TY  - JOUR
AU  - Đukić, Tamara
AU  - Drvenica, Ivana
AU  - Kovačić, Marijana
AU  - Milanović, Slađan
AU  - Majerič, Dragana
AU  - Šefik-Bukilica, Mirjana
AU  - Miletić, Maja
AU  - Bugarski, Branko
AU  - Ilić, Vesna
PY  - 2024
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1474
AB  - The function of immune complexes in rheumatoid arthritis (RA) is related to their composition and size. Using dynamic light scattering (DLS), we investigated the link between the RA circulating immune complex (CIC) particles’ size and the CIC immunoglobulin level. In this study, 30 RA patients and 30 healthy individuals were included. IgA, IgG, and IgM were found in all analyzed CICs, but more IgA and IgG were found in RA than in control CICs. In both control and RA CICs, DLS detected 50 particles that differed in size and clustered around two size groups: with a 7.5–164 nm radius and with a 342–1718 nm radius. An increased level of IgA in RA CICs, compared to control ones, was associated with more than 50% of CIC particles. In RA, compared to the control, a higher number of CICs with 28.2 nm, 531 nm, 712 nm, and 1718 nm particles and a lower number of CICs with 78.8 nm particles were detected. This particle distribution pattern did not reflect the changes in the CIC immunoglobulin level. Thus, RA elevated CIC IgA was linked with all these particles (except the 1718 nm particle), the IgM increase was linked with 43.8 nm and 712 nm particles, and the IgG increase was linked with the 712 nm particle only. This study provides the very first data on the association between CIC particles’ size, CIC immunoglobulin level, and RA. It opens the possibility that the size of CICs determined by DLS can be used as a criterion in RA diagnosis or monitoring after a large-scale study confirmation.
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
T2  - International Journal of Molecular Sciences
T1  - Exploring the Link between Hydrodynamic Size and Immunoglobulins of Circulating Immune Complexes in Rheumatoid Arthritis Patients
IS  - 6
SP  - 3138
VL  - 25
DO  - 10.3390/ijms25063138
ER  - 

@article{
author = "Đukić, Tamara and Drvenica, Ivana and Kovačić, Marijana and Milanović, Slađan and Majerič, Dragana and Šefik-Bukilica, Mirjana and Miletić, Maja and Bugarski, Branko and Ilić, Vesna",
year = "2024",
abstract = "The function of immune complexes in rheumatoid arthritis (RA) is related to their composition and size. Using dynamic light scattering (DLS), we investigated the link between the RA circulating immune complex (CIC) particles’ size and the CIC immunoglobulin level. In this study, 30 RA patients and 30 healthy individuals were included. IgA, IgG, and IgM were found in all analyzed CICs, but more IgA and IgG were found in RA than in control CICs. In both control and RA CICs, DLS detected 50 particles that differed in size and clustered around two size groups: with a 7.5–164 nm radius and with a 342–1718 nm radius. An increased level of IgA in RA CICs, compared to control ones, was associated with more than 50% of CIC particles. In RA, compared to the control, a higher number of CICs with 28.2 nm, 531 nm, 712 nm, and 1718 nm particles and a lower number of CICs with 78.8 nm particles were detected. This particle distribution pattern did not reflect the changes in the CIC immunoglobulin level. Thus, RA elevated CIC IgA was linked with all these particles (except the 1718 nm particle), the IgM increase was linked with 43.8 nm and 712 nm particles, and the IgG increase was linked with the 712 nm particle only. This study provides the very first data on the association between CIC particles’ size, CIC immunoglobulin level, and RA. It opens the possibility that the size of CICs determined by DLS can be used as a criterion in RA diagnosis or monitoring after a large-scale study confirmation.",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "International Journal of Molecular Sciences",
title = "Exploring the Link between Hydrodynamic Size and Immunoglobulins of Circulating Immune Complexes in Rheumatoid Arthritis Patients",
number = "6",
pages = "3138",
volume = "25",
doi = "10.3390/ijms25063138"
}

Đukić, T., Drvenica, I., Kovačić, M., Milanović, S., Majerič, D., Šefik-Bukilica, M., Miletić, M., Bugarski, B.,& Ilić, V.. (2024). Exploring the Link between Hydrodynamic Size and Immunoglobulins of Circulating Immune Complexes in Rheumatoid Arthritis Patients. in International Journal of Molecular Sciences
Multidisciplinary Digital Publishing Institute (MDPI)., 25(6), 3138.
https://doi.org/10.3390/ijms25063138

Đukić T, Drvenica I, Kovačić M, Milanović S, Majerič D, Šefik-Bukilica M, Miletić M, Bugarski B, Ilić V. Exploring the Link between Hydrodynamic Size and Immunoglobulins of Circulating Immune Complexes in Rheumatoid Arthritis Patients. in International Journal of Molecular Sciences. 2024;25(6):3138.
doi:10.3390/ijms25063138 .

Đukić, Tamara, Drvenica, Ivana, Kovačić, Marijana, Milanović, Slađan, Majerič, Dragana, Šefik-Bukilica, Mirjana, Miletić, Maja, Bugarski, Branko, Ilić, Vesna, "Exploring the Link between Hydrodynamic Size and Immunoglobulins of Circulating Immune Complexes in Rheumatoid Arthritis Patients" in International Journal of Molecular Sciences, 25, no. 6 (2024):3138,
https://doi.org/10.3390/ijms25063138 . .

TY  - JOUR
AU  - Milanović, Slobodan
AU  - Kaczmarowski, Jan
AU  - Ciesielski, Mariusz
AU  - Trailović, Zoran
AU  - Mielcarek, Miłosz
AU  - Szczygieł, Ryszard
AU  - Kwiatkowski, Mirosław
AU  - Bałazy, Radomir
AU  - Zasada, Michał
AU  - Milanović, Slađan
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1287
AB  - In recent years, forest fires have become an important issue in Central Europe. To model the probability of the occurrence of forest fires in the Lower Silesian Voivodeship of Poland, historical fire data and several types of predictors were collected or generated, including topographic, vegetation, climatic, and anthropogenic features. The main objectives of this study were to determine the importance of the predictors of forest fire occurrence and to map the probability of forest fire occurrence. The H2O driverless artificial intelligence (DAI) cloud platform was used to model forest fire probability. The gradient boosted machine (GBM) and random forest (RF) methods were applied to assess the probability of forest fire occurrence. Evaluation the importance of the variables was performed using the H2O platform permutation method. The most important variables were the presence of coniferous forest and the distance to agricultural land according to the GBM and RF methods, respectively. Model validation was conducted using receiver operating characteristic (ROC) analysis. The areas under the curve (AUCs) of the ROC plots from the GBM and RF models were 83.3% and 81.3%, respectively. Based on the results obtained, the GBM model can be recommended for the mapping of forest fire occurrence in the study area.
PB  - MDPI
T2  - Forests
T1  - Modeling and Mapping of Forest Fire Occurrence in the Lower Silesian Voivodeship of Poland Based on Machine Learning Methods
IS  - 1
SP  - 46
VL  - 14
DO  - 10.3390/f14010046
ER  - 

@article{
author = "Milanović, Slobodan and Kaczmarowski, Jan and Ciesielski, Mariusz and Trailović, Zoran and Mielcarek, Miłosz and Szczygieł, Ryszard and Kwiatkowski, Mirosław and Bałazy, Radomir and Zasada, Michał and Milanović, Slađan",
year = "2023",
abstract = "In recent years, forest fires have become an important issue in Central Europe. To model the probability of the occurrence of forest fires in the Lower Silesian Voivodeship of Poland, historical fire data and several types of predictors were collected or generated, including topographic, vegetation, climatic, and anthropogenic features. The main objectives of this study were to determine the importance of the predictors of forest fire occurrence and to map the probability of forest fire occurrence. The H2O driverless artificial intelligence (DAI) cloud platform was used to model forest fire probability. The gradient boosted machine (GBM) and random forest (RF) methods were applied to assess the probability of forest fire occurrence. Evaluation the importance of the variables was performed using the H2O platform permutation method. The most important variables were the presence of coniferous forest and the distance to agricultural land according to the GBM and RF methods, respectively. Model validation was conducted using receiver operating characteristic (ROC) analysis. The areas under the curve (AUCs) of the ROC plots from the GBM and RF models were 83.3% and 81.3%, respectively. Based on the results obtained, the GBM model can be recommended for the mapping of forest fire occurrence in the study area.",
publisher = "MDPI",
journal = "Forests",
title = "Modeling and Mapping of Forest Fire Occurrence in the Lower Silesian Voivodeship of Poland Based on Machine Learning Methods",
number = "1",
pages = "46",
volume = "14",
doi = "10.3390/f14010046"
}

Milanović, S., Kaczmarowski, J., Ciesielski, M., Trailović, Z., Mielcarek, M., Szczygieł, R., Kwiatkowski, M., Bałazy, R., Zasada, M.,& Milanović, S.. (2023). Modeling and Mapping of Forest Fire Occurrence in the Lower Silesian Voivodeship of Poland Based on Machine Learning Methods. in Forests
MDPI., 14(1), 46.
https://doi.org/10.3390/f14010046

Milanović S, Kaczmarowski J, Ciesielski M, Trailović Z, Mielcarek M, Szczygieł R, Kwiatkowski M, Bałazy R, Zasada M, Milanović S. Modeling and Mapping of Forest Fire Occurrence in the Lower Silesian Voivodeship of Poland Based on Machine Learning Methods. in Forests. 2023;14(1):46.
doi:10.3390/f14010046 .

Milanović, Slobodan, Kaczmarowski, Jan, Ciesielski, Mariusz, Trailović, Zoran, Mielcarek, Miłosz, Szczygieł, Ryszard, Kwiatkowski, Mirosław, Bałazy, Radomir, Zasada, Michał, Milanović, Slađan, "Modeling and Mapping of Forest Fire Occurrence in the Lower Silesian Voivodeship of Poland Based on Machine Learning Methods" in Forests, 14, no. 1 (2023):46,
https://doi.org/10.3390/f14010046 . .

TY  - JOUR
AU  - Milanović, Slobodan
AU  - Mihailović, Dragutin
AU  - Lakićević, Milena
AU  - Đurđević, Vladimir
AU  - Malinović-Milićević, Slavica
AU  - Milanović, Slađan
AU  - Trailović, Zoran
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1312
AB  - The impact of climate change on insect pests is an emerging topic in forestry and forest science. This study investigates the relationships between two broadleaved forest pests – spongy moth (Lymantria dispar L.) and brown-tail moth (Euproctis chrysorrhoea L.) – and oaks (Quercus sp.) as their hosts. Oak forests cover almost one-third of the total forest area of Serbia and are ecologicallyvery valuable, but at the same time vulnerable, as being affected in adverse ways by several primary pests and pathogens. Since 1862, Serbia experienced several extremely large outbreaks of spongy moth with more than a hundred thousand hectares completely defoliated each time, while brown-tail moth occurred periodically with a much lower spatial extent. The aim of this research was to investigate the effect of UV radiation (UVR) and air temperature on spongy moth and brown-tail moth in Serbian forests. We used simulations of the coupled regional climate model EBU-POM (Eta Belgrade University-PrincetonOcean Model) for the A1B scenario for the period 2001-2030 as main input and different statistical methods to explore relationships between observations of pest spread and climate change impacts. Our results suggest: (i) increasing the areas affected by spongy moth due to its sensitivity on UVR in May, and (ii) altitudinal spreading of brown-tail moth population up to 800 – 1000 m. This research indicates that in situ forest observations in Serbia are not only affected by climate change, but also by the combined effect of climate on forest pests. For further research, we recommend exploring other forest stressors or dieback phenomena in European forests by applying the same or similar regional climate model dataset.
PB  - Osterreichischer Agrarverlag GmbH
T2  - Forest Science
T2  - Austrian Journal of Forest Science
T1  - Impact of UV radiation and temperature on the spongy moth and the brown-tail moth in Serbia
EP  - 20
IS  - 1
SP  - 1
DO  - 10.53203/fs.2301.1
ER  - 

@article{
author = "Milanović, Slobodan and Mihailović, Dragutin and Lakićević, Milena and Đurđević, Vladimir and Malinović-Milićević, Slavica and Milanović, Slađan and Trailović, Zoran",
year = "2023",
abstract = "The impact of climate change on insect pests is an emerging topic in forestry and forest science. This study investigates the relationships between two broadleaved forest pests – spongy moth (Lymantria dispar L.) and brown-tail moth (Euproctis chrysorrhoea L.) – and oaks (Quercus sp.) as their hosts. Oak forests cover almost one-third of the total forest area of Serbia and are ecologicallyvery valuable, but at the same time vulnerable, as being affected in adverse ways by several primary pests and pathogens. Since 1862, Serbia experienced several extremely large outbreaks of spongy moth with more than a hundred thousand hectares completely defoliated each time, while brown-tail moth occurred periodically with a much lower spatial extent. The aim of this research was to investigate the effect of UV radiation (UVR) and air temperature on spongy moth and brown-tail moth in Serbian forests. We used simulations of the coupled regional climate model EBU-POM (Eta Belgrade University-PrincetonOcean Model) for the A1B scenario for the period 2001-2030 as main input and different statistical methods to explore relationships between observations of pest spread and climate change impacts. Our results suggest: (i) increasing the areas affected by spongy moth due to its sensitivity on UVR in May, and (ii) altitudinal spreading of brown-tail moth population up to 800 – 1000 m. This research indicates that in situ forest observations in Serbia are not only affected by climate change, but also by the combined effect of climate on forest pests. For further research, we recommend exploring other forest stressors or dieback phenomena in European forests by applying the same or similar regional climate model dataset.",
publisher = "Osterreichischer Agrarverlag GmbH",
journal = "Forest Science, Austrian Journal of Forest Science",
title = "Impact of UV radiation and temperature on the spongy moth and the brown-tail moth in Serbia",
pages = "20-1",
number = "1",
doi = "10.53203/fs.2301.1"
}

Milanović, S., Mihailović, D., Lakićević, M., Đurđević, V., Malinović-Milićević, S., Milanović, S.,& Trailović, Z.. (2023). Impact of UV radiation and temperature on the spongy moth and the brown-tail moth in Serbia. in Forest Science
Osterreichischer Agrarverlag GmbH.(1), 1-20.
https://doi.org/10.53203/fs.2301.1

Milanović S, Mihailović D, Lakićević M, Đurđević V, Malinović-Milićević S, Milanović S, Trailović Z. Impact of UV radiation and temperature on the spongy moth and the brown-tail moth in Serbia. in Forest Science. 2023;(1):1-20.
doi:10.53203/fs.2301.1 .

Milanović, Slobodan, Mihailović, Dragutin, Lakićević, Milena, Đurđević, Vladimir, Malinović-Milićević, Slavica, Milanović, Slađan, Trailović, Zoran, "Impact of UV radiation and temperature on the spongy moth and the brown-tail moth in Serbia" in Forest Science, no. 1 (2023):1-20,
https://doi.org/10.53203/fs.2301.1 . .

