TY  - JOUR
AU  - Leković, Danijela
AU  - Bogdanović, Andrija
AU  - Sobas, Marta
AU  - Arsenović, Isidora
AU  - Smiljanić, Mihailo
AU  - Ivanović, Jelena
AU  - Bodrožić, Jelena
AU  - Čokić, Vladan
AU  - Milić, Nataša
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1344
AB  - Essential thrombocythemia (ET) and prefibrotic primary myelofibrosis (prePMF) initially have a similar phenotypic presentation with thrombocytosis. The aim of our study was to determine significant clinical-laboratory parameters at presentation to differentiate prePMF from ET as well as to develop and validate a predictive diagnostic prePMF model. This retrospective study included 464 patients divided into ET (289 pts) and prePMF (175 pts) groups. The model was built using data from a development cohort (229 pts; 143 ET, 86 prePMF), which was then tested in an internal validation cohort (235 pts; 146 ET, 89 prePMF). The most important prePMF predictors in the multivariate logistic model were age ≥ 60 years (RR = 2.2), splenomegaly (RR = 13.2), and increased lactat-dehidrogenase (RR = 2.8). Risk scores were assigned according to derived relative risk (RR) for age ≥ 60 years (1 point), splenomegaly (2 points), and increased lactat-dehidrogenase (1 point). Positive predictive value (PPV) for pre-PMF diagnosis with a score of ≥points was 69.8%, while for a score of ≥3 it was 88.2%. Diagnostic performance had similar values in the validation cohort. In MPN patients with thrombocytosis at presentation, the application of the new model enables differentiation of pre-PMF from ET, which is clinically relevant considering that these diseases have different prognoses and treatments.
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Cancers
T2  - Cancers
T1  - Easily Applicable Predictive Score for Differential Diagnosis of Prefibrotic Primary Myelofibrosis from Essential Thrombocythemia
IS  - 16
SP  - 4180
VL  - 15
DO  - 10.3390/cancers15164180
ER  - 

@article{
author = "Leković, Danijela and Bogdanović, Andrija and Sobas, Marta and Arsenović, Isidora and Smiljanić, Mihailo and Ivanović, Jelena and Bodrožić, Jelena and Čokić, Vladan and Milić, Nataša",
year = "2023",
abstract = "Essential thrombocythemia (ET) and prefibrotic primary myelofibrosis (prePMF) initially have a similar phenotypic presentation with thrombocytosis. The aim of our study was to determine significant clinical-laboratory parameters at presentation to differentiate prePMF from ET as well as to develop and validate a predictive diagnostic prePMF model. This retrospective study included 464 patients divided into ET (289 pts) and prePMF (175 pts) groups. The model was built using data from a development cohort (229 pts; 143 ET, 86 prePMF), which was then tested in an internal validation cohort (235 pts; 146 ET, 89 prePMF). The most important prePMF predictors in the multivariate logistic model were age ≥ 60 years (RR = 2.2), splenomegaly (RR = 13.2), and increased lactat-dehidrogenase (RR = 2.8). Risk scores were assigned according to derived relative risk (RR) for age ≥ 60 years (1 point), splenomegaly (2 points), and increased lactat-dehidrogenase (1 point). Positive predictive value (PPV) for pre-PMF diagnosis with a score of ≥points was 69.8%, while for a score of ≥3 it was 88.2%. Diagnostic performance had similar values in the validation cohort. In MPN patients with thrombocytosis at presentation, the application of the new model enables differentiation of pre-PMF from ET, which is clinically relevant considering that these diseases have different prognoses and treatments.",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Cancers, Cancers",
title = "Easily Applicable Predictive Score for Differential Diagnosis of Prefibrotic Primary Myelofibrosis from Essential Thrombocythemia",
number = "16",
pages = "4180",
volume = "15",
doi = "10.3390/cancers15164180"
}

Leković, D., Bogdanović, A., Sobas, M., Arsenović, I., Smiljanić, M., Ivanović, J., Bodrožić, J., Čokić, V.,& Milić, N.. (2023). Easily Applicable Predictive Score for Differential Diagnosis of Prefibrotic Primary Myelofibrosis from Essential Thrombocythemia. in Cancers
Multidisciplinary Digital Publishing Institute (MDPI)., 15(16), 4180.
https://doi.org/10.3390/cancers15164180

Leković D, Bogdanović A, Sobas M, Arsenović I, Smiljanić M, Ivanović J, Bodrožić J, Čokić V, Milić N. Easily Applicable Predictive Score for Differential Diagnosis of Prefibrotic Primary Myelofibrosis from Essential Thrombocythemia. in Cancers. 2023;15(16):4180.
doi:10.3390/cancers15164180 .

Leković, Danijela, Bogdanović, Andrija, Sobas, Marta, Arsenović, Isidora, Smiljanić, Mihailo, Ivanović, Jelena, Bodrožić, Jelena, Čokić, Vladan, Milić, Nataša, "Easily Applicable Predictive Score for Differential Diagnosis of Prefibrotic Primary Myelofibrosis from Essential Thrombocythemia" in Cancers, 15, no. 16 (2023):4180,
https://doi.org/10.3390/cancers15164180 . .