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Inhibition of proinflammatory signaling impairs fibrosis of bone marrow mesenchymal stromal cells in myeloproliferative neoplasms
(Korean Society of Medical Biochemistry and Molecular Biology [Associate Organisation]Springer Nature [Commercial Publisher], 2022)
Although bone marrow-derived mesenchymal stromal cells (BM-MSCs) have been identified as a major cellular source of fibrosis, the exact molecular mechanism and signaling pathways involved have not been identified thus far. ...
Increased oxidative stress in diffuse large B-cell lymphoma
(Wolters Kluwer Health, Inc, 2022)
Background: Oxidative stress is caused by imbalance between excessive production of reactive oxygen species and decreased capabilities of antioxidant system, and it is recognized as a feature in cancerogenesis, as well in ...
Transforming growth factor-beta1 and myeloid-derived suppressor cells: A cancerous partnership
(Wiley, 2022)
Transforming growth factor-beta1 (TGF-beta 1) plays a crucial role in tumor progression. It can inhibit early cancer stages but promotes tumor growth and development at the late stages of tumorigenesis. TGF-beta 1 has a ...
Sex Differences and Cytokine Profiles among Patients Hospitalized for COVID-19 and during Their Recovery: The Predominance of Adhesion Molecules in Females and Oxidative Stress in Males
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)
The severity and mortality of coronavirus disease 2019 (COVID-19) are greater in males than in females, though the infection rate is the same in the two sexes. We investigated sex hormone differences associated with the ...
Macrophages Provide Essential Support for Erythropoiesis, and Extracellular ATP Contributes to a Erythropoiesis-Supportive Microenvironment during Repeated Psychological Stress
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)
Psychological stress is a significant contributor to various chronic diseases and affects multiple physiological processes including erythropoiesis. This study aimed to examine the tissue-specific contributions of macrophages ...
The Metabolic Features of Tumor-Associated Macrophages: Opportunities for Immunotherapy?
(Hindawi, 2021)
Besides transformed cells, the tumors are composed of various cell types that contribute to undesirable tumor progression. Tumor-associated macrophages (TAMs) are the most abundant innate immune cells in the tumor ...
IL6 inhibition of inflammatory S100A8/9 proteins is NF-kappa B mediated in essential thrombocythemia
(Wiley, Hoboken, 2020)
This study has been performed to determine the mechanism of activation of the myeloid related S100A proteins by inflammatory cytokines in myeloproliferative neoplasm (MPN). Besides microarray analysis of MPN-derived CD34(+) ...
Interleukin-17 modulates uPA and MMP2 expression in human periodontal ligament mesenchymal stem cells: Involvement of the ERK1/2 MAPK pathway
(Srpsko biološko društvo, 2022)
Periodontal disease is a chronic infection of periodontal tissue characterized by extracellular matrix (ECM) degradation due to increased expression of plasminogen activators and matrix metalloproteinases (MMPs) and various ...
Lipid and cellular profiles of acetabular and femoral bone marrow adipose tissues are distinct in hip osteoarthritis patients
(American Society for Bone and Mineral Research, 2023)
Bone marrow (BM) adipose tissue (BMAT) has been described as lipotoxic factor with negative impacts on skeletal system regeneration and repair. As BMAT undergoes metabolic and cellular
adaptations with age and disease, ...
Regulation of the mesenchymal stem cell fate by interleukin-17: Implications in osteogenic differentiation
(Baishideng Publishing Group, 2021)
Bone regeneration is a tightly regulated process that ensures proper repair and functionality after injury. The delicate balance between bone formation and resorption is governed by cytokines and signaling molecules released ...