TY  - JOUR
AU  - Milanović, Slobodan
AU  - Trailović, Zoran
AU  - Milanović, Slađan
AU  - Hochbichler, Eduard
AU  - Kirisits, Thomas
AU  - Immitzer, Markus
AU  - Čermák, Petr
AU  - Pokorný, Radek
AU  - Jankovský, Libor
AU  - Jaafari, Abolfazl
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1315
AB  - Forest fires are becoming a serious concern in Central European countries such as Austria (AT) and the Czech Republic (CZ). Mapping fire ignition probabilities across countries can be a useful tool for fire risk mitigation. This study was conducted to: (i) evaluate the contribution of the variables obtained from open-source datasets (i.e., MODIS, OpenStreetMap, and WorldClim) for modeling fire ignition probability at the country level; and (ii) investigate how well the Random Forest (RF) method performs from one country to another. The importance of the predictors was evaluated using the Gini impurity method, and RF was evaluated using the ROC-AUC and confusion matrix. The most important variables were the topographic wetness index in the AT model and slope in the CZ model. The AUC values in the validation sets were 0.848 (AT model) and 0.717 (CZ model). When the respective models were applied to the entire dataset, they achieved 82.5% (AT model) and 66.4% (CZ model) accuracy. Cross-comparison revealed that the CZ model may be successfully applied to the AT dataset (AUC = 0.808, Acc = 82.5%), while the AT model showed poor explanatory power when applied to the CZ dataset (AUC = 0.582, Acc = 13.6%). Our study provides insights into the effect of the accuracy and completeness of open-source data on the reliability of national-level forest fire probability assessment.
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Sustainability
T2  - Sustainability
T1  - Country-Level Modeling of Forest Fires in Austria and the Czech Republic: Insights from Open-Source Data
IS  - 6
SP  - 5269
VL  - 15
DO  - 10.3390/su15065269
ER  - 

@article{
author = "Milanović, Slobodan and Trailović, Zoran and Milanović, Slađan and Hochbichler, Eduard and Kirisits, Thomas and Immitzer, Markus and Čermák, Petr and Pokorný, Radek and Jankovský, Libor and Jaafari, Abolfazl",
year = "2023",
abstract = "Forest fires are becoming a serious concern in Central European countries such as Austria (AT) and the Czech Republic (CZ). Mapping fire ignition probabilities across countries can be a useful tool for fire risk mitigation. This study was conducted to: (i) evaluate the contribution of the variables obtained from open-source datasets (i.e., MODIS, OpenStreetMap, and WorldClim) for modeling fire ignition probability at the country level; and (ii) investigate how well the Random Forest (RF) method performs from one country to another. The importance of the predictors was evaluated using the Gini impurity method, and RF was evaluated using the ROC-AUC and confusion matrix. The most important variables were the topographic wetness index in the AT model and slope in the CZ model. The AUC values in the validation sets were 0.848 (AT model) and 0.717 (CZ model). When the respective models were applied to the entire dataset, they achieved 82.5% (AT model) and 66.4% (CZ model) accuracy. Cross-comparison revealed that the CZ model may be successfully applied to the AT dataset (AUC = 0.808, Acc = 82.5%), while the AT model showed poor explanatory power when applied to the CZ dataset (AUC = 0.582, Acc = 13.6%). Our study provides insights into the effect of the accuracy and completeness of open-source data on the reliability of national-level forest fire probability assessment.",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Sustainability, Sustainability",
title = "Country-Level Modeling of Forest Fires in Austria and the Czech Republic: Insights from Open-Source Data",
number = "6",
pages = "5269",
volume = "15",
doi = "10.3390/su15065269"
}

Milanović, S., Trailović, Z., Milanović, S., Hochbichler, E., Kirisits, T., Immitzer, M., Čermák, P., Pokorný, R., Jankovský, L.,& Jaafari, A.. (2023). Country-Level Modeling of Forest Fires in Austria and the Czech Republic: Insights from Open-Source Data. in Sustainability
Multidisciplinary Digital Publishing Institute (MDPI)., 15(6), 5269.
https://doi.org/10.3390/su15065269

Milanović S, Trailović Z, Milanović S, Hochbichler E, Kirisits T, Immitzer M, Čermák P, Pokorný R, Jankovský L, Jaafari A. Country-Level Modeling of Forest Fires in Austria and the Czech Republic: Insights from Open-Source Data. in Sustainability. 2023;15(6):5269.
doi:10.3390/su15065269 .

Milanović, Slobodan, Trailović, Zoran, Milanović, Slađan, Hochbichler, Eduard, Kirisits, Thomas, Immitzer, Markus, Čermák, Petr, Pokorný, Radek, Jankovský, Libor, Jaafari, Abolfazl, "Country-Level Modeling of Forest Fires in Austria and the Czech Republic: Insights from Open-Source Data" in Sustainability, 15, no. 6 (2023):5269,
https://doi.org/10.3390/su15065269 . .

TY  - JOUR
AU  - Grujić-Milanović, Jelica
AU  - Rajković, Jovana
AU  - Milanović, Slađan
AU  - Jaćević, Vesna
AU  - Miloradović, Zoran
AU  - Nežić, Lana
AU  - Novaković, Radmila
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1386
AB  - Cardiovascular diseases (CVDs) are a group of diseases with a very high rate of morbidity and mortality. The clinical presentation of CVDs can vary from asymptomatic to classic symptoms such as chest pain in patients with myocardial infarction. Current therapeutics for CVDs mainly target disease symptoms. The most common CVDs are coronary artery disease, acute myocardial infarction, atrial fibrillation, chronic heart failure, arterial hypertension, and valvular heart disease. In their treatment, conventional therapies and pharmacological therapies are used. However, the use of herbal medicines in the therapy of these diseases has also been reported in the literature, resulting in a need for critical evaluation of advances related to their use. Therefore, we carried out a narrative review of pharmacological and herbal therapeutic effects reported for these diseases. Data for this comprehensive review were obtained from electronic databases such as MedLine, PubMed, Web of Science, Scopus, and Google Scholar. Conventional therapy requires an individual approach to the patients, as when patients do not respond well, this often causes allergic effects or various other unwanted effects. Nowadays, medicinal plants as therapeutics are frequently used in different parts of the world. Preclinical/clinical pharmacology studies have confirmed that some bioactive compounds may have beneficial therapeutic effects in some common CVDs. The natural products analyzed in this review are promising phytochemicals for adjuvant and complementary drug candidates in CVDs pharmacotherapy, and some of them have already been approved by the FDA. There are insufficient clinical studies to compare the effectiveness of natural products compared to approved therapeutics for the treatment of CVDs. Further long-term studies are needed to accelerate the potential of using natural products for these diseases. Despite this undoubted beneficence on CVDs, there are no strong breakthroughs supporting the implementation of natural products in clinical practice. Nevertheless, they are promising agents in the supplementation and co-therapy of CVDs.
PB  - MDPI (Multidisciplinary Digital Publishing Institute)
T2  - Antioxidants
T2  - Antioxidants
T1  - Natural Substances vs. Approved Drugs in the Treatment of Main Cardiovascular Disorders—Is There a Breakthrough?
IS  - 12
SP  - 2088
VL  - 12
DO  - 10.3390/antiox12122088
ER  - 

@article{
author = "Grujić-Milanović, Jelica and Rajković, Jovana and Milanović, Slađan and Jaćević, Vesna and Miloradović, Zoran and Nežić, Lana and Novaković, Radmila",
year = "2023",
abstract = "Cardiovascular diseases (CVDs) are a group of diseases with a very high rate of morbidity and mortality. The clinical presentation of CVDs can vary from asymptomatic to classic symptoms such as chest pain in patients with myocardial infarction. Current therapeutics for CVDs mainly target disease symptoms. The most common CVDs are coronary artery disease, acute myocardial infarction, atrial fibrillation, chronic heart failure, arterial hypertension, and valvular heart disease. In their treatment, conventional therapies and pharmacological therapies are used. However, the use of herbal medicines in the therapy of these diseases has also been reported in the literature, resulting in a need for critical evaluation of advances related to their use. Therefore, we carried out a narrative review of pharmacological and herbal therapeutic effects reported for these diseases. Data for this comprehensive review were obtained from electronic databases such as MedLine, PubMed, Web of Science, Scopus, and Google Scholar. Conventional therapy requires an individual approach to the patients, as when patients do not respond well, this often causes allergic effects or various other unwanted effects. Nowadays, medicinal plants as therapeutics are frequently used in different parts of the world. Preclinical/clinical pharmacology studies have confirmed that some bioactive compounds may have beneficial therapeutic effects in some common CVDs. The natural products analyzed in this review are promising phytochemicals for adjuvant and complementary drug candidates in CVDs pharmacotherapy, and some of them have already been approved by the FDA. There are insufficient clinical studies to compare the effectiveness of natural products compared to approved therapeutics for the treatment of CVDs. Further long-term studies are needed to accelerate the potential of using natural products for these diseases. Despite this undoubted beneficence on CVDs, there are no strong breakthroughs supporting the implementation of natural products in clinical practice. Nevertheless, they are promising agents in the supplementation and co-therapy of CVDs.",
publisher = "MDPI (Multidisciplinary Digital Publishing Institute)",
journal = "Antioxidants, Antioxidants",
title = "Natural Substances vs. Approved Drugs in the Treatment of Main Cardiovascular Disorders—Is There a Breakthrough?",
number = "12",
pages = "2088",
volume = "12",
doi = "10.3390/antiox12122088"
}

Grujić-Milanović, J., Rajković, J., Milanović, S., Jaćević, V., Miloradović, Z., Nežić, L.,& Novaković, R.. (2023). Natural Substances vs. Approved Drugs in the Treatment of Main Cardiovascular Disorders—Is There a Breakthrough?. in Antioxidants
MDPI (Multidisciplinary Digital Publishing Institute)., 12(12), 2088.
https://doi.org/10.3390/antiox12122088

Grujić-Milanović J, Rajković J, Milanović S, Jaćević V, Miloradović Z, Nežić L, Novaković R. Natural Substances vs. Approved Drugs in the Treatment of Main Cardiovascular Disorders—Is There a Breakthrough?. in Antioxidants. 2023;12(12):2088.
doi:10.3390/antiox12122088 .

Grujić-Milanović, Jelica, Rajković, Jovana, Milanović, Slađan, Jaćević, Vesna, Miloradović, Zoran, Nežić, Lana, Novaković, Radmila, "Natural Substances vs. Approved Drugs in the Treatment of Main Cardiovascular Disorders—Is There a Breakthrough?" in Antioxidants, 12, no. 12 (2023):2088,
https://doi.org/10.3390/antiox12122088 . .

TY  - JOUR
AU  - Krljanac, Gordana
AU  - Ašanin, Milika
AU  - Mickovski-Katalina, Nataša
AU  - Milanović, Slađan
AU  - Bjekić, Jovana
AU  - Savić, Lidija
AU  - Mitrović, Predrag
AU  - Đurović, Marina
AU  - Vasiljević, Zorana
PY  - 2022
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1236
AB  - Background/Aim.The pharmacoinvasive (PI) therapy is a recommended strategy in patients (pts) with ST elevation myocardial infarction (STEMI) unable to undergo timely primary percutaneous coronary intervention (p-PCI). The aim of the study was to find out the cohorts of pts who are not treated by any reperfusion therapy (RT) as well to determine the outcome of the pts treated with RT in a transition country without fully applicable PI therapy. Methods. The study analyzed data from the Hospital National Registry for Acute Coronary Syndrome of Serbia (HORACS). Results. The significant predictors of the withdrawing of the application of any RT in the model [c 75.6%, SE 0.004, 95% CI 0.748-0.761)] were age (≥ 65 years), heart failure (Killip II-IV), diabetes mellitus, and the time to first medical contact (FMC) (> 360 min). In patients without RT, mortality was 15.7%, in pts treated with fibrinolytic therapy (FT) was 10.5%, and in pts treated with pPCI, it was 6.2% (p < 0.000). Within 3 hours to FMC, higher in-hospital mortality was in FT pts (FT 8.7% vs p-PCI 4.3%). FT treated patients were older, had more comorbidities and heart failure (HF). However, after propensity score matching, in order to adjust the differences among the pts, the mortality rate remained higher in FT pts but not statistically significantly higher than in p-PCI pts (FT 8.8% vs p-PCI 6.4%). Conclusion. The balance of the best cost-benefit strategies for better use of RT is difficult to achieve in transition countries. The possibility for timely p-PCI and PI therapy is especially not applicable in high-risk patients, older pts, pts with HF, and those with diabetes mellitus.
AB  - Uvod/Cilj. Preporuke za lečenje bolesnika sa akutnim infarktom miokarda sa elevacijom ST segmenta (STEMI), nalažu da se kod bolesnika koji ne mogu blagovremeno da odu na primarnu perkutanu intervenciju (p-PCI) primeni farmakoinvazivna (FI) strategija lečenja. Cilj rada bio je da se utvrde karakteristike bolesnika koji se uopšte ne leče reperfuzionom terapijom (RT), kao i da se analizira ishod lečenja pomoću RT, u zemlji u tranziciji u kojoj mreža za primenu FI terapije nije u potpunosti razvijena. Metode. Za istraživanje su korišćeni podaci bolničkog Nacionalnog registra za akutni koronarni sindrom Srbije (HORACS). Rezultati. Značajni prediktori za izostanak primene RT su prikazani u modelu (c 75,6%, SE0,004, 95% CI 0,748–0,761) u koji su uključene godine starosti (≥ 65), srčana insuficijencija (Killip klasa II-IV), dijabetes melitus, i vreme do prvog medicinskog kontakta (PMK) (> 360min). Kod bolesnika koji nisu bili lečeni RT, mortalitet je bio 15,7%, kod bolesnika lečenih fibrinolitičkom terapijom (FT) iznosio je 10,5%, a kod bolesnika lečenih p-PCI 6,2% ( p <0,000). U grupi bolesnika koji su do PMK stizali za 3 sata, mortalitet lečenih pomoću FT bio je veći od mortaliteta bolesnika lečenih p-PCI (FT 8,7% vs p-PCI 4,3%). Bolesnici lečeni pomoću FT bili su stariji, sa više komorbiditeta i sa učestalijim znacima srčane insuficijencije. Ipak, posle primenjenog propensity skora, sa ciljem da se izbegnu razlike između dve grupe bolesnika, mortalitet u FT grupi ostao je veći, alibez statistički značajne razlike u odnosu na bolesnike lečene p-PCI (FT 8,8%. vs p-PCI 6,4%). Zaključak. Primena RT, uz postignuti idealan balans potrošnje i koristi, teško je izvodljiva u zemljama u tranziciji. Mogućnosti za blagovremenu primenu p-PCI, kao i FIterapije, posebno su ograničene kod visoko rizičnih, starijih bolesnika, kod bolesnika sa znacima srčane insuficijencije, komorbiditetima i dijabetesom melitusom.
PB  - Military Medical Academy, INI
T2  - Vojnosanitetski Pregled
T1  - The use of reperfusion therapy in transition countries without fully applicable pharmacoinvasive strategy
EP  - 229
IS  - 3
SP  - 221
VL  - 79
DO  - 10.2298/VSP190118090K
ER  - 

@article{
author = "Krljanac, Gordana and Ašanin, Milika and Mickovski-Katalina, Nataša and Milanović, Slađan and Bjekić, Jovana and Savić, Lidija and Mitrović, Predrag and Đurović, Marina and Vasiljević, Zorana",
year = "2022",
abstract = "Background/Aim.The pharmacoinvasive (PI) therapy is a recommended strategy in patients (pts) with ST elevation myocardial infarction (STEMI) unable to undergo timely primary percutaneous coronary intervention (p-PCI). The aim of the study was to find out the cohorts of pts who are not treated by any reperfusion therapy (RT) as well to determine the outcome of the pts treated with RT in a transition country without fully applicable PI therapy. Methods. The study analyzed data from the Hospital National Registry for Acute Coronary Syndrome of Serbia (HORACS). Results. The significant predictors of the withdrawing of the application of any RT in the model [c 75.6%, SE 0.004, 95% CI 0.748-0.761)] were age (≥ 65 years), heart failure (Killip II-IV), diabetes mellitus, and the time to first medical contact (FMC) (> 360 min). In patients without RT, mortality was 15.7%, in pts treated with fibrinolytic therapy (FT) was 10.5%, and in pts treated with pPCI, it was 6.2% (p < 0.000). Within 3 hours to FMC, higher in-hospital mortality was in FT pts (FT 8.7% vs p-PCI 4.3%). FT treated patients were older, had more comorbidities and heart failure (HF). However, after propensity score matching, in order to adjust the differences among the pts, the mortality rate remained higher in FT pts but not statistically significantly higher than in p-PCI pts (FT 8.8% vs p-PCI 6.4%). Conclusion. The balance of the best cost-benefit strategies for better use of RT is difficult to achieve in transition countries. The possibility for timely p-PCI and PI therapy is especially not applicable in high-risk patients, older pts, pts with HF, and those with diabetes mellitus., Uvod/Cilj. Preporuke za lečenje bolesnika sa akutnim infarktom miokarda sa elevacijom ST segmenta (STEMI), nalažu da se kod bolesnika koji ne mogu blagovremeno da odu na primarnu perkutanu intervenciju (p-PCI) primeni farmakoinvazivna (FI) strategija lečenja. Cilj rada bio je da se utvrde karakteristike bolesnika koji se uopšte ne leče reperfuzionom terapijom (RT), kao i da se analizira ishod lečenja pomoću RT, u zemlji u tranziciji u kojoj mreža za primenu FI terapije nije u potpunosti razvijena. Metode. Za istraživanje su korišćeni podaci bolničkog Nacionalnog registra za akutni koronarni sindrom Srbije (HORACS). Rezultati. Značajni prediktori za izostanak primene RT su prikazani u modelu (c 75,6%, SE0,004, 95% CI 0,748–0,761) u koji su uključene godine starosti (≥ 65), srčana insuficijencija (Killip klasa II-IV), dijabetes melitus, i vreme do prvog medicinskog kontakta (PMK) (> 360min). Kod bolesnika koji nisu bili lečeni RT, mortalitet je bio 15,7%, kod bolesnika lečenih fibrinolitičkom terapijom (FT) iznosio je 10,5%, a kod bolesnika lečenih p-PCI 6,2% ( p <0,000). U grupi bolesnika koji su do PMK stizali za 3 sata, mortalitet lečenih pomoću FT bio je veći od mortaliteta bolesnika lečenih p-PCI (FT 8,7% vs p-PCI 4,3%). Bolesnici lečeni pomoću FT bili su stariji, sa više komorbiditeta i sa učestalijim znacima srčane insuficijencije. Ipak, posle primenjenog propensity skora, sa ciljem da se izbegnu razlike između dve grupe bolesnika, mortalitet u FT grupi ostao je veći, alibez statistički značajne razlike u odnosu na bolesnike lečene p-PCI (FT 8,8%. vs p-PCI 6,4%). Zaključak. Primena RT, uz postignuti idealan balans potrošnje i koristi, teško je izvodljiva u zemljama u tranziciji. Mogućnosti za blagovremenu primenu p-PCI, kao i FIterapije, posebno su ograničene kod visoko rizičnih, starijih bolesnika, kod bolesnika sa znacima srčane insuficijencije, komorbiditetima i dijabetesom melitusom.",
publisher = "Military Medical Academy, INI",
journal = "Vojnosanitetski Pregled",
title = "The use of reperfusion therapy in transition countries without fully applicable pharmacoinvasive strategy",
pages = "229-221",
number = "3",
volume = "79",
doi = "10.2298/VSP190118090K"
}

Krljanac, G., Ašanin, M., Mickovski-Katalina, N., Milanović, S., Bjekić, J., Savić, L., Mitrović, P., Đurović, M.,& Vasiljević, Z.. (2022). The use of reperfusion therapy in transition countries without fully applicable pharmacoinvasive strategy. in Vojnosanitetski Pregled
Military Medical Academy, INI., 79(3), 221-229.
https://doi.org/10.2298/VSP190118090K

Krljanac G, Ašanin M, Mickovski-Katalina N, Milanović S, Bjekić J, Savić L, Mitrović P, Đurović M, Vasiljević Z. The use of reperfusion therapy in transition countries without fully applicable pharmacoinvasive strategy. in Vojnosanitetski Pregled. 2022;79(3):221-229.
doi:10.2298/VSP190118090K .

