Effects of Adrenergic Receptor Stimulation on Human Hemostasis: A Systematic Review
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2023
Authors
Gatica, SebastianAravena, Diego
Echeverría, Cesar
Santibanez, Juan F.
Riedel, Claudia A.
Simon, Felipe
Book part (Published version)
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Catecholamine stimulation over adrenergic receptors results in a state of hypercoagulability. Chronic stress involves the release and increase in circulation of catecholamines and other stress related hormones. Numerous observational studies in human have related stressful scenarios to several coagulation variables, but controlled stimulation with agonists or antagonists to adrenergic receptors are scarce. This systematic review is aimed at presenting an updated appraisal of the effect of adrenergic receptor modulation on variables related to human hemostasis by systematically reviewing the effect of adrenergic receptor-targeting drugs on scale variables related to hemostasis. By searching 3 databases for articles published between January 1st 2011 and February 16th, 2022 reporting effects on coagulation parameters from stimulation with α- or β-adrenergic receptor targeting drugs in humans regardless of baseline condition, excluding records different from original research and those no...t addressing the main aim of this systematic review. Risk of bias assessed using the Revised Cochrane risk-of-bias tool for randomized trials (RoB 2). Tables describing a pro-thrombotic anti-fibrinolytic state induced after β-adrenergic receptor agonist stimulation and the opposite after α1-, β-adrenergic receptor antagonist stimulation were synthesized from 4 eligible records by comparing hemostasis-related variables to their baseline. Notwithstanding this low number of records, experimental interventions included were sound and mostly unbiased, results were coherent, and outcomes were biologically plausible. In summary, this systematic review provides a critical systematic assessment and an updated elaboration, and its shortcomings highlight the need for further investigation in the field of hematology.
Keywords:
Adrenergic / Coagulation / Hemostasis / Catecholamines / FibrinolysisSource:
Advances in Molecular Pathology, 2023, 49-63Publisher:
- Springer Nature
Funding / projects:
- Fondo Nacional de Desarrollo Científico y Tecnológico FONDECYT [Grant numbers 3220565 (SG), 1201039 (FS), 11170840(CE), 1191300 (CR)]
- Iniciativa Científica Milenio ANID, Chile (FS) - The Millennium Nucleus of Ion Channel-Associated Diseases (MiNICAD)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200015 (University of Belgrade, Institute for Medical Research) (RS-MESTD-inst-2020-200015)
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Institution/Community
Institut za medicinska istraživanjaTY - CHAP AU - Gatica, Sebastian AU - Aravena, Diego AU - Echeverría, Cesar AU - Santibanez, Juan F. AU - Riedel, Claudia A. AU - Simon, Felipe PY - 2023 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1390 AB - Catecholamine stimulation over adrenergic receptors results in a state of hypercoagulability. Chronic stress involves the release and increase in circulation of catecholamines and other stress related hormones. Numerous observational studies in human have related stressful scenarios to several coagulation variables, but controlled stimulation with agonists or antagonists to adrenergic receptors are scarce. This systematic review is aimed at presenting an updated appraisal of the effect of adrenergic receptor modulation on variables related to human hemostasis by systematically reviewing the effect of adrenergic receptor-targeting drugs on scale variables related to hemostasis. By searching 3 databases for articles published between January 1st 2011 and February 16th, 2022 reporting effects on coagulation parameters from stimulation with α- or β-adrenergic receptor targeting drugs in humans regardless of baseline condition, excluding records different from original research and those not addressing the main aim of this systematic review. Risk of bias assessed using the Revised Cochrane risk-of-bias tool for randomized trials (RoB 2). Tables describing a pro-thrombotic anti-fibrinolytic state induced after β-adrenergic receptor agonist stimulation and the opposite after α1-, β-adrenergic receptor antagonist stimulation were synthesized from 4 eligible records by comparing hemostasis-related variables to their baseline. Notwithstanding this low number of records, experimental interventions included were sound and mostly unbiased, results were coherent, and outcomes were biologically plausible. In summary, this systematic review provides a critical systematic assessment and an updated elaboration, and its shortcomings highlight the need for further investigation in the field of hematology. PB - Springer Nature T2 - Advances in Molecular Pathology T2 - Advances in Molecular Pathology T1 - Effects of Adrenergic Receptor Stimulation on Human Hemostasis: A Systematic Review EP - 63 SP - 49 DO - 10.1007/978-3-031-26163-3_3 ER -
@inbook{ author = "Gatica, Sebastian and Aravena, Diego and Echeverría, Cesar and Santibanez, Juan F. and Riedel, Claudia A. and Simon, Felipe", year = "2023", abstract = "Catecholamine stimulation over adrenergic receptors results in a state of hypercoagulability. Chronic stress involves the release and increase in circulation of catecholamines and other stress related hormones. Numerous observational studies in human have related stressful scenarios to several coagulation variables, but controlled stimulation with agonists or antagonists to adrenergic receptors are scarce. This systematic review is aimed at presenting an updated appraisal of the effect of adrenergic receptor modulation on variables related to human hemostasis by systematically reviewing the effect of adrenergic receptor-targeting drugs on scale variables related to hemostasis. By searching 3 databases for articles published between January 1st 2011 and February 16th, 2022 reporting effects on coagulation parameters from stimulation with α- or β-adrenergic receptor targeting drugs in humans regardless of baseline condition, excluding records different from original research and those not addressing the main aim of this systematic review. Risk of bias assessed using the Revised Cochrane risk-of-bias tool for randomized trials (RoB 2). Tables describing a pro-thrombotic anti-fibrinolytic state induced after β-adrenergic receptor agonist stimulation and the opposite after α1-, β-adrenergic receptor antagonist stimulation were synthesized from 4 eligible records by comparing hemostasis-related variables to their baseline. Notwithstanding this low number of records, experimental interventions included were sound and mostly unbiased, results were coherent, and outcomes were biologically plausible. In summary, this systematic review provides a critical systematic assessment and an updated elaboration, and its shortcomings highlight the need for further investigation in the field of hematology.", publisher = "Springer Nature", journal = "Advances in Molecular Pathology, Advances in Molecular Pathology", booktitle = "Effects of Adrenergic Receptor Stimulation on Human Hemostasis: A Systematic Review", pages = "63-49", doi = "10.1007/978-3-031-26163-3_3" }
Gatica, S., Aravena, D., Echeverría, C., Santibanez, J. F., Riedel, C. A.,& Simon, F.. (2023). Effects of Adrenergic Receptor Stimulation on Human Hemostasis: A Systematic Review. in Advances in Molecular Pathology Springer Nature., 49-63. https://doi.org/10.1007/978-3-031-26163-3_3
Gatica S, Aravena D, Echeverría C, Santibanez JF, Riedel CA, Simon F. Effects of Adrenergic Receptor Stimulation on Human Hemostasis: A Systematic Review. in Advances in Molecular Pathology. 2023;:49-63. doi:10.1007/978-3-031-26163-3_3 .
Gatica, Sebastian, Aravena, Diego, Echeverría, Cesar, Santibanez, Juan F., Riedel, Claudia A., Simon, Felipe, "Effects of Adrenergic Receptor Stimulation on Human Hemostasis: A Systematic Review" in Advances in Molecular Pathology (2023):49-63, https://doi.org/10.1007/978-3-031-26163-3_3 . .