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Dietary patterns, caloric restrictions for management of cardiovascular disease and cancer; a brief review
(IMR Press Limited, 2022)
Cardiovascular disease (CVD) and cancers are overall still identified as the two most prevalent non-communicable diseases globally. Their prevention and potential reversal (in particular CVD risk) was seen effective with ...
Overexpression of the Angiogenic Tetrapeptide AcSDKP in Human Malignant Tumors
(Int Inst Anticancer Research, Athens, 2008)
Background: The natural tetrapeptide acetyl-SerAsp-Lys-Pro (AcSDKP), generated from thymosin beta 4 following its cleavage by prolyl oligopeptidase (POP), is a physiological stimulator of angiogenesis. Because of the ...
Interplay between stress and cancer—A focus on inflammation
(Frontiers Media S.A., 2023)
Stress is an integral part of life. While acute responses to stress are generally regarded as beneficial in dealing with immediate threats, chronic exposure to threatening stimuli exerts deleterious effects and can be ...
Targeting Stress Erythropoiesis Pathways in Cancer
(Frontiers Media S.A, 2022)
Cancer-related anemia (CRA) is a common multifactorial disorder that adversely affects the quality of life and overall prognosis in patients with cancer. Safety concerns associated with the most common CRA treatment options, ...
TGF-beta/TGF-beta receptor system and its role in physiological and pathological conditions
(Portland Press Ltd, London, 2011)
The TGF-beta (transforming growth factor-beta) system signals via protein kinase receptors and Smad mediators to regulate a plethora of biological processes, including morphogenesis, embryonic development, adult stem cell ...
The Role of the TGF-beta Coreceptor Endoglin in Cancer
(Hindawi Ltd, London, 2010)
Endoglin (CD105) is an auxiliary membrane receptor of transforming growth factor beta (TGF-beta) that interacts with type I and type II TGF-beta receptors and modulates TGF-beta signaling. Endoglin is overexpressed in the ...
Urokinase Type Plasminogen Activator and the Molecular Mechanisms of its Regulation in Cancer
(Bentham Science Publ Ltd, Sharjah, 2017)
Background: Urokinase type plasminogen activator (uPA) is a 53-kDa serine protease initially synthesized as a catalytically inactive single chain polypeptide. Inactive-uPA is subject to proteolytic cleavage, which results ...
Composition and Potential Health Benefits of Pomegranate: A Review
(Bentham Science Publ Ltd, Sharjah, 2019)
Background: Pomegranate (Punica granatum L.) fruits are widely consumed and used as preventive and therapeutic agents since ancient times. Pomegranate is a rich source of a variety of phytochemicals, which are responsible ...
Transforming Growth Factor-Beta and Urokinase Type Plasminoge Interplay in Cancer
(Bentham Science Publ Ltd, Sharjah, 2018)
Transforming growth factor-beta (TGF-beta) is well recognized as playing a double role in tumor progression. Its antitumor role takes place in the early stages of cancer development, when TGF-beta acts as a repressor of ...
Transforming growth factor-beta1 and myeloid-derived suppressor cells: A cancerous partnership
(Wiley, 2022)
Transforming growth factor-beta1 (TGF-beta 1) plays a crucial role in tumor progression. It can inhibit early cancer stages but promotes tumor growth and development at the late stages of tumorigenesis. TGF-beta 1 has a ...