Krljanac, Gordana, Ašanin, Milika, Mickovski-Katalina, Nataša, Milanović, Slađan, Bjekić, Jovana, Savić, Lidija, Mitrović, Predrag, Đurović, Marina, Vasiljević, Zorana, "The use of reperfusion therapy in transition countries without fully applicable pharmacoinvasive strategy" in Vojnosanitetski Pregled, 79, no. 3 (2022):221-229,
https://doi.org/10.2298/VSP190118090K . .

TY  - JOUR
AU  - Grujić-Milanović, Jelica
AU  - Jaćević, Vesna
AU  - Miloradović, Zoran
AU  - Milanović, Slađan
AU  - Jovović, Đurđica
AU  - Ivanov, Milan
AU  - Karanović, Danijela
AU  - Vajić, Una Jovana
AU  - Mihailović-Stanojević, Nevena
PY  - 2022
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1263
AB  - Objective Background: The main cause of death among patients with malignant hypertension is a kidney failure. The promising field in essential and malignant hypertension therapy could be centered on the amelioration of oxidative stress using antioxidant molecules like resveratrol. Resveratrol is a potent antioxidative agent naturally occurred in many plants that possess health-promoting properties. Methods: In the present study, we investigated the therapeutic potential of resveratrol, a polyphenol with anti-oxidative activity, in NG-L-Arginine Methyl Ester (L-NAME) treated spontaneously hypertensive rats (SHR) - malignantly hypertensive rats (MHR). Results: Resveratrol significantly improves oxidative damages by modulation of antioxidant enzymes and suppression of prooxidant factors in the kidney tissue of MHR. Enhanced antioxidant defense in the kidney improves renal function and ameliorates the morphological changes in this target organ. Besides, protective properties of resveratrol are followed by the restoration of the nitrogen oxide (NO) pathway. 4) Conclusion: Antioxidant therapy with resveratrol could represent promising therapeutical approach in hypertension, especially malignant, against kidney damage.
T2  - Biomedicine & Pharmacotherapy
T1  - Resveratrol improved kidney function and structure in malignantly hypertensive rats by restoration of antioxidant capacity and nitric oxide bioavailability
SP  - 113642
VL  - 154
DO  - 10.1016/j.biopha.2022.113642
ER  - 

@article{
author = "Grujić-Milanović, Jelica and Jaćević, Vesna and Miloradović, Zoran and Milanović, Slađan and Jovović, Đurđica and Ivanov, Milan and Karanović, Danijela and Vajić, Una Jovana and Mihailović-Stanojević, Nevena",
year = "2022",
abstract = "Objective Background: The main cause of death among patients with malignant hypertension is a kidney failure. The promising field in essential and malignant hypertension therapy could be centered on the amelioration of oxidative stress using antioxidant molecules like resveratrol. Resveratrol is a potent antioxidative agent naturally occurred in many plants that possess health-promoting properties. Methods: In the present study, we investigated the therapeutic potential of resveratrol, a polyphenol with anti-oxidative activity, in NG-L-Arginine Methyl Ester (L-NAME) treated spontaneously hypertensive rats (SHR) - malignantly hypertensive rats (MHR). Results: Resveratrol significantly improves oxidative damages by modulation of antioxidant enzymes and suppression of prooxidant factors in the kidney tissue of MHR. Enhanced antioxidant defense in the kidney improves renal function and ameliorates the morphological changes in this target organ. Besides, protective properties of resveratrol are followed by the restoration of the nitrogen oxide (NO) pathway. 4) Conclusion: Antioxidant therapy with resveratrol could represent promising therapeutical approach in hypertension, especially malignant, against kidney damage.",
journal = "Biomedicine & Pharmacotherapy",
title = "Resveratrol improved kidney function and structure in malignantly hypertensive rats by restoration of antioxidant capacity and nitric oxide bioavailability",
pages = "113642",
volume = "154",
doi = "10.1016/j.biopha.2022.113642"
}

Grujić-Milanović, J., Jaćević, V., Miloradović, Z., Milanović, S., Jovović, Đ., Ivanov, M., Karanović, D., Vajić, U. J.,& Mihailović-Stanojević, N.. (2022). Resveratrol improved kidney function and structure in malignantly hypertensive rats by restoration of antioxidant capacity and nitric oxide bioavailability. in Biomedicine & Pharmacotherapy, 154, 113642.
https://doi.org/10.1016/j.biopha.2022.113642

Grujić-Milanović J, Jaćević V, Miloradović Z, Milanović S, Jovović Đ, Ivanov M, Karanović D, Vajić UJ, Mihailović-Stanojević N. Resveratrol improved kidney function and structure in malignantly hypertensive rats by restoration of antioxidant capacity and nitric oxide bioavailability. in Biomedicine & Pharmacotherapy. 2022;154:113642.
doi:10.1016/j.biopha.2022.113642 .

Grujić-Milanović, Jelica, Jaćević, Vesna, Miloradović, Zoran, Milanović, Slađan, Jovović, Đurđica, Ivanov, Milan, Karanović, Danijela, Vajić, Una Jovana, Mihailović-Stanojević, Nevena, "Resveratrol improved kidney function and structure in malignantly hypertensive rats by restoration of antioxidant capacity and nitric oxide bioavailability" in Biomedicine & Pharmacotherapy, 154 (2022):113642,
https://doi.org/10.1016/j.biopha.2022.113642 . .

TY  - JOUR
AU  - Vulić, Katarina
AU  - Bjekić, Jovana
AU  - Paunović, Dunja
AU  - Jovanović, Miloš
AU  - Milanović, Slađan
AU  - Filipović, Saša
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1087
AB  - Associative memory (AM) reflects the ability to remember and retrieve multiple pieces of information bound together thus enabling complex episodic experiences. Despite growing interest in the use of transcranial direct current stimulation (tDCS) for the modulation of AM, there are inconsistent evidence regarding its benefits. An alternative to standard constant tDCS could be the application of frequency-modulated tDCS protocols, that mimic natural function-relevant brain rhythms. Here, we show the effects of anodal tDCS oscillating in theta rhythm (5 Hz; 1.5 ± 0.1 mA) versus constant anodal tDCS and sham over left posterior parietal cortex on cued recall of face-word associations. In a crossover design, each participant completed AM assessment immediately following 20-min theta-oscillatory, constant, and sham tDCS, as well as 1 and 5 days after. Theta oscillatory tDCS increased initial AM performance in comparison to sham, and so did constant tDCS. On the group level, no differences between oscillatory and constant tDCS were observed, but individual-level analysis revealed that some participants responded to theta-oscillatory but not to constant tDCS, and vice versa, which could be attributed to their different physiological modes of action. This study shows the potential of oscillatory tDCS protocols for memory enhancement to produce strong and reliable memory-modulating effects which deserve to be investigated further.
T2  - Scientific Reports
T1  - Theta-modulated oscillatory transcranial direct current stimulation over posterior parietal cortex improves associative memory
IS  - 1
SP  - 3013
VL  - 11
DO  - 10.1038/s41598-021-82577-7
ER  - 

@article{
author = "Vulić, Katarina and Bjekić, Jovana and Paunović, Dunja and Jovanović, Miloš and Milanović, Slađan and Filipović, Saša",
year = "2021",
abstract = "Associative memory (AM) reflects the ability to remember and retrieve multiple pieces of information bound together thus enabling complex episodic experiences. Despite growing interest in the use of transcranial direct current stimulation (tDCS) for the modulation of AM, there are inconsistent evidence regarding its benefits. An alternative to standard constant tDCS could be the application of frequency-modulated tDCS protocols, that mimic natural function-relevant brain rhythms. Here, we show the effects of anodal tDCS oscillating in theta rhythm (5 Hz; 1.5 ± 0.1 mA) versus constant anodal tDCS and sham over left posterior parietal cortex on cued recall of face-word associations. In a crossover design, each participant completed AM assessment immediately following 20-min theta-oscillatory, constant, and sham tDCS, as well as 1 and 5 days after. Theta oscillatory tDCS increased initial AM performance in comparison to sham, and so did constant tDCS. On the group level, no differences between oscillatory and constant tDCS were observed, but individual-level analysis revealed that some participants responded to theta-oscillatory but not to constant tDCS, and vice versa, which could be attributed to their different physiological modes of action. This study shows the potential of oscillatory tDCS protocols for memory enhancement to produce strong and reliable memory-modulating effects which deserve to be investigated further.",
journal = "Scientific Reports",
title = "Theta-modulated oscillatory transcranial direct current stimulation over posterior parietal cortex improves associative memory",
number = "1",
pages = "3013",
volume = "11",
doi = "10.1038/s41598-021-82577-7"
}

Vulić, K., Bjekić, J., Paunović, D., Jovanović, M., Milanović, S.,& Filipović, S.. (2021). Theta-modulated oscillatory transcranial direct current stimulation over posterior parietal cortex improves associative memory. in Scientific Reports, 11(1), 3013.
https://doi.org/10.1038/s41598-021-82577-7

Vulić K, Bjekić J, Paunović D, Jovanović M, Milanović S, Filipović S. Theta-modulated oscillatory transcranial direct current stimulation over posterior parietal cortex improves associative memory. in Scientific Reports. 2021;11(1):3013.
doi:10.1038/s41598-021-82577-7 .

Vulić, Katarina, Bjekić, Jovana, Paunović, Dunja, Jovanović, Miloš, Milanović, Slađan, Filipović, Saša, "Theta-modulated oscillatory transcranial direct current stimulation over posterior parietal cortex improves associative memory" in Scientific Reports, 11, no. 1 (2021):3013,
https://doi.org/10.1038/s41598-021-82577-7 . .

TY  - JOUR
AU  - Filipović, Saša
AU  - Kačar, Aleksandra
AU  - Milanović, Slađan
AU  - Ljubisavljević, Miloš
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1194
AB  - Background: Although dopaminergic medication has been the foundation of Parkinson's disease (PD) therapy for decades, sensitive and specific therapeutic response biomarkers that allow for better treatment optimization are lacking. Objective: We tested whether the features of Transcranial Magnetic Stimulation-based neurophysiological measures taken off-medication are associated with dopaminergic medication-induced clinical effects. Method: Motor cortex excitability [short-latency intracortical inhibition (SICI), intracortical facilitation (ICF), short-latency afferent inhibition (SAI), and input-output (IO) curve], and plasticity [paired associative stimulation (PAS) protocol] neurophysiological measures were examined in 23 PD patients off-medication. Clinical features were quantified by the motor section of the Unified Parkinson's Disease Scale (total score and lateralized total, bradykinesia, and rigidity sub-scores), and the differences between measures off-medication and on-medication (following the usual morning dose), were determined. Total daily dopaminergic medication dose (expressed as levodopa equivalent daily dose-LEDD), was also determined. Results: SICI significantly correlated with changes in lateralized UPDRS motor and bradykinesia sub-scores, suggesting that patients with stronger basal intracortical inhibition benefit more from dopaminergic treatment than patients with weaker intracortical inhibition. Also, ICF significantly negatively correlated with LEDD, suggesting that patients with stronger intracortical facilitation require less dopaminergic medication to achieve optimal therapeutic benefit. Both associations were independent of disease severity and duration. Conclusions: The results suggest variability of (patho) physiological phenotypes related to intracortical inhibitory and facilitatory mechanisms determining clinical response to dopaminergic medication in PD. Measures of intracortical excitability may help predict patients' response to dopaminergic therapy, thus potentially providing a background for developing personalized therapy in PD.
PB  - Frontiers Media S.A.
T2  - Frontiers in Neurology
T1  - Neurophysiological Predictors of Response to Medication in Parkinson's Disease
SP  - 763911
VL  - 12
DO  - 10.3389/fneur.2021.763911
ER  - 

@article{
author = "Filipović, Saša and Kačar, Aleksandra and Milanović, Slađan and Ljubisavljević, Miloš",
year = "2021",
abstract = "Background: Although dopaminergic medication has been the foundation of Parkinson's disease (PD) therapy for decades, sensitive and specific therapeutic response biomarkers that allow for better treatment optimization are lacking. Objective: We tested whether the features of Transcranial Magnetic Stimulation-based neurophysiological measures taken off-medication are associated with dopaminergic medication-induced clinical effects. Method: Motor cortex excitability [short-latency intracortical inhibition (SICI), intracortical facilitation (ICF), short-latency afferent inhibition (SAI), and input-output (IO) curve], and plasticity [paired associative stimulation (PAS) protocol] neurophysiological measures were examined in 23 PD patients off-medication. Clinical features were quantified by the motor section of the Unified Parkinson's Disease Scale (total score and lateralized total, bradykinesia, and rigidity sub-scores), and the differences between measures off-medication and on-medication (following the usual morning dose), were determined. Total daily dopaminergic medication dose (expressed as levodopa equivalent daily dose-LEDD), was also determined. Results: SICI significantly correlated with changes in lateralized UPDRS motor and bradykinesia sub-scores, suggesting that patients with stronger basal intracortical inhibition benefit more from dopaminergic treatment than patients with weaker intracortical inhibition. Also, ICF significantly negatively correlated with LEDD, suggesting that patients with stronger intracortical facilitation require less dopaminergic medication to achieve optimal therapeutic benefit. Both associations were independent of disease severity and duration. Conclusions: The results suggest variability of (patho) physiological phenotypes related to intracortical inhibitory and facilitatory mechanisms determining clinical response to dopaminergic medication in PD. Measures of intracortical excitability may help predict patients' response to dopaminergic therapy, thus potentially providing a background for developing personalized therapy in PD.",
publisher = "Frontiers Media S.A.",
journal = "Frontiers in Neurology",
title = "Neurophysiological Predictors of Response to Medication in Parkinson's Disease",
pages = "763911",
volume = "12",
doi = "10.3389/fneur.2021.763911"
}

Filipović, S., Kačar, A., Milanović, S.,& Ljubisavljević, M.. (2021). Neurophysiological Predictors of Response to Medication in Parkinson's Disease. in Frontiers in Neurology
Frontiers Media S.A.., 12, 763911.
https://doi.org/10.3389/fneur.2021.763911

Filipović S, Kačar A, Milanović S, Ljubisavljević M. Neurophysiological Predictors of Response to Medication in Parkinson's Disease. in Frontiers in Neurology. 2021;12:763911.
doi:10.3389/fneur.2021.763911 .

