Plasma phospholipid changes are associated with response to chemotherapy in non-Hodgkin lymphoma patients
Само за регистроване кориснике
2017
Аутори
Cvetković, ZoricaMilošević, Maja
Cvetković, Bora
Masnikosa, Romana
Arsić, Aleksandra
Petrović, Snježana
Vučić, Vesna M.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Limited studies have been performed to associate abnormal phospholipid (PL) profile and disease activity in hematological malignancies, including non-Hodgkin lymphoma (NHL). The aim of his study was to evaluate the levels of plasma PL fractions in NHL patients, in response to chemotherapy. Forty non-treated patients with NHL and 25 healthy individuals were recruited. Blood samples from patients were taken before chemotherapy, after 3 cycles and after the end of the treatment, and PL fractions were resolved by one-dimensional thin-layer chromatography. To assess potential relationship between plasma PL profile and response to therapy, patients were divided according to clinical outcome in 3 groups: complete remission (CR), stable disease (SD) and progression (PG). Despite significant differences between NHL patients and healthy controls, no differences were found at baseline among patients divided according to clinical outcome. During and after chemotherapy important alterations in PL p...rofile were observed. Levels of total PLs and all PL fractions decreased in patients with PG while in patients who responded to therapy (CR, SD) PLs significantly increased. Results of our study suggest that changes of total PLs and PL fractions during the therapy are associated with the effects of therapy and clinical outcome in patients with NHL.
Кључне речи:
Plasma phospholipid profile / Chemotherapy / Non-Hodgkin lymphomaИзвор:
Leukemia Research, 2017, 54, 39-46Издавач:
- Pergamon-Elsevier Science Ltd, Oxford
Финансирање / пројекти:
- Биолошки механизми, нутритивни унос и статус полинезасићених масних киселина и фолата: Унапређење исхране у Србији (RS-41030)
- Ћелијска и молекулска основа неуроинфламације: потенцијала циљна места за транслациону медицину и терапију (RS-41014)
DOI: 10.1016/j.leukres.2017.01.004
ISSN: 0145-2126
PubMed: 28107691
WoS: 000397846100007
Scopus: 2-s2.0-85009505648
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Cvetković, Zorica AU - Milošević, Maja AU - Cvetković, Bora AU - Masnikosa, Romana AU - Arsić, Aleksandra AU - Petrović, Snježana AU - Vučić, Vesna M. PY - 2017 UR - http://rimi.imi.bg.ac.rs/handle/123456789/797 AB - Limited studies have been performed to associate abnormal phospholipid (PL) profile and disease activity in hematological malignancies, including non-Hodgkin lymphoma (NHL). The aim of his study was to evaluate the levels of plasma PL fractions in NHL patients, in response to chemotherapy. Forty non-treated patients with NHL and 25 healthy individuals were recruited. Blood samples from patients were taken before chemotherapy, after 3 cycles and after the end of the treatment, and PL fractions were resolved by one-dimensional thin-layer chromatography. To assess potential relationship between plasma PL profile and response to therapy, patients were divided according to clinical outcome in 3 groups: complete remission (CR), stable disease (SD) and progression (PG). Despite significant differences between NHL patients and healthy controls, no differences were found at baseline among patients divided according to clinical outcome. During and after chemotherapy important alterations in PL profile were observed. Levels of total PLs and all PL fractions decreased in patients with PG while in patients who responded to therapy (CR, SD) PLs significantly increased. Results of our study suggest that changes of total PLs and PL fractions during the therapy are associated with the effects of therapy and clinical outcome in patients with NHL. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Leukemia Research T1 - Plasma phospholipid changes are associated with response to chemotherapy in non-Hodgkin lymphoma patients EP - 46 SP - 39 VL - 54 DO - 10.1016/j.leukres.2017.01.004 ER -
@article{ author = "Cvetković, Zorica and Milošević, Maja and Cvetković, Bora and Masnikosa, Romana and Arsić, Aleksandra and Petrović, Snježana and Vučić, Vesna M.", year = "2017", abstract = "Limited studies have been performed to associate abnormal phospholipid (PL) profile and disease activity in hematological malignancies, including non-Hodgkin lymphoma (NHL). The aim of his study was to evaluate the levels of plasma PL fractions in NHL patients, in response to chemotherapy. Forty non-treated patients with NHL and 25 healthy individuals were recruited. Blood samples from patients were taken before chemotherapy, after 3 cycles and after the end of the treatment, and PL fractions were resolved by one-dimensional thin-layer chromatography. To assess potential relationship between plasma PL profile and response to therapy, patients were divided according to clinical outcome in 3 groups: complete remission (CR), stable disease (SD) and progression (PG). Despite significant differences between NHL patients and healthy controls, no differences were found at baseline among patients divided according to clinical outcome. During and after chemotherapy important alterations in PL profile were observed. Levels of total PLs and all PL fractions decreased in patients with PG while in patients who responded to therapy (CR, SD) PLs significantly increased. Results of our study suggest that changes of total PLs and PL fractions during the therapy are associated with the effects of therapy and clinical outcome in patients with NHL.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Leukemia Research", title = "Plasma phospholipid changes are associated with response to chemotherapy in non-Hodgkin lymphoma patients", pages = "46-39", volume = "54", doi = "10.1016/j.leukres.2017.01.004" }
Cvetković, Z., Milošević, M., Cvetković, B., Masnikosa, R., Arsić, A., Petrović, S.,& Vučić, V. M.. (2017). Plasma phospholipid changes are associated with response to chemotherapy in non-Hodgkin lymphoma patients. in Leukemia Research Pergamon-Elsevier Science Ltd, Oxford., 54, 39-46. https://doi.org/10.1016/j.leukres.2017.01.004
Cvetković Z, Milošević M, Cvetković B, Masnikosa R, Arsić A, Petrović S, Vučić VM. Plasma phospholipid changes are associated with response to chemotherapy in non-Hodgkin lymphoma patients. in Leukemia Research. 2017;54:39-46. doi:10.1016/j.leukres.2017.01.004 .
Cvetković, Zorica, Milošević, Maja, Cvetković, Bora, Masnikosa, Romana, Arsić, Aleksandra, Petrović, Snježana, Vučić, Vesna M., "Plasma phospholipid changes are associated with response to chemotherapy in non-Hodgkin lymphoma patients" in Leukemia Research, 54 (2017):39-46, https://doi.org/10.1016/j.leukres.2017.01.004 . .