TY  - JOUR
AU  - Trimigno, Alessia
AU  - Khakimov, Bekzod
AU  - Savorani, Francesco
AU  - Tenori, Leonardo
AU  - Hendrixson, Vaiva
AU  - Civilis, Alminas
AU  - Glibetić, Marija
AU  - Gurinović, Mirjana
AU  - Pentikainen, Saara
AU  - Sallinen, Janne
AU  - Diaz, Sara Garduno
AU  - Pasqui, Francesca
AU  - Khokhar, Santosh
AU  - Luchinat, Claudio
AU  - Bordoni, Alessandra
AU  - Capozzi, Francesco
AU  - Engelsen, Soren Balling
PY  - 2019
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/957
AB  - Scope According to Eurostat 2016, approximately 119 million European citizens live at-risk-of-poverty (ROP). This subpopulation is highly diverse by ethnicity, age, and culture in the different EU states, but they all have in common a low income that could represent an increased risk of nutrient deficiencies due to poor nutritional habits. This study aims to investigate the human urine metabolome in the search of common biomarkers representing dietary deficiencies amongst European populations at ROP. Methods and results 2732 urine samples were collected from 1391 subjects across five different European countries, including the United Kingdom, Finland, Italy, Lithuania, and Serbia, and analyzed using H-1-NMR spectroscopy. The resulting urine metabolome data were explored according to study design factors including economic status, country, and gender. Conclusion Partitioning of the effects derived from the study design factors using ANOVA-simultaneous component analysis (ASCA) revealed that country and gender effects were responsible for most of the systematic variation. The effect of economic status was, as expected, much weaker than country and gender, but more pronounced in Lithuania than in other countries. Citrate and hippurate were among the most powerful ROP biomarkers. The possible relationship between these markers and nutritional deficiencies amongst the ROP population is discussed.
PB  - Wiley, Hoboken
T2  - Molecular Nutrition & Food Research
T1  - Investigation of Variations in the Human Urine Metabolome amongst European Populations: An Exploratory Search for Biomarkers of People at Risk-of-Poverty
IS  - 1
VL  - 63
DO  - 10.1002/mnfr.201800216
ER  - 

@article{
author = "Trimigno, Alessia and Khakimov, Bekzod and Savorani, Francesco and Tenori, Leonardo and Hendrixson, Vaiva and Civilis, Alminas and Glibetić, Marija and Gurinović, Mirjana and Pentikainen, Saara and Sallinen, Janne and Diaz, Sara Garduno and Pasqui, Francesca and Khokhar, Santosh and Luchinat, Claudio and Bordoni, Alessandra and Capozzi, Francesco and Engelsen, Soren Balling",
year = "2019",
abstract = "Scope According to Eurostat 2016, approximately 119 million European citizens live at-risk-of-poverty (ROP). This subpopulation is highly diverse by ethnicity, age, and culture in the different EU states, but they all have in common a low income that could represent an increased risk of nutrient deficiencies due to poor nutritional habits. This study aims to investigate the human urine metabolome in the search of common biomarkers representing dietary deficiencies amongst European populations at ROP. Methods and results 2732 urine samples were collected from 1391 subjects across five different European countries, including the United Kingdom, Finland, Italy, Lithuania, and Serbia, and analyzed using H-1-NMR spectroscopy. The resulting urine metabolome data were explored according to study design factors including economic status, country, and gender. Conclusion Partitioning of the effects derived from the study design factors using ANOVA-simultaneous component analysis (ASCA) revealed that country and gender effects were responsible for most of the systematic variation. The effect of economic status was, as expected, much weaker than country and gender, but more pronounced in Lithuania than in other countries. Citrate and hippurate were among the most powerful ROP biomarkers. The possible relationship between these markers and nutritional deficiencies amongst the ROP population is discussed.",
publisher = "Wiley, Hoboken",
journal = "Molecular Nutrition & Food Research",
title = "Investigation of Variations in the Human Urine Metabolome amongst European Populations: An Exploratory Search for Biomarkers of People at Risk-of-Poverty",
number = "1",
volume = "63",
doi = "10.1002/mnfr.201800216"
}

Trimigno, A., Khakimov, B., Savorani, F., Tenori, L., Hendrixson, V., Civilis, A., Glibetić, M., Gurinović, M., Pentikainen, S., Sallinen, J., Diaz, S. G., Pasqui, F., Khokhar, S., Luchinat, C., Bordoni, A., Capozzi, F.,& Engelsen, S. B.. (2019). Investigation of Variations in the Human Urine Metabolome amongst European Populations: An Exploratory Search for Biomarkers of People at Risk-of-Poverty. in Molecular Nutrition & Food Research
Wiley, Hoboken., 63(1).
https://doi.org/10.1002/mnfr.201800216

Trimigno A, Khakimov B, Savorani F, Tenori L, Hendrixson V, Civilis A, Glibetić M, Gurinović M, Pentikainen S, Sallinen J, Diaz SG, Pasqui F, Khokhar S, Luchinat C, Bordoni A, Capozzi F, Engelsen SB. Investigation of Variations in the Human Urine Metabolome amongst European Populations: An Exploratory Search for Biomarkers of People at Risk-of-Poverty. in Molecular Nutrition & Food Research. 2019;63(1).
doi:10.1002/mnfr.201800216 .

