The TGF-beta (transforming growth factor-beta) system signals via protein kinase receptors and Smad mediators to regulate a plethora of biological processes, including morphogenesis, embryonic development, adult stem cell differentiation, immune regulation, wound healing and inflammation. In addition, alterations of specific components of the TGF-beta signalling pathway may contribute to a broad range of pathologies such as cancer, cardiovascular pathology, fibrosis and congenital diseases. The knowledge about the mechanisms involved in TGF-beta signal transduction has allowed a better understanding of the disease pathogenicity as well as the identification of several molecular targets with great potential in therapeutic interventions.
TY - JOUR
AU - Santibanez, Juan
AU - Quintanilla, Miguel
AU - Bernabeu, Carmelo
PY - 2011
UR - http://rimi.imi.bg.ac.rs/handle/123456789/333
AB - The TGF-beta (transforming growth factor-beta) system signals via protein kinase receptors and Smad mediators to regulate a plethora of biological processes, including morphogenesis, embryonic development, adult stem cell differentiation, immune regulation, wound healing and inflammation. In addition, alterations of specific components of the TGF-beta signalling pathway may contribute to a broad range of pathologies such as cancer, cardiovascular pathology, fibrosis and congenital diseases. The knowledge about the mechanisms involved in TGF-beta signal transduction has allowed a better understanding of the disease pathogenicity as well as the identification of several molecular targets with great potential in therapeutic interventions.
PB - Portland Press Ltd, London
T2 - Clinical Science
T1 - TGF-beta/TGF-beta receptor system and its role in physiological and pathological conditions
EP - 251
IS - 5-6
SP - 233
VL - 121
DO - 10.1042/CS20110086
UR - conv_2582
ER -
@article{
author = "Santibanez, Juan and Quintanilla, Miguel and Bernabeu, Carmelo",
year = "2011",
abstract = "The TGF-beta (transforming growth factor-beta) system signals via protein kinase receptors and Smad mediators to regulate a plethora of biological processes, including morphogenesis, embryonic development, adult stem cell differentiation, immune regulation, wound healing and inflammation. In addition, alterations of specific components of the TGF-beta signalling pathway may contribute to a broad range of pathologies such as cancer, cardiovascular pathology, fibrosis and congenital diseases. The knowledge about the mechanisms involved in TGF-beta signal transduction has allowed a better understanding of the disease pathogenicity as well as the identification of several molecular targets with great potential in therapeutic interventions.",
publisher = "Portland Press Ltd, London",
journal = "Clinical Science",
title = "TGF-beta/TGF-beta receptor system and its role in physiological and pathological conditions",
pages = "251-233",
number = "5-6",
volume = "121",
doi = "10.1042/CS20110086",
url = "conv_2582"
}
Santibanez, J., Quintanilla, M.,& Bernabeu, C.. (2011). TGF-beta/TGF-beta receptor system and its role in physiological and pathological conditions. in Clinical Science
Portland Press Ltd, London., 121(5-6), 233-251.
https://doi.org/10.1042/CS20110086
conv_2582
Santibanez J, Quintanilla M, Bernabeu C. TGF-beta/TGF-beta receptor system and its role in physiological and pathological conditions. in Clinical Science. 2011;121(5-6):233-251.
doi:10.1042/CS20110086
conv_2582 .
Santibanez, Juan, Quintanilla, Miguel, Bernabeu, Carmelo, "TGF-beta/TGF-beta receptor system and its role in physiological and pathological conditions" in Clinical Science, 121, no. 5-6 (2011):233-251,
https://doi.org/10.1042/CS20110086 .,
conv_2582 .
