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Mesenchymal stromal cell engagement in cancer cell epithelial to mesenchymal transition

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2018
868.pdf (504.2Kb)
Authors
Trivanović, Drenka
Krstić, Jelena
Jauković, Aleksandra
Bugarski, Diana
Santibanez, Juan
Article (Published version)
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Abstract
Due to coexistence of stromal and epithelial tumor cells, their dynamic interactions have been widely recognized as significant cellular components to the tumor tissue integrity. Initiation and outcome of epithelial to mesenchymal transition (EMT) in tumor cells are dependent on their interaction with adjacent or recruited mesenchymal stromal cells (MSCs). A plethora of mechanisms are involved in MSCs-controlled employment of the developmental processes of EMT that contribute to loss of epithelial cell phenotype and acquisition of stemness, invasiveness and chemoresistance of tumor cells. Interplay of MSCs with tumor cells, including interchange of soluble biomolecules, plasma membrane structures, cytoplasmic content, and organelles, is established through cell-cell contact and/or by means of paracrine signaling. The main focus of this review is to summarize knowledge about involvement of MSCs in cancer cell EMT. Understanding the underlying cellular and molecular mechanism involved in... the interplay between MSCs and cancer EMT is essential for development of effective therapy approaches, which in combination with current treatments may improve the control of tumor progression. Developmental Dynamics 247:359-367, 2018.

Keywords:
stem cells / mesenchymal stromal cells / cancer / epithelial to mesenchymal transition
Source:
Developmental Dynamics, 2018, 247, 3, 359-367
Publisher:
  • Wiley, Hoboken
Funding / projects:
  • Phylogenetic anaysis and molecular evolution of highly variable viruses: coinfections, host-pathogene interactions (RS-175024)
  • Regenerative and modulatory potential of adult stem cells (RS-175062)

DOI: 10.1002/dvdy.24583

ISSN: 1058-8388

PubMed: 28850772

WoS: 000425141200005

Scopus: 2-s2.0-85042075453
[ Google Scholar ]
8
7
URI
http://rimi.imi.bg.ac.rs/handle/123456789/871
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
Institut za medicinska istraživanja
TY  - JOUR
AU  - Trivanović, Drenka
AU  - Krstić, Jelena
AU  - Jauković, Aleksandra
AU  - Bugarski, Diana
AU  - Santibanez, Juan
PY  - 2018
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/871
AB  - Due to coexistence of stromal and epithelial tumor cells, their dynamic interactions have been widely recognized as significant cellular components to the tumor tissue integrity. Initiation and outcome of epithelial to mesenchymal transition (EMT) in tumor cells are dependent on their interaction with adjacent or recruited mesenchymal stromal cells (MSCs). A plethora of mechanisms are involved in MSCs-controlled employment of the developmental processes of EMT that contribute to loss of epithelial cell phenotype and acquisition of stemness, invasiveness and chemoresistance of tumor cells. Interplay of MSCs with tumor cells, including interchange of soluble biomolecules, plasma membrane structures, cytoplasmic content, and organelles, is established through cell-cell contact and/or by means of paracrine signaling. The main focus of this review is to summarize knowledge about involvement of MSCs in cancer cell EMT. Understanding the underlying cellular and molecular mechanism involved in the interplay between MSCs and cancer EMT is essential for development of effective therapy approaches, which in combination with current treatments may improve the control of tumor progression. Developmental Dynamics 247:359-367, 2018.
PB  - Wiley, Hoboken
T2  - Developmental Dynamics
T1  - Mesenchymal stromal cell engagement in cancer cell epithelial to mesenchymal transition
EP  - 367
IS  - 3
SP  - 359
VL  - 247
DO  - 10.1002/dvdy.24583
ER  - 
@article{
author = "Trivanović, Drenka and Krstić, Jelena and Jauković, Aleksandra and Bugarski, Diana and Santibanez, Juan",
year = "2018",
abstract = "Due to coexistence of stromal and epithelial tumor cells, their dynamic interactions have been widely recognized as significant cellular components to the tumor tissue integrity. Initiation and outcome of epithelial to mesenchymal transition (EMT) in tumor cells are dependent on their interaction with adjacent or recruited mesenchymal stromal cells (MSCs). A plethora of mechanisms are involved in MSCs-controlled employment of the developmental processes of EMT that contribute to loss of epithelial cell phenotype and acquisition of stemness, invasiveness and chemoresistance of tumor cells. Interplay of MSCs with tumor cells, including interchange of soluble biomolecules, plasma membrane structures, cytoplasmic content, and organelles, is established through cell-cell contact and/or by means of paracrine signaling. The main focus of this review is to summarize knowledge about involvement of MSCs in cancer cell EMT. Understanding the underlying cellular and molecular mechanism involved in the interplay between MSCs and cancer EMT is essential for development of effective therapy approaches, which in combination with current treatments may improve the control of tumor progression. Developmental Dynamics 247:359-367, 2018.",
publisher = "Wiley, Hoboken",
journal = "Developmental Dynamics",
title = "Mesenchymal stromal cell engagement in cancer cell epithelial to mesenchymal transition",
pages = "367-359",
number = "3",
volume = "247",
doi = "10.1002/dvdy.24583"
}
Trivanović, D., Krstić, J., Jauković, A., Bugarski, D.,& Santibanez, J.. (2018). Mesenchymal stromal cell engagement in cancer cell epithelial to mesenchymal transition. in Developmental Dynamics
Wiley, Hoboken., 247(3), 359-367.
https://doi.org/10.1002/dvdy.24583
conv_4228
Trivanović D, Krstić J, Jauković A, Bugarski D, Santibanez J. Mesenchymal stromal cell engagement in cancer cell epithelial to mesenchymal transition. in Developmental Dynamics. 2018;247(3):359-367.
doi:10.1002/dvdy.24583
conv_4228 .
Trivanović, Drenka, Krstić, Jelena, Jauković, Aleksandra, Bugarski, Diana, Santibanez, Juan, "Mesenchymal stromal cell engagement in cancer cell epithelial to mesenchymal transition" in Developmental Dynamics, 247, no. 3 (2018):359-367,
https://doi.org/10.1002/dvdy.24583 .,
conv_4228 .

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