TY  - JOUR
AU  - Međaković, Jelena
AU  - Čivljak, Antonia
AU  - Zorčec, Tatjana
AU  - Vučić, Vesna
AU  - Ristić-Medić, Danijela
AU  - Veselinović, Aleksandra
AU  - Čivljak, Marta
AU  - Puljak, Livia
PY  - 2024
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1487
AB  - Background: Parents/caregivers of children with developmental disabilities (CDD) have a wide range of support needs and there are various interventions available. Support, challenges, and needs among parents/caregivers of CDD likely vary in different geographical settings. This study aimed to analyze the perceptions of support, challenges, and needs among parents/caregivers of CDD in Croatia, North Macedonia, and Serbia. Methods: We conducted a cross-sectional study in March-April 2023 within the Erasmus + SynergyEd project. The eligible participants were parents and caregivers of CDD in Croatia, North Macedonia, and Serbia, who filled out a modified Caregiver Needs Survey online. Results: Among 953 participants, 542 (57%) were from Croatia, 205 (21%) were from North Macedonia and 206 (22%) were from Serbia. The most common diagnosis of participants’ children was autism spectrum disorder (26%). The child most often received the first diagnosis at the median of 2 years, diagnosed by a team of professionals. More than half (58%) of children attended preschool and public school, while 22% did not attend any schooling. Additional support from the state/city/county was received by 66% of CDD. Most participants declared not participating in association/organization for family support. Participants mostly (68%) used experts who work with the child as a source of information about their child’s condition, followed by the Internet (53%). In the last 12 months, 60% of participants had difficulties with the availability of services in their area or problems getting appointments. The biggest problem in getting support was ensuring the child’s basic rights were protected. Participants stated that ensuring greater rights for CDD was the greatest need for their families. Conclusion: Parents/caregivers of CDD in Croatia, North Macedonia, and Serbia faced multiple challenges, but most of them were satisfied with the services provided to their children. Future efforts to develop policies and services related to CDD should consider the opinions of their parents/caregivers and disparities in access to services.
PB  - Springer Nature
T2  - BMC Pediatrics
T1  - Perceptions on support, challenges and needs among parents and caregivers of children with developmental disabilities in Croatia, North Macedonia and Serbia: a cross-sectional study
IS  - 1
SP  - 297
VL  - 24
DO  - 10.1186/s12887-024-04770-7
ER  - 

@article{
author = "Međaković, Jelena and Čivljak, Antonia and Zorčec, Tatjana and Vučić, Vesna and Ristić-Medić, Danijela and Veselinović, Aleksandra and Čivljak, Marta and Puljak, Livia",
year = "2024",
abstract = "Background: Parents/caregivers of children with developmental disabilities (CDD) have a wide range of support needs and there are various interventions available. Support, challenges, and needs among parents/caregivers of CDD likely vary in different geographical settings. This study aimed to analyze the perceptions of support, challenges, and needs among parents/caregivers of CDD in Croatia, North Macedonia, and Serbia. Methods: We conducted a cross-sectional study in March-April 2023 within the Erasmus + SynergyEd project. The eligible participants were parents and caregivers of CDD in Croatia, North Macedonia, and Serbia, who filled out a modified Caregiver Needs Survey online. Results: Among 953 participants, 542 (57%) were from Croatia, 205 (21%) were from North Macedonia and 206 (22%) were from Serbia. The most common diagnosis of participants’ children was autism spectrum disorder (26%). The child most often received the first diagnosis at the median of 2 years, diagnosed by a team of professionals. More than half (58%) of children attended preschool and public school, while 22% did not attend any schooling. Additional support from the state/city/county was received by 66% of CDD. Most participants declared not participating in association/organization for family support. Participants mostly (68%) used experts who work with the child as a source of information about their child’s condition, followed by the Internet (53%). In the last 12 months, 60% of participants had difficulties with the availability of services in their area or problems getting appointments. The biggest problem in getting support was ensuring the child’s basic rights were protected. Participants stated that ensuring greater rights for CDD was the greatest need for their families. Conclusion: Parents/caregivers of CDD in Croatia, North Macedonia, and Serbia faced multiple challenges, but most of them were satisfied with the services provided to their children. Future efforts to develop policies and services related to CDD should consider the opinions of their parents/caregivers and disparities in access to services.",
publisher = "Springer Nature",
journal = "BMC Pediatrics",
title = "Perceptions on support, challenges and needs among parents and caregivers of children with developmental disabilities in Croatia, North Macedonia and Serbia: a cross-sectional study",
number = "1",
pages = "297",
volume = "24",
doi = "10.1186/s12887-024-04770-7"
}

Međaković, J., Čivljak, A., Zorčec, T., Vučić, V., Ristić-Medić, D., Veselinović, A., Čivljak, M.,& Puljak, L.. (2024). Perceptions on support, challenges and needs among parents and caregivers of children with developmental disabilities in Croatia, North Macedonia and Serbia: a cross-sectional study. in BMC Pediatrics
Springer Nature., 24(1), 297.
https://doi.org/10.1186/s12887-024-04770-7

Međaković J, Čivljak A, Zorčec T, Vučić V, Ristić-Medić D, Veselinović A, Čivljak M, Puljak L. Perceptions on support, challenges and needs among parents and caregivers of children with developmental disabilities in Croatia, North Macedonia and Serbia: a cross-sectional study. in BMC Pediatrics. 2024;24(1):297.
doi:10.1186/s12887-024-04770-7 .

Međaković, Jelena, Čivljak, Antonia, Zorčec, Tatjana, Vučić, Vesna, Ristić-Medić, Danijela, Veselinović, Aleksandra, Čivljak, Marta, Puljak, Livia, "Perceptions on support, challenges and needs among parents and caregivers of children with developmental disabilities in Croatia, North Macedonia and Serbia: a cross-sectional study" in BMC Pediatrics, 24, no. 1 (2024):297,
https://doi.org/10.1186/s12887-024-04770-7 . .

TY  - JOUR
AU  - Paunović, Marija
AU  - Ristić-Medić, Danijela
AU  - Arsić, Aleksandra
AU  - Petrović, Snježana
AU  - Krstić, Predrag
AU  - Kojadinović, Milica
AU  - Vučić, Vesna
PY  - 2024
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1482
AB  - Background/Aim. Since the coronavirus disease 2019 (COVID-19) pandemic led to a strict lockdown in Serbia, the population has experienced drastic lifestyle changes. Physical distancing, self-isolation, limited availability of essential food products, and the stress related to the availability of therapy during the pandemic particularly affected the lives of vulnerable groups, such as breast cancer (BrC) patients. The aim of this study was to examine the changes in eating behaviors and physical activity of postmenopausal BrC patients on adjuvant hormonal therapy under the COVID-19 lockdown conditions. Methods. This observational retrospective pre-post cohort study included 32 women treated with aromatase inhibitors (AIs) who responded to telephone interviews using a structured questionnaire. The questionnaire aims to collect data on eating habits (intake of certain foods on a daily/weekly basis, as well as changes in the usual choice of food), intake of supplements, changes in weight, and physical activity before and during the lockdown. Results. The results showed that, due to problems in obtaining groceries, the patients cooked and consumed homemade sweets and fruit more often (47% of the respondents), while fewer (31%) consumed fresh fish. Nearly 41% of patients reported increased food intake, and 88% reported decreased physical activity, which led to an increase in body weight in as many as 47% of subjects. The intake of supplements was doubled. Conclusion. The COVID-19 lockdown with home confinement exacerbated health risks and affected dietary patterns and physical activity, which may have had a negative impact on the long-term health of BrC patients treated with AIs.
PB  - Military Medical Academy, INI
T2  - Vojnosanitetski pregled
T2  - Vojnosanitetski pregled
T1  - Eating behaviors and physical activity during the COVID-19 pandemic lockdown: Experiences of breast cancer patients on adjuvant hormonal therapy
EP  - xx
IS  - 00
SP  - xx
DO  - 10.2298/VSP231122020P
ER  - 

@article{
author = "Paunović, Marija and Ristić-Medić, Danijela and Arsić, Aleksandra and Petrović, Snježana and Krstić, Predrag and Kojadinović, Milica and Vučić, Vesna",
year = "2024",
abstract = "Background/Aim. Since the coronavirus disease 2019 (COVID-19) pandemic led to a strict lockdown in Serbia, the population has experienced drastic lifestyle changes. Physical distancing, self-isolation, limited availability of essential food products, and the stress related to the availability of therapy during the pandemic particularly affected the lives of vulnerable groups, such as breast cancer (BrC) patients. The aim of this study was to examine the changes in eating behaviors and physical activity of postmenopausal BrC patients on adjuvant hormonal therapy under the COVID-19 lockdown conditions. Methods. This observational retrospective pre-post cohort study included 32 women treated with aromatase inhibitors (AIs) who responded to telephone interviews using a structured questionnaire. The questionnaire aims to collect data on eating habits (intake of certain foods on a daily/weekly basis, as well as changes in the usual choice of food), intake of supplements, changes in weight, and physical activity before and during the lockdown. Results. The results showed that, due to problems in obtaining groceries, the patients cooked and consumed homemade sweets and fruit more often (47% of the respondents), while fewer (31%) consumed fresh fish. Nearly 41% of patients reported increased food intake, and 88% reported decreased physical activity, which led to an increase in body weight in as many as 47% of subjects. The intake of supplements was doubled. Conclusion. The COVID-19 lockdown with home confinement exacerbated health risks and affected dietary patterns and physical activity, which may have had a negative impact on the long-term health of BrC patients treated with AIs.",
publisher = "Military Medical Academy, INI",
journal = "Vojnosanitetski pregled, Vojnosanitetski pregled",
title = "Eating behaviors and physical activity during the COVID-19 pandemic lockdown: Experiences of breast cancer patients on adjuvant hormonal therapy",
pages = "xx-xx",
number = "00",
doi = "10.2298/VSP231122020P"
}

Paunović, M., Ristić-Medić, D., Arsić, A., Petrović, S., Krstić, P., Kojadinović, M.,& Vučić, V.. (2024). Eating behaviors and physical activity during the COVID-19 pandemic lockdown: Experiences of breast cancer patients on adjuvant hormonal therapy. in Vojnosanitetski pregled
Military Medical Academy, INI.(00), xx-xx.
https://doi.org/10.2298/VSP231122020P

Paunović M, Ristić-Medić D, Arsić A, Petrović S, Krstić P, Kojadinović M, Vučić V. Eating behaviors and physical activity during the COVID-19 pandemic lockdown: Experiences of breast cancer patients on adjuvant hormonal therapy. in Vojnosanitetski pregled. 2024;(00):xx-xx.
doi:10.2298/VSP231122020P .

Paunović, Marija, Ristić-Medić, Danijela, Arsić, Aleksandra, Petrović, Snježana, Krstić, Predrag, Kojadinović, Milica, Vučić, Vesna, "Eating behaviors and physical activity during the COVID-19 pandemic lockdown: Experiences of breast cancer patients on adjuvant hormonal therapy" in Vojnosanitetski pregled, no. 00 (2024):xx-xx,
https://doi.org/10.2298/VSP231122020P . .

TY  - JOUR
AU  - Tepšić-Ostojić, Vesna
AU  - Stojanović, Zvezdana
AU  - Mraović, Tatjana
AU  - Ristić-Medić, Danijela
PY  - 2024
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1469
AB  - Background/Aim. Obesity is a chronic and relapsing condition, and since recently, it has been considered a global epidemic. Current guidelines for tripartite treatment of obesity emphasize a program of lifestyle modifications such as medical nutrition therapy, aerobic exercise, and behavioral intervention. The aim of the study was to evaluate whether specific psychological factors (general attitudes and beliefs and frustration tolerance) could be predictors of successful weight loss, i.e., factors that can be further addressed as part of the integrated therapy approach. Methods. A total of 84 consecutive overweight and obese female participants who were apparently healthy and homogeneous in age, level of education, and marital or employment status were prescribed the same medical nutrition therapy protocol as a single six-month therapeutic intervention. Prior to starting the therapy, the General Attitude and Belief Scale (GABS) and the Frustration Discomfort Scale (FDS) were administered. The participants were divided into two groups: successful (group A) and unsuccessful (group B). Group A, or the successful group [with the mean body mass index (BMI) ± standard deviation (SD) of 24.1 ± 5.81 kg/m2], consisted of 40 participants who have reached the corresponding loss, i.e., they lost ≥ 10% of the starting body weight (BW). Group B, or the unsuccessful group (with the mean BMI ± SD of 28.51 ± 2.74 kg/m2), consisted of 44 participants who have not reached the corresponding loss, i.e., they lost < 10% of the starting BW. Results. Participants in group B had significantly higher scores (p < 0.05) on the GABS subscales for the Need for Approval, Need for Comfort, and Other Downing. A statistically significant difference between groups (p < 0.05) was shown for FDS subscales of Emotional Intolerance, Entitlement, and Achievement Frustration. Conclusion. Results of our study showed that participants who were unsuccessful in medical nutrition therapy had a higher degree of dysfunctional attitudes and beliefs and higher scores of frustration intolerance when compared to successful participants. The recommendation, based on our results, would be to include psychotherapeutic techniques in the integrative obesity treatment, aimed at cognitive changes and increasing frustration tolerance.
PB  - Military Medical Academy, INI
T2  - Vojnosanitetski pregled
T1  - Higher degree of dysfunctional attitudes and beliefs and higher scores of frustration intolerance in women with unsuccessful weight loss
EP  - 12
IS  - 00
SP  - 12
UR  - https://hdl.handle.net/21.15107/rcub_rimi_1469
ER  - 

@article{
author = "Tepšić-Ostojić, Vesna and Stojanović, Zvezdana and Mraović, Tatjana and Ristić-Medić, Danijela",
year = "2024",
abstract = "Background/Aim. Obesity is a chronic and relapsing condition, and since recently, it has been considered a global epidemic. Current guidelines for tripartite treatment of obesity emphasize a program of lifestyle modifications such as medical nutrition therapy, aerobic exercise, and behavioral intervention. The aim of the study was to evaluate whether specific psychological factors (general attitudes and beliefs and frustration tolerance) could be predictors of successful weight loss, i.e., factors that can be further addressed as part of the integrated therapy approach. Methods. A total of 84 consecutive overweight and obese female participants who were apparently healthy and homogeneous in age, level of education, and marital or employment status were prescribed the same medical nutrition therapy protocol as a single six-month therapeutic intervention. Prior to starting the therapy, the General Attitude and Belief Scale (GABS) and the Frustration Discomfort Scale (FDS) were administered. The participants were divided into two groups: successful (group A) and unsuccessful (group B). Group A, or the successful group [with the mean body mass index (BMI) ± standard deviation (SD) of 24.1 ± 5.81 kg/m2], consisted of 40 participants who have reached the corresponding loss, i.e., they lost ≥ 10% of the starting body weight (BW). Group B, or the unsuccessful group (with the mean BMI ± SD of 28.51 ± 2.74 kg/m2), consisted of 44 participants who have not reached the corresponding loss, i.e., they lost < 10% of the starting BW. Results. Participants in group B had significantly higher scores (p < 0.05) on the GABS subscales for the Need for Approval, Need for Comfort, and Other Downing. A statistically significant difference between groups (p < 0.05) was shown for FDS subscales of Emotional Intolerance, Entitlement, and Achievement Frustration. Conclusion. Results of our study showed that participants who were unsuccessful in medical nutrition therapy had a higher degree of dysfunctional attitudes and beliefs and higher scores of frustration intolerance when compared to successful participants. The recommendation, based on our results, would be to include psychotherapeutic techniques in the integrative obesity treatment, aimed at cognitive changes and increasing frustration tolerance.",
publisher = "Military Medical Academy, INI",
journal = "Vojnosanitetski pregled",
title = "Higher degree of dysfunctional attitudes and beliefs and higher scores of frustration intolerance in women with unsuccessful weight loss",
pages = "12-12",
number = "00",
url = "https://hdl.handle.net/21.15107/rcub_rimi_1469"
}

Tepšić-Ostojić, V., Stojanović, Z., Mraović, T.,& Ristić-Medić, D.. (2024). Higher degree of dysfunctional attitudes and beliefs and higher scores of frustration intolerance in women with unsuccessful weight loss. in Vojnosanitetski pregled
Military Medical Academy, INI.(00), 12-12.
https://hdl.handle.net/21.15107/rcub_rimi_1469

Tepšić-Ostojić V, Stojanović Z, Mraović T, Ristić-Medić D. Higher degree of dysfunctional attitudes and beliefs and higher scores of frustration intolerance in women with unsuccessful weight loss. in Vojnosanitetski pregled. 2024;(00):12-12.
https://hdl.handle.net/21.15107/rcub_rimi_1469 .

Tepšić-Ostojić, Vesna, Stojanović, Zvezdana, Mraović, Tatjana, Ristić-Medić, Danijela, "Higher degree of dysfunctional attitudes and beliefs and higher scores of frustration intolerance in women with unsuccessful weight loss" in Vojnosanitetski pregled, no. 00 (2024):12-12,
https://hdl.handle.net/21.15107/rcub_rimi_1469 .

