TY  - JOUR
AU  - Čokić, Vladan
AU  - Popovska, Zorana
AU  - Lijeskić, Olivera
AU  - Šabić, Ljiljana
AU  - Đurković-Đaković, Olgica
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1317
AB  - Older people in nursing homes (NH) have been hit particularly hard by the COVID-19 pandemic. We conducted a retrospective study of three outbreaks of COVID-19, occurring during the waves of the initial pre-Alpha, Delta and Omicron SARS-CoV-2 variants, in one NH in suburban Belgrade, Serbia. All staff and 95% residents were vaccinated in February 2021, mostly with BBIBP-CorV, and two thirds were boosted with a third dose in August 2021. COVID-19 was diagnosed by positive PCR and/or antigen test. After the first outbreak, 80 affected individuals were tested for SARS-CoV-2 specific antibodies. The first outbreak involved 64/126 (50.8%) residents and 45/64 (70.3%) staff, the second 22/75 (29.3%) residents and 3/40 (7.5%) staff, and the third involved 36/110 (32.7%) residents and 19/56 (33.9%) staff. Clinical presentation ranged from asymptomatic to severe, with severe cases referred to hospital ICUs. Deaths occurred only in residents, and the case fatality rate was 31.2%, 9.1% and 0%, respectively in outbreaks 1, 2 and 3. Specific IgG antibodies were detected in all 35 residents and 44 of the 45 staff, and higher IgG levels were detected in the residents (417.3±273.5) than in the staff (201.9±192.9, p<0.0001) despite a double difference in age (79.0±7.4 vs. 40.1±11.5 years). Outbreaks 2 and 3 involved four and 23 breakthrough infections, respectively. Older individuals mounted a good immunological response to SARS-CoV-2 infection and vaccination, which prevented significant mortality and severe morbidity in the subsequent outbreaks, despite a significant number of breakthrough infections.
PB  - International Society on Aging and Disease
T2  - Aging and disease
T1  - Three Outbreaks of COVID-19 in a Single Nursing Home over Two Years of the SARS-CoV-2 Pandemic
EP  - 111
IS  - 1
SP  - 99
VL  - 14
DO  - 10.14336/AD.2022.0624
ER  - 

@article{
author = "Čokić, Vladan and Popovska, Zorana and Lijeskić, Olivera and Šabić, Ljiljana and Đurković-Đaković, Olgica",
year = "2023",
abstract = "Older people in nursing homes (NH) have been hit particularly hard by the COVID-19 pandemic. We conducted a retrospective study of three outbreaks of COVID-19, occurring during the waves of the initial pre-Alpha, Delta and Omicron SARS-CoV-2 variants, in one NH in suburban Belgrade, Serbia. All staff and 95% residents were vaccinated in February 2021, mostly with BBIBP-CorV, and two thirds were boosted with a third dose in August 2021. COVID-19 was diagnosed by positive PCR and/or antigen test. After the first outbreak, 80 affected individuals were tested for SARS-CoV-2 specific antibodies. The first outbreak involved 64/126 (50.8%) residents and 45/64 (70.3%) staff, the second 22/75 (29.3%) residents and 3/40 (7.5%) staff, and the third involved 36/110 (32.7%) residents and 19/56 (33.9%) staff. Clinical presentation ranged from asymptomatic to severe, with severe cases referred to hospital ICUs. Deaths occurred only in residents, and the case fatality rate was 31.2%, 9.1% and 0%, respectively in outbreaks 1, 2 and 3. Specific IgG antibodies were detected in all 35 residents and 44 of the 45 staff, and higher IgG levels were detected in the residents (417.3±273.5) than in the staff (201.9±192.9, p<0.0001) despite a double difference in age (79.0±7.4 vs. 40.1±11.5 years). Outbreaks 2 and 3 involved four and 23 breakthrough infections, respectively. Older individuals mounted a good immunological response to SARS-CoV-2 infection and vaccination, which prevented significant mortality and severe morbidity in the subsequent outbreaks, despite a significant number of breakthrough infections.",
publisher = "International Society on Aging and Disease",
journal = "Aging and disease",
title = "Three Outbreaks of COVID-19 in a Single Nursing Home over Two Years of the SARS-CoV-2 Pandemic",
pages = "111-99",
number = "1",
volume = "14",
doi = "10.14336/AD.2022.0624"
}

