Effects of n-3 Fatty Acids Supplementation on Plasma Phospholipids Fatty Acid Composition in Patients with Obstructive Jaundice- a Pilot Study
dc.creator | Popović, Tamara B. | |
dc.creator | Ranić, Marija M. | |
dc.creator | Bulajić, Predrag | |
dc.creator | Milićević, Miroslav | |
dc.creator | Arsić, Aleksandra | |
dc.creator | Vučić, Vesna M. | |
dc.creator | Glibetić, Marija | |
dc.date.accessioned | 2021-04-20T12:17:05Z | |
dc.date.available | 2021-04-20T12:17:05Z | |
dc.date.issued | 2009 | |
dc.identifier.issn | 0912-0009 | |
dc.identifier.uri | http://rimi.imi.bg.ac.rs/handle/123456789/234 | |
dc.description.abstract | Nutritional and immunological status of patients with obstructive jaundice is usually severely altered, with high mortality rates. The n-3 polyunsaturate fatty acids (PUFA), particularly eicosapentaenoic acid (EPA, 20:5 n-3), posess potent immunomodulatory activities. Thus, our aim was to compare the plasma phospholipid fatty acid (FA) composition of these patients with healthy subjects, as well as before and after 7 days preoperative supplementation with high doses of EPA (0.9 g per day) and docosahexaenoic acid (DHA, 22:6 n-3, 0.6 g per day). We found impaired FA status in obstructive jaundice patients, especially EPA, DHA and PUFA, but significantly increased content of total n-3 FA, 22:5 n-3 FA and particularly EPA, which increased more than 3 fold, after 7 days supplementation. In addition, the n6/n3 ratio significantly decreased from 14.24 to 10.24, demonstrating severely improved plasma phospholipid profile in these patients after the intervention. | en |
dc.publisher | Journal Clinical Biochemistry & Nutrition, Kyoto | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/145071/RS// | |
dc.rights | openAccess | |
dc.source | Journal of Clinical Biochemistry & Nutrition | |
dc.subject | obstructive jaundice | en |
dc.subject | fatty acid | en |
dc.subject | n-3 fatty acid supplementation | en |
dc.subject | EPA | en |
dc.subject | DHA | en |
dc.title | Effects of n-3 Fatty Acids Supplementation on Plasma Phospholipids Fatty Acid Composition in Patients with Obstructive Jaundice- a Pilot Study | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 375 | |
dc.citation.issue | 3 | |
dc.citation.other | 45(3): 370-375 | |
dc.citation.rank | M22 | |
dc.citation.spage | 370 | |
dc.citation.volume | 45 | |
dc.identifier.doi | 10.3164/jcbn.09-54 | |
dc.identifier.fulltext | http://rimi.imi.bg.ac.rs/bitstream/id/186/231.pdf | |
dc.identifier.pmid | 19902030 | |
dc.identifier.scopus | 2-s2.0-70549086621 | |
dc.identifier.wos | 000273796300016 | |
dc.type.version | publishedVersion |