Filipović, Saša, Kačar, Aleksandra, Milanović, Slađan, Ljubisavljević, Miloš, "Neurophysiological Predictors of Response to Medication in Parkinson's Disease" in Frontiers in Neurology, 12 (2021):763911,
https://doi.org/10.3389/fneur.2021.763911 . .

TY  - JOUR
AU  - Milanović, Slobodan
AU  - Marković, Nenad
AU  - Pamucar, Dragan
AU  - Gigović, Ljubomir
AU  - Kostić, Pavle
AU  - Milanović, Slađan
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1077
AB  - Forest fire risk has increased globally during the previous decades. The Mediterranean region is traditionally the most at risk in Europe, but continental countries like Serbia have experienced significant economic and ecological losses due to forest fires. To prevent damage to forests and infrastructure, alongside other societal losses, it is necessary to create an effective protection system against fire, which minimizes the harmful effects. Forest fire probability mapping, as one of the basic tools in risk management, allows the allocation of resources for fire suppression, within a fire season, from zones with a lower risk to those under higher threat. Logistic regression (LR) has been used as a standard procedure in forest fire probability mapping, but in the last decade, machine learning methods such as fandom forest (RF) have become more frequent. The main goals in this study were to (i) determine the main explanatory variables for forest fire occurrence for both models, LR and RF, and (ii) map the probability of forest fire occurrence in Eastern Serbia based on LR and RF. The most important variable was drought code, followed by different anthropogenic features depending on the type of the model. The RF models demonstrated better overall predictive ability than LR models. The map produced may increase firefighting efficiency due to the early detection of forest fire and enable resources to be allocated in the eastern part of Serbia, which covers more than one-third of the country's area.
PB  - MDPI
T2  - Forests
T1  - Forest Fire Probability Mapping in Eastern Serbia: Logistic Regression versus Random Forest Method
IS  - 1
SP  - 5
VL  - 12
DO  - 10.3390/f12010005
ER  - 

@article{
author = "Milanović, Slobodan and Marković, Nenad and Pamucar, Dragan and Gigović, Ljubomir and Kostić, Pavle and Milanović, Slađan",
year = "2021",
abstract = "Forest fire risk has increased globally during the previous decades. The Mediterranean region is traditionally the most at risk in Europe, but continental countries like Serbia have experienced significant economic and ecological losses due to forest fires. To prevent damage to forests and infrastructure, alongside other societal losses, it is necessary to create an effective protection system against fire, which minimizes the harmful effects. Forest fire probability mapping, as one of the basic tools in risk management, allows the allocation of resources for fire suppression, within a fire season, from zones with a lower risk to those under higher threat. Logistic regression (LR) has been used as a standard procedure in forest fire probability mapping, but in the last decade, machine learning methods such as fandom forest (RF) have become more frequent. The main goals in this study were to (i) determine the main explanatory variables for forest fire occurrence for both models, LR and RF, and (ii) map the probability of forest fire occurrence in Eastern Serbia based on LR and RF. The most important variable was drought code, followed by different anthropogenic features depending on the type of the model. The RF models demonstrated better overall predictive ability than LR models. The map produced may increase firefighting efficiency due to the early detection of forest fire and enable resources to be allocated in the eastern part of Serbia, which covers more than one-third of the country's area.",
publisher = "MDPI",
journal = "Forests",
title = "Forest Fire Probability Mapping in Eastern Serbia: Logistic Regression versus Random Forest Method",
number = "1",
pages = "5",
volume = "12",
doi = "10.3390/f12010005"
}

Milanović, S., Marković, N., Pamucar, D., Gigović, L., Kostić, P.,& Milanović, S.. (2021). Forest Fire Probability Mapping in Eastern Serbia: Logistic Regression versus Random Forest Method. in Forests
MDPI., 12(1), 5.
https://doi.org/10.3390/f12010005

Milanović S, Marković N, Pamucar D, Gigović L, Kostić P, Milanović S. Forest Fire Probability Mapping in Eastern Serbia: Logistic Regression versus Random Forest Method. in Forests. 2021;12(1):5.
doi:10.3390/f12010005 .

Milanović, Slobodan, Marković, Nenad, Pamucar, Dragan, Gigović, Ljubomir, Kostić, Pavle, Milanović, Slađan, "Forest Fire Probability Mapping in Eastern Serbia: Logistic Regression versus Random Forest Method" in Forests, 12, no. 1 (2021):5,
https://doi.org/10.3390/f12010005 . .

TY  - JOUR
AU  - Grujić-Milanović, Jelica
AU  - Jaćević, Vesna
AU  - Miloradović, Zoran
AU  - Jovović, Đurđica
AU  - Milosavljević, Ivica
AU  - Milanović, Slađan
AU  - Mihailović-Stanojević, Nevena
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1137
AB  - Hypertension is one of the most prevalent and powerful contributors of cardiovascular diseases. Malignant hypertension is a relatively rare but extremely severe form of hypertension accompanied with heart, brain, and renal impairment. Resveratrol, a recently described grape-derived, polyphenolic antioxidant molecule, has been proposed as an effective agent in the prevention of cardiovascular diseases. This study was designed to examine chronic resveratrol administration on blood pressure, oxidative stress, and inflammation, with special emphasis on cardiac structure and function in two models of experimental hypertension. The experiments were performed in spontaneously (SHRs) and malignantly hypertensive rats (MHRs). The chronic administration of resveratrol significantly decreased blood pressure in both spontaneously and malignant hypertensive animals. The resveratrol treatment ameliorated morphological changes in the heart tissue. The immunohistochemistry of the heart tissue after resveratrol treatment showed that both TGF-β and Bax were not present in the myocytes of SHRs and were present mainly in the myocytes of MHRs. Resveratrol suppressed lipid peroxidation and significantly improved oxidative status and release of NO. These results suggest that resveratrol prevents hypertrophic and apoptotic consequences induced by high blood pressure with more pronounced effects in malignant hypertension.
PB  - MDPI
T2  - International Journal of Molecular Sciences
T1  - Resveratrol Protects Cardiac Tissue in Experimental Malignant Hypertension Due to Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Properties
IS  - 9
SP  - 5006
VL  - 22
DO  - 10.3390/ijms22095006
ER  - 

@article{
author = "Grujić-Milanović, Jelica and Jaćević, Vesna and Miloradović, Zoran and Jovović, Đurđica and Milosavljević, Ivica and Milanović, Slađan and Mihailović-Stanojević, Nevena",
year = "2021",
abstract = "Hypertension is one of the most prevalent and powerful contributors of cardiovascular diseases. Malignant hypertension is a relatively rare but extremely severe form of hypertension accompanied with heart, brain, and renal impairment. Resveratrol, a recently described grape-derived, polyphenolic antioxidant molecule, has been proposed as an effective agent in the prevention of cardiovascular diseases. This study was designed to examine chronic resveratrol administration on blood pressure, oxidative stress, and inflammation, with special emphasis on cardiac structure and function in two models of experimental hypertension. The experiments were performed in spontaneously (SHRs) and malignantly hypertensive rats (MHRs). The chronic administration of resveratrol significantly decreased blood pressure in both spontaneously and malignant hypertensive animals. The resveratrol treatment ameliorated morphological changes in the heart tissue. The immunohistochemistry of the heart tissue after resveratrol treatment showed that both TGF-β and Bax were not present in the myocytes of SHRs and were present mainly in the myocytes of MHRs. Resveratrol suppressed lipid peroxidation and significantly improved oxidative status and release of NO. These results suggest that resveratrol prevents hypertrophic and apoptotic consequences induced by high blood pressure with more pronounced effects in malignant hypertension.",
publisher = "MDPI",
journal = "International Journal of Molecular Sciences",
title = "Resveratrol Protects Cardiac Tissue in Experimental Malignant Hypertension Due to Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Properties",
number = "9",
pages = "5006",
volume = "22",
doi = "10.3390/ijms22095006"
}

Grujić-Milanović, J., Jaćević, V., Miloradović, Z., Jovović, Đ., Milosavljević, I., Milanović, S.,& Mihailović-Stanojević, N.. (2021). Resveratrol Protects Cardiac Tissue in Experimental Malignant Hypertension Due to Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Properties. in International Journal of Molecular Sciences
MDPI., 22(9), 5006.
https://doi.org/10.3390/ijms22095006

Grujić-Milanović J, Jaćević V, Miloradović Z, Jovović Đ, Milosavljević I, Milanović S, Mihailović-Stanojević N. Resveratrol Protects Cardiac Tissue in Experimental Malignant Hypertension Due to Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Properties. in International Journal of Molecular Sciences. 2021;22(9):5006.
doi:10.3390/ijms22095006 .

Grujić-Milanović, Jelica, Jaćević, Vesna, Miloradović, Zoran, Jovović, Đurđica, Milosavljević, Ivica, Milanović, Slađan, Mihailović-Stanojević, Nevena, "Resveratrol Protects Cardiac Tissue in Experimental Malignant Hypertension Due to Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Properties" in International Journal of Molecular Sciences, 22, no. 9 (2021):5006,
https://doi.org/10.3390/ijms22095006 . .

TY  - CONF
AU  - Filipović, Saša
AU  - Knežević, T.
AU  - Rodić, S.
AU  - Milanović, Slađan
AU  - Drulović, Jelena
AU  - Konstantinović, Ljubica
PY  - 2020
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1065
PB  - Wiley, Hoboken
C3  - European Journal of Neurology
T1  - Reliability of H-reflex as a paraclinical measure in neurorehabilitation of progressive multiple sclerosis patients with leg spasticity and gait problems
EP  - 1016
SP  - 1016
VL  - 27
UR  - https://hdl.handle.net/21.15107/rcub_rimi_1065
ER  - 

@conference{
author = "Filipović, Saša and Knežević, T. and Rodić, S. and Milanović, Slađan and Drulović, Jelena and Konstantinović, Ljubica",
year = "2020",
publisher = "Wiley, Hoboken",
journal = "European Journal of Neurology",
title = "Reliability of H-reflex as a paraclinical measure in neurorehabilitation of progressive multiple sclerosis patients with leg spasticity and gait problems",
pages = "1016-1016",
volume = "27",
url = "https://hdl.handle.net/21.15107/rcub_rimi_1065"
}

Filipović, S., Knežević, T., Rodić, S., Milanović, S., Drulović, J.,& Konstantinović, L.. (2020). Reliability of H-reflex as a paraclinical measure in neurorehabilitation of progressive multiple sclerosis patients with leg spasticity and gait problems. in European Journal of Neurology
Wiley, Hoboken., 27, 1016-1016.
https://hdl.handle.net/21.15107/rcub_rimi_1065

Filipović S, Knežević T, Rodić S, Milanović S, Drulović J, Konstantinović L. Reliability of H-reflex as a paraclinical measure in neurorehabilitation of progressive multiple sclerosis patients with leg spasticity and gait problems. in European Journal of Neurology. 2020;27:1016-1016.
https://hdl.handle.net/21.15107/rcub_rimi_1065 .

Filipović, Saša, Knežević, T., Rodić, S., Milanović, Slađan, Drulović, Jelena, Konstantinović, Ljubica, "Reliability of H-reflex as a paraclinical measure in neurorehabilitation of progressive multiple sclerosis patients with leg spasticity and gait problems" in European Journal of Neurology, 27 (2020):1016-1016,
https://hdl.handle.net/21.15107/rcub_rimi_1065 .

TY  - JOUR
AU  - Stevanović, Vuk
AU  - Jelić, Milan
AU  - Milanović, Slađan
AU  - Filipović, Saša
AU  - Mikić, Mladen J.
AU  - Stojanović, Marko D. M.
PY  - 2019
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/918
AB  - The purpose of this study was to examine the acute effects of static stretching (SS) and dynamic stretching (DS), alone and in combination with specific basketball warm-up (SBWU), on the neuromuscular excitability and vertical jump height in basketball players. Twelve healthy young male basketball players participated in the study (18 +/- 0.42 years; 17.4 - 18.6 age range; 188 +/- 9 cm; 76.5 +/- 9 kg). All participants completed two different stretching treatments (static and dynamic), performed on different days at least seven days apart, in the same period of training microcycle, in a counterbalanced order. Each session consisted of a self-paced jogging warm-up, followed by a 10-minute testing period (T0), which involved eliciting H reflex and M waves, followed by three trials of a vertical jump test. Participants then performed one of the treatment protocols. After another test (T1), participants conducted 8-minute specific basketball warm-up and then one more test (T2). Combined 3 (time) x 2 (stretching protocol) analysis of variance with repeated measures on both factors revealed that SS significantly decreased spinal excitability (H/M ratio) (p = 0.015, d = -0.38, percentage of change = -20.55%) and vertical jump height (p = 0.007, d = -1.91, percentage of change = -2.6%), but after SBWU, vertical jump height increased (p = 0.006, d = 1.13, percentage of change = 3.01%), while H/M ratio continued decreasing (p = 0.019, d = -0.45, percentage of change = -30.23%). Acute effects of DS, alone and in combination with SBWU were not significant. It seems that SBWU attenuates negative acute effects of SS on vertical jump performance in young basketball players, while DS appears to cause no significant acute effect for this population.
PB  - Journal Sports Science & Medicine, Bursa
T2  - Journal of Sports Science & Medicine
T1  - Sport-Specific Warm-Up Attenuates Static Stretching-Induced Negative Effects on Vertical Jump But Not Neuromuscular Excitability in Basketball Players
EP  - 289
IS  - 2
SP  - 282
VL  - 18
UR  - https://hdl.handle.net/21.15107/rcub_rimi_918
ER  - 

@article{
author = "Stevanović, Vuk and Jelić, Milan and Milanović, Slađan and Filipović, Saša and Mikić, Mladen J. and Stojanović, Marko D. M.",
year = "2019",
abstract = "The purpose of this study was to examine the acute effects of static stretching (SS) and dynamic stretching (DS), alone and in combination with specific basketball warm-up (SBWU), on the neuromuscular excitability and vertical jump height in basketball players. Twelve healthy young male basketball players participated in the study (18 +/- 0.42 years; 17.4 - 18.6 age range; 188 +/- 9 cm; 76.5 +/- 9 kg). All participants completed two different stretching treatments (static and dynamic), performed on different days at least seven days apart, in the same period of training microcycle, in a counterbalanced order. Each session consisted of a self-paced jogging warm-up, followed by a 10-minute testing period (T0), which involved eliciting H reflex and M waves, followed by three trials of a vertical jump test. Participants then performed one of the treatment protocols. After another test (T1), participants conducted 8-minute specific basketball warm-up and then one more test (T2). Combined 3 (time) x 2 (stretching protocol) analysis of variance with repeated measures on both factors revealed that SS significantly decreased spinal excitability (H/M ratio) (p = 0.015, d = -0.38, percentage of change = -20.55%) and vertical jump height (p = 0.007, d = -1.91, percentage of change = -2.6%), but after SBWU, vertical jump height increased (p = 0.006, d = 1.13, percentage of change = 3.01%), while H/M ratio continued decreasing (p = 0.019, d = -0.45, percentage of change = -30.23%). Acute effects of DS, alone and in combination with SBWU were not significant. It seems that SBWU attenuates negative acute effects of SS on vertical jump performance in young basketball players, while DS appears to cause no significant acute effect for this population.",
publisher = "Journal Sports Science & Medicine, Bursa",
journal = "Journal of Sports Science & Medicine",
title = "Sport-Specific Warm-Up Attenuates Static Stretching-Induced Negative Effects on Vertical Jump But Not Neuromuscular Excitability in Basketball Players",
pages = "289-282",
number = "2",
volume = "18",
url = "https://hdl.handle.net/21.15107/rcub_rimi_918"
}

Stevanović, V., Jelić, M., Milanović, S., Filipović, S., Mikić, M. J.,& Stojanović, M. D. M.. (2019). Sport-Specific Warm-Up Attenuates Static Stretching-Induced Negative Effects on Vertical Jump But Not Neuromuscular Excitability in Basketball Players. in Journal of Sports Science & Medicine
Journal Sports Science & Medicine, Bursa., 18(2), 282-289.
https://hdl.handle.net/21.15107/rcub_rimi_918

Stevanović V, Jelić M, Milanović S, Filipović S, Mikić MJ, Stojanović MDM. Sport-Specific Warm-Up Attenuates Static Stretching-Induced Negative Effects on Vertical Jump But Not Neuromuscular Excitability in Basketball Players. in Journal of Sports Science & Medicine. 2019;18(2):282-289.
https://hdl.handle.net/21.15107/rcub_rimi_918 .

