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Urokinase Type Plasminogen Activator and the Molecular Mechanisms of its Regulation in Cancer
(Bentham Science Publ Ltd, Sharjah, 2017)
Background: Urokinase type plasminogen activator (uPA) is a 53-kDa serine protease initially synthesized as a catalytically inactive single chain polypeptide. Inactive-uPA is subject to proteolytic cleavage, which results ...
Composition and Potential Health Benefits of Pomegranate: A Review
(Bentham Science Publ Ltd, Sharjah, 2019)
Background: Pomegranate (Punica granatum L.) fruits are widely consumed and used as preventive and therapeutic agents since ancient times. Pomegranate is a rich source of a variety of phytochemicals, which are responsible ...
Overexpression of the Angiogenic Tetrapeptide AcSDKP in Human Malignant Tumors
(Int Inst Anticancer Research, Athens, 2008)
Background: The natural tetrapeptide acetyl-SerAsp-Lys-Pro (AcSDKP), generated from thymosin beta 4 following its cleavage by prolyl oligopeptidase (POP), is a physiological stimulator of angiogenesis. Because of the ...
Transforming Growth Factor-Beta and Urokinase Type Plasminoge Interplay in Cancer
(Bentham Science Publ Ltd, Sharjah, 2018)
Transforming growth factor-beta (TGF-beta) is well recognized as playing a double role in tumor progression. Its antitumor role takes place in the early stages of cancer development, when TGF-beta acts as a repressor of ...
Characteristics of human adipose mesenchymal stem cells isolated from healthy and cancer affected people and their interactions with human breast cancer cell line MCF-7 in vitro
(Wiley, Hoboken, 2014)
Adipose tissue is an attractive source of mesenchymal stem/stromal cells (MSCs) with potential applications in reconstructive plastic surgery and regenerative medicine. The aim of this study was to characterise human adipose ...