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Putative Role of Neutrophil Extracellular Trap Formation in Chronic Myeloproliferative Neoplasms
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)
Myeloproliferative neoplasms (MPNs) are hematologic malignancies characterized by gene mutations that promote myeloproliferation and resistance to apoptosis via constitutively active signaling pathways, with Janus kinase ...
Easily Applicable Predictive Score for Differential Diagnosis of Prefibrotic Primary Myelofibrosis from Essential Thrombocythemia
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)
Essential thrombocythemia (ET) and prefibrotic primary myelofibrosis (prePMF) initially have a similar phenotypic presentation with thrombocytosis. The aim of our study was to determine significant clinical-laboratory ...
An updated pharmacological insight into calotropin as a potential therapeutic agent in cancer
(Frontiers Media S.A., 2023)
Calotropin is a pharmacologically active compound isolated from milkweed plants like Calotropis procera, Calotropis gigantea, and Asclepias currasavica that belong to the Asclepiadaceae family. All of these plants are ...
Variability of the HCV core region and host genetic and epigenetic factors can predict the response to pegylated interferon/ribavirin therapy in genotype 1b hepatitis C patients from Serbia
(Serbian Biological Society, 2023)
Variations in the hepatitis C virus (HCV) core sequence have been related to disease progression and response to antiviral therapy. Previously we showed that the methylation status of RASSF1A and p16 genes, and IL28B ...
Region-specific differences of marrow adipogenesis in mesenchymal stromal (stem) cells of human acetabulum and femur: involvement of fatty acid oxidation
(American Society for Bone and Mineral Research, 2023)
Aging and disease-induced adipogenesis in skeletal system has been described as detrimental process for bone tissue metabolism. Dynamic of adipogenic program is controlled by microenvironmental factors and activity of bone ...
The Role of Doxycycline and IL-17 in Regenerative Potential of Periodontal Ligament Stem Cells: Implications in Periodontitis
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)
Periodontitis (PD) is a degenerative, bacteria-induced chronic disease of periodontium causing bone resorption and teeth loss. It includes a strong reaction of immune cells through the secretion of proinflammatory factors ...
Use of high-fat high-fructose diet for a model of metabolic syndrome in Wistar rats: challenges remain
(University of Veterinary and Pharmaceutical Sciences, 2023)
Metabolic syndrome (MetS) is a global public health challenge and one of the main risk factors for cardiovascular diseases. Its pandemic prevalence created a demand for developing a relevant model system for deep insight ...
P1653: Inflammation mediated thrombus formation in lymphomas
(Wolters Kluwer Health, Inc., 2023)
Background: Patients with lymphomas increased the risk of thrombotic complications, especially in diagnosis and during chemotherapy treatment, in the range of 2.9-4.2%.
Aims: Our hypothesis is that inflammation and provoked ...
FooDrugs: a comprehensive food–drug interactions database with text documents and transcriptional data
(Oxford University Press, 2023)
Food–drug interactions (FDIs) occur when a food item alters the pharmacokinetics or pharmacodynamics of a drug. FDIs can be clinically relevant, as they can hamper or enhance the therapeutic effects of a drug and impact ...
The Role of Isoflavones in the Prevention of Breast Cancer and Prostate Cancer
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)
This narrative review summarizes epidemiological studies on breast cancer and prostate cancer with an overview of their global incidence distribution to investigate the relationship between these diseases and diet. The ...