced granulocyte apoptosis after 24 h while after 48 h this effect was detected for CICD only. These results indicate that structural differences of CICH and CICD might interfere with the CIC functional capacity, which we consider important for evaluation of CIC immunoregulatory function.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Research in Veterinary Science",
title = "Structural characteristics of circulating immune complexes in calves with bronchopneumonia: Impact on the quiescent leukocytes",
pages = "74-63",
volume = "133",
doi = "10.1016/j.rvsc.2020.09.004"
}

Kovačić, M., Fratrić, N., Arsić, A., Mojsilović, S., Drvenica, I., Marković, D., Maslovarić, I., Grujić-Milanović, J., Ivanov, M.,& Ilić, V.. (2020). Structural characteristics of circulating immune complexes in calves with bronchopneumonia: Impact on the quiescent leukocytes. in Research in Veterinary Science
Elsevier Sci Ltd, Oxford., 133, 63-74.
https://doi.org/10.1016/j.rvsc.2020.09.004

Kovačić M, Fratrić N, Arsić A, Mojsilović S, Drvenica I, Marković D, Maslovarić I, Grujić-Milanović J, Ivanov M, Ilić V. Structural characteristics of circulating immune complexes in calves with bronchopneumonia: Impact on the quiescent leukocytes. in Research in Veterinary Science. 2020;133:63-74.
doi:10.1016/j.rvsc.2020.09.004 .

Kovačić, Marijana, Fratrić, Natalija, Arsić, Aleksandra, Mojsilović, Slavko, Drvenica, Ivana, Marković, Dragana, Maslovarić, Irina, Grujić-Milanović, Jelica, Ivanov, Milan, Ilić, Vesna, "Structural characteristics of circulating immune complexes in calves with bronchopneumonia: Impact on the quiescent leukocytes" in Research in Veterinary Science, 133 (2020):63-74,
https://doi.org/10.1016/j.rvsc.2020.09.004 . .

TY  - JOUR
AU  - Resanović, Ivana
AU  - Gluvić, Zoran
AU  - Zarić, Božidarka
AU  - Sudar-Milovanović, Emina
AU  - Vučić, Vesna M.
AU  - Arsić, Aleksandra
AU  - Nedić, Olgica
AU  - Sunderić, Miloš
AU  - Gligorijević, Nikola
AU  - Milačić, Davorka
AU  - Isenović, Esma R.
PY  - 2020
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1042
AB  - Objective: Metabolic changes in type 1 diabetes mellitus (TIDM) impair vasodilation, and this leads to tissue hypoxia and microvascular pathology. Hyperbaric oxygen therapy (HBOT) can significantly improve the outcome of ischemic conditions in T1DM patients and reduce vascular complications. The aim of our study was to assess the effects of HBOT on plasma fatty acid (FA) composition, and expression of insulin-like growth factor binding protein 1 (IGFBP-1) in T1DM patients. Methods: Our study included 24 adult T1DM patients diagnosed with peripheral vascular complications. The patients were exposed to 10 sessions of 100% oxygen inhalation at 2.4 atmosphere absolute for 1 hour. Blood samples were collected at admission and after HBOT for measurement of metabolic parameters, FA composition and IGFBP-1. Measurement of plasma FA composition was determined by gas chromatography. Expression of IGFBP-1 in the serum was estimated by Western blot analysis. Results: HBOT decreased blood levels of total cholesterol (p lt 0.05), triglycerides (p lt 0.05) and low-density lipoprotein (p lt 0.05). HBOT increased plasma levels of individual FAs: palmitic acid (p lt 0.05), palmitoleic acid (p lt 0.05), docosapentaenoic acid (p lt 0.05) and docosahexaenoic acid (p lt 0.01), and decreased levels of stearic acid (p lt 0.05), alpha linolenic acid (p lt 0.05) and linoleic acid (p lt 0.01). Expression of IGFBP-1 (p lt 0.01) was increased, whereas the level of insulin (p lt 0.001) was decreased in the serum after HBOT. Conclusions: Our results indicate that HBOT exerts beneficial effects in TIDM patients by improving the lipid profile and altering FA composition.
PB  - Elsevier, Amsterdam
T2  - Canadian Journal of Diabetes
T1  - Effect of Hyperbaric Oxygen Therapy on Fatty Acid Composition and Insulin-like Growth Factor Binding Protein 1 in Adult Type 1 Diabetes Mellitus Patients: A Pilot Study
EP  - 29
IS  - 1
SP  - 22
VL  - 44
DO  - 10.1016/j.jcjd.2019.04.018
ER  - 