TY  - JOUR
AU  - Vučić, Vesna M.
AU  - Ristić-Medić, Danijela
AU  - Arsić, Aleksandra
AU  - Petrović, Snježana
AU  - Paunović, Marija
AU  - Vasiljević, Nađa
AU  - Ilich, Jasminka Z.
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1308
AB  - Osteosarcopenic adiposity (OSA) syndrome denotes the confluence of bone, muscle, and adipose tissue deterioration. Being a complex entity, numerous uncertainties about OSA still exist, despite the extensive research on the topic. Our objectives were to evaluate human studies addressing dietary intake/nutritional status and the quantity/types of physical activity related to OSA. The search in PubMed, Scopus, and Web of Science databases was conducted to examine relevant articles published from inception to the end of December 2022, utilizing the MeSH strings in the search strategy. Only studies published in English and conducted in humans (≥18 years) without chronic conditions (cancers, kidney/liver disease) or pregnancy were used. Book chapters, abstracts-only, and studies in which participants did not have all three body composition components measured to identify OSA or when body composition components could not be related to the independent/exposure variables were excluded. A total of n = 1020 articles were retrieved from all three databases and eight more from the reference lists. After the exclusion of duplicates and other unsuitable articles, n = 23 studies were evaluated. Among those, eleven were from epidemiological or cross-sectional studies relating nutrients/dietary intake or nutritional status with OSA. Another four examined the relationship between serum biomarkers (vitamin D and ferritin) with OSA, while eight articles presented the results of the interventional studies with resistance training. Overall, higher protein, calcium, potassium, and vitamins D and C intakes emerged as nutrients positively modifying OSA, along with a diet higher in fruits and low-fat dairy foods. Higher serum vitamin D and ferritin were respectively positively and negatively related to OSA. Resistance training was a safe intervention yielding several beneficial outcomes for the OSA syndrome in older women.
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Nutrients
T1  - Nutrition and Physical Activity as Modulators of Osteosarcopenic Adiposity: A Scoping Review and Recommendations for Future Research
IS  - 7
SP  - 1619
VL  - 15
DO  - 10.3390/nu15071619
ER  - 

@article{
author = "Vučić, Vesna M. and Ristić-Medić, Danijela and Arsić, Aleksandra and Petrović, Snježana and Paunović, Marija and Vasiljević, Nađa and Ilich, Jasminka Z.",
year = "2023",
abstract = "Osteosarcopenic adiposity (OSA) syndrome denotes the confluence of bone, muscle, and adipose tissue deterioration. Being a complex entity, numerous uncertainties about OSA still exist, despite the extensive research on the topic. Our objectives were to evaluate human studies addressing dietary intake/nutritional status and the quantity/types of physical activity related to OSA. The search in PubMed, Scopus, and Web of Science databases was conducted to examine relevant articles published from inception to the end of December 2022, utilizing the MeSH strings in the search strategy. Only studies published in English and conducted in humans (≥18 years) without chronic conditions (cancers, kidney/liver disease) or pregnancy were used. Book chapters, abstracts-only, and studies in which participants did not have all three body composition components measured to identify OSA or when body composition components could not be related to the independent/exposure variables were excluded. A total of n = 1020 articles were retrieved from all three databases and eight more from the reference lists. After the exclusion of duplicates and other unsuitable articles, n = 23 studies were evaluated. Among those, eleven were from epidemiological or cross-sectional studies relating nutrients/dietary intake or nutritional status with OSA. Another four examined the relationship between serum biomarkers (vitamin D and ferritin) with OSA, while eight articles presented the results of the interventional studies with resistance training. Overall, higher protein, calcium, potassium, and vitamins D and C intakes emerged as nutrients positively modifying OSA, along with a diet higher in fruits and low-fat dairy foods. Higher serum vitamin D and ferritin were respectively positively and negatively related to OSA. Resistance training was a safe intervention yielding several beneficial outcomes for the OSA syndrome in older women.",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Nutrients",
title = "Nutrition and Physical Activity as Modulators of Osteosarcopenic Adiposity: A Scoping Review and Recommendations for Future Research",
number = "7",
pages = "1619",
volume = "15",
doi = "10.3390/nu15071619"
}

Vučić, V. M., Ristić-Medić, D., Arsić, A., Petrović, S., Paunović, M., Vasiljević, N.,& Ilich, J. Z.. (2023). Nutrition and Physical Activity as Modulators of Osteosarcopenic Adiposity: A Scoping Review and Recommendations for Future Research. in Nutrients
Multidisciplinary Digital Publishing Institute (MDPI)., 15(7), 1619.
https://doi.org/10.3390/nu15071619

Vučić VM, Ristić-Medić D, Arsić A, Petrović S, Paunović M, Vasiljević N, Ilich JZ. Nutrition and Physical Activity as Modulators of Osteosarcopenic Adiposity: A Scoping Review and Recommendations for Future Research. in Nutrients. 2023;15(7):1619.
doi:10.3390/nu15071619 .

Vučić, Vesna M., Ristić-Medić, Danijela, Arsić, Aleksandra, Petrović, Snježana, Paunović, Marija, Vasiljević, Nađa, Ilich, Jasminka Z., "Nutrition and Physical Activity as Modulators of Osteosarcopenic Adiposity: A Scoping Review and Recommendations for Future Research" in Nutrients, 15, no. 7 (2023):1619,
https://doi.org/10.3390/nu15071619 . .

TY  - JOUR
AU  - Paunović, Marija
AU  - Vučić, Vesna
AU  - Milošević, Maja
AU  - Ristić-Medić, Danijela
AU  - Arsić, Aleksandra
AU  - Kojadinović, Milica
AU  - Petrović, Snježana
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1417
AB  - Metabolic syndrome (MetS) is a global public health challenge and one of the main risk factors for cardiovascular diseases. Its pandemic prevalence created a demand for developing a relevant model system for deep insight into the molecular basis of MetS. Animal models, especially Wistar rats, are commonly used for that purpose. However, there are no standardized protocols in terms of the diet, strain, or age of rats used for the development of MetS. Studies have mostly used a high-fat high-fructose (HFHF) diet in Wistar rats but have reported inconsistent results; thus the main aim of this study was to examine the effects of the HFHF diet on inducing MetS in Wistar rats. We used two different sub-strains of Wistar rats – Hannover and Kyoto – of two different age groups (8 weeks and 4 months). Animals were placed on a modified diet, standard chow diet enriched with 25% fat and 20% fructose. Following 8 weeks of treatment, all groups were tested for indicators of MetS and the treatment was extended to 16 weeks for groups that developed some of the required parameters. None of the tested groups developed MetS after 16 weeks of HFHF diet, suggesting that the HFHF diet is not sufficient to develop at least three out of five (visceral obesity, high fasting glucose, high triglyceride, low HDL-cholesterol, high blood pressure) needed parameters. Based on our results, the addition of some pharmacological agents (e.g., cholic acid) is necessary for establishing a rat model system of MetS.
PB  - University of Veterinary and Pharmaceutical Sciences
T2  - Acta Veterinaria Brno
T1  - Use of high-fat high-fructose diet for a model of metabolic syndrome in Wistar rats: challenges remain
EP  - 396
IS  - 4
SP  - 389
VL  - 92
DO  - 10.2754/avb202392040389
ER  - 

@article{
author = "Paunović, Marija and Vučić, Vesna and Milošević, Maja and Ristić-Medić, Danijela and Arsić, Aleksandra and Kojadinović, Milica and Petrović, Snježana",
year = "2023",
abstract = "Metabolic syndrome (MetS) is a global public health challenge and one of the main risk factors for cardiovascular diseases. Its pandemic prevalence created a demand for developing a relevant model system for deep insight into the molecular basis of MetS. Animal models, especially Wistar rats, are commonly used for that purpose. However, there are no standardized protocols in terms of the diet, strain, or age of rats used for the development of MetS. Studies have mostly used a high-fat high-fructose (HFHF) diet in Wistar rats but have reported inconsistent results; thus the main aim of this study was to examine the effects of the HFHF diet on inducing MetS in Wistar rats. We used two different sub-strains of Wistar rats – Hannover and Kyoto – of two different age groups (8 weeks and 4 months). Animals were placed on a modified diet, standard chow diet enriched with 25% fat and 20% fructose. Following 8 weeks of treatment, all groups were tested for indicators of MetS and the treatment was extended to 16 weeks for groups that developed some of the required parameters. None of the tested groups developed MetS after 16 weeks of HFHF diet, suggesting that the HFHF diet is not sufficient to develop at least three out of five (visceral obesity, high fasting glucose, high triglyceride, low HDL-cholesterol, high blood pressure) needed parameters. Based on our results, the addition of some pharmacological agents (e.g., cholic acid) is necessary for establishing a rat model system of MetS.",
publisher = "University of Veterinary and Pharmaceutical Sciences",
journal = "Acta Veterinaria Brno",
title = "Use of high-fat high-fructose diet for a model of metabolic syndrome in Wistar rats: challenges remain",
pages = "396-389",
number = "4",
volume = "92",
doi = "10.2754/avb202392040389"
}

Paunović, M., Vučić, V., Milošević, M., Ristić-Medić, D., Arsić, A., Kojadinović, M.,& Petrović, S.. (2023). Use of high-fat high-fructose diet for a model of metabolic syndrome in Wistar rats: challenges remain. in Acta Veterinaria Brno
University of Veterinary and Pharmaceutical Sciences., 92(4), 389-396.
https://doi.org/10.2754/avb202392040389

Paunović M, Vučić V, Milošević M, Ristić-Medić D, Arsić A, Kojadinović M, Petrović S. Use of high-fat high-fructose diet for a model of metabolic syndrome in Wistar rats: challenges remain. in Acta Veterinaria Brno. 2023;92(4):389-396.
doi:10.2754/avb202392040389 .

Paunović, Marija, Vučić, Vesna, Milošević, Maja, Ristić-Medić, Danijela, Arsić, Aleksandra, Kojadinović, Milica, Petrović, Snježana, "Use of high-fat high-fructose diet for a model of metabolic syndrome in Wistar rats: challenges remain" in Acta Veterinaria Brno, 92, no. 4 (2023):389-396,
https://doi.org/10.2754/avb202392040389 . .

TY  - JOUR
AU  - Bajerska, Joanna
AU  - Skoczek-Rubińska, Aleksandra
AU  - Małczak, Lidia
AU  - Vučić, Vesna
AU  - Arsić, Aleksandra
AU  - Kojadinović, Milica
AU  - Ristić-Medić, Danijela
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1310
AB  - It is hypothesized that plasma proportion of selected fatty acids (FAs) and dietary habits are linked with the risk of cardiovascular disease (CVD) in postmenopausal women. Therefore, this study was designed to determine the association of plasma FA composition and markers of dietary habits with an atherogenic index of plasma (AIP), a predictor of CVD risk in postmenopausal women. In total, 87 postmenopausal women with an average age of 57 ± 7 years were recruited and their dietary intake, anthropometric and biochemical parameters, and FA status in total plasma lipid proportions were determined, showing that 65.5% of the participants had a high risk of CVD according to their AIP value. After adjusting for some confounders (age, body mass index, and physical activity level), the risk of CVD was only positively associated with the frequency of consumption of animal fat spreads (butter and lard) of terrestrial origin. Regarding the FA profile, CVD risk was positively associated with the percentages of vaccenic acid, dihomo-γ-linolenic acid, and monounsaturated fatty acids (MUFA; mainly n-7) in total FA, as well as the MUFA/SFA ratio in total plasma and stearoyl-CoA desaturase-16 activity (16:1/16:0 ratio). In contrast, the risk of CVD was negatively associated with percentages of α-linolenic acid, total polyunsaturated fatty acids (PUFA), and PUFA/MUFA ratio in total plasma lipid, and the estimated activity of Δ5-desaturase (20:4/20:3 n-6 ratio). These results support the current recommendations to decrease the frequency of animal fat spread intake because it is associated with a reduced CVD risk based on AIP in postmenopausal women. In accordance with these plasma percentages of ALA, vaccenic acid, dihomo-γ-linolenic acid, PUFA, PUFA/MUFA ratio, and 16:1/16:0 ratio may be important parameters in CVD risk assessment.
PB  - Elsevier
T2  - Nutrition Research
T2  - Nutrition ResearchNutrition Research
T1  - Plasma fatty acid composition and some markers of dietary habits are associated with cardiovascular disease risk determined by an atherogenic plasma index in postmenopausal women
EP  - 60
SP  - 47
VL  - 115
DO  - 10.1016/j.nutres.2023.05.008
ER  - 

@article{
author = "Bajerska, Joanna and Skoczek-Rubińska, Aleksandra and Małczak, Lidia and Vučić, Vesna and Arsić, Aleksandra and Kojadinović, Milica and Ristić-Medić, Danijela",
year = "2023",
abstract = "It is hypothesized that plasma proportion of selected fatty acids (FAs) and dietary habits are linked with the risk of cardiovascular disease (CVD) in postmenopausal women. Therefore, this study was designed to determine the association of plasma FA composition and markers of dietary habits with an atherogenic index of plasma (AIP), a predictor of CVD risk in postmenopausal women. In total, 87 postmenopausal women with an average age of 57 ± 7 years were recruited and their dietary intake, anthropometric and biochemical parameters, and FA status in total plasma lipid proportions were determined, showing that 65.5% of the participants had a high risk of CVD according to their AIP value. After adjusting for some confounders (age, body mass index, and physical activity level), the risk of CVD was only positively associated with the frequency of consumption of animal fat spreads (butter and lard) of terrestrial origin. Regarding the FA profile, CVD risk was positively associated with the percentages of vaccenic acid, dihomo-γ-linolenic acid, and monounsaturated fatty acids (MUFA; mainly n-7) in total FA, as well as the MUFA/SFA ratio in total plasma and stearoyl-CoA desaturase-16 activity (16:1/16:0 ratio). In contrast, the risk of CVD was negatively associated with percentages of α-linolenic acid, total polyunsaturated fatty acids (PUFA), and PUFA/MUFA ratio in total plasma lipid, and the estimated activity of Δ5-desaturase (20:4/20:3 n-6 ratio). These results support the current recommendations to decrease the frequency of animal fat spread intake because it is associated with a reduced CVD risk based on AIP in postmenopausal women. In accordance with these plasma percentages of ALA, vaccenic acid, dihomo-γ-linolenic acid, PUFA, PUFA/MUFA ratio, and 16:1/16:0 ratio may be important parameters in CVD risk assessment.",
publisher = "Elsevier",
journal = "Nutrition Research, Nutrition ResearchNutrition Research",
title = "Plasma fatty acid composition and some markers of dietary habits are associated with cardiovascular disease risk determined by an atherogenic plasma index in postmenopausal women",
pages = "60-47",
volume = "115",
doi = "10.1016/j.nutres.2023.05.008"
}

Bajerska, J., Skoczek-Rubińska, A., Małczak, L., Vučić, V., Arsić, A., Kojadinović, M.,& Ristić-Medić, D.. (2023). Plasma fatty acid composition and some markers of dietary habits are associated with cardiovascular disease risk determined by an atherogenic plasma index in postmenopausal women. in Nutrition Research
Elsevier., 115, 47-60.
https://doi.org/10.1016/j.nutres.2023.05.008

Bajerska J, Skoczek-Rubińska A, Małczak L, Vučić V, Arsić A, Kojadinović M, Ristić-Medić D. Plasma fatty acid composition and some markers of dietary habits are associated with cardiovascular disease risk determined by an atherogenic plasma index in postmenopausal women. in Nutrition Research. 2023;115:47-60.
doi:10.1016/j.nutres.2023.05.008 .

Bajerska, Joanna, Skoczek-Rubińska, Aleksandra, Małczak, Lidia, Vučić, Vesna, Arsić, Aleksandra, Kojadinović, Milica, Ristić-Medić, Danijela, "Plasma fatty acid composition and some markers of dietary habits are associated with cardiovascular disease risk determined by an atherogenic plasma index in postmenopausal women" in Nutrition Research, 115 (2023):47-60,
https://doi.org/10.1016/j.nutres.2023.05.008 . .

TY  - JOUR
AU  - Ristić-Medić, Danijela
AU  - Petrović, Snježana
AU  - Polak, Tomaž
AU  - Bertoncelj, Jasna
AU  - Arsić, Aleksandra
AU  - Takić, Marija
AU  - Vučić, Vesna M.
AU  - Gurinović, Mirjana
AU  - Korošec, Mojca
PY  - 2022
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1232
AB  - Objectives: Industrially produced trans fatty acid (iTFA) have adverse health effects and thus their consumption should be limited. The aim of this study was to determine and compare the iTFA content in frequently consumed food products by young adults from the Serbian and Slovenian market with supposedly elevated iTFA content in 2015. At the time of this study, there was no recommended limit of iTFA in both countries, and reduction of iTFA in foods was on voluntary basis.Methods: We determined iTFA content in food products, 19 from the Serbian and 22 from the Slovenian market, blinded and analysed in the same analytical run. Contents of fatty acids (FA) methyl esters were analysed by capillary gas chromatography with a flame ionisation detector. Heptadecanoic acid was used as internal standard. Individual FA along with TFA were expressed as percentages of total measured FA. The amount of each FA in the sample was then calculated from the response factor and the transformation factor of the FA from the FA methyl ester content.Results: Elaidic acid (C18:1t) was found as the most abundant TFA in analysed products, ranging from 0.52 g/100 g of total FA in chocolate candy up to 60.4 g/100 g in a salami from Serbian market. In Slovenian products, the values for elaidic acid were lower, 0.04-3.95 g/100 g of total FA, except in one type of wafers (24.3 g/100 g).Conclusions: The majority of analysed products from the Serbian and three from Slovenian market exceeded the recommended WHO and EU limit of 2% iTFA of total fat in foods. Samples of frequently consumed salami, wafers, tea biscuits, and snacks were identified as products with potentially higher burden of iTFA in diets of young adults in Serbia.
T2  - Central European Journal of Public Health
T2  - Central European Journal of Public Health
T1  - Trans fatty acids in frequently consumed products from Serbian and Slovenian market
EP  - 57
IS  - 1
SP  - 51
VL  - 30
DO  - 10.21101/cejph.a5928
DO  - 10.21101/cejph.a5928
ER  - 

@article{
author = "Ristić-Medić, Danijela and Petrović, Snježana and Polak, Tomaž and Bertoncelj, Jasna and Arsić, Aleksandra and Takić, Marija and Vučić, Vesna M. and Gurinović, Mirjana and Korošec, Mojca",
year = "2022",
abstract = "Objectives: Industrially produced trans fatty acid (iTFA) have adverse health effects and thus their consumption should be limited. The aim of this study was to determine and compare the iTFA content in frequently consumed food products by young adults from the Serbian and Slovenian market with supposedly elevated iTFA content in 2015. At the time of this study, there was no recommended limit of iTFA in both countries, and reduction of iTFA in foods was on voluntary basis.Methods: We determined iTFA content in food products, 19 from the Serbian and 22 from the Slovenian market, blinded and analysed in the same analytical run. Contents of fatty acids (FA) methyl esters were analysed by capillary gas chromatography with a flame ionisation detector. Heptadecanoic acid was used as internal standard. Individual FA along with TFA were expressed as percentages of total measured FA. The amount of each FA in the sample was then calculated from the response factor and the transformation factor of the FA from the FA methyl ester content.Results: Elaidic acid (C18:1t) was found as the most abundant TFA in analysed products, ranging from 0.52 g/100 g of total FA in chocolate candy up to 60.4 g/100 g in a salami from Serbian market. In Slovenian products, the values for elaidic acid were lower, 0.04-3.95 g/100 g of total FA, except in one type of wafers (24.3 g/100 g).Conclusions: The majority of analysed products from the Serbian and three from Slovenian market exceeded the recommended WHO and EU limit of 2% iTFA of total fat in foods. Samples of frequently consumed salami, wafers, tea biscuits, and snacks were identified as products with potentially higher burden of iTFA in diets of young adults in Serbia.",
journal = "Central European Journal of Public Health, Central European Journal of Public Health",
title = "Trans fatty acids in frequently consumed products from Serbian and Slovenian market",
pages = "57-51",
number = "1",
volume = "30",
doi = "10.21101/cejph.a5928, 10.21101/cejph.a5928"
}

Ristić-Medić, D., Petrović, S., Polak, T., Bertoncelj, J., Arsić, A., Takić, M., Vučić, V. M., Gurinović, M.,& Korošec, M.. (2022). Trans fatty acids in frequently consumed products from Serbian and Slovenian market. in Central European Journal of Public Health, 30(1), 51-57.
https://doi.org/10.21101/cejph.a5928

Ristić-Medić D, Petrović S, Polak T, Bertoncelj J, Arsić A, Takić M, Vučić VM, Gurinović M, Korošec M. Trans fatty acids in frequently consumed products from Serbian and Slovenian market. in Central European Journal of Public Health. 2022;30(1):51-57.
doi:10.21101/cejph.a5928 .

