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Predictors of survival and cause of death in patients with essential thrombocythemia

Authorized Users Only
2015
Authors
Leković, Danijela
Gotić, Mirjana
Sefer, Dijana
Mitrović-Ajtić, Olivera
Čokić, Vladan
Milić, Nataša
Article (Published version)
Metadata
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Abstract
ObjectivesStandard risk stratification for overall survival (OS) in patients with essential thrombocythemia (ET) is based on advanced age and history of thrombotic events. Recently, International Prognostic Score for ET (IPSET) incorporated also leukocytosis in prognostic model. The aim of this study was to establish additional risk factors for OS in ET patients. MethodsAfter the median follow-up of 7yr, in 244 consecutive ET patients, 32 deaths were documented (13.2%). The 5- and 10-yr OS was 95.9% and 79.7%, respectively. Considered additional risk factors at diagnosis of ET were the presence of arterial hypertension, diabetes, hyperlipidemia, and smoking attitude. ResultsThe main cause of death in 75% of patients was cardiovascular (CV) comorbidity. Patients with CV risk factors had increased risk of death (HR=2.33). Cox regression model identified age, leukocytosis, presence of CV risk factors, and previous thrombosis as unfavorable predictors of survival. Based on these parameters..., four risk groups were defined, with significantly different survivals (P lt 0.001). Improved prognostic model displayed a better hazard ratio profile compared to the standard risk stratification and IPSET. ConclusionThe addition of CV risk factors allows better prognostic assessment by delineating the intermediate-risk category and improved identification of the high-risk patients.

Keywords:
myeloproliferative neoplasms / essential thrombocythemia / cardiovascular risk factors / prognosis / survival
Source:
European Journal of Haematology, 2015, 95, 5, 461-466
Publisher:
  • Wiley-Blackwell, Hoboken
Funding / projects:
  • The pathogenetic mechanism in hematological malignancies (RS-175053)

DOI: 10.1111/ejh.12517

ISSN: 0902-4441

PubMed: 25645731

WoS: 000363328800012

Scopus: 2-s2.0-84944512038
[ Google Scholar ]
9
6
URI
http://rimi.imi.bg.ac.rs/handle/123456789/615
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
Institut za medicinska istraživanja
TY  - JOUR
AU  - Leković, Danijela
AU  - Gotić, Mirjana
AU  - Sefer, Dijana
AU  - Mitrović-Ajtić, Olivera
AU  - Čokić, Vladan
AU  - Milić, Nataša
PY  - 2015
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/615
AB  - ObjectivesStandard risk stratification for overall survival (OS) in patients with essential thrombocythemia (ET) is based on advanced age and history of thrombotic events. Recently, International Prognostic Score for ET (IPSET) incorporated also leukocytosis in prognostic model. The aim of this study was to establish additional risk factors for OS in ET patients. MethodsAfter the median follow-up of 7yr, in 244 consecutive ET patients, 32 deaths were documented (13.2%). The 5- and 10-yr OS was 95.9% and 79.7%, respectively. Considered additional risk factors at diagnosis of ET were the presence of arterial hypertension, diabetes, hyperlipidemia, and smoking attitude. ResultsThe main cause of death in 75% of patients was cardiovascular (CV) comorbidity. Patients with CV risk factors had increased risk of death (HR=2.33). Cox regression model identified age, leukocytosis, presence of CV risk factors, and previous thrombosis as unfavorable predictors of survival. Based on these parameters, four risk groups were defined, with significantly different survivals (P lt 0.001). Improved prognostic model displayed a better hazard ratio profile compared to the standard risk stratification and IPSET. ConclusionThe addition of CV risk factors allows better prognostic assessment by delineating the intermediate-risk category and improved identification of the high-risk patients.
PB  - Wiley-Blackwell, Hoboken
T2  - European Journal of Haematology
T1  - Predictors of survival and cause of death in patients with essential thrombocythemia
EP  - 466
IS  - 5
SP  - 461
VL  - 95
DO  - 10.1111/ejh.12517
UR  - conv_3622
ER  - 
@article{
author = "Leković, Danijela and Gotić, Mirjana and Sefer, Dijana and Mitrović-Ajtić, Olivera and Čokić, Vladan and Milić, Nataša",
year = "2015",
abstract = "ObjectivesStandard risk stratification for overall survival (OS) in patients with essential thrombocythemia (ET) is based on advanced age and history of thrombotic events. Recently, International Prognostic Score for ET (IPSET) incorporated also leukocytosis in prognostic model. The aim of this study was to establish additional risk factors for OS in ET patients. MethodsAfter the median follow-up of 7yr, in 244 consecutive ET patients, 32 deaths were documented (13.2%). The 5- and 10-yr OS was 95.9% and 79.7%, respectively. Considered additional risk factors at diagnosis of ET were the presence of arterial hypertension, diabetes, hyperlipidemia, and smoking attitude. ResultsThe main cause of death in 75% of patients was cardiovascular (CV) comorbidity. Patients with CV risk factors had increased risk of death (HR=2.33). Cox regression model identified age, leukocytosis, presence of CV risk factors, and previous thrombosis as unfavorable predictors of survival. Based on these parameters, four risk groups were defined, with significantly different survivals (P lt 0.001). Improved prognostic model displayed a better hazard ratio profile compared to the standard risk stratification and IPSET. ConclusionThe addition of CV risk factors allows better prognostic assessment by delineating the intermediate-risk category and improved identification of the high-risk patients.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "European Journal of Haematology",
title = "Predictors of survival and cause of death in patients with essential thrombocythemia",
pages = "466-461",
number = "5",
volume = "95",
doi = "10.1111/ejh.12517",
url = "conv_3622"
}
Leković, D., Gotić, M., Sefer, D., Mitrović-Ajtić, O., Čokić, V.,& Milić, N.. (2015). Predictors of survival and cause of death in patients with essential thrombocythemia. in European Journal of Haematology
Wiley-Blackwell, Hoboken., 95(5), 461-466.
https://doi.org/10.1111/ejh.12517
conv_3622
Leković D, Gotić M, Sefer D, Mitrović-Ajtić O, Čokić V, Milić N. Predictors of survival and cause of death in patients with essential thrombocythemia. in European Journal of Haematology. 2015;95(5):461-466.
doi:10.1111/ejh.12517
conv_3622 .
Leković, Danijela, Gotić, Mirjana, Sefer, Dijana, Mitrović-Ajtić, Olivera, Čokić, Vladan, Milić, Nataša, "Predictors of survival and cause of death in patients with essential thrombocythemia" in European Journal of Haematology, 95, no. 5 (2015):461-466,
https://doi.org/10.1111/ejh.12517 .,
conv_3622 .

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