@article{
author = "Resanović, Ivana and Gluvić, Zoran and Zarić, Božidarka and Sudar-Milovanović, Emina and Vučić, Vesna M. and Arsić, Aleksandra and Nedić, Olgica and Sunderić, Miloš and Gligorijević, Nikola and Milačić, Davorka and Isenović, Esma R.",
year = "2020",
abstract = "Objective: Metabolic changes in type 1 diabetes mellitus (TIDM) impair vasodilation, and this leads to tissue hypoxia and microvascular pathology. Hyperbaric oxygen therapy (HBOT) can significantly improve the outcome of ischemic conditions in T1DM patients and reduce vascular complications. The aim of our study was to assess the effects of HBOT on plasma fatty acid (FA) composition, and expression of insulin-like growth factor binding protein 1 (IGFBP-1) in T1DM patients. Methods: Our study included 24 adult T1DM patients diagnosed with peripheral vascular complications. The patients were exposed to 10 sessions of 100% oxygen inhalation at 2.4 atmosphere absolute for 1 hour. Blood samples were collected at admission and after HBOT for measurement of metabolic parameters, FA composition and IGFBP-1. Measurement of plasma FA composition was determined by gas chromatography. Expression of IGFBP-1 in the serum was estimated by Western blot analysis. Results: HBOT decreased blood levels of total cholesterol (p lt 0.05), triglycerides (p lt 0.05) and low-density lipoprotein (p lt 0.05). HBOT increased plasma levels of individual FAs: palmitic acid (p lt 0.05), palmitoleic acid (p lt 0.05), docosapentaenoic acid (p lt 0.05) and docosahexaenoic acid (p lt 0.01), and decreased levels of stearic acid (p lt 0.05), alpha linolenic acid (p lt 0.05) and linoleic acid (p lt 0.01). Expression of IGFBP-1 (p lt 0.01) was increased, whereas the level of insulin (p lt 0.001) was decreased in the serum after HBOT. Conclusions: Our results indicate that HBOT exerts beneficial effects in TIDM patients by improving the lipid profile and altering FA composition.",
publisher = "Elsevier, Amsterdam",
journal = "Canadian Journal of Diabetes",
title = "Effect of Hyperbaric Oxygen Therapy on Fatty Acid Composition and Insulin-like Growth Factor Binding Protein 1 in Adult Type 1 Diabetes Mellitus Patients: A Pilot Study",
pages = "29-22",
number = "1",
volume = "44",
doi = "10.1016/j.jcjd.2019.04.018"
}

Resanović, I., Gluvić, Z., Zarić, B., Sudar-Milovanović, E., Vučić, V. M., Arsić, A., Nedić, O., Sunderić, M., Gligorijević, N., Milačić, D.,& Isenović, E. R.. (2020). Effect of Hyperbaric Oxygen Therapy on Fatty Acid Composition and Insulin-like Growth Factor Binding Protein 1 in Adult Type 1 Diabetes Mellitus Patients: A Pilot Study. in Canadian Journal of Diabetes
Elsevier, Amsterdam., 44(1), 22-29.
https://doi.org/10.1016/j.jcjd.2019.04.018

Resanović I, Gluvić Z, Zarić B, Sudar-Milovanović E, Vučić VM, Arsić A, Nedić O, Sunderić M, Gligorijević N, Milačić D, Isenović ER. Effect of Hyperbaric Oxygen Therapy on Fatty Acid Composition and Insulin-like Growth Factor Binding Protein 1 in Adult Type 1 Diabetes Mellitus Patients: A Pilot Study. in Canadian Journal of Diabetes. 2020;44(1):22-29.
doi:10.1016/j.jcjd.2019.04.018 .