Ristić-Medić, Danijela, Petrović, Snježana, Polak, Tomaž, Bertoncelj, Jasna, Arsić, Aleksandra, Takić, Marija, Vučić, Vesna M., Gurinović, Mirjana, Korošec, Mojca, "Trans fatty acids in frequently consumed products from Serbian and Slovenian market" in Central European Journal of Public Health, 30, no. 1 (2022):51-57,
https://doi.org/10.21101/cejph.a5928 . .

TY  - JOUR
AU  - Ristić-Medić, Danijela
AU  - Petrović, Snježana
AU  - Takić, Marija
AU  - Vučić, Vesna
AU  - Arsić, Aleksandra
AU  - Rađen, Slavica
AU  - Glibetić, Marija
PY  - 2022
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1338
AB  - Polyunsaturated fatty acid (PUFA) dietary intake, status and serum key fatty acid
(FA) ratios may aid in cardiovascular disease-related risk assessment. The aim of this study was to investigate
the effects of lipid-lowering diet on key FA ratios in serum phospholipids and omega-3 index in
erythrocyte phospholipids in moderately hyperlipidemic subjects. The study included 41 subjects, mean
age 56±6 years. Nutritional habits were evaluated by food frequency questionnaire. Participants followed
lipid lowering diet for 12 weeks. Energy intake of omega-6 and omega-3 FA was changed from 7.6%
and 0.6% to 5.7% and 1.2%, respectively. Marked decrease in four FA ratios in serum phospholipids,
i.e., omega-6/omega-3, arachidonic acid (AA)/eicosapentaenoic acid (EPA), AA/docosahexaenoic acid
(DHA), AA/(EPA+DHA) and omega-3 index (EPA+DHA) was found in study subjects after lipid-
lowering diet. Total cholesterol/high-density lipoprotein (HDL), low-density lipoprotein (LDL)/
HDL and triacylglycerol/HDL-cholesterol ratios positively correlated with all FA ratios, and negatively
correlated with total omega-3 levels in serum phospholipids and omega-3 index in erythrocytes. Total
serum omega-3 levels showed strongest association with lipoprotein ratios and positive correlation with
homeostatic model assessment (HOMA) index. In conclusion, lipid-lowering diet resulted in decreased
serum key FA ratios, increased omega-3 levels, and improved insulin sensitivity that may lead to a lower
risk of cardiovascular disease in subjects with moderate hyperlipidemia.
PB  - Klinicka bolnica Sestre Milosrdnice
T2  - Acta clinica Croatica
T1  - Efficacy of a Lipid-Lowering Diet on Key Fatty Acid Ratios and Omega-3 Index in Hyperlipidemic Subjects
EP  - 226
IS  - 2
SP  - 220
VL  - 61
DO  - 10.20471/acc.2022.61.02.08
ER  - 

@article{
author = "Ristić-Medić, Danijela and Petrović, Snježana and Takić, Marija and Vučić, Vesna and Arsić, Aleksandra and Rađen, Slavica and Glibetić, Marija",
year = "2022",
abstract = "Polyunsaturated fatty acid (PUFA) dietary intake, status and serum key fatty acid
(FA) ratios may aid in cardiovascular disease-related risk assessment. The aim of this study was to investigate
the effects of lipid-lowering diet on key FA ratios in serum phospholipids and omega-3 index in
erythrocyte phospholipids in moderately hyperlipidemic subjects. The study included 41 subjects, mean
age 56±6 years. Nutritional habits were evaluated by food frequency questionnaire. Participants followed
lipid lowering diet for 12 weeks. Energy intake of omega-6 and omega-3 FA was changed from 7.6%
and 0.6% to 5.7% and 1.2%, respectively. Marked decrease in four FA ratios in serum phospholipids,
i.e., omega-6/omega-3, arachidonic acid (AA)/eicosapentaenoic acid (EPA), AA/docosahexaenoic acid
(DHA), AA/(EPA+DHA) and omega-3 index (EPA+DHA) was found in study subjects after lipid-
lowering diet. Total cholesterol/high-density lipoprotein (HDL), low-density lipoprotein (LDL)/
HDL and triacylglycerol/HDL-cholesterol ratios positively correlated with all FA ratios, and negatively
correlated with total omega-3 levels in serum phospholipids and omega-3 index in erythrocytes. Total
serum omega-3 levels showed strongest association with lipoprotein ratios and positive correlation with
homeostatic model assessment (HOMA) index. In conclusion, lipid-lowering diet resulted in decreased
serum key FA ratios, increased omega-3 levels, and improved insulin sensitivity that may lead to a lower
risk of cardiovascular disease in subjects with moderate hyperlipidemia.",
publisher = "Klinicka bolnica Sestre Milosrdnice",
journal = "Acta clinica Croatica",
title = "Efficacy of a Lipid-Lowering Diet on Key Fatty Acid Ratios and Omega-3 Index in Hyperlipidemic Subjects",
pages = "226-220",
number = "2",
volume = "61",
doi = "10.20471/acc.2022.61.02.08"
}

Ristić-Medić, D., Petrović, S., Takić, M., Vučić, V., Arsić, A., Rađen, S.,& Glibetić, M.. (2022). Efficacy of a Lipid-Lowering Diet on Key Fatty Acid Ratios and Omega-3 Index in Hyperlipidemic Subjects. in Acta clinica Croatica
Klinicka bolnica Sestre Milosrdnice., 61(2), 220-226.
https://doi.org/10.20471/acc.2022.61.02.08

Ristić-Medić D, Petrović S, Takić M, Vučić V, Arsić A, Rađen S, Glibetić M. Efficacy of a Lipid-Lowering Diet on Key Fatty Acid Ratios and Omega-3 Index in Hyperlipidemic Subjects. in Acta clinica Croatica. 2022;61(2):220-226.
doi:10.20471/acc.2022.61.02.08 .

Ristić-Medić, Danijela, Petrović, Snježana, Takić, Marija, Vučić, Vesna, Arsić, Aleksandra, Rađen, Slavica, Glibetić, Marija, "Efficacy of a Lipid-Lowering Diet on Key Fatty Acid Ratios and Omega-3 Index in Hyperlipidemic Subjects" in Acta clinica Croatica, 61, no. 2 (2022):220-226,
https://doi.org/10.20471/acc.2022.61.02.08 . .

TY  - JOUR
AU  - Stojsavljević, Aleksandar
AU  - Ristić-Medić, Danijela
AU  - Krstić, Đurđa
AU  - Rovčanin, Branislav
AU  - Rađen, Slavica
AU  - Terzić, Brankica
AU  - Manojlović, Dragan
PY  - 2022
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1221
AB  - The status of essential and toxic trace elements in patients with different stages of chronic kidney disease (CKD) is still unclear and not well characterized. The present study examined the circulatory levels of a wide panel of trace elements (Al, Cr, Mn, Co, Ni, Cu, Zn, As, Se, Rb, Sr, Cd, Pb, and U) in hemodialysis patients (HD group) and pre-dialysis patients with stage 3 CKD (PD group). Comparisons were made between groups of patients and healthy individuals from the control group (CG). The levels of Al, Mn, Co, Ni, Cu, As, Se, Sr, and Pb were higher, while the levels of Cr, Zn, Rb, Cd, and U were lower in HD patients than in our CG. Higher levels of Al and Se, as well as lower levels of As, Sr, Zn, Rb, and U were significant and distinguished HD from PD. Among other analyzed elements, Co, Se, and U are the only trace elements that did not distinguish PD from CG at a statistically significant level. The HD group had lower serum U levels than the PD group, and this could be a result of hemodialysis. This study also revealed that the Cu/Zn ratio could be used as a marker for early and late detection of renal failure. Marked changes of essential and toxic trace element levels in sera indicate additional pathophysiological events in CKD, which could additionally contribute to the preexisting increased morbidity of HD patients. Measurement of trace elements in HD patients should be performed routinely.
PB  - Wiley-Blackwell
T2  - Biological Trace Element Research
T1  - Circulatory Imbalance of Essential and Toxic Trace Elements in Pre-dialysis and Hemodialysis Patients
EP  - 3125
IS  - 7
SP  - 3117
VL  - 200
DO  - 10.1007/s12011-021-02940-7
ER  - 

@article{
author = "Stojsavljević, Aleksandar and Ristić-Medić, Danijela and Krstić, Đurđa and Rovčanin, Branislav and Rađen, Slavica and Terzić, Brankica and Manojlović, Dragan",
year = "2022",
abstract = "The status of essential and toxic trace elements in patients with different stages of chronic kidney disease (CKD) is still unclear and not well characterized. The present study examined the circulatory levels of a wide panel of trace elements (Al, Cr, Mn, Co, Ni, Cu, Zn, As, Se, Rb, Sr, Cd, Pb, and U) in hemodialysis patients (HD group) and pre-dialysis patients with stage 3 CKD (PD group). Comparisons were made between groups of patients and healthy individuals from the control group (CG). The levels of Al, Mn, Co, Ni, Cu, As, Se, Sr, and Pb were higher, while the levels of Cr, Zn, Rb, Cd, and U were lower in HD patients than in our CG. Higher levels of Al and Se, as well as lower levels of As, Sr, Zn, Rb, and U were significant and distinguished HD from PD. Among other analyzed elements, Co, Se, and U are the only trace elements that did not distinguish PD from CG at a statistically significant level. The HD group had lower serum U levels than the PD group, and this could be a result of hemodialysis. This study also revealed that the Cu/Zn ratio could be used as a marker for early and late detection of renal failure. Marked changes of essential and toxic trace element levels in sera indicate additional pathophysiological events in CKD, which could additionally contribute to the preexisting increased morbidity of HD patients. Measurement of trace elements in HD patients should be performed routinely.",
publisher = "Wiley-Blackwell",
journal = "Biological Trace Element Research",
title = "Circulatory Imbalance of Essential and Toxic Trace Elements in Pre-dialysis and Hemodialysis Patients",
pages = "3125-3117",
number = "7",
volume = "200",
doi = "10.1007/s12011-021-02940-7"
}

Stojsavljević, A., Ristić-Medić, D., Krstić, Đ., Rovčanin, B., Rađen, S., Terzić, B.,& Manojlović, D.. (2022). Circulatory Imbalance of Essential and Toxic Trace Elements in Pre-dialysis and Hemodialysis Patients. in Biological Trace Element Research
Wiley-Blackwell., 200(7), 3117-3125.
https://doi.org/10.1007/s12011-021-02940-7

Stojsavljević A, Ristić-Medić D, Krstić Đ, Rovčanin B, Rađen S, Terzić B, Manojlović D. Circulatory Imbalance of Essential and Toxic Trace Elements in Pre-dialysis and Hemodialysis Patients. in Biological Trace Element Research. 2022;200(7):3117-3125.
doi:10.1007/s12011-021-02940-7 .

Stojsavljević, Aleksandar, Ristić-Medić, Danijela, Krstić, Đurđa, Rovčanin, Branislav, Rađen, Slavica, Terzić, Brankica, Manojlović, Dragan, "Circulatory Imbalance of Essential and Toxic Trace Elements in Pre-dialysis and Hemodialysis Patients" in Biological Trace Element Research, 200, no. 7 (2022):3117-3125,
https://doi.org/10.1007/s12011-021-02940-7 . .

TY  - JOUR
AU  - Ristić-Medić, Danijela
AU  - Bajerska, Joanna
AU  - Vučić, Vesna M.
PY  - 2022
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1247
AB  - The prevalence of nonalcoholic fatty liver disease (NAFLD) is rising worldwide, paralleling the epidemic of obesity. The liver is a key organ for the metabolism of proteins, fats and carbohydrates. Various types of fats and carbohydrates in isocaloric diets differently influence fat accumulation in the liver parenchyma. Therefore, nutrition can manage hepatic and cardiometabolic complications of NAFLD. Even moderately reduced caloric intake, which leads to a weight loss of 5%-10% of initial body weight, is effective in improving liver steatosis and surrogate markers of liver disease status. Among dietary patterns, the Mediterranean diet mostly prevents the onset of NAFLD. Furthermore, this diet is also the most recommended for the treatment of NAFLD patients. However, clinical trials based on the dietary interventions in NAFLD patients are sparse. Since there are only a few studies examining dietary interventions in clinically advanced stages of NAFLD, such as active and fibrotic steatohepatitis, the optimal diet for patients in these stages of the disease must still be determined. In this narrative review, we aimed to critically summarize the associations between different dietary patterns, obesity and prevention/risk for NAFLD, to describe specific dietary interventions’ impacts on liver steatosis in adults with NAFLD and to provide an updated overview of dietary recommendations that clinicians potentially need to apply in their daily practice.
T2  - World Journal of Gastroenterology
T1  - Crosstalk between dietary patterns, obesity and nonalcoholic fatty liver disease
EP  - 3333
IS  - 27
SP  - 3314
VL  - 28
DO  - 10.3748/wjg.v28.i27.3314
ER  - 

@article{
author = "Ristić-Medić, Danijela and Bajerska, Joanna and Vučić, Vesna M.",
year = "2022",
abstract = "The prevalence of nonalcoholic fatty liver disease (NAFLD) is rising worldwide, paralleling the epidemic of obesity. The liver is a key organ for the metabolism of proteins, fats and carbohydrates. Various types of fats and carbohydrates in isocaloric diets differently influence fat accumulation in the liver parenchyma. Therefore, nutrition can manage hepatic and cardiometabolic complications of NAFLD. Even moderately reduced caloric intake, which leads to a weight loss of 5%-10% of initial body weight, is effective in improving liver steatosis and surrogate markers of liver disease status. Among dietary patterns, the Mediterranean diet mostly prevents the onset of NAFLD. Furthermore, this diet is also the most recommended for the treatment of NAFLD patients. However, clinical trials based on the dietary interventions in NAFLD patients are sparse. Since there are only a few studies examining dietary interventions in clinically advanced stages of NAFLD, such as active and fibrotic steatohepatitis, the optimal diet for patients in these stages of the disease must still be determined. In this narrative review, we aimed to critically summarize the associations between different dietary patterns, obesity and prevention/risk for NAFLD, to describe specific dietary interventions’ impacts on liver steatosis in adults with NAFLD and to provide an updated overview of dietary recommendations that clinicians potentially need to apply in their daily practice.",
journal = "World Journal of Gastroenterology",
title = "Crosstalk between dietary patterns, obesity and nonalcoholic fatty liver disease",
pages = "3333-3314",
number = "27",
volume = "28",
doi = "10.3748/wjg.v28.i27.3314"
}

Ristić-Medić, D., Bajerska, J.,& Vučić, V. M.. (2022). Crosstalk between dietary patterns, obesity and nonalcoholic fatty liver disease. in World Journal of Gastroenterology, 28(27), 3314-3333.
https://doi.org/10.3748/wjg.v28.i27.3314

Ristić-Medić D, Bajerska J, Vučić VM. Crosstalk between dietary patterns, obesity and nonalcoholic fatty liver disease. in World Journal of Gastroenterology. 2022;28(27):3314-3333.
doi:10.3748/wjg.v28.i27.3314 .

Ristić-Medić, Danijela, Bajerska, Joanna, Vučić, Vesna M., "Crosstalk between dietary patterns, obesity and nonalcoholic fatty liver disease" in World Journal of Gastroenterology, 28, no. 27 (2022):3314-3333,
https://doi.org/10.3748/wjg.v28.i27.3314 . .