Trimigno, Alessia, Khakimov, Bekzod, Savorani, Francesco, Tenori, Leonardo, Hendrixson, Vaiva, Civilis, Alminas, Glibetić, Marija, Gurinović, Mirjana, Pentikainen, Saara, Sallinen, Janne, Diaz, Sara Garduno, Pasqui, Francesca, Khokhar, Santosh, Luchinat, Claudio, Bordoni, Alessandra, Capozzi, Francesco, Engelsen, Soren Balling, "Investigation of Variations in the Human Urine Metabolome amongst European Populations: An Exploratory Search for Biomarkers of People at Risk-of-Poverty" in Molecular Nutrition & Food Research, 63, no. 1 (2019),
https://doi.org/10.1002/mnfr.201800216 . .

TY  - JOUR
AU  - Nikolić, Marina
AU  - Glibetić, Marija
AU  - Gurinović, Mirjana
AU  - Milešević, Jelena
AU  - Khokhar, Santosh
AU  - Chillo, Stefania
AU  - Abaravicius, Jonas Algis
AU  - Bordoni, Alessandra
AU  - Capozzi, Francesco
PY  - 2014
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/588
AB  - The aim of the CHANCE project is to develop novel and affordable nutritious foods to optimize the diet and reduce the risk of diet-related diseases among groups at risk of poverty (ROP). This paper describes the methodology used in the two initial steps to accomplish the project's objective as follows: 1. a literature review of existing data and 2. an identification of ROP groups with which to design and perform the CHANCE nutritional survey, which will supply new data that is useful for formulating the new CHANCE food. Based on the literature review, a low intake of fruit and vegetables, whole grain products, fish, energy, fiber, vitamins B1, B2, B3, B6, B12 and C, folate, calcium, magnesium, iron, potassium and zinc and a high intake of starchy foods, processed meat and sodium were apparent. However, the available data appeared fragmented because of the different methodologies used in the studies. A more global vision of the main nutritional problems that are present among low-income people in Europe is needed, and the first step to achieve this goal is the use of common criteria to define the risk of poverty. The scoring system described here represents novel criteria for defining at-risk-of-poverty groups not only in the CHANCE-participating countries but also all over Europe.
PB  - MDPI, Basel
T2  - Nutrients
T1  - Identifying Critical Nutrient Intake in Groups at Risk of Poverty in Europe: The CHANCE Project Approach
EP  - 1393
IS  - 4
SP  - 1374
VL  - 6
DO  - 10.3390/nu6041374
ER  - 

@article{
author = "Nikolić, Marina and Glibetić, Marija and Gurinović, Mirjana and Milešević, Jelena and Khokhar, Santosh and Chillo, Stefania and Abaravicius, Jonas Algis and Bordoni, Alessandra and Capozzi, Francesco",
year = "2014",
abstract = "The aim of the CHANCE project is to develop novel and affordable nutritious foods to optimize the diet and reduce the risk of diet-related diseases among groups at risk of poverty (ROP). This paper describes the methodology used in the two initial steps to accomplish the project's objective as follows: 1. a literature review of existing data and 2. an identification of ROP groups with which to design and perform the CHANCE nutritional survey, which will supply new data that is useful for formulating the new CHANCE food. Based on the literature review, a low intake of fruit and vegetables, whole grain products, fish, energy, fiber, vitamins B1, B2, B3, B6, B12 and C, folate, calcium, magnesium, iron, potassium and zinc and a high intake of starchy foods, processed meat and sodium were apparent. However, the available data appeared fragmented because of the different methodologies used in the studies. A more global vision of the main nutritional problems that are present among low-income people in Europe is needed, and the first step to achieve this goal is the use of common criteria to define the risk of poverty. The scoring system described here represents novel criteria for defining at-risk-of-poverty groups not only in the CHANCE-participating countries but also all over Europe.",
publisher = "MDPI, Basel",
journal = "Nutrients",
title = "Identifying Critical Nutrient Intake in Groups at Risk of Poverty in Europe: The CHANCE Project Approach",
pages = "1393-1374",
number = "4",
volume = "6",
doi = "10.3390/nu6041374"
}

Nikolić, M., Glibetić, M., Gurinović, M., Milešević, J., Khokhar, S., Chillo, S., Abaravicius, J. A., Bordoni, A.,& Capozzi, F.. (2014). Identifying Critical Nutrient Intake in Groups at Risk of Poverty in Europe: The CHANCE Project Approach. in Nutrients
MDPI, Basel., 6(4), 1374-1393.
https://doi.org/10.3390/nu6041374

Nikolić M, Glibetić M, Gurinović M, Milešević J, Khokhar S, Chillo S, Abaravicius JA, Bordoni A, Capozzi F. Identifying Critical Nutrient Intake in Groups at Risk of Poverty in Europe: The CHANCE Project Approach. in Nutrients. 2014;6(4):1374-1393.
doi:10.3390/nu6041374 .

Nikolić, Marina, Glibetić, Marija, Gurinović, Mirjana, Milešević, Jelena, Khokhar, Santosh, Chillo, Stefania, Abaravicius, Jonas Algis, Bordoni, Alessandra, Capozzi, Francesco, "Identifying Critical Nutrient Intake in Groups at Risk of Poverty in Europe: The CHANCE Project Approach" in Nutrients, 6, no. 4 (2014):1374-1393,
https://doi.org/10.3390/nu6041374 . .