Three Episodes of COVID-19 in a Nursing Home in Belgrade, Serbia
Апстракт
Background: Over the two years of the COVID-19 pandemic, the elderly in nursing
homes (NH) have been hit particularly hard.
Methods: We conducted a retrospective study of 3 episodes of COVID-19 in one NH in
suburban Belgrade, Serbia, at the time of pre-alpha (Nov 2020), delta (Nov 2021) and
omicron (Jan 2022) variants of SARS-CoV-2. All staff and 95% of residents were vaccinated
in the early spring of 2021, with BBIBP-CorV, Gam-COVID-Vac and BNT162b2
vaccines. COVID-19 was diagnosed by positive PCR and/or antigen test. Specific IgG
antibodies against SARS-CoV-2 S glycoprotein RBD were assessed by ELISA.
Results: The 3 episodes involved a total of 188 infections. The first involved 65/126
(51.9%) residents and 44/64 (68.7%) staff, the second 22/75 (29.3%) residents and 3/40
(7.5%) staff, and the third 36/110 (32.7%) residents and 18/56 (32.1%) staff. Clinical presentation
ranged from asymptomatic to severe, with severe cases being referred to
hospital ICUs. Mortality per epi...sode was 19.8%, 2.7% and 0%, respectively, and involved
residents only. After the first episode, all 36 examined residents and 43 of the
44 staff had specific antibodies. Interestingly, higher levels (20.45±13.27) were detected
in the residents than in the staff (9.74±9.52) (p<0.001) despite a double difference
in age (79.6±7.48 vs. 40.8±11.43) (p<0.001). Episodes 2 and 3 involved 4 (1 resident, 3
staff) and 22 (13 residents, 9 staff) breakthrough infections.
Conclusions: Elderly individuals mounted a good immunological response to the
vaccines, which prevented significant mortality in the next episodes, despite a significant
number of omicron-induced breakthrough infections.
Извор:
The First World Conference Fighting COVID-19 Pandemic - Health Challenges, 26-28 March 2022, Belgrade, Serbia -Abstract book, 2022, 94-94Издавач:
- Belgrade: MEDAPP Association
Колекције
Институција/група
Institut za medicinska istraživanjaTY - CONF AU - Čokić, Vladan AU - Popovska, Zorana AU - Lijeskić, Olivera AU - Šabić, Ljiljana AU - Đurković-Đaković, Olgica PY - 2022 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1455 AB - Background: Over the two years of the COVID-19 pandemic, the elderly in nursing homes (NH) have been hit particularly hard. Methods: We conducted a retrospective study of 3 episodes of COVID-19 in one NH in suburban Belgrade, Serbia, at the time of pre-alpha (Nov 2020), delta (Nov 2021) and omicron (Jan 2022) variants of SARS-CoV-2. All staff and 95% of residents were vaccinated in the early spring of 2021, with BBIBP-CorV, Gam-COVID-Vac and BNT162b2 vaccines. COVID-19 was diagnosed by positive PCR and/or antigen test. Specific IgG antibodies against SARS-CoV-2 S glycoprotein RBD were assessed by ELISA. Results: The 3 episodes involved a total of 188 infections. The first involved 65/126 (51.9%) residents and 44/64 (68.7%) staff, the second 22/75 (29.3%) residents and 3/40 (7.5%) staff, and the third 36/110 (32.7%) residents and 18/56 (32.1%) staff. Clinical presentation ranged from asymptomatic to severe, with severe cases being referred to hospital ICUs. Mortality per episode was 19.8%, 2.7% and 0%, respectively, and involved residents only. After the first episode, all 36 examined residents and 43 of the 44 staff had specific antibodies. Interestingly, higher levels (20.45±13.27) were detected in the residents than in the staff (9.74±9.52) (p<0.001) despite a double difference in age (79.6±7.48 vs. 40.8±11.43) (p<0.001). Episodes 2 and 3 involved 4 (1 resident, 3 staff) and 22 (13 residents, 9 staff) breakthrough infections. Conclusions: Elderly individuals mounted a good immunological response to the vaccines, which prevented significant mortality in the next episodes, despite a significant number of omicron-induced breakthrough infections. PB - Belgrade: MEDAPP Association C3 - The First World Conference Fighting COVID-19 Pandemic - Health Challenges, 26-28 March 2022, Belgrade, Serbia -Abstract book T1 - Three Episodes of COVID-19 in a Nursing Home in Belgrade, Serbia EP - 94 SP - 94 UR - https://hdl.handle.net/21.15107/rcub_rimi_1455 ER -