Stevanović, Vuk, Jelić, Milan, Milanović, Slađan, Filipović, Saša, Mikić, Mladen J., Stojanović, Marko D. M., "Sport-Specific Warm-Up Attenuates Static Stretching-Induced Negative Effects on Vertical Jump But Not Neuromuscular Excitability in Basketball Players" in Journal of Sports Science & Medicine, 18, no. 2 (2019):282-289,
https://hdl.handle.net/21.15107/rcub_rimi_918 .

TY  - JOUR
AU  - Bjekić, Jovana
AU  - Čolić, Marija V.
AU  - Živanović, Marko
AU  - Milanović, Slađan
AU  - Filipović, Saša
PY  - 2019
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/943
AB  - Associative memory plays a key role in everyday functioning, but it declines with normal ageing as well as due to various pathological states and conditions, thus impairing quality of life. Associative memory enhancement via neurostimulation over frontal areas resulted in limited success, while posterior stimulation sites seemed to be more promising. We hypothesized that anodal transcranial direct current stimulation (tDCS) of parietal areas would lead to higher performance in associative memory due to high connectivity between posterior parietal cortex (PPC) and hippocampus. Forty-two healthy adults participated in two sham-controlled cross-over experiments. Anodal electrode (20 min, 1.5 mA) was placed over P3 in Experiment 1 and over P4 in Experiment 2. During tDCS participants played a simple computer game. After each stimulation session, participants completed parallel forms of an associative memory task (Experiment 1: face-word memory; Experiment 2: object-location memory) and a control task (verbal fluency). In both experiments, associative memory was improved after anodal stimulation compared to sham stimulation, while no differences were observed in the control task. Additionally, memory performance was higher in the second than in the first trial, but the increase in performance between the two trials did not differ between stimulation conditions. It can be concluded that a single-session anodal tDCS over posterior parietal cortex can improve associative memory performance. The specificity, robustness, and reproducibility of the effect suggest that PPC is a promising target for brain stimulation aiming to enhance memory functions.
PB  - Academic Press Inc Elsevier Science, San Diego
T2  - Neurobiology of Learning & Memory
T1  - Transcranial direct current stimulation (tDCS) over parietal cortex improves associative memory
EP  - 120
SP  - 114
VL  - 157
DO  - 10.1016/j.nlm.2018.12.007
ER  - 

@article{
author = "Bjekić, Jovana and Čolić, Marija V. and Živanović, Marko and Milanović, Slađan and Filipović, Saša",
year = "2019",
abstract = "Associative memory plays a key role in everyday functioning, but it declines with normal ageing as well as due to various pathological states and conditions, thus impairing quality of life. Associative memory enhancement via neurostimulation over frontal areas resulted in limited success, while posterior stimulation sites seemed to be more promising. We hypothesized that anodal transcranial direct current stimulation (tDCS) of parietal areas would lead to higher performance in associative memory due to high connectivity between posterior parietal cortex (PPC) and hippocampus. Forty-two healthy adults participated in two sham-controlled cross-over experiments. Anodal electrode (20 min, 1.5 mA) was placed over P3 in Experiment 1 and over P4 in Experiment 2. During tDCS participants played a simple computer game. After each stimulation session, participants completed parallel forms of an associative memory task (Experiment 1: face-word memory; Experiment 2: object-location memory) and a control task (verbal fluency). In both experiments, associative memory was improved after anodal stimulation compared to sham stimulation, while no differences were observed in the control task. Additionally, memory performance was higher in the second than in the first trial, but the increase in performance between the two trials did not differ between stimulation conditions. It can be concluded that a single-session anodal tDCS over posterior parietal cortex can improve associative memory performance. The specificity, robustness, and reproducibility of the effect suggest that PPC is a promising target for brain stimulation aiming to enhance memory functions.",
publisher = "Academic Press Inc Elsevier Science, San Diego",
journal = "Neurobiology of Learning & Memory",
title = "Transcranial direct current stimulation (tDCS) over parietal cortex improves associative memory",
pages = "120-114",
volume = "157",
doi = "10.1016/j.nlm.2018.12.007"
}

Bjekić, J., Čolić, M. V., Živanović, M., Milanović, S.,& Filipović, S.. (2019). Transcranial direct current stimulation (tDCS) over parietal cortex improves associative memory. in Neurobiology of Learning & Memory
Academic Press Inc Elsevier Science, San Diego., 157, 114-120.
https://doi.org/10.1016/j.nlm.2018.12.007

Bjekić J, Čolić MV, Živanović M, Milanović S, Filipović S. Transcranial direct current stimulation (tDCS) over parietal cortex improves associative memory. in Neurobiology of Learning & Memory. 2019;157:114-120.
doi:10.1016/j.nlm.2018.12.007 .

Bjekić, Jovana, Čolić, Marija V., Živanović, Marko, Milanović, Slađan, Filipović, Saša, "Transcranial direct current stimulation (tDCS) over parietal cortex improves associative memory" in Neurobiology of Learning & Memory, 157 (2019):114-120,
https://doi.org/10.1016/j.nlm.2018.12.007 . .

TY  - CONF
AU  - Bjekić, Jovana
AU  - Čolić, Marija
AU  - Živanović, Marko
AU  - Milanović, Slađan
AU  - Filipović, Saša
PY  - 2018
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/891
PB  - Wiley, Hoboken
C3  - European Journal of Neurology
T1  - Transcranial Direct Current Stimulation (tDCS) over lateral parietal cortex facilitates object-location and face-word associative memory
EP  - 67
SP  - 67
VL  - 25
UR  - https://hdl.handle.net/21.15107/rcub_rimi_891
ER  - 

@conference{
author = "Bjekić, Jovana and Čolić, Marija and Živanović, Marko and Milanović, Slađan and Filipović, Saša",
year = "2018",
publisher = "Wiley, Hoboken",
journal = "European Journal of Neurology",
title = "Transcranial Direct Current Stimulation (tDCS) over lateral parietal cortex facilitates object-location and face-word associative memory",
pages = "67-67",
volume = "25",
url = "https://hdl.handle.net/21.15107/rcub_rimi_891"
}

Bjekić, J., Čolić, M., Živanović, M., Milanović, S.,& Filipović, S.. (2018). Transcranial Direct Current Stimulation (tDCS) over lateral parietal cortex facilitates object-location and face-word associative memory. in European Journal of Neurology
Wiley, Hoboken., 25, 67-67.
https://hdl.handle.net/21.15107/rcub_rimi_891

Bjekić J, Čolić M, Živanović M, Milanović S, Filipović S. Transcranial Direct Current Stimulation (tDCS) over lateral parietal cortex facilitates object-location and face-word associative memory. in European Journal of Neurology. 2018;25:67-67.
https://hdl.handle.net/21.15107/rcub_rimi_891 .

Bjekić, Jovana, Čolić, Marija, Živanović, Marko, Milanović, Slađan, Filipović, Saša, "Transcranial Direct Current Stimulation (tDCS) over lateral parietal cortex facilitates object-location and face-word associative memory" in European Journal of Neurology, 25 (2018):67-67,
https://hdl.handle.net/21.15107/rcub_rimi_891 .

TY  - CONF
AU  - Jovanović, Miloš D.
AU  - Despotović, Željko V.
AU  - Tajdić, Marko R.
AU  - Milanović, Slađan
PY  - 2018
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/881
AB  - In the paper will be described a control system of a dry ice cleaning system. One such cleaner can be used in various branches of industry such as: electrical, metal, wood, automotive, food, pharmaceutical, plastics, paper and cosmetics industries. It can also be used in printing, steelworks and for removing graphite from the walls by removing impurities and not damaging the substrate material. The dry ice cleaner is characterized by the appropriate speed, flow and vibrations that need to be generated. The cleaner should be robust and have a wide range of operating temperatures. There is a very necessary protection from static electricity, which is easily generated by constant vibration and friction, which can very badly affect, and even lead to the failure of the entire control system. The software of this control system is protected from external influence by WDT, Watch Dog Timer. Also, the software is written so that it can recognize improper handling by a cleaner. In case of improper handling, the software will protect the user.
C3  - 2018 17th International Symposium on INFOTEH-JAHORINA, INFOTEH 2018 - Proceedings
T1  - Control system for portable dry ice cleaning device
EP  - 4
SP  - 1
VL  - 2018-January
DO  - 10.1109/INFOTEH.2018.8345551
ER  - 

@conference{
author = "Jovanović, Miloš D. and Despotović, Željko V. and Tajdić, Marko R. and Milanović, Slađan",
year = "2018",
abstract = "In the paper will be described a control system of a dry ice cleaning system. One such cleaner can be used in various branches of industry such as: electrical, metal, wood, automotive, food, pharmaceutical, plastics, paper and cosmetics industries. It can also be used in printing, steelworks and for removing graphite from the walls by removing impurities and not damaging the substrate material. The dry ice cleaner is characterized by the appropriate speed, flow and vibrations that need to be generated. The cleaner should be robust and have a wide range of operating temperatures. There is a very necessary protection from static electricity, which is easily generated by constant vibration and friction, which can very badly affect, and even lead to the failure of the entire control system. The software of this control system is protected from external influence by WDT, Watch Dog Timer. Also, the software is written so that it can recognize improper handling by a cleaner. In case of improper handling, the software will protect the user.",
journal = "2018 17th International Symposium on INFOTEH-JAHORINA, INFOTEH 2018 - Proceedings",
title = "Control system for portable dry ice cleaning device",
pages = "4-1",
volume = "2018-January",
doi = "10.1109/INFOTEH.2018.8345551"
}

Jovanović, M. D., Despotović, Ž. V., Tajdić, M. R.,& Milanović, S.. (2018). Control system for portable dry ice cleaning device. in 2018 17th International Symposium on INFOTEH-JAHORINA, INFOTEH 2018 - Proceedings, 2018-January, 1-4.
https://doi.org/10.1109/INFOTEH.2018.8345551

Jovanović MD, Despotović ŽV, Tajdić MR, Milanović S. Control system for portable dry ice cleaning device. in 2018 17th International Symposium on INFOTEH-JAHORINA, INFOTEH 2018 - Proceedings. 2018;2018-January:1-4.
doi:10.1109/INFOTEH.2018.8345551 .

Jovanović, Miloš D., Despotović, Željko V., Tajdić, Marko R., Milanović, Slađan, "Control system for portable dry ice cleaning device" in 2018 17th International Symposium on INFOTEH-JAHORINA, INFOTEH 2018 - Proceedings, 2018-January (2018):1-4,
https://doi.org/10.1109/INFOTEH.2018.8345551 . .

TY  - JOUR
AU  - Dominović-Kovačević, Aleksandra
AU  - Račić, Duško
AU  - Grgić, Sanja
AU  - Vukojević, Zoran
AU  - Milanović, Slađan
AU  - Ilić, Tihomir V.
PY  - 2018
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/901
AB  - Diagnosis of amyotrophic lateral sclerosis (ALS) is based on combination of clinical signs and electrophysiological correlates of pathological process which takes place in general. New electrophysiological criteria Awaji-Shima (AS) additionally qualify the complex fasciculations and neurogenically modified potentials of motor units as signs of active lesions of peripheral motor neuron, contrary to previously valid revised El Escorial criteria (rEE). The objective of this research was to determine the clinical significance and advantages of using the AS criteria in patients with ALS. Methods. Thirty patients (59.2 ± 10.9 years, 57% of them with spinal form of the disease) with clinically suspected ALS were monitored from the time of diagnosis until reaching the category of definitive diagnosis or death. The clinical evaluation and electromyographic (EMG) examinations were carried out at 3-month intervals. Results. By applying the AS criteria, the category of probable or definite diagnosis was achieved in all patients with ALS, except in one (96.6%), as contrary to the rEE (33.3%), after 6 months of the follow-up period. The subclinical affection in more than two body regions has been defined through detection of denervation potentials (80% of the patients by using the AS, or 67% by the rEE criteria). The complex fasciculations were registered particularly often in small muscles of the feet (37- 40%). Conclusion. Application of the AS criteria improve the achievment of category of probable or definite diagnosis of ALS by 2.7 months earlier compared to the rEE. This outcome is particularly affected by a higher frequency of positive EMG findings, when the AS criteria were employed. Early determination of diagnosis provides the better perspective and more frequent participation of the ALS patients in pharmacotherapy studies intended to establish new therapeutic options.
AB  - Dijagnoza amiotrofične lateralne skleroze (LS) zasniva se na kombinaciji kliničkih znakova i elektrofizioloških korelata patološkog procesa koji se odvija u osnovi. Novi elektrofiziološki kriterijumi, Awaji-Shima (AS), dodatno kvalifikuju kompleksne fascikulacije i neurogeno izmenjene potencijale motornih jedinica kao znakove aktivnih lezija perifernog motornog neurona, nasuprot ranije važećim revidiranim El Escorial kriterijumima (rEE). Cilj ovog istraživanja bio je da se utvrdi klinički značaj i prednosti primene AS kriterijuma, kod obolelih od ALS. Metode. 30 bolesnika (59,2 ± 10,9 godina, od kojih 57% sa spinalnom formom bolesti) sa klinički suspektnom ALS, praćeno je od vremena postavljanja dijagnoze do postizanja kategorije definitivne dijagnoze ili smrtnog ishoda. Kod bolesnika su obavljane klinička evaluacija i elektromiografski (EMG) pregledi u tromesečnim intervalima. Rezultati. Primjenom AS kriterijuma, nakon 6 meseci praćenja, kategorija verovatne ili pouzdane dijagnoze postignuta je kod svih bolesnika sa ALS, izuzev jednog (96,6%), nasuprot rEE kriterijuma (33.3%). EMG nalazi bili su pozitivni u ≥ 2 telesna regiona kod 80% bolesnika primenom AS, odnosno 67% primenom rEE. Kompleksne fascikulacije zabeležene su posebno učestalo u malim mišićima stopala (37-40%). Zaključak. Primenom AS kriterijuma kategorija vjerovatne ili pouzdane dijagnoze ALS postiže se za 2,7 meseca ranije, u poređenju sa rEE, na šta posebno utiče veća učestalost pozitivnih EMG nalaza. Ranije utvrđivanje dijagnoze donosi perspektivu veće zastupljenosti obolelih u farmakoterapijskim studijama sa novim terapeutskim agensima.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Comparison of diagnostic criteria in patients with amyotrophic lateral sclerosis: The contribution of electromyographic findings
T1  - Poređenje dijagnostičkih kriterijuma kod bolesnika sa amiotrofičnom lateralnom sklerozom - doprinos elektromiografskih nalaza
EP  - 446
IS  - 5
SP  - 439
VL  - 75
DO  - 10.2298/VSP160115330D
ER  - 

