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Transforming Growth Factor-Beta and Urokinase Type Plasminoge Interplay in Cancer
(Bentham Science Publ Ltd, Sharjah, 2018)
Transforming growth factor-beta (TGF-beta) is well recognized as playing a double role in tumor progression. Its antitumor role takes place in the early stages of cancer development, when TGF-beta acts as a repressor of ...
Overexpression of the Angiogenic Tetrapeptide AcSDKP in Human Malignant Tumors
(Int Inst Anticancer Research, Athens, 2008)
Background: The natural tetrapeptide acetyl-SerAsp-Lys-Pro (AcSDKP), generated from thymosin beta 4 following its cleavage by prolyl oligopeptidase (POP), is a physiological stimulator of angiogenesis. Because of the ...
Urokinase Type Plasminogen Activator and the Molecular Mechanisms of its Regulation in Cancer
(Bentham Science Publ Ltd, Sharjah, 2017)
Background: Urokinase type plasminogen activator (uPA) is a 53-kDa serine protease initially synthesized as a catalytically inactive single chain polypeptide. Inactive-uPA is subject to proteolytic cleavage, which results ...
Composition and Potential Health Benefits of Pomegranate: A Review
(Bentham Science Publ Ltd, Sharjah, 2019)
Background: Pomegranate (Punica granatum L.) fruits are widely consumed and used as preventive and therapeutic agents since ancient times. Pomegranate is a rich source of a variety of phytochemicals, which are responsible ...
Characteristics of human adipose mesenchymal stem cells isolated from healthy and cancer affected people and their interactions with human breast cancer cell line MCF-7 in vitro
(Wiley, Hoboken, 2014)
Adipose tissue is an attractive source of mesenchymal stem/stromal cells (MSCs) with potential applications in reconstructive plastic surgery and regenerative medicine. The aim of this study was to characterise human adipose ...
Tetraoxanes as inhibitors of apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii growth and anti-cancer molecules
(Srpsko hemijsko društvo, Beograd, 2015)
New cyclohexylidene 1,2,4,5-tetraoxanes with polar guanidine and urea based groups were synthesized and evaluated for their antimalarial activity against chloroquine resistant and susceptible Plasmodium falciparum strains. ...