Resveratrol improved kidney function and structure in malignantly hypertensive rats by restoration of antioxidant capacity and nitric oxide bioavailability
Аутори
Grujić-Milanović, JelicaJaćević, Vesna
Miloradović, Zoran
Milanović, Slađan
Jovović, Đurđica
Ivanov, Milan
Karanović, Danijela
Vajić, Una Jovana
Mihailović-Stanojević, Nevena
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Objective Background: The main cause of death among patients with malignant hypertension is a kidney failure. The promising field in essential and malignant hypertension therapy could be centered on the amelioration of oxidative stress using antioxidant molecules like resveratrol. Resveratrol is a potent antioxidative agent naturally occurred in many plants that possess health-promoting properties. Methods: In the present study, we investigated the therapeutic potential of resveratrol, a polyphenol with anti-oxidative activity, in NG-L-Arginine Methyl Ester (L-NAME) treated spontaneously hypertensive rats (SHR) - malignantly hypertensive rats (MHR). Results: Resveratrol significantly improves oxidative damages by modulation of antioxidant enzymes and suppression of prooxidant factors in the kidney tissue of MHR. Enhanced antioxidant defense in the kidney improves renal function and ameliorates the morphological changes in this target organ. Besides, protective properties of resveratrol... are followed by the restoration of the nitrogen oxide (NO) pathway. 4) Conclusion: Antioxidant therapy with resveratrol could represent promising therapeutical approach in hypertension, especially malignant, against kidney damage.
Кључне речи:
Kidney / L-NAME / Nitrotyrosine / Oxidative stress / Resveratrol / Spontaneously and malignant hypertensionИзвор:
Biomedicine & Pharmacotherapy, 2022, 154, 113642-Издавач:
- Elsevier
Финансирање / пројекти:
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Grujić-Milanović, Jelica AU - Jaćević, Vesna AU - Miloradović, Zoran AU - Milanović, Slađan AU - Jovović, Đurđica AU - Ivanov, Milan AU - Karanović, Danijela AU - Vajić, Una Jovana AU - Mihailović-Stanojević, Nevena PY - 2022 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1263 AB - Objective Background: The main cause of death among patients with malignant hypertension is a kidney failure. The promising field in essential and malignant hypertension therapy could be centered on the amelioration of oxidative stress using antioxidant molecules like resveratrol. Resveratrol is a potent antioxidative agent naturally occurred in many plants that possess health-promoting properties. Methods: In the present study, we investigated the therapeutic potential of resveratrol, a polyphenol with anti-oxidative activity, in NG-L-Arginine Methyl Ester (L-NAME) treated spontaneously hypertensive rats (SHR) - malignantly hypertensive rats (MHR). Results: Resveratrol significantly improves oxidative damages by modulation of antioxidant enzymes and suppression of prooxidant factors in the kidney tissue of MHR. Enhanced antioxidant defense in the kidney improves renal function and ameliorates the morphological changes in this target organ. Besides, protective properties of resveratrol are followed by the restoration of the nitrogen oxide (NO) pathway. 4) Conclusion: Antioxidant therapy with resveratrol could represent promising therapeutical approach in hypertension, especially malignant, against kidney damage. T2 - Biomedicine & Pharmacotherapy T1 - Resveratrol improved kidney function and structure in malignantly hypertensive rats by restoration of antioxidant capacity and nitric oxide bioavailability SP - 113642 VL - 154 DO - 10.1016/j.biopha.2022.113642 ER -
@article{ author = "Grujić-Milanović, Jelica and Jaćević, Vesna and Miloradović, Zoran and Milanović, Slađan and Jovović, Đurđica and Ivanov, Milan and Karanović, Danijela and Vajić, Una Jovana and Mihailović-Stanojević, Nevena", year = "2022", abstract = "Objective Background: The main cause of death among patients with malignant hypertension is a kidney failure. The promising field in essential and malignant hypertension therapy could be centered on the amelioration of oxidative stress using antioxidant molecules like resveratrol. Resveratrol is a potent antioxidative agent naturally occurred in many plants that possess health-promoting properties. Methods: In the present study, we investigated the therapeutic potential of resveratrol, a polyphenol with anti-oxidative activity, in NG-L-Arginine Methyl Ester (L-NAME) treated spontaneously hypertensive rats (SHR) - malignantly hypertensive rats (MHR). Results: Resveratrol significantly improves oxidative damages by modulation of antioxidant enzymes and suppression of prooxidant factors in the kidney tissue of MHR. Enhanced antioxidant defense in the kidney improves renal function and ameliorates the morphological changes in this target organ. Besides, protective properties of resveratrol are followed by the restoration of the nitrogen oxide (NO) pathway. 4) Conclusion: Antioxidant therapy with resveratrol could represent promising therapeutical approach in hypertension, especially malignant, against kidney damage.", journal = "Biomedicine & Pharmacotherapy", title = "Resveratrol improved kidney function and structure in malignantly hypertensive rats by restoration of antioxidant capacity and nitric oxide bioavailability", pages = "113642", volume = "154", doi = "10.1016/j.biopha.2022.113642" }
Grujić-Milanović, J., Jaćević, V., Miloradović, Z., Milanović, S., Jovović, Đ., Ivanov, M., Karanović, D., Vajić, U. J.,& Mihailović-Stanojević, N.. (2022). Resveratrol improved kidney function and structure in malignantly hypertensive rats by restoration of antioxidant capacity and nitric oxide bioavailability. in Biomedicine & Pharmacotherapy, 154, 113642. https://doi.org/10.1016/j.biopha.2022.113642
Grujić-Milanović J, Jaćević V, Miloradović Z, Milanović S, Jovović Đ, Ivanov M, Karanović D, Vajić UJ, Mihailović-Stanojević N. Resveratrol improved kidney function and structure in malignantly hypertensive rats by restoration of antioxidant capacity and nitric oxide bioavailability. in Biomedicine & Pharmacotherapy. 2022;154:113642. doi:10.1016/j.biopha.2022.113642 .
Grujić-Milanović, Jelica, Jaćević, Vesna, Miloradović, Zoran, Milanović, Slađan, Jovović, Đurđica, Ivanov, Milan, Karanović, Danijela, Vajić, Una Jovana, Mihailović-Stanojević, Nevena, "Resveratrol improved kidney function and structure in malignantly hypertensive rats by restoration of antioxidant capacity and nitric oxide bioavailability" in Biomedicine & Pharmacotherapy, 154 (2022):113642, https://doi.org/10.1016/j.biopha.2022.113642 . .