TY  - JOUR
AU  - Momčilović, Sanja
AU  - Bogdanović, Andrija
AU  - Milošević, Maja
AU  - Mojsilović, Slavko
AU  - Marković, Dragana
AU  - Kočović, Dušica M.
AU  - Vignjević-Petrinović, Sanja
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1329
AB  - Psychological stress is a significant contributor to various chronic diseases and affects multiple physiological processes including erythropoiesis. This study aimed to examine the tissue-specific contributions of macrophages and extracellular ATP, as a signal of disturbed tissue homeostasis, to erythropoiesis under conditions of repeated psychological stress. Adult male BALB/c mice were subjected to 2 h daily restraint stress for seven consecutive days. Clodronate-liposomes were used to deplete resident macrophages from the bone marrow and spleen two days prior to the first restraint procedure, as well as newly recruited macrophages, every third day for the duration of the experiment. Repeated stress induced a considerable increase in the number of erythroid progenitor cells as well as in the percentage of CD71+/Ter119+ and CD71−/Ter119+ cells in the bone marrow and spleen. Macrophage depletion completely abolished the stimulative effect of repeated stress on immature erythroid cells, and prevented stress-induced increases in ATP levels, P2X7 receptor (P2X7R) expression, and ectonucleotidase CD39 activity and expression in the bone marrow and spleen. The obtained results demonstrate the stimulative effects of repeated stress on erythroid cells, extracellular ATP levels, P2X7R expression, CD39 activity and expression within the bone marrow and spleen, as well as the essential role of macrophages in stress-induced changes.
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
T2  - International Journal of Molecular Sciences
T2  - International Journal of Molecular Sciences
T1  - Macrophages Provide Essential Support for Erythropoiesis, and Extracellular ATP Contributes to a Erythropoiesis-Supportive Microenvironment during Repeated Psychological Stress
IS  - 14
SP  - 11373
VL  - 24
DO  - 10.3390/ijms241411373
ER  - 

@article{
author = "Momčilović, Sanja and Bogdanović, Andrija and Milošević, Maja and Mojsilović, Slavko and Marković, Dragana and Kočović, Dušica M. and Vignjević-Petrinović, Sanja",
year = "2023",
abstract = "Psychological stress is a significant contributor to various chronic diseases and affects multiple physiological processes including erythropoiesis. This study aimed to examine the tissue-specific contributions of macrophages and extracellular ATP, as a signal of disturbed tissue homeostasis, to erythropoiesis under conditions of repeated psychological stress. Adult male BALB/c mice were subjected to 2 h daily restraint stress for seven consecutive days. Clodronate-liposomes were used to deplete resident macrophages from the bone marrow and spleen two days prior to the first restraint procedure, as well as newly recruited macrophages, every third day for the duration of the experiment. Repeated stress induced a considerable increase in the number of erythroid progenitor cells as well as in the percentage of CD71+/Ter119+ and CD71−/Ter119+ cells in the bone marrow and spleen. Macrophage depletion completely abolished the stimulative effect of repeated stress on immature erythroid cells, and prevented stress-induced increases in ATP levels, P2X7 receptor (P2X7R) expression, and ectonucleotidase CD39 activity and expression in the bone marrow and spleen. The obtained results demonstrate the stimulative effects of repeated stress on erythroid cells, extracellular ATP levels, P2X7R expression, CD39 activity and expression within the bone marrow and spleen, as well as the essential role of macrophages in stress-induced changes.",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "International Journal of Molecular Sciences, International Journal of Molecular Sciences",
title = "Macrophages Provide Essential Support for Erythropoiesis, and Extracellular ATP Contributes to a Erythropoiesis-Supportive Microenvironment during Repeated Psychological Stress",
number = "14",
pages = "11373",
volume = "24",
doi = "10.3390/ijms241411373"
}

Momčilović, S., Bogdanović, A., Milošević, M., Mojsilović, S., Marković, D., Kočović, D. M.,& Vignjević-Petrinović, S.. (2023). Macrophages Provide Essential Support for Erythropoiesis, and Extracellular ATP Contributes to a Erythropoiesis-Supportive Microenvironment during Repeated Psychological Stress. in International Journal of Molecular Sciences
Multidisciplinary Digital Publishing Institute (MDPI)., 24(14), 11373.
https://doi.org/10.3390/ijms241411373

Momčilović S, Bogdanović A, Milošević M, Mojsilović S, Marković D, Kočović DM, Vignjević-Petrinović S. Macrophages Provide Essential Support for Erythropoiesis, and Extracellular ATP Contributes to a Erythropoiesis-Supportive Microenvironment during Repeated Psychological Stress. in International Journal of Molecular Sciences. 2023;24(14):11373.
doi:10.3390/ijms241411373 .