TY  - JOUR
AU  - Nørgaard, Birgitte
AU  - Briel, Matthias
AU  - Chrysostomou, Stavri
AU  - Ristić-Medić, Danijela
AU  - Buttigieg, Sandra C.
AU  - Kiisk, Ele
AU  - Puljak, Livia
AU  - Bała, Małgorzata Maria
AU  - Peričić, Tina Poklepović
AU  - Les̈niak, Wiktoria M.
AU  - Zaja̧c, Joanna F.
AU  - Lund, Hans
AU  - Pieper, Dawid
PY  - 2022
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1250
AB  - Objectives: This systematic review aimed to identify the characteristics and application of citation analyses in evaluating the justification, design, and placement of the research results of clinical health studies in the context of earlier similar studies. Study Design and Setting: We searched MEDLINE (Ovid), Embase (Ovid), and the Cochrane Methodology Register for meta-research studies. We included meta-research studies assessing whether researchers used earlier similar studies and/or systematic reviews of such studies to inform the justification or design of a new study, whether researchers used systematic reviews to inform the interpretation of new results, and meta-research studies assessing whether redundant studies were published within a specific area. The results are presented as a narrative synthesis. Results: A total of 27 studies were included. How authors of citation analyses define their outcomes appears rather arbitrary, as does how the reference of a landmark review or adherence to reporting guidelines was expected to contribute to the initiation, justification, design, or contextualization of relevant clinical trials. Conclusion: Continued and improved efforts to promote evidence-based research are needed, including clearly defined and justified outcomes in meta-research studies to monitor the implementation of an evidence-based approach.
T2  - Journal of Clinical Epidemiology
T2  - Journal of Clinical EpidemiologyJournal of Clinical Epidemiology
T1  - A systematic review of meta-research studies finds substantial methodological heterogeneity in citation analyses to monitor evidence-based research
EP  - 141
SP  - 126
VL  - 150
DO  - 10.1016/j.jclinepi.2022.06.021
ER  - 

@article{
author = "Nørgaard, Birgitte and Briel, Matthias and Chrysostomou, Stavri and Ristić-Medić, Danijela and Buttigieg, Sandra C. and Kiisk, Ele and Puljak, Livia and Bała, Małgorzata Maria and Peričić, Tina Poklepović and Les̈niak, Wiktoria M. and Zaja̧c, Joanna F. and Lund, Hans and Pieper, Dawid",
year = "2022",
abstract = "Objectives: This systematic review aimed to identify the characteristics and application of citation analyses in evaluating the justification, design, and placement of the research results of clinical health studies in the context of earlier similar studies. Study Design and Setting: We searched MEDLINE (Ovid), Embase (Ovid), and the Cochrane Methodology Register for meta-research studies. We included meta-research studies assessing whether researchers used earlier similar studies and/or systematic reviews of such studies to inform the justification or design of a new study, whether researchers used systematic reviews to inform the interpretation of new results, and meta-research studies assessing whether redundant studies were published within a specific area. The results are presented as a narrative synthesis. Results: A total of 27 studies were included. How authors of citation analyses define their outcomes appears rather arbitrary, as does how the reference of a landmark review or adherence to reporting guidelines was expected to contribute to the initiation, justification, design, or contextualization of relevant clinical trials. Conclusion: Continued and improved efforts to promote evidence-based research are needed, including clearly defined and justified outcomes in meta-research studies to monitor the implementation of an evidence-based approach.",
journal = "Journal of Clinical Epidemiology, Journal of Clinical EpidemiologyJournal of Clinical Epidemiology",
title = "A systematic review of meta-research studies finds substantial methodological heterogeneity in citation analyses to monitor evidence-based research",
pages = "141-126",
volume = "150",
doi = "10.1016/j.jclinepi.2022.06.021"
}

Nørgaard, B., Briel, M., Chrysostomou, S., Ristić-Medić, D., Buttigieg, S. C., Kiisk, E., Puljak, L., Bała, M. M., Peričić, T. P., Les̈niak, W. M., Zaja̧c, J. F., Lund, H.,& Pieper, D.. (2022). A systematic review of meta-research studies finds substantial methodological heterogeneity in citation analyses to monitor evidence-based research. in Journal of Clinical Epidemiology, 150, 126-141.
https://doi.org/10.1016/j.jclinepi.2022.06.021

Nørgaard B, Briel M, Chrysostomou S, Ristić-Medić D, Buttigieg SC, Kiisk E, Puljak L, Bała MM, Peričić TP, Les̈niak WM, Zaja̧c JF, Lund H, Pieper D. A systematic review of meta-research studies finds substantial methodological heterogeneity in citation analyses to monitor evidence-based research. in Journal of Clinical Epidemiology. 2022;150:126-141.
doi:10.1016/j.jclinepi.2022.06.021 .

Nørgaard, Birgitte, Briel, Matthias, Chrysostomou, Stavri, Ristić-Medić, Danijela, Buttigieg, Sandra C., Kiisk, Ele, Puljak, Livia, Bała, Małgorzata Maria, Peričić, Tina Poklepović, Les̈niak, Wiktoria M., Zaja̧c, Joanna F., Lund, Hans, Pieper, Dawid, "A systematic review of meta-research studies finds substantial methodological heterogeneity in citation analyses to monitor evidence-based research" in Journal of Clinical Epidemiology, 150 (2022):126-141,
https://doi.org/10.1016/j.jclinepi.2022.06.021 . .

TY  - JOUR
AU  - Arsić, Aleksandra
AU  - Takić, Marija
AU  - Kojadinović, Milica
AU  - Petrović, Snježana
AU  - Paunović, Marija P.
AU  - Vučić, Vesna M.
AU  - Ristić-Medić, Danijela
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1070
AB  - The aim of this study was to compare dietary intake and status of polyunsaturated fatty acids (PUFA) in plasma and erythrocyte phospholipids metabolically healthy and unhealthy, and obese and nonobese persons. Metabolic health status in 171 participants was defined according to criteria for metabolic syndrome. Obese and nonobese metabolically unhealthy persons (MUHO and MUHNO) had higher energy intake of n-6 PUFA (7.82 +/- 1.03 and 7.49 +/- 0.86) and lower intake of n-3 PUFA (0.60 +/- 0.12 and 0.62 +/- 0.11) compared to obese and nonobese metabolically healthy persons (MHO and MHNO) (5.92 +/- 0.63 and 5.72 +/- 0.67; 1.20 +/- 0.07 and 1.22 +/- 0.09, respectively) and a higher n-6/n-3 PUFA ratio. The plasma level of n-6 PUFA was lower in the MUHO and MUHNO groups (38.49 +/- 3.71 and 38.53 +/- 2.19) compared to MHNO (40.90 +/- 2.43), while n-3 PUFA status was lower in obese than in nonobese persons (3.58 +/- 0.79 and 3.50 +/- 1.02 vs. 4.21 +/- 0.80 and 4.06 +/- 1.15). The MHO group had a higher eicosapentaenoic/arachidonic acid ratio and estimated desaturase (SCD16, D6D) and elongase activity in plasma phospholipids compared to MHNO. The low intake of n-3 PUFA is directly associated with metabolic risk factors. These results indicated that obesity is closely associated with low levels of n-3 PUFA in plasma phospholipids, suggesting that dietary modifications including n-3 PUFA supplementation appear to be suitable therapeutic strategy in obese persons.
PB  - Canadian Science Publishing, Ottawa
T2  - Canadian Journal of Physiology & Pharmacology
T1  - Metabolically healthy obesity: is there a link with polyunsaturated fatty acid intake and status?
EP  - 71
IS  - 1
SP  - 64
VL  - 99
DO  - 10.1139/cjpp-2020-0317
ER  - 

@article{
author = "Arsić, Aleksandra and Takić, Marija and Kojadinović, Milica and Petrović, Snježana and Paunović, Marija P. and Vučić, Vesna M. and Ristić-Medić, Danijela",
year = "2021",
abstract = "The aim of this study was to compare dietary intake and status of polyunsaturated fatty acids (PUFA) in plasma and erythrocyte phospholipids metabolically healthy and unhealthy, and obese and nonobese persons. Metabolic health status in 171 participants was defined according to criteria for metabolic syndrome. Obese and nonobese metabolically unhealthy persons (MUHO and MUHNO) had higher energy intake of n-6 PUFA (7.82 +/- 1.03 and 7.49 +/- 0.86) and lower intake of n-3 PUFA (0.60 +/- 0.12 and 0.62 +/- 0.11) compared to obese and nonobese metabolically healthy persons (MHO and MHNO) (5.92 +/- 0.63 and 5.72 +/- 0.67; 1.20 +/- 0.07 and 1.22 +/- 0.09, respectively) and a higher n-6/n-3 PUFA ratio. The plasma level of n-6 PUFA was lower in the MUHO and MUHNO groups (38.49 +/- 3.71 and 38.53 +/- 2.19) compared to MHNO (40.90 +/- 2.43), while n-3 PUFA status was lower in obese than in nonobese persons (3.58 +/- 0.79 and 3.50 +/- 1.02 vs. 4.21 +/- 0.80 and 4.06 +/- 1.15). The MHO group had a higher eicosapentaenoic/arachidonic acid ratio and estimated desaturase (SCD16, D6D) and elongase activity in plasma phospholipids compared to MHNO. The low intake of n-3 PUFA is directly associated with metabolic risk factors. These results indicated that obesity is closely associated with low levels of n-3 PUFA in plasma phospholipids, suggesting that dietary modifications including n-3 PUFA supplementation appear to be suitable therapeutic strategy in obese persons.",
publisher = "Canadian Science Publishing, Ottawa",
journal = "Canadian Journal of Physiology & Pharmacology",
title = "Metabolically healthy obesity: is there a link with polyunsaturated fatty acid intake and status?",
pages = "71-64",
number = "1",
volume = "99",
doi = "10.1139/cjpp-2020-0317"
}

Arsić, A., Takić, M., Kojadinović, M., Petrović, S., Paunović, M. P., Vučić, V. M.,& Ristić-Medić, D.. (2021). Metabolically healthy obesity: is there a link with polyunsaturated fatty acid intake and status?. in Canadian Journal of Physiology & Pharmacology
Canadian Science Publishing, Ottawa., 99(1), 64-71.
https://doi.org/10.1139/cjpp-2020-0317

Arsić A, Takić M, Kojadinović M, Petrović S, Paunović MP, Vučić VM, Ristić-Medić D. Metabolically healthy obesity: is there a link with polyunsaturated fatty acid intake and status?. in Canadian Journal of Physiology & Pharmacology. 2021;99(1):64-71.
doi:10.1139/cjpp-2020-0317 .

Arsić, Aleksandra, Takić, Marija, Kojadinović, Milica, Petrović, Snježana, Paunović, Marija P., Vučić, Vesna M., Ristić-Medić, Danijela, "Metabolically healthy obesity: is there a link with polyunsaturated fatty acid intake and status?" in Canadian Journal of Physiology & Pharmacology, 99, no. 1 (2021):64-71,
https://doi.org/10.1139/cjpp-2020-0317 . .

TY  - JOUR
AU  - Ristić-Medić, Danijela
AU  - Kovačić, Marijana
AU  - Takić, Marija
AU  - Arsić, Aleksandra
AU  - Petrović, Snježana
AU  - Paunović, Marija P.
AU  - Jovicić, Maja
AU  - Vučić, Vesna M.
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1071
AB  - Lifestyle modifications are the main support of nonalcoholic fatty liver disease (NAFLD) therapy. Weight loss is one of the primary goals in NAFLD, but the effects of different calorie-restricted diets remain unclear. Thus, we evaluated the effects of two calorie-restricted diets-the Mediterranean diet (Med diet) and low-fat diet-on liver status, cardiometabolic markers, and fatty acid profiles in patients with NAFLD. Twenty-four overweight/moderately obese men were randomly assigned to consume one of these diets. Lipid levels, glucose, insulin, liver enzymes, steatosis, and fatty acid profiles of serum and erythrocytes phospholipids were assessed. After 3 months, all participants had a significant weight loss ( gt 9%), with improvements in waist circumference, body fat %, index of visceral adiposity (VAI), lipid accumulation product, fatty liver (FLI), and hepatic steatosis (HSI) index (p  lt  0.001). Both diets significantly lowered triglycerides, total and LDL-cholesterol, liver enzymes, fasting glucose, insulin, and HOMA-IR index. Fatty acid profiles were enhanced after both diets, with a significantly decreased n-6/n-3 ratio. Participants on the Med diet had higher levels of HDL-cholesterol and monounsaturated and n-3 docosahexaenoic acids in serum phospholipids and lower levels of saturated fatty acids, triglycerides, TG/HDL ratio, and FLI when compared to participants on the low-fat diet. Our results indicate that dietary patterns and calorie restriction represent central therapeutic issues in the improvement of obesity-related cardiometabolic alterations that are involved in the mechanism of hepatic steatosis. The Med diet may contribute to disease treatment even more than the low-fat diet since it leads to decreased saturated and increased monounsaturated and n-3 polyunsaturated fatty acid status and improved FLI in NAFLD patients.
PB  - MDPI
T2  - Nutrients
T1  - Calorie-Restricted Mediterranean and Low-Fat Diets Affect Fatty Acid Status in Individuals with Nonalcoholic Fatty Liver Disease
IS  - 1
SP  - 15
VL  - 13
DO  - 10.3390/nu13010015
ER  - 

@article{
author = "Ristić-Medić, Danijela and Kovačić, Marijana and Takić, Marija and Arsić, Aleksandra and Petrović, Snježana and Paunović, Marija P. and Jovicić, Maja and Vučić, Vesna M.",
year = "2021",
abstract = "Lifestyle modifications are the main support of nonalcoholic fatty liver disease (NAFLD) therapy. Weight loss is one of the primary goals in NAFLD, but the effects of different calorie-restricted diets remain unclear. Thus, we evaluated the effects of two calorie-restricted diets-the Mediterranean diet (Med diet) and low-fat diet-on liver status, cardiometabolic markers, and fatty acid profiles in patients with NAFLD. Twenty-four overweight/moderately obese men were randomly assigned to consume one of these diets. Lipid levels, glucose, insulin, liver enzymes, steatosis, and fatty acid profiles of serum and erythrocytes phospholipids were assessed. After 3 months, all participants had a significant weight loss ( gt 9%), with improvements in waist circumference, body fat %, index of visceral adiposity (VAI), lipid accumulation product, fatty liver (FLI), and hepatic steatosis (HSI) index (p  lt  0.001). Both diets significantly lowered triglycerides, total and LDL-cholesterol, liver enzymes, fasting glucose, insulin, and HOMA-IR index. Fatty acid profiles were enhanced after both diets, with a significantly decreased n-6/n-3 ratio. Participants on the Med diet had higher levels of HDL-cholesterol and monounsaturated and n-3 docosahexaenoic acids in serum phospholipids and lower levels of saturated fatty acids, triglycerides, TG/HDL ratio, and FLI when compared to participants on the low-fat diet. Our results indicate that dietary patterns and calorie restriction represent central therapeutic issues in the improvement of obesity-related cardiometabolic alterations that are involved in the mechanism of hepatic steatosis. The Med diet may contribute to disease treatment even more than the low-fat diet since it leads to decreased saturated and increased monounsaturated and n-3 polyunsaturated fatty acid status and improved FLI in NAFLD patients.",
publisher = "MDPI",
journal = "Nutrients",
title = "Calorie-Restricted Mediterranean and Low-Fat Diets Affect Fatty Acid Status in Individuals with Nonalcoholic Fatty Liver Disease",
number = "1",
pages = "15",
volume = "13",
doi = "10.3390/nu13010015"
}

Ristić-Medić, D., Kovačić, M., Takić, M., Arsić, A., Petrović, S., Paunović, M. P., Jovicić, M.,& Vučić, V. M.. (2021). Calorie-Restricted Mediterranean and Low-Fat Diets Affect Fatty Acid Status in Individuals with Nonalcoholic Fatty Liver Disease. in Nutrients
MDPI., 13(1), 15.
https://doi.org/10.3390/nu13010015

Ristić-Medić D, Kovačić M, Takić M, Arsić A, Petrović S, Paunović MP, Jovicić M, Vučić VM. Calorie-Restricted Mediterranean and Low-Fat Diets Affect Fatty Acid Status in Individuals with Nonalcoholic Fatty Liver Disease. in Nutrients. 2021;13(1):15.
doi:10.3390/nu13010015 .

Ristić-Medić, Danijela, Kovačić, Marijana, Takić, Marija, Arsić, Aleksandra, Petrović, Snježana, Paunović, Marija P., Jovicić, Maja, Vučić, Vesna M., "Calorie-Restricted Mediterranean and Low-Fat Diets Affect Fatty Acid Status in Individuals with Nonalcoholic Fatty Liver Disease" in Nutrients, 13, no. 1 (2021):15,
https://doi.org/10.3390/nu13010015 . .

TY  - JOUR
AU  - Ristić-Medić, Danijela
AU  - Petrović, Snježana
AU  - Arsić, Aleksandra
AU  - Vučić, Vesna M.
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1166
AB  - Varying degrees of liver injuries have been reported in patients infected with the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). In general, oxidative stress is actively involved in initiation and progression of liver damage. The liver metabolizes various compounds that produce free radicals. Maintaining the oxidative/antioxidative balance is important in coronavirus disease 2019 (COVID-19) patients. Antioxidant vitamins, essential trace elements and food compounds, such as polyphenols, appear to be promising agents, with effects in oxidative burst. Deficiency of these nutrients suppresses immune function and increases susceptibility to COVID-19. Daily micronutrient intake is necessary to support anti-inflammatory and antioxidative effects but for immune function may be higher than current recommended dietary intake. Antioxidant supplements (βcarotene, vitamin A, vitamin C, vitamin E, and selenium) could have a potential role in patients with liver damage. Available evidence suggests that supplementing the diet with a combination of micronutrients may help to optimize immune function and reduce the risk of infection. Clinical trials based on the associations of diet and SARS-CoV-2 infection are lacking. Unfortunately, it is not possible to definitively determine the dose, route of administration and best timing to intervene with antioxidants in COVID-19 patients because clinical trials are still ongoing. Until then, hopefully, this review will enable clinicians to understand the impact of micronutrient dietary intake and liver status assessment in COVID-19 patients.
PB  - Baishideng Publishing Group
T2  - World Journal of Gastroenterology
T1  - Liver disease and COVID-19: The link with oxidative stress, antioxidants and nutrition
EP  - 5699
IS  - 34
SP  - 5682
VL  - 27
DO  - 10.3748/wjg.v27.i34.5682
ER  - 

@article{
author = "Ristić-Medić, Danijela and Petrović, Snježana and Arsić, Aleksandra and Vučić, Vesna M.",
year = "2021",
abstract = "Varying degrees of liver injuries have been reported in patients infected with the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). In general, oxidative stress is actively involved in initiation and progression of liver damage. The liver metabolizes various compounds that produce free radicals. Maintaining the oxidative/antioxidative balance is important in coronavirus disease 2019 (COVID-19) patients. Antioxidant vitamins, essential trace elements and food compounds, such as polyphenols, appear to be promising agents, with effects in oxidative burst. Deficiency of these nutrients suppresses immune function and increases susceptibility to COVID-19. Daily micronutrient intake is necessary to support anti-inflammatory and antioxidative effects but for immune function may be higher than current recommended dietary intake. Antioxidant supplements (βcarotene, vitamin A, vitamin C, vitamin E, and selenium) could have a potential role in patients with liver damage. Available evidence suggests that supplementing the diet with a combination of micronutrients may help to optimize immune function and reduce the risk of infection. Clinical trials based on the associations of diet and SARS-CoV-2 infection are lacking. Unfortunately, it is not possible to definitively determine the dose, route of administration and best timing to intervene with antioxidants in COVID-19 patients because clinical trials are still ongoing. Until then, hopefully, this review will enable clinicians to understand the impact of micronutrient dietary intake and liver status assessment in COVID-19 patients.",
publisher = "Baishideng Publishing Group",
journal = "World Journal of Gastroenterology",
title = "Liver disease and COVID-19: The link with oxidative stress, antioxidants and nutrition",
pages = "5699-5682",
number = "34",
volume = "27",
doi = "10.3748/wjg.v27.i34.5682"
}

Ristić-Medić, D., Petrović, S., Arsić, A.,& Vučić, V. M.. (2021). Liver disease and COVID-19: The link with oxidative stress, antioxidants and nutrition. in World Journal of Gastroenterology
Baishideng Publishing Group., 27(34), 5682-5699.
https://doi.org/10.3748/wjg.v27.i34.5682

Ristić-Medić D, Petrović S, Arsić A, Vučić VM. Liver disease and COVID-19: The link with oxidative stress, antioxidants and nutrition. in World Journal of Gastroenterology. 2021;27(34):5682-5699.
doi:10.3748/wjg.v27.i34.5682 .