Resanović, Ivana, Gluvić, Zoran, Zarić, Božidarka, Sudar-Milovanović, Emina, Vučić, Vesna M., Arsić, Aleksandra, Nedić, Olgica, Sunderić, Miloš, Gligorijević, Nikola, Milačić, Davorka, Isenović, Esma R., "Effect of Hyperbaric Oxygen Therapy on Fatty Acid Composition and Insulin-like Growth Factor Binding Protein 1 in Adult Type 1 Diabetes Mellitus Patients: A Pilot Study" in Canadian Journal of Diabetes, 44, no. 1 (2020):22-29,
https://doi.org/10.1016/j.jcjd.2019.04.018 . .

TY  - JOUR
AU  - Petrović, Snježana
AU  - Arsić, Aleksandra
AU  - Ristić-Medić, Danijela
AU  - Cvetković, Zorica
AU  - Vučić, Vesna M.
PY  - 2020
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1014
AB  - Being characterized by progressive and severe damage in neuronal cells, neurodegenerative diseases (NDDs) are the major cause of disability and morbidity in the elderly, imposing a significant economic and social burden. As major components of the central nervous system, lipids play important roles in neural health and pathology. Disturbed lipid metabolism, particularly lipid peroxidation (LPO), is associated with the development of many NDDs, including Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS), all of which show elevated levels of LPO products and LPO-modified proteins. Thus, the inhibition of neuronal oxidation might slow the progression and reduce the severity of NDD; natural antioxidants, such as polyphenols and antioxidant vitamins, seem to be the most promising agents. Here, we summarize current literature data that were derived from human studies on the effect of natural polyphenols and vitamins A, C, and E supplementation in patients with AD, PD, and ALS. Although these compounds may reduce the severity and slow the progression of NDD, research gaps remain in antioxidants supplementation in AD, PD, and ALS patients, which indicates that further human studies applying antioxidant supplementation in different forms of NDDs are urgently needed.
PB  - MDPI, Basel
T2  - Antioxidants
T1  - Lipid Peroxidation and Antioxidant Supplementation in Neurodegenerative Diseases: A Review of Human Studies
EP  - 27
IS  - 11
SP  - 1
VL  - 9
DO  - 10.3390/antiox9111128
ER  - 

@article{
author = "Petrović, Snježana and Arsić, Aleksandra and Ristić-Medić, Danijela and Cvetković, Zorica and Vučić, Vesna M.",
year = "2020",
abstract = "Being characterized by progressive and severe damage in neuronal cells, neurodegenerative diseases (NDDs) are the major cause of disability and morbidity in the elderly, imposing a significant economic and social burden. As major components of the central nervous system, lipids play important roles in neural health and pathology. Disturbed lipid metabolism, particularly lipid peroxidation (LPO), is associated with the development of many NDDs, including Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS), all of which show elevated levels of LPO products and LPO-modified proteins. Thus, the inhibition of neuronal oxidation might slow the progression and reduce the severity of NDD; natural antioxidants, such as polyphenols and antioxidant vitamins, seem to be the most promising agents. Here, we summarize current literature data that were derived from human studies on the effect of natural polyphenols and vitamins A, C, and E supplementation in patients with AD, PD, and ALS. Although these compounds may reduce the severity and slow the progression of NDD, research gaps remain in antioxidants supplementation in AD, PD, and ALS patients, which indicates that further human studies applying antioxidant supplementation in different forms of NDDs are urgently needed.",
publisher = "MDPI, Basel",
journal = "Antioxidants",
title = "Lipid Peroxidation and Antioxidant Supplementation in Neurodegenerative Diseases: A Review of Human Studies",
pages = "27-1",
number = "11",
volume = "9",
doi = "10.3390/antiox9111128"
}