Momčilović, Sanja, Bogdanović, Andrija, Milošević, Maja, Mojsilović, Slavko, Marković, Dragana, Kočović, Dušica M., Vignjević-Petrinović, Sanja, "Macrophages Provide Essential Support for Erythropoiesis, and Extracellular ATP Contributes to a Erythropoiesis-Supportive Microenvironment during Repeated Psychological Stress" in International Journal of Molecular Sciences, 24, no. 14 (2023):11373,
https://doi.org/10.3390/ijms241411373 . .

TY  - JOUR
AU  - Okić Đorđević, Ivana
AU  - Kukolj, Tamara
AU  - Živanović, Milena
AU  - Momčilović, Sanja
AU  - Obradović, Hristina
AU  - Petrović, Anđelija
AU  - Mojsilović, Slavko
AU  - Trivanović, Drenka
AU  - Jauković, Aleksandra
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1346
AB  - Periodontitis (PD) is a degenerative, bacteria-induced chronic disease of periodontium causing bone resorption and teeth loss. It includes a strong reaction of immune cells through the secretion of proinflammatory factors such as Interleukin-17 (IL-17). PD treatment may consider systemic oral antibiotics application, including doxycycline (Dox), exhibiting antibacterial and anti-inflammatory properties along with supportive activity in wound healing, thus affecting alveolar bone metabolism. In the present study, we aimed to determine whether Dox can affect the regenerative potential of periodontal ligament mesenchymal stem cells (PDLSCs) modulated by IL-17 in terms of cell migration, osteogenic potential, bioenergetics and expression of extracellular matrix metalloproteinase 2 (MMP-2). Our findings indicate that Dox reduces the stimulatory effect of IL-17 on migration and MMP-2 expression in PDLSCs. Furthermore, Dox stimulates osteogenic differentiation of PDLSCs, annulling the inhibitory effect of IL-17 on PDLSCs osteogenesis. In addition, analyses of mitochondrial respiration reveal that Dox decreases oxygen consumption rate in PDLSCs exposed to IL-17, suggesting that changes in metabolic performance can be involved in Dox-mediated effects on PDLSCs. The pro-regenerative properties of Dox in inflammatory microenvironment candidates Dox in terms of regenerative therapy of PD-affected periodontium are observed.
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Biomolecules
T2  - Biomolecules
T1  - The Role of Doxycycline and IL-17 in Regenerative Potential of Periodontal Ligament Stem Cells: Implications in Periodontitis
IS  - 10
SP  - 1437
VL  - 13
DO  - 10.3390/biom13101437
ER  - 

@article{
author = "Okić Đorđević, Ivana and Kukolj, Tamara and Živanović, Milena and Momčilović, Sanja and Obradović, Hristina and Petrović, Anđelija and Mojsilović, Slavko and Trivanović, Drenka and Jauković, Aleksandra",
year = "2023",
abstract = "Periodontitis (PD) is a degenerative, bacteria-induced chronic disease of periodontium causing bone resorption and teeth loss. It includes a strong reaction of immune cells through the secretion of proinflammatory factors such as Interleukin-17 (IL-17). PD treatment may consider systemic oral antibiotics application, including doxycycline (Dox), exhibiting antibacterial and anti-inflammatory properties along with supportive activity in wound healing, thus affecting alveolar bone metabolism. In the present study, we aimed to determine whether Dox can affect the regenerative potential of periodontal ligament mesenchymal stem cells (PDLSCs) modulated by IL-17 in terms of cell migration, osteogenic potential, bioenergetics and expression of extracellular matrix metalloproteinase 2 (MMP-2). Our findings indicate that Dox reduces the stimulatory effect of IL-17 on migration and MMP-2 expression in PDLSCs. Furthermore, Dox stimulates osteogenic differentiation of PDLSCs, annulling the inhibitory effect of IL-17 on PDLSCs osteogenesis. In addition, analyses of mitochondrial respiration reveal that Dox decreases oxygen consumption rate in PDLSCs exposed to IL-17, suggesting that changes in metabolic performance can be involved in Dox-mediated effects on PDLSCs. The pro-regenerative properties of Dox in inflammatory microenvironment candidates Dox in terms of regenerative therapy of PD-affected periodontium are observed.",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Biomolecules, Biomolecules",
title = "The Role of Doxycycline and IL-17 in Regenerative Potential of Periodontal Ligament Stem Cells: Implications in Periodontitis",
number = "10",
pages = "1437",
volume = "13",
doi = "10.3390/biom13101437"
}

