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Proinflammatory Cytokine IL-6 and JAK-STAT Signaling Pathway in Myeloproliferative Neoplasms
(Hindawi Ltd, London, 2015)
The recent JAK1/2 inhibitor trial in myeloproliferative neoplasms (MPNs) showed that reducing inflammation can be more beneficial than targeting gene mutants. We evaluated the proinflammatory IL-6 cytokine and JAK-STAT ...
Glucocorticoid receptor mediates the expansion of splenic late erythroid progenitors during chronic psychological stress
(Polish Physiological Soc, Grzegorzecka, 2015)
Stress evokes an integrated neuroendocrine response perturbing the homeostasis of different physiological systems. In contrast to well established physiologica linteractions between neuroendocrine and immune systems during ...
Fatty Acids: Fatty Acids
(Encyclopedia of Food & Health, 2015)
Fatty acids (FAs) are long hydrocarbon chain molecules with a terminal carboxylate group, originating from the organism or food. Their nomenclature, structure, and properties depend on the length of hydrocarbon chain, ...
Gene expression profile of circulating CD34(+) cells and granulocytes in chronic myeloid leukemia
(Academic Press Inc Elsevier Science, San Diego, 2015)
Purpose: We compared the gene expression profile of peripheral blood CD34(+) cells and granulocytes in subjects with chronic myeloid leukemia (CML), with the accent on signaling pathways affected by BCR-ABL oncogene. ...
Investigation into novel thiophene- and furan-based 4-amino-7-chloroquinolines afforded antimalarials that cure mice
(Pergamon-Elsevier Science Ltd, Oxford, 2015)
We herein report the design and synthesis of a novel series of thiophene-and furan-based aminoquinoline derivatives which were found to be potent antimalarials and inhibitors of b-hematin polymerization. Tested compounds ...
Transforming Growth Factor-Beta and Oxidative Stress Interplay: Implications in Tumorigenesis and Cancer Progression
(Hindawi Ltd, London, 2015)
Transforming growth factor-beta (TGF-beta) and oxidative stress/ReactiveOxygen Species (ROS) both have pivotal roles in health and disease. In this review we are analyzing the interplay between TGF-beta and ROS in tumorigenesis ...
Predictability of lead-210 in surface air based on multivariate analysis
(Rad Assoc, `, 2015)
Dependence of the lead-210 activity concentration in surface air on meteorological variables and teleconnection indices is investigated using multivariate analysis, which gives the Boosted Decision Trees method as the most ...
Blood donors' positivity for transfusion-transmissible infections: the Serbian Military Medical Academy experience
(Simiti Servizi Srl, Milan, 2015)
Background. Members of armed forces worldwide are considered to be very susceptible to sexually transmitted infections, thus falling into a high-risk group of blood donors regarding transfusion-transmissible infections. ...