Effects of anodal tDCS and occupational therapy on fine motor skill deficits in patients with chronic stroke
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Аутори
Ilić, Nela V.Dubljanin-Raspopović, Emilija
Nedeljković, Una
Tomanovic-Vujadinović, Sanja
Milanović, Slađan
Petronic-Marković, Ivana
Ilić, Tihomir V.
Чланак у часопису (Објављена верзија)
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Background: A growing body of evidence supports the effectiveness of using transcranial direct current stimulation (tDCS) in patients with chronic hand motor impairment resulting from stroke. Objective: In this study, we investigate and compare the combined effects of anodal tDCS and occupational therapy (OT) to sham stimulation with OT (control) on fine motor skill deficits of chronic stroke patients. Methods: A total of 26 stroke patients (at gt = 9 months) were randomly assigned to an active treatment or a control group in a double-blinded, sham-controlled, parallel design study. Each group received OT for 45 min/day (10 sessions for 2 weeks). Treatment was preceded by either 20 minutes of 2mA anodal tDCS over ipsilesional M1 or sham tDCS. A modified Jebsen-Taylor Hand Function Test (mJTHFT) was administered as primary outcome measure, and handgrip dynamometer and upper limb Fugl-Meyer (ULFM) assessments were performed as secondary outcomes. The assessment was done at baseline (T0)..., after the interventions on day 1(T1), day 10 (T2) and day 40 (T3). Results: We observed a statistically significant effect in the tDCS group when the results were compared to the sham group. The mJTHFT times were significantly shorter immediately after treatment and at day 40. The intervention had no effect on handgrip strength or ULFM score. Conclusion: Fine motor skill deficits in chronic stroke survivors can be improved when intensive OT is primed with anodal tDCS over the ipsilesional hemisphere.
Кључне речи:
Stroke recovery / rehabilitation / non-invasive brain stimulation / transcranial direct current stimulation / occupational therapyИзвор:
Restorative Neurology & Neuroscience, 2016, 34, 6, 935-945Издавач:
- Ios Press, Amsterdam
Финансирање / пројекти:
- Ministry of Defence of the Republic of Serbia [MFVMA/07/16-18]
- Ћелијска и молекулска основа неуроинфламације: потенцијала циљна места за транслациону медицину и терапију (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41014)
- Неинвазивна модулација кортикалне ексцитабилности и пластицитета - Развој метода неинвазивне неуромодулације централног нервног система у испитивања физиолошких механизама, дијагностици и терапији (RS-MESTD-Basic Research (BR or ON)-175012)
DOI: 10.3233/RNN-160668
ISSN: 0922-6028
PubMed: 27689551
WoS: 000389243100006
Scopus: 2-s2.0-84999652756
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Ilić, Nela V. AU - Dubljanin-Raspopović, Emilija AU - Nedeljković, Una AU - Tomanovic-Vujadinović, Sanja AU - Milanović, Slađan AU - Petronic-Marković, Ivana AU - Ilić, Tihomir V. PY - 2016 UR - http://rimi.imi.bg.ac.rs/handle/123456789/711 AB - Background: A growing body of evidence supports the effectiveness of using transcranial direct current stimulation (tDCS) in patients with chronic hand motor impairment resulting from stroke. Objective: In this study, we investigate and compare the combined effects of anodal tDCS and occupational therapy (OT) to sham stimulation with OT (control) on fine motor skill deficits of chronic stroke patients. Methods: A total of 26 stroke patients (at gt = 9 months) were randomly assigned to an active treatment or a control group in a double-blinded, sham-controlled, parallel design study. Each group received OT for 45 min/day (10 sessions for 2 weeks). Treatment was preceded by either 20 minutes of 2mA anodal tDCS over ipsilesional M1 or sham tDCS. A modified Jebsen-Taylor Hand Function Test (mJTHFT) was administered as primary outcome measure, and handgrip dynamometer