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JAK2-mutant hematopoietic cells display metabolic alterations that can be targeted to treat myeloproliferative neoplasms
(Amer Soc Hematology, Washington, 2019)
Increased energy requirement and metabolic reprogramming are hallmarks of cancer cells. We show that metabolic alterations in hematopoietic cells are fundamental to the pathogenesis of mutant JAK2-driven myeloproliferative ...
Analysis of host cell binding specificity mediated by the tp0136 adhesin of the syphilis agent treponema pallidum subsp. Pallidum
(Public Library of Science (PLoS), 2019)
Background Syphilis affects approximately 11 million people each year globally, and is the third most prevalent sexually transmitted bacterial infection in the United States. Inability to independently culture and genetically ...
Synthesis, characterization and biological study of new dinuclear zinc(ii) and nickel(ii) octaaza macrocyclic complexes
(Soc Chemists Technologists Madeconia, Skopje, 2019)
Two new nitrato complexes of zinc and nickel with 1,4,8,11-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc), have been synthesized and characterized. The IR spectral peaks showed that the coordinated and ...
Toxoplasma gondii in beef consumed in France: Regional variation in seroprevalence and parasite isolation
(EDP Sciences, 2019)
In France, the consumption of cattle and sheep meat appears to be a risk factor for infection of pregnant women with Toxoplasma gondii. Several nation-wide surveys in France have investigated the prevalence of T. gondii ...
Protozoan parasite babesia microti subverts adaptive immunity and enhances lyme disease severity
(Frontiers in Microbiology, 2019)
Lyme disease is the most prominent tick-borne disease in the United States. Co-infections with the tick-transmitted pathogens Babesia microti and Borrelia burgdorferi sensu stricto are becoming a serious health problem. ...
Modulation of hepatic inflammation and energy-sensing pathways in the rat liver by high-fructose diet and chronic stress
(Springer Heidelberg, Heidelberg, 2019)
Purpose High-fructose consumption and chronic stress are both associated with metabolic inflammation and insulin resistance. Recently, disturbed activity of energy sensor AMP-activated protein kinase (AMPK) was recognized ...
Approaches to mimic the complexity of the skeletal mesenchymal stem/stromal cell niche in vitro
(Ao Research Institute Davos-Ari, Davos, 2019)
Mesenchymal stem/stromal cells (MSCs) are an essential element of most modem tissue engineering and regenerative medicine approaches due to their multipotency and immunoregulatory functions. Despite the prospective value ...
Sport-Specific Warm-Up Attenuates Static Stretching-Induced Negative Effects on Vertical Jump But Not Neuromuscular Excitability in Basketball Players
(Journal Sports Science & Medicine, Bursa, 2019)
The purpose of this study was to examine the acute effects of static stretching (SS) and dynamic stretching (DS), alone and in combination with specific basketball warm-up (SBWU), on the neuromuscular excitability and ...
General psychopathology and impulsivity as the pretreatment predictors of medical nutrition therapy outcome in the overweight and obese women / Opšta psihopatologija i impulsivnost kao pokazatelji potencijalnog ishoda medicinske nutritivne terapije kod predgojaznih i gojaznih žena
(Vojnomedicinska akademija - Institut za naučne informacije, Beograd, 2019)
Background/Aim. Obesity is the chronic disease and health threatening condition. The number of obese people in the world has taken epidemic conditions. Medical nutritional therapy is the first choice in the treatment of ...
Serum C-reactive protein and nutritional parameters in hemodialysis patients / Serumski C-reaktivni protein i nutritivni parametri kod bolesnika na hemodijalizi
(Vojnomedicinska akademija - Institut za naučne informacije, Beograd, 2019)
Background/Aim. Inflammation is the most important factor in the genesis of vascular complication in the endstage renal disease. The serum C-reactive protein (CRP) level is a sensitive marker of systemic inflammation as ...