Čokić, V., Popovska, Z., Lijeskić, O., Šabić, L.,& Đurković-Đaković, O.. (2023). Three Outbreaks of COVID-19 in a Single Nursing Home over Two Years of the SARS-CoV-2 Pandemic. in Aging and disease
International Society on Aging and Disease., 14(1), 99-111.
https://doi.org/10.14336/AD.2022.0624

Čokić V, Popovska Z, Lijeskić O, Šabić L, Đurković-Đaković O. Three Outbreaks of COVID-19 in a Single Nursing Home over Two Years of the SARS-CoV-2 Pandemic. in Aging and disease. 2023;14(1):99-111.
doi:10.14336/AD.2022.0624 .

Čokić, Vladan, Popovska, Zorana, Lijeskić, Olivera, Šabić, Ljiljana, Đurković-Đaković, Olgica, "Three Outbreaks of COVID-19 in a Single Nursing Home over Two Years of the SARS-CoV-2 Pandemic" in Aging and disease, 14, no. 1 (2023):99-111,
https://doi.org/10.14336/AD.2022.0624 . .

TY  - CONF
AU  - Čokić, Vladan
AU  - Popovska, Zorana
AU  - Lijeskić, Olivera
AU  - Šabić, Ljiljana
AU  - Đurković-Đaković, Olgica
PY  - 2022
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1455
AB  - Background: Over the two years of the COVID-19 pandemic, the elderly in nursing
homes (NH) have been hit particularly hard.
Methods: We conducted a retrospective study of 3 episodes of COVID-19 in one NH in
suburban Belgrade, Serbia, at the time of pre-alpha (Nov 2020), delta (Nov 2021) and
omicron (Jan 2022) variants of SARS-CoV-2. All staff and 95% of residents were vaccinated
in the early spring of 2021, with BBIBP-CorV, Gam-COVID-Vac and BNT162b2
vaccines. COVID-19 was diagnosed by positive PCR and/or antigen test. Specific IgG
antibodies against SARS-CoV-2 S glycoprotein RBD were assessed by ELISA.
Results: The 3 episodes involved a total of 188 infections. The first involved 65/126
(51.9%) residents and 44/64 (68.7%) staff, the second 22/75 (29.3%) residents and 3/40
(7.5%) staff, and the third 36/110 (32.7%) residents and 18/56 (32.1%) staff. Clinical presentation
ranged from asymptomatic to severe, with severe cases being referred to
hospital ICUs. Mortality per episode was 19.8%, 2.7% and 0%, respectively, and involved
residents only. After the first episode, all 36 examined residents and 43 of the
44 staff had specific antibodies. Interestingly, higher levels (20.45±13.27) were detected
in the residents than in the staff (9.74±9.52) (p<0.001) despite a double difference
in age (79.6±7.48 vs. 40.8±11.43) (p<0.001). Episodes 2 and 3 involved 4 (1 resident, 3
staff) and 22 (13 residents, 9 staff) breakthrough infections.
Conclusions: Elderly individuals mounted a good immunological response to the
vaccines, which prevented significant mortality in the next episodes, despite a significant
number of omicron-induced breakthrough infections.
PB  - Belgrade: MEDAPP Association
C3  - The First World Conference Fighting COVID-19 Pandemic - Health Challenges, 26-28 March 2022, Belgrade, Serbia -Abstract book
T1  - Three Episodes of COVID-19 in a Nursing Home in Belgrade, Serbia
EP  - 94
SP  - 94
UR  - https://hdl.handle.net/21.15107/rcub_rimi_1455
ER  - 