@article{
author = "Dominović-Kovačević, Aleksandra and Račić, Duško and Grgić, Sanja and Vukojević, Zoran and Milanović, Slađan and Ilić, Tihomir V.",
year = "2018",
abstract = "Diagnosis of amyotrophic lateral sclerosis (ALS) is based on combination of clinical signs and electrophysiological correlates of pathological process which takes place in general. New electrophysiological criteria Awaji-Shima (AS) additionally qualify the complex fasciculations and neurogenically modified potentials of motor units as signs of active lesions of peripheral motor neuron, contrary to previously valid revised El Escorial criteria (rEE). The objective of this research was to determine the clinical significance and advantages of using the AS criteria in patients with ALS. Methods. Thirty patients (59.2 ± 10.9 years, 57% of them with spinal form of the disease) with clinically suspected ALS were monitored from the time of diagnosis until reaching the category of definitive diagnosis or death. The clinical evaluation and electromyographic (EMG) examinations were carried out at 3-month intervals. Results. By applying the AS criteria, the category of probable or definite diagnosis was achieved in all patients with ALS, except in one (96.6%), as contrary to the rEE (33.3%), after 6 months of the follow-up period. The subclinical affection in more than two body regions has been defined through detection of denervation potentials (80% of the patients by using the AS, or 67% by the rEE criteria). The complex fasciculations were registered particularly often in small muscles of the feet (37- 40%). Conclusion. Application of the AS criteria improve the achievment of category of probable or definite diagnosis of ALS by 2.7 months earlier compared to the rEE. This outcome is particularly affected by a higher frequency of positive EMG findings, when the AS criteria were employed. Early determination of diagnosis provides the better perspective and more frequent participation of the ALS patients in pharmacotherapy studies intended to establish new therapeutic options., Dijagnoza amiotrofične lateralne skleroze (LS) zasniva se na kombinaciji kliničkih znakova i elektrofizioloških korelata patološkog procesa koji se odvija u osnovi. Novi elektrofiziološki kriterijumi, Awaji-Shima (AS), dodatno kvalifikuju kompleksne fascikulacije i neurogeno izmenjene potencijale motornih jedinica kao znakove aktivnih lezija perifernog motornog neurona, nasuprot ranije važećim revidiranim El Escorial kriterijumima (rEE). Cilj ovog istraživanja bio je da se utvrdi klinički značaj i prednosti primene AS kriterijuma, kod obolelih od ALS. Metode. 30 bolesnika (59,2 ± 10,9 godina, od kojih 57% sa spinalnom formom bolesti) sa klinički suspektnom ALS, praćeno je od vremena postavljanja dijagnoze do postizanja kategorije definitivne dijagnoze ili smrtnog ishoda. Kod bolesnika su obavljane klinička evaluacija i elektromiografski (EMG) pregledi u tromesečnim intervalima. Rezultati. Primjenom AS kriterijuma, nakon 6 meseci praćenja, kategorija verovatne ili pouzdane dijagnoze postignuta je kod svih bolesnika sa ALS, izuzev jednog (96,6%), nasuprot rEE kriterijuma (33.3%). EMG nalazi bili su pozitivni u ≥ 2 telesna regiona kod 80% bolesnika primenom AS, odnosno 67% primenom rEE. Kompleksne fascikulacije zabeležene su posebno učestalo u malim mišićima stopala (37-40%). Zaključak. Primenom AS kriterijuma kategorija vjerovatne ili pouzdane dijagnoze ALS postiže se za 2,7 meseca ranije, u poređenju sa rEE, na šta posebno utiče veća učestalost pozitivnih EMG nalaza. Ranije utvrđivanje dijagnoze donosi perspektivu veće zastupljenosti obolelih u farmakoterapijskim studijama sa novim terapeutskim agensima.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Comparison of diagnostic criteria in patients with amyotrophic lateral sclerosis: The contribution of electromyographic findings, Poređenje dijagnostičkih kriterijuma kod bolesnika sa amiotrofičnom lateralnom sklerozom - doprinos elektromiografskih nalaza",
pages = "446-439",
number = "5",
volume = "75",
doi = "10.2298/VSP160115330D"
}

Dominović-Kovačević, A., Račić, D., Grgić, S., Vukojević, Z., Milanović, S.,& Ilić, T. V.. (2018). Comparison of diagnostic criteria in patients with amyotrophic lateral sclerosis: The contribution of electromyographic findings. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 75(5), 439-446.
https://doi.org/10.2298/VSP160115330D

Dominović-Kovačević A, Račić D, Grgić S, Vukojević Z, Milanović S, Ilić TV. Comparison of diagnostic criteria in patients with amyotrophic lateral sclerosis: The contribution of electromyographic findings. in Vojnosanitetski pregled. 2018;75(5):439-446.
doi:10.2298/VSP160115330D .

Dominović-Kovačević, Aleksandra, Račić, Duško, Grgić, Sanja, Vukojević, Zoran, Milanović, Slađan, Ilić, Tihomir V., "Comparison of diagnostic criteria in patients with amyotrophic lateral sclerosis: The contribution of electromyographic findings" in Vojnosanitetski pregled, 75, no. 5 (2018):439-446,
https://doi.org/10.2298/VSP160115330D . .

TY  - JOUR
AU  - Kačar, Aleksandra
AU  - Milanović, Slađan
AU  - Filipović, Saša
AU  - Ljubisavljević, Miloš
PY  - 2017
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/792
AB  - Paired associative stimulation (PAS) combines repetitive peripheral nerve stimulation with motor cortex (M1) transcranial magnetic stimulation (TMS), to induce plastic-like changes of cortical excitability. While much attention has been dedicated to post-PAS effects little is known about processes during PAS. We compared the time-course of changes in M1 excitability during standard facilitatory PAS intervention among patients with Parkinsons disease (PD), known to have diminished post-PAS response, and healthy subjects. Compared to baseline pre-PAS MEPs, conditioned MEPs during PAS decreased significantly in both groups. The decrease was significantly larger in healthy subjects than in PD patients, regardless whether patients were drug-naive or not. Although post-PAS excitability increase was also larger in healthy subjects than in PD patients, there was no significant correlation between the two phenomena, i.e. the extent of MEP decrease during PAS and the extent of the post-PAS excitability increase. The results highlight an apparent physiological paradox that repetitive application of an inhibitory stimulation pattern leads to subsequent prolonged facilitation, thus broadening the understanding of the phenomenology of PAS response. Results also suggest that in PD cortical circuits involved in conveying inhibition during PAS, are impaired at the clinical onset of the disease and are not influenced by subsequent PD treatment.
PB  - Elsevier Ireland Ltd, Clare
T2  - Neuroscience Research
T1  - Changes in cortical excitability during paired associative stimulation in Parkinson's disease patients and healthy subjects
EP  - 56
SP  - 51
VL  - 124
DO  - 10.1016/j.neures.2017.06.001
ER  - 

@article{
author = "Kačar, Aleksandra and Milanović, Slađan and Filipović, Saša and Ljubisavljević, Miloš",
year = "2017",
abstract = "Paired associative stimulation (PAS) combines repetitive peripheral nerve stimulation with motor cortex (M1) transcranial magnetic stimulation (TMS), to induce plastic-like changes of cortical excitability. While much attention has been dedicated to post-PAS effects little is known about processes during PAS. We compared the time-course of changes in M1 excitability during standard facilitatory PAS intervention among patients with Parkinsons disease (PD), known to have diminished post-PAS response, and healthy subjects. Compared to baseline pre-PAS MEPs, conditioned MEPs during PAS decreased significantly in both groups. The decrease was significantly larger in healthy subjects than in PD patients, regardless whether patients were drug-naive or not. Although post-PAS excitability increase was also larger in healthy subjects than in PD patients, there was no significant correlation between the two phenomena, i.e. the extent of MEP decrease during PAS and the extent of the post-PAS excitability increase. The results highlight an apparent physiological paradox that repetitive application of an inhibitory stimulation pattern leads to subsequent prolonged facilitation, thus broadening the understanding of the phenomenology of PAS response. Results also suggest that in PD cortical circuits involved in conveying inhibition during PAS, are impaired at the clinical onset of the disease and are not influenced by subsequent PD treatment.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Neuroscience Research",
title = "Changes in cortical excitability during paired associative stimulation in Parkinson's disease patients and healthy subjects",
pages = "56-51",
volume = "124",
doi = "10.1016/j.neures.2017.06.001"
}

Kačar, A., Milanović, S., Filipović, S.,& Ljubisavljević, M.. (2017). Changes in cortical excitability during paired associative stimulation in Parkinson's disease patients and healthy subjects. in Neuroscience Research
Elsevier Ireland Ltd, Clare., 124, 51-56.
https://doi.org/10.1016/j.neures.2017.06.001

Kačar A, Milanović S, Filipović S, Ljubisavljević M. Changes in cortical excitability during paired associative stimulation in Parkinson's disease patients and healthy subjects. in Neuroscience Research. 2017;124:51-56.
doi:10.1016/j.neures.2017.06.001 .

Kačar, Aleksandra, Milanović, Slađan, Filipović, Saša, Ljubisavljević, Miloš, "Changes in cortical excitability during paired associative stimulation in Parkinson's disease patients and healthy subjects" in Neuroscience Research, 124 (2017):51-56,
https://doi.org/10.1016/j.neures.2017.06.001 . .

TY  - JOUR
AU  - Jelić, Milan
AU  - Filipović, Saša
AU  - Milanović, Slađan
AU  - Stevanović, Vuk
AU  - Konstantinović, Ljubica
PY  - 2017
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/822
AB  - Objective: To check whether bilateral sequential stimulation (BSS) of M1 with theta burst stimulation (TBS), using facilitatory protocol over non-dominant M1 followed by inhibitory one over dominant M1, can improve skilled task performance with non-dominant hand more than either of the unilateral stimulations do. Both, direct motor cortex (M1) facilitatory non-invasive brain stimulation (NIBS) and contralateral M1 inhibitory NIBS were shown to improve motor learning. Methods: Forty right-handed healthy subjects were divided into 4 matched groups which received either ipsilateral facilitatory (intermittent TBS [iTBS] over non-dominant M1), contralateral inhibitory (continuous TBS [cTBS] over dominant M1), bilateral sequential (contralateral cTBS followed by ipsilateral iTBS), or placebo stimulation. Performance was evaluated by Purdue peg-board test (PPT), before (T0), immediately after (T1), and 30 min after (T2) an intervention. Results: In all groups and for both hands, the PPT scores increased at T1 and T2 in comparison to T0, showing clear learning effect. However, for the target non-dominant hand only, immediately after BSS (at T1) the PPT scores improved significantly more than after either of unilateral interventions or placebo. Conclusion: M1 BSS TBS is an effective intervention for improving motor performance. Significance: M1 BSS TBS seems as a promising tool for motor learning improvement with potential uses in neurorehabilitation.
PB  - Elsevier Ireland Ltd, Clare
T2  - Clinical Neurophysiology
T1  - Bilateral sequential motor cortex stimulation and skilled task performance with non-dominant hand
EP  - 822
IS  - 5
SP  - 814
VL  - 128
DO  - 10.1016/j.clinph.2017.02.020
ER  - 

@article{
author = "Jelić, Milan and Filipović, Saša and Milanović, Slađan and Stevanović, Vuk and Konstantinović, Ljubica",
year = "2017",
abstract = "Objective: To check whether bilateral sequential stimulation (BSS) of M1 with theta burst stimulation (TBS), using facilitatory protocol over non-dominant M1 followed by inhibitory one over dominant M1, can improve skilled task performance with non-dominant hand more than either of the unilateral stimulations do. Both, direct motor cortex (M1) facilitatory non-invasive brain stimulation (NIBS) and contralateral M1 inhibitory NIBS were shown to improve motor learning. Methods: Forty right-handed healthy subjects were divided into 4 matched groups which received either ipsilateral facilitatory (intermittent TBS [iTBS] over non-dominant M1), contralateral inhibitory (continuous TBS [cTBS] over dominant M1), bilateral sequential (contralateral cTBS followed by ipsilateral iTBS), or placebo stimulation. Performance was evaluated by Purdue peg-board test (PPT), before (T0), immediately after (T1), and 30 min after (T2) an intervention. Results: In all groups and for both hands, the PPT scores increased at T1 and T2 in comparison to T0, showing clear learning effect. However, for the target non-dominant hand only, immediately after BSS (at T1) the PPT scores improved significantly more than after either of unilateral interventions or placebo. Conclusion: M1 BSS TBS is an effective intervention for improving motor performance. Significance: M1 BSS TBS seems as a promising tool for motor learning improvement with potential uses in neurorehabilitation.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Clinical Neurophysiology",
title = "Bilateral sequential motor cortex stimulation and skilled task performance with non-dominant hand",
pages = "822-814",
number = "5",
volume = "128",
doi = "10.1016/j.clinph.2017.02.020"
}

Jelić, M., Filipović, S., Milanović, S., Stevanović, V.,& Konstantinović, L.. (2017). Bilateral sequential motor cortex stimulation and skilled task performance with non-dominant hand. in Clinical Neurophysiology
Elsevier Ireland Ltd, Clare., 128(5), 814-822.
https://doi.org/10.1016/j.clinph.2017.02.020

Jelić M, Filipović S, Milanović S, Stevanović V, Konstantinović L. Bilateral sequential motor cortex stimulation and skilled task performance with non-dominant hand. in Clinical Neurophysiology. 2017;128(5):814-822.
doi:10.1016/j.clinph.2017.02.020 .

Jelić, Milan, Filipović, Saša, Milanović, Slađan, Stevanović, Vuk, Konstantinović, Ljubica, "Bilateral sequential motor cortex stimulation and skilled task performance with non-dominant hand" in Clinical Neurophysiology, 128, no. 5 (2017):814-822,
https://doi.org/10.1016/j.clinph.2017.02.020 . .

TY  - JOUR
AU  - Spasojević, Sofija
AU  - Ilić, Tihomir V.
AU  - Milanović, Slađan
AU  - Potkonjak, Veljko
AU  - Rodić, Aleksandar
AU  - Santos-Victor, Jose
PY  - 2017
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/799
AB  - Background: Traditional rehabilitation sessions are often a slow, tedious, disempowering and non-motivational process, supported by clinical assessment tools, i.e. evaluation scales that are prone to subjective rating and imprecise interpretation of patient's performance. Poor patient motivation and insufficient accuracy are thus critical factors that can be improved by new sensing/processing technologies. Objectives: We aim to develop a portable and affordable system, suitable for home re-habilitation, which combines vision-based and wearable sensors. We introduce a novel approach for examining and characterizing the rehabilitation movements, using quantitative descriptors. We propose new Movement Performance Indicators (MPIs) that are extracted directly from sensor data and quantify the symmetry, velocity, and acceleration of the movement of different body/hand parts, and that can potentially be used by therapists for diagnosis and progress assessment. Methods: First, a set of rehabilitation exercises is defined, with the supervision of neurologists and therapists for the specific case of Parkinson's disease. It comprises full-body movements measured with a Kinect device and fine hand movements, acquired with a data glove. Then, the sensor data is used to compute 25 Movement Performance Indicators, to assist the diagnosis and progress monitoring (assessing the disease stage) in Parkinson's disease. A kinematic hand model is developed for data verification and as an additional resource for extracting supplementary movement information. Results: Our results show that the proposed Movement Performance Indicators are relevant for the Parkinson's disease assessment. This is further confirmed by correlation of the proposed indicators with clinical tapping test and UPDRS clinical scale. Classification results showed the potential of these indicators to discriminate between the patients and controls, as well as between the stages that characterize the evolution of the disease. Conclusions: The proposed sensor system, along with the developed approach for rehabilitation movement analysis have a significant potential to support and advance traditional rehabilitation therapy. The main impact of our work is two-fold: (i) the proposition of an approach for supporting the therapists during the diagnosis and monitoring evaluations by reducing subjectivity and imprecision, and (ii) offering the possibility of the system to be used at home for rehabilitation exercises in between sessions with doctors and therapists.
PB  - Georg Thieme Verlag Kg, Stuttgart
T2  - Methods of Information in Medicine
T1  - Combined Vision and Wearable Sensors-based System for Movement Analysis in Rehabilitation
EP  - 111
IS  - 2
SP  - 95
VL  - 56
DO  - 10.3414/ME16-02-0013
ER  - 

@article{
author = "Spasojević, Sofija and Ilić, Tihomir V. and Milanović, Slađan and Potkonjak, Veljko and Rodić, Aleksandar and Santos-Victor, Jose",
year = "2017",
abstract = "Background: Traditional rehabilitation sessions are often a slow, tedious, disempowering and non-motivational process, supported by clinical assessment tools, i.e. evaluation scales that are prone to subjective rating and imprecise interpretation of patient's performance. Poor patient motivation and insufficient accuracy are thus critical factors that can be improved by new sensing/processing technologies. Objectives: We aim to develop a portable and affordable system, suitable for home re-habilitation, which combines vision-based and wearable sensors. We introduce a novel approach for examining and characterizing the rehabilitation movements, using quantitative descriptors. We propose new Movement Performance Indicators (MPIs) that are extracted directly from sensor data and quantify the symmetry, velocity, and acceleration of the movement of different body/hand parts, and that can potentially be used by therapists for diagnosis and progress assessment. Methods: First, a set of rehabilitation exercises is defined, with the supervision of neurologists and therapists for the specific case of Parkinson's disease. It comprises full-body movements measured with a Kinect device and fine hand movements, acquired with a data glove. Then, the sensor data is used to compute 25 Movement Performance Indicators, to assist the diagnosis and progress monitoring (assessing the disease stage) in Parkinson's disease. A kinematic hand model is developed for data verification and as an additional resource for extracting supplementary movement information. Results: Our results show that the proposed Movement Performance Indicators are relevant for the Parkinson's disease assessment. This is further confirmed by correlation of the proposed indicators with clinical tapping test and UPDRS clinical scale. Classification results showed the potential of these indicators to discriminate between the patients and controls, as well as between the stages that characterize the evolution of the disease. Conclusions: The proposed sensor system, along with the developed approach for rehabilitation movement analysis have a significant potential to support and advance traditional rehabilitation therapy. The main impact of our work is two-fold: (i) the proposition of an approach for supporting the therapists during the diagnosis and monitoring evaluations by reducing subjectivity and imprecision, and (ii) offering the possibility of the system to be used at home for rehabilitation exercises in between sessions with doctors and therapists.",
publisher = "Georg Thieme Verlag Kg, Stuttgart",
journal = "Methods of Information in Medicine",
title = "Combined Vision and Wearable Sensors-based System for Movement Analysis in Rehabilitation",
pages = "111-95",
number = "2",
volume = "56",
doi = "10.3414/ME16-02-0013"
}

Spasojević, S., Ilić, T. V., Milanović, S., Potkonjak, V., Rodić, A.,& Santos-Victor, J.. (2017). Combined Vision and Wearable Sensors-based System for Movement Analysis in Rehabilitation. in Methods of Information in Medicine
Georg Thieme Verlag Kg, Stuttgart., 56(2), 95-111.
https://doi.org/10.3414/ME16-02-0013

Spasojević S, Ilić TV, Milanović S, Potkonjak V, Rodić A, Santos-Victor J. Combined Vision and Wearable Sensors-based System for Movement Analysis in Rehabilitation. in Methods of Information in Medicine. 2017;56(2):95-111.
doi:10.3414/ME16-02-0013 .