Petrović, S., Arsić, A., Ristić-Medić, D., Cvetković, Z.,& Vučić, V. M.. (2020). Lipid Peroxidation and Antioxidant Supplementation in Neurodegenerative Diseases: A Review of Human Studies. in Antioxidants
MDPI, Basel., 9(11), 1-27.
https://doi.org/10.3390/antiox9111128

Petrović S, Arsić A, Ristić-Medić D, Cvetković Z, Vučić VM. Lipid Peroxidation and Antioxidant Supplementation in Neurodegenerative Diseases: A Review of Human Studies. in Antioxidants. 2020;9(11):1-27.
doi:10.3390/antiox9111128 .

Petrović, Snježana, Arsić, Aleksandra, Ristić-Medić, Danijela, Cvetković, Zorica, Vučić, Vesna M., "Lipid Peroxidation and Antioxidant Supplementation in Neurodegenerative Diseases: A Review of Human Studies" in Antioxidants, 9, no. 11 (2020):1-27,
https://doi.org/10.3390/antiox9111128 . .

TY  - JOUR
AU  - Grabež, Milkica
AU  - Škrbić, Ranko
AU  - Stojiljković, Miloš P.
AU  - Rudić-Grujić, Vesna
AU  - Paunović, Marija P.
AU  - Arsić, Aleksandra
AU  - Petrović, Snježana
AU  - Vučić, Vesna M.
AU  - Mirjanić-Azarić, Bosa
AU  - Savikin, Katarina
AU  - Menković, Nebojša
AU  - Janković, Teodora
AU  - Vasiljević, Nada
PY  - 2020
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1033
AB  - Pomegranate peel contains high levels of various phytochemicals. We evaluated the effects of pomegranate peel extract (PoPEx) consumption on plasma lipid profile, fatty acids (FA) level and blood pressure (BP) in patients with diabetes mellitus type 2 (DMT2). Thirty-seven subjects were recruited in this double blind, placebo controlled randomized trial. The study group (n = 19) received over 8 week's capsules containing PoPEx twice a daily, while the placebo group received placebo. Treatment with PoPEx induced a significant lowering of both systolic and diastolic BP. The plasma levels of triglycerides, low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio (LDL-C/HDL-C), and HbA1c were significantly decreased, while the level of HDL-C was significantly increased, compared with placebo intake. Moreover, the PoPEX treatment significantly improved the plasma lipids fatty acids content. It is concluded that consumption of PoPEx in DMT2 subject had favourable effects on some metabolic parameters, BP, lipid profile and plasma lipid FA composition.
PB  - Elsevier, Amsterdam
T2  - Journal of Functional Foods
T1  - Beneficial effects of pomegranate peel extract on plasma lipid profile, fatty acids levels and blood pressure in patients with diabetes mellitus type-2: A randomized, double-blind, placebo-controlled study
SP  - 103692
VL  - 64
DO  - 10.1016/j.jff.2019.103692
ER  - 

@article{
author = "Grabež, Milkica and Škrbić, Ranko and Stojiljković, Miloš P. and Rudić-Grujić, Vesna and Paunović, Marija P. and Arsić, Aleksandra and Petrović, Snježana and Vučić, Vesna M. and Mirjanić-Azarić, Bosa and Savikin, Katarina and Menković, Nebojša and Janković, Teodora and Vasiljević, Nada",
year = "2020",
abstract = "Pomegranate peel contains high levels of various phytochemicals. We evaluated the effects of pomegranate peel extract (PoPEx) consumption on plasma lipid profile, fatty acids (FA) level and blood pressure (BP) in patients with diabetes mellitus type 2 (DMT2). Thirty-seven subjects were recruited in this double blind, placebo controlled randomized trial. The study group (n = 19) received over 8 week's capsules containing PoPEx twice a daily, while the placebo group received placebo. Treatment with PoPEx induced a significant lowering of both systolic and diastolic BP. The plasma levels of triglycerides, low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio (LDL-C/HDL-C), and HbA1c were significantly decreased, while the level of HDL-C was significantly increased, compared with placebo intake. Moreover, the PoPEX treatment significantly improved the plasma lipids fatty acids content. It is concluded that consumption of PoPEx in DMT2 subject had favourable effects on some metabolic parameters, BP, lipid profile and plasma lipid FA composition.",
publisher = "Elsevier, Amsterdam",
journal = "Journal of Functional Foods",
title = "Beneficial effects of pomegranate peel extract on plasma lipid profile, fatty acids levels and blood pressure in patients with diabetes mellitus type-2: A randomized, double-blind, placebo-controlled study",
pages = "103692",
volume = "64",
doi = "10.1016/j.jff.2019.103692"
}

