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TGF-beta/TGF-beta receptor system and its role in physiological and pathological conditions
(Portland Press Ltd, London, 2011)
The TGF-beta (transforming growth factor-beta) system signals via protein kinase receptors and Smad mediators to regulate a plethora of biological processes, including morphogenesis, embryonic development, adult stem cell ...
The Role of the TGF-beta Coreceptor Endoglin in Cancer
(Hindawi Ltd, London, 2010)
Endoglin (CD105) is an auxiliary membrane receptor of transforming growth factor beta (TGF-beta) that interacts with type I and type II TGF-beta receptors and modulates TGF-beta signaling. Endoglin is overexpressed in the ...
Urokinase Type Plasminogen Activator and the Molecular Mechanisms of its Regulation in Cancer
(Bentham Science Publ Ltd, Sharjah, 2017)
Background: Urokinase type plasminogen activator (uPA) is a 53-kDa serine protease initially synthesized as a catalytically inactive single chain polypeptide. Inactive-uPA is subject to proteolytic cleavage, which results ...
Composition and Potential Health Benefits of Pomegranate: A Review
(Bentham Science Publ Ltd, Sharjah, 2019)
Background: Pomegranate (Punica granatum L.) fruits are widely consumed and used as preventive and therapeutic agents since ancient times. Pomegranate is a rich source of a variety of phytochemicals, which are responsible ...
Transforming Growth Factor-Beta and Urokinase Type Plasminoge Interplay in Cancer
(Bentham Science Publ Ltd, Sharjah, 2018)
Transforming growth factor-beta (TGF-beta) is well recognized as playing a double role in tumor progression. Its antitumor role takes place in the early stages of cancer development, when TGF-beta acts as a repressor of ...
Tetraoxanes as inhibitors of apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii growth and anti-cancer molecules
(Srpsko hemijsko društvo, Beograd, 2015)
New cyclohexylidene 1,2,4,5-tetraoxanes with polar guanidine and urea based groups were synthesized and evaluated for their antimalarial activity against chloroquine resistant and susceptible Plasmodium falciparum strains. ...
Characteristics of human adipose mesenchymal stem cells isolated from healthy and cancer affected people and their interactions with human breast cancer cell line MCF-7 in vitro
(Wiley, Hoboken, 2014)
Adipose tissue is an attractive source of mesenchymal stem/stromal cells (MSCs) with potential applications in reconstructive plastic surgery and regenerative medicine. The aim of this study was to characterise human adipose ...
Metabolic Plasticity of Stem Cells and Macrophages in Cancer
(Frontiers Media Sa, Lausanne, 2017)
In addition to providing essential molecules for the overall function of cells, metabolism plays an important role in cell fate and can be affected by microenvironmental stimuli as well as cellular interactions. As a ...
Mesenchymal stromal cell engagement in cancer cell epithelial to mesenchymal transition
(Wiley, Hoboken, 2018)
Due to coexistence of stromal and epithelial tumor cells, their dynamic interactions have been widely recognized as significant cellular components to the tumor tissue integrity. Initiation and outcome of epithelial to ...