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Rac1 modulates TGF-beta 1-mediated epithelial cell plasticity and MMP9 production in transformed keratinocytes
(Elsevier Science Bv, Amsterdam, 2010)
Transforming growth factor-beta 1 (TGF-beta 1) activates Rac1 GTPase in mouse transformed keratinocytes. Expression of a constitutively active Q61LRac1 mutant induced an epithelial to mesenchymal transition (EMT) linked ...
The importance of cardiovascular risk factors for thrombosis prediction in patients with essential thrombocythemia
(Humana Press Inc, Totowa, 2014)
The current widely accepted stratification defined by age and previous thrombosis in patients with essential thrombocythemia (ET) probably deserves deeper analysis. The aim of our study was to identify additional factors ...
Effects of Polyphenol-Rich Chokeberry Juice on Antioxidant/Pro-Oxidant Status in Healthy Subjects
(Mary Ann Liebert, Inc, New Rochelle, 2014)
Berry fruits are a rich source of polyphenols, especially anthocyanins: well-known potent anti-oxidant phytochemicals. The purpose of this study was to evaluate beneficial effects of long-term consumption of polyphenol-rich ...
Predictors of survival and cause of death in patients with essential thrombocythemia
(Wiley-Blackwell, Hoboken, 2015)
ObjectivesStandard risk stratification for overall survival (OS) in patients with essential thrombocythemia (ET) is based on advanced age and history of thrombotic events. Recently, International Prognostic Score for ET ...
Beneficial Effects of Polyphenol-Rich Chokeberry Juice Consumption on Blood Pressure Level and Lipid Status in Hypertensive Subjects
(Mary Ann Liebert, Inc, New Rochelle, 2015)
Epidemiological studies have shown a positive association between intake of foods rich in antioxidants and lower incidence of cardiovascular disease development. Polyphenols are considered the most abundant and important ...
Effect of carvedilol on pulse pressure and left ventricular hypertrophy in spontaneously hypertensive rats with adriamycin nephropathy
(Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux, 2009)
Recent studies indicated pulse pressure as a risk factor for left ventricular hypertrophy, myocardial infarction, congestive heart failure and stroke as well as chronic renal failure progression. The present study examined ...
EURRECA: development of tools to improve the alignment of micronutrient recommendations
(Nature Publishing Group, London, 2010)
Approaches through which reference values for micronutrients are derived, as well as the reference values themselves, vary considerably across countries. Harmonisation is needed to improve nutrition policy and public health ...
Contribution of comorbidities and grade of bone marrow fibrosis to the prognosis of survival in patients with primary myelofibrosis
(Humana Press Inc, Totowa, 2014)
The widely used current International Prognostic Scoring System (IPSS) for primary myelofibrosis (PMF) is based on clinical parameters. The objective of this study was to identify additional prognostic factors at the time ...
Mini-FLOTAC for counting Toxoplasma gondii oocysts from cat feces - Comparison with cell counting plates
(Academic Press Inc Elsevier Science, San Diego, 2014)
Oocysts of Toxoplasma gondii represent one of the most common environmental contaminants causing the zoonotic infection toxoplasmosis. The aim of the present study was to compare the Mini-FLOTAC device with traditional ...
Investigation into novel thiophene- and furan-based 4-amino-7-chloroquinolines afforded antimalarials that cure mice
(Pergamon-Elsevier Science Ltd, Oxford, 2015)
We herein report the design and synthesis of a novel series of thiophene-and furan-based aminoquinoline derivatives which were found to be potent antimalarials and inhibitors of b-hematin polymerization. Tested compounds ...