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Approaches to mimic the complexity of the skeletal mesenchymal stem/stromal cell niche in vitro

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2019
936.pdf (953.2Kb)
Authors
Pereira, A. R.
Trivanović, Drenka
Herrmann, Marietta
Article (Published version)
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Abstract
Mesenchymal stem/stromal cells (MSCs) are an essential element of most modem tissue engineering and regenerative medicine approaches due to their multipotency and immunoregulatory functions. Despite the prospective value of MSCs for the clinics, the stem cells community is questioning their developmental origin, in vivo localization, identification, and regenerative potential after several years of far-reaching research in the field. Although several major progresses have been made in mimicking the complexity of the MSC niche in vitro, there is need for comprehensive studies of fundamental mechanisms triggered by microenvironmental cues before moving to regenerative medicine cell therapy applications. The present comprehensive review extensively discusses the microenvironmental cues that influence MSC phenotype and function in health and disease - including cellular, chemical and physical interactions. The most recent and relevant illustrative examples of novel bioengineering approache...s to mimic biological, chemical, and mechanical microenvironmental signals present in the native MSC niche are summarized, with special emphasis on the forefront techniques to achieve bio-chemical complexity and dynamic cultures. In particular, the skeletal MSC niche and applications focusing on the bone regenerative potential of MSC are addressed. The aim of the review was to recognize the limitations of the current MSC niche in vitro models and to identify potential opportunities to fill the bridge between fundamental science and clinical application of MSCs.

Keywords:
Mesenchymal stem/stromal cells / skeletal progenitor cells / niche / in vitro models / bone / tissue engineering
Source:
European Cells & Materials, 2019, 37, 88-112
Publisher:
  • Ao Research Institute Davos-Ari, Davos
Funding / projects:
  • Interdisciplinary Center for Clinical Research (IZKF) Wuerzburg, Germany [D-361]

DOI: 10.22203/eCM.v037a07

ISSN: 1473-2262

PubMed: 30742298

WoS: 000463430000007

Scopus: 2-s2.0-85061268226
[ Google Scholar ]
4
4
URI
http://rimi.imi.bg.ac.rs/handle/123456789/939
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
Institut za medicinska istraživanja
TY  - JOUR
AU  - Pereira, A. R.
AU  - Trivanović, Drenka
AU  - Herrmann, Marietta
PY  - 2019
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/939
AB  - Mesenchymal stem/stromal cells (MSCs) are an essential element of most modem tissue engineering and regenerative medicine approaches due to their multipotency and immunoregulatory functions. Despite the prospective value of MSCs for the clinics, the stem cells community is questioning their developmental origin, in vivo localization, identification, and regenerative potential after several years of far-reaching research in the field. Although several major progresses have been made in mimicking the complexity of the MSC niche in vitro, there is need for comprehensive studies of fundamental mechanisms triggered by microenvironmental cues before moving to regenerative medicine cell therapy applications. The present comprehensive review extensively discusses the microenvironmental cues that influence MSC phenotype and function in health and disease - including cellular, chemical and physical interactions. The most recent and relevant illustrative examples of novel bioengineering approaches to mimic biological, chemical, and mechanical microenvironmental signals present in the native MSC niche are summarized, with special emphasis on the forefront techniques to achieve bio-chemical complexity and dynamic cultures. In particular, the skeletal MSC niche and applications focusing on the bone regenerative potential of MSC are addressed. The aim of the review was to recognize the limitations of the current MSC niche in vitro models and to identify potential opportunities to fill the bridge between fundamental science and clinical application of MSCs.
PB  - Ao Research Institute Davos-Ari, Davos
T2  - European Cells & Materials
T1  - Approaches to mimic the complexity of the skeletal mesenchymal stem/stromal cell niche in vitro
EP  - 112
SP  - 88
VL  - 37
DO  - 10.22203/eCM.v037a07
ER  - 
@article{
author = "Pereira, A. R. and Trivanović, Drenka and Herrmann, Marietta",
year = "2019",
abstract = "Mesenchymal stem/stromal cells (MSCs) are an essential element of most modem tissue engineering and regenerative medicine approaches due to their multipotency and immunoregulatory functions. Despite the prospective value of MSCs for the clinics, the stem cells community is questioning their developmental origin, in vivo localization, identification, and regenerative potential after several years of far-reaching research in the field. Although several major progresses have been made in mimicking the complexity of the MSC niche in vitro, there is need for comprehensive studies of fundamental mechanisms triggered by microenvironmental cues before moving to regenerative medicine cell therapy applications. The present comprehensive review extensively discusses the microenvironmental cues that influence MSC phenotype and function in health and disease - including cellular, chemical and physical interactions. The most recent and relevant illustrative examples of novel bioengineering approaches to mimic biological, chemical, and mechanical microenvironmental signals present in the native MSC niche are summarized, with special emphasis on the forefront techniques to achieve bio-chemical complexity and dynamic cultures. In particular, the skeletal MSC niche and applications focusing on the bone regenerative potential of MSC are addressed. The aim of the review was to recognize the limitations of the current MSC niche in vitro models and to identify potential opportunities to fill the bridge between fundamental science and clinical application of MSCs.",
publisher = "Ao Research Institute Davos-Ari, Davos",
journal = "European Cells & Materials",
title = "Approaches to mimic the complexity of the skeletal mesenchymal stem/stromal cell niche in vitro",
pages = "112-88",
volume = "37",
doi = "10.22203/eCM.v037a07"
}
Pereira, A. R., Trivanović, D.,& Herrmann, M.. (2019). Approaches to mimic the complexity of the skeletal mesenchymal stem/stromal cell niche in vitro. in European Cells & Materials
Ao Research Institute Davos-Ari, Davos., 37, 88-112.
https://doi.org/10.22203/eCM.v037a07
conv_4505
Pereira AR, Trivanović D, Herrmann M. Approaches to mimic the complexity of the skeletal mesenchymal stem/stromal cell niche in vitro. in European Cells & Materials. 2019;37:88-112.
doi:10.22203/eCM.v037a07
conv_4505 .
Pereira, A. R., Trivanović, Drenka, Herrmann, Marietta, "Approaches to mimic the complexity of the skeletal mesenchymal stem/stromal cell niche in vitro" in European Cells & Materials, 37 (2019):88-112,
https://doi.org/10.22203/eCM.v037a07 .,
conv_4505 .

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