Hyperbaric oxygenation protects the kidney against ischemia-reperfusion injury
Нема приказа
Аутори
Ivanov, MilanBrkić, Predrag
Vajić, Una Jovana
Mihailović-Stanojević, Nevena
Milačić, Davorka
Jovović, Đurđica
Karanović, Danijela
Đelić, Marina
Jeremić, Rada
Miloradović, Zoran
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Background: Acute kidney injury (AKI) as a consequence of ischemia is a common clinical event that can lead to unacceptably high morbidity and mortality. Hyperbaric oxygen (HBO2) preconditioning has been shown to prevent ischemia-reperfusion injury (IRI) in different tissues. Objectives: The aim of our study was to compare the effects of HBO2 preconditioning on renal hemodynamics, kidney function and oxidative stress in normotensive and spontaneously hypertensive rats that suffered kidney IRI. Methods: An experiment was performed on Wistar (normotensive) and spontaneously hypertensive rats (SHR). The animals were divided into the following experimental groups: sham-operated rats and rats with or without HBO2 preconditioning 24 hours before post-ischemic AKI induction. Treated rats were placed into experimental HBO2 chambers and exposed to pure oxygen twice a day for two consecutive days (2.026 bar of oxygen) for 60 minutes. AKI was performed the next morning. The right kidney was remov...ed and the renal ischemia was performed by clamping the left renal artery for 45 minutes. Results: In this study, HBO2 preconditioning significantly improved disturbed renal hemodynamics, major markers of kidney function in plasma (creatinine, urea and phosphate) as well as antioxidant enzymes (superoxide dismutase and catalase) activities in erythrocytes after AKI induction. Also, HBO2 preconditioning decreased lipid peroxidation in plasma after ischemic AKI. Positive effects were observed in both strains of rats. Conclusions: Our results suggest that HBO2 treatment improves renal hemodynamic and kidney function and decreases oxidative stress of Wistar and SHR rats with an AKI episode. Furthermore, it also implies that pre-existing hypertension does not affect the beneficial effects of HBO2 preconditioning.
Кључне речи:
acute kidney injury / hyperbaric oxygen therapy / hypertension / oxidative stress / reperfusion injuryИзвор:
Undersea & hyperbaric medicine : journal of the Undersea & Hyperbaric Medical Society, Inc, 2020, 47, 1, 21-30Издавач:
- Undersea & Hyperbaric Medical Soc Inc, Durham
Финансирање / пројекти:
- Испитивање антихипертензивног и ренопротективног потенцијала супстанци природног и синтетског порекла у експерименталним моделима кардиоваскуларних и бубрежних обољења (RS-175096)
- Ћелијска и молекулска основа неуроинфламације: потенцијала циљна места за транслациону медицину и терапију (RS-41014)
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Ivanov, Milan AU - Brkić, Predrag AU - Vajić, Una Jovana AU - Mihailović-Stanojević, Nevena AU - Milačić, Davorka AU - Jovović, Đurđica AU - Karanović, Danijela AU - Đelić, Marina AU - Jeremić, Rada AU - Miloradović, Zoran PY - 2020 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1063 AB - Background: Acute kidney injury (AKI) as a consequence of ischemia is a common clinical event that can lead to unacceptably high morbidity and mortality. Hyperbaric oxygen (HBO2) preconditioning has been shown to prevent ischemia-reperfusion injury (IRI) in different tissues. Objectives: The aim of our study was to compare the effects of HBO2 preconditioning on renal hemodynamics, kidney function and oxidative stress in normotensive and spontaneously hypertensive rats that suffered kidney IRI. Methods: An experiment was performed on Wistar (normotensive) and spontaneously hypertensive rats (SHR). The animals were divided into the following experimental groups: sham-operated rats and rats with or without HBO2 preconditioning 24 hours before post-ischemic AKI induction. Treated rats were placed into experimental HBO2 chambers and exposed to pure oxygen twice a day for two consecutive days (2.026 bar of oxygen) for 60 minutes. AKI was performed the next morning. The right kidney was removed and the renal ischemia was performed by clamping the left renal artery for 45 minutes. Results: In this study, HBO2 preconditioning significantly improved disturbed renal hemodynamics, major markers of kidney function in plasma (creatinine, urea and phosphate) as well as antioxidant enzymes (superoxide dismutase and catalase) activities in erythrocytes