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Transforming Growth Factor-Beta and Oxidative Stress Interplay: Implications in Tumorigenesis and Cancer Progression

Thumbnail
2015
678.pdf (3.187Mb)
Authors
Krstić, Jelena
Trivanović, Drenka
Mojsilović, Slavko
Santibanez, Juan
Article (Published version)
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Abstract
Transforming growth factor-beta (TGF-beta) and oxidative stress/ReactiveOxygen Species (ROS) both have pivotal roles in health and disease. In this review we are analyzing the interplay between TGF-beta and ROS in tumorigenesis and cancer progression. They have contradictory roles in cancer progression since both can have antitumor effects, through the induction of cell death, senescence and cell cycle arrest, and protumor effects by contributing to cancer cell spreading, proliferation, survival, and metastasis. TGF-beta can control ROS production directly or by downregulating antioxidative systems. Meanwhile, ROS can influence TGF-beta signaling and increase its expression as well as its activation from the latent complex. This way, both are building a strong interplay which can be taken as an advantage by cancer cells in order to increment their malignancy. In addition, both TGF-beta and ROS are able to induce cell senescence, which in one way protects damaged cells fromneoplastic tr...ansformation but alsomay collaborate in cancer progression. The mutual collaboration of TGF-beta and ROS in tumorigenesis is highly complex, and, due to their differential roles in tumor progression, careful consideration should be taken when thinking of combinatorial targeting in cancer therapies.

Source:
Oxidative Medicine & Cellular Longevity, 2015, 2015
Publisher:
  • Hindawi Ltd, London
Funding / projects:
  • Regenerative and modulatory potential of adult stem cells (RS-175062)

DOI: 10.1155/2015/654594

ISSN: 1942-0900

PubMed: 26078812

WoS: 000356288800001

Scopus: 2-s2.0-84930960050
[ Google Scholar ]
143
113
URI
http://rimi.imi.bg.ac.rs/handle/123456789/681
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
Institut za medicinska istraživanja
TY  - JOUR
AU  - Krstić, Jelena
AU  - Trivanović, Drenka
AU  - Mojsilović, Slavko
AU  - Santibanez, Juan
PY  - 2015
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/681
AB  - Transforming growth factor-beta (TGF-beta) and oxidative stress/ReactiveOxygen Species (ROS) both have pivotal roles in health and disease. In this review we are analyzing the interplay between TGF-beta and ROS in tumorigenesis and cancer progression. They have contradictory roles in cancer progression since both can have antitumor effects, through the induction of cell death, senescence and cell cycle arrest, and protumor effects by contributing to cancer cell spreading, proliferation, survival, and metastasis. TGF-beta can control ROS production directly or by downregulating antioxidative systems. Meanwhile, ROS can influence TGF-beta signaling and increase its expression as well as its activation from the latent complex. This way, both are building a strong interplay which can be taken as an advantage by cancer cells in order to increment their malignancy. In addition, both TGF-beta and ROS are able to induce cell senescence, which in one way protects damaged cells fromneoplastic transformation but alsomay collaborate in cancer progression. The mutual collaboration of TGF-beta and ROS in tumorigenesis is highly complex, and, due to their differential roles in tumor progression, careful consideration should be taken when thinking of combinatorial targeting in cancer therapies.
PB  - Hindawi Ltd, London
T2  - Oxidative Medicine & Cellular Longevity
T1  - Transforming Growth Factor-Beta and Oxidative Stress Interplay: Implications in Tumorigenesis and Cancer Progression
VL  - 2015
DO  - 10.1155/2015/654594
ER  - 
@article{
author = "Krstić, Jelena and Trivanović, Drenka and Mojsilović, Slavko and Santibanez, Juan",
year = "2015",
abstract = "Transforming growth factor-beta (TGF-beta) and oxidative stress/ReactiveOxygen Species (ROS) both have pivotal roles in health and disease. In this review we are analyzing the interplay between TGF-beta and ROS in tumorigenesis and cancer progression. They have contradictory roles in cancer progression since both can have antitumor effects, through the induction of cell death, senescence and cell cycle arrest, and protumor effects by contributing to cancer cell spreading, proliferation, survival, and metastasis. TGF-beta can control ROS production directly or by downregulating antioxidative systems. Meanwhile, ROS can influence TGF-beta signaling and increase its expression as well as its activation from the latent complex. This way, both are building a strong interplay which can be taken as an advantage by cancer cells in order to increment their malignancy. In addition, both TGF-beta and ROS are able to induce cell senescence, which in one way protects damaged cells fromneoplastic transformation but alsomay collaborate in cancer progression. The mutual collaboration of TGF-beta and ROS in tumorigenesis is highly complex, and, due to their differential roles in tumor progression, careful consideration should be taken when thinking of combinatorial targeting in cancer therapies.",
publisher = "Hindawi Ltd, London",
journal = "Oxidative Medicine & Cellular Longevity",
title = "Transforming Growth Factor-Beta and Oxidative Stress Interplay: Implications in Tumorigenesis and Cancer Progression",
volume = "2015",
doi = "10.1155/2015/654594"
}
Krstić, J., Trivanović, D., Mojsilović, S.,& Santibanez, J.. (2015). Transforming Growth Factor-Beta and Oxidative Stress Interplay: Implications in Tumorigenesis and Cancer Progression. in Oxidative Medicine & Cellular Longevity
Hindawi Ltd, London., 2015.
https://doi.org/10.1155/2015/654594
conv_3517
Krstić J, Trivanović D, Mojsilović S, Santibanez J. Transforming Growth Factor-Beta and Oxidative Stress Interplay: Implications in Tumorigenesis and Cancer Progression. in Oxidative Medicine & Cellular Longevity. 2015;2015.
doi:10.1155/2015/654594
conv_3517 .
Krstić, Jelena, Trivanović, Drenka, Mojsilović, Slavko, Santibanez, Juan, "Transforming Growth Factor-Beta and Oxidative Stress Interplay: Implications in Tumorigenesis and Cancer Progression" in Oxidative Medicine & Cellular Longevity, 2015 (2015),
https://doi.org/10.1155/2015/654594 .,
conv_3517 .

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