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Effects of n-3 Fatty Acids Supplementation on Plasma Phospholipids Fatty Acid Composition in Patients with Obstructive Jaundice- a Pilot Study

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2009
231.pdf (208.9Kb)
Authors
Popović, Tamara B.
Ranić, Marija M.
Bulajić, Predrag
Milićević, Miroslav
Arsić, Aleksandra Č.
Vučić, Vesna M.
Glibetić, Marija
Article (Published version)
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Abstract
Nutritional and immunological status of patients with obstructive jaundice is usually severely altered, with high mortality rates. The n-3 polyunsaturate fatty acids (PUFA), particularly eicosapentaenoic acid (EPA, 20:5 n-3), posess potent immunomodulatory activities. Thus, our aim was to compare the plasma phospholipid fatty acid (FA) composition of these patients with healthy subjects, as well as before and after 7 days preoperative supplementation with high doses of EPA (0.9 g per day) and docosahexaenoic acid (DHA, 22:6 n-3, 0.6 g per day). We found impaired FA status in obstructive jaundice patients, especially EPA, DHA and PUFA, but significantly increased content of total n-3 FA, 22:5 n-3 FA and particularly EPA, which increased more than 3 fold, after 7 days supplementation. In addition, the n6/n3 ratio significantly decreased from 14.24 to 10.24, demonstrating severely improved plasma phospholipid profile in these patients after the intervention.
Keywords:
obstructive jaundice / fatty acid / n-3 fatty acid supplementation / EPA / DHA
Source:
Journal of Clinical Biochemistry & Nutrition, 2009, 45, 3, 370-375
Publisher:
  • Journal Clinical Biochemistry & Nutrition, Kyoto
Funding / projects:
  • Razvoj novih terapijskih postupaka u prevenciji i lečenju bolesti jetre: Uloga i mehanizam delovanja polinezasićenih masnih kiselina (RS-145071)

DOI: 10.3164/jcbn.09-54

ISSN: 0912-0009

PubMed: 19902030

WoS: 000273796300016

Scopus: 2-s2.0-70549086621
[ Google Scholar ]
19
15
URI
http://rimi.imi.bg.ac.rs/handle/123456789/234
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
Institut za medicinska istraživanja
TY  - JOUR
AU  - Popović, Tamara B.
AU  - Ranić, Marija M.
AU  - Bulajić, Predrag
AU  - Milićević, Miroslav
AU  - Arsić, Aleksandra Č.
AU  - Vučić, Vesna M.
AU  - Glibetić, Marija
PY  - 2009
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/234
AB  - Nutritional and immunological status of patients with obstructive jaundice is usually severely altered, with high mortality rates. The n-3 polyunsaturate fatty acids (PUFA), particularly eicosapentaenoic acid (EPA, 20:5 n-3), posess potent immunomodulatory activities. Thus, our aim was to compare the plasma phospholipid fatty acid (FA) composition of these patients with healthy subjects, as well as before and after 7 days preoperative supplementation with high doses of EPA (0.9 g per day) and docosahexaenoic acid (DHA, 22:6 n-3, 0.6 g per day). We found impaired FA status in obstructive jaundice patients, especially EPA, DHA and PUFA, but significantly increased content of total n-3 FA, 22:5 n-3 FA and particularly EPA, which increased more than 3 fold, after 7 days supplementation. In addition, the n6/n3 ratio significantly decreased from 14.24 to 10.24, demonstrating severely improved plasma phospholipid profile in these patients after the intervention.
PB  - Journal Clinical Biochemistry & Nutrition, Kyoto
T2  - Journal of Clinical Biochemistry & Nutrition
T1  - Effects of n-3 Fatty Acids Supplementation on Plasma Phospholipids Fatty Acid Composition in Patients with Obstructive Jaundice- a Pilot Study
EP  - 375
IS  - 3
SP  - 370
VL  - 45
DO  - 10.3164/jcbn.09-54
ER  - 
@article{
author = "Popović, Tamara B. and Ranić, Marija M. and Bulajić, Predrag and Milićević, Miroslav and Arsić, Aleksandra Č. and Vučić, Vesna M. and Glibetić, Marija",
year = "2009",
abstract = "Nutritional and immunological status of patients with obstructive jaundice is usually severely altered, with high mortality rates. The n-3 polyunsaturate fatty acids (PUFA), particularly eicosapentaenoic acid (EPA, 20:5 n-3), posess potent immunomodulatory activities. Thus, our aim was to compare the plasma phospholipid fatty acid (FA) composition of these patients with healthy subjects, as well as before and after 7 days preoperative supplementation with high doses of EPA (0.9 g per day) and docosahexaenoic acid (DHA, 22:6 n-3, 0.6 g per day). We found impaired FA status in obstructive jaundice patients, especially EPA, DHA and PUFA, but significantly increased content of total n-3 FA, 22:5 n-3 FA and particularly EPA, which increased more than 3 fold, after 7 days supplementation. In addition, the n6/n3 ratio significantly decreased from 14.24 to 10.24, demonstrating severely improved plasma phospholipid profile in these patients after the intervention.",
publisher = "Journal Clinical Biochemistry & Nutrition, Kyoto",
journal = "Journal of Clinical Biochemistry & Nutrition",
title = "Effects of n-3 Fatty Acids Supplementation on Plasma Phospholipids Fatty Acid Composition in Patients with Obstructive Jaundice- a Pilot Study",
pages = "375-370",
number = "3",
volume = "45",
doi = "10.3164/jcbn.09-54"
}
Popović, T. B., Ranić, M. M., Bulajić, P., Milićević, M., Arsić, A. Č., Vučić, V. M.,& Glibetić, M.. (2009). Effects of n-3 Fatty Acids Supplementation on Plasma Phospholipids Fatty Acid Composition in Patients with Obstructive Jaundice- a Pilot Study. in Journal of Clinical Biochemistry & Nutrition
Journal Clinical Biochemistry & Nutrition, Kyoto., 45(3), 370-375.
https://doi.org/10.3164/jcbn.09-54
conv_2243
Popović TB, Ranić MM, Bulajić P, Milićević M, Arsić AČ, Vučić VM, Glibetić M. Effects of n-3 Fatty Acids Supplementation on Plasma Phospholipids Fatty Acid Composition in Patients with Obstructive Jaundice- a Pilot Study. in Journal of Clinical Biochemistry & Nutrition. 2009;45(3):370-375.
doi:10.3164/jcbn.09-54
conv_2243 .
Popović, Tamara B., Ranić, Marija M., Bulajić, Predrag, Milićević, Miroslav, Arsić, Aleksandra Č., Vučić, Vesna M., Glibetić, Marija, "Effects of n-3 Fatty Acids Supplementation on Plasma Phospholipids Fatty Acid Composition in Patients with Obstructive Jaundice- a Pilot Study" in Journal of Clinical Biochemistry & Nutrition, 45, no. 3 (2009):370-375,
https://doi.org/10.3164/jcbn.09-54 .,
conv_2243 .

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