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Prikaz rezultata 11-20 od 465
Effects of novel hydroxyapatite-based 3D biomaterials on proliferation and osteoblastic differentiation of mesenchymal stem cells
(Wiley-Blackwell, Hoboken, 2015)
The aim of this study was to examine the differential capacity of isolated dental pulp stem cells (SHED) cultured onto four different scaffold materials. The differential potential of isolated SHED was examined on the ...
Regional hemodynamics after chronic nitric oxide inhibition in spontaneously hypertensive rats
(Elsevier Science Inc, New York, 2000)
Background: Inhibition of nitric oxide (NO) synthase by L-arginine analogs is associated with elevation of blood pressure in rats. Because endothelium-dependent vasomotion in different vascular beds is not homogenous, the ...
Influence of risk factors on onset of hyperlipidemia in patients with cerebrovascular insult
(International Journal of Genetics & Molecular Biology, 2011)
Cerebrovascular insult (CVI) is one of the leading causes of mortality and morbidity worldwide, with significant influence of lifestyle on its development. The aim of this study was to investigate the different risk factors ...
Glycosylation of IgG B cell receptor (IgG BCR) in multiple myeloma: relationship between sialylation and the signal activity of IgG BCR
(Springer, Dordrecht, 2008)
Little is known about the glycosylation of the isotype switched B cell receptor (BCR) in multiple myeloma, and the way it might affect receptor function. In this work IgG BCRs isolated from the individual lysates of ...
Experimental and systems biology studies of the molecular basis for the radioresistance of prostate carcinoma cells
(Springer, New York, 2008)
Molecular mechanisms for the gamma-ionizing radiation (IR) resistance of human prostate cancer cells, PC-3, are not quite clear. Since the low-LET-IR effects are primarily manifested by the generation of reactive oxygen ...
Evidence for an association of high levels of endogenous Acetyl-Ser-Asp-Lys-Pro, a potent mediator of angiogenesis, with acute myeloid leukemia development
(Taylor & Francis Ltd, Abingdon, 2006)
Evidence from clinical and laboratory studies suggests that angiogenesis is important in the progression of solid tumours and hematologic malignancies. We have shown that the naturally occurring tetrapeptide Acetyl-Ser-Asp-Lys-Pro ...
Effects of Nitric Oxide on Red Blood Cell Development and Phenotype
(Current Topics in Developmental Biology, 2008)
Nitric oxide (NO) is a diffusible free radical generated primarily by NO synthases (NOS), isoenzymes that convert the l-arginine and molecular oxygen to citrulline and NO in cells. Endothelial cells as well as macrophages, ...
Hydroxyurea induces the eNOS-cGMP pathway in endothelial cells
(Amer Soc Hematology, Washington, 2006)
Hydroxyurea is a cell-cycle-specific drug that has been used to treat myeloproliferative diseases and sickle cell anemia. We have recently shown that hydroxyurea, like nitric oxide (NO)-donor compounds, increased cGMP ...
Lower Serum Paraoxonase-1 Activity Is Related to Linoleic and Docosahexanoic Fatty Acids in Type 2 Diabetic Patients
(Elsevier Science Inc, New York, 2012)
Background. Serum paraoxonase-1(PON-1) activity is decreased in clinical conditions associated with low high-density lipoprotein cholesterol (HDL-C), increased lipid peroxidation and low-grade chronic inflammation, as in ...
Hydroxyurea increases eNOS protein levels through inhibition of proteasome activity
(Academic Press Inc Elsevier Science, San Diego, 2007)
Recent reports have identified the proteasome as the primary degradation pathway for inducible, neuronal and endothelial nitric oxide synthase (NOS). We have demonstrated that hydroxyurea increased nitric oxide (NO) ...