Predictors of survival and cause of death in patients with essential thrombocythemia
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2015
Authors
Leković, Danijela
Gotić, Mirjana
Sefer, Dijana
Mitrović-Ajtić, Olivera

Čokić, Vladan

Milić, Nataša
Article (Published version)

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ObjectivesStandard risk stratification for overall survival (OS) in patients with essential thrombocythemia (ET) is based on advanced age and history of thrombotic events. Recently, International Prognostic Score for ET (IPSET) incorporated also leukocytosis in prognostic model. The aim of this study was to establish additional risk factors for OS in ET patients. MethodsAfter the median follow-up of 7yr, in 244 consecutive ET patients, 32 deaths were documented (13.2%). The 5- and 10-yr OS was 95.9% and 79.7%, respectively. Considered additional risk factors at diagnosis of ET were the presence of arterial hypertension, diabetes, hyperlipidemia, and smoking attitude. ResultsThe main cause of death in 75% of patients was cardiovascular (CV) comorbidity. Patients with CV risk factors had increased risk of death (HR=2.33). Cox regression model identified age, leukocytosis, presence of CV risk factors, and previous thrombosis as unfavorable predictors of survival. Based on these parameters..., four risk groups were defined, with significantly different survivals (P lt 0.001). Improved prognostic model displayed a better hazard ratio profile compared to the standard risk stratification and IPSET. ConclusionThe addition of CV risk factors allows better prognostic assessment by delineating the intermediate-risk category and improved identification of the high-risk patients.
Keywords:
myeloproliferative neoplasms / essential thrombocythemia / cardiovascular risk factors / prognosis / survivalSource:
European Journal of Haematology, 2015, 95, 5, 461-466Publisher:
- Wiley-Blackwell, Hoboken
Funding / projects:
DOI: 10.1111/ejh.12517
ISSN: 0902-4441
PubMed: 25645731
WoS: 000363328800012
Scopus: 2-s2.0-84944512038
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Institut za medicinska istraživanjaTY - JOUR AU - Leković, Danijela AU - Gotić, Mirjana AU - Sefer, Dijana AU - Mitrović-Ajtić, Olivera AU - Čokić, Vladan AU - Milić, Nataša PY - 2015 UR - http://rimi.imi.bg.ac.rs/handle/123456789/615 AB - ObjectivesStandard risk stratification for overall survival (OS) in patients with essential thrombocythemia (ET) is based on advanced age and history of thrombotic events. Recently, International Prognostic Score for ET (IPSET) incorporated also leukocytosis in prognostic model. The aim of this study was to establish additional risk factors for OS in ET patients. MethodsAfter the median follow-up of 7yr, in 244 consecutive ET patients, 32 deaths were documented (13.2%). The 5- and 10-yr OS was 95.9% and 79.7%, respectively. Considered additional risk factors at diagnosis of ET were the presence of arterial hypertension, diabetes, hyperlipidemia, and smoking attitude. ResultsThe main cause of death in 75% of patients was cardiovascular (CV) comorbidity. Patients with CV risk factors had increased risk of death (HR=2.33). Cox regression model identified age, leukocytosis, presence of CV risk factors, and previous thrombosis as unfavorable predictors of survival. Based on these parameters, four risk groups were defined, with significantly different survivals (P lt 0.001). Improved prognostic model displayed a better hazard ratio profile compared to the standard risk stratification and IPSET. ConclusionThe addition of CV risk factors allows better prognostic assessment by delineating the intermediate-risk category and improved identification of the high-risk patients. PB - Wiley-Blackwell, Hoboken T2 - European Journal of Haematology T1 - Predictors of survival and cause of death in patients with essential thrombocythemia EP - 466 IS - 5 SP - 461 VL - 95 DO - 10.1111/ejh.12517 UR - conv_3622 ER -
@article{ author = "Leković, Danijela and Gotić, Mirjana and Sefer, Dijana and Mitrović-Ajtić, Olivera and Čokić, Vladan and Milić, Nataša", year = "2015", abstract = "ObjectivesStandard risk stratification for overall survival (OS) in patients with essential thrombocythemia (ET) is based on advanced age and history of thrombotic events. Recently, International Prognostic Score for ET (IPSET) incorporated also leukocytosis in prognostic model. The aim of this study was to establish additional risk factors for OS in ET patients. MethodsAfter the median follow-up of 7yr, in 244 consecutive ET patients, 32 deaths were documented (13.2%). The 5- and 10-yr OS was 95.9% and 79.7%, respectively. Considered additional risk factors at diagnosis of ET were the presence of arterial hypertension, diabetes, hyperlipidemia, and smoking attitude. ResultsThe main cause of death in 75% of patients was cardiovascular (CV) comorbidity. Patients with CV risk factors had increased risk of death (HR=2.33). Cox regression model identified age, leukocytosis, presence of CV risk factors, and previous thrombosis as unfavorable predictors of survival. Based on these parameters, four risk groups were defined, with significantly different survivals (P lt 0.001). Improved prognostic model displayed a better hazard ratio profile compared to the standard risk stratification and IPSET. ConclusionThe addition of CV risk factors allows better prognostic assessment by delineating the intermediate-risk category and improved identification of the high-risk patients.", publisher = "Wiley-Blackwell, Hoboken", journal = "European Journal of Haematology", title = "Predictors of survival and cause of death in patients with essential thrombocythemia", pages = "466-461", number = "5", volume = "95", doi = "10.1111/ejh.12517", url = "conv_3622" }
Leković, D., Gotić, M., Sefer, D., Mitrović-Ajtić, O., Čokić, V.,& Milić, N.. (2015). Predictors of survival and cause of death in patients with essential thrombocythemia. in European Journal of Haematology Wiley-Blackwell, Hoboken., 95(5), 461-466. https://doi.org/10.1111/ejh.12517 conv_3622
Leković D, Gotić M, Sefer D, Mitrović-Ajtić O, Čokić V, Milić N. Predictors of survival and cause of death in patients with essential thrombocythemia. in European Journal of Haematology. 2015;95(5):461-466. doi:10.1111/ejh.12517 conv_3622 .
Leković, Danijela, Gotić, Mirjana, Sefer, Dijana, Mitrović-Ajtić, Olivera, Čokić, Vladan, Milić, Nataša, "Predictors of survival and cause of death in patients with essential thrombocythemia" in European Journal of Haematology, 95, no. 5 (2015):461-466, https://doi.org/10.1111/ejh.12517 ., conv_3622 .