Spasojević, Sofija, Ilić, Tihomir V., Milanović, Slađan, Potkonjak, Veljko, Rodić, Aleksandar, Santos-Victor, Jose, "Combined Vision and Wearable Sensors-based System for Movement Analysis in Rehabilitation" in Methods of Information in Medicine, 56, no. 2 (2017):95-111,
https://doi.org/10.3414/ME16-02-0013 . .

TY  - JOUR
AU  - Drljačić, Dragana
AU  - Pajić, Sanja
AU  - Nedeljković, Aleksandar
AU  - Milanović, Slađan
AU  - Ilić, Tihomir V.
PY  - 2017
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/810
AB  - Background/Aim. Adaptive control and fingertip force synchronization of precise grasp stability during unimanual manipulation of small objects represents an illustrative example of highly fractionated movements that are foundation of fine motor control. It is assumed that this process is controlled by several motor areas of the frontal lobe, particularly applicable to the primary motor (M-1) and dorsal premotor cortex (PMd). Aiming to examine the role of PMd during fine coordination of fingertip forces we applied theta burst repetitive magnetic stimulation (TBS) to disrupt neural processing in that cortical area. Methods. Using a single-blind, randomized, crossover design, 10 healthy subjects (29 ± 3.9 years) received single sessions of continuous TBS (cTBS600), intermittent TBS (iTBS600), or sham stimulation, separate from one another at least one week, over the PMd region of dominant hemisphere. Precision grasp and lift were assessed by instrumented device, recording grip (G) and load (L) forces, during three manipulation tasks (ramp-and-hold, oscillation force producing and simple lifting tasks), with each hand separately, before and after interventions. Results. We observed the improvement of task performance related to constant error (CE) in oscillation task with the dominant hand (DH) after the iTBS (p = 0.009). On the contrary, the cTBS reduced variable error (VE) for non-dominant hand (NH), p = 0.005. Considering force coordination we found that iTBS worsened variables for NH (G/L ratio, p = 0.017; cross-correlation of the G and L, p = 0.047; Gain, p = 0.047). Conclusion. These results demonstrate the ability of TBS to modulate fingertip forces during precision grasping and lifting, when applied over PMd. These findings support the role of PMd in human motor control and forces generation required to hold small objects stable in our hands.
AB  - Uvod/Cilj. Adaptivna kontrola i sinhronizacija sila prstiju šake tokom preciznog hvata pri manipulisanju malim predmetima jednom rukom predstavlja ilustrativni primer visoko frakcionisanih pokreta koji predstavljaju temelj motorne kontrole preciznih pokreta. Pretpostavlja se da ovim procesom upravlja nekoliko motornih oblasti frontalnog režnja, i to prvenstveno primarni motorni (M-1) i dorzalni premotorni korteks (PMd). Cilj istraživanja bio je ispitivanje uloge PMd-a tokom vršenja pokreta koji zahtevaju finu koordinaciju sila prstiju šake. U istraživanju smo primenili ponavljanu magnetnu stimulaciju pražnjenjima u teta frekvenciji, kako bi ometali neuralno procesiranje u toj oblasti moždane kore. Metode. Primenom jednostrano slepe studije, uz nasumičnu raspodelu i ukršteni dizajn, 10 zdravih ispitanika (29 ± 3,9 godina) bilo je izloženo pojedinačnim sesijama kontinuirane magnetne stimulacije (cTBS600), ili intermitentne ponavljane magnetne stimulacije (iTBS600), pražnjenjima u teta frekvenciji kao i prividnoj stimulaciji iznad PMd regiona dominantne hemisfere, odvojenih međusobno, najkraće nedelju dana. Precizanost hvata šake i podizanja procenjivani su uređajem koji je registrovao silu stiska (G) i silu podizanja (L) prilikom izvođenja tri zadatka (zadatak sa zadatim profilom L, zadatak sa oscilatornim variranjem nivoa L i zadatak sa podizanjem), koji su izvođeni sa obe ruke odvojeno, i to pre i nakon svake intervencije. Rezultati. Nakon primene iTBS protokola zabeleženo je poboljšanje izvođenja iskazano konstantnom greškom (CE) u zadatku sa oscilatornim variranjem nivoa L, kada je izvođen dominantnom rukom (DH), p = 0.009. Suprotno tome, primena cTBS protokola dovela je do smanjenja promenjive greške (VE) za nedominantnu ruku (NH), p = 0.005. Sa aspekta koordinacije sila utvrđeno je da je iTBS protokol doveo do pogoršanja rezultata praćenih pokazatelja za nedominantnu ruku (G/L odnos, p = 0.017; korelacija G i L, p = 0.047; prirast sile p = 0.047). Zaključak. Rezultati našeg istraživanja ukazuju na mogućnost modulacije sila prstiju šake tokom preciznog hvata i podizanja, ukoliko se TBS primeni iznad PMd-a. Dobijeni nalazi podržavaju ulogu PMd u motornoj kontroli i generisanju sila neophodnih za stabilno držanje malih predmeta kod ljudi.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Complex modulation of fingertip forces during precision grasp and lift after theta burst stimulation over the dorsal premotor cortex
T1  - Kompleksna modulacija sila tokom preciznog hvata šake primenom ponavljane transkranijalne magnetne stimulacije pražnjenjima u teta frekvenciji iznad dorzalnog premotornog korteksa
EP  - 535
IS  - 6
SP  - 526
VL  - 74
DO  - 10.2298/VSP151120249D
ER  - 

@article{
author = "Drljačić, Dragana and Pajić, Sanja and Nedeljković, Aleksandar and Milanović, Slađan and Ilić, Tihomir V.",
year = "2017",
abstract = "Background/Aim. Adaptive control and fingertip force synchronization of precise grasp stability during unimanual manipulation of small objects represents an illustrative example of highly fractionated movements that are foundation of fine motor control. It is assumed that this process is controlled by several motor areas of the frontal lobe, particularly applicable to the primary motor (M-1) and dorsal premotor cortex (PMd). Aiming to examine the role of PMd during fine coordination of fingertip forces we applied theta burst repetitive magnetic stimulation (TBS) to disrupt neural processing in that cortical area. Methods. Using a single-blind, randomized, crossover design, 10 healthy subjects (29 ± 3.9 years) received single sessions of continuous TBS (cTBS600), intermittent TBS (iTBS600), or sham stimulation, separate from one another at least one week, over the PMd region of dominant hemisphere. Precision grasp and lift were assessed by instrumented device, recording grip (G) and load (L) forces, during three manipulation tasks (ramp-and-hold, oscillation force producing and simple lifting tasks), with each hand separately, before and after interventions. Results. We observed the improvement of task performance related to constant error (CE) in oscillation task with the dominant hand (DH) after the iTBS (p = 0.009). On the contrary, the cTBS reduced variable error (VE) for non-dominant hand (NH), p = 0.005. Considering force coordination we found that iTBS worsened variables for NH (G/L ratio, p = 0.017; cross-correlation of the G and L, p = 0.047; Gain, p = 0.047). Conclusion. These results demonstrate the ability of TBS to modulate fingertip forces during precision grasping and lifting, when applied over PMd. These findings support the role of PMd in human motor control and forces generation required to hold small objects stable in our hands., Uvod/Cilj. Adaptivna kontrola i sinhronizacija sila prstiju šake tokom preciznog hvata pri manipulisanju malim predmetima jednom rukom predstavlja ilustrativni primer visoko frakcionisanih pokreta koji predstavljaju temelj motorne kontrole preciznih pokreta. Pretpostavlja se da ovim procesom upravlja nekoliko motornih oblasti frontalnog režnja, i to prvenstveno primarni motorni (M-1) i dorzalni premotorni korteks (PMd). Cilj istraživanja bio je ispitivanje uloge PMd-a tokom vršenja pokreta koji zahtevaju finu koordinaciju sila prstiju šake. U istraživanju smo primenili ponavljanu magnetnu stimulaciju pražnjenjima u teta frekvenciji, kako bi ometali neuralno procesiranje u toj oblasti moždane kore. Metode. Primenom jednostrano slepe studije, uz nasumičnu raspodelu i ukršteni dizajn, 10 zdravih ispitanika (29 ± 3,9 godina) bilo je izloženo pojedinačnim sesijama kontinuirane magnetne stimulacije (cTBS600), ili intermitentne ponavljane magnetne stimulacije (iTBS600), pražnjenjima u teta frekvenciji kao i prividnoj stimulaciji iznad PMd regiona dominantne hemisfere, odvojenih međusobno, najkraće nedelju dana. Precizanost hvata šake i podizanja procenjivani su uređajem koji je registrovao silu stiska (G) i silu podizanja (L) prilikom izvođenja tri zadatka (zadatak sa zadatim profilom L, zadatak sa oscilatornim variranjem nivoa L i zadatak sa podizanjem), koji su izvođeni sa obe ruke odvojeno, i to pre i nakon svake intervencije. Rezultati. Nakon primene iTBS protokola zabeleženo je poboljšanje izvođenja iskazano konstantnom greškom (CE) u zadatku sa oscilatornim variranjem nivoa L, kada je izvođen dominantnom rukom (DH), p = 0.009. Suprotno tome, primena cTBS protokola dovela je do smanjenja promenjive greške (VE) za nedominantnu ruku (NH), p = 0.005. Sa aspekta koordinacije sila utvrđeno je da je iTBS protokol doveo do pogoršanja rezultata praćenih pokazatelja za nedominantnu ruku (G/L odnos, p = 0.017; korelacija G i L, p = 0.047; prirast sile p = 0.047). Zaključak. Rezultati našeg istraživanja ukazuju na mogućnost modulacije sila prstiju šake tokom preciznog hvata i podizanja, ukoliko se TBS primeni iznad PMd-a. Dobijeni nalazi podržavaju ulogu PMd u motornoj kontroli i generisanju sila neophodnih za stabilno držanje malih predmeta kod ljudi.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Complex modulation of fingertip forces during precision grasp and lift after theta burst stimulation over the dorsal premotor cortex, Kompleksna modulacija sila tokom preciznog hvata šake primenom ponavljane transkranijalne magnetne stimulacije pražnjenjima u teta frekvenciji iznad dorzalnog premotornog korteksa",
pages = "535-526",
number = "6",
volume = "74",
doi = "10.2298/VSP151120249D"
}

Drljačić, D., Pajić, S., Nedeljković, A., Milanović, S.,& Ilić, T. V.. (2017). Complex modulation of fingertip forces during precision grasp and lift after theta burst stimulation over the dorsal premotor cortex. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 74(6), 526-535.
https://doi.org/10.2298/VSP151120249D

Drljačić D, Pajić S, Nedeljković A, Milanović S, Ilić TV. Complex modulation of fingertip forces during precision grasp and lift after theta burst stimulation over the dorsal premotor cortex. in Vojnosanitetski pregled. 2017;74(6):526-535.
doi:10.2298/VSP151120249D .

Drljačić, Dragana, Pajić, Sanja, Nedeljković, Aleksandar, Milanović, Slađan, Ilić, Tihomir V., "Complex modulation of fingertip forces during precision grasp and lift after theta burst stimulation over the dorsal premotor cortex" in Vojnosanitetski pregled, 74, no. 6 (2017):526-535,
https://doi.org/10.2298/VSP151120249D . .

TY  - JOUR
AU  - Grujić-Milanović, Jelica
AU  - Miloradović, Zoran
AU  - Jovović, Đurđica
AU  - Jacević, Vesna
AU  - Milosavljević, Ivica
AU  - Milanović, Slađan
AU  - Mihailović-Stanojević, Nevena
PY  - 2017
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/820
AB  - Resveratrol the polyphenolic antioxidant molecule has been proposed as an effective agent in the prevention of several pathological conditions, thus this study was aimed to evaluate its chronic effects on functional and structural remodeling of the aorta in spontaneously (SHR) and malignantly hypertensive rats (MHR). Resveratrol significantly decreased arterial pressure and improved regional hemodynamic parameters, bioavailability of nitric oxide, ameliorated morphological changes in the tunica media and smooth muscle of the aorta, preserved endothelium, reduced inflammation and apoptosis in both SHR and MHR, but excrete more beneficial effects on SHR. Resveratrol suppressed lipid peroxidation, significantly improved oxidative status and reduced levels of lipids. These results suggest the cardiovascular benefits of resveratrol dietary enrichment in both experimental models of hypertension.
PB  - Elsevier Science Bv, Amsterdam
T2  - Journal of Functional Foods
T1  - The red wine polyphenol, resveratrol improves hemodynamics, oxidative defence and aortal structure in essential and malignant hypertension
EP  - 276
SP  - 266
VL  - 34
DO  - 10.1016/j.jff.2017.04.035
ER  - 

@article{
author = "Grujić-Milanović, Jelica and Miloradović, Zoran and Jovović, Đurđica and Jacević, Vesna and Milosavljević, Ivica and Milanović, Slađan and Mihailović-Stanojević, Nevena",
year = "2017",
abstract = "Resveratrol the polyphenolic antioxidant molecule has been proposed as an effective agent in the prevention of several pathological conditions, thus this study was aimed to evaluate its chronic effects on functional and structural remodeling of the aorta in spontaneously (SHR) and malignantly hypertensive rats (MHR). Resveratrol significantly decreased arterial pressure and improved regional hemodynamic parameters, bioavailability of nitric oxide, ameliorated morphological changes in the tunica media and smooth muscle of the aorta, preserved endothelium, reduced inflammation and apoptosis in both SHR and MHR, but excrete more beneficial effects on SHR. Resveratrol suppressed lipid peroxidation, significantly improved oxidative status and reduced levels of lipids. These results suggest the cardiovascular benefits of resveratrol dietary enrichment in both experimental models of hypertension.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Journal of Functional Foods",
title = "The red wine polyphenol, resveratrol improves hemodynamics, oxidative defence and aortal structure in essential and malignant hypertension",
pages = "276-266",
volume = "34",
doi = "10.1016/j.jff.2017.04.035"
}

Grujić-Milanović, J., Miloradović, Z., Jovović, Đ., Jacević, V., Milosavljević, I., Milanović, S.,& Mihailović-Stanojević, N.. (2017). The red wine polyphenol, resveratrol improves hemodynamics, oxidative defence and aortal structure in essential and malignant hypertension. in Journal of Functional Foods
Elsevier Science Bv, Amsterdam., 34, 266-276.
https://doi.org/10.1016/j.jff.2017.04.035

Grujić-Milanović J, Miloradović Z, Jovović Đ, Jacević V, Milosavljević I, Milanović S, Mihailović-Stanojević N. The red wine polyphenol, resveratrol improves hemodynamics, oxidative defence and aortal structure in essential and malignant hypertension. in Journal of Functional Foods. 2017;34:266-276.
doi:10.1016/j.jff.2017.04.035 .

Grujić-Milanović, Jelica, Miloradović, Zoran, Jovović, Đurđica, Jacević, Vesna, Milosavljević, Ivica, Milanović, Slađan, Mihailović-Stanojević, Nevena, "The red wine polyphenol, resveratrol improves hemodynamics, oxidative defence and aortal structure in essential and malignant hypertension" in Journal of Functional Foods, 34 (2017):266-276,
https://doi.org/10.1016/j.jff.2017.04.035 . .