Okić Đorđević, I., Kukolj, T., Živanović, M., Momčilović, S., Obradović, H., Petrović, A., Mojsilović, S., Trivanović, D.,& Jauković, A.. (2023). The Role of Doxycycline and IL-17 in Regenerative Potential of Periodontal Ligament Stem Cells: Implications in Periodontitis. in Biomolecules
Multidisciplinary Digital Publishing Institute (MDPI)., 13(10), 1437.
https://doi.org/10.3390/biom13101437

Okić Đorđević I, Kukolj T, Živanović M, Momčilović S, Obradović H, Petrović A, Mojsilović S, Trivanović D, Jauković A. The Role of Doxycycline and IL-17 in Regenerative Potential of Periodontal Ligament Stem Cells: Implications in Periodontitis. in Biomolecules. 2023;13(10):1437.
doi:10.3390/biom13101437 .

Okić Đorđević, Ivana, Kukolj, Tamara, Živanović, Milena, Momčilović, Sanja, Obradović, Hristina, Petrović, Anđelija, Mojsilović, Slavko, Trivanović, Drenka, Jauković, Aleksandra, "The Role of Doxycycline and IL-17 in Regenerative Potential of Periodontal Ligament Stem Cells: Implications in Periodontitis" in Biomolecules, 13, no. 10 (2023):1437,
https://doi.org/10.3390/biom13101437 . .

TY  - CHAP
AU  - Kapor, Sunčica
AU  - Momčilović, Sanja
AU  - Kapor, Slobodan
AU  - Mojsilović, Slavko
AU  - Radojković, Milica
AU  - Apostolović, Milica
AU  - Filipović, Branka
AU  - Gotić, Mirjana
AU  - Čokić, Vladan
AU  - Santibanez, Juan F.
AU  - Simon, Felipe
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1391
AB  - The Philadelphia-negative myeloproliferative neoplasms (MPNs), defined as clonal disorders of the hematopoietic stem cells, are characterized by the proliferation of mature myeloid cells in the bone marrow and a chronic inflammatory status impacting the initiation, progression, and symptomatology of the malignancies. There are three main entities defined as essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (PMF), and genetically classified by JAK2V617F, CALR, or MPL mutations. In MPNs, due to the overproduction of inflammatory cytokines by the neoplastic cells and non-transformed immune cells, chronic inflammation may provoke the generation and expansion of myeloid-derived suppressors cells (MDSCs) that highly influence the adaptive immune response. Although peripheral blood MDSC levels are elevated, their frequency in the bone marrow of MPNs patients is not well elucidated yet. Our results indicated increased levels of total (T)-MDSCs (CD33+HLA-DR−/low) and polymorphonuclear (PMN)-MDSCs (CD33+/HLA-DRlow/CD15+/CD14−) in the bone marrow and peripheral blood of all three types of MPNs malignancies. However, these bone marrow MDSCs-increased frequencies did not correlate with the clinical parameters, such as hepatomegaly, leukocytes, hemoglobin, or platelet levels, or with JAK2 and CALR mutations. Besides, bone marrow MDSCs, from ET, PV, and PMF patients, exhibited immunosuppressive function, determined as T-cell proliferation inhibition. Notably, the highest T-MDSCs and PMN-MDSC levels were found in PMF samples, and the increased MDSCs frequency strongly correlated with the degree of myelofibrosis. Thus, these data together indicate that the immunosuppressive MDSCs population is increased in the bone marrow of MPNs patients and may be implicated in generating a fibrotic microenvironment.
PB  - Springer Nature
T2  - Advances in Molecular Pathology
T1  - Increase in Frequency of Myeloid-Derived Suppressor Cells in the Bone Marrow of Myeloproliferative Neoplasm: Potential Implications in Myelofibrosis
EP  - 290
SP  - 273
VL  - 1408
DO  - 10.1007/978-3-031-26163-3_15
ER  - 

