Putative Role of Neutrophil Extracellular Trap Formation in Chronic Myeloproliferative Neoplasms
Authors
Marković, Dragana
Maslovarić, Irina

Kovačić, Marijana

Vignjević-Petrinović, Sanja

Ilić, Vesna

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Myeloproliferative neoplasms (MPNs) are hematologic malignancies characterized by gene mutations that promote myeloproliferation and resistance to apoptosis via constitutively active signaling pathways, with Janus kinase 2-signal transducers and the activators of transcription (JAK-STAT) axis as a core part. Chronic inflammation has been described as a pivot for the development and advancement of MPNs from early stage cancer to pronounced bone marrow fibrosis, but there are still unresolved questions regarding this issue. The MPN neutrophils are characterized by upregulation of JAK target genes, they are in a state of activation and with deregulated apoptotic machinery. Deregulated neutrophil apoptotic cell death supports inflammation and steers them towards secondary necrosis or neutrophil extracellular trap (NET) formation, a trigger of inflammation both ways. NETs in proinflammatory bone marrow microenvironment induce hematopoietic precursor proliferation, which has an impact on hem...atopoietic disorders. In MPNs, neutrophils are primed for NET formation, and even though it seems obvious for NETs to intervene in the disease progression by supporting inflammation, no reliable data are available. We discuss in this review the potential pathophysiological relevance of NET formation in MPNs, with the intention of contributing to a better understanding of how neutrophils and neutrophil clonality can orchestrate the evolution of a pathological microenvironment in MPNs.
Keywords:
neutrophil extracellular traps / neutrophils / myeloproliferative neoplasms / inflammation / cell death / apoptosisSource:
International Journal of Molecular Sciences, 2023, 24, 5, 4497-Funding / projects:
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Institut za medicinska istraživanjaTY - JOUR AU - Marković, Dragana AU - Maslovarić, Irina AU - Kovačić, Marijana AU - Vignjević-Petrinović, Sanja AU - Ilić, Vesna PY - 2023 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1288 AB - Myeloproliferative neoplasms (MPNs) are hematologic malignancies characterized by gene mutations that promote myeloproliferation and resistance to apoptosis via constitutively active signaling pathways, with Janus kinase 2-signal transducers and the activators of transcription (JAK-STAT) axis as a core part. Chronic inflammation has been described as a pivot for the development and advancement of MPNs from early stage cancer to pronounced bone marrow fibrosis, but there are still unresolved questions regarding this issue. The MPN neutrophils are characterized by upregulation of JAK target genes, they are in a state of activation and with deregulated apoptotic machinery. Deregulated neutrophil apoptotic cell death supports inflammation and steers them towards secondary necrosis or neutrophil extracellular trap (NET) formation, a trigger of inflammation both ways. NETs in proinflammatory bone marrow microenvironment induce hematopoietic precursor proliferation, which has an impact on hematopoietic disorders. In MPNs, neutrophils are primed for NET formation, and even though it seems obvious for NETs to intervene in the disease progression by supporting inflammation, no reliable data are available. We discuss in this review the potential pathophysiological relevance of NET formation in MPNs, with the intention of contributing to a better understanding of how neutrophils and neutrophil clonality can orchestrate the evolution of a pathological microenvironment in MPNs. T2 - International Journal of Molecular Sciences T1 - Putative Role of Neutrophil Extracellular Trap Formation in Chronic Myeloproliferative Neoplasms IS - 5 SP - 4497 VL - 24 DO - 10.3390/ijms24054497 ER -
@article{ author = "Marković, Dragana and Maslovarić, Irina and Kovačić, Marijana and Vignjević-Petrinović, Sanja and Ilić, Vesna", year = "2023", abstract = "Myeloproliferative neoplasms (MPNs) are hematologic malignancies characterized by gene mutations that promote myeloproliferation and resistance to apoptosis via constitutively active signaling pathways, with Janus kinase 2-signal transducers and the activators of transcription (JAK-STAT) axis as a core part. Chronic inflammation has been described as a pivot for the development and advancement of MPNs from early stage cancer to pronounced bone marrow fibrosis, but there are still unresolved questions regarding this issue. The MPN neutrophils are characterized by upregulation of JAK target genes, they are in a state of activation and with deregulated apoptotic machinery. Deregulated neutrophil apoptotic cell death supports inflammation and steers them towards secondary necrosis or neutrophil extracellular trap (NET) formation, a trigger of inflammation both ways. NETs in proinflammatory bone marrow microenvironment induce hematopoietic precursor proliferation, which has an impact on hematopoietic disorders. In MPNs, neutrophils are primed for NET formation, and even though it seems obvious for NETs to intervene in the disease progression by supporting inflammation, no reliable data are available. We discuss in this review the potential pathophysiological relevance of NET formation in MPNs, with the intention of contributing to a better understanding of how neutrophils and neutrophil clonality can orchestrate the evolution of a pathological microenvironment in MPNs.", journal = "International Journal of Molecular Sciences", title = "Putative Role of Neutrophil Extracellular Trap Formation in Chronic Myeloproliferative Neoplasms", number = "5", pages = "4497", volume = "24", doi = "10.3390/ijms24054497" }
Marković, D., Maslovarić, I., Kovačić, M., Vignjević-Petrinović, S.,& Ilić, V.. (2023). Putative Role of Neutrophil Extracellular Trap Formation in Chronic Myeloproliferative Neoplasms. in International Journal of Molecular Sciences, 24(5), 4497. https://doi.org/10.3390/ijms24054497
Marković D, Maslovarić I, Kovačić M, Vignjević-Petrinović S, Ilić V. Putative Role of Neutrophil Extracellular Trap Formation in Chronic Myeloproliferative Neoplasms. in International Journal of Molecular Sciences. 2023;24(5):4497. doi:10.3390/ijms24054497 .
Marković, Dragana, Maslovarić, Irina, Kovačić, Marijana, Vignjević-Petrinović, Sanja, Ilić, Vesna, "Putative Role of Neutrophil Extracellular Trap Formation in Chronic Myeloproliferative Neoplasms" in International Journal of Molecular Sciences, 24, no. 5 (2023):4497, https://doi.org/10.3390/ijms24054497 . .