@conference{
author = "Čokić, Vladan and Popovska, Zorana and Lijeskić, Olivera and Šabić, Ljiljana and Đurković-Đaković, Olgica",
year = "2022",
abstract = "Background: Over the two years of the COVID-19 pandemic, the elderly in nursing
homes (NH) have been hit particularly hard.
Methods: We conducted a retrospective study of 3 episodes of COVID-19 in one NH in
suburban Belgrade, Serbia, at the time of pre-alpha (Nov 2020), delta (Nov 2021) and
omicron (Jan 2022) variants of SARS-CoV-2. All staff and 95% of residents were vaccinated
in the early spring of 2021, with BBIBP-CorV, Gam-COVID-Vac and BNT162b2
vaccines. COVID-19 was diagnosed by positive PCR and/or antigen test. Specific IgG
antibodies against SARS-CoV-2 S glycoprotein RBD were assessed by ELISA.
Results: The 3 episodes involved a total of 188 infections. The first involved 65/126
(51.9%) residents and 44/64 (68.7%) staff, the second 22/75 (29.3%) residents and 3/40
(7.5%) staff, and the third 36/110 (32.7%) residents and 18/56 (32.1%) staff. Clinical presentation
ranged from asymptomatic to severe, with severe cases being referred to
hospital ICUs. Mortality per episode was 19.8%, 2.7% and 0%, respectively, and involved
residents only. After the first episode, all 36 examined residents and 43 of the
44 staff had specific antibodies. Interestingly, higher levels (20.45±13.27) were detected
in the residents than in the staff (9.74±9.52) (p<0.001) despite a double difference
in age (79.6±7.48 vs. 40.8±11.43) (p<0.001). Episodes 2 and 3 involved 4 (1 resident, 3
staff) and 22 (13 residents, 9 staff) breakthrough infections.
Conclusions: Elderly individuals mounted a good immunological response to the
vaccines, which prevented significant mortality in the next episodes, despite a significant
number of omicron-induced breakthrough infections.",
publisher = "Belgrade: MEDAPP Association",
journal = "The First World Conference Fighting COVID-19 Pandemic - Health Challenges, 26-28 March 2022, Belgrade, Serbia -Abstract book",
title = "Three Episodes of COVID-19 in a Nursing Home in Belgrade, Serbia",
pages = "94-94",
url = "https://hdl.handle.net/21.15107/rcub_rimi_1455"
}

Čokić, V., Popovska, Z., Lijeskić, O., Šabić, L.,& Đurković-Đaković, O.. (2022). Three Episodes of COVID-19 in a Nursing Home in Belgrade, Serbia. in The First World Conference Fighting COVID-19 Pandemic - Health Challenges, 26-28 March 2022, Belgrade, Serbia -Abstract book
Belgrade: MEDAPP Association., 94-94.
https://hdl.handle.net/21.15107/rcub_rimi_1455

Čokić V, Popovska Z, Lijeskić O, Šabić L, Đurković-Đaković O. Three Episodes of COVID-19 in a Nursing Home in Belgrade, Serbia. in The First World Conference Fighting COVID-19 Pandemic - Health Challenges, 26-28 March 2022, Belgrade, Serbia -Abstract book. 2022;:94-94.
https://hdl.handle.net/21.15107/rcub_rimi_1455 .

Čokić, Vladan, Popovska, Zorana, Lijeskić, Olivera, Šabić, Ljiljana, Đurković-Đaković, Olgica, "Three Episodes of COVID-19 in a Nursing Home in Belgrade, Serbia" in The First World Conference Fighting COVID-19 Pandemic - Health Challenges, 26-28 March 2022, Belgrade, Serbia -Abstract book (2022):94-94,
https://hdl.handle.net/21.15107/rcub_rimi_1455 .