Grabež, M., Škrbić, R., Stojiljković, M. P., Rudić-Grujić, V., Paunović, M. P., Arsić, A., Petrović, S., Vučić, V. M., Mirjanić-Azarić, B., Savikin, K., Menković, N., Janković, T.,& Vasiljević, N.. (2020). Beneficial effects of pomegranate peel extract on plasma lipid profile, fatty acids levels and blood pressure in patients with diabetes mellitus type-2: A randomized, double-blind, placebo-controlled study. in Journal of Functional Foods
Elsevier, Amsterdam., 64, 103692.
https://doi.org/10.1016/j.jff.2019.103692

Grabež M, Škrbić R, Stojiljković MP, Rudić-Grujić V, Paunović MP, Arsić A, Petrović S, Vučić VM, Mirjanić-Azarić B, Savikin K, Menković N, Janković T, Vasiljević N. Beneficial effects of pomegranate peel extract on plasma lipid profile, fatty acids levels and blood pressure in patients with diabetes mellitus type-2: A randomized, double-blind, placebo-controlled study. in Journal of Functional Foods. 2020;64:103692.
doi:10.1016/j.jff.2019.103692 .

Grabež, Milkica, Škrbić, Ranko, Stojiljković, Miloš P., Rudić-Grujić, Vesna, Paunović, Marija P., Arsić, Aleksandra, Petrović, Snježana, Vučić, Vesna M., Mirjanić-Azarić, Bosa, Savikin, Katarina, Menković, Nebojša, Janković, Teodora, Vasiljević, Nada, "Beneficial effects of pomegranate peel extract on plasma lipid profile, fatty acids levels and blood pressure in patients with diabetes mellitus type-2: A randomized, double-blind, placebo-controlled study" in Journal of Functional Foods, 64 (2020):103692,
https://doi.org/10.1016/j.jff.2019.103692 . .

TY  - JOUR
AU  - Arsić, Aleksandra
AU  - Pešić, Goran
AU  - Petrović, Snježana
AU  - Matić, Aleksandar
AU  - Jeremić, Jovana
AU  - Jakovljević, Vladimir
AU  - Vučić, Vesna M.
PY  - 2020
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1036
AB  - Our study aimed to examine the status of plasma fatty acids (FAs), inflammatory markers, and lipid peroxidation in patients with femoral neck fractures. The study included 20 patients (64-86 years) with femoral neck fractures indicated for surgery and a control group of 17 elderly subjects without fractures or serious chronic diseases. Plasma was obtained during the first 12 h postfracture and presurgery and 7 days postop. Compared to the control, patients had significantly higher saturated FA (SFA) and monounsaturated FA as well as increased TNF-alpha and IL-6. Opposite to that, levels of individual and total n-6 polyunsaturated FA (PUFA), individual and total n-3 PUFA, n-6/n-3 ratio, and levels of thiobarbituric acid reactive substances (TBARS) were markedly lower in the patient than in the controls. On the seventh day after the surgery, we showed a further rise in the SFA, oleic acid, and TNF-alpha and reductions of n-6 PUFA and IL-6. Taken together, our results suggest that altered FA status, especially reduced PUFA, may influence hip fracture repair and even contribute to femoral fracture susceptibility in the elderly. A potential benefit from nutritional intervention with PUFA in prevention and (or) fracture healing should be considered.
PB  - Canadian Science Publishing, Ottawa
T2  - Canadian Journal of Physiology & Pharmacology
T1  - Adverse plasma fatty acid composition in patients with femoral neck fracture
EP  - 66
IS  - 2
SP  - 61
VL  - 98
DO  - 10.1139/cjpp-2019-0249
ER  - 