@inbook{
author = "Kapor, Sunčica and Momčilović, Sanja and Kapor, Slobodan and Mojsilović, Slavko and Radojković, Milica and Apostolović, Milica and Filipović, Branka and Gotić, Mirjana and Čokić, Vladan and Santibanez, Juan F. and Simon, Felipe",
year = "2023",
abstract = "The Philadelphia-negative myeloproliferative neoplasms (MPNs), defined as clonal disorders of the hematopoietic stem cells, are characterized by the proliferation of mature myeloid cells in the bone marrow and a chronic inflammatory status impacting the initiation, progression, and symptomatology of the malignancies. There are three main entities defined as essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (PMF), and genetically classified by JAK2V617F, CALR, or MPL mutations. In MPNs, due to the overproduction of inflammatory cytokines by the neoplastic cells and non-transformed immune cells, chronic inflammation may provoke the generation and expansion of myeloid-derived suppressors cells (MDSCs) that highly influence the adaptive immune response. Although peripheral blood MDSC levels are elevated, their frequency in the bone marrow of MPNs patients is not well elucidated yet. Our results indicated increased levels of total (T)-MDSCs (CD33+HLA-DR−/low) and polymorphonuclear (PMN)-MDSCs (CD33+/HLA-DRlow/CD15+/CD14−) in the bone marrow and peripheral blood of all three types of MPNs malignancies. However, these bone marrow MDSCs-increased frequencies did not correlate with the clinical parameters, such as hepatomegaly, leukocytes, hemoglobin, or platelet levels, or with JAK2 and CALR mutations. Besides, bone marrow MDSCs, from ET, PV, and PMF patients, exhibited immunosuppressive function, determined as T-cell proliferation inhibition. Notably, the highest T-MDSCs and PMN-MDSC levels were found in PMF samples, and the increased MDSCs frequency strongly correlated with the degree of myelofibrosis. Thus, these data together indicate that the immunosuppressive MDSCs population is increased in the bone marrow of MPNs patients and may be implicated in generating a fibrotic microenvironment.",
publisher = "Springer Nature",
journal = "Advances in Molecular Pathology",
booktitle = "Increase in Frequency of Myeloid-Derived Suppressor Cells in the Bone Marrow of Myeloproliferative Neoplasm: Potential Implications in Myelofibrosis",
pages = "290-273",
volume = "1408",
doi = "10.1007/978-3-031-26163-3_15"
}

Kapor, S., Momčilović, S., Kapor, S., Mojsilović, S., Radojković, M., Apostolović, M., Filipović, B., Gotić, M., Čokić, V., Santibanez, J. F.,& Simon, F.. (2023). Increase in Frequency of Myeloid-Derived Suppressor Cells in the Bone Marrow of Myeloproliferative Neoplasm: Potential Implications in Myelofibrosis. in Advances in Molecular Pathology
Springer Nature., 1408, 273-290.
https://doi.org/10.1007/978-3-031-26163-3_15

Kapor S, Momčilović S, Kapor S, Mojsilović S, Radojković M, Apostolović M, Filipović B, Gotić M, Čokić V, Santibanez JF, Simon F. Increase in Frequency of Myeloid-Derived Suppressor Cells in the Bone Marrow of Myeloproliferative Neoplasm: Potential Implications in Myelofibrosis. in Advances in Molecular Pathology. 2023;1408:273-290.
doi:10.1007/978-3-031-26163-3_15 .

Kapor, Sunčica, Momčilović, Sanja, Kapor, Slobodan, Mojsilović, Slavko, Radojković, Milica, Apostolović, Milica, Filipović, Branka, Gotić, Mirjana, Čokić, Vladan, Santibanez, Juan F., Simon, Felipe, "Increase in Frequency of Myeloid-Derived Suppressor Cells in the Bone Marrow of Myeloproliferative Neoplasm: Potential Implications in Myelofibrosis" in Advances in Molecular Pathology, 1408 (2023):273-290,
https://doi.org/10.1007/978-3-031-26163-3_15 . .