Ristić-Medić, Danijela, Petrović, Snježana, Arsić, Aleksandra, Vučić, Vesna M., "Liver disease and COVID-19: The link with oxidative stress, antioxidants and nutrition" in World Journal of Gastroenterology, 27, no. 34 (2021):5682-5699,
https://doi.org/10.3748/wjg.v27.i34.5682 . .

TY  - JOUR
AU  - Rašić, Jelena S.
AU  - Ivanović, Nevena
AU  - Anđelković, Marija S.
AU  - Nedeljković, Ivana P.
AU  - Nikolic, Ivan R.
AU  - Stojanović, Sava D.
AU  - Ristić-Medić, Danijela
AU  - Takić, Marija
AU  - Đorđević, Brizita I.
AU  - Dikić, Nenad V.
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1170
AB  - The aim of this study was to determine the ergogenic effects and the safety profile of a one-component higenamine supplement in female recreational athletes. Twelve recreational female basketball players (age 29–41 years, oxygen consumption (VO2max) > 30 ml⋅kg–1⋅min–1, with training > 5 h wk–1) were randomized either to the higenamine group, or to the placebo group for 3 weeks. In order to determine ergogenic effects and safety profile of higenamine administration, we assessed the following variables before and after 3 weeks of supplementation: anthropometric parameters, resting metabolic rate (RMR), exercise testing variables, serum free fatty acids (FFAs), blood pressure, enzyme activity, urea, lipid profile, and complete blood count. There were no differences between groups in anthropometric parameters, including basal metabolic rate (BMR), RMR and body fat [p = 0.706 (Cohen’s d 0.223), p = 0.169 (Cohen’s d 0.857), and p = 0.223 (Cohen’s d 0.750), respectively], FFAs [0.43 ± 0.03 vs. 0.54 ± 0.23, p = 0.206 (Cohen’s d 0.540)], neither significant differences in cardiopulmonary parameters after the intervention period. Furthermore, all measured outcome variables in the safety assessment were not significant, with values remaining stable during the intervention period for participants in both groups. This is the first study to document the effects and the safety profile of higenamine-based dietary supplements at a specified dose in female recreational athletes. Our data indicate that 21-day of supplementation with 75 mg higenamine would not result in improving cardiopulmonary exercise fitness and weight loss in female recreational athletes. Moreover, supplementation with 75 mg higenamine is safe and well-tolerated in younger recreational female athletes.
PB  - Frontiers Media S.A.
T2  - Frontiers in Psychology
T1  - Influence of Higenamine on Exercise Performance of Recreational Female Athletes: A Randomized Double-Blinded Placebo-Controlled Trial
SP  - 633110
VL  - 12
DO  - 10.3389/fpsyg.2021.633110
ER  - 

@article{
author = "Rašić, Jelena S. and Ivanović, Nevena and Anđelković, Marija S. and Nedeljković, Ivana P. and Nikolic, Ivan R. and Stojanović, Sava D. and Ristić-Medić, Danijela and Takić, Marija and Đorđević, Brizita I. and Dikić, Nenad V.",
year = "2021",
abstract = "The aim of this study was to determine the ergogenic effects and the safety profile of a one-component higenamine supplement in female recreational athletes. Twelve recreational female basketball players (age 29–41 years, oxygen consumption (VO2max) > 30 ml⋅kg–1⋅min–1, with training > 5 h wk–1) were randomized either to the higenamine group, or to the placebo group for 3 weeks. In order to determine ergogenic effects and safety profile of higenamine administration, we assessed the following variables before and after 3 weeks of supplementation: anthropometric parameters, resting metabolic rate (RMR), exercise testing variables, serum free fatty acids (FFAs), blood pressure, enzyme activity, urea, lipid profile, and complete blood count. There were no differences between groups in anthropometric parameters, including basal metabolic rate (BMR), RMR and body fat [p = 0.706 (Cohen’s d 0.223), p = 0.169 (Cohen’s d 0.857), and p = 0.223 (Cohen’s d 0.750), respectively], FFAs [0.43 ± 0.03 vs. 0.54 ± 0.23, p = 0.206 (Cohen’s d 0.540)], neither significant differences in cardiopulmonary parameters after the intervention period. Furthermore, all measured outcome variables in the safety assessment were not significant, with values remaining stable during the intervention period for participants in both groups. This is the first study to document the effects and the safety profile of higenamine-based dietary supplements at a specified dose in female recreational athletes. Our data indicate that 21-day of supplementation with 75 mg higenamine would not result in improving cardiopulmonary exercise fitness and weight loss in female recreational athletes. Moreover, supplementation with 75 mg higenamine is safe and well-tolerated in younger recreational female athletes.",
publisher = "Frontiers Media S.A.",
journal = "Frontiers in Psychology",
title = "Influence of Higenamine on Exercise Performance of Recreational Female Athletes: A Randomized Double-Blinded Placebo-Controlled Trial",
pages = "633110",
volume = "12",
doi = "10.3389/fpsyg.2021.633110"
}

Rašić, J. S., Ivanović, N., Anđelković, M. S., Nedeljković, I. P., Nikolic, I. R., Stojanović, S. D., Ristić-Medić, D., Takić, M., Đorđević, B. I.,& Dikić, N. V.. (2021). Influence of Higenamine on Exercise Performance of Recreational Female Athletes: A Randomized Double-Blinded Placebo-Controlled Trial. in Frontiers in Psychology
Frontiers Media S.A.., 12, 633110.
https://doi.org/10.3389/fpsyg.2021.633110

Rašić JS, Ivanović N, Anđelković MS, Nedeljković IP, Nikolic IR, Stojanović SD, Ristić-Medić D, Takić M, Đorđević BI, Dikić NV. Influence of Higenamine on Exercise Performance of Recreational Female Athletes: A Randomized Double-Blinded Placebo-Controlled Trial. in Frontiers in Psychology. 2021;12:633110.
doi:10.3389/fpsyg.2021.633110 .

Rašić, Jelena S., Ivanović, Nevena, Anđelković, Marija S., Nedeljković, Ivana P., Nikolic, Ivan R., Stojanović, Sava D., Ristić-Medić, Danijela, Takić, Marija, Đorđević, Brizita I., Dikić, Nenad V., "Influence of Higenamine on Exercise Performance of Recreational Female Athletes: A Randomized Double-Blinded Placebo-Controlled Trial" in Frontiers in Psychology, 12 (2021):633110,
https://doi.org/10.3389/fpsyg.2021.633110 . .

TY  - JOUR
AU  - Takić, Marija
AU  - Zeković, Milica
AU  - Terzić, Brankica
AU  - Stojsavljević, Aleksandar
AU  - Mijušković, Mirjana
AU  - Rađen, Slavica
AU  - Ristić-Medić, Danijela
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1200
AB  - Background: Desaturation and elongation are critical processes in endogenous metabolic fatty acid pathways. Zinc (Zn) is a cofactor for desaturases and elongases enzymes. There is limited evidence regarding the relationships between biomarkers of Zn status, nutritional intake, plasma phospholipid fatty acid profile and clinical outcomes among patients undergoing hemodialysis (HD).  Objective: To examine the relationships between dietary and serum levels of Zn and Cu/Zn ratio and to explore associations of these micronutrients with PUFA profile and estimated desaturase and elongase enzyme activities in serum phospholipids among HD patients.  Methods: This study included 40 adult patients undergoing hemodialysis treatment. Repeated 24-h recalls were applied for dietary intake assessment. Serum concentration of Zn and Cu were determined using inductively coupled plasma mass spectrometry and fatty acid composition by gas-liquid chromatography. Desaturase and elongase activities were calculated from product-precursor fatty acid ratios.  Results: Inadequate dietary Zn intake was found in 55% of HD patients. They all had serum Zn concentration below the reference value of 60 μg/dL (mean 38.8 ± 7.72 μg/dL). Adequate zinc intake was accompanied with significantly higher intake of energy, total fats, SFA, MUFA and proteins. There was no correlation between Zn serum status and Zn intake estimates. Serum Cu/Zn ratio was high, (2.76 ± 0.68), directly and significantly associated with HD period, CRP, BMI, VFA, and inversely with Kt/V, albumin, iron, and iPTH. The n-6/n-3 ratio in plasma phospholipids was elevated (12.25 ± 3.45) and patients with inadequate Zn intake had lower n-3 PUFA intake and status compared to those with adequate intake. Serum Zn concentrations were inversely correlated with linoleic/dihomo-γ-linolenic acid ratio (LA/DGLA) (p = 0.037), related to D6-desaturase activity (p = 0.033) and directly with DGLA relative abundances (p = 0.024). Cu status was inversely associated with EPA level (p = 0.03) and estimates of elongase activity (p = 0.001). Furthermore, positive relationship was found between the Cu/Zn ratio and determined elongase value (p = 0.01).  Conclusion: Findings of this study underpin the high prevalence of Zn deficiency and inadequate n-3 PUFA intake and status among subjects undergoing HD. The results obtained indicate that the assessment of Zn status should be a standard parameter of nutritional status screening in HD patients while emphasizing the importance of Cu/Zn determination. Although further research is warranted, Zn and-n-3 PUFA supplementation in HD patients might be beneficial for the prevention and attenuation of adverse health outcomes.
PB  - Frontiers Media S.A.
T2  - Frontiers in Nutrition
T1  - Zinc Deficiency, Plasma Fatty Acid Profile and Desaturase Activities in Hemodialysis Patients: Is Supplementation Necessary?
SP  - 700450
VL  - 8
UR  - https://hdl.handle.net/21.15107/rcub_rimi_1200
ER  - 

@article{
author = "Takić, Marija and Zeković, Milica and Terzić, Brankica and Stojsavljević, Aleksandar and Mijušković, Mirjana and Rađen, Slavica and Ristić-Medić, Danijela",
year = "2021",
abstract = "Background: Desaturation and elongation are critical processes in endogenous metabolic fatty acid pathways. Zinc (Zn) is a cofactor for desaturases and elongases enzymes. There is limited evidence regarding the relationships between biomarkers of Zn status, nutritional intake, plasma phospholipid fatty acid profile and clinical outcomes among patients undergoing hemodialysis (HD).  Objective: To examine the relationships between dietary and serum levels of Zn and Cu/Zn ratio and to explore associations of these micronutrients with PUFA profile and estimated desaturase and elongase enzyme activities in serum phospholipids among HD patients.  Methods: This study included 40 adult patients undergoing hemodialysis treatment. Repeated 24-h recalls were applied for dietary intake assessment. Serum concentration of Zn and Cu were determined using inductively coupled plasma mass spectrometry and fatty acid composition by gas-liquid chromatography. Desaturase and elongase activities were calculated from product-precursor fatty acid ratios.  Results: Inadequate dietary Zn intake was found in 55% of HD patients. They all had serum Zn concentration below the reference value of 60 μg/dL (mean 38.8 ± 7.72 μg/dL). Adequate zinc intake was accompanied with significantly higher intake of energy, total fats, SFA, MUFA and proteins. There was no correlation between Zn serum status and Zn intake estimates. Serum Cu/Zn ratio was high, (2.76 ± 0.68), directly and significantly associated with HD period, CRP, BMI, VFA, and inversely with Kt/V, albumin, iron, and iPTH. The n-6/n-3 ratio in plasma phospholipids was elevated (12.25 ± 3.45) and patients with inadequate Zn intake had lower n-3 PUFA intake and status compared to those with adequate intake. Serum Zn concentrations were inversely correlated with linoleic/dihomo-γ-linolenic acid ratio (LA/DGLA) (p = 0.037), related to D6-desaturase activity (p = 0.033) and directly with DGLA relative abundances (p = 0.024). Cu status was inversely associated with EPA level (p = 0.03) and estimates of elongase activity (p = 0.001). Furthermore, positive relationship was found between the Cu/Zn ratio and determined elongase value (p = 0.01).  Conclusion: Findings of this study underpin the high prevalence of Zn deficiency and inadequate n-3 PUFA intake and status among subjects undergoing HD. The results obtained indicate that the assessment of Zn status should be a standard parameter of nutritional status screening in HD patients while emphasizing the importance of Cu/Zn determination. Although further research is warranted, Zn and-n-3 PUFA supplementation in HD patients might be beneficial for the prevention and attenuation of adverse health outcomes.",
publisher = "Frontiers Media S.A.",
journal = "Frontiers in Nutrition",
title = "Zinc Deficiency, Plasma Fatty Acid Profile and Desaturase Activities in Hemodialysis Patients: Is Supplementation Necessary?",
pages = "700450",
volume = "8",
url = "https://hdl.handle.net/21.15107/rcub_rimi_1200"
}

Takić, M., Zeković, M., Terzić, B., Stojsavljević, A., Mijušković, M., Rađen, S.,& Ristić-Medić, D.. (2021). Zinc Deficiency, Plasma Fatty Acid Profile and Desaturase Activities in Hemodialysis Patients: Is Supplementation Necessary?. in Frontiers in Nutrition
Frontiers Media S.A.., 8, 700450.
https://hdl.handle.net/21.15107/rcub_rimi_1200

Takić M, Zeković M, Terzić B, Stojsavljević A, Mijušković M, Rađen S, Ristić-Medić D. Zinc Deficiency, Plasma Fatty Acid Profile and Desaturase Activities in Hemodialysis Patients: Is Supplementation Necessary?. in Frontiers in Nutrition. 2021;8:700450.
https://hdl.handle.net/21.15107/rcub_rimi_1200 .

Takić, Marija, Zeković, Milica, Terzić, Brankica, Stojsavljević, Aleksandar, Mijušković, Mirjana, Rađen, Slavica, Ristić-Medić, Danijela, "Zinc Deficiency, Plasma Fatty Acid Profile and Desaturase Activities in Hemodialysis Patients: Is Supplementation Necessary?" in Frontiers in Nutrition, 8 (2021):700450,
https://hdl.handle.net/21.15107/rcub_rimi_1200 .

TY  - JOUR
AU  - Petrović, Snježana
AU  - Arsić, Aleksandra
AU  - Ristić-Medić, Danijela
AU  - Cvetković, Zorica
AU  - Vučić, Vesna M.
PY  - 2020
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1014
AB  - Being characterized by progressive and severe damage in neuronal cells, neurodegenerative diseases (NDDs) are the major cause of disability and morbidity in the elderly, imposing a significant economic and social burden. As major components of the central nervous system, lipids play important roles in neural health and pathology. Disturbed lipid metabolism, particularly lipid peroxidation (LPO), is associated with the development of many NDDs, including Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS), all of which show elevated levels of LPO products and LPO-modified proteins. Thus, the inhibition of neuronal oxidation might slow the progression and reduce the severity of NDD; natural antioxidants, such as polyphenols and antioxidant vitamins, seem to be the most promising agents. Here, we summarize current literature data that were derived from human studies on the effect of natural polyphenols and vitamins A, C, and E supplementation in patients with AD, PD, and ALS. Although these compounds may reduce the severity and slow the progression of NDD, research gaps remain in antioxidants supplementation in AD, PD, and ALS patients, which indicates that further human studies applying antioxidant supplementation in different forms of NDDs are urgently needed.
PB  - MDPI, Basel
T2  - Antioxidants
T1  - Lipid Peroxidation and Antioxidant Supplementation in Neurodegenerative Diseases: A Review of Human Studies
EP  - 27
IS  - 11
SP  - 1
VL  - 9
DO  - 10.3390/antiox9111128
ER  - 

@article{
author = "Petrović, Snježana and Arsić, Aleksandra and Ristić-Medić, Danijela and Cvetković, Zorica and Vučić, Vesna M.",
year = "2020",
abstract = "Being characterized by progressive and severe damage in neuronal cells, neurodegenerative diseases (NDDs) are the major cause of disability and morbidity in the elderly, imposing a significant economic and social burden. As major components of the central nervous system, lipids play important roles in neural health and pathology. Disturbed lipid metabolism, particularly lipid peroxidation (LPO), is associated with the development of many NDDs, including Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS), all of which show elevated levels of LPO products and LPO-modified proteins. Thus, the inhibition of neuronal oxidation might slow the progression and reduce the severity of NDD; natural antioxidants, such as polyphenols and antioxidant vitamins, seem to be the most promising agents. Here, we summarize current literature data that were derived from human studies on the effect of natural polyphenols and vitamins A, C, and E supplementation in patients with AD, PD, and ALS. Although these compounds may reduce the severity and slow the progression of NDD, research gaps remain in antioxidants supplementation in AD, PD, and ALS patients, which indicates that further human studies applying antioxidant supplementation in different forms of NDDs are urgently needed.",
publisher = "MDPI, Basel",
journal = "Antioxidants",
title = "Lipid Peroxidation and Antioxidant Supplementation in Neurodegenerative Diseases: A Review of Human Studies",
pages = "27-1",
number = "11",
volume = "9",
doi = "10.3390/antiox9111128"
}

Petrović, S., Arsić, A., Ristić-Medić, D., Cvetković, Z.,& Vučić, V. M.. (2020). Lipid Peroxidation and Antioxidant Supplementation in Neurodegenerative Diseases: A Review of Human Studies. in Antioxidants
MDPI, Basel., 9(11), 1-27.
https://doi.org/10.3390/antiox9111128

Petrović S, Arsić A, Ristić-Medić D, Cvetković Z, Vučić VM. Lipid Peroxidation and Antioxidant Supplementation in Neurodegenerative Diseases: A Review of Human Studies. in Antioxidants. 2020;9(11):1-27.
doi:10.3390/antiox9111128 .

Petrović, Snježana, Arsić, Aleksandra, Ristić-Medić, Danijela, Cvetković, Zorica, Vučić, Vesna M., "Lipid Peroxidation and Antioxidant Supplementation in Neurodegenerative Diseases: A Review of Human Studies" in Antioxidants, 9, no. 11 (2020):1-27,
https://doi.org/10.3390/antiox9111128 . .