@article{
author = "Arsić, Aleksandra and Pešić, Goran and Petrović, Snježana and Matić, Aleksandar and Jeremić, Jovana and Jakovljević, Vladimir and Vučić, Vesna M.",
year = "2020",
abstract = "Our study aimed to examine the status of plasma fatty acids (FAs), inflammatory markers, and lipid peroxidation in patients with femoral neck fractures. The study included 20 patients (64-86 years) with femoral neck fractures indicated for surgery and a control group of 17 elderly subjects without fractures or serious chronic diseases. Plasma was obtained during the first 12 h postfracture and presurgery and 7 days postop. Compared to the control, patients had significantly higher saturated FA (SFA) and monounsaturated FA as well as increased TNF-alpha and IL-6. Opposite to that, levels of individual and total n-6 polyunsaturated FA (PUFA), individual and total n-3 PUFA, n-6/n-3 ratio, and levels of thiobarbituric acid reactive substances (TBARS) were markedly lower in the patient than in the controls. On the seventh day after the surgery, we showed a further rise in the SFA, oleic acid, and TNF-alpha and reductions of n-6 PUFA and IL-6. Taken together, our results suggest that altered FA status, especially reduced PUFA, may influence hip fracture repair and even contribute to femoral fracture susceptibility in the elderly. A potential benefit from nutritional intervention with PUFA in prevention and (or) fracture healing should be considered.",
publisher = "Canadian Science Publishing, Ottawa",
journal = "Canadian Journal of Physiology & Pharmacology",
title = "Adverse plasma fatty acid composition in patients with femoral neck fracture",
pages = "66-61",
number = "2",
volume = "98",
doi = "10.1139/cjpp-2019-0249"
}

Arsić, A., Pešić, G., Petrović, S., Matić, A., Jeremić, J., Jakovljević, V.,& Vučić, V. M.. (2020). Adverse plasma fatty acid composition in patients with femoral neck fracture. in Canadian Journal of Physiology & Pharmacology
Canadian Science Publishing, Ottawa., 98(2), 61-66.
https://doi.org/10.1139/cjpp-2019-0249

Arsić A, Pešić G, Petrović S, Matić A, Jeremić J, Jakovljević V, Vučić VM. Adverse plasma fatty acid composition in patients with femoral neck fracture. in Canadian Journal of Physiology & Pharmacology. 2020;98(2):61-66.
doi:10.1139/cjpp-2019-0249 .

Arsić, Aleksandra, Pešić, Goran, Petrović, Snježana, Matić, Aleksandar, Jeremić, Jovana, Jakovljević, Vladimir, Vučić, Vesna M., "Adverse plasma fatty acid composition in patients with femoral neck fracture" in Canadian Journal of Physiology & Pharmacology, 98, no. 2 (2020):61-66,
https://doi.org/10.1139/cjpp-2019-0249 . .