TY  - CONF
AU  - Okić Đorđević, Ivana
AU  - Kukolj, Tamara
AU  - Živanović, Milena
AU  - Momčilović, Sanja
AU  - Obradović, Hristina
AU  - Petrović, Anđelija
AU  - Mojsilović, Slavko
AU  - Trivanović, Drenka
AU  - Jauković, Aleksandra
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1406
AB  - Parodontopatija je hronično progresivno inflamatorno oboljenje tkiva parodoncijuma uzrokovano bakterijama zubnog plaka. Destrukcija parodoncijuma je posledica prekomerne aktivacije inflamatornog odgovora domaćina na bakterijsku infekciju i posledične produkcije citokina uključujući Interleukin-17 (IL-17). Lečenje parodontopatije podrazumeva i sistemsku primenu oralnih antibiotika poput doksociklina. Ovaj antibiotik iz klase tetraciklina ispoljava kako antibakterijska, tako i antiinflamatorna svojstva, a poznato je da utiče i na reparaciju tkiva i metabolizam alveolarnih kostiju. 
Cilj ove studije je bio da utvrdimo da li doksociklin utiče na regenerativni potencijal mezenhimskih matičnih ćelija periodoncijuma (PDL-MMĆ) tretiranih sa IL-17. Naši rezultati su pokazali da doksociklin značajno smanjuje stimulativni efekat IL-17 na migraciju i ekspresiju matriksne metaloproteinaze 2 u PDL-MMĆ. Pored toga, doksociklin stimuliše osteogenu diferencijaciju PDL-MMĆ poništavajući inhibitorni efekat IL-17 na osteogenezu ovih ćelija. Analize ćelijske respiracije su otkrile da doksociklin smanjuje stopu potrošnje kiseonika i mitohondrijalnu biogenezu u IL-17-tretiranim PDL-MMĆ. Pokazana pro-regenerativna svojstva doksociklina u inflamatornom okruženju ukazuju na potencijal njegove primene u razvoju novih pristupa za terapiju parodontopatije.
PB  - Beograd: Srpska akademija nauka i umetnosti, Odeljenje medicinskih nauka SANU, Odbor za imunologiju i alergologiju i Društvo imunologa Srbije
C3  - Naučni skup Svetski dan imunologije, 27. april 2023. godine Svečana sala SANU - Knjiga sažetaka
T1  - Uticaj Doksiciklina na regenerativni potencijal mezenhimskih matičnih ćelija periodoncijuma
UR  - https://hdl.handle.net/21.15107/rcub_rimi_1406
ER  - 

@conference{
author = "Okić Đorđević, Ivana and Kukolj, Tamara and Živanović, Milena and Momčilović, Sanja and Obradović, Hristina and Petrović, Anđelija and Mojsilović, Slavko and Trivanović, Drenka and Jauković, Aleksandra",
year = "2023",
abstract = "Parodontopatija je hronično progresivno inflamatorno oboljenje tkiva parodoncijuma uzrokovano bakterijama zubnog plaka. Destrukcija parodoncijuma je posledica prekomerne aktivacije inflamatornog odgovora domaćina na bakterijsku infekciju i posledične produkcije citokina uključujući Interleukin-17 (IL-17). Lečenje parodontopatije podrazumeva i sistemsku primenu oralnih antibiotika poput doksociklina. Ovaj antibiotik iz klase tetraciklina ispoljava kako antibakterijska, tako i antiinflamatorna svojstva, a poznato je da utiče i na reparaciju tkiva i metabolizam alveolarnih kostiju. 
Cilj ove studije je bio da utvrdimo da li doksociklin utiče na regenerativni potencijal mezenhimskih matičnih ćelija periodoncijuma (PDL-MMĆ) tretiranih sa IL-17. Naši rezultati su pokazali da doksociklin značajno smanjuje stimulativni efekat IL-17 na migraciju i ekspresiju matriksne metaloproteinaze 2 u PDL-MMĆ. Pored toga, doksociklin stimuliše osteogenu diferencijaciju PDL-MMĆ poništavajući inhibitorni efekat IL-17 na osteogenezu ovih ćelija. Analize ćelijske respiracije su otkrile da doksociklin smanjuje stopu potrošnje kiseonika i mitohondrijalnu biogenezu u IL-17-tretiranim PDL-MMĆ. Pokazana pro-regenerativna svojstva doksociklina u inflamatornom okruženju ukazuju na potencijal njegove primene u razvoju novih pristupa za terapiju parodontopatije.",
publisher = "Beograd: Srpska akademija nauka i umetnosti, Odeljenje medicinskih nauka SANU, Odbor za imunologiju i alergologiju i Društvo imunologa Srbije",
journal = "Naučni skup Svetski dan imunologije, 27. april 2023. godine Svečana sala SANU - Knjiga sažetaka",
title = "Uticaj Doksiciklina na regenerativni potencijal mezenhimskih matičnih ćelija periodoncijuma",
url = "https://hdl.handle.net/21.15107/rcub_rimi_1406"
}

Okić Đorđević, I., Kukolj, T., Živanović, M., Momčilović, S., Obradović, H., Petrović, A., Mojsilović, S., Trivanović, D.,& Jauković, A.. (2023). Uticaj Doksiciklina na regenerativni potencijal mezenhimskih matičnih ćelija periodoncijuma. in Naučni skup Svetski dan imunologije, 27. april 2023. godine Svečana sala SANU - Knjiga sažetaka
Beograd: Srpska akademija nauka i umetnosti, Odeljenje medicinskih nauka SANU, Odbor za imunologiju i alergologiju i Društvo imunologa Srbije..
https://hdl.handle.net/21.15107/rcub_rimi_1406

Okić Đorđević I, Kukolj T, Živanović M, Momčilović S, Obradović H, Petrović A, Mojsilović S, Trivanović D, Jauković A. Uticaj Doksiciklina na regenerativni potencijal mezenhimskih matičnih ćelija periodoncijuma. in Naučni skup Svetski dan imunologije, 27. april 2023. godine Svečana sala SANU - Knjiga sažetaka. 2023;.
https://hdl.handle.net/21.15107/rcub_rimi_1406 .