after AKI induction. Also, HBO2 preconditioning decreased lipid peroxidation in plasma after ischemic AKI. Positive effects were observed in both strains of rats. Conclusions: Our results suggest that HBO2 treatment improves renal hemodynamic and kidney function and decreases oxidative stress of Wistar and SHR rats with an AKI episode. Furthermore, it also implies that pre-existing hypertension does not affect the beneficial effects of HBO2 preconditioning. PB - Undersea & Hyperbaric Medical Soc Inc, Durham T2 - Undersea & hyperbaric medicine : journal of the Undersea & Hyperbaric Medical Society, Inc T1 - Hyperbaric oxygenation protects the kidney against ischemia-reperfusion injury EP - 30 IS - 1 SP - 21 VL - 47 UR - https://hdl.handle.net/21.15107/rcub_rimi_1063 ER -
@article{ author = "Ivanov, Milan and Brkić, Predrag and Vajić, Una Jovana and Mihailović-Stanojević, Nevena and Milačić, Davorka and Jovović, Đurđica and Karanović, Danijela and Đelić, Marina and Jeremić, Rada and Miloradović, Zoran", year = "2020", abstract = "Background: Acute kidney injury (AKI) as a consequence of ischemia is a common clinical event that can lead to unacceptably high morbidity and mortality. Hyperbaric oxygen (HBO2) preconditioning has been shown to prevent ischemia-reperfusion injury (IRI) in different tissues. Objectives: The aim of our study was to compare the effects of HBO2 preconditioning on renal hemodynamics, kidney function and oxidative stress in normotensive and spontaneously hypertensive rats that suffered kidney IRI. Methods: An experiment was performed on Wistar (normotensive) and spontaneously hypertensive rats (SHR). The animals were divided into the following experimental groups: sham-operated rats and rats with or without HBO2 preconditioning 24 hours before post-ischemic AKI induction. Treated rats were placed into experimental HBO2 chambers and exposed to pure oxygen twice a day for two consecutive days (2.026 bar of oxygen) for 60 minutes. AKI was performed the next morning. The right kidney was removed and the renal ischemia was performed by clamping the left renal artery for 45 minutes. Results: In this study, HBO2 preconditioning significantly improved disturbed renal hemodynamics, major markers of kidney function in plasma (creatinine, urea and phosphate) as well as antioxidant enzymes (superoxide dismutase and catalase) activities in erythrocytes after AKI induction. Also, HBO2 preconditioning decreased lipid peroxidation in plasma after ischemic AKI. Positive effects were observed in both strains of rats. Conclusions: Our results suggest that HBO2 treatment improves renal hemodynamic and kidney function and decreases oxidative stress of Wistar and SHR rats with an AKI episode. Furthermore, it also implies that pre-existing hypertension does not affect the beneficial effects of HBO2 preconditioning.", publisher = "Undersea & Hyperbaric Medical Soc Inc, Durham", journal = "Undersea & hyperbaric medicine : journal of the Undersea & Hyperbaric Medical Society, Inc", title = "Hyperbaric oxygenation protects the kidney against ischemia-reperfusion injury", pages = "30-21", number = "1", volume = "47", url = "https://hdl.handle.net/21.15107/rcub_rimi_1063" }
Ivanov, M., Brkić, P., Vajić, U. J., Mihailović-Stanojević, N., Milačić, D., Jovović, Đ., Karanović, D., Đelić, M., Jeremić, R.,& Miloradović, Z.. (2020). Hyperbaric oxygenation protects the kidney against ischemia-reperfusion injury. in Undersea & hyperbaric medicine : journal of the Undersea & Hyperbaric Medical Society, Inc Undersea & Hyperbaric Medical Soc Inc, Durham., 47(1), 21-30. https://hdl.handle.net/21.15107/rcub_rimi_1063
Ivanov M, Brkić P, Vajić UJ, Mihailović-Stanojević N, Milačić D, Jovović Đ, Karanović D, Đelić M, Jeremić R, Miloradović Z. Hyperbaric oxygenation protects the kidney against ischemia-reperfusion injury. in Undersea & hyperbaric medicine : journal of the Undersea & Hyperbaric Medical Society, Inc. 2020;47(1):21-30. https://hdl.handle.net/21.15107/rcub_rimi_1063 .
Ivanov, Milan, Brkić, Predrag, Vajić, Una Jovana, Mihailović-Stanojević, Nevena, Milačić, Davorka, Jovović, Đurđica, Karanović, Danijela, Đelić, Marina, Jeremić, Rada, Miloradović, Zoran, "Hyperbaric oxygenation protects the kidney against ischemia-reperfusion injury" in Undersea & hyperbaric medicine : journal of the Undersea & Hyperbaric Medical Society, Inc, 47, no. 1 (2020):21-30, https://hdl.handle.net/21.15107/rcub_rimi_1063 .