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Transforming growth factor-beta regulation of urokinase type plasminogen system: Mutual interactions and potential combinatory implications in oncotherapies
(Plasminogen Activator: Genetic Factors, Functions & Clinical Applications, 2014)
The urokinase type plasminogen activator (uPA) system comprises uPA, the uPA cell surface receptor (uPAR), plasminogen-plasmin and the uPA inhibitors PAI-1 and 2. This system is involved in the proteolytic degradation and ...
Novel Patents and Cancer Therapies for Transforming Growth Factor-Beta and Urokinase Type Plasminogen Activator: Potential Use of Their Interplay in Tumorigenesis
(Bentham Science Publ Ltd, Sharjah, 2014)
Transforming growth factor beta (TGF-beta) plays different roles in health and disease. TGF-beta has been assumed as a dual factor in tumor growth, since it can repress epithelial tumor development in early stages, while ...