Okić Đorđević, Ivana, Kukolj, Tamara, Živanović, Milena, Momčilović, Sanja, Obradović, Hristina, Petrović, Anđelija, Mojsilović, Slavko, Trivanović, Drenka, Jauković, Aleksandra, "Uticaj Doksiciklina na regenerativni potencijal mezenhimskih matičnih ćelija periodoncijuma" in Naučni skup Svetski dan imunologije, 27. april 2023. godine Svečana sala SANU - Knjiga sažetaka (2023),
https://hdl.handle.net/21.15107/rcub_rimi_1406 .

TY  - JOUR
AU  - Vignjević-Petrinović, Sanja
AU  - Milošević, Maja
AU  - Marković, Dragana
AU  - Momčilović, Sanja
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1300
AB  - Stress is an integral part of life. While acute responses to stress are generally regarded as beneficial in dealing with immediate threats, chronic exposure to threatening stimuli exerts deleterious effects and can be either a contributing or an aggravating factor for many chronic diseases including cancer. Chronic psychological stress has been identified as a significant factor contributing to the development and progression of cancer, but the mechanisms that link chronic stress to cancer remain incompletely understood. Psychological stressors initiate multiple physiological responses that result in the activation of the hypothalamic-pituitary-adrenal (HPA) axis, sympathetic nervous system, and the subsequent changes in immune function. Chronic stress exposure disrupts the homeostatic communication between the neuroendocrine and immune systems, shifting immune signaling toward a proinflammatory state. Stress-induced chronic low-grade inflammation and a decline in immune surveillance are both implicated in cancer development and progression. Conversely, tumor-induced inflammatory cytokines, apart from driving a tumor-supportive inflammatory microenvironment, can also exert their biological actions distantly via circulation and therefore adversely affect the stress response. In this minireview, we summarize the current findings on the relationship between stress and cancer, focusing on the role of inflammation in stress-induced neuroendocrine-immune crosstalk. We also discuss the underlying mechanisms and their potential for cancer treatment and prevention.
PB  - Frontiers Media S.A.
T2  - Frontiers in Physiology
T1  - Interplay between stress and cancer—A focus on inflammation
SP  - 1119095
VL  - 14
DO  - 10.3389/fphys.2023.1119095
ER  - 

@article{
author = "Vignjević-Petrinović, Sanja and Milošević, Maja and Marković, Dragana and Momčilović, Sanja",
year = "2023",
abstract = "Stress is an integral part of life. While acute responses to stress are generally regarded as beneficial in dealing with immediate threats, chronic exposure to threatening stimuli exerts deleterious effects and can be either a contributing or an aggravating factor for many chronic diseases including cancer. Chronic psychological stress has been identified as a significant factor contributing to the development and progression of cancer, but the mechanisms that link chronic stress to cancer remain incompletely understood. Psychological stressors initiate multiple physiological responses that result in the activation of the hypothalamic-pituitary-adrenal (HPA) axis, sympathetic nervous system, and the subsequent changes in immune function. Chronic stress exposure disrupts the homeostatic communication between the neuroendocrine and immune systems, shifting immune signaling toward a proinflammatory state. Stress-induced chronic low-grade inflammation and a decline in immune surveillance are both implicated in cancer development and progression. Conversely, tumor-induced inflammatory cytokines, apart from driving a tumor-supportive inflammatory microenvironment, can also exert their biological actions distantly via circulation and therefore adversely affect the stress response. In this minireview, we summarize the current findings on the relationship between stress and cancer, focusing on the role of inflammation in stress-induced neuroendocrine-immune crosstalk. We also discuss the underlying mechanisms and their potential for cancer treatment and prevention.",
publisher = "Frontiers Media S.A.",
journal = "Frontiers in Physiology",
title = "Interplay between stress and cancer—A focus on inflammation",
pages = "1119095",
volume = "14",
doi = "10.3389/fphys.2023.1119095"
}

Vignjević-Petrinović, S., Milošević, M., Marković, D.,& Momčilović, S.. (2023). Interplay between stress and cancer—A focus on inflammation. in Frontiers in Physiology
Frontiers Media S.A.., 14, 1119095.
https://doi.org/10.3389/fphys.2023.1119095

Vignjević-Petrinović S, Milošević M, Marković D, Momčilović S. Interplay between stress and cancer—A focus on inflammation. in Frontiers in Physiology. 2023;14:1119095.
doi:10.3389/fphys.2023.1119095 .