@conference{ author = "Čokić, Vladan and Popovska, Zorana and Lijeskić, Olivera and Šabić, Ljiljana and Đurković-Đaković, Olgica", year = "2022", abstract = "Background: Over the two years of the COVID-19 pandemic, the elderly in nursing homes (NH) have been hit particularly hard. Methods: We conducted a retrospective study of 3 episodes of COVID-19 in one NH in suburban Belgrade, Serbia, at the time of pre-alpha (Nov 2020), delta (Nov 2021) and omicron (Jan 2022) variants of SARS-CoV-2. All staff and 95% of residents were vaccinated in the early spring of 2021, with BBIBP-CorV, Gam-COVID-Vac and BNT162b2 vaccines. COVID-19 was diagnosed by positive PCR and/or antigen test. Specific IgG antibodies against SARS-CoV-2 S glycoprotein RBD were assessed by ELISA. Results: The 3 episodes involved a total of 188 infections. The first involved 65/126 (51.9%) residents and 44/64 (68.7%) staff, the second 22/75 (29.3%) residents and 3/40 (7.5%) staff, and the third 36/110 (32.7%) residents and 18/56 (32.1%) staff. Clinical presentation ranged from asymptomatic to severe, with severe cases being referred to hospital ICUs. Mortality per episode was 19.8%, 2.7% and 0%, respectively, and involved residents only. After the first episode, all 36 examined residents and 43 of the 44 staff had specific antibodies. Interestingly, higher levels (20.45±13.27) were detected in the residents than in the staff (9.74±9.52) (p<0.001) despite a double difference in age (79.6±7.48 vs. 40.8±11.43) (p<0.001). Episodes 2 and 3 involved 4 (1 resident, 3 staff) and 22 (13 residents, 9 staff) breakthrough infections. Conclusions: Elderly individuals mounted a good immunological response to the vaccines, which prevented significant mortality in the next episodes, despite a significant number of omicron-induced breakthrough infections.", publisher = "Belgrade: MEDAPP Association", journal = "The First World Conference Fighting COVID-19 Pandemic - Health Challenges, 26-28 March 2022, Belgrade, Serbia -Abstract book", title = "Three Episodes of COVID-19 in a Nursing Home in Belgrade, Serbia", pages = "94-94", url = "https://hdl.handle.net/21.15107/rcub_rimi_1455" }
Čokić, V., Popovska, Z., Lijeskić, O., Šabić, L.,& Đurković-Đaković, O.. (2022). Three Episodes of COVID-19 in a Nursing Home in Belgrade, Serbia. in The First World Conference Fighting COVID-19 Pandemic - Health Challenges, 26-28 March 2022, Belgrade, Serbia -Abstract book Belgrade: MEDAPP Association., 94-94. https://hdl.handle.net/21.15107/rcub_rimi_1455
Čokić V, Popovska Z, Lijeskić O, Šabić L, Đurković-Đaković O. Three Episodes of COVID-19 in a Nursing Home in Belgrade, Serbia. in The First World Conference Fighting COVID-19 Pandemic - Health Challenges, 26-28 March 2022, Belgrade, Serbia -Abstract book. 2022;:94-94. https://hdl.handle.net/21.15107/rcub_rimi_1455 .
Čokić, Vladan, Popovska, Zorana, Lijeskić, Olivera, Šabić, Ljiljana, Đurković-Đaković, Olgica, "Three Episodes of COVID-19 in a Nursing Home in Belgrade, Serbia" in The First World Conference Fighting COVID-19 Pandemic - Health Challenges, 26-28 March 2022, Belgrade, Serbia -Abstract book (2022):94-94, https://hdl.handle.net/21.15107/rcub_rimi_1455 .