TY  - JOUR
AU  - Mancić, Bojana
AU  - Stevanović, Ivana
AU  - Ilić, Tihomir V.
AU  - Đurić, Ana
AU  - Stojanović, Ivana
AU  - Milanović, Slađan
AU  - Ninković, Milica
PY  - 2016
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/687
AB  - Repetitive transcranial magnetic stimulation (rTMS) induces changes in expression of proteins engaged in activity of excitatory and inhibitory systems as well as redox homeostasis. Our aim was to investigate the effect of single (SS) and repeated session (RS) of intermittentand continuous theta-burst stimulation (iTBS; cTBS) on the expression of vesicular and plasmatic glutamate transporters 1 (vGluT1 and GLT-1), glial fibrillary acidic protein (GFAP) and influence on oxidative status in rats cerebellar tissue and plasma. Redox state parameters in cerebellar tissue and plasma were assessed 24 h after single and 48 h after the last TBS session. Molecular changes were examined by immunofluorescence. Stimulation significantly increased thiol groups (SH) in tissue of SS iTBS group, and decreased in iTBS RS. Activity of glucose-6-phosphate-dehydrogenase (G6PD) was increased markedly in cTBS RS. Immunoreactivity of vGluT1 in cTBS RS decreased, while GLT-1 increased in cTBS SS and cTBS RS, compared to control. Present study gives insight in molecular and biochemical mechanisms by which iTBS and cTBS exerts its effects on rats cerebellar cortex.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Neurochemistry International
T1  - Transcranial theta-burst stimulation alters GLT-1 and vGluT1 expression in rat cerebellar cortex
EP  - 127
SP  - 120
VL  - 100
DO  - 10.1016/j.neuint.2016.09.009
ER  - 

@article{
author = "Mancić, Bojana and Stevanović, Ivana and Ilić, Tihomir V. and Đurić, Ana and Stojanović, Ivana and Milanović, Slađan and Ninković, Milica",
year = "2016",
abstract = "Repetitive transcranial magnetic stimulation (rTMS) induces changes in expression of proteins engaged in activity of excitatory and inhibitory systems as well as redox homeostasis. Our aim was to investigate the effect of single (SS) and repeated session (RS) of intermittentand continuous theta-burst stimulation (iTBS; cTBS) on the expression of vesicular and plasmatic glutamate transporters 1 (vGluT1 and GLT-1), glial fibrillary acidic protein (GFAP) and influence on oxidative status in rats cerebellar tissue and plasma. Redox state parameters in cerebellar tissue and plasma were assessed 24 h after single and 48 h after the last TBS session. Molecular changes were examined by immunofluorescence. Stimulation significantly increased thiol groups (SH) in tissue of SS iTBS group, and decreased in iTBS RS. Activity of glucose-6-phosphate-dehydrogenase (G6PD) was increased markedly in cTBS RS. Immunoreactivity of vGluT1 in cTBS RS decreased, while GLT-1 increased in cTBS SS and cTBS RS, compared to control. Present study gives insight in molecular and biochemical mechanisms by which iTBS and cTBS exerts its effects on rats cerebellar cortex.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Neurochemistry International",
title = "Transcranial theta-burst stimulation alters GLT-1 and vGluT1 expression in rat cerebellar cortex",
pages = "127-120",
volume = "100",
doi = "10.1016/j.neuint.2016.09.009"
}

Mancić, B., Stevanović, I., Ilić, T. V., Đurić, A., Stojanović, I., Milanović, S.,& Ninković, M.. (2016). Transcranial theta-burst stimulation alters GLT-1 and vGluT1 expression in rat cerebellar cortex. in Neurochemistry International
Pergamon-Elsevier Science Ltd, Oxford., 100, 120-127.
https://doi.org/10.1016/j.neuint.2016.09.009

Mancić B, Stevanović I, Ilić TV, Đurić A, Stojanović I, Milanović S, Ninković M. Transcranial theta-burst stimulation alters GLT-1 and vGluT1 expression in rat cerebellar cortex. in Neurochemistry International. 2016;100:120-127.
doi:10.1016/j.neuint.2016.09.009 .

Mancić, Bojana, Stevanović, Ivana, Ilić, Tihomir V., Đurić, Ana, Stojanović, Ivana, Milanović, Slađan, Ninković, Milica, "Transcranial theta-burst stimulation alters GLT-1 and vGluT1 expression in rat cerebellar cortex" in Neurochemistry International, 100 (2016):120-127,
https://doi.org/10.1016/j.neuint.2016.09.009 . .

TY  - JOUR
AU  - Ilić, Nela V.
AU  - Dubljanin-Raspopović, Emilija
AU  - Nedeljković, Una
AU  - Tomanovic-Vujadinović, Sanja
AU  - Milanović, Slađan
AU  - Petronic-Marković, Ivana
AU  - Ilić, Tihomir V.
PY  - 2016
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/711
AB  - Background: A growing body of evidence supports the effectiveness of using transcranial direct current stimulation (tDCS) in patients with chronic hand motor impairment resulting from stroke. Objective: In this study, we investigate and compare the combined effects of anodal tDCS and occupational therapy (OT) to sham stimulation with OT (control) on fine motor skill deficits of chronic stroke patients. Methods: A total of 26 stroke patients (at  gt = 9 months) were randomly assigned to an active treatment or a control group in a double-blinded, sham-controlled, parallel design study. Each group received OT for 45 min/day (10 sessions for 2 weeks). Treatment was preceded by either 20 minutes of 2mA anodal tDCS over ipsilesional M1 or sham tDCS. A modified Jebsen-Taylor Hand Function Test (mJTHFT) was administered as primary outcome measure, and handgrip dynamometer and upper limb Fugl-Meyer (ULFM) assessments were performed as secondary outcomes. The assessment was done at baseline (T0), after the interventions on day 1(T1), day 10 (T2) and day 40 (T3). Results: We observed a statistically significant effect in the tDCS group when the results were compared to the sham group. The mJTHFT times were significantly shorter immediately after treatment and at day 40. The intervention had no effect on handgrip strength or ULFM score. Conclusion: Fine motor skill deficits in chronic stroke survivors can be improved when intensive OT is primed with anodal tDCS over the ipsilesional hemisphere.
PB  - Ios Press, Amsterdam
T2  - Restorative Neurology & Neuroscience
T1  - Effects of anodal tDCS and occupational therapy on fine motor skill deficits in patients with chronic stroke
EP  - 945
IS  - 6
SP  - 935
VL  - 34
DO  - 10.3233/RNN-160668
ER  - 

@article{
author = "Ilić, Nela V. and Dubljanin-Raspopović, Emilija and Nedeljković, Una and Tomanovic-Vujadinović, Sanja and Milanović, Slađan and Petronic-Marković, Ivana and Ilić, Tihomir V.",
year = "2016",
abstract = "Background: A growing body of evidence supports the effectiveness of using transcranial direct current stimulation (tDCS) in patients with chronic hand motor impairment resulting from stroke. Objective: In this study, we investigate and compare the combined effects of anodal tDCS and occupational therapy (OT) to sham stimulation with OT (control) on fine motor skill deficits of chronic stroke patients. Methods: A total of 26 stroke patients (at  gt = 9 months) were randomly assigned to an active treatment or a control group in a double-blinded, sham-controlled, parallel design study. Each group received OT for 45 min/day (10 sessions for 2 weeks). Treatment was preceded by either 20 minutes of 2mA anodal tDCS over ipsilesional M1 or sham tDCS. A modified Jebsen-Taylor Hand Function Test (mJTHFT) was administered as primary outcome measure, and handgrip dynamometer and upper limb Fugl-Meyer (ULFM) assessments were performed as secondary outcomes. The assessment was done at baseline (T0), after the interventions on day 1(T1), day 10 (T2) and day 40 (T3). Results: We observed a statistically significant effect in the tDCS group when the results were compared to the sham group. The mJTHFT times were significantly shorter immediately after treatment and at day 40. The intervention had no effect on handgrip strength or ULFM score. Conclusion: Fine motor skill deficits in chronic stroke survivors can be improved when intensive OT is primed with anodal tDCS over the ipsilesional hemisphere.",
publisher = "Ios Press, Amsterdam",
journal = "Restorative Neurology & Neuroscience",
title = "Effects of anodal tDCS and occupational therapy on fine motor skill deficits in patients with chronic stroke",
pages = "945-935",
number = "6",
volume = "34",
doi = "10.3233/RNN-160668"
}

Ilić, N. V., Dubljanin-Raspopović, E., Nedeljković, U., Tomanovic-Vujadinović, S., Milanović, S., Petronic-Marković, I.,& Ilić, T. V.. (2016). Effects of anodal tDCS and occupational therapy on fine motor skill deficits in patients with chronic stroke. in Restorative Neurology & Neuroscience
Ios Press, Amsterdam., 34(6), 935-945.
https://doi.org/10.3233/RNN-160668

Ilić NV, Dubljanin-Raspopović E, Nedeljković U, Tomanovic-Vujadinović S, Milanović S, Petronic-Marković I, Ilić TV. Effects of anodal tDCS and occupational therapy on fine motor skill deficits in patients with chronic stroke. in Restorative Neurology & Neuroscience. 2016;34(6):935-945.
doi:10.3233/RNN-160668 .

Ilić, Nela V., Dubljanin-Raspopović, Emilija, Nedeljković, Una, Tomanovic-Vujadinović, Sanja, Milanović, Slađan, Petronic-Marković, Ivana, Ilić, Tihomir V., "Effects of anodal tDCS and occupational therapy on fine motor skill deficits in patients with chronic stroke" in Restorative Neurology & Neuroscience, 34, no. 6 (2016):935-945,
https://doi.org/10.3233/RNN-160668 . .

TY  - JOUR
AU  - Vasiljević-Pokrajcić, Zorana
AU  - Mickovski, Nataša
AU  - Davidović, Goran
AU  - Asanin, Milika
AU  - Stefanović, Branislav
AU  - Krljanac, Gordana
AU  - Radosavljević-Radovanović, Mina
AU  - Radovanović, Nebojša
AU  - Lasica, Ratko
AU  - Milanović, Slađan
AU  - Bjekić, Jovana
AU  - Majstorovic-Stakić, Marta
AU  - Trifunović, Danijela
AU  - Karadzić, Ana
AU  - Rajić, Dubravka
AU  - Milošević, Aleksandra
AU  - Zdravković, Marija
AU  - Sarić, Jelena
AU  - Bugiardini, Raffaele
PY  - 2016
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/743
AB  - Background: There is conflicting information about sex differences in presentation, treatment, and outcome after acute coronary syndromes (ACS) in the era of reperfusion therapy and percutaneous coronary intervention. The aim of this study was to examine presentation, acute therapy, and outcomes of men and women with ACS with special emphasis on their relationship with younger age ( lt = 65 years). Methods: From January 2010 to June 2015, we enrolled 5140 patients from 3 primary PCI capable hospitals. Patients were registered according to the International Survey of Acute Coronary Syndrome in Transitional Countries (ISACS-TC) registry protocol (ClinicalTrials.gov: NCT01218776). The primary outcome was the incidence of in-hospital mortality. Results: The study population was constituted by 2876 patients younger than 65 years and 2294 patients older. Women were older than men in both the young (56.2 +/- 6.6 vs. 54.1 +/- 7.4) and old (74.9 +/- 6.4 vs. 73.6 +/- 6.0) age groups. There were 3421 (66.2%) patients with ST elevation ACS (STE-ACS) and 1719 (33.8%) patients without ST elevation ACS (NSTE-ACS). In STE-ACS, the percentage of patients who failed to receive reperfusion was higher in women than in men either in the young (21.7% vs. 15.8%) than in the elderly (35.2% vs. 29.6%). There was a significant higher mortality in women in the younger age group (age-adjusted OR 1.52, 95% CI: 1.01-2.29), but there was no sex difference in the older group (age-adjusted OR 1.10, 95% CI: 0.87-1.41). Significantly sex differences in mortality were not seen in NSTE-ACS patients. Conclusions: In-hospital mortality from ACS is not different between older men and women. A higher short-term mortality can be seen only in women with STEMI and age of 65 or less.
PB  - Elsevier Ireland Ltd, Clare
T2  - International Journal of Cardiology
T1  - Sex and age differences and outcomes in acute coronary syndromes
EP  - S31
SP  - S27
VL  - 217
DO  - 10.1016/j.ijcard.2016.06.217
ER  - 

@article{
author = "Vasiljević-Pokrajcić, Zorana and Mickovski, Nataša and Davidović, Goran and Asanin, Milika and Stefanović, Branislav and Krljanac, Gordana and Radosavljević-Radovanović, Mina and Radovanović, Nebojša and Lasica, Ratko and Milanović, Slađan and Bjekić, Jovana and Majstorovic-Stakić, Marta and Trifunović, Danijela and Karadzić, Ana and Rajić, Dubravka and Milošević, Aleksandra and Zdravković, Marija and Sarić, Jelena and Bugiardini, Raffaele",
year = "2016",
abstract = "Background: There is conflicting information about sex differences in presentation, treatment, and outcome after acute coronary syndromes (ACS) in the era of reperfusion therapy and percutaneous coronary intervention. The aim of this study was to examine presentation, acute therapy, and outcomes of men and women with ACS with special emphasis on their relationship with younger age ( lt = 65 years). Methods: From January 2010 to June 2015, we enrolled 5140 patients from 3 primary PCI capable hospitals. Patients were registered according to the International Survey of Acute Coronary Syndrome in Transitional Countries (ISACS-TC) registry protocol (ClinicalTrials.gov: NCT01218776). The primary outcome was the incidence of in-hospital mortality. Results: The study population was constituted by 2876 patients younger than 65 years and 2294 patients older. Women were older than men in both the young (56.2 +/- 6.6 vs. 54.1 +/- 7.4) and old (74.9 +/- 6.4 vs. 73.6 +/- 6.0) age groups. There were 3421 (66.2%) patients with ST elevation ACS (STE-ACS) and 1719 (33.8%) patients without ST elevation ACS (NSTE-ACS). In STE-ACS, the percentage of patients who failed to receive reperfusion was higher in women than in men either in the young (21.7% vs. 15.8%) than in the elderly (35.2% vs. 29.6%). There was a significant higher mortality in women in the younger age group (age-adjusted OR 1.52, 95% CI: 1.01-2.29), but there was no sex difference in the older group (age-adjusted OR 1.10, 95% CI: 0.87-1.41). Significantly sex differences in mortality were not seen in NSTE-ACS patients. Conclusions: In-hospital mortality from ACS is not different between older men and women. A higher short-term mortality can be seen only in women with STEMI and age of 65 or less.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "International Journal of Cardiology",
title = "Sex and age differences and outcomes in acute coronary syndromes",
pages = "S31-S27",
volume = "217",
doi = "10.1016/j.ijcard.2016.06.217"
}

Vasiljević-Pokrajcić, Z., Mickovski, N., Davidović, G., Asanin, M., Stefanović, B., Krljanac, G., Radosavljević-Radovanović, M., Radovanović, N., Lasica, R., Milanović, S., Bjekić, J., Majstorovic-Stakić, M., Trifunović, D., Karadzić, A., Rajić, D., Milošević, A., Zdravković, M., Sarić, J.,& Bugiardini, R.. (2016). Sex and age differences and outcomes in acute coronary syndromes. in International Journal of Cardiology
Elsevier Ireland Ltd, Clare., 217, S27-S31.
https://doi.org/10.1016/j.ijcard.2016.06.217

Vasiljević-Pokrajcić Z, Mickovski N, Davidović G, Asanin M, Stefanović B, Krljanac G, Radosavljević-Radovanović M, Radovanović N, Lasica R, Milanović S, Bjekić J, Majstorovic-Stakić M, Trifunović D, Karadzić A, Rajić D, Milošević A, Zdravković M, Sarić J, Bugiardini R. Sex and age differences and outcomes in acute coronary syndromes. in International Journal of Cardiology. 2016;217:S27-S31.
doi:10.1016/j.ijcard.2016.06.217 .

Vasiljević-Pokrajcić, Zorana, Mickovski, Nataša, Davidović, Goran, Asanin, Milika, Stefanović, Branislav, Krljanac, Gordana, Radosavljević-Radovanović, Mina, Radovanović, Nebojša, Lasica, Ratko, Milanović, Slađan, Bjekić, Jovana, Majstorovic-Stakić, Marta, Trifunović, Danijela, Karadzić, Ana, Rajić, Dubravka, Milošević, Aleksandra, Zdravković, Marija, Sarić, Jelena, Bugiardini, Raffaele, "Sex and age differences and outcomes in acute coronary syndromes" in International Journal of Cardiology, 217 (2016):S27-S31,
https://doi.org/10.1016/j.ijcard.2016.06.217 . .