and upper limb Fugl-Meyer (ULFM) assessments were performed as secondary outcomes. The assessment was done at baseline (T0), after the interventions on day 1(T1), day 10 (T2) and day 40 (T3). Results: We observed a statistically significant effect in the tDCS group when the results were compared to the sham group. The mJTHFT times were significantly shorter immediately after treatment and at day 40. The intervention had no effect on handgrip strength or ULFM score. Conclusion: Fine motor skill deficits in chronic stroke survivors can be improved when intensive OT is primed with anodal tDCS over the ipsilesional hemisphere. PB - Ios Press, Amsterdam T2 - Restorative Neurology & Neuroscience T1 - Effects of anodal tDCS and occupational therapy on fine motor skill deficits in patients with chronic stroke EP - 945 IS - 6 SP - 935 VL - 34 DO - 10.3233/RNN-160668 ER -
@article{ author = "Ilić, Nela V. and Dubljanin-Raspopović, Emilija and Nedeljković, Una and Tomanovic-Vujadinović, Sanja and Milanović, Slađan and Petronic-Marković, Ivana and Ilić, Tihomir V.", year = "2016", abstract = "Background: A growing body of evidence supports the effectiveness of using transcranial direct current stimulation (tDCS) in patients with chronic hand motor impairment resulting from stroke. Objective: In this study, we investigate and compare the combined effects of anodal tDCS and occupational therapy (OT) to sham stimulation with OT (control) on fine motor skill deficits of chronic stroke patients. Methods: A total of 26 stroke patients (at gt = 9 months) were randomly assigned to an active treatment or a control group in a double-blinded, sham-controlled, parallel design study. Each group received OT for 45 min/day (10 sessions for 2 weeks). Treatment was preceded by either 20 minutes of 2mA anodal tDCS over ipsilesional M1 or sham tDCS. A modified Jebsen-Taylor Hand Function Test (mJTHFT) was administered as primary outcome measure, and handgrip dynamometer and upper limb Fugl-Meyer (ULFM) assessments were performed as secondary outcomes. The assessment was done at baseline (T0), after the interventions on day 1(T1), day 10 (T2) and day 40 (T3). Results: We observed a statistically significant effect in the tDCS group when the results were compared to the sham group. The mJTHFT times were significantly shorter immediately after treatment and at day 40. The intervention had no effect on handgrip strength or ULFM score. Conclusion: Fine motor skill deficits in chronic stroke survivors can be improved when intensive OT is primed with anodal tDCS over the ipsilesional hemisphere.", publisher = "Ios Press, Amsterdam", journal = "Restorative Neurology & Neuroscience", title = "Effects of anodal tDCS and occupational therapy on fine motor skill deficits in patients with chronic stroke", pages = "945-935", number = "6", volume = "34", doi = "10.3233/RNN-160668" }
Ilić, N. V., Dubljanin-Raspopović, E., Nedeljković, U., Tomanovic-Vujadinović, S., Milanović, S., Petronic-Marković, I.,& Ilić, T. V.. (2016). Effects of anodal tDCS and occupational therapy on fine motor skill deficits in patients with chronic stroke. in Restorative Neurology & Neuroscience Ios Press, Amsterdam., 34(6), 935-945. https://doi.org/10.3233/RNN-160668
Ilić NV, Dubljanin-Raspopović E, Nedeljković U, Tomanovic-Vujadinović S, Milanović S, Petronic-Marković I, Ilić TV. Effects of anodal tDCS and occupational therapy on fine motor skill deficits in patients with chronic stroke. in Restorative Neurology & Neuroscience. 2016;34(6):935-945. doi:10.3233/RNN-160668 .
Ilić, Nela V., Dubljanin-Raspopović, Emilija, Nedeljković, Una, Tomanovic-Vujadinović, Sanja, Milanović, Slađan, Petronic-Marković, Ivana, Ilić, Tihomir V., "Effects of anodal tDCS and occupational therapy on fine motor skill deficits in patients with chronic stroke" in Restorative Neurology & Neuroscience, 34, no. 6 (2016):935-945, https://doi.org/10.3233/RNN-160668 . .