Pretraživanje
Prikaz rezultata 11-20 od 134
Experimental and systems biology studies of the molecular basis for the radioresistance of prostate carcinoma cells
(Springer, New York, 2008)
Molecular mechanisms for the gamma-ionizing radiation (IR) resistance of human prostate cancer cells, PC-3, are not quite clear. Since the low-LET-IR effects are primarily manifested by the generation of reactive oxygen ...
Evidence for an association of high levels of endogenous Acetyl-Ser-Asp-Lys-Pro, a potent mediator of angiogenesis, with acute myeloid leukemia development
(Taylor & Francis Ltd, Abingdon, 2006)
Evidence from clinical and laboratory studies suggests that angiogenesis is important in the progression of solid tumours and hematologic malignancies. We have shown that the naturally occurring tetrapeptide Acetyl-Ser-Asp-Lys-Pro ...
Alginate microbeads as a cell support for cartilage tissue engineering: Bioreactor studies
(Trans Tech Publications Ltd, Durnten-Zurich, 2007)
Alginate was shown to be a suitable support for entrapment and cultivation of chondrocytes and bone marrow stromal cells, which under appropriate in vitro conditions synthesized cartilaginous components. The main limitation ...
Hydroxyurea nitrosylates and activates soluble guanylyl cyclase in human erythroid cells
(Elsevier Science Inc, New York, 2007)
Effects of Nitric Oxide on Red Blood Cell Development and Phenotype
(Current Topics in Developmental Biology, 2008)
Nitric oxide (NO) is a diffusible free radical generated primarily by NO synthases (NOS), isoenzymes that convert the l-arginine and molecular oxygen to citrulline and NO in cells. Endothelial cells as well as macrophages, ...
Hydroxyurea induces the eNOS-cGMP pathway in endothelial cells
(Amer Soc Hematology, Washington, 2006)
Hydroxyurea is a cell-cycle-specific drug that has been used to treat myeloproliferative diseases and sickle cell anemia. We have recently shown that hydroxyurea, like nitric oxide (NO)-donor compounds, increased cGMP ...
Hydroxyurea increases eNOS protein levels through inhibition of proteasome activity
(Academic Press Inc Elsevier Science, San Diego, 2007)
Recent reports have identified the proteasome as the primary degradation pathway for inducible, neuronal and endothelial nitric oxide synthase (NOS). We have demonstrated that hydroxyurea increased nitric oxide (NO) ...
Comparative effects of aspirin and NO-releasing aspirins on differentiation, maturation and function of human monocyte-derived dendritic cells in vitro
(Elsevier Science Bv, Amsterdam, 2009)
Acetylsalicilyc acid (aspirin, ASA) is a well known anti-inflammatory drug with immunomodulatory properties. NO-releasing aspirins (NO-ASA) are new compounds with anti-inflammatory properties. We studied the effects of ASA ...
Muscle strength testing: evaluation of tests of explosive force production
(Springer, New York, 2004)
The purpose of the study was to evaluate four tests of explosive force production (EFP). Specifically, the main aims of the study were to assess the reliability of different EFP tests, to examine their relationship with ...
Influence of microenvironmental conditions on hybridoma cell growth inside the alginate-poly-L-lysine microcapsule
(Elsevier Sci Ltd, Oxford, 2007)
A mathematical model was formulated to describe hybridoma cell growth within the alginate-poly-L-lysine (alginate-PLL) microcapsules during air-lift bioreactor cultivation. Model development was based on experimentally ...