TY  - JOUR
AU  - Arsić, Aleksandra
AU  - Petrović, Snježana
AU  - Čikiriz, Nikola
AU  - Ristić-Medić, Danijela
AU  - Vučić, Vesna M.
PY  - 2020
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1045
AB  - Background/Aim. Consensus on the exercise effect on the fatty acid metabolism has not been reached, and probably depends on the type of sports (aerobic, anaerobic or mixed). The aim of this study was to investigate effect of long-term handball training on the body composition, lipid profile and the plasma phospholipid fatty acid composition in female and male younger players. Methods. Seventeen female and 15 male active handball players, aged 16-20 years, who competed at the national/international level, were enrolled in the study. A control group was established from healthy, sedentary individuals (13 females and 19 males, aged 17-21 years), comparable to the athletes in terms of age, sex and body mass index. Results. In both groups of handball players a higher percentage of palmitoleic acid and alpha linolenic acid (18:3, n-3), were found and lower percentage of oleic acid and docosahexaenoic acid (22:6, n-3), when compared with corresponding control group. On the other hand, the lower level of stearic acid and estimated activity of plasma elongase was detected in female players than in sedentary women. Furthermore, higher proportion of linoleic acid (18:2, n-6), n-6 polyunsaturated fatty acids (PUFA) and total PUFA was found only in female players in comparison to the control group. Conclusion. The observed differences between handball players and sedentary individuals showed that handball training influenced lipid and fatty acid metabolism. Follow-up of these changes could indicate potential need for supplementation or nutritional intervention in young handball players.
AB  - Uvod/Cilj. Konsenzus o uticaju treniranja na metabolizam masnih kiselina nije postignut, a taj uticaj verovatno zavisi od tipa sporta - aerobno, anaerobno ili mešovito vežbanje. Cilj ove studije bio je da se ispita efekat dugotrajnog, aktivnog treniranja rukometa na telesnu kompoziciju, profil lipida i masnih kiselina fosfolipida plazme kod mlađih kategorija rukometaša oba pola. Metode. U studiju je bilo uključeno 17 devojaka i 15 mladića, starosne dobi od 16 do 20 godina koji treniraju rukomet i takmiče se na nacionalnom i internacionalnom nivou. Kontrolnu grupu činilo je 13 devojaka i 19 mladića starosti od 17 do 21 godine, koji su bili uporedivi sa sportistima po godinama, polu i indeksu telesne mase. Rezultati. Procenat palmitoleinske i alfa-linolenske kiseline (18:3, n-3) bio značajno viši, dok je procenat oleinske i dokozaheksaenske kiseline (22:6, n-3) bio značajno niži u fosfolipidima plazme kod obe grupe sportista u odnosu na kontrolnu grupu. Sa druge strane, niži nivo stearinske kiseline i procenjene aktivnosti elongaze, ali i visok nivo linolne kiseline (18:2, n-6), ukupnih n-6 masnih kiselina, kao i ukupnih polinezasićenih masnih kiselina, utvrđen je kod rukometašica u odnosu na ispitanice iz kontrolne grupe, dok u grupi muškaraca nisu utvrđene takve razlike. Zaključak. Utvrđene razlike između rukometaša i rukometašica, sa jedne strane, i kontrolne grupe, sa druge strane, ukazale su na to da treniranje rukometa utiče na metabolizam lipida i masnih kiselina. Praćenje tih promena moglo bi ukazati na moguću potrebu za suplementacijom kod mladih rukometaša i rukometašica.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Effect of long-term strenuous training on the plasma phospholipid fatty acid composition in handball players
T1  - Efekat dugotrajnog napornog vežbanja na masnokiselinski profil fosfolipida plazme kod rukometaša
EP  - 831
IS  - 8
SP  - 826
VL  - 77
DO  - 10.2298/VSP180725159A
ER  - 

