Background: The natural tetrapeptide acetyl-SerAsp-Lys-Pro (AcSDKP), generated from thymosin beta 4 following its cleavage by prolyl oligopeptidase (POP), is a physiological stimulator of angiogenesis. Because of the critical role of neovascularisation in tumor development, the expression of AcSDKP and the activity of POP were examined in different human solid malignancies. Materials and Methods: The expression of AcSDKP and the activity of POP were evaluated in human blood samples and tissue specimens of thyroid goiter and thyroid papillary carcinoma as well as in commercial cancer tissue microarray. Results: A significantly increased concentration of AcSDKP in intratumoral blood and enhanced tissular activity of POP were detected in cancer patients. The expression of AcSDKP in human breast, colon, head and neck, kidney, lung, skin, ovary and prostate cancer tissues was shown to be greater than that in normal tissues. Conclusion: AcSDKP and POP contribute to the malignant phenotype an...d these molecules are potentiel markers of cancer.
Keywords:
AcSDKP / POP / marker / angiogenesis / thyroid tumor / cancer
Source:
Anticancer Research, 2008, 28, 5A, 2813-2817
Publisher:
Int Inst Anticancer Research, Athens
Funding / projects:
Centre of Excellence MolMed [QJK3-CD-2002-30326]
Institut de Chimie des Substances Naturelles, CNRSCentre National de la Recherche Scientifique (CNRS)
TY - JOUR
AU - Liu, Jian-Miao
AU - Kusinski, Michal
AU - Ilić, Vesna
AU - Bignon, Jerome
AU - Hajem, Neila
AU - Komorowski, Jan
AU - Kuzdak, Krzysztof
AU - Stepien, Henryk
AU - Wdzieczak-Bakala, Joanna
PY - 2008
UR - http://rimi.imi.bg.ac.rs/handle/123456789/204
AB - Background: The natural tetrapeptide acetyl-SerAsp-Lys-Pro (AcSDKP), generated from thymosin beta 4 following its cleavage by prolyl oligopeptidase (POP), is a physiological stimulator of angiogenesis. Because of the critical role of neovascularisation in tumor development, the expression of AcSDKP and the activity of POP were examined in different human solid malignancies. Materials and Methods: The expression of AcSDKP and the activity of POP were evaluated in human blood samples and tissue specimens of thyroid goiter and thyroid papillary carcinoma as well as in commercial cancer tissue microarray. Results: A significantly increased concentration of AcSDKP in intratumoral blood and enhanced tissular activity of POP were detected in cancer patients. The expression of AcSDKP in human breast, colon, head and neck, kidney, lung, skin, ovary and prostate cancer tissues was shown to be greater than that in normal tissues. Conclusion: AcSDKP and POP contribute to the malignant phenotype and these molecules are potentiel markers of cancer.
PB - Int Inst Anticancer Research, Athens
T2 - Anticancer Research
T1 - Overexpression of the Angiogenic Tetrapeptide AcSDKP in Human Malignant Tumors
EP - 2817
IS - 5A
SP - 2813
VL - 28
UR - conv_2034
ER -
@article{
author = "Liu, Jian-Miao and Kusinski, Michal and Ilić, Vesna and Bignon, Jerome and Hajem, Neila and Komorowski, Jan and Kuzdak, Krzysztof and Stepien, Henryk and Wdzieczak-Bakala, Joanna",
year = "2008",
abstract = "Background: The natural tetrapeptide acetyl-SerAsp-Lys-Pro (AcSDKP), generated from thymosin beta 4 following its cleavage by prolyl oligopeptidase (POP), is a physiological stimulator of angiogenesis. Because of the critical role of neovascularisation in tumor development, the expression of AcSDKP and the activity of POP were examined in different human solid malignancies. Materials and Methods: The expression of AcSDKP and the activity of POP were evaluated in human blood samples and tissue specimens of thyroid goiter and thyroid papillary carcinoma as well as in commercial cancer tissue microarray. Results: A significantly increased concentration of AcSDKP in intratumoral blood and enhanced tissular activity of POP were detected in cancer patients. The expression of AcSDKP in human breast, colon, head and neck, kidney, lung, skin, ovary and prostate cancer tissues was shown to be greater than that in normal tissues. Conclusion: AcSDKP and POP contribute to the malignant phenotype and these molecules are potentiel markers of cancer.",
publisher = "Int Inst Anticancer Research, Athens",
journal = "Anticancer Research",
title = "Overexpression of the Angiogenic Tetrapeptide AcSDKP in Human Malignant Tumors",
pages = "2817-2813",
number = "5A",
volume = "28",
url = "conv_2034"
}
Liu, J., Kusinski, M., Ilić, V., Bignon, J., Hajem, N., Komorowski, J., Kuzdak, K., Stepien, H.,& Wdzieczak-Bakala, J.. (2008). Overexpression of the Angiogenic Tetrapeptide AcSDKP in Human Malignant Tumors. in Anticancer Research
Int Inst Anticancer Research, Athens., 28(5A), 2813-2817.
conv_2034
Liu J, Kusinski M, Ilić V, Bignon J, Hajem N, Komorowski J, Kuzdak K, Stepien H, Wdzieczak-Bakala J. Overexpression of the Angiogenic Tetrapeptide AcSDKP in Human Malignant Tumors. in Anticancer Research. 2008;28(5A):2813-2817.
conv_2034 .
Liu, Jian-Miao, Kusinski, Michal, Ilić, Vesna, Bignon, Jerome, Hajem, Neila, Komorowski, Jan, Kuzdak, Krzysztof, Stepien, Henryk, Wdzieczak-Bakala, Joanna, "Overexpression of the Angiogenic Tetrapeptide AcSDKP in Human Malignant Tumors" in Anticancer Research, 28, no. 5A (2008):2813-2817,
conv_2034 .
