Mitochondrial Function and Dysfunction in Dilated Cardiomyopathy
2021
Аутори
Ramaccini, DanielaMontoya-Uribe, Vanessa
Aan, Femke J.
Modesti, Lorenzo
Potes, Yaiza
Wieckowski, Mariusz R.
Krga, Irena
Glibetić, Marija
Pinton, Paolo
Giorgi, Carlotta
Matter, Michelle L.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Cardiac tissue requires a persistent production of energy in order to exert its pumping function. Therefore, the maintenance of this function relies on mitochondria that represent the "powerhouse" of all cardiac activities. Mitochondria being one of the key players for the proper functioning of the mammalian heart suggests continual regulation and organization. Mitochondria adapt to cellular energy demands via fusion-fission events and, as a proof-reading ability, undergo mitophagy in cases of abnormalities. Ca2+ fluxes play a pivotal role in regulating all mitochondrial functions, including ATP production, metabolism, oxidative stress balance and apoptosis. Communication between mitochondria and others organelles, especially the sarcoplasmic reticulum is required for optimal function. Consequently, abnormal mitochondrial activity results in decreased energy production leading to pathological conditions. In this review, we will describe how mitochondrial function or dysfunction impacts... cardiac activities and the development of dilated cardiomyopathy.
Кључне речи:
mitochondria / cardiomyocytes / cardiomyopathies / organoids model / sarcoplasmic reticulum / Ca ATPase (SERCA) 2+ / calcium / heart functionИзвор:
Frontiers in Cell and Developmental Biology, 2021, 8, 624216-Издавач:
- Frontiers Media Sa, Lausanne
Финансирање / пројекти:
- United States Department of Health & Human Services National Institutes of Health (NIH) - USA [R01HD091162]
- Italian Association for Cancer Research Associazione Italiana per la Ricerca sul Cancro (AIRC) [IG-19803, IG-23670]
- Progettidi Rilevante Interesse Nazionale Ministry of Education, Universities and Research (MIUR) Research Projects of National Relevance (PRIN) [PRIN20177E9EPY, PRIN2017E5L5P3]
- University of FerDrara
- A-ROSE
- Poland National Science Centre [UMO02018/29/B/NZ1/00589]
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200015 (Универзитет у Београду, Институт за медицинска истраживања) (RS-MESTD-inst-2020-200015)
DOI: 10.3389/fcell.2020.624216
ISSN: 2296-634X
PubMed: 33511136
WoS: 000611511400001
Scopus: 2-s2.0-85100064404
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Ramaccini, Daniela AU - Montoya-Uribe, Vanessa AU - Aan, Femke J. AU - Modesti, Lorenzo AU - Potes, Yaiza AU - Wieckowski, Mariusz R. AU - Krga, Irena AU - Glibetić, Marija AU - Pinton, Paolo AU - Giorgi, Carlotta AU - Matter, Michelle L. PY - 2021 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1079 AB - Cardiac tissue requires a persistent production of energy in order to exert its pumping function. Therefore, the maintenance of this function relies on mitochondria that represent the "powerhouse" of all cardiac activities. Mitochondria being one of the key players for the proper functioning of the mammalian heart suggests continual regulation and organization. Mitochondria adapt to cellular energy demands via fusion-fission events and, as a proof-reading ability, undergo mitophagy in cases of abnormalities. Ca2+ fluxes play a pivotal role in regulating all mitochondrial functions, including ATP production, metabolism, oxidative stress balance and apoptosis. Communication between mitochondria and others organelles, especially the sarcoplasmic reticulum is required for optimal function. Consequently, abnormal mitochondrial activity results in decreased energy production leading to pathological conditions. In this review, we will describe how mitochondrial function or dysfunction impacts cardiac activities and the development of dilated cardiomyopathy. PB - Frontiers Media Sa, Lausanne T2 - Frontiers in Cell and Developmental Biology T1 - Mitochondrial Function and Dysfunction in Dilated Cardiomyopathy SP - 624216 VL - 8 DO - 10.3389/fcell.2020.624216 ER -
@article{ author = "Ramaccini, Daniela and Montoya-Uribe, Vanessa and Aan, Femke J. and Modesti, Lorenzo and Potes, Yaiza and Wieckowski, Mariusz R. and Krga, Irena and Glibetić, Marija and Pinton, Paolo and Giorgi, Carlotta and Matter, Michelle L.", year = "2021", abstract = "Cardiac tissue requires a persistent production of energy in order to exert its pumping function. Therefore, the maintenance of this function relies on mitochondria that represent the "powerhouse" of all cardiac activities. Mitochondria being one of the key players for the proper functioning of the mammalian heart suggests continual regulation and organization. Mitochondria adapt to cellular energy demands via fusion-fission events and, as a proof-reading ability, undergo mitophagy in cases of abnormalities. Ca2+ fluxes play a pivotal role in regulating all mitochondrial functions, including ATP production, metabolism, oxidative stress balance and apoptosis. Communication between mitochondria and others organelles, especially the sarcoplasmic reticulum is required for optimal function. Consequently, abnormal mitochondrial activity results in decreased energy production leading to pathological conditions. In this review, we will describe how mitochondrial function or dysfunction impacts cardiac activities and the development of dilated cardiomyopathy.", publisher = "Frontiers Media Sa, Lausanne", journal = "Frontiers in Cell and Developmental Biology", title = "Mitochondrial Function and Dysfunction in Dilated Cardiomyopathy", pages = "624216", volume = "8", doi = "10.3389/fcell.2020.624216" }
Ramaccini, D., Montoya-Uribe, V., Aan, F. J., Modesti, L., Potes, Y., Wieckowski, M. R., Krga, I., Glibetić, M., Pinton, P., Giorgi, C.,& Matter, M. L.. (2021). Mitochondrial Function and Dysfunction in Dilated Cardiomyopathy. in Frontiers in Cell and Developmental Biology Frontiers Media Sa, Lausanne., 8, 624216. https://doi.org/10.3389/fcell.2020.624216
Ramaccini D, Montoya-Uribe V, Aan FJ, Modesti L, Potes Y, Wieckowski MR, Krga I, Glibetić M, Pinton P, Giorgi C, Matter ML. Mitochondrial Function and Dysfunction in Dilated Cardiomyopathy. in Frontiers in Cell and Developmental Biology. 2021;8:624216. doi:10.3389/fcell.2020.624216 .
Ramaccini, Daniela, Montoya-Uribe, Vanessa, Aan, Femke J., Modesti, Lorenzo, Potes, Yaiza, Wieckowski, Mariusz R., Krga, Irena, Glibetić, Marija, Pinton, Paolo, Giorgi, Carlotta, Matter, Michelle L., "Mitochondrial Function and Dysfunction in Dilated Cardiomyopathy" in Frontiers in Cell and Developmental Biology, 8 (2021):624216, https://doi.org/10.3389/fcell.2020.624216 . .