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Specificity of 3D MSC Spheroids Microenvironment: Impact on MSC Behavior and Properties
(Springer, New York, 2020)
Mesenchymal stem cells (MSC) have been considered the promising candidates for the regenerative and personalized medicine due to their self-renewal potential, multilineage differentiation and immunomodulatory capacity. ...
Adipogenesis in Different Body Depots and Tumor Development
(Frontiers Media Sa, Lausanne, 2020)
Adipose tissue (AT) forms depots at different anatomical locations throughout the body, being in subcutaneous and visceral regions, as well as the bone marrow. These ATs differ in the adipocyte functional profile, their ...
Extracellular Vesicles in Musculoskeletal Pathologies and Regeneration
(Frontiers in Bioengineering & Biotechnology, 2021)
The incidence of musculoskeletal diseases is steadily increasing with aging of the population. In the past years, extracellular vesicles (EVs) have gained attention in musculoskeletal research. EVs have been associated ...
Analysis of cell-biomaterial interaction through cellular bridge formation in the interface between hGMSCs and CaP bioceramics
(Nature Research, Berlin, 2020)
The combination of biomaterials and stem cells for clinical applications constitute a great challenge in bone tissue engineering. Hence, cellular networks derived from cells-biomaterials crosstalk have a profound influence ...
Targeting Histone Deacetylases: Opportunities for Cancer Treatment and Chemoprevention
(Pharmaceutics, 2022)
The dysregulation of gene expression is a critical event involved in all steps of tumorigenesis. Aberrant histone and non-histone acetylation modifications of gene expression due to the abnormal activation of histone ...
Dynamics of impulsive-compulsive behaviors in early Parkinson's disease: a prospective study
(Springer Heidelberg, Heidelberg, 2020)
Introduction Impulsive compulsive behaviors (ICBs) in Parkinson's disease (PD) are debilitating disorders of repetitive, excessive, and compulsive nature affecting up to one third of PD patients. Objectives are to address ...
Endothelial dysfunction in pregnancy metabolic disorders
(Elsevier, Amsterdam, 2020)
In recent years, the vascular endothelium has gained attention as a key player in the initiation and development of pregnancy disorders. Endothelium acts as an endocrine organ that preserves the homeostatic balance by ...
Mitochondrial Function and Dysfunction in Dilated Cardiomyopathy
(Frontiers Media Sa, Lausanne, 2021)
Cardiac tissue requires a persistent production of energy in order to exert its pumping function. Therefore, the maintenance of this function relies on mitochondria that represent the "powerhouse" of all cardiac activities. ...
Structural characteristics of circulating immune complexes in calves with bronchopneumonia: Impact on the quiescent leukocytes
(Elsevier Sci Ltd, Oxford, 2020)
Calf bronchopneumonia is accompanied by increased level of circulating immune complexes (CIC), and we analysed size, and protein and lipid constituents of these CIC with an attempt to elucidate the connection between the ...
Native bovine hemoglobin reduces differentiation capacity of mesenchymal stromal cells in vitro
(Elsevier, Amsterdam, 2020)
We have tested in vitro effects of hemoglobin from bovine slaughterhouse blood (BHb) on stromal cells of mesodermal origin, with an aim to explore its use as a component of cell culture media. Human peripheral blood ...