Transforming Growth Factor-Beta and Oxidative Stress Interplay: Implications in Tumorigenesis and Cancer Progression
Abstract
Transforming growth factor-beta (TGF-beta) and oxidative stress/ReactiveOxygen Species (ROS) both have pivotal roles in health and disease. In this review we are analyzing the interplay between TGF-beta and ROS in tumorigenesis and cancer progression. They have contradictory roles in cancer progression since both can have antitumor effects, through the induction of cell death, senescence and cell cycle arrest, and protumor effects by contributing to cancer cell spreading, proliferation, survival, and metastasis. TGF-beta can control ROS production directly or by downregulating antioxidative systems. Meanwhile, ROS can influence TGF-beta signaling and increase its expression as well as its activation from the latent complex. This way, both are building a strong interplay which can be taken as an advantage by cancer cells in order to increment their malignancy. In addition, both TGF-beta and ROS are able to induce cell senescence, which in one way protects damaged cells fromneoplastic tr...ansformation but alsomay collaborate in cancer progression. The mutual collaboration of TGF-beta and ROS in tumorigenesis is highly complex, and, due to their differential roles in tumor progression, careful consideration should be taken when thinking of combinatorial targeting in cancer therapies.
Source:
Oxidative Medicine & Cellular Longevity, 2015, 2015Publisher:
- Hindawi Ltd, London
Funding / projects:
DOI: 10.1155/2015/654594
ISSN: 1942-0900
PubMed: 26078812
WoS: 000356288800001
Scopus: 2-s2.0-84930960050
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Institution/Community
Institut za medicinska istraživanjaTY - JOUR AU - Krstić, Jelena AU - Trivanović, Drenka AU - Mojsilović, Slavko AU - Santibanez, Juan PY - 2015 UR - http://rimi.imi.bg.ac.rs/handle/123456789/681 AB - Transforming growth factor-beta (TGF-beta) and oxidative stress/ReactiveOxygen Species (ROS) both have pivotal roles in health and disease. In this review we are analyzing the interplay between TGF-beta and ROS in tumorigenesis and cancer progression. They have contradictory roles in cancer progression since both can have antitumor effects, through the induction of cell death, senescence and cell cycle arrest, and protumor effects by contributing to cancer cell spreading, proliferation, survival, and metastasis. TGF-beta can control ROS production directly or by downregulating antioxidative systems. Meanwhile, ROS can influence TGF-beta signaling and increase its expression as well as its activation from the latent complex. This way, both are building a strong interplay which can be taken as an advantage by cancer cells in order to increment their malignancy. In addition, both TGF-beta and ROS are able to induce cell senescence, which in one way protects damaged cells fromneoplastic transformation but alsomay collaborate in cancer progression. The mutual collaboration of TGF-beta and ROS in tumorigenesis is highly complex, and, due to their differential roles in tumor progression, careful consideration should be taken when thinking of combinatorial targeting in cancer therapies. PB - Hindawi Ltd, London T2 - Oxidative Medicine & Cellular Longevity T1 - Transforming Growth Factor-Beta and Oxidative Stress Interplay: Implications in Tumorigenesis and Cancer Progression VL - 2015 DO - 10.1155/2015/654594 ER -
@article{ author = "Krstić, Jelena and Trivanović, Drenka and Mojsilović, Slavko and Santibanez, Juan", year = "2015", abstract = "Transforming growth factor-beta (TGF-beta) and oxidative stress/ReactiveOxygen Species (ROS) both have pivotal roles in health and disease. In this review we are analyzing the interplay between TGF-beta and ROS in tumorigenesis and cancer progression. They have contradictory roles in cancer progression since both can have antitumor effects, through the induction of cell death, senescence and cell cycle arrest, and protumor effects by contributing to cancer cell spreading, proliferation, survival, and metastasis. TGF-beta can control ROS production directly or by downregulating antioxidative systems. Meanwhile, ROS can influence TGF-beta signaling and increase its expression as well as its activation from the latent complex. This way, both are building a strong interplay which can be taken as an advantage by cancer cells in order to increment their malignancy. In addition, both TGF-beta and ROS are able to induce cell senescence, which in one way protects damaged cells fromneoplastic transformation but alsomay collaborate in cancer progression. The mutual collaboration of TGF-beta and ROS in tumorigenesis is highly complex, and, due to their differential roles in tumor progression, careful consideration should be taken when thinking of combinatorial targeting in cancer therapies.", publisher = "Hindawi Ltd, London", journal = "Oxidative Medicine & Cellular Longevity", title = "Transforming Growth Factor-Beta and Oxidative Stress Interplay: Implications in Tumorigenesis and Cancer Progression", volume = "2015", doi = "10.1155/2015/654594" }
Krstić, J., Trivanović, D., Mojsilović, S.,& Santibanez, J.. (2015). Transforming Growth Factor-Beta and Oxidative Stress Interplay: Implications in Tumorigenesis and Cancer Progression. in Oxidative Medicine & Cellular Longevity Hindawi Ltd, London., 2015. https://doi.org/10.1155/2015/654594
Krstić J, Trivanović D, Mojsilović S, Santibanez J. Transforming Growth Factor-Beta and Oxidative Stress Interplay: Implications in Tumorigenesis and Cancer Progression. in Oxidative Medicine & Cellular Longevity. 2015;2015. doi:10.1155/2015/654594 .
Krstić, Jelena, Trivanović, Drenka, Mojsilović, Slavko, Santibanez, Juan, "Transforming Growth Factor-Beta and Oxidative Stress Interplay: Implications in Tumorigenesis and Cancer Progression" in Oxidative Medicine & Cellular Longevity, 2015 (2015), https://doi.org/10.1155/2015/654594 . .