@article{
author = "Arsić, Aleksandra and Petrović, Snježana and Čikiriz, Nikola and Ristić-Medić, Danijela and Vučić, Vesna M.",
year = "2020",
abstract = "Background/Aim. Consensus on the exercise effect on the fatty acid metabolism has not been reached, and probably depends on the type of sports (aerobic, anaerobic or mixed). The aim of this study was to investigate effect of long-term handball training on the body composition, lipid profile and the plasma phospholipid fatty acid composition in female and male younger players. Methods. Seventeen female and 15 male active handball players, aged 16-20 years, who competed at the national/international level, were enrolled in the study. A control group was established from healthy, sedentary individuals (13 females and 19 males, aged 17-21 years), comparable to the athletes in terms of age, sex and body mass index. Results. In both groups of handball players a higher percentage of palmitoleic acid and alpha linolenic acid (18:3, n-3), were found and lower percentage of oleic acid and docosahexaenoic acid (22:6, n-3), when compared with corresponding control group. On the other hand, the lower level of stearic acid and estimated activity of plasma elongase was detected in female players than in sedentary women. Furthermore, higher proportion of linoleic acid (18:2, n-6), n-6 polyunsaturated fatty acids (PUFA) and total PUFA was found only in female players in comparison to the control group. Conclusion. The observed differences between handball players and sedentary individuals showed that handball training influenced lipid and fatty acid metabolism. Follow-up of these changes could indicate potential need for supplementation or nutritional intervention in young handball players., Uvod/Cilj. Konsenzus o uticaju treniranja na metabolizam masnih kiselina nije postignut, a taj uticaj verovatno zavisi od tipa sporta - aerobno, anaerobno ili mešovito vežbanje. Cilj ove studije bio je da se ispita efekat dugotrajnog, aktivnog treniranja rukometa na telesnu kompoziciju, profil lipida i masnih kiselina fosfolipida plazme kod mlađih kategorija rukometaša oba pola. Metode. U studiju je bilo uključeno 17 devojaka i 15 mladića, starosne dobi od 16 do 20 godina koji treniraju rukomet i takmiče se na nacionalnom i internacionalnom nivou. Kontrolnu grupu činilo je 13 devojaka i 19 mladića starosti od 17 do 21 godine, koji su bili uporedivi sa sportistima po godinama, polu i indeksu telesne mase. Rezultati. Procenat palmitoleinske i alfa-linolenske kiseline (18:3, n-3) bio značajno viši, dok je procenat oleinske i dokozaheksaenske kiseline (22:6, n-3) bio značajno niži u fosfolipidima plazme kod obe grupe sportista u odnosu na kontrolnu grupu. Sa druge strane, niži nivo stearinske kiseline i procenjene aktivnosti elongaze, ali i visok nivo linolne kiseline (18:2, n-6), ukupnih n-6 masnih kiselina, kao i ukupnih polinezasićenih masnih kiselina, utvrđen je kod rukometašica u odnosu na ispitanice iz kontrolne grupe, dok u grupi muškaraca nisu utvrđene takve razlike. Zaključak. Utvrđene razlike između rukometaša i rukometašica, sa jedne strane, i kontrolne grupe, sa druge strane, ukazale su na to da treniranje rukometa utiče na metabolizam lipida i masnih kiselina. Praćenje tih promena moglo bi ukazati na moguću potrebu za suplementacijom kod mladih rukometaša i rukometašica.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Effect of long-term strenuous training on the plasma phospholipid fatty acid composition in handball players, Efekat dugotrajnog napornog vežbanja na masnokiselinski profil fosfolipida plazme kod rukometaša",
pages = "831-826",
number = "8",
volume = "77",
doi = "10.2298/VSP180725159A"
}

Arsić, A., Petrović, S., Čikiriz, N., Ristić-Medić, D.,& Vučić, V. M.. (2020). Effect of long-term strenuous training on the plasma phospholipid fatty acid composition in handball players. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 77(8), 826-831.
https://doi.org/10.2298/VSP180725159A

Arsić A, Petrović S, Čikiriz N, Ristić-Medić D, Vučić VM. Effect of long-term strenuous training on the plasma phospholipid fatty acid composition in handball players. in Vojnosanitetski pregled. 2020;77(8):826-831.
doi:10.2298/VSP180725159A .

Arsić, Aleksandra, Petrović, Snježana, Čikiriz, Nikola, Ristić-Medić, Danijela, Vučić, Vesna M., "Effect of long-term strenuous training on the plasma phospholipid fatty acid composition in handball players" in Vojnosanitetski pregled, 77, no. 8 (2020):826-831,
https://doi.org/10.2298/VSP180725159A . .