TY  - JOUR
AU  - Arsić, Aleksandra
AU  - Petrović, Snježana
AU  - Čikiriz, Nikola
AU  - Ristić-Medić, Danijela
AU  - Vučić, Vesna M.
PY  - 2020
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1045
AB  - Background/Aim. Consensus on the exercise effect on the fatty acid metabolism has not been reached, and probably depends on the type of sports (aerobic, anaerobic or mixed). The aim of this study was to investigate effect of long-term handball training on the body composition, lipid profile and the plasma phospholipid fatty acid composition in female and male younger players. Methods. Seventeen female and 15 male active handball players, aged 16-20 years, who competed at the national/international level, were enrolled in the study. A control group was established from healthy, sedentary individuals (13 females and 19 males, aged 17-21 years), comparable to the athletes in terms of age, sex and body mass index. Results. In both groups of handball players a higher percentage of palmitoleic acid and alpha linolenic acid (18:3, n-3), were found and lower percentage of oleic acid and docosahexaenoic acid (22:6, n-3), when compared with corresponding control group. On the other hand, the lower level of stearic acid and estimated activity of plasma elongase was detected in female players than in sedentary women. Furthermore, higher proportion of linoleic acid (18:2, n-6), n-6 polyunsaturated fatty acids (PUFA) and total PUFA was found only in female players in comparison to the control group. Conclusion. The observed differences between handball players and sedentary individuals showed that handball training influenced lipid and fatty acid metabolism. Follow-up of these changes could indicate potential need for supplementation or nutritional intervention in young handball players.
AB  - Uvod/Cilj. Konsenzus o uticaju treniranja na metabolizam masnih kiselina nije postignut, a taj uticaj verovatno zavisi od tipa sporta - aerobno, anaerobno ili mešovito vežbanje. Cilj ove studije bio je da se ispita efekat dugotrajnog, aktivnog treniranja rukometa na telesnu kompoziciju, profil lipida i masnih kiselina fosfolipida plazme kod mlađih kategorija rukometaša oba pola. Metode. U studiju je bilo uključeno 17 devojaka i 15 mladića, starosne dobi od 16 do 20 godina koji treniraju rukomet i takmiče se na nacionalnom i internacionalnom nivou. Kontrolnu grupu činilo je 13 devojaka i 19 mladića starosti od 17 do 21 godine, koji su bili uporedivi sa sportistima po godinama, polu i indeksu telesne mase. Rezultati. Procenat palmitoleinske i alfa-linolenske kiseline (18:3, n-3) bio značajno viši, dok je procenat oleinske i dokozaheksaenske kiseline (22:6, n-3) bio značajno niži u fosfolipidima plazme kod obe grupe sportista u odnosu na kontrolnu grupu. Sa druge strane, niži nivo stearinske kiseline i procenjene aktivnosti elongaze, ali i visok nivo linolne kiseline (18:2, n-6), ukupnih n-6 masnih kiselina, kao i ukupnih polinezasićenih masnih kiselina, utvrđen je kod rukometašica u odnosu na ispitanice iz kontrolne grupe, dok u grupi muškaraca nisu utvrđene takve razlike. Zaključak. Utvrđene razlike između rukometaša i rukometašica, sa jedne strane, i kontrolne grupe, sa druge strane, ukazale su na to da treniranje rukometa utiče na metabolizam lipida i masnih kiselina. Praćenje tih promena moglo bi ukazati na moguću potrebu za suplementacijom kod mladih rukometaša i rukometašica.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Effect of long-term strenuous training on the plasma phospholipid fatty acid composition in handball players
T1  - Efekat dugotrajnog napornog vežbanja na masnokiselinski profil fosfolipida plazme kod rukometaša
EP  - 831
IS  - 8
SP  - 826
VL  - 77
DO  - 10.2298/VSP180725159A
ER  - 

@article{
author = "Arsić, Aleksandra and Petrović, Snježana and Čikiriz, Nikola and Ristić-Medić, Danijela and Vučić, Vesna M.",
year = "2020",
abstract = "Background/Aim. Consensus on the exercise effect on the fatty acid metabolism has not been reached, and probably depends on the type of sports (aerobic, anaerobic or mixed). The aim of this study was to investigate effect of long-term handball training on the body composition, lipid profile and the plasma phospholipid fatty acid composition in female and male younger players. Methods. Seventeen female and 15 male active handball players, aged 16-20 years, who competed at the national/international level, were enrolled in the study. A control group was established from healthy, sedentary individuals (13 females and 19 males, aged 17-21 years), comparable to the athletes in terms of age, sex and body mass index. Results. In both groups of handball players a higher percentage of palmitoleic acid and alpha linolenic acid (18:3, n-3), were found and lower percentage of oleic acid and docosahexaenoic acid (22:6, n-3), when compared with corresponding control group. On the other hand, the lower level of stearic acid and estimated activity of plasma elongase was detected in female players than in sedentary women. Furthermore, higher proportion of linoleic acid (18:2, n-6), n-6 polyunsaturated fatty acids (PUFA) and total PUFA was found only in female players in comparison to the control group. Conclusion. The observed differences between handball players and sedentary individuals showed that handball training influenced lipid and fatty acid metabolism. Follow-up of these changes could indicate potential need for supplementation or nutritional intervention in young handball players., Uvod/Cilj. Konsenzus o uticaju treniranja na metabolizam masnih kiselina nije postignut, a taj uticaj verovatno zavisi od tipa sporta - aerobno, anaerobno ili mešovito vežbanje. Cilj ove studije bio je da se ispita efekat dugotrajnog, aktivnog treniranja rukometa na telesnu kompoziciju, profil lipida i masnih kiselina fosfolipida plazme kod mlađih kategorija rukometaša oba pola. Metode. U studiju je bilo uključeno 17 devojaka i 15 mladića, starosne dobi od 16 do 20 godina koji treniraju rukomet i takmiče se na nacionalnom i internacionalnom nivou. Kontrolnu grupu činilo je 13 devojaka i 19 mladića starosti od 17 do 21 godine, koji su bili uporedivi sa sportistima po godinama, polu i indeksu telesne mase. Rezultati. Procenat palmitoleinske i alfa-linolenske kiseline (18:3, n-3) bio značajno viši, dok je procenat oleinske i dokozaheksaenske kiseline (22:6, n-3) bio značajno niži u fosfolipidima plazme kod obe grupe sportista u odnosu na kontrolnu grupu. Sa druge strane, niži nivo stearinske kiseline i procenjene aktivnosti elongaze, ali i visok nivo linolne kiseline (18:2, n-6), ukupnih n-6 masnih kiselina, kao i ukupnih polinezasićenih masnih kiselina, utvrđen je kod rukometašica u odnosu na ispitanice iz kontrolne grupe, dok u grupi muškaraca nisu utvrđene takve razlike. Zaključak. Utvrđene razlike između rukometaša i rukometašica, sa jedne strane, i kontrolne grupe, sa druge strane, ukazale su na to da treniranje rukometa utiče na metabolizam lipida i masnih kiselina. Praćenje tih promena moglo bi ukazati na moguću potrebu za suplementacijom kod mladih rukometaša i rukometašica.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Effect of long-term strenuous training on the plasma phospholipid fatty acid composition in handball players, Efekat dugotrajnog napornog vežbanja na masnokiselinski profil fosfolipida plazme kod rukometaša",
pages = "831-826",
number = "8",
volume = "77",
doi = "10.2298/VSP180725159A"
}

Arsić, A., Petrović, S., Čikiriz, N., Ristić-Medić, D.,& Vučić, V. M.. (2020). Effect of long-term strenuous training on the plasma phospholipid fatty acid composition in handball players. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 77(8), 826-831.
https://doi.org/10.2298/VSP180725159A

Arsić A, Petrović S, Čikiriz N, Ristić-Medić D, Vučić VM. Effect of long-term strenuous training on the plasma phospholipid fatty acid composition in handball players. in Vojnosanitetski pregled. 2020;77(8):826-831.
doi:10.2298/VSP180725159A .

Arsić, Aleksandra, Petrović, Snježana, Čikiriz, Nikola, Ristić-Medić, Danijela, Vučić, Vesna M., "Effect of long-term strenuous training on the plasma phospholipid fatty acid composition in handball players" in Vojnosanitetski pregled, 77, no. 8 (2020):826-831,
https://doi.org/10.2298/VSP180725159A . .

TY  - JOUR
AU  - Nikolić-Turnić, Tamara
AU  - Arsić, Aleksandra
AU  - Vučić, Vesna M.
AU  - Petrović, Snježana
AU  - Ristić-Medić, Danijela
AU  - Živković, Vladimir
AU  - Srejović, Ivan
AU  - Jeremić, Jovana
AU  - Radonjić, Tanja
AU  - Milosavljević, Isidora
AU  - Bolevich, Sergey
AU  - Bolevich, Stefany
AU  - Đurić, Dragan
AU  - Jakovljević, Vladimir
PY  - 2019
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/967
PB  - Frontiers Media Sa, Lausanne
T2  - Frontiers in Physiology
T1  - Hydroxymethylglutaryl Coenzyme a Reductase Inhibitors Differentially Modulate Plasma Fatty Acids in Rats With Diet-Induced-Hyperhomocysteinemia: Is omega-3 Fatty Acids Supplementation Necessary?
VL  - 10
DO  - 10.3389/fphys.2019.00892
ER  - 

@article{
author = "Nikolić-Turnić, Tamara and Arsić, Aleksandra and Vučić, Vesna M. and Petrović, Snježana and Ristić-Medić, Danijela and Živković, Vladimir and Srejović, Ivan and Jeremić, Jovana and Radonjić, Tanja and Milosavljević, Isidora and Bolevich, Sergey and Bolevich, Stefany and Đurić, Dragan and Jakovljević, Vladimir",
year = "2019",
publisher = "Frontiers Media Sa, Lausanne",
journal = "Frontiers in Physiology",
title = "Hydroxymethylglutaryl Coenzyme a Reductase Inhibitors Differentially Modulate Plasma Fatty Acids in Rats With Diet-Induced-Hyperhomocysteinemia: Is omega-3 Fatty Acids Supplementation Necessary?",
volume = "10",
doi = "10.3389/fphys.2019.00892"
}

Nikolić-Turnić, T., Arsić, A., Vučić, V. M., Petrović, S., Ristić-Medić, D., Živković, V., Srejović, I., Jeremić, J., Radonjić, T., Milosavljević, I., Bolevich, S., Bolevich, S., Đurić, D.,& Jakovljević, V.. (2019). Hydroxymethylglutaryl Coenzyme a Reductase Inhibitors Differentially Modulate Plasma Fatty Acids in Rats With Diet-Induced-Hyperhomocysteinemia: Is omega-3 Fatty Acids Supplementation Necessary?. in Frontiers in Physiology
Frontiers Media Sa, Lausanne., 10.
https://doi.org/10.3389/fphys.2019.00892

Nikolić-Turnić T, Arsić A, Vučić VM, Petrović S, Ristić-Medić D, Živković V, Srejović I, Jeremić J, Radonjić T, Milosavljević I, Bolevich S, Bolevich S, Đurić D, Jakovljević V. Hydroxymethylglutaryl Coenzyme a Reductase Inhibitors Differentially Modulate Plasma Fatty Acids in Rats With Diet-Induced-Hyperhomocysteinemia: Is omega-3 Fatty Acids Supplementation Necessary?. in Frontiers in Physiology. 2019;10.
doi:10.3389/fphys.2019.00892 .

Nikolić-Turnić, Tamara, Arsić, Aleksandra, Vučić, Vesna M., Petrović, Snježana, Ristić-Medić, Danijela, Živković, Vladimir, Srejović, Ivan, Jeremić, Jovana, Radonjić, Tanja, Milosavljević, Isidora, Bolevich, Sergey, Bolevich, Stefany, Đurić, Dragan, Jakovljević, Vladimir, "Hydroxymethylglutaryl Coenzyme a Reductase Inhibitors Differentially Modulate Plasma Fatty Acids in Rats With Diet-Induced-Hyperhomocysteinemia: Is omega-3 Fatty Acids Supplementation Necessary?" in Frontiers in Physiology, 10 (2019),
https://doi.org/10.3389/fphys.2019.00892 . .

TY  - JOUR
AU  - Tepšić-Ostojić, Vesna
AU  - Ristić-Medić, Danijela
AU  - Mraović, Tatjana
AU  - Bukumirić, Zoran
AU  - Vasiljević, Nada
AU  - Latas, Milan
PY  - 2019
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/926
AB  - Background/Aim. Obesity is the chronic disease and health threatening condition. The number of obese people in the world has taken epidemic conditions. Medical nutritional therapy is the first choice in the treatment of obesity, but it is also accompanied with a great percentage of attrition and a significant weight regain. The aim of our study was to evaluate if psychiatric and specific psychological factors (impulsivity) could be the predictors of successful weight loss. Methods. A study sample consisted of 84 consecutive overweight/obesity women, 20 to 40 years old, who were willing to adhere to the medical nutrition therapy after the initial anthropometric measurements were performed. All participants received a personalized nutritional counseling and a daily diet treatment with 20% caloric restriction from estimated daily energy requirement. At the beginning of the study, the 90-item Symptom Check-list (SCL-90) and the 30-item Barratt Impulsiveness scale (BIS11) were administrated. At the end of six months of caloric restriction, the conventional diet therapy and control weight measurement, the patients were divided into two groups: the group I - 40 participants (48%) who lost ≥ 10% of their initial body weight (successful group) and the group II - 44 participants (52%) who lost  lt  10% of their initial weight (unsuccessful). Results. There were no significant differences between groups in the demographic data (age, education level, employment, marital status), baseline anthropometric measurements, and in the general psychopathology total score. Groups I and II were significantly different in the total BIS-11 score (p  lt  0.001) and in Factor II (motor impulsivity) (p  lt  0.05). Conclusion. Even though the successful and unsuccessful diet responded participants did not differ in the general psychopathology and symptom dimensions, our results pointed out impulsivity as a discriminative factor between them. The total impulsivity and Factor II (motor impulsivity) as an indicator of binge eating were higher in the unsuccessfully responding overweight/obese women on the conventional diet treatment. A focus on impulsivity in a psychotherapeutic work might lead to better outcomes in the medical nutrition therapy.
AB  - Uvod/Cilj. Gojaznost je hronično oboljenje sa značajnim nepovoljnim efektima na zdravlje, a broj gojaznih osoba u svetu dostigao je epidemijske razmere. Medicinska nutritivna terapija je terapija izbora, ali je njena uspešnost ograničena zbog značajnog procenta odustajanja, kao i ponovnog dobijanja na težini koje je prate. Cilj ove studije je bio da se proceni da li psihijatrijski i specifični psihološki faktori (impulsivnost) mogu biti pokazatelji pozitivnog ishoda lečenja. Metode. Studijom je bilo obuhvaćeno ukupno 84 predgojaznih i gojaznih žena životnog doba 20-40 godina, koje su bile motivisane za medicinsku nutritivnu terapiju. Sve ispitanice su prošle individualno savetovanje i dobile dnevni plan ishrane koji je podrazumevao kalorijsku restrikciju od 20% u odnosu na procenjene dnevne energetske potrebe. Na početku studije sprovedeno je antropometrijsko merenje i primenjene su Lista simptoma od 90 pitanja (90item Symptom Check-list) i Baratova skala impulsivnosti (Barratt Impulsiveness scale (BIS-11)). Nakon šest meseci primene kalorijski restriktivnog načina ishrane ponovljena su antropometrijska merenja. Ispitanice su podeljene u dve grupe: 40 ispitanica (48%) koje su izgubile ≥ 10% od početne telesne mase (uspešne) i 44 ispitanice (52%) koje su izgubile  lt  10% od početne telesne mase (neuspešne). Rezultati. Nije bilo značajne razlike između grupa ispitanica u odnosu na demografske karakteristike (godine života, stepen obrazovanja, zaposlenost, bračni status) i antropometrijske parametre na početku studije, kao i na skor opšte psihopatologije i dimenzije simptoma. Statistički značajna razlika između uspešnih i neuspešnih predgojaznih/gojaznih ispitanica dobijena je za ukupni BIS-11 skor (p  lt  0.001) i za Faktor II (motorna impulsivnost) (p  lt  0.05). Zaključak. Ispitanice sa ponovljenim lošim odgovorom nisu se razlikovale po opštoj psihopatologiji od onih sa uspešnim odgovorom na nutritivnu terapiju. Naši rezultati ukazuju na impulsivnost kao mogući pokazatelj ishoda lečenja. Ukupna impulsivnost i motorna impulsivnost kao indikator povremenog impulsivnog prejedanja bili su viši u grupi predgojazih/gojaznih ispitanica koje nisu postigle terapijski cilj. Psihoterapijski rad na impulsivnosti možda bi mogao doprineti boljem ishodu medicinske nutritivne terapije.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - General psychopathology and impulsivity as the pretreatment predictors of medical nutrition therapy outcome in the overweight and obese women
T1  - Opšta psihopatologija i impulsivnost kao pokazatelji potencijalnog ishoda medicinske nutritivne terapije kod predgojaznih i gojaznih žena
EP  - 1109
IS  - 11
SP  - 1103
VL  - 76
DO  - 10.2298/VSP171107184T
ER  - 