Vignjević-Petrinović, Sanja, Milošević, Maja, Marković, Dragana, Momčilović, Sanja, "Interplay between stress and cancer—A focus on inflammation" in Frontiers in Physiology, 14 (2023):1119095,
https://doi.org/10.3389/fphys.2023.1119095 . .

TY  - JOUR
AU  - Vignjević-Petrinović, Sanja
AU  - Budeč, Mirela
AU  - Marković, Dragana
AU  - Mitrović-Ajtić, Olivera
AU  - Jovčić, Gordana
AU  - Milošević, Maja
AU  - Momčilović, Sanja
AU  - Čokić, Vladan
PY  - 2020
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1029
AB  - Anaemia occurs frequently in patients with heart failure and its current treatment lacks clear targets. Emerging evidence suggests that erythroid progenitor cell expansion is an integral part of physiological response to anaemia associated with chronic stress. Understanding the underlying mechanism may provide a novel approach to anaemia management. In this study, we aimed to examine a role for nitric oxide (NO) in the regulation of bone marrow erythroid progenitor response to chronic stress. For this purpose, adult male mice were subjected to 2 h daily restraint stress for 7 or 14 consecutive days. The role of NO was assessed by subcutaneous injection with NG-nitro-l-arginine methyl ester, 30 min prior to each restraint. Chronic exposure to stress resulted in significantly increased number of bone marrow erythroid progenitors, and blockade of NO biosynthesis prior to daily stress completely prevented stress-induced erythroid progenitor cell expansion. Furthermore, chronic stress exposure led to altered expression of neural, endothelial and inducible nitric oxide synthases (NOS) in the bone marrow, both on mRNA and protein level. Decreased expression of neural and endothelial NOS, as well as reduced expression of NF-kappaB/p65 in bone marrow nuclear cell fraction, was accompanied by elevated bone marrow expression of inducible NOS in chronically stressed animals. This is the first study to demonstrate a role for NO in adaptive response of erythroid progenitors to chronic stress. Targeting NO production may be beneficial to improve bone marrow dysfunction and reduced erythroid progenitor cell expansion in chronic heart failure patients.
PB  - Springer, New York
T2  - Histochemistry & Cell Biology
T1  - Nitric oxide-dependent expansion of erythroid progenitors in a murine model of chronic psychological stress
EP  - 468
IS  - 6
SP  - 457
VL  - 153
DO  - 10.1007/s00418-020-01856-y
ER  - 

@article{
author = "Vignjević-Petrinović, Sanja and Budeč, Mirela and Marković, Dragana and Mitrović-Ajtić, Olivera and Jovčić, Gordana and Milošević, Maja and Momčilović, Sanja and Čokić, Vladan",
year = "2020",
abstract = "Anaemia occurs frequently in patients with heart failure and its current treatment lacks clear targets. Emerging evidence suggests that erythroid progenitor cell expansion is an integral part of physiological response to anaemia associated with chronic stress. Understanding the underlying mechanism may provide a novel approach to anaemia management. In this study, we aimed to examine a role for nitric oxide (NO) in the regulation of bone marrow erythroid progenitor response to chronic stress. For this purpose, adult male mice were subjected to 2 h daily restraint stress for 7 or 14 consecutive days. The role of NO was assessed by subcutaneous injection with NG-nitro-l-arginine methyl ester, 30 min prior to each restraint. Chronic exposure to stress resulted in significantly increased number of bone marrow erythroid progenitors, and blockade of NO biosynthesis prior to daily stress completely prevented stress-induced erythroid progenitor cell expansion. Furthermore, chronic stress exposure led to altered expression of neural, endothelial and inducible nitric oxide synthases (NOS) in the bone marrow, both on mRNA and protein level. Decreased expression of neural and endothelial NOS, as well as reduced expression of NF-kappaB/p65 in bone marrow nuclear cell fraction, was accompanied by elevated bone marrow expression of inducible NOS in chronically stressed animals. This is the first study to demonstrate a role for NO in adaptive response of erythroid progenitors to chronic stress. Targeting NO production may be beneficial to improve bone marrow dysfunction and reduced erythroid progenitor cell expansion in chronic heart failure patients.",
publisher = "Springer, New York",
journal = "Histochemistry & Cell Biology",
title = "Nitric oxide-dependent expansion of erythroid progenitors in a murine model of chronic psychological stress",
pages = "468-457",
number = "6",
volume = "153",
doi = "10.1007/s00418-020-01856-y"
}

