TY  - JOUR
AU  - Trimigno, Alessia
AU  - Khakimov, Bekzod
AU  - Savorani, Francesco
AU  - Tenori, Leonardo
AU  - Hendrixson, Vaiva
AU  - Civilis, Alminas
AU  - Glibetić, Marija
AU  - Gurinović, Mirjana
AU  - Pentikainen, Saara
AU  - Sallinen, Janne
AU  - Diaz, Sara Garduno
AU  - Pasqui, Francesca
AU  - Khokhar, Santosh
AU  - Luchinat, Claudio
AU  - Bordoni, Alessandra
AU  - Capozzi, Francesco
AU  - Engelsen, Soren Balling
PY  - 2019
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/957
AB  - Scope According to Eurostat 2016, approximately 119 million European citizens live at-risk-of-poverty (ROP). This subpopulation is highly diverse by ethnicity, age, and culture in the different EU states, but they all have in common a low income that could represent an increased risk of nutrient deficiencies due to poor nutritional habits. This study aims to investigate the human urine metabolome in the search of common biomarkers representing dietary deficiencies amongst European populations at ROP. Methods and results 2732 urine samples were collected from 1391 subjects across five different European countries, including the United Kingdom, Finland, Italy, Lithuania, and Serbia, and analyzed using H-1-NMR spectroscopy. The resulting urine metabolome data were explored according to study design factors including economic status, country, and gender. Conclusion Partitioning of the effects derived from the study design factors using ANOVA-simultaneous component analysis (ASCA) revealed that country and gender effects were responsible for most of the systematic variation. The effect of economic status was, as expected, much weaker than country and gender, but more pronounced in Lithuania than in other countries. Citrate and hippurate were among the most powerful ROP biomarkers. The possible relationship between these markers and nutritional deficiencies amongst the ROP population is discussed.
PB  - Wiley, Hoboken
T2  - Molecular Nutrition & Food Research
T1  - Investigation of Variations in the Human Urine Metabolome amongst European Populations: An Exploratory Search for Biomarkers of People at Risk-of-Poverty
IS  - 1
VL  - 63
DO  - 10.1002/mnfr.201800216
ER  - 

@article{
author = "Trimigno, Alessia and Khakimov, Bekzod and Savorani, Francesco and Tenori, Leonardo and Hendrixson, Vaiva and Civilis, Alminas and Glibetić, Marija and Gurinović, Mirjana and Pentikainen, Saara and Sallinen, Janne and Diaz, Sara Garduno and Pasqui, Francesca and Khokhar, Santosh and Luchinat, Claudio and Bordoni, Alessandra and Capozzi, Francesco and Engelsen, Soren Balling",
year = "2019",
abstract = "Scope According to Eurostat 2016, approximately 119 million European citizens live at-risk-of-poverty (ROP). This subpopulation is highly diverse by ethnicity, age, and culture in the different EU states, but they all have in common a low income that could represent an increased risk of nutrient deficiencies due to poor nutritional habits. This study aims to investigate the human urine metabolome in the search of common biomarkers representing dietary deficiencies amongst European populations at ROP. Methods and results 2732 urine samples were collected from 1391 subjects across five different European countries, including the United Kingdom, Finland, Italy, Lithuania, and Serbia, and analyzed using H-1-NMR spectroscopy. The resulting urine metabolome data were explored according to study design factors including economic status, country, and gender. Conclusion Partitioning of the effects derived from the study design factors using ANOVA-simultaneous component analysis (ASCA) revealed that country and gender effects were responsible for most of the systematic variation. The effect of economic status was, as expected, much weaker than country and gender, but more pronounced in Lithuania than in other countries. Citrate and hippurate were among the most powerful ROP biomarkers. The possible relationship between these markers and nutritional deficiencies amongst the ROP population is discussed.",
publisher = "Wiley, Hoboken",
journal = "Molecular Nutrition & Food Research",
title = "Investigation of Variations in the Human Urine Metabolome amongst European Populations: An Exploratory Search for Biomarkers of People at Risk-of-Poverty",
number = "1",
volume = "63",
doi = "10.1002/mnfr.201800216"
}

Trimigno, A., Khakimov, B., Savorani, F., Tenori, L., Hendrixson, V., Civilis, A., Glibetić, M., Gurinović, M., Pentikainen, S., Sallinen, J., Diaz, S. G., Pasqui, F., Khokhar, S., Luchinat, C., Bordoni, A., Capozzi, F.,& Engelsen, S. B.. (2019). Investigation of Variations in the Human Urine Metabolome amongst European Populations: An Exploratory Search for Biomarkers of People at Risk-of-Poverty. in Molecular Nutrition & Food Research
Wiley, Hoboken., 63(1).
https://doi.org/10.1002/mnfr.201800216

Trimigno A, Khakimov B, Savorani F, Tenori L, Hendrixson V, Civilis A, Glibetić M, Gurinović M, Pentikainen S, Sallinen J, Diaz SG, Pasqui F, Khokhar S, Luchinat C, Bordoni A, Capozzi F, Engelsen SB. Investigation of Variations in the Human Urine Metabolome amongst European Populations: An Exploratory Search for Biomarkers of People at Risk-of-Poverty. in Molecular Nutrition & Food Research. 2019;63(1).
doi:10.1002/mnfr.201800216 .

Trimigno, Alessia, Khakimov, Bekzod, Savorani, Francesco, Tenori, Leonardo, Hendrixson, Vaiva, Civilis, Alminas, Glibetić, Marija, Gurinović, Mirjana, Pentikainen, Saara, Sallinen, Janne, Diaz, Sara Garduno, Pasqui, Francesca, Khokhar, Santosh, Luchinat, Claudio, Bordoni, Alessandra, Capozzi, Francesco, Engelsen, Soren Balling, "Investigation of Variations in the Human Urine Metabolome amongst European Populations: An Exploratory Search for Biomarkers of People at Risk-of-Poverty" in Molecular Nutrition & Food Research, 63, no. 1 (2019),
https://doi.org/10.1002/mnfr.201800216 . .