@article{
author = "Tepšić-Ostojić, Vesna and Ristić-Medić, Danijela and Mraović, Tatjana and Bukumirić, Zoran and Vasiljević, Nada and Latas, Milan",
year = "2019",
abstract = "Background/Aim. Obesity is the chronic disease and health threatening condition. The number of obese people in the world has taken epidemic conditions. Medical nutritional therapy is the first choice in the treatment of obesity, but it is also accompanied with a great percentage of attrition and a significant weight regain. The aim of our study was to evaluate if psychiatric and specific psychological factors (impulsivity) could be the predictors of successful weight loss. Methods. A study sample consisted of 84 consecutive overweight/obesity women, 20 to 40 years old, who were willing to adhere to the medical nutrition therapy after the initial anthropometric measurements were performed. All participants received a personalized nutritional counseling and a daily diet treatment with 20% caloric restriction from estimated daily energy requirement. At the beginning of the study, the 90-item Symptom Check-list (SCL-90) and the 30-item Barratt Impulsiveness scale (BIS11) were administrated. At the end of six months of caloric restriction, the conventional diet therapy and control weight measurement, the patients were divided into two groups: the group I - 40 participants (48%) who lost ≥ 10% of their initial body weight (successful group) and the group II - 44 participants (52%) who lost  lt  10% of their initial weight (unsuccessful). Results. There were no significant differences between groups in the demographic data (age, education level, employment, marital status), baseline anthropometric measurements, and in the general psychopathology total score. Groups I and II were significantly different in the total BIS-11 score (p  lt  0.001) and in Factor II (motor impulsivity) (p  lt  0.05). Conclusion. Even though the successful and unsuccessful diet responded participants did not differ in the general psychopathology and symptom dimensions, our results pointed out impulsivity as a discriminative factor between them. The total impulsivity and Factor II (motor impulsivity) as an indicator of binge eating were higher in the unsuccessfully responding overweight/obese women on the conventional diet treatment. A focus on impulsivity in a psychotherapeutic work might lead to better outcomes in the medical nutrition therapy., Uvod/Cilj. Gojaznost je hronično oboljenje sa značajnim nepovoljnim efektima na zdravlje, a broj gojaznih osoba u svetu dostigao je epidemijske razmere. Medicinska nutritivna terapija je terapija izbora, ali je njena uspešnost ograničena zbog značajnog procenta odustajanja, kao i ponovnog dobijanja na težini koje je prate. Cilj ove studije je bio da se proceni da li psihijatrijski i specifični psihološki faktori (impulsivnost) mogu biti pokazatelji pozitivnog ishoda lečenja. Metode. Studijom je bilo obuhvaćeno ukupno 84 predgojaznih i gojaznih žena životnog doba 20-40 godina, koje su bile motivisane za medicinsku nutritivnu terapiju. Sve ispitanice su prošle individualno savetovanje i dobile dnevni plan ishrane koji je podrazumevao kalorijsku restrikciju od 20% u odnosu na procenjene dnevne energetske potrebe. Na početku studije sprovedeno je antropometrijsko merenje i primenjene su Lista simptoma od 90 pitanja (90item Symptom Check-list) i Baratova skala impulsivnosti (Barratt Impulsiveness scale (BIS-11)). Nakon šest meseci primene kalorijski restriktivnog načina ishrane ponovljena su antropometrijska merenja. Ispitanice su podeljene u dve grupe: 40 ispitanica (48%) koje su izgubile ≥ 10% od početne telesne mase (uspešne) i 44 ispitanice (52%) koje su izgubile  lt  10% od početne telesne mase (neuspešne). Rezultati. Nije bilo značajne razlike između grupa ispitanica u odnosu na demografske karakteristike (godine života, stepen obrazovanja, zaposlenost, bračni status) i antropometrijske parametre na početku studije, kao i na skor opšte psihopatologije i dimenzije simptoma. Statistički značajna razlika između uspešnih i neuspešnih predgojaznih/gojaznih ispitanica dobijena je za ukupni BIS-11 skor (p  lt  0.001) i za Faktor II (motorna impulsivnost) (p  lt  0.05). Zaključak. Ispitanice sa ponovljenim lošim odgovorom nisu se razlikovale po opštoj psihopatologiji od onih sa uspešnim odgovorom na nutritivnu terapiju. Naši rezultati ukazuju na impulsivnost kao mogući pokazatelj ishoda lečenja. Ukupna impulsivnost i motorna impulsivnost kao indikator povremenog impulsivnog prejedanja bili su viši u grupi predgojazih/gojaznih ispitanica koje nisu postigle terapijski cilj. Psihoterapijski rad na impulsivnosti možda bi mogao doprineti boljem ishodu medicinske nutritivne terapije.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "General psychopathology and impulsivity as the pretreatment predictors of medical nutrition therapy outcome in the overweight and obese women, Opšta psihopatologija i impulsivnost kao pokazatelji potencijalnog ishoda medicinske nutritivne terapije kod predgojaznih i gojaznih žena",
pages = "1109-1103",
number = "11",
volume = "76",
doi = "10.2298/VSP171107184T"
}

Tepšić-Ostojić, V., Ristić-Medić, D., Mraović, T., Bukumirić, Z., Vasiljević, N.,& Latas, M.. (2019). General psychopathology and impulsivity as the pretreatment predictors of medical nutrition therapy outcome in the overweight and obese women. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 76(11), 1103-1109.
https://doi.org/10.2298/VSP171107184T

Tepšić-Ostojić V, Ristić-Medić D, Mraović T, Bukumirić Z, Vasiljević N, Latas M. General psychopathology and impulsivity as the pretreatment predictors of medical nutrition therapy outcome in the overweight and obese women. in Vojnosanitetski pregled. 2019;76(11):1103-1109.
doi:10.2298/VSP171107184T .

Tepšić-Ostojić, Vesna, Ristić-Medić, Danijela, Mraović, Tatjana, Bukumirić, Zoran, Vasiljević, Nada, Latas, Milan, "General psychopathology and impulsivity as the pretreatment predictors of medical nutrition therapy outcome in the overweight and obese women" in Vojnosanitetski pregled, 76, no. 11 (2019):1103-1109,
https://doi.org/10.2298/VSP171107184T . .

TY  - JOUR
AU  - Dragović, Tamara
AU  - Mijušković, Mirjana
AU  - Terzić, Brankica
AU  - Ristić-Medić, Danijela
AU  - Hajduković, Zoran
AU  - Rađen, Slavica
PY  - 2019
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/937
AB  - Background/Aim. Inflammation is the most important factor in the genesis of vascular complication in the endstage renal disease. The serum C-reactive protein (CRP) level is a sensitive marker of systemic inflammation as well as a predisposing factor for cardiovascular and all cause mortality in patients on hemodialysis. Albumin is the negative acute phase protein and its synthesis declines during the inflammation. The patients undergoing hemodialysis have a high prevalence of protein-energy malnutrition, due to reduced protein synthesis and increased degradation. The low serum albumin levels in these patients originate from the complex setting of conditions with systemic inflammatory response as a major cause, malnutrition and overhydratation. The aim of this study was to determine the prevalence of elevated CRP levels in the dialysis patients and to analyse its correlation with serum albumin levels and other parameters of nutritional status. Methods. The study included 49 patients on maintenance hemodialysis at the Department of Hemodialysis, Clinic of Nephrology, Military Medical Academy, Belgrade, Serbia. In order to analyse the parameters, the blood samples were taken during the arteriovenous fistula (AVF) puncture and before the second weekly dialyse. The following parameters were determined: serum levels of urea and creatinine before and after the dialysis procedure, CRP, hemoglobin, fasting glycemia, total cholesterol, triglycerides, albumins, iron, glycosylated hemoglobin (HbA1c), fasting insulinemia and C-peptide only before the dialysis. Results. Out of 49 patients on maintenance hemodialysis, 37 (75.5%) were males and 12 (24.5%) females with the average age of 56.04 ± 13.93 years. The average duration of the dialysis treatment was 7.37 ± 5 years. The high serum CRP levels (more than 3 mg/L) was found in 65.3% of patients. Singificantly more diabetic patients were observed in the group with the higher CRP levels (n = 12) compared to the group with the normal CRP levels (n = 3) (p ≤ 0.05). A significant positive correlation was found between the CRP value and urea values after the dialysis procedure. We found negative correlation between the CRP values and serum albumin, HbA1c, total cholesterol and triglyceride levels, with no statistical significance. Conclusion. Our study observed a high rate of inflammation in the dialysis patients presenting as high frequency of the elevated CRP levels in the examined group. Negative correlation between CRP levels and serum albumin as well as with some other parameters of nutritional status, suggests that chronic inflammation may be the missing link that actually connect protein energy malnutrition with high morbiditiy and mortality rate in these patients.
AB  - Uvod/Cilj. Inflamacija je jedan od glavnih faktora odgovornih za nastanak vaskularnih komplikacija kod bolesnika sa terminalnom bubrežnom insuficijencijom. C reaktivni protein (CRP) se smatra senzitivnim markerom sistemske inflamacije, kao i faktorom koji doprinosi povećanom riziku od opšteg i kardiovaskularnog mortaliteta. Albumin je negativni protein akutne faze zapaljenja i njegova sinteza opada sa napredovanjem sistemske inflamacije. Za bolesnike na hemodijalizi poznato je da pate od visokog stepena proteinske malnutricije usled smanjene sinteze proteina i njihove pojačane razgradnje. Nizak nivo serumskog albumina kod tih bolesnika je posledica kompleksnog stanja koje podrazumeva sistemsku inflamaciju, malnutriciju i prekomernu hidrataciju. Cilj naše studije bio je da se ispita učestalost povišenog serumskog CRP-a u našoj populaciji dijaliznih bolesnika i da se utvrdi stepen njegove korelacije sa serumskim albuminom i drugim parametrima nutritivnog statusa. Metode. Ispitivanjem je obuhvaćeno 49 bolesnika na hroničnom programu hemodijalize u Centru za hemodijalizu Klinike za nefrologiju Vojnomedicinske akademije u Beogradu. Uzorci krvi za analizu uzimani su tokom punkcije arteriovenske fistule, a pre druge nedeljne hemodijalize. Određivanu su sledeći parametri: serumski nivo uree i kreatinina pre i posle procedure, CRP, hemoglobin, glikemija, ukupni holesterol, trigliceridi, glikozilirani hemoglobin (HbA1c), insulinemija i C-peptid pre hemodijalize. Rezultati. Od ukupno 49 dijaliznih bolesnika, bilo je 37 (75,5%) muškaraca i 12 (24,5%) žena, prosečne starosti 56,04 ± 13,93 godine. Dužina lečenja hemodijalizom je prosečno iznosila 7,37 ± 5 godina. Povišene vrednosti serumskog CRP-a (više od 3 mg/L) imalo je 65,3% bolesnika. U grupi bolesnika sa povišenim nivoom CRP-a u serumu, bilo je značajno više dijabetičara (n=12) u odnosu na grupu sa normalnim nivoom CRP-a u serumu (n = 3) (p ≤ 0,05). Uočili smo postojanje značajne pozitivne korelacije između serumskog CRP-a i serumske uree nakon dijaliznog procesa. U ispitivanoj grupi postojala je negativna korelacija između serumskog CRPa i serumskog albumina, HbA1c, ukupnog holesterola i triglicerida. Ta korelacija nije bila statistički značajna. Zaključak. Naša studija je potvrdila visok stepen sistemske inflamacije kod dijaliznih bolesnika izražene kroz visoku učestalost povišenih vrednosti serumskog CRP-a. Negativna korelacija između nivoa serumskog CRP-a i serumskog albumina kao i drugih nutritivnih parametara, sugeriše da hronična inflamacija može biti ključna karika koja povezuje proteinsku malnutriciju sa visokim morbiditetom i mortalitetom ovih bolesnika.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Serum C-reactive protein and nutritional parameters in hemodialysis patients
T1  - Serumski C-reaktivni protein i nutritivni parametri kod bolesnika na hemodijalizi
EP  - 727
IS  - 7
SP  - 723
VL  - 76
DO  - 10.2298/VSP160912155D
ER  - 

@article{
author = "Dragović, Tamara and Mijušković, Mirjana and Terzić, Brankica and Ristić-Medić, Danijela and Hajduković, Zoran and Rađen, Slavica",
year = "2019",
abstract = "Background/Aim. Inflammation is the most important factor in the genesis of vascular complication in the endstage renal disease. The serum C-reactive protein (CRP) level is a sensitive marker of systemic inflammation as well as a predisposing factor for cardiovascular and all cause mortality in patients on hemodialysis. Albumin is the negative acute phase protein and its synthesis declines during the inflammation. The patients undergoing hemodialysis have a high prevalence of protein-energy malnutrition, due to reduced protein synthesis and increased degradation. The low serum albumin levels in these patients originate from the complex setting of conditions with systemic inflammatory response as a major cause, malnutrition and overhydratation. The aim of this study was to determine the prevalence of elevated CRP levels in the dialysis patients and to analyse its correlation with serum albumin levels and other parameters of nutritional status. Methods. The study included 49 patients on maintenance hemodialysis at the Department of Hemodialysis, Clinic of Nephrology, Military Medical Academy, Belgrade, Serbia. In order to analyse the parameters, the blood samples were taken during the arteriovenous fistula (AVF) puncture and before the second weekly dialyse. The following parameters were determined: serum levels of urea and creatinine before and after the dialysis procedure, CRP, hemoglobin, fasting glycemia, total cholesterol, triglycerides, albumins, iron, glycosylated hemoglobin (HbA1c), fasting insulinemia and C-peptide only before the dialysis. Results. Out of 49 patients on maintenance hemodialysis, 37 (75.5%) were males and 12 (24.5%) females with the average age of 56.04 ± 13.93 years. The average duration of the dialysis treatment was 7.37 ± 5 years. The high serum CRP levels (more than 3 mg/L) was found in 65.3% of patients. Singificantly more diabetic patients were observed in the group with the higher CRP levels (n = 12) compared to the group with the normal CRP levels (n = 3) (p ≤ 0.05). A significant positive correlation was found between the CRP value and urea values after the dialysis procedure. We found negative correlation between the CRP values and serum albumin, HbA1c, total cholesterol and triglyceride levels, with no statistical significance. Conclusion. Our study observed a high rate of inflammation in the dialysis patients presenting as high frequency of the elevated CRP levels in the examined group. Negative correlation between CRP levels and serum albumin as well as with some other parameters of nutritional status, suggests that chronic inflammation may be the missing link that actually connect protein energy malnutrition with high morbiditiy and mortality rate in these patients., Uvod/Cilj. Inflamacija je jedan od glavnih faktora odgovornih za nastanak vaskularnih komplikacija kod bolesnika sa terminalnom bubrežnom insuficijencijom. C reaktivni protein (CRP) se smatra senzitivnim markerom sistemske inflamacije, kao i faktorom koji doprinosi povećanom riziku od opšteg i kardiovaskularnog mortaliteta. Albumin je negativni protein akutne faze zapaljenja i njegova sinteza opada sa napredovanjem sistemske inflamacije. Za bolesnike na hemodijalizi poznato je da pate od visokog stepena proteinske malnutricije usled smanjene sinteze proteina i njihove pojačane razgradnje. Nizak nivo serumskog albumina kod tih bolesnika je posledica kompleksnog stanja koje podrazumeva sistemsku inflamaciju, malnutriciju i prekomernu hidrataciju. Cilj naše studije bio je da se ispita učestalost povišenog serumskog CRP-a u našoj populaciji dijaliznih bolesnika i da se utvrdi stepen njegove korelacije sa serumskim albuminom i drugim parametrima nutritivnog statusa. Metode. Ispitivanjem je obuhvaćeno 49 bolesnika na hroničnom programu hemodijalize u Centru za hemodijalizu Klinike za nefrologiju Vojnomedicinske akademije u Beogradu. Uzorci krvi za analizu uzimani su tokom punkcije arteriovenske fistule, a pre druge nedeljne hemodijalize. Određivanu su sledeći parametri: serumski nivo uree i kreatinina pre i posle procedure, CRP, hemoglobin, glikemija, ukupni holesterol, trigliceridi, glikozilirani hemoglobin (HbA1c), insulinemija i C-peptid pre hemodijalize. Rezultati. Od ukupno 49 dijaliznih bolesnika, bilo je 37 (75,5%) muškaraca i 12 (24,5%) žena, prosečne starosti 56,04 ± 13,93 godine. Dužina lečenja hemodijalizom je prosečno iznosila 7,37 ± 5 godina. Povišene vrednosti serumskog CRP-a (više od 3 mg/L) imalo je 65,3% bolesnika. U grupi bolesnika sa povišenim nivoom CRP-a u serumu, bilo je značajno više dijabetičara (n=12) u odnosu na grupu sa normalnim nivoom CRP-a u serumu (n = 3) (p ≤ 0,05). Uočili smo postojanje značajne pozitivne korelacije između serumskog CRP-a i serumske uree nakon dijaliznog procesa. U ispitivanoj grupi postojala je negativna korelacija između serumskog CRPa i serumskog albumina, HbA1c, ukupnog holesterola i triglicerida. Ta korelacija nije bila statistički značajna. Zaključak. Naša studija je potvrdila visok stepen sistemske inflamacije kod dijaliznih bolesnika izražene kroz visoku učestalost povišenih vrednosti serumskog CRP-a. Negativna korelacija između nivoa serumskog CRP-a i serumskog albumina kao i drugih nutritivnih parametara, sugeriše da hronična inflamacija može biti ključna karika koja povezuje proteinsku malnutriciju sa visokim morbiditetom i mortalitetom ovih bolesnika.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Serum C-reactive protein and nutritional parameters in hemodialysis patients, Serumski C-reaktivni protein i nutritivni parametri kod bolesnika na hemodijalizi",
pages = "727-723",
number = "7",
volume = "76",
doi = "10.2298/VSP160912155D"
}

Dragović, T., Mijušković, M., Terzić, B., Ristić-Medić, D., Hajduković, Z.,& Rađen, S.. (2019). Serum C-reactive protein and nutritional parameters in hemodialysis patients. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 76(7), 723-727.
https://doi.org/10.2298/VSP160912155D

Dragović T, Mijušković M, Terzić B, Ristić-Medić D, Hajduković Z, Rađen S. Serum C-reactive protein and nutritional parameters in hemodialysis patients. in Vojnosanitetski pregled. 2019;76(7):723-727.
doi:10.2298/VSP160912155D .

Dragović, Tamara, Mijušković, Mirjana, Terzić, Brankica, Ristić-Medić, Danijela, Hajduković, Zoran, Rađen, Slavica, "Serum C-reactive protein and nutritional parameters in hemodialysis patients" in Vojnosanitetski pregled, 76, no. 7 (2019):723-727,
https://doi.org/10.2298/VSP160912155D . .