Vignjević-Petrinović, S., Budeč, M., Marković, D., Mitrović-Ajtić, O., Jovčić, G., Milošević, M., Momčilović, S.,& Čokić, V.. (2020). Nitric oxide-dependent expansion of erythroid progenitors in a murine model of chronic psychological stress. in Histochemistry & Cell Biology
Springer, New York., 153(6), 457-468.
https://doi.org/10.1007/s00418-020-01856-y

Vignjević-Petrinović S, Budeč M, Marković D, Mitrović-Ajtić O, Jovčić G, Milošević M, Momčilović S, Čokić V. Nitric oxide-dependent expansion of erythroid progenitors in a murine model of chronic psychological stress. in Histochemistry & Cell Biology. 2020;153(6):457-468.
doi:10.1007/s00418-020-01856-y .

Vignjević-Petrinović, Sanja, Budeč, Mirela, Marković, Dragana, Mitrović-Ajtić, Olivera, Jovčić, Gordana, Milošević, Maja, Momčilović, Sanja, Čokić, Vladan, "Nitric oxide-dependent expansion of erythroid progenitors in a murine model of chronic psychological stress" in Histochemistry & Cell Biology, 153, no. 6 (2020):457-468,
https://doi.org/10.1007/s00418-020-01856-y . .

TY  - CONF
AU  - Kovačić, Marijana
AU  - Mitrović-Ajtić, Olivera
AU  - Beleslin-Čokić, Bojana
AU  - Diklić, Miloš
AU  - Subotički, Tijana
AU  - Đikić, Dragoslava
AU  - Momčilović, Sanja
AU  - Leković, Danijela
AU  - Gotić, Mirjana
AU  - Čokić, Vladan
PY  - 2017
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/780
PB  - Ferrata Storti Foundation, Pavia
C3  - Haematologica
T1  - S100a8/9 activation of mapk pathway is supported by its receptors rage and tlr4 in polycythemia vera
EP  - 540
SP  - 540
VL  - 102
UR  - https://hdl.handle.net/21.15107/rcub_rimi_780
ER  - 

@conference{
author = "Kovačić, Marijana and Mitrović-Ajtić, Olivera and Beleslin-Čokić, Bojana and Diklić, Miloš and Subotički, Tijana and Đikić, Dragoslava and Momčilović, Sanja and Leković, Danijela and Gotić, Mirjana and Čokić, Vladan",
year = "2017",
publisher = "Ferrata Storti Foundation, Pavia",
journal = "Haematologica",
title = "S100a8/9 activation of mapk pathway is supported by its receptors rage and tlr4 in polycythemia vera",
pages = "540-540",
volume = "102",
url = "https://hdl.handle.net/21.15107/rcub_rimi_780"
}

Kovačić, M., Mitrović-Ajtić, O., Beleslin-Čokić, B., Diklić, M., Subotički, T., Đikić, D., Momčilović, S., Leković, D., Gotić, M.,& Čokić, V.. (2017). S100a8/9 activation of mapk pathway is supported by its receptors rage and tlr4 in polycythemia vera. in Haematologica
Ferrata Storti Foundation, Pavia., 102, 540-540.
https://hdl.handle.net/21.15107/rcub_rimi_780

Kovačić M, Mitrović-Ajtić O, Beleslin-Čokić B, Diklić M, Subotički T, Đikić D, Momčilović S, Leković D, Gotić M, Čokić V. S100a8/9 activation of mapk pathway is supported by its receptors rage and tlr4 in polycythemia vera. in Haematologica. 2017;102:540-540.
https://hdl.handle.net/21.15107/rcub_rimi_780 .

Kovačić, Marijana, Mitrović-Ajtić, Olivera, Beleslin-Čokić, Bojana, Diklić, Miloš, Subotički, Tijana, Đikić, Dragoslava, Momčilović, Sanja, Leković, Danijela, Gotić, Mirjana, Čokić, Vladan, "S100a8/9 activation of mapk pathway is supported by its receptors rage and tlr4 in polycythemia vera" in Haematologica, 102 (2017):540-540,
https://hdl.handle.net/21.15107/rcub_rimi_780 .