Effects of n-3 Fatty Acids Supplementation on Plasma Phospholipids Fatty Acid Composition in Patients with Obstructive Jaundice- a Pilot Study

2009
Authors
Popović, Tamara B.
Ranić, Marija M.

Bulajić, Predrag
Milićević, Miroslav
Arsić, Aleksandra Č.

Vučić, Vesna M.

Glibetić, Marija

Article (Published version)

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Show full item recordAbstract
Nutritional and immunological status of patients with obstructive jaundice is usually severely altered, with high mortality rates. The n-3 polyunsaturate fatty acids (PUFA), particularly eicosapentaenoic acid (EPA, 20:5 n-3), posess potent immunomodulatory activities. Thus, our aim was to compare the plasma phospholipid fatty acid (FA) composition of these patients with healthy subjects, as well as before and after 7 days preoperative supplementation with high doses of EPA (0.9 g per day) and docosahexaenoic acid (DHA, 22:6 n-3, 0.6 g per day). We found impaired FA status in obstructive jaundice patients, especially EPA, DHA and PUFA, but significantly increased content of total n-3 FA, 22:5 n-3 FA and particularly EPA, which increased more than 3 fold, after 7 days supplementation. In addition, the n6/n3 ratio significantly decreased from 14.24 to 10.24, demonstrating severely improved plasma phospholipid profile in these patients after the intervention.
Keywords:
obstructive jaundice / fatty acid / n-3 fatty acid supplementation / EPA / DHASource:
Journal of Clinical Biochemistry & Nutrition, 2009, 45, 3, 370-375Publisher:
- Journal Clinical Biochemistry & Nutrition, Kyoto
Funding / projects:
DOI: 10.3164/jcbn.09-54
ISSN: 0912-0009
PubMed: 19902030
WoS: 000273796300016
Scopus: 2-s2.0-70549086621
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Institut za medicinska istraživanjaTY - JOUR AU - Popović, Tamara B. AU - Ranić, Marija M. AU - Bulajić, Predrag AU - Milićević, Miroslav AU - Arsić, Aleksandra Č. AU - Vučić, Vesna M. AU - Glibetić, Marija PY - 2009 UR - http://rimi.imi.bg.ac.rs/handle/123456789/234 AB - Nutritional and immunological status of patients with obstructive jaundice is usually severely altered, with high mortality rates. The n-3 polyunsaturate fatty acids (PUFA), particularly eicosapentaenoic acid (EPA, 20:5 n-3), posess potent immunomodulatory activities. Thus, our aim was to compare the plasma phospholipid fatty acid (FA) composition of these patients with healthy subjects, as well as before and after 7 days preoperative supplementation with high doses of EPA (0.9 g per day) and docosahexaenoic acid (DHA, 22:6 n-3, 0.6 g per day). We found impaired FA status in obstructive jaundice patients, especially EPA, DHA and PUFA, but significantly increased content of total n-3 FA, 22:5 n-3 FA and particularly EPA, which increased more than 3 fold, after 7 days supplementation. In addition, the n6/n3 ratio significantly decreased from 14.24 to 10.24, demonstrating severely improved plasma phospholipid profile in these patients after the intervention. PB - Journal Clinical Biochemistry & Nutrition, Kyoto T2 - Journal of Clinical Biochemistry & Nutrition T1 - Effects of n-3 Fatty Acids Supplementation on Plasma Phospholipids Fatty Acid Composition in Patients with Obstructive Jaundice- a Pilot Study EP - 375 IS - 3 SP - 370 VL - 45 DO - 10.3164/jcbn.09-54 ER -
@article{ author = "Popović, Tamara B. and Ranić, Marija M. and Bulajić, Predrag and Milićević, Miroslav and Arsić, Aleksandra Č. and Vučić, Vesna M. and Glibetić, Marija", year = "2009", abstract = "Nutritional and immunological status of patients with obstructive jaundice is usually severely altered, with high mortality rates. The n-3 polyunsaturate fatty acids (PUFA), particularly eicosapentaenoic acid (EPA, 20:5 n-3), posess potent immunomodulatory activities. Thus, our aim was to compare the plasma phospholipid fatty acid (FA) composition of these patients with healthy subjects, as well as before and after 7 days preoperative supplementation with high doses of EPA (0.9 g per day) and docosahexaenoic acid (DHA, 22:6 n-3, 0.6 g per day). We found impaired FA status in obstructive jaundice patients, especially EPA, DHA and PUFA, but significantly increased content of total n-3 FA, 22:5 n-3 FA and particularly EPA, which increased more than 3 fold, after 7 days supplementation. In addition, the n6/n3 ratio significantly decreased from 14.24 to 10.24, demonstrating severely improved plasma phospholipid profile in these patients after the intervention.", publisher = "Journal Clinical Biochemistry & Nutrition, Kyoto", journal = "Journal of Clinical Biochemistry & Nutrition", title = "Effects of n-3 Fatty Acids Supplementation on Plasma Phospholipids Fatty Acid Composition in Patients with Obstructive Jaundice- a Pilot Study", pages = "375-370", number = "3", volume = "45", doi = "10.3164/jcbn.09-54" }
Popović, T. B., Ranić, M. M., Bulajić, P., Milićević, M., Arsić, A. Č., Vučić, V. M.,& Glibetić, M.. (2009). Effects of n-3 Fatty Acids Supplementation on Plasma Phospholipids Fatty Acid Composition in Patients with Obstructive Jaundice- a Pilot Study. in Journal of Clinical Biochemistry & Nutrition Journal Clinical Biochemistry & Nutrition, Kyoto., 45(3), 370-375. https://doi.org/10.3164/jcbn.09-54
Popović TB, Ranić MM, Bulajić P, Milićević M, Arsić AČ, Vučić VM, Glibetić M. Effects of n-3 Fatty Acids Supplementation on Plasma Phospholipids Fatty Acid Composition in Patients with Obstructive Jaundice- a Pilot Study. in Journal of Clinical Biochemistry & Nutrition. 2009;45(3):370-375. doi:10.3164/jcbn.09-54 .
Popović, Tamara B., Ranić, Marija M., Bulajić, Predrag, Milićević, Miroslav, Arsić, Aleksandra Č., Vučić, Vesna M., Glibetić, Marija, "Effects of n-3 Fatty Acids Supplementation on Plasma Phospholipids Fatty Acid Composition in Patients with Obstructive Jaundice- a Pilot Study" in Journal of Clinical Biochemistry & Nutrition, 45, no. 3 (2009):370-375, https://doi.org/10.3164/jcbn.09-54 . .