TY  - JOUR
AU  - Novaković, Romana
AU  - Geelen, Anouk
AU  - Ristić-Medić, Danijela
AU  - Nikolić, Marina
AU  - Souverein, Olga W.
AU  - McNulty, Helene
AU  - Duffy, Maresa
AU  - Hoey, Leane
AU  - Dullemeijer, Carla
AU  - Renkema, Jacoba M. S.
AU  - Gurinović, Mirjana
AU  - Glibetić, Marija
AU  - de Groot, Lisette
AU  - van't Veer, Pieter
PY  - 2018
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/844
AB  - Background: Dietary reference values for folate intake vary widely across Europe. Methods: MEDLINE and Embase through November 2016 were searched for data on the association between folate intake and biomarkers (serum/plasma folate, red blood cell [RBC] folate, plasma homocysteine) from observational studies in healthy adults and elderly. The regression coefficient of biomarkers on intake (beta) was extracted from each study, and the overall and stratified pooled beta and SE (beta) were obtained by random effects meta-analysis on a double log scale. These dose-response estimates may be used to derive folate intake reference values. Results: For every doubling in folate intake, the changes in serum/plasma folate, RBC folate and plasma homocysteine were +22, +21, and -16% respectively. The overall pooled regression coefficients were beta = 0.29 (95% CI 0.21-0.37) for serum/plasma folate (26 estimates from 17 studies), beta = 0.28 (95% CI 0.21-0.36) for RBC (13 estimates from 11 studies), and beta = -0.21 (95% CI -0.31 to -0.11) for plasma homocysteine (10 estimates from 6 studies). Conclusion: These estimates along with those from randomized controlled trials can be used for underpinning dietary recommendations for folate in adults and elderly.
PB  - Karger, Basel
T2  - Annals of Nutrition & Metabolism
T1  - Systematic Review of Observational Studies with Dose-Response Meta-Analysis between Folate Intake and Status Biomarkers in Adults and the Elderly
EP  - 43
IS  - 1
SP  - 30
VL  - 73
DO  - 10.1159/000490003
ER  - 

@article{
author = "Novaković, Romana and Geelen, Anouk and Ristić-Medić, Danijela and Nikolić, Marina and Souverein, Olga W. and McNulty, Helene and Duffy, Maresa and Hoey, Leane and Dullemeijer, Carla and Renkema, Jacoba M. S. and Gurinović, Mirjana and Glibetić, Marija and de Groot, Lisette and van't Veer, Pieter",
year = "2018",
abstract = "Background: Dietary reference values for folate intake vary widely across Europe. Methods: MEDLINE and Embase through November 2016 were searched for data on the association between folate intake and biomarkers (serum/plasma folate, red blood cell [RBC] folate, plasma homocysteine) from observational studies in healthy adults and elderly. The regression coefficient of biomarkers on intake (beta) was extracted from each study, and the overall and stratified pooled beta and SE (beta) were obtained by random effects meta-analysis on a double log scale. These dose-response estimates may be used to derive folate intake reference values. Results: For every doubling in folate intake, the changes in serum/plasma folate, RBC folate and plasma homocysteine were +22, +21, and -16% respectively. The overall pooled regression coefficients were beta = 0.29 (95% CI 0.21-0.37) for serum/plasma folate (26 estimates from 17 studies), beta = 0.28 (95% CI 0.21-0.36) for RBC (13 estimates from 11 studies), and beta = -0.21 (95% CI -0.31 to -0.11) for plasma homocysteine (10 estimates from 6 studies). Conclusion: These estimates along with those from randomized controlled trials can be used for underpinning dietary recommendations for folate in adults and elderly.",
publisher = "Karger, Basel",
journal = "Annals of Nutrition & Metabolism",
title = "Systematic Review of Observational Studies with Dose-Response Meta-Analysis between Folate Intake and Status Biomarkers in Adults and the Elderly",
pages = "43-30",
number = "1",
volume = "73",
doi = "10.1159/000490003"
}

Novaković, R., Geelen, A., Ristić-Medić, D., Nikolić, M., Souverein, O. W., McNulty, H., Duffy, M., Hoey, L., Dullemeijer, C., Renkema, J. M. S., Gurinović, M., Glibetić, M., de Groot, L.,& van't Veer, P.. (2018). Systematic Review of Observational Studies with Dose-Response Meta-Analysis between Folate Intake and Status Biomarkers in Adults and the Elderly. in Annals of Nutrition & Metabolism
Karger, Basel., 73(1), 30-43.
https://doi.org/10.1159/000490003

Novaković R, Geelen A, Ristić-Medić D, Nikolić M, Souverein OW, McNulty H, Duffy M, Hoey L, Dullemeijer C, Renkema JMS, Gurinović M, Glibetić M, de Groot L, van't Veer P. Systematic Review of Observational Studies with Dose-Response Meta-Analysis between Folate Intake and Status Biomarkers in Adults and the Elderly. in Annals of Nutrition & Metabolism. 2018;73(1):30-43.
doi:10.1159/000490003 .

Novaković, Romana, Geelen, Anouk, Ristić-Medić, Danijela, Nikolić, Marina, Souverein, Olga W., McNulty, Helene, Duffy, Maresa, Hoey, Leane, Dullemeijer, Carla, Renkema, Jacoba M. S., Gurinović, Mirjana, Glibetić, Marija, de Groot, Lisette, van't Veer, Pieter, "Systematic Review of Observational Studies with Dose-Response Meta-Analysis between Folate Intake and Status Biomarkers in Adults and the Elderly" in Annals of Nutrition & Metabolism, 73, no. 1 (2018):30-43,
https://doi.org/10.1159/000490003 . .

TY  - JOUR
AU  - Stojanović, Ana
AU  - Zeković, Milica
AU  - Rašić-Milutinović, Zorica
AU  - Ristić-Medić, Danijela
AU  - Pokimica, Biljana
AU  - Debeljak-Martačić, Jasmina
AU  - Vučić, Vesna M.
PY  - 2018
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/899
AB  - Introduction/Objective Although smoking is the main risk factor for lung cancer (LC), studies have shown that diet could also play an important role. The objective of this study was to analyze dietary intake of newly diagnosed LC patients and to compare with sex- and age-matched healthy controls. Methods Sixty-nine non-treated LC patients (50 male, 19 female, aged 46-80 years), and 70 healthy controls (50 male, 20 female, aged 47-76 years) filled out a validated food frequency questionnaire in the presence of a trained nutritionist. Nutrient intake was calculated using the Serbian Food Composition Database. Results Similar energy intake was reported by both groups. However, the controls had significantly higher intake of total fats, saturated, monounsaturated, and n-3 polyunsaturated fatty acids (PUFAs) and lower intake of carbohydrates and n-6 PUFAs. Patients with LC reported markedly lower intake of milk and dairy products, eggs, seafood, vegetables, and fruits, and higher intake of grains and grain products. Conclusion Patients with LC had significantly different dietary intake of most nutrients compared to healthy participants, suggesting that changes in dietary patterns could contribute to prevention of LC development.
AB  - Uvod/Cilj Iako je pušenje vodeći faktor rizika za rak pluća (RP), studije pokazuju da i način ishrane igra važnu ulogu. Cilj ove studije je da se analiza ishrana kod bolesnika sa novodijagnostikovanim RP i da se uporedi sa zdravom populacijom istog pola i godina starosti. Metode Šezdeset devet bolesnika sa novootkrivenim RP (50 muškaraca, 19 žena, starosti 46-80 godina) i 70 zdravih ispitanika (50 muškaraca, 20 žena, starosti 47-76 godina) popunilo je u prisustvu lekara upitnik o učestalosti kon- zumiranja namirnica. Nutritivni unos je računat pomoću Srpske baze podataka o sastavu namirnica. Rezultati Obe grupe su imale sličan unos energije, ali je u kontrolnoj grupi zabeležen veći unos masti, zasićenih, mononezasićenih i n-3 polinezasićenih masnih kiselina (PNMK), a niži unos ugljenih hidrata i n-6 PNMK. Grupa bolesnika je imala značajno niži unos mleka i mlečnih proizvoda, jaja, morskih plodova, voća i povrća, a veći unos žitarica i proizvoda od brašna. Zaključak Bolesnici sa RP imali su značajno drugačiji način ishrane od zdravih ispitanika, što sugeriše da promene u načinu ishrane mogu da doprinesu prevenciji nastanka kancera pluća.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Dietary intake in newly diagnosed lung cancer patients
T1  - Ishrana bolesnika sa novodijagnostikovanim rakom pluća
EP  - 30
IS  - 1-2
SP  - 26
VL  - 146
DO  - 10.2298/SARH170301115S
ER  - 

@article{
author = "Stojanović, Ana and Zeković, Milica and Rašić-Milutinović, Zorica and Ristić-Medić, Danijela and Pokimica, Biljana and Debeljak-Martačić, Jasmina and Vučić, Vesna M.",
year = "2018",
abstract = "Introduction/Objective Although smoking is the main risk factor for lung cancer (LC), studies have shown that diet could also play an important role. The objective of this study was to analyze dietary intake of newly diagnosed LC patients and to compare with sex- and age-matched healthy controls. Methods Sixty-nine non-treated LC patients (50 male, 19 female, aged 46-80 years), and 70 healthy controls (50 male, 20 female, aged 47-76 years) filled out a validated food frequency questionnaire in the presence of a trained nutritionist. Nutrient intake was calculated using the Serbian Food Composition Database. Results Similar energy intake was reported by both groups. However, the controls had significantly higher intake of total fats, saturated, monounsaturated, and n-3 polyunsaturated fatty acids (PUFAs) and lower intake of carbohydrates and n-6 PUFAs. Patients with LC reported markedly lower intake of milk and dairy products, eggs, seafood, vegetables, and fruits, and higher intake of grains and grain products. Conclusion Patients with LC had significantly different dietary intake of most nutrients compared to healthy participants, suggesting that changes in dietary patterns could contribute to prevention of LC development., Uvod/Cilj Iako je pušenje vodeći faktor rizika za rak pluća (RP), studije pokazuju da i način ishrane igra važnu ulogu. Cilj ove studije je da se analiza ishrana kod bolesnika sa novodijagnostikovanim RP i da se uporedi sa zdravom populacijom istog pola i godina starosti. Metode Šezdeset devet bolesnika sa novootkrivenim RP (50 muškaraca, 19 žena, starosti 46-80 godina) i 70 zdravih ispitanika (50 muškaraca, 20 žena, starosti 47-76 godina) popunilo je u prisustvu lekara upitnik o učestalosti kon- zumiranja namirnica. Nutritivni unos je računat pomoću Srpske baze podataka o sastavu namirnica. Rezultati Obe grupe su imale sličan unos energije, ali je u kontrolnoj grupi zabeležen veći unos masti, zasićenih, mononezasićenih i n-3 polinezasićenih masnih kiselina (PNMK), a niži unos ugljenih hidrata i n-6 PNMK. Grupa bolesnika je imala značajno niži unos mleka i mlečnih proizvoda, jaja, morskih plodova, voća i povrća, a veći unos žitarica i proizvoda od brašna. Zaključak Bolesnici sa RP imali su značajno drugačiji način ishrane od zdravih ispitanika, što sugeriše da promene u načinu ishrane mogu da doprinesu prevenciji nastanka kancera pluća.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Dietary intake in newly diagnosed lung cancer patients, Ishrana bolesnika sa novodijagnostikovanim rakom pluća",
pages = "30-26",
number = "1-2",
volume = "146",
doi = "10.2298/SARH170301115S"
}

Stojanović, A., Zeković, M., Rašić-Milutinović, Z., Ristić-Medić, D., Pokimica, B., Debeljak-Martačić, J.,& Vučić, V. M.. (2018). Dietary intake in newly diagnosed lung cancer patients. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 146(1-2), 26-30.
https://doi.org/10.2298/SARH170301115S

Stojanović A, Zeković M, Rašić-Milutinović Z, Ristić-Medić D, Pokimica B, Debeljak-Martačić J, Vučić VM. Dietary intake in newly diagnosed lung cancer patients. in Srpski arhiv za celokupno lekarstvo. 2018;146(1-2):26-30.
doi:10.2298/SARH170301115S .

Stojanović, Ana, Zeković, Milica, Rašić-Milutinović, Zorica, Ristić-Medić, Danijela, Pokimica, Biljana, Debeljak-Martačić, Jasmina, Vučić, Vesna M., "Dietary intake in newly diagnosed lung cancer patients" in Srpski arhiv za celokupno lekarstvo, 146, no. 1-2 (2018):26-30,
https://doi.org/10.2298/SARH170301115S . .

TY  - JOUR
AU  - Rađen, Slavica
AU  - Ristić-Medić, Danijela
AU  - Terzić, Brankica
AU  - Đurović, Branka
AU  - Mijušković, Mirjana
PY  - 2018
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/886
AB  - The available evidence suggests that nutritional status in the HD patients is an extremely important predictive and causative factor for the good clinical outcome. Nutritional deficits and PEW are frequent problems in the dialysis population and implies an increased risk of negative health outcomes such as mortality risk and quality of life deterioration. There is no single specific measurement that provides complete assessment of the nutritional status in the HD patients, and the results should be analysed in the clinical context of each individual patients. As malnutrition is potentially reversible with appropriate nutritional support, early identification of patients at high nutritional risk may facilitate effective treatment and improve prognosis in the HD patients. .
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Protein-energy wasting in maintenance hemodialysis patients: Etiology and diagnosis
T1  - Proteinsko-energetski gubitak kod bolesnika na hroničnoj hemodijalizi - etiologija i dijagnostički kriterijumi
EP  - 409
IS  - 4
SP  - 404
VL  - 75
DO  - 10.2298/VSP160902352R
ER  - 

@article{
author = "Rađen, Slavica and Ristić-Medić, Danijela and Terzić, Brankica and Đurović, Branka and Mijušković, Mirjana",
year = "2018",
abstract = "The available evidence suggests that nutritional status in the HD patients is an extremely important predictive and causative factor for the good clinical outcome. Nutritional deficits and PEW are frequent problems in the dialysis population and implies an increased risk of negative health outcomes such as mortality risk and quality of life deterioration. There is no single specific measurement that provides complete assessment of the nutritional status in the HD patients, and the results should be analysed in the clinical context of each individual patients. As malnutrition is potentially reversible with appropriate nutritional support, early identification of patients at high nutritional risk may facilitate effective treatment and improve prognosis in the HD patients. .",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Protein-energy wasting in maintenance hemodialysis patients: Etiology and diagnosis, Proteinsko-energetski gubitak kod bolesnika na hroničnoj hemodijalizi - etiologija i dijagnostički kriterijumi",
pages = "409-404",
number = "4",
volume = "75",
doi = "10.2298/VSP160902352R"
}

Rađen, S., Ristić-Medić, D., Terzić, B., Đurović, B.,& Mijušković, M.. (2018). Protein-energy wasting in maintenance hemodialysis patients: Etiology and diagnosis. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 75(4), 404-409.
https://doi.org/10.2298/VSP160902352R

Rađen S, Ristić-Medić D, Terzić B, Đurović B, Mijušković M. Protein-energy wasting in maintenance hemodialysis patients: Etiology and diagnosis. in Vojnosanitetski pregled. 2018;75(4):404-409.
doi:10.2298/VSP160902352R .

Rađen, Slavica, Ristić-Medić, Danijela, Terzić, Brankica, Đurović, Branka, Mijušković, Mirjana, "Protein-energy wasting in maintenance hemodialysis patients: Etiology and diagnosis" in Vojnosanitetski pregled, 75, no. 4 (2018):404-409,
https://doi.org/10.2298/VSP160902352R . .

TY  - JOUR
AU  - Timić, Jasmina B.
AU  - Duricić, Ivana D.
AU  - Ristić-Medić, Danijela
AU  - Sobajić, Slađana S.
PY  - 2018
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/888
AB  - The rapid increase in the consumption of salty snack products has led to increased concern about their composition and nutritional value. The aim of this study was to investigate the fat content and fatty acid profile in salty snack products from the Serbian market. A total of 58 different snack products from 3 categories (Baked products, Chips & flips products, Cereal products) were analyzed. The fatty acid composition was determined using gas chromatography. Total fat content ranged from 3.1 % in expanded rice to 35.7 % in potato chips. Palmitic, oleic and linoleic acids constituted  gt  80 % of all fatty acids (FAs) in categories Baked products and Chips & flips. Linoleic acid was more abundant in the category Cereal products (15.5-49.3 %). The trans-FAs elaidic (C18:1 - 9t) and linolelaidic FAs (18: 2 - 9t, 12t) were identified in 66 % of the products. The flips products had the highest average t-FAs content (16.3 %), followed by flips group (9.3 %). Potential t-FAs intake from 100 g of analyzed products was in range 0.1-4.9 g. This study provided a large database on saturated fatty acids and t-FAs content in salty snack products and indicated that by consuming only one package of some products, the t-FAs intake could surpass the recommended maximum of 1 % of daily energy.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Fatty acid composition including trans-fatty acids in salty snack food from the Serbian market
EP  - 698
IS  - 6
SP  - 685
VL  - 83
DO  - 10.2298/JSC180207039T
ER  - 

@article{
author = "Timić, Jasmina B. and Duricić, Ivana D. and Ristić-Medić, Danijela and Sobajić, Slađana S.",
year = "2018",
abstract = "The rapid increase in the consumption of salty snack products has led to increased concern about their composition and nutritional value. The aim of this study was to investigate the fat content and fatty acid profile in salty snack products from the Serbian market. A total of 58 different snack products from 3 categories (Baked products, Chips & flips products, Cereal products) were analyzed. The fatty acid composition was determined using gas chromatography. Total fat content ranged from 3.1 % in expanded rice to 35.7 % in potato chips. Palmitic, oleic and linoleic acids constituted  gt  80 % of all fatty acids (FAs) in categories Baked products and Chips & flips. Linoleic acid was more abundant in the category Cereal products (15.5-49.3 %). The trans-FAs elaidic (C18:1 - 9t) and linolelaidic FAs (18: 2 - 9t, 12t) were identified in 66 % of the products. The flips products had the highest average t-FAs content (16.3 %), followed by flips group (9.3 %). Potential t-FAs intake from 100 g of analyzed products was in range 0.1-4.9 g. This study provided a large database on saturated fatty acids and t-FAs content in salty snack products and indicated that by consuming only one package of some products, the t-FAs intake could surpass the recommended maximum of 1 % of daily energy.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Fatty acid composition including trans-fatty acids in salty snack food from the Serbian market",
pages = "698-685",
number = "6",
volume = "83",
doi = "10.2298/JSC180207039T"
}

Timić, J. B., Duricić, I. D., Ristić-Medić, D.,& Sobajić, S. S.. (2018). Fatty acid composition including trans-fatty acids in salty snack food from the Serbian market. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 83(6), 685-698.
https://doi.org/10.2298/JSC180207039T

Timić JB, Duricić ID, Ristić-Medić D, Sobajić SS. Fatty acid composition including trans-fatty acids in salty snack food from the Serbian market. in Journal of the Serbian Chemical Society. 2018;83(6):685-698.
doi:10.2298/JSC180207039T .

Timić, Jasmina B., Duricić, Ivana D., Ristić-Medić, Danijela, Sobajić, Slađana S., "Fatty acid composition including trans-fatty acids in salty snack food from the Serbian market" in Journal of the Serbian Chemical Society, 83, no. 6 (2018):685-698,
https://doi.